{"pathway":"GO_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM","pval":0.00001,"padj":0.00325,"ES":0.97273,"NES":1.6446,"nMoreExtreme":0,"size":133,"leadingEdge":["LRRK2","ANK2","SEC62"]} {"pathway":"GO_TRANSLATIONAL_ELONGATION","pval":0.00001,"padj":0.00325,"ES":0.97437,"NES":1.64183,"nMoreExtreme":0,"size":128,"leadingEdge":["GTPBP1","MRPS10"]} {"pathway":"GO_RIBOSOME_BIOGENESIS","pval":0.00001,"padj":0.00325,"ES":0.92473,"NES":1.63858,"nMoreExtreme":0,"size":275,"leadingEdge":["ISG20","ERI1","BMT2"]} {"pathway":"GO_RRNA_METABOLIC_PROCESS","pval":0.00001,"padj":0.00325,"ES":0.92504,"NES":1.61244,"nMoreExtreme":0,"size":204,"leadingEdge":["ISG20","ERI1","BMT2"]} {"pathway":"GO_NCRNA_PROCESSING","pval":0.00001,"padj":0.00325,"ES":0.89892,"NES":1.61208,"nMoreExtreme":0,"size":361,"leadingEdge":["ISG20","ADAR","LIN28A","ERI1","SMAD3","SEPHS2","TSEN34","BMT2"]} {"pathway":"GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_NONSENSE_MEDIATED_DECAY","pval":0.00001,"padj":0.00325,"ES":0.95393,"NES":1.59497,"nMoreExtreme":0,"size":117,"leadingEdge":["HELZ2","UPF1"]} {"pathway":"GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_ASSEMBLY","pval":0.00001,"padj":0.00325,"ES":0.96687,"NES":1.57535,"nMoreExtreme":0,"size":90,"leadingEdge":["SCO2","NDUFAF7"]} {"pathway":"GO_RESPONSE_TO_INTERFERON_GAMMA","pval":0.00001,"padj":0.00325,"ES":0.91085,"NES":1.56883,"nMoreExtreme":0,"size":170,"leadingEdge":["IRF1","GBP2","GBP5","HLA-DPA1","GBP4","UBD","CD40","GBP1","CIITA","CALCOCO2","SOCS1","HLA-DRA","GCH1","IL12RB1","HLA-DPB1","HLA-DRB1","HLA-F","HLA-DQB1","CCL13","HLA-DRB5","HLA-B","NLRC5","HLA-E","ACOD1","HLA-A","NMI","STAT1","HLA-C","JAK2","NUB1","HLA-DQB2","CCL7","CAMK2D","HLA-DQA1","VCAM1","IFITM2","ICAM1","CCL15","IFITM1","TRIM22","PML","B2M","CCL8","MEFV","RAB20","IRF7","EDN1","GBP6","TRIM31","MT2A","IFITM3","HLA-G","CCL18","CCL5","OAS2","PARP14","OAS3","PARP9","IRF4","KYNU","CXCL16","TLR3","CD47","IFI30","CCL1","CYP27B1","PTAFR","CCL4","NR1H3","FCGR1A","SOCS3","CCL2","PTPN2","CDC42EP2","CCL19","TRIM21","CCL3","IRF5","CX3CL1","TRIM25","CASP1","IRF2","FCGR1B","IRF9"]} {"pathway":"GO_REGULATION_OF_CELLULAR_RESPONSE_TO_HEAT","pval":0.00001,"padj":0.00325,"ES":0.97277,"NES":1.55918,"nMoreExtreme":0,"size":77,"leadingEdge":["CAMK2D","FKBP4"]} {"pathway":"GO_INNATE_IMMUNE_RESPONSE","pval":0.00001,"padj":0.00325,"ES":0.84891,"NES":1.54704,"nMoreExtreme":0,"size":687,"leadingEdge":["IRF1","GBP2","TIFA","GBP5","HLA-DPA1","APOL1","GBP4","UBD","PSME2","AIM2","CD40","GBP1","C4A","CIITA","CALCOCO2","SOCS1","HLA-DRA","GCH1","IL12RB1","SLAMF7","PSMB9","C4B","SERPING1","LAG3","HLA-DPB1","C1QB","HLA-DRB1","NOD2","HLA-F","CEACAM1","HLA-DQB1","CCL13","HLA-DRB5","HLA-B","CFH","NLRC5","PSME1","CFB","HLA-E","ACOD1","ISG20","HLA-A","NMI","OPTN","STAT1","HLA-C","MSRB1","JAK2","PSMB10","NUB1","TRAFD1","HLA-DQB2","IFI27","RIPK2","TLR8","C2","STAT2","CCL7","IL27","PSMB8","IFI35","MCOLN2","CAMK2D","HLA-DQA1","VCAM1","IFITM2","ICAM1","CLEC6A","MUC1","CCL15","APOBEC3D","ZBP1","IFITM1","GSDMD","XAF1","TRIM22","PML","B2M","CCL8","APOBEC3A","C3","SLAMF6","APOBEC3G","CLEC10A","CD300LF","MEFV","IFIT3","TLR10","CTSS","JAK3","CYLD","IFIT2","CASP4","RAB20","IRF7","ICAM2","RSAD2","C1S","EDN1","C1RL","IFIH1","SLAMF1","NCF1","DTX3L","GBP6","LILRA2","TRIM31","DDX60","MT2A","C1R","IFITM3","HLA-G","SLAMF8","RELB","CCL18","CCL5","LYN","IL12A","OAS2","PYHIN1","IFIT5","PARP14","TLR7","TICAM2","CSF1","TNFRSF14","TANK","OAS3","PARP9","CTSL","PLSCR1","IRF4","KYNU","TNFAIP3","CXCL16","LILRA4","BIRC3","MYD88","APOBEC3F","TLR3","CLEC4D","CLEC4E","MR1","PSMA4","PSMA2","SERPINB9","CD226","CUL1","DUSP10","CD47","RASGRP1","PIK3AP1","IFI30","CCL1","CYP27B1","MX1","PTAFR","DDX58","CCL4","NR1H3","LILRB1","FCGR1A","SOCS3","CCL2","PTPN2","DHX58","PAK1","MNDA","SRC","TGFB1","A2M","CDC42EP2","TBKBP1","CCL19","CGAS","WDFY1","C1QC","AKIRIN2","PSMA5","PRDX1","TRIM21","ADAR","IKBKE","PTPN1","NFKBIA","TREML4","IFI6","ADGRB1","ISG15","OTUD4","NCF2","ARID5A","CCL3","IRF5","CX3CL1","USP18","TRIM25","GATA3","CASP1","IRF2","FCGR1B","IRF9"]} {"pathway":"GO_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY","pval":0.00001,"padj":0.00325,"ES":0.88828,"NES":1.54509,"nMoreExtreme":0,"size":197,"leadingEdge":["HLA-DPA1","PSME2","GBP1","HLA-DRA","ITK","PSMB9","CD38","PDE4B","HLA-DPB1","HLA-DRB1","CEACAM1","HLA-DQB1","BTN3A2","HLA-DRB5","PSME1","BTN3A1","CTLA4","PSMB10","HLA-DQB2","RIPK2","BTN3A3","PSMB8","HLA-DQA1","ZC3H12A","CYLD","STAP1","BTN2A2","FYB1","LYN","DENND1B","LILRB4","PSMA4","PSMA2","RBCK1","CD226","CUL1","LCP2","PTPRC","SH2B2","PTPN2","PAK1","MNDA","RUNX1","PSMA5"]} {"pathway":"GO_VIRAL_GENE_EXPRESSION","pval":0.00002,"padj":0.00509,"ES":0.88904,"NES":1.54127,"nMoreExtreme":1,"size":187,"leadingEdge":["TRIM31","IFITM3","CCL5","HPN","CCL4","TRIM21","CCL3","ZFP36","GTF2B","POLR2J"]} {"pathway":"GO_RESPONSE_TO_VIRUS","pval":0.00001,"padj":0.00325,"ES":0.86918,"NES":1.54014,"nMoreExtreme":0,"size":275,"leadingEdge":["IRF1","AIM2","CD40","GBP1","IL12RB1","GBP3","IL15","TBX21","CXCL10","NLRC5","CXCL9","ISG20","STAT1","IFI27","TLR8","BATF3","STAT2","IL27","CYP1A1","IFITM2","RTP4","BCL2L11","APOBEC3D","IFITM1","TSPAN32","TRIM22","PML","CCL8","APOBEC3A","APOBEC3G","IFIT3","ZC3H12A","IFIT2","IRF7","RSAD2","IFI44L","IFIH1","DTX3L","PMAIP1","DDX60","IFITM3","CCL5","IL12A","OAS2","IFIT5","TLR7","OAS3","PARP9","PLSCR1","TNFAIP3","BIRC3","APOBEC3F","IL6","TLR3","TNF","PSMA2","CXCL12","PTPRC","MX1","DDX58","CCL4","LILRB1","DHX58","SRC","IL2RA","CCL19","CGAS","ADAR","IKBKE","IFI6","ISG15","IRF5","TRIM25","IFIT1B","GATA3","IRF2","IL33","IRF9"]} {"pathway":"GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS","pval":0.00002,"padj":0.00509,"ES":0.88421,"NES":1.53873,"nMoreExtreme":1,"size":198,"leadingEdge":["XRN1","SAMD4A","ZC3H12A","HELZ2","ZFP36","BTG2","UPF1"]} {"pathway":"GO_T_CELL_RECEPTOR_SIGNALING_PATHWAY","pval":0.00002,"padj":0.00509,"ES":0.8946,"NES":1.53672,"nMoreExtreme":1,"size":164,"leadingEdge":["HLA-DPA1","PSME2","GBP1","HLA-DRA","ITK","PSMB9","PDE4B","HLA-DPB1","HLA-DRB1","CEACAM1","HLA-DQB1","BTN3A2","HLA-DRB5","PSME1","BTN3A1","PSMB10","HLA-DQB2","RIPK2","BTN3A3","PSMB8","HLA-DQA1","ZC3H12A","CYLD","BTN2A2","FYB1","DENND1B","LILRB4","PSMA4","PSMA2","RBCK1","CD226","CUL1","LCP2","PTPRC","PTPN2","PAK1","PSMA5"]} {"pathway":"GO_DEFENSE_RESPONSE_TO_VIRUS","pval":0.00003,"padj":0.00663,"ES":0.88101,"NES":1.53498,"nMoreExtreme":2,"size":202,"leadingEdge":["IRF1","AIM2","CD40","GBP1","IL12RB1","GBP3","IL15","CXCL10","NLRC5","CXCL9","ISG20","STAT1","IFI27","TLR8","STAT2","IL27","IFITM2","RTP4","APOBEC3D","IFITM1","TSPAN32","TRIM22","PML","APOBEC3A","APOBEC3G","IFIT3","ZC3H12A","IFIT2","IRF7","RSAD2","IFI44L","IFIH1","DTX3L","PMAIP1","DDX60","IFITM3","OAS2","IFIT5","TLR7","OAS3","PARP9","PLSCR1","TNFAIP3","BIRC3","APOBEC3F","IL6","TLR3","PTPRC","MX1","DDX58","LILRB1","DHX58","IL2RA","CGAS","ADAR","IFI6","ISG15","IRF5","TRIM25","IFIT1B","IRF2","IL33","IRF9"]} {"pathway":"GO_FC_EPSILON_RECEPTOR_SIGNALING_PATHWAY","pval":0.00008,"padj":0.01107,"ES":0.9238,"NES":1.53253,"nMoreExtreme":5,"size":107,"leadingEdge":["PSME2","ITK","PSMB9","PSME1","PSMB10","PSMB8","LYN","NR4A3","LILRA4","PSMA4","PSMA2","CUL1","LCP2","PAK1","PSMA5"]} {"pathway":"GO_GENE_SILENCING_BY_RNA","pval":0.00006,"padj":0.00996,"ES":0.89416,"NES":1.53005,"nMoreExtreme":4,"size":155,"leadingEdge":["ZC3H12A","ZNFX1","PIWIL4","MIR503","TDRD9","MOV10","STAT3","TRIM71","TGFB1","ADAR","LIN28A","MIR212","ERI1","SMAD3","ZFP36","MIR155HG","MIR3142HG"]} {"pathway":"GO_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS","pval":0.00006,"padj":0.00996,"ES":0.89605,"NES":1.5294,"nMoreExtreme":4,"size":150,"leadingEdge":["CD74","SOCS1","NLRC5","PADI2","STAT1","JAK2","RIPK2","KLF4","ZBP1","CD300LF","CYLD","CASP4","STAP1","IRF7","CARD16","EDN1","IFIH1","IL1RN","CCL5","PARP14","TICAM2","CSF1","VRK2","PARP9","IL7","TNFAIP3","BIRC3","IL6","TNF","RBCK1","PTPRC","DDX58","NR1H3","SOCS3","PTPN2","RUNX1","ROBO1","IKBKE","PTPN1","OTUD4","CREBRF","SPPL2A","GAS6","USP18","LIFR","CASP1","IL1R2","TRAF1","SLIT2"]} {"pathway":"GO_CHAPERONE_MEDIATED_PROTEIN_FOLDING","pval":0.00001,"padj":0.00334,"ES":0.9982,"NES":1.52863,"nMoreExtreme":0,"size":53,"leadingEdge":["CD74","FKBP4"]} {"pathway":"GO_TRNA_METABOLIC_PROCESS","pval":0.00011,"padj":0.014,"ES":0.88374,"NES":1.51297,"nMoreExtreme":8,"size":156,"leadingEdge":["PPA1","SEPHS2","TSEN34","ELAC2"]} {"pathway":"GO_INTERLEUKIN_1_MEDIATED_SIGNALING_PATHWAY","pval":0.00037,"padj":0.03132,"ES":0.91796,"NES":1.50607,"nMoreExtreme":28,"size":96,"leadingEdge":["PSME2","PSMB9","NOD2","PSME1","PSMB10","RIPK2","PSMB8","IL1RN","VRK2","MYD88","IL6","PSMA4","PSMA2","CUL1","PSMA5","NFKBIA","OTUD4","PLCB1","IL1R2","IL1A","MAP3K8"]} {"pathway":"GO_PROTEIN_SUMOYLATION","pval":0.00028,"padj":0.02706,"ES":0.94251,"NES":1.50464,"nMoreExtreme":20,"size":74,"leadingEdge":["EGR2","IFIH1","HDAC4","MAGEA2"]} {"pathway":"GO_CYTOKINE_MEDIATED_SIGNALING_PATHWAY","pval":0.00001,"padj":0.00325,"ES":0.8255,"NES":1.50278,"nMoreExtreme":0,"size":641,"leadingEdge":["IRF1","GBP2","IL18BP","HLA-DPA1","IL15RA","IL31RA","PSME2","AIM2","CD40","GBP1","CD74","CIITA","SOCS1","HLA-DRA","IL12RB1","CXCL11","PSMB9","IL15","IL32","HLA-DPB1","CXCL10","HLA-DRB1","NOD2","HLA-F","CEACAM1","HLA-DQB1","CCL13","HLA-DRB5","HLA-B","HGF","NLRC5","PSME1","IL3RA","HLA-E","CXCL9","ISG20","HLA-A","NMI","PADI2","STAT1","HLA-C","JAK2","PSMB10","PIM1","HLA-DQB2","IFI27","RIPK2","TNFSF13B","STAT2","CCL7","IL27","ACSL1","PSMB8","IFI35","CAMK2D","HLA-DQA1","VCAM1","IFITM2","ICAM1","MUC1","CCL15","ZBP1","IFITM1","FLT3LG","TNFSF18","CD80","XAF1","TRIM22","PML","CSF2RB","B2M","CCL8","CD300LF","IFIT3","CCRL2","JAK3","CYLD","IFIT2","CASP4","STAP1","IRF7","CARD16","IL12RB2","RSAD2","EDN1","CISH","IL1RN","TRIM31","MT2A","IFITM3","HLA-G","BCL6","CCL18","CCL5","IL12A","OAS2","PARP14","TICAM2","CSF1","LTA","VRK2","TNFRSF14","OAS3","PARP9","IL7","SOD2","IRF4","TNFAIP3","CD70","BIRC3","MYD88","IL6","IL2RG","LTB","TNF","STAT5A","EBI3","PSMA4","PSMA2","RBCK1","CUL1","CD86","IFI30","CCR5","CCL1","CXCL12","PTPRC","MX1","PTAFR","CCL4","NR1H3","ACKR4","KLF6","F3","FCGR1A","SOCS3","CCL2","SH2B2","STAT3","PTPN2","RUNX1","TGFB1","ROBO1","IL2RA","CCL19","CCR6","STAT4","CXCL8","CDKN1A","PSMA5","TRIM21","ADAR","IKBKE","PTPN1","IL17C","NFKBIA","IFI6","MCL1","ISG15","OTUD4","LMNB1","CREBRF","PTGS2","SPPL2A","GAS6","CCL3","IRF5","CX3CL1","USP18","FOXC1","TRIM25","LIFR","GATA3","CASP1","IRF2","TNFRSF6B","IL33","FCGR1B","IRF9"]} {"pathway":"GO_TYPE_I_INTERFERON_PRODUCTION","pval":0.00043,"padj":0.03456,"ES":0.89721,"NES":1.50249,"nMoreExtreme":34,"size":119,"leadingEdge":["IRF1","NLRC5","ACOD1","NMI","STAT1","RIPK2","TLR8","UBE2L6","ZBP1","CYLD","IRF7","IFIH1","RELB","TLR7","TNFAIP3","LILRA4","MYD88","TLR3","NFKB2","DDX58","LILRB1","DHX58","CGAS","TRIM21","IKBKE","ISG15","IRF5","TRIM25"]} {"pathway":"GO_REGULATION_OF_IMMUNE_RESPONSE","pval":0.00001,"padj":0.00325,"ES":0.82162,"NES":1.50003,"nMoreExtreme":0,"size":787,"leadingEdge":["IRF1","TIFA","GBP5","HLA-DPA1","IDO1","PSME2","HLA-DMB","AIM2","CD40","GBP1","C4A","CD74","P2RX7","SOCS1","CD274","HLA-DRA","IL12RB1","ITK","SLAMF7","PSMB9","C4B","CD38","IL15","SERPING1","LAG3","PDE4B","HLA-DPB1","TBX21","C1QB","HLA-DRB1","NOD2","CLEC2B","HLA-F","CEACAM1","HLA-DQB1","BTN3A2","HLA-DRB5","HLA-B","CFH","SELL","NLRC5","PSME1","CFB","BTN3A1","HLA-E","ACOD1","HLA-A","NMI","STAT1","CTLA4","HLA-C","JAK2","PSMB10","TRAFD1","HLA-DQB2","RIPK2","TLR8","BTN3A3","C2","TNFSF13B","IL27","PSMB8","HLA-DQA1","VCAM1","ICAM1","CLEC6A","MUC1","ZBP1","IFITM1","CD80","B2M","C3","SLAMF6","CLEC10A","CD300LF","TLR10","ZC3H12A","CTSS","JAK3","CYLD","STAP1","IRF7","ICAM2","RSAD2","LILRA1","BTN2A2","C1S","C1RL","IFIH1","LILRA2","DDX60","C1R","HLA-G","FYB1","SLAMF8","RELB","BCL6","CCL5","LYN","IL12A","PYHIN1","PARP14","TLR7","TICAM2","LTA","NR4A3","TNFRSF14","TANK","PARP3","PARP9","CTSL","PLSCR1","IRF4","DENND1B","TNFAIP3","ICAM4","LILRA4","BIRC3","MYD88","IL6","TLR3","CLEC4D","CLEC4E","LILRB4","SEMA7A","TNF","PSMA4","PSMA2","SERPINB9","RBCK1","CD226","CUL1","DUSP10","CD86","CD47","RASGRP1","PIK3AP1","ITGAL","LCP2","PTPRC","PTAFR","DDX58","NR1H3","LILRB1","FPR2","KLRC1","FCGR1A","SOCS3","SH2B2","PTPN2","ITGB7","DHX58","PAK1","MNDA","RUNX1","SRC","TGFB1","A2M","IL2RA","CCL19","CGAS","WDFY1","C1QC","PSMA5","IKBKE","PTPN1","NFKBIA","TREML4","OTUD4","CD48","SPPL2A"]} {"pathway":"GO_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION","pval":0.00055,"padj":0.04155,"ES":0.9052,"NES":1.49875,"nMoreExtreme":43,"size":105,"leadingEdge":["EAF1","TAF1A","ELL2","MLLT3","POLR2J"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_HEAT","pval":0.00048,"padj":0.03804,"ES":0.8939,"NES":1.49809,"nMoreExtreme":38,"size":120,"leadingEdge":["CXCL10","MYOF","CAMK2D","HSBP1L1","LYN","TFEC","CDKN1A","PTGS2","TCIM","IL1A"]} {"pathway":"GO_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE","pval":0.00001,"padj":0.00325,"ES":0.82271,"NES":1.49716,"nMoreExtreme":0,"size":627,"leadingEdge":["IRF1","TIFA","GBP5","HLA-DPA1","IDO1","PSME2","HLA-DMB","AIM2","CD40","GBP1","C4A","CD74","P2RX7","CD274","HLA-DRA","IL12RB1","ITK","PSMB9","C4B","CD38","IL15","SERPING1","LAG3","PDE4B","HLA-DPB1","TBX21","C1QB","HLA-DRB1","NOD2","HLA-F","CEACAM1","HLA-DQB1","BTN3A2","HLA-DRB5","HLA-B","CFH","NLRC5","PSME1","CFB","BTN3A1","HLA-E","ACOD1","HLA-A","CTLA4","HLA-C","PSMB10","HLA-DQB2","RIPK2","TLR8","BTN3A3","C2","TNFSF13B","PSMB8","HLA-DQA1","CLEC6A","MUC1","ZBP1","CD80","B2M","C3","SLAMF6","CLEC10A","CD300LF","TLR10","ZC3H12A","CTSS","CYLD","STAP1","IRF7","ICAM2","RSAD2","BTN2A2","C1S","C1RL","IFIH1","LILRA2","DDX60","C1R","HLA-G","FYB1","RELB","CCL5","LYN","IL12A","PYHIN1","TLR7","TICAM2","LTA","NR4A3","TNFRSF14","TANK","PARP9","CTSL","PLSCR1","IRF4","DENND1B","TNFAIP3","LILRA4","BIRC3","MYD88","IL6","TLR3","CLEC4D","CLEC4E","LILRB4","SEMA7A","TNF","PSMA4","PSMA2","RBCK1","CD226","CUL1","CD86","CD47","RASGRP1","PIK3AP1","LCP2","PTPRC","PTAFR","DDX58","NR1H3","LILRB1","FPR2","FCGR1A","SH2B2","PTPN2","DHX58","PAK1","MNDA","RUNX1","SRC","TGFB1","A2M","CCL19","CGAS","WDFY1","C1QC","PSMA5"]} {"pathway":"GO_ACTIVATION_OF_IMMUNE_RESPONSE","pval":0.00001,"padj":0.00325,"ES":0.82521,"NES":1.49303,"nMoreExtreme":0,"size":482,"leadingEdge":["IRF1","TIFA","HLA-DPA1","PSME2","AIM2","GBP1","C4A","HLA-DRA","ITK","PSMB9","C4B","CD38","SERPING1","PDE4B","HLA-DPB1","C1QB","HLA-DRB1","NOD2","CEACAM1","HLA-DQB1","BTN3A2","HLA-DRB5","CFH","PSME1","CFB","BTN3A1","ACOD1","CTLA4","PSMB10","HLA-DQB2","RIPK2","TLR8","BTN3A3","C2","PSMB8","HLA-DQA1","CLEC6A","MUC1","C3","CLEC10A","CD300LF","TLR10","ZC3H12A","CTSS","CYLD","STAP1","IRF7","ICAM2","RSAD2","BTN2A2","C1S","C1RL","IFIH1","LILRA2","DDX60","C1R","FYB1","RELB","LYN","PYHIN1","TLR7","TICAM2","NR4A3","TANK","CTSL","PLSCR1","IRF4","DENND1B","TNFAIP3","LILRA4","BIRC3","MYD88","TLR3","CLEC4D","CLEC4E","LILRB4","PSMA4","PSMA2","RBCK1","CD226","CUL1","CD47","PIK3AP1","LCP2","PTPRC","DDX58","NR1H3","FPR2","FCGR1A","SH2B2","PTPN2","DHX58","PAK1","MNDA","RUNX1","SRC","A2M","CGAS","WDFY1","C1QC","PSMA5","IKBKE","NFKBIA","TREML4","OTUD4"]} {"pathway":"GO_INTERFERON_GAMMA_MEDIATED_SIGNALING_PATHWAY","pval":0.00057,"padj":0.04198,"ES":0.92575,"NES":1.49041,"nMoreExtreme":42,"size":80,"leadingEdge":["IRF1","GBP2","HLA-DPA1","GBP1","CIITA","SOCS1","HLA-DRA","HLA-DPB1","HLA-DRB1","HLA-F","HLA-DQB1","HLA-DRB5","HLA-B","NLRC5","HLA-E","HLA-A","NMI","STAT1","HLA-C","JAK2","HLA-DQB2","CAMK2D","HLA-DQA1","VCAM1","ICAM1","TRIM22","PML","B2M","IRF7","TRIM31","MT2A","HLA-G","OAS2","PARP14","OAS3","PARP9","IRF4","IFI30","PTAFR","NR1H3","FCGR1A","SOCS3","PTPN2","TRIM21","IRF5","TRIM25","IRF2","FCGR1B","IRF9"]} {"pathway":"GO_RESPONSE_TO_HEAT","pval":0.00042,"padj":0.0337,"ES":0.87152,"NES":1.48754,"nMoreExtreme":34,"size":150,"leadingEdge":["CXCL10","MYOF","CAMK2D","HSBP1L1","LYN","TFEC","CXCL12","GCLC","CDKN1A","PTGS2","TCIM","MICB","IL1A"]} {"pathway":"GO_RESPONSE_TO_TYPE_I_INTERFERON","pval":0.00079,"padj":0.0539,"ES":0.92331,"NES":1.48451,"nMoreExtreme":59,"size":79,"leadingEdge":["IRF1","GBP2","HLA-F","HLA-B","NLRC5","HLA-E","ISG20","HLA-A","STAT1","HLA-C","IFI27","STAT2","PSMB8","IFI35","IFITM2","ZBP1","IFITM1","XAF1","IFIT3","IFIT2","IRF7","RSAD2","IFITM3","HLA-G","OAS2","OAS3","IRF4","MYD88","MX1","PTPN2","ADAR","IKBKE","PTPN1","IFI6","ISG15","IRF5","USP18","IRF2","IRF9"]} {"pathway":"GO_REGULATION_OF_INNATE_IMMUNE_RESPONSE","pval":0.00001,"padj":0.00325,"ES":0.82663,"NES":1.48266,"nMoreExtreme":0,"size":362,"leadingEdge":["IRF1","TIFA","GBP5","PSME2","AIM2","SOCS1","PSMB9","SERPING1","LAG3","NOD2","HLA-F","CEACAM1","NLRC5","PSME1","HLA-E","ACOD1","NMI","STAT1","JAK2","PSMB10","TRAFD1","RIPK2","TLR8","PSMB8","CLEC6A","MUC1","ZBP1","SLAMF6","CLEC10A","CD300LF","TLR10","CTSS","CYLD","IRF7","ICAM2","RSAD2","IFIH1","LILRA2","DDX60","HLA-G","SLAMF8","RELB","CCL5","LYN","IL12A","PYHIN1","PARP14","TLR7","TICAM2","TANK","PARP9","CTSL","PLSCR1","IRF4","TNFAIP3","LILRA4","BIRC3","MYD88","TLR3","CLEC4D","CLEC4E","PSMA4","PSMA2","SERPINB9","CD226","CUL1","DUSP10","RASGRP1","PIK3AP1","DDX58","NR1H3","LILRB1","SOCS3","PTPN2","DHX58","PAK1","MNDA","SRC","A2M","CGAS","WDFY1","PSMA5","IKBKE","PTPN1","NFKBIA","TREML4","OTUD4"]} {"pathway":"GO_RESPONSE_TO_INTERLEUKIN_1","pval":0.0003,"padj":0.02801,"ES":0.85915,"NES":1.48183,"nMoreExtreme":25,"size":174,"leadingEdge":["GBP2","PSME2","CD40","GBP1","GBP3","PSMB9","CD38","NOD2","CCL13","PSME1","ACOD1","PSMB10","RIPK2","CCL7","PSMB8","ICAM1","CCL15","CCL8","ZC3H12A","EDN1","IL1RN","CCL18","CCL5","VRK2","TANK","MYD88","IL6","PSMA4","PSMA2","CUL1","CD47","CCL1","CHI3L1","CCL4","CCL2","KMO","GCLC","SRC","CCL19","CXCL8","PSMA5","NFKBIA","OTUD4","HAS2","CCL3","CX3CL1","NKX3-1","PLCB1","IL1R2","IL1A","MAP3K8"]} {"pathway":"GO_LIPOPROTEIN_BIOSYNTHETIC_PROCESS","pval":0.0011,"padj":0.06757,"ES":0.91337,"NES":1.48136,"nMoreExtreme":83,"size":86,"leadingEdge":["ZDHHC19","GLUL","ZDHHC18","ZDHHC11B","PIGY","ZDHHC23","DPM1"]} {"pathway":"GO_REGULATION_OF_ANTIMICROBIAL_HUMORAL_RESPONSE","pval":0.02521,"padj":0.40148,"ES":0.99225,"NES":1.48,"nMoreExtreme":1266,"size":2,"leadingEdge":["ACOD1","PPP2R3C"]} {"pathway":"GO_SOMATOSTATIN_RECEPTOR_SIGNALING_PATHWAY","pval":0.02854,"padj":0.42091,"ES":0.99124,"NES":1.47849,"nMoreExtreme":1433,"size":2,"leadingEdge":["SSTR2","SSTR1"]} {"pathway":"GO_PROTEIN_TARGETING_TO_MEMBRANE","pval":0.00033,"padj":0.02877,"ES":0.85366,"NES":1.4771,"nMoreExtreme":27,"size":182,"leadingEdge":["RTP4","NCF1","ZDHHC19","ZDHHC18","ZDHHC11B","ATG3","KCNE1","PAK1","STOM","ZDHHC23"]} {"pathway":"GO_TRNA_MODIFICATION","pval":0.00139,"padj":0.07928,"ES":0.91362,"NES":1.47656,"nMoreExtreme":105,"size":83,"leadingEdge":["SEPHS2","NSUN2"]} {"pathway":"GO_REGULATION_OF_CELLULAR_AMINE_METABOLIC_PROCESS","pval":0.00087,"padj":0.05637,"ES":0.93544,"NES":1.47565,"nMoreExtreme":63,"size":67,"leadingEdge":["PSME2","PSMB9","PSME1","PSMB10","PSMB8","PSMA4","PSMA2","NR4A2","PSMA5"]} {"pathway":"GO_IMMUNE_RESPONSE_REGULATING_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY","pval":0.00001,"padj":0.00325,"ES":0.82622,"NES":1.47485,"nMoreExtreme":0,"size":322,"leadingEdge":["HLA-DPA1","PSME2","CD40","GBP1","HLA-DRA","ITK","PSMB9","CD38","PDE4B","HLA-DPB1","HLA-DRB1","CEACAM1","HLA-DQB1","BTN3A2","HLA-DRB5","PSME1","BTN3A1","CTLA4","PSMB10","HLA-DQB2","RIPK2","BTN3A3","PSMB8","HLA-DQA1","CLEC6A","MUC1","CLEC10A","ZC3H12A","CYLD","STAP1","ICAM2","BTN2A2","LILRA2","HLA-G","FYB1","RELB","LYN","NR4A3","PLSCR1","DENND1B","LILRA4","CLEC4D","CLEC4E","LILRB4","PSMA4","PSMA2","RBCK1","CD226","CUL1","CD47","LCP2","PTPRC","LILRB1","FPR2","FCGR1A","SH2B2","PTPN2","PAK1","MNDA","RUNX1","SRC","PSMA5"]} {"pathway":"GO_MACROMOLECULE_DEACYLATION","pval":0.00162,"padj":0.08806,"ES":0.90514,"NES":1.47477,"nMoreExtreme":124,"size":90,"leadingEdge":["LRRK2","CAMK2D","BCL6","TGFB1","HDAC4"]} {"pathway":"GO_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS","pval":0.00001,"padj":0.00325,"ES":0.82639,"NES":1.47451,"nMoreExtreme":0,"size":318,"leadingEdge":["HLA-DMB","AIM2","CD40","C4A","CD74","P2RX7","IL12RB1","C4B","IL15","SERPING1","LAG3","TBX21","C1QB","NOD2","HLA-F","CEACAM1","HLA-B","CFH","CFB","HLA-E","HLA-A","STAT1","HLA-C","RIPK2","C2","IL27","CD80","TSPAN32","B2M","C3","SLAMF6","APOBEC3G","ZC3H12A","JAK3","RSAD2","C1S","DTX3L","DDX60","C1R","HLA-G","SLAMF8","BCL6","LYN","IL12A","LTA","NR4A3","TNFRSF14","PARP3","PARP9","IRF4","TNFAIP3","BIRC3","APOBEC3F","IL6","TLR3","SEMA7A","TNF","SERPINB9","CD226","DUSP10","CD86","CD47","RASGRP1","PTPRC","PTAFR","DDX58","LILRB1","DHX58","TGFB1","A2M","IL2RA","CCL19","CGAS","C1QC"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION","pval":0.00126,"padj":0.07505,"ES":0.91976,"NES":1.47421,"nMoreExtreme":94,"size":77,"leadingEdge":["IRF1","CD74","SOCS1","TBX21","CEACAM1","CTLA4","TMEM176A","TMEM176B","LILRB3","ZC3H12A","JAK3","HLA-G","BCL6","LYN","TLR3","LILRB4","LILRB1","PTPN2","RUNX1","C1QC","CCL3"]} {"pathway":"GO_DEFENSE_RESPONSE_TO_OTHER_ORGANISM","pval":0.00001,"padj":0.00325,"ES":0.82333,"NES":1.47033,"nMoreExtreme":0,"size":325,"leadingEdge":["IRF1","IL31RA","AIM2","CD40","GBP1","P2RX7","CALCOCO2","IL12RB1","GBP3","IL15","CXCL10","NOD2","NLRC5","HLA-E","BATF2","CXCL9","ISG20","OPTN","STAT1","IFI27","RIPK2","TLR8","STAT2","IL27","IFITM2","RTP4","CLEC6A","APOBEC3D","IFITM1","GSDMD","TSPAN32","TRIM22","PML","APOBEC3A","APOBEC3G","IFIT3","ZC3H12A","IFIT2","IRF7","RSAD2","IFI44L","IFIH1","DTX3L","GBP6","PMAIP1","DDX60","IFITM3","SLAMF8","IL12A","OAS2","IFIT5","TLR7","LTA","TNFRSF14","OAS3","PARP9","PLSCR1","IRF4","TNFAIP3","ANXA3","BIRC3","MYD88","APOBEC3F","IL6","TLR3","CLEC4D","CLEC4E","TNF","MR1","VGF","PTPRC","MX1","DDX58","LILRB1","DHX58","TGFB1","CCDC88B","IL2RA","CGAS","ADAR","IFI6","ADGRB1","ISG15","IRF5","TRIM25","IFIT1B","MPEG1","IRF2","IL33","IRF9"]} {"pathway":"GO_IMMUNE_RESPONSE_REGULATING_SIGNALING_PATHWAY","pval":0.00001,"padj":0.00325,"ES":0.81338,"NES":1.47013,"nMoreExtreme":0,"size":461,"leadingEdge":["IRF1","TIFA","HLA-DPA1","PSME2","CD40","GBP1","HLA-DRA","ITK","PSMB9","CD38","PDE4B","HLA-DPB1","HLA-DRB1","NOD2","CEACAM1","HLA-DQB1","BTN3A2","HLA-DRB5","PSME1","BTN3A1","ACOD1","CTLA4","PSMB10","HLA-DQB2","RIPK2","TLR8","BTN3A3","PSMB8","HLA-DQA1","CLEC6A","MUC1","CLEC10A","CD300LF","TLR10","ZC3H12A","CTSS","CYLD","STAP1","IRF7","ICAM2","RSAD2","BTN2A2","IFIH1","LILRA2","DDX60","HLA-G","FYB1","RELB","LYN","TLR7","TICAM2","NR4A3","TANK","CTSL","PLSCR1","IRF4","DENND1B","TNFAIP3","LILRA4","BIRC3","MYD88","TLR3","CLEC4D","CLEC4E","LILRB4","PSMA4","PSMA2","RBCK1","CD226","CUL1","CD47","PIK3AP1","LCP2","PTPRC","DDX58","NR1H3","LILRB1","FPR2","FCGR1A","SH2B2","PTPN2","DHX58","PAK1","MNDA","RUNX1","SRC","WDFY1","PSMA5","IKBKE","NFKBIA","TREML4","OTUD4"]} {"pathway":"GO_LIPID_HYDROXYLATION","pval":0.04913,"padj":0.54897,"ES":0.98506,"NES":1.46928,"nMoreExtreme":2468,"size":2,"leadingEdge":["CYP1A1","CYP3A5"]} {"pathway":"GO_PHENYLPROPANOID_METABOLIC_PROCESS","pval":0.04913,"padj":0.54897,"ES":0.98506,"NES":1.46928,"nMoreExtreme":2468,"size":2,"leadingEdge":["CYP1A1","CYP2D6"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_IMMUNE_RESPONSE","pval":0.0016,"padj":0.08793,"ES":0.88239,"NES":1.46828,"nMoreExtreme":127,"size":111,"leadingEdge":["SERPING1","TBX21","HLA-F","CEACAM1","NLRC5","HLA-E","ACOD1","NMI","TRAFD1","ZC3H12A","JAK3","HLA-G","SLAMF8","BCL6","LYN","PARP14","TNFRSF14","PARP3","TNFAIP3","TNF","SERPINB9","DUSP10","PTPRC","NR1H3","LILRB1","PTPN2","DHX58","TGFB1","A2M","IL2RA"]} {"pathway":"GO_ADENYLATE_CYCLASE_INHIBITING_G_PROTEIN_COUPLED_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY","pval":0.05667,"padj":0.57014,"ES":0.98276,"NES":1.46584,"nMoreExtreme":2847,"size":2,"leadingEdge":["GRM8","GRM6"]} {"pathway":"GO_AMINE_METABOLIC_PROCESS","pval":0.00177,"padj":0.09323,"ES":0.88132,"NES":1.46562,"nMoreExtreme":140,"size":110,"leadingEdge":["IDO1","PSME2","PSMB9","PSME1","IDO2","PSMB10","PSMB8","VCAM1","CYP1A1","SULT1C2","SAT1","KYNU","PSMA4","PSMA2","AZIN2","NR4A2","KMO","PSMA5"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELL_CELL_ADHESION","pval":0.00103,"padj":0.06389,"ES":0.86375,"NES":1.46522,"nMoreExtreme":84,"size":