Changes in version 1.4.5 (2021-04-15) o SVA batch effect correction improved o MAD outliers detection fixed o KnowSeq report updated to include the changes of SVA and MAD modifications o Cross-Validation DEGs Extraction implemented Further versions o Incorporation of RUV to batch effect methods Changes in version 1.1.15 (2019-11-11) o Novel Biological Based Feature Selection method named as Disease Association Feature Selection (DA-FS) added Changes in version 0.99.55 (2019-10-09) o Several minor bug fixes and enhancements and xgrid/ygrid added to classification plots Changes in version 0.99.51 (2019-08-19) o New method web platform added (targetValidation) to retrieve the diseases in the DEGsToDiseases function Changes in version 0.99.42 o dataPlots genesBoxplot mode improvements Changes in version 0.99.31 (2019-07-17) o Best tunning parameters for SVM functions Changes in version 0.99.30 (2019-06-05) o Initial release with Bioconductor o Alignment functions only works on Unix system (For now) o The rest of the pipeline is completely functional for all the OS including windows and MAC_OS