139,"leadingEdge":["IRF1","IDO1","CD74","SOCS1","CD274","PDCD1LG2","LAG3","TBX21","CEACAM1","CTLA4","JAK2","KLF4","CD80","ZC3H12A","JAK3","BTN2A2","IL1RN","HLA-G","BCL6","TNFRSF14","CD86","CXCL12","LILRB1","PTPN2","PODXL","RUNX1","TGFB1","IL2RA"]} {"pathway":"GO_POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS","pval":0.00001,"padj":0.00325,"ES":0.80096,"NES":1.46334,"nMoreExtreme":0,"size":851,"leadingEdge":["IRF1","TIFA","GBP5","HLA-DPA1","IDO1","PSME2","HLA-DMB","AIM2","CD40","GBP1","C4A","CD74","P2RX7","SOCS1","CD274","LRRK2","HLA-DRA","IL12RB1","ITK","PSMB9","C4B","CD38","PDCD1LG2","IL15","SERPING1","LAG3","PDE4B","HLA-DPB1","TBX21","C1QB","CXCL10","HLA-DRB1","NOD2","HLA-F","CEACAM1","HLA-DQB1","BTN3A2","HLA-DRB5","HLA-B","CFH","NLRC5","PSME1","CFB","BTN3A1","HLA-E","ACOD1","HLA-A","STAT1","CTLA4","HLA-C","HCAR2","PSMB10","HLA-DQB2","RIPK2","TLR8","BTN3A3","C2","TNFSF13B","CCL7","PSMB8","HLA-DQA1","VCAM1","ICAM1","CLEC6A","MUC1","ZBP1","FLT3LG","TNFSF18","CD80","PDCD1","B2M","CCL8","C3","SLAMF6","CLEC10A","CD300LF","TLR10","ZC3H12A","CTSS","JAK3","CYLD","P2RX4","STAP1","SCIN","IRF7","ICAM2","RSAD2","BTN2A2","C1S","EDN1","C1RL","VEGFC","IFIH1","LILRA2","DDX60","DYSF","C1R","HLA-G","FYB1","RELB","BCL6","CCL5","LYN","IL12A","PYHIN1","TLR7","TICAM2","CSF1","LTA","NR4A3","TNFRSF14","TANK","PARP9","IL7","CTSL","PLSCR1","CD83","IRF4","DENND1B","TNFAIP3","LILRA4","BIRC3","MYD88","IL6","TLR3","CLEC4D","CLEC4E","LILRB4","FGF10","EGR3","SEMA7A","TNF","EBI3","PSMA4","PSMA2","RBCK1","CD226","CUL1","DUSP10","CD86","CD47","RASGRP1","PIK3AP1","CAMK1D","CCL1","CXCL12","LCP2","PTPRC","PTAFR","DDX58","CCL4","NR1H3","LILRB1","FPR2","FCGR1A","CCL2","SH2B2","STAT3","P2RY12","PTPN2","DHX58","PAK1","MNDA","RUNX1","SRC","TGFB1","A2M","ICOS","OCSTAMP","CCDC88B","IL2RA","CCL19","CGAS","CCR6","WDFY1","C1QC","CXCL8","PSMA5"]} {"pathway":"GO_DEFENSE_RESPONSE","pval":0.00001,"padj":0.00325,"ES":0.79855,"NES":1.46224,"nMoreExtreme":0,"size":1201,"leadingEdge":["IRF1","GBP2","TIFA","GBP5","HLA-DPA1","APOL1","GBP4","APOL3","IL31RA","IDO1","UBD","PSME2","TAP1","AIM2","CD40","GBP1","C4A","CD74","P2RX7","CIITA","CALCOCO2","SOCS1","LRRK2","HLA-DRA","GCH1","IL12RB1","ITK","CXCL11","GBP3","SLAMF7","PSMB9","C4B","IL15","SERPING1","IL32","APOL2","LAG3","HLA-DPB1","C1QB","CXCL10","HLA-DRB1","NOD2","HLA-F","CEACAM1","ADGRE5","HLA-DQB1","CCL13","HLA-DRB5","HLA-B","CFH","HGF","NLRC5","PSME1","CFB","HLA-E","ACOD1","BATF2","CXCL9","ISG20","HLA-A","NMI","OPTN","STAT1","HLA-C","MSRB1","JAK2","SUCNR1","PSMB10","NUB1","AGT","TRAFD1","HLA-DQB2","IFI27","RIPK2","TLR8","C2","STAT2","CCL7","IL27","PSMB8","IFI35","MCOLN2","CAMK2D","HLA-DQA1","VCAM1","IFITM2","ICAM1","RTP4","KLF4","CLEC6A","MUC1","CCL15","APOBEC3D","ZBP1","TGM2","LILRB3","IFITM1","GSDMD","SP140","XAF1","TSPAN32","TRIM22","PML","B2M","CCL8","APOBEC3A","C3","SLAMF6","APOBEC3G","CLEC10A","CD300LF","MEFV","IFIT3","TLR10","ZC3H12A","CCRL2","CTSS","JAK3","CYLD","LGALS3BP","IFIT2","CASP4","STAP1","RAB20","IRF7","ICAM2","RSAD2","LILRA1","IFI44L","C1S","EDN1","C1RL","IFIH1","SLAMF1","NCF1","DTX3L","GBP6","PMAIP1","LILRA2","IL1RN","SBNO2","LY75","TRIM31","DDX60","MT2A","C1R","IFITM3","HLA-G","SLAMF8","POLB","GGT5","PTGER4","RELB","BCL6","CCL18","CCL5","LYN","IL12A","OAS2","PYHIN1","IFIT5","TNFAIP6","MMP25","PARP14","TLR7","TICAM2","CSF1","LTA","TNFRSF14","TANK","OAS3","PARP9","CTSL","PLSCR1","CD83","IRF4","KYNU","TNFAIP3","ANXA3","CXCL16","LILRA4","BIRC3","MYD88","APOBEC3F","PLA2G4C","IL6","TLR3","CLEC4D","CLEC4E","SEMA7A","TNF","PTGER2","MR1","PSMA4","PSMA2","SERPINB9","VGF","CD226","CUL1","DUSP10","CD47","RASGRP1","SCN9A","PIK3AP1","IFI30","CAMK1D","CCR5","CCL1","ITGAL","CXCL12","CYP27B1","PTPRC","CHI3L1","MX1","PTAFR","DDX58","CCL4","NR1H3","LILRB1","FPR2","F3","FCGR1A","SOCS3","CCL2","STAT3","PTPN2","DHX58","PAK1","MNDA","SRC","TGFB1","A2M","CDC42EP2","CCDC88B","TBKBP1","IL2RA","CCL19","CGAS","CCR6","WDFY1","C1QC","CXCL8","AKIRIN2","PSMA5","PRDX1","NAMPT","TRIM21","ADAR","IKBKE","SLC7A2","PTPN1","IL17C","NFKBIA","TREML4","IFI6","ADGRB1","ISG15","OTUD4","PLGRKT","PTGS2","CHST2","CD48","NCF2","ARID5A","CCL3","IRF5","CX3CL1","USP18","TRIM25","IFIT1B","GATA3","CASP1","MPEG1","IRF2","NFE2L2","IL33","FCGR1B","IRF9"]} {"pathway":"GO_POSITIVE_REGULATION_OF_COMPLEMENT_ACTIVATION","pval":0.06531,"padj":0.60364,"ES":0.98034,"NES":1.46224,"nMoreExtreme":3281,"size":2,"leadingEdge":["C3","PHB"]} {"pathway":"GO_REGULATION_OF_MEIOSIS_I","pval":0.07122,"padj":0.62112,"ES":0.97849,"NES":1.45947,"nMoreExtreme":3578,"size":2,"leadingEdge":["HORMAD1","UBE2B"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_REGULATORY_T_CELL_DIFFERENTIATION","pval":0.03767,"padj":0.49791,"ES":0.99062,"NES":1.45947,"nMoreExtreme":1925,"size":3,"leadingEdge":["IRF1","CTLA4"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_ACTIVATION","pval":0.00195,"padj":0.0971,"ES":0.8725,"NES":1.45883,"nMoreExtreme":156,"size":117,"leadingEdge":["IRF1","IDO1","CD74","SOCS1","CD274","PDCD1LG2","LAG3","TBX21","HLA-F","CEACAM1","BANK1","CTLA4","CD80","ZC3H12A","JAK3","BTN2A2","HLA-G","BCL6","LYN","TNFRSF14","PARP3","TNFAIP3","CD86","LILRB1","PTPN2","MNDA","RUNX1","TGFB1","IL2RA"]} {"pathway":"GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_I","pval":0.00304,"padj":0.12995,"ES":0.89301,"NES":1.45862,"nMoreExtreme":235,"size":92,"leadingEdge":["TAP2","PSME2","TAP1","PSMB9","ERAP2","HLA-F","HLA-B","PSME1","HLA-E","HLA-A","HLA-C","PSMB10","TAPBP","PSMB8","B2M","NCF1","TAPBPL","HLA-G","MR1","PSMA4","PSMA2","IFI30","FCGR1A","PSMA5","NCF2","FCGR1B","ERAP1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_CELL_CELL_ADHESION","pval":0.00293,"padj":0.12586,"ES":0.88615,"NES":1.45841,"nMoreExtreme":229,"size":99,"leadingEdge":["IRF1","IDO1","CD74","SOCS1","CD274","PDCD1LG2","LAG3","TBX21","CEACAM1","CTLA4","KLF4","CD80","ZC3H12A","JAK3","BTN2A2","HLA-G","BCL6","TNFRSF14","CD86","CXCL12","LILRB1","PTPN2","RUNX1","TGFB1","IL2RA","RIPOR2"]} {"pathway":"GO_ADAPTIVE_IMMUNE_RESPONSE_BASED_ON_SOMATIC_RECOMBINATION_OF_IMMUNE_RECEPTORS_BUILT_FROM_IMMUNOGLOBULIN_SUPERFAMILY_DOMAINS","pval":0.00034,"padj":0.02981,"ES":0.8346,"NES":1.45821,"nMoreExtreme":29,"size":212,"leadingEdge":["IL18BP","IL31RA","CD40","C4A","CD74","P2RX7","CD274","IL12RB1","C4B","SERPING1","TBX21","C1QB","HLA-F","CEACAM1","HLA-DQB1","BTN3A2","HLA-B","HLA-E","HLA-A","HLA-C","RIPK2","TLR8","BTN3A3","C2","TNFSF13B","IL27","ICAM1","CD80","B2M","C3","SLAMF6","ZC3H12A","JAK3","IRF7","RSAD2","C1S","C1RL","C1R","HLA-G","GCNT3","RELB","BCL6","IL12A","LTA","PARP3","IRF4","DENND1B","TNFAIP3","IL6","NFKB2","TNF","EBI3","CD226","PTPRC","LILRB1","STAT3","NBN","TGFB1","SEMA4A","CCL19","CCR6","C1QC","CTSC"]} {"pathway":"GO_DRINKING_BEHAVIOR","pval":0.04311,"padj":0.52235,"ES":0.98938,"NES":1.45765,"nMoreExtreme":2203,"size":3,"leadingEdge":["AGT","HTR1B"]} {"pathway":"GO_RESPONSE_TO_BIOTIC_STIMULUS","pval":0.00001,"padj":0.00325,"ES":0.79839,"NES":1.45556,"nMoreExtreme":0,"size":708,"leadingEdge":["IRF1","IL18BP","GBP5","IL31RA","IDO1","AIM2","CD40","GBP1","P2RX7","CALCOCO2","CD274","GCH1","IL12RB1","CXCL11","GBP3","C4B","PDCD1LG2","IL15","PDE4B","TBX21","CXCL10","NOD2","CEACAM1","CCL13","NLRC5","HLA-E","ACOD1","BATF2","BANK1","CXCL9","ISG20","OPTN","STAT1","JAK2","IFI27","RIPK2","PLAAT3","TLR8","BATF3","STAT2","IL27","VCAM1","CYP1A1","IFITM2","ICAM1","RTP4","BCL2L11","CLEC6A","APOBEC3D","IFITM1","CD80","GSDMD","TSPAN32","TRIM22","PML","FAM20A","CSF2RB","B2M","CCL8","APOBEC3A","C3","APOBEC3G","IFIT3","ZC3H12A","IFIT2","CARD17","STAP1","IRF7","CARD16","IL12RB2","RSAD2","IFI44L","EDN1","IFIH1","C15orf48","DTX3L","GBP6","PMAIP1","LILRA2","IL1RN","SBNO2","DDX60","IFITM3","SLAMF8","TMEM255A","PTGER4","CMPK2","LITAF","CCL5","LYN","IL12A","OAS2","IFIT5","TLR7","TICAM2","LTA","TNFRSF14","OAS3","PLSCR4","PARP9","PLSCR1","IRF4","TNFAIP3","ANXA3","BIRC3","TMEM229B","OCIAD2","MYD88","APOBEC3F","IL6","TLR3","CLEC4D","CLEC4E","FGF10","NFKB2","TNF","PTGER2","MR1","PSMA2","SERPINB9","VGF","CD226","DUSP10","CD86","CD47","CCR5","CXCL12","CYP27B1","PTPRC","MX1","PTAFR","DDX58","CCL4","NR1H3","LILRB1","CCL2","KMO","DHX58","SRC","TGFB1","CCDC88B","IL2RA","CCL19","CGAS","CXCL8","AKIRIN2","TXNIP","ADAR","IKBKE","GUCY1A1","NFKBIA","IFI6","ADGRB1","ISG15","PTGS2","CCL3","RGS1","IRF5","CX3CL1","TRIM25","CFLAR","IFIT1B","GATA3","CASP1","MPEG1","IRF2","IL33","IRF9"]} {"pathway":"GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN","pval":0.00082,"padj":0.05464,"ES":0.84308,"NES":1.4541,"nMoreExtreme":69,"size":174,"leadingEdge":["HLA-DPA1","HLA-DMA","TAP2","PSME2","TAP1","HLA-DMB","CD74","HLA-DOA","HLA-DRA","PSMB9","LAG3","HLA-DPB1","ERAP2","HLA-DRB1","HLA-F","HLA-DQB1","HLA-DRB5","HLA-B","PSME1","HLA-E","HLA-A","HLA-C","PSMB10","HLA-DQB2","TAPBP","PSMB8","HLA-DOB","HLA-DQA1","B2M","CTSS","NCF1","TAPBPL","HLA-G","CTSL","MR1","PSMA4","PSMA2","IFI30","FCGR1A"]} {"pathway":"GO_PROTEIN_TRANSMEMBRANE_TRANSPORT","pval":0.00196,"padj":0.0971,"ES":0.93695,"NES":1.45201,"nMoreExtreme":140,"size":58,"leadingEdge":["MCL1","SEC62"]} {"pathway":"GO_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER","pval":0.00394,"padj":0.15223,"ES":0.90292,"NES":1.45173,"nMoreExtreme":297,"size":79,"leadingEdge":["EAF1","ELL2","MLLT3","POLR2J"]} {"pathway":"GO_NCRNA_METABOLIC_PROCESS","pval":0.00003,"padj":0.00643,"ES":0.80538,"NES":1.45083,"nMoreExtreme":2,"size":411,"leadingEdge":["ISG20","PPA1","PIWIL4","TDRD9","TRIM71","ADAR","LIN28A","ERI1","SMAD3","SEPHS2","TSEN34"]} {"pathway":"GO_MRNA_TRANSPORT","pval":0.0016,"padj":0.08793,"ES":0.85427,"NES":1.45074,"nMoreExtreme":132,"size":141,"leadingEdge":["MVP","PARP11","ZFP36","ARC","UPF1"]} {"pathway":"GO_ADAPTIVE_IMMUNE_RESPONSE","pval":0.00003,"padj":0.00646,"ES":0.81467,"NES":1.4506,"nMoreExtreme":2,"size":305,"leadingEdge":["IRF1","IL18BP","IL31RA","TAP2","TAP1","CD40","C4A","CD74","P2RX7","CD274","IL12RB1","ITK","SLAMF7","C4B","SERPING1","LAMP3","TBX21","ERAP2","C1QB","HLA-F","CEACAM1","HLA-DQB1","BTN3A2","HLA-B","BTN3A1","HLA-E","HLA-A","CTLA4","HLA-C","JAK2","CD7","RIPK2","TLR8","BTN3A3","C2","TNFSF13B","IL27","MCOLN2","ICAM1","CLEC6A","LILRB3","TNFSF18","CD80","RNF19B","B2M","C3","SLAMF6","CLEC10A","ZC3H12A","CTSS","JAK3","IRF7","RSAD2","LILRA1","C1S","C1RL","SLAMF1","C1R","HLA-G","GCNT3","RELB","BCL6","LYN","IL12A","LTA","TNFRSF14","PARP3","CTSL","IRF4","DENND1B","TNFAIP3","IL6","CLEC4D","LILRB4","NFKB2","TNF","EBI3","CD226","DUSP10","CD86","PTPRC","LILRB1","STAT3","NBN","TGFB1","SEMA4A","LILRA6","CCL19","CCR6","C1QC"]} {"pathway":"GO_DE_NOVO_PROTEIN_FOLDING","pval":0.00004,"padj":0.00798,"ES":0.9982,"NES":1.45028,"nMoreExtreme":2,"size":37,"leadingEdge":["CD74","HSPA5"]} {"pathway":"GO_SNRNA_TRANSCRIPTION","pval":0.00394,"padj":0.15223,"ES":0.91294,"NES":1.45004,"nMoreExtreme":292,"size":71,"leadingEdge":["ELL2","GTF2B","POLR2J"]} {"pathway":"GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_EXOGENOUS_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_I","pval":0.00396,"padj":0.15223,"ES":0.90567,"NES":1.44983,"nMoreExtreme":297,"size":76,"leadingEdge":["TAP2","PSME2","TAP1","PSMB9","HLA-F","HLA-B","PSME1","HLA-E","HLA-A","HLA-C","PSMB10","TAPBP","PSMB8","B2M","NCF1","HLA-G","PSMA4","PSMA2","IFI30","FCGR1A","PSMA5","NCF2","FCGR1B"]} {"pathway":"GO_DETERMINATION_OF_PANCREATIC_LEFT_RIGHT_ASYMMETRY","pval":0.06655,"padj":0.60375,"ES":0.98371,"NES":1.44929,"nMoreExtreme":3401,"size":3,"leadingEdge":["DNAAF1","NPHP3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MULTI_ORGANISM_PROCESS","pval":0.0017,"padj":0.0907,"ES":0.85226,"NES":1.44808,"nMoreExtreme":140,"size":142,"leadingEdge":["ACOD1","ISG20","STAT1","IFITM2","APOBEC3D","IFITM1","PML","CCL8","APOBEC3A","APOBEC3G","ZC3H12A","PARP10","CARD16","RSAD2","LILRA2","TRIM31","IFITM3","CCL5","IFIT5","LTA","OAS3","PLSCR1","TNFAIP3","APOBEC3F","TNF","MX1","CCL4","DHX58","IL2RA","TRIM21","ISG15","CCL3","TRIM25","MICB","ZFP36","OASL","IRF8","SIGLEC11","PROX1","ASTL"]} {"pathway":"GO_GOLGI_TO_PLASMA_MEMBRANE_TRANSPORT","pval":0.00235,"padj":0.10902,"ES":0.93433,"NES":1.44795,"nMoreExtreme":168,"size":58,"leadingEdge":["VAMP5","OPTN","AMN","ARF5"]} {"pathway":"GO_REGULATION_OF_CELLULAR_AMINO_ACID_METABOLIC_PROCESS","pval":0.00184,"padj":0.09582,"ES":0.94277,"NES":1.44725,"nMoreExtreme":130,"size":54,"leadingEdge":["PSME2","PSMB9","PSME1","PSMB10","PSMB8","PSMA4","PSMA2","PSMA5"]} {"pathway":"GO_T_CELL_PROLIFERATION","pval":0.00139,"padj":0.07928,"ES":0.84616,"NES":1.44617,"nMoreExtreme":116,"size":153,"leadingEdge":["IRF1","HLA-DPA1","IDO1","HLA-DMB","P2RX7","CD274","IL12RB1","PDCD1LG2","IL15","HLA-DPB1","BTN3A1","HLA-E","CTLA4","PSMB10","RIPK2","TNFSF13B","IL27","VCAM1","TNFSF18","CD80","JAK3","BTN2A2","HLA-G","CCL5","TNFRSF14","IL6","EBI3","CD86","PTPRC","LILRB1","TGFB1","CCDC88B","IL2RA","CCL19"]} {"pathway":"GO_RESPONSE_TO_CYTOKINE","pval":0.00001,"padj":0.00325,"ES":0.79027,"NES":1.44566,"nMoreExtreme":0,"size":988,"leadingEdge":["IRF1","GBP2","IL18BP","GBP5","HLA-DPA1","GBP4","IL15RA","IL31RA","UBD","PSME2","AIM2","CD40","GBP1","CD74","CIITA","CALCOCO2","SOCS1","CD274","HLA-DRA","SNX10","GCH1","IL12RB1","CXCL11","GBP3","PSMB9","CD38","IL15","IL32","LAMP3","HLA-DPB1","CXCL10","HLA-DRB1","NOD2","HLA-F","CEACAM1","HLA-DQB1","CCL13","HLA-DRB5","HLA-B","HGF","NLRC5","PSME1","IL3RA","HLA-E","ACOD1","CXCL9","ISG20","HLA-A","NMI","PADI2","STAT1","HLA-C","JAK2","PSMB10","NUB1","PIM1","HLA-DQB2","IFI27","RIPK2","TNFSF13B","STAT2","CCL7","IL27","ACSL1","PSMB8","IFI35","CAMK2D","HLA-DQA1","VCAM1","IFITM2","ICAM1","KLF4","MUC1","CCL15","ZBP1","IFITM1","FLT3LG","TNFSF18","CD80","XAF1","TRIM22","PML","CSF2RB","B2M","CCL8","CD300LF","MEFV","IFIT3","ZC3H12A","CCRL2","JAK3","CYLD","IFIT2","CASP4","STAP1","RAB20","IRF7","CARD16","IL12RB2","RSAD2","EDN1","VEGFC","IFIH1","GBP6","CISH","IL1RN","SBNO2","TRIM31","MT2A","IFITM3","HLA-G","MRAS","RELB","BCL6","CCL18","CCL5","IL12A","OAS2","PYHIN1","RUFY4","PARP14","TICAM2","CSF1","LTA","VRK2","TNFRSF14","TANK","OAS3","PARP9","IL7","SOD2","PLSCR1","IRF4","KYNU","TNFAIP3","CXCL16","CD70","BIRC3","MYD88","IL6","TLR3","IL2RG","LTB","NFKB2","TNF","STAT5A","TEX14","EBI3","PSMA4","PSMA2","PFKP","RBCK1","CUL1","CD86","CD47","IFI30","SMPD3","CCR5","CCL1","CXCL12","CYP27B1","PTPRC","CHI3L1","BSPRY","MX1","PTAFR","DDX58","CCL4","NR1H3","ACKR4","KLF6","F3","FCGR1A","SOCS3","CCL2","SH2B2","KMO","STAT3","PTPN2","MNDA","GCLC","RUNX1","SRC","TGFB1","CDC42EP2","OCSTAMP","ROBO1","IL2RA","CCL19","CCR6","STAT4","CXCL8","CDKN1A","PSMA5","TRIM21","ADAR","IKBKE","PTPN1","IL17C","NFKBIA","IFI6","MCL1","ISG15","OTUD4","LMNB1","CREBRF","PTGS2","RIPOR2","HAS2","SPPL2A","GAS6","CCL3","IRF5","CX3CL1","USP18","FOXC1","TRIM25","LIFR","GATA3","CASP1","NKX3-1","IRF2","NFE2L2","TNFRSF6B","IL33","FCGR1B","IRF9"]} {"pathway":"GO_SEQUESTERING_OF_IRON_ION","pval":0.07807,"padj":0.63581,"ES":0.98085,"NES":1.44507,"nMoreExtreme":3990,"size":3,"leadingEdge":["SRI","FTL"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_NLRP3_INFLAMMASOME_COMPLEX_ASSEMBLY","pval":0.08153,"padj":0.64487,"ES":0.97995,"NES":1.44374,"nMoreExtreme":4167,"size":3,"leadingEdge":["MEFV","SIRT2"]} {"pathway":"GO_MEIOTIC_DNA_DOUBLE_STRAND_BREAK_FORMATION","pval":0.08716,"padj":0.65493,"ES":0.97849,"NES":1.44159,"nMoreExtreme":4455,"size":3,"leadingEdge":["HORMAD1","MRE11"]} {"pathway":"GO_IMMUNE_EFFECTOR_PROCESS","pval":0.00001,"padj":0.00325,"ES":0.78802,"NES":1.44135,"nMoreExtreme":0,"size":969,"leadingEdge":["IRF1","IL31RA","HLA-DMB","AIM2","CD40","GBP1","C4A","CD74","P2RX7","IL12RB1","GBP3","SLAMF7","C4B","IL15","SERPING1","LAG3","TBX21","C1QB","CXCL10","NOD2","HLA-F","CEACAM1","ADGRE5","HLA-DQB1","BTN3A2","HLA-B","CFH","SELL","NLRC5","CFB","HLA-E","CXCL9","ISG20","HLA-A","PADI2","STAT1","HLA-C","SUCNR1","FGL2","IFI27","RIPK2","TLR8","BTN3A3","C2","STAT2","IL27","IFITM2","ICAM1","RTP4","APOBEC3D","LILRB3","IFITM1","ENPP4","TNFSF18","CD80","GSDMD","TSPAN32","TRIM22","PML","B2M","APOBEC3A","C3","SLAMF6","APOBEC3G","S100A13","IFIT3","ZC3H12A","CTSS","JAK3","IFIT2","IRF7","RSAD2","IFI44L","C1S","C1RL","IFIH1","SLAMF1","DTX3L","IGF2R","PMAIP1","MVP","LILRA2","SBNO2","DDX60","DYSF","C1R","IFITM3","HLA-G","SLAMF8","GCNT3","PTGER4","DYNLT1","RELB","BCL6","LYN","IL12A","OAS2","IFIT5","TNFAIP6","MMP25","TLR7","TICAM2","LTA","NR4A3","TNFRSF14","PARP3","OAS3","PARP9","PLSCR1","IRF4","DENND1B","TNFAIP3","ANXA3","BIRC3","APOBEC3F","CTSZ","IL6","TLR3","CLEC4D","CLEC4E","SEMA7A","NOTCH2","TNF","PSMA2","SERPINB9","CD226","DUSP10","CD86","CD47","RASGRP1","RAB24","ITGAL","PTPRC","CHI3L1","MX1","PTAFR","DDX58","LILRB1","FPR2","FCGR1A","STAT3","NBN","DHX58","PAK1","MNDA","SRC","TGFB1","SEMA4A","A2M","IL2RA","CCL19","CGAS","CCR6","C1QC","PSMA5","PRDX1","ADA2","CTSC","ADAR","GM2A","CREG1","HVCN1","IFI6","LIG4","ISG15","CCL3","IRF5","ACPP","TRIM25","IFIT1B","TCIM","SLC44A2","GATA3","IRF2","IL33","IRF9","DNAJC13","SERPINB1","ELMO2","CD53"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ODONTOGENESIS_OF_DENTIN_CONTAINING_TOOTH","pval":0.11251,"padj":0.69864,"ES":0.96619,"NES":1.44113,"nMoreExtreme":5653,"size":2,"leadingEdge":["CSF1","ODAPH"]} {"pathway":"GO_RNA_METHYLATION","pval":0.00565,"padj":0.19529,"ES":0.89739,"NES":1.44058,"nMoreExtreme":426,"size":78,"leadingEdge":["BMT2","TFB1M"]} {"pathway":"GO_RESPONSE_TO_STAUROSPORINE","pval":0.0943,"padj":0.66478,"ES":0.97675,"NES":1.43903,"nMoreExtreme":4820,"size":3,"leadingEdge":["CASP7","CASP6"]} {"pathway":"GO_REGULATION_OF_LEUKOCYTE_PROLIFERATION","pval":0.00116,"padj":0.07053,"ES":0.83196,"NES":1.43862,"nMoreExtreme":99,"size":180,"leadingEdge":["IRF1","HLA-DPA1","IDO1","HLA-DMB","CD40","CD74","CD274","IL12RB1","CD38","PDCD1LG2","IL15","HLA-DPB1","HLA-E","CTLA4","RIPK2","TNFSF13B","IL27","VCAM1","FLT3LG","TNFSF18","CD80","CCL8","JAK3","BTN2A2","HLA-G","BCL6","CCL5","LYN","IL12A","CSF1","TNFRSF14","IL7","TNFAIP3","IL6","FGF10","EBI3","CD86","PTPRC","LILRB1","MNDA","TGFB1","OCSTAMP","CCDC88B","IL2RA","CCL19"]} {"pathway":"GO_MULTI_ORGANISM_LOCALIZATION","pval":0.00634,"padj":0.20887,"ES":0.91053,"NES":1.43636,"nMoreExtreme":467,"size":67,"leadingEdge":["DYNLT1","BST2","NUP160"]} {"pathway":"GO_STEROL_TRANSPORT","pval":0.0063,"padj":0.2084,"ES":0.90564,"NES":1.43601,"nMoreExtreme":467,"size":70,"leadingEdge":["OSBPL6","SOAT1","GRAMD1B","TTC39B","LIPG","NR1H3","NFKBIA","CES1","NPC1"]} {"pathway":"GO_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE","pval":0.00683,"padj":0.21711,"ES":0.90034,"NES":1.43511,"nMoreExtreme":510,"size":73,"leadingEdge":["CD74","TBX21","NOD2","HLA-F","HLA-E","B2M","JAK3","RSAD2","HLA-G","BCL6","NR4A3","TNFRSF14","IL6","TLR3","SEMA7A","TNF","CD226","DDX58","LILRB1","TGFB1","GATA3","FCER1G","TLR4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_BASED_MOVEMENT","pval":0.12901,"padj":0.72213,"ES":0.96164,"NES":1.43434,"nMoreExtreme":6482,"size":2,"leadingEdge":["RNF207","TRPM4"]} {"pathway":"GO_REGULATION_OF_VOLTAGE_GATED_POTASSIUM_CHANNEL_ACTIVITY_INVOLVED_IN_VENTRICULAR_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL_REPOLARIZATION","pval":0.12901,"padj":0.72213,"ES":0.96164,"NES":1.43434,"nMoreExtreme":6482,"size":2,"leadingEdge":["RNF207","DLG1"]} {"pathway":"GO_ANTIGEN_PROCESSING_AND_PRESENTATION","pval":0.00091,"padj":0.05834,"ES":0.82247,"NES":1.43424,"nMoreExtreme":79,"size":205,"leadingEdge":["HLA-DPA1","HLA-DMA","TAP2","PSME2","TAP1","HLA-DMB","CD74","HLA-DOA","HLA-DRA","PSMB9","LAG3","HLA-DPB1","ERAP2","HLA-DRB1","NOD2","HLA-F","HLA-DQB1","HLA-DRB5","HLA-B","PSME1","HLA-E","HLA-A","HLA-C","PSMB10","HLA-DQB2","TAPBP","PSMB8","HLA-DOB","HLA-DQA1","ICAM1","B2M","CTSS","NCF1","TAPBPL","HLA-G","RELB","CTSL","MR1","PSMA4","PSMA2","IFI30","FCGR1A","CCL19","PSMA5"]} {"pathway":"GO_REGULATION_OF_IMMUNE_SYSTEM_PROCESS","pval":0.00001,"padj":0.00325,"ES":0.78246,"NES":1.4328,"nMoreExtreme":0,"size":1207,"leadingEdge":["IRF1","TIFA","GBP5","HLA-DPA1","IL31RA","IDO1","PSME2","HLA-DMB","AIM2","CD40","GBP1","C4A","CD74","HLA-DOA","P2RX7","SOCS1","CD274","LRRK2","HLA-DRA","IL12RB1","ITK","SLAMF7","PSMB9","C4B","CD38","PDCD1LG2","IL15","SERPING1","LAG3","PDE4B","HLA-DPB1","TBX21","C1QB","CXCL10","HLA-DRB1","NOD2","CLEC2B","HLA-F","CEACAM1","HLA-DQB1","BTN3A2","HLA-DRB5","HLA-B","CFH","SELL","NLRC5","PSME1","CFB","BTN3A1","HLA-E","ACOD1","BANK1","HLA-A","NMI","PADI2","STAT1","CTLA4","HLA-C","HCAR2","JAK2","PSMB10","TMEM176A","TRAFD1","HLA-DQB2","TMEM176B","RIPK2","TLR8","BTN3A3","C2","TNFSF13B","CCL7","IL27","PSMB8","HLA-DOB","HLA-DQA1","VCAM1","ICAM1","CLEC6A","MUC1","ZBP1","LILRB3","IFITM1","FLT3LG","TNFSF18","CD80","PDCD1","TSPAN32","B2M","CCL8","C3","SLAMF6","APOBEC3G","CLEC10A","CD300LF","TLR10","ZC3H12A","CTSS","JAK3","CYLD","P2RX4","STAP1","SCIN","IRF7","ICAM2","RSAD2","LILRA1","BTN2A2","C1S","EDN1","C1RL","VEGFC","IFIH1","DTX3L","LILRA2","TAPBPL","DDX60","DYSF","C1R","HLA-G","FYB1","SLAMF8","PTGER4","RELB","BCL6","CCL5","LYN","IL12A","PYHIN1","PARP14","TLR7","TICAM2","CSF1","LTA","NR4A3","TNFRSF14","TANK","PARP3","PARP9","IL7","CTSL","PLSCR1","CD83","IRF4","DENND1B","TNFAIP3","ICAM4","LILRA4","BIRC3","MYD88","APOBEC3F","IL6","TLR3","CLEC4D","CLEC4E","LILRB4","FGF10","EGR3","SEMA7A","NOTCH2","TNF","EBI3","PSMA4","PSMA2","SERPINB9","RBCK1","CD226","CUL1","DUSP10","CD86","GPR18","CD47","RASGRP1","PIK3AP1","CAMK1D","SMPD3","MOV10","CCL1","ITGAL","CXCL12","LCP2","PTPRC","PTAFR","DDX58","CCL4","NR1H3","LILRB1","FPR2","KLRC1","FCGR1A","SOCS3","CCL2","SH2B2","STAT3","P2RY12","PTPN2","ITGB7","DHX58","PAK1","MNDA","RUNX1","SRC","TGFB1","A2M","ICOS","OCSTAMP","CCDC88B","IL2RA","CCL19","CGAS","CCR6","WDFY1","C1QC","CXCL8","PSMA5","GP1BA","IKBKE","SLC7A2","PTPN1","NFKBIA","TREML4","ISG15","SH3RF1","OTUD4","RIPOR2","CD48","SPPL2A","GAS6","CCL3","CX3CL1","USP18","FOXC1","PRELID1","TCIM","GATA3","NFE2L2","IL33","PPARGC1B","FCGR1B","ELMO2","TREML2","DAPK2","ERAP1","PLCB1"]} {"pathway":"GO_NEUROTRANSMITTER_LOADING_INTO_SYNAPTIC_VESICLE","pval":0.1124,"padj":0.69864,"ES":0.97231,"NES":1.43249,"nMoreExtreme":5745,"size":3,"leadingEdge":["SLC18A1","SLC17A7"]} {"pathway":"GO_NIK_NF_KAPPAB_SIGNALING","pval":0.00248,"padj":0.11376,"ES":0.8399,"NES":1.43104,"nMoreExtreme":206,"size":147,"leadingEdge":["PSME2","PSMB9","NOD2","PSME1","PSMB10","PSMB8","ZC3H12A","CYLD","EDN1","RELB","LITAF","TLR7","BIRC3","TLR3","NFKB2","TNF","PSMA4","PSMA2","RBCK1","CUL1","CHI3L1","CCL19","PSMA5","PRDX1","IKBKE","NFKBIA","TCIM"]} {"pathway":"GO_ACTIVATION_OF_INNATE_IMMUNE_RESPONSE","pval":0.00038,"padj":0.03132,"ES":0.80805,"NES":1.42866,"nMoreExtreme":33,"size":264,"leadingEdge":["IRF1","TIFA","PSME2","AIM2","PSMB9","NOD2","PSME1","ACOD1","PSMB10","RIPK2","TLR8","PSMB8","CLEC6A","MUC1","CLEC10A","CD300LF","TLR10","CTSS","CYLD","IRF7","ICAM2","RSAD2","IFIH1","LILRA2","DDX60","RELB","LYN","PYHIN1","TLR7","TICAM2","TANK","CTSL","IRF4","TNFAIP3","LILRA4","BIRC3","MYD88","TLR3","CLEC4D","CLEC4E","PSMA4","PSMA2","CUL1","PIK3AP1","DDX58","NR1H3","DHX58","PAK1","MNDA","SRC","CGAS","WDFY1","PSMA5","IKBKE","NFKBIA","TREML4","OTUD4"]} {"pathway":"GO_REGULATION_OF_T_CELL_ACTIVATION","pval":0.00039,"padj":0.03152,"ES":0.80716,"NES":1.42709,"nMoreExtreme":34,"size":264,"leadingEdge":["IRF1","HLA-DPA1","IDO1","HLA-DMB","CD74","HLA-DOA","SOCS1","CD274","IL12RB1","PDCD1LG2","IL15","LAG3","HLA-DPB1","TBX21","NOD2","CEACAM1","HLA-E","CTLA4","RIPK2","TNFSF13B","IL27","VCAM1","TNFSF18","CD80","PDCD1","ZC3H12A","JAK3","CYLD","BTN2A2","HLA-G","BCL6","CCL5","LYN","IL12A","TNFRSF14","IL7","CD83","IRF4","IL6","LILRB4","EGR3","EBI3","DUSP10","CD86","CD47","RASGRP1","PTPRC","LILRB1","CCL2","PTPN2","PAK1","RUNX1","SRC","TGFB1","ICOS","CCDC88B","IL2RA","CCL19","CGAS"]} {"pathway":"GO_ENDOSOME_TO_LYSOSOME_TRANSPORT","pval":0.0043,"padj":0.16283,"ES":0.93614,"NES":1.42645,"nMoreExtreme":303,"size":51,"leadingEdge":["DTX3L","SNX16","SORT1","RILP","M6PR"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELL_ACTIVATION","pval":0.00259,"padj":0.11673,"ES":0.83395,"NES":1.42607,"nMoreExtreme":217,"size":154,"leadingEdge":["IRF1","IL31RA","IDO1","CD74","SOCS1","CD274","PDCD1LG2","LAG3","TBX21","HLA-F","CEACAM1","BANK1","CTLA4","CD80","TSPAN32","CD300LF","ZC3H12A","JAK3","BTN2A2","HLA-G","BCL6","LYN","TNFRSF14","PARP3","TNFAIP3","CD86","PTPRC","NR1H3","LILRB1","PTPN2","MNDA","GCLC","RUNX1","TGFB1","IL2RA","PDGFRA","RIPOR2","CX3CL1"]} {"pathway":"GO_LEUKOCYTE_CELL_CELL_ADHESION","pval":0.00031,"padj":0.02801,"ES":0.80467,"NES":1.42584,"nMoreExtreme":27,"size":275,"leadingEdge":["IRF1","HLA-DPA1","IDO1","HLA-DMB","CD74","SOCS1","CD274","IL12RB1","PDCD1LG2","IL15","LAG3","HLA-DPB1","TBX21","NOD2","CEACAM1","SELL","HLA-E","CTLA4","RIPK2","TNFSF13B","VCAM1","ICAM1","KLF4","CD80","PDCD1","ZC3H12A","JAK3","CYLD","BTN2A2","HLA-G","BCL6","CCL5","LYN","IL12A","NR4A3","TNFRSF14","IL7","CD83","IL6","LILRB4","EGR3","TNF","EBI3","DUSP10","CD86","CD47","RASGRP1","ITGAL","CXCL12","PTPRC","PTAFR","LILRB1","CCL2","PTPN2","ITGB7","PAK1","RUNX1","SRC","TGFB1","ICOS","CCDC88B","IL2RA","CCL19"]} {"pathway":"GO_HISTONE_DEACETYLATION","pval":0.00901,"padj":0.24715,"ES":0.90522,"NES":1.42541,"nMoreExtreme":662,"size":66,"leadingEdge":["LRRK2","CAMK2D","BCL6","TGFB1","HDAC4"]} {"pathway":"GO_MUSCLE_CELL_APOPTOTIC_PROCESS","pval":0.00597,"padj":0.20106,"ES":0.92858,"NES":1.42201,"nMoreExtreme":423,"size":53,"leadingEdge":["JAK2","AGT","CAMK2D","ZC3H12A","EDN1","IL12A","SOD2","CFLAR","NFE2L2"]} {"pathway":"GO_REGULATION_OF_STRIATED_MUSCLE_CONTRACTION","pval":0.01038,"padj":0.25928,"ES":0.9029,"NES":1.42177,"nMoreExtreme":763,"size":66,"leadingEdge":["PDE4B","KCNJ2","CAMK2D","SRI","ZC3H12A","P2RX4","ANK2","MYH7","RNF207","SLC8A1","CLIC2","MYBPH"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_RNA_METABOLIC_PROCESS","pval":0.00395,"padj":0.15223,"ES":0.94595,"NES":1.42094,"nMoreExtreme":274,"size":46,"leadingEdge":["ZC3H12A","TGFB1","PTBP1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS","pval":0.00006,"padj":0.01043,"ES":0.79292,"NES":1.42092,"nMoreExtreme":5,"size":354,"leadingEdge":["IRF1","IL31RA","IDO1","GBP1","CD74","HLA-DOA","SOCS1","CD274","PDCD1LG2","SERPING1","LAG3","TBX21","HLA-F","CEACAM1","NLRC5","HLA-E","ACOD1","BANK1","NMI","PADI2","CTLA4","TMEM176A","TRAFD1","TMEM176B","HLA-DOB","LILRB3","CD80","PDCD1","TSPAN32","CD300LF","ZC3H12A","JAK3","STAP1","BTN2A2","LILRA2","TAPBPL","HLA-G","SLAMF8","PTGER4","BCL6","LYN","PARP14","TICAM2","TNFRSF14","PARP3","IRF4","TNFAIP3","LILRA4","TLR3","LILRB4","TNF","SERPINB9","DUSP10","CD86","GPR18","CD47","CXCL12","PTPRC","NR1H3","LILRB1","CCL2","PTPN2","DHX58","MNDA","RUNX1","TGFB1","A2M","IL2RA","C1QC","NFKBIA","OTUD4","RIPOR2","CCL3","CX3CL1","NFE2L2","IL33"]} {"pathway":"GO_POSITIVE_REGULATION_OF_DOPAMINE_RECEPTOR_SIGNALING_PATHWAY","pval":0.00901,"padj":0.24715,"ES":0.99753,"NES":1.42052,"nMoreExtreme":468,"size":4,"leadingEdge":["LRRK2","VPS35"]} {"pathway":"GO_REGULATION_OF_PROTEIN_AUTOUBIQUITINATION","pval":0.00901,"padj":0.24715,"ES":0.99753,"NES":1.42052,"nMoreExtreme":468,"size":4,"leadingEdge":["LRRK2","SASH1"]} {"pathway":"GO_CELL_DIFFERENTIATION_INVOLVED_IN_PHENOTYPIC_SWITCHING","pval":0.15021,"padj":0.75097,"ES":0.96394,"NES":1.42016,"nMoreExtreme":7678,"size":3,"leadingEdge":["SOD2","FGF9"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION","pval":0.01027,"padj":0.25928,"ES":0.89074,"NES":1.41981,"nMoreExtreme":767,"size":73,"leadingEdge":["IRF1","STAT1","RIPK2","TLR8","ZBP1","IRF7","IFIH1","TLR7","MYD88","TLR3","NFKB2","DDX58","DHX58","CGAS","IRF5","FLOT1","TLR4"]} {"pathway":"GO_REGULATION_OF_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_CLEARANCE","pval":0.16719,"padj":0.77278,"ES":0.95063,"NES":1.41792,"nMoreExtreme":8401,"size":2,"leadingEdge":["LIPG","GPLD1"]} {"pathway":"GO_REGULATION_OF_ENDOTHELIAL_TUBE_MORPHOGENESIS","pval":0.02041,"padj":0.36159,"ES":0.995,"NES":1.41692,"nMoreExtreme":1061,"size":4,"leadingEdge":["CXCL10","FGF1"]} {"pathway":"GO_REGULATION_OF_SEROTONIN_SECRETION","pval":0.16974,"padj":0.77295,"ES":0.9499,"NES":1.41683,"nMoreExtreme":8529,"size":2,"leadingEdge":["LILRB1","HTR1B"]} {"pathway":"GO_REGULATION_OF_MEMBRANE_REPOLARIZATION_DURING_VENTRICULAR_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL","pval":0.16038,"padj":0.76421,"ES":0.96164,"NES":1.41677,"nMoreExtreme":8198,"size":3,"leadingEdge":["RNF207","DLG1"]} {"pathway":"GO_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING","pval":0.00074,"padj":0.05252,"ES":0.80461,"NES":1.41643,"nMoreExtreme":65,"size":243,"leadingEdge":["TIFA","APOL3","UBD","CD40","CD74","NOD2","TNFSF10","SECTM1","OPTN","STAT1","RIPK2","TLR8","CLEC6A","TGM2","TRIM22","S100A13","ZC3H12A","CARD16","IL1RN","RELB","LITAF","TIFAB","IFIT5","TLR7","TICAM2","TANK","TNFAIP3","BIRC3","MYD88","CASP10","TLR3","TNF","RBCK1","RHOH","CCL19","IKBKE","NFKBIA","LPAR1","CX3CL1","TRIM25","CFLAR","SLC44A2","CASP1"]} {"pathway":"GO_POST_GOLGI_VESICLE_MEDIATED_TRANSPORT","pval":0.00757,"padj":0.22825,"ES":0.85867,"NES":1.41629,"nMoreExtreme":595,"size":101,"leadingEdge":["VAMP5","OPTN","IGF2R","DOP1A","SORT1","AMN","AP1AR"]} {"pathway":"GO_REGULATION_OF_AUTOPHAGY_OF_MITOCHONDRION","pval":0.00255,"padj":0.11542,"ES":0.96597,"NES":1.41564,"nMoreExtreme":172,"size":39,"leadingEdge":["ATP13A2","OPTN","CLEC16A"]} {"pathway":"GO_POSITIVE_REGULATION_OF_METALLOENDOPEPTIDASE_ACTIVITY","pval":0.17631,"padj":0.77529,"ES":0.94799,"NES":1.41398,"nMoreExtreme":8859,"size":2,"leadingEdge":["STAT3","MBP"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELL_ACTIVATION","pval":0.00057,"padj":0.04198,"ES":0.79836,"NES":1.41372,"nMoreExtreme":51,"size":272,"leadingEdge":["HLA-DPA1","HLA-DMB","CD40","CD74","SOCS1","CD274","LRRK2","IL12RB1","CD38","PDCD1LG2","IL15","HLA-DPB1","TBX21","NOD2","HLA-F","PLEK","HLA-E","CTLA4","JAK2","RIPK2","TNFSF13B","VCAM1","FLT3LG","CD80","PDCD1","JAK3","CYLD","STAP1","BTN2A2","LILRA2","HLA-G","BCL6","CCL5","LYN","IL12A","NR4A3","TNFRSF14","IL7","CD83","IL6","CLEC4D","LILRB4","FGF10","EGR3","EBI3","CD226","DUSP10","CD86","CD47","RASGRP1","PTPRC","PTAFR","LILRB1","CCL2","PAK1","RUNX1","SRC","TGFB1","ICOS","CCDC88B","IL2RA","CCL19"]} {"pathway":"GO_REGULATION_OF_INTERLEUKIN_6_MEDIATED_SIGNALING_PATHWAY","pval":0.17856,"padj":0.77529,"ES":0.94737,"NES":1.41306,"nMoreExtreme":8972,"size":2,"leadingEdge":["PTPN2","GFI1"]} {"pathway":"GO_RUFFLE_ORGANIZATION","pval":0.00583,"padj":0.19815,"ES":0.9376,"NES":1.41272,"nMoreExtreme":406,"size":47,"leadingEdge":["SNX10","PLEK","ICAM1","STAP1","P2RY12","COBL"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_VIRAL_PROCESS","pval":0.01038,"padj":0.25928,"ES":0.87303,"NES":1.4126,"nMoreExtreme":792,"size":84,"leadingEdge":["ISG20","STAT1","IFITM2","APOBEC3D","IFITM1","PML","CCL8","APOBEC3A","APOBEC3G","ZC3H12A","PARP10","RSAD2","TRIM31","IFITM3","CCL5","IFIT5","OAS3","PLSCR1","APOBEC3F","TNF","MX1","CCL4","TRIM21","ISG15","CCL3","TRIM25","ZFP36","OASL"]} {"pathway":"GO_RHOMBOMERE_DEVELOPMENT","pval":0.03614,"padj":0.48681,"ES":0.99163,"NES":1.41212,"nMoreExtreme":1880,"size":4,"leadingEdge":["EGR2","HOXB3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_LEUKOCYTE_CELL_CELL_ADHESION","pval":0.00267,"padj":0.11935,"ES":0.81592,"NES":1.4118,"nMoreExtreme":229,"size":182,"leadingEdge":["HLA-DPA1","HLA-DMB","CD74","SOCS1","CD274","IL12RB1","PDCD1LG2","IL15","HLA-DPB1","NOD2","HLA-E","CTLA4","RIPK2","TNFSF13B","VCAM1","ICAM1","CD80","PDCD1","JAK3","CYLD","BTN2A2","HLA-G","BCL6","CCL5","LYN","IL12A","NR4A3","TNFRSF14","IL7","CD83","IL6","LILRB4","EGR3","TNF","EBI3","DUSP10","CD86","CD47","RASGRP1","PTPRC","PTAFR","LILRB1","CCL2","PAK1","RUNX1","SRC","TGFB1","ICOS","CCDC88B","IL2RA","CCL19"]} {"pathway":"GO_REGULATION_OF_SUPEROXIDE_DISMUTASE_ACTIVITY","pval":0.17664,"padj":0.77529,"ES":0.95782,"NES":1.41114,"nMoreExtreme":9029,"size":3,"leadingEdge":["TNF","PARK7"]} {"pathway":"GO_METANEPHRIC_MESENCHYMAL_CELL_DIFFERENTIATION","pval":0.04014,"padj":0.51243,"ES":0.99073,"NES":1.41084,"nMoreExtreme":2088,"size":4,"leadingEdge":["STAT1","TCF21"]} {"pathway":"GO_RESPONSE_TO_NUTRIENT","pval":0.00309,"padj":0.13099,"ES":0.81768,"NES":1.4103,"nMoreExtreme":263,"size":174,"leadingEdge":["CD40","P2RX7","IL15","CXCL10","NOD2","SELL","STAT1","PIM1","C2","ACSL1","VCAM1","CYP1A1","P2RX4","LTA","KYNU","SLC8A1","NCOA1","ASCL1","CYP27B1","LIPG","P2RY12","GCLC","TGFB1","P2RY2","PTGS2","GAS6","TRIM25"]} {"pathway":"GO_CORNEA_DEVELOPMENT_IN_CAMERA_TYPE_EYE","pval":0.04194,"padj":0.51988,"ES":0.99034,"NES":1.41028,"nMoreExtreme":2182,"size":4,"leadingEdge":["LIMK2","WNT2B"]} {"pathway":"GO_POSITIVE_REGULATION_OF_THE_FORCE_OF_HEART_CONTRACTION","pval":0.18133,"padj":0.77573,"ES":0.95675,"NES":1.40957,"nMoreExtreme":9269,"size":3,"leadingEdge":["SLC8A1","NOS1"]} {"pathway":"GO_CELLULAR_AMINO_ACID_METABOLIC_PROCESS","pval":0.00117,"padj":0.07053,"ES":0.80368,"NES":1.40951,"nMoreExtreme":103,"size":227,"leadingEdge":["IDO1","PSME2","PSMB9","PSME1","IDO2","PSMB10","PSMB8","PPA1","CTNS","GGT5","GLUL","KYNU","SDSL","PSMA4","PSMA2","KMO","GCLC","PSMA5","SLC7A2","ASNS","GLS","SEPHS2","ASS1","MTHFR","CBSL","SDS"]} {"pathway":"GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS","pval":0.01386,"padj":0.30637,"ES":0.89344,"NES":1.40941,"nMoreExtreme":1021,"size":67,"leadingEdge":["AIM2","IL12RB1","IL15","STAT1","IL27","TSPAN32","APOBEC3G","ZC3H12A","DTX3L","DDX60","PARP9","TNFAIP3","BIRC3","APOBEC3F","DDX58","LILRB1","DHX58","IL2RA","CGAS"]} {"pathway":"GO_RENAL_CONTROL_OF_PERIPHERAL_VASCULAR_RESISTANCE_INVOLVED_IN_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE","pval":0.04611,"padj":0.53818,"ES":0.98938,"NES":1.40892,"nMoreExtreme":2399,"size":4,"leadingEdge":["AGT","RHOA"]} {"pathway":"GO_VESICLE_MEDIATED_TRANSPORT_TO_THE_PLASMA_MEMBRANE","pval":0.01075,"padj":0.26757,"ES":0.86621,"NES":1.40803,"nMoreExtreme":826,"size":88,"leadingEdge":["VAMP5","OPTN","AMN","STX3","ARF5"]} {"pathway":"GO_RESPONSE_TO_TUMOR_NECROSIS_FACTOR","pval":0.00083,"padj":0.05489,"ES":0.79708,"NES":1.40799,"nMoreExtreme":74,"size":260,"leadingEdge":["GBP2","IL18BP","UBD","PSME2","AIM2","CD40","GBP1","GCH1","GBP3","PSMB9","CCL13","PSME1","ACOD1","STAT1","JAK2","PSMB10","NUB1","TNFSF13B","CCL7","PSMB8","VCAM1","ICAM1","CCL15","TNFSF18","CCL8","ZC3H12A","CYLD","CASP4","CARD16","EDN1","CCL18","CCL5","LTA","TNFRSF14","TANK","TNFAIP3","CXCL16","CD70","BIRC3","LTB","TNF","PSMA4","PSMA2","RBCK1","SMPD3","CCL1","CHI3L1","CCL4","CCL2","PTPN2","OCSTAMP","CCL19","CXCL8","PSMA5","NFKBIA","PTGS2","HAS2","SPPL2A","GAS6","CCL3","CX3CL1","GATA3","CASP1","NKX3-1","NFE2L2","TNFRSF6B"]} {"pathway":"GO_POSITIVE_REGULATION_OF_FLAGELLATED_SPERM_MOTILITY","pval":0.19141,"padj":0.79001,"ES":0.94378,"NES":1.4077,"nMoreExtreme":9618,"size":2,"leadingEdge":["CCR6","CFAP69"]} {"pathway":"GO_REGULATION_OF_MULTI_ORGANISM_PROCESS","pval":0.0002,"padj":0.02173,"ES":0.7874,"NES":1.40763,"nMoreExtreme":18,"size":335,"leadingEdge":["AIM2","CD74","P2RX7","IL12RB1","IL15","LAMP3","ACOD1","ISG20","OPTN","STAT1","IFI27","RIPK2","IL27","IFITM2","BCL2L11","APOBEC3D","IFITM1","TSPAN32","PML","CCL8","APOBEC3A","APOBEC3G","ZC3H12A","PARP10","CARD16","RSAD2","DTX3L","LILRA2","TRIM31","DDX60","IFITM3","CHMP4C","DYNLT1","CCL5","IFIT5","LTA","OAS3","PARP9","PLSCR1","TNFAIP3","BIRC3","APOBEC3F","TNF","HPN","MX1","PTAFR","DDX58","CCL4","LILRB1","DHX58","IL2RA","CGAS","CXCL8","TRIM21","ADAR","ISG15","CCL3","CX3CL1","TRIM25","SPINK1","PLCB1","MICB","ZFP36","STOM","OASL"]} {"pathway":"GO_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_REGENERATION","pval":0.1939,"padj":0.79001,"ES":0.94299,"NES":1.40653,"nMoreExtreme":9743,"size":2,"leadingEdge":["CDKN1A","CDKN1B"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_VIRAL_GENOME_REPLICATION","pval":0.0119,"padj":0.27955,"ES":0.91841,"NES":1.40644,"nMoreExtreme":844,"size":53,"leadingEdge":["ISG20","IFITM2","APOBEC3D","IFITM1","CCL8","APOBEC3A","APOBEC3G","ZC3H12A","PARP10","RSAD2","IFITM3","CCL5","IFIT5","OAS3","PLSCR1","APOBEC3F","TNF","MX1","ISG15"]} {"pathway":"GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION","pval":0.01483,"padj":0.31281,"ES":0.90752,"NES":1.4064,"nMoreExtreme":1067,"size":58,"leadingEdge":["PDE4B","KCNJ2","CAMK2D","SRI","ZC3H12A","P2RX4","ANK2","RNF207","SLC8A1","CLIC2"]} {"pathway":"GO_REGULATION_OF_LYMPHOCYTE_ACTIVATION","pval":0.00019,"padj":0.02104,"ES":0.78492,"NES":1.40616,"nMoreExtreme":17,"size":351,"leadingEdge":["IRF1","HLA-DPA1","IDO1","HLA-DMB","CD40","CD74","HLA-DOA","SOCS1","CD274","IL12RB1","CD38","PDCD1LG2","IL15","LAG3","HLA-DPB1","TBX21","NOD2","HLA-F","CEACAM1","HLA-E","BANK1","CTLA4","RIPK2","TNFSF13B","IL27","VCAM1","FLT3LG","TNFSF18","CD80","PDCD1","ZC3H12A","JAK3","CYLD","BTN2A2","HLA-G","SLAMF8","BCL6","CCL5","LYN","IL12A","TNFRSF14","PARP3","IL7","CD83","IRF4","TNFAIP3","IL6","LILRB4","FGF10","EGR3","EBI3","DUSP10","CD86","CD47","RASGRP1","PTPRC","LILRB1","CCL2","PTPN2","PAK1","MNDA","RUNX1","SRC","TGFB1","ICOS","CCDC88B","IL2RA","CCL19","CGAS"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELL_CELL_ADHESION","pval":0.00194,"padj":0.0971,"ES":0.80545,"NES":1.40595,"nMoreExtreme":169,"size":209,"leadingEdge":["HLA-DPA1","HLA-DMB","CD74","SOCS1","CD274","IL12RB1","PDCD1LG2","IL15","HLA-DPB1","NOD2","HLA-E","CTLA4","RIPK2","TNFSF13B","VCAM1","ICAM1","CD80","PDCD1","JAK3","CYLD","BTN2A2","HLA-G","BCL6","CCL5","LYN","IL12A","NR4A3","TNFRSF14","IL7","PTPRU","CD83","IL6","LILRB4","EGR3","TNF","EBI3","DUSP10","CD86","CD47","RASGRP1","PTPRC","PTAFR","LILRB1","CCL2","PAK1","PODXL","RUNX1","SRC","TGFB1","ICOS","CCDC88B","IL2RA","CCL19"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS","pval":0.01038,"padj":0.25928,"ES":0.85498,"NES":1.4056,"nMoreExtreme":812,"size":98,"leadingEdge":["SERPING1","TBX21","HLA-F","CEACAM1","HLA-E","ZC3H12A","JAK3","HLA-G","SLAMF8","BCL6","PARP3","TNF","SERPINB9","DUSP10","CD47","PTPRC","LILRB1","DHX58","TGFB1","A2M","IL2RA","IL33","MICB","HLX","IFNL1"]} {"pathway":"GO_REGULATION_OF_CELL_CELL_ADHESION","pval":0.00028,"padj":0.02706,"ES":0.78653,"NES":1.40484,"nMoreExtreme":25,"size":326,"leadingEdge":["IRF1","HLA-DPA1","IDO1","HLA-DMB","CD74","SOCS1","CD274","IL12RB1","PDCD1LG2","IL15","LAG3","HLA-DPB1","TBX21","NOD2","CEACAM1","HLA-E","CTLA4","JAK2","RIPK2","TNFSF13B","VCAM1","ICAM1","MDGA1","KLF4","CD80","PDCD1","ZC3H12A","JAK3","CYLD","BTN2A2","IL1RN","HLA-G","BCL6","CCL5","LYN","IL12A","NR4A3","TNFRSF14","IL7","PTPRU","CD83","IL6","LILRB4","EGR3","TNF","EBI3","DUSP10","CD86","CD47","RASGRP1","CXCL12","PTPRC","PTAFR","LILRB1","CCL2","PTPN2","PAK1","PODXL","RUNX1","SRC","TGFB1","ICOS","CCDC88B","IL2RA","CCL19"]} {"pathway":"GO_REGULATION_OF_CELL_ACTIVATION","pval":0.00007,"padj":0.01098,"ES":0.77747,"NES":1.40431,"nMoreExtreme":6,"size":449,"leadingEdge":["IRF1","HLA-DPA1","IL31RA","IDO1","HLA-DMB","CD40","CD74","HLA-DOA","SOCS1","CD274","LRRK2","IL12RB1","CD38","PDCD1LG2","IL15","LAG3","HLA-DPB1","TBX21","NOD2","HLA-F","CEACAM1","PLEK","HLA-E","BANK1","CTLA4","JAK2","RIPK2","TNFSF13B","IL27","VCAM1","FLT3LG","TNFSF18","CD80","PDCD1","TSPAN32","CD300LF","ZC3H12A","JAK3","CYLD","STAP1","BTN2A2","LILRA2","HLA-G","SLAMF8","BCL6","CCL5","LYN","IL12A","NR4A3","TNFRSF14","PARP3","IL7","PLSCR1","CD83","IRF4","TNFAIP3","IL6","CLEC4D","LILRB4","FGF10","EGR3","TNF","EBI3","CD226","DUSP10","CD86","CD47","RASGRP1","PTPRC","PTAFR","NR1H3","LILRB1","CCL2","PTPN2","PAK1","MNDA","GCLC","RUNX1","SRC","TGFB1","ICOS","CCDC88B","IL2RA","CCL19","CGAS","PDGFRA","SLC7A2","SH3RF1","RIPOR2","GAS6","CCL3","CX3CL1","PRELID1","GATA3","IL33"]} {"pathway":"GO_PRIMARY_AMINO_COMPOUND_BIOSYNTHETIC_PROCESS","pval":0.19911,"padj":0.79183,"ES":0.95299,"NES":1.40402,"nMoreExtreme":10178,"size":3,"leadingEdge":["AZIN2","AGMAT"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CHEMOKINE_C_C_MOTIF_LIGAND_5_PRODUCTION","pval":0.06335,"padj":0.59468,"ES":0.98556,"NES":1.40348,"nMoreExtreme":3296,"size":4,"leadingEdge":["MCOLN2","MAVS"]} {"pathway":"GO_REGULATION_OF_RELAXATION_OF_CARDIAC_MUSCLE","pval":0.06383,"padj":0.59614,"ES":0.98545,"NES":1.40332,"nMoreExtreme":3321,"size":4,"leadingEdge":["PDE4B","CAMK2D","PDE4D"]} {"pathway":"GO_GLUTAMINE_FAMILY_AMINO_ACID_METABOLIC_PROCESS","pval":0.01474,"padj":0.31281,"ES":0.91189,"NES":1.40302,"nMoreExtreme":1051,"size":55,"leadingEdge":["GGT5","GLUL","GCLC","ASNS","GLS","ASS1","NOS2"]} {"pathway":"GO_REGULATION_OF_THYROID_HORMONE_MEDIATED_SIGNALING_PATHWAY","pval":0.20293,"padj":0.79569,"ES":0.95214,"NES":1.40278,"nMoreExtreme":10373,"size":3,"leadingEdge":["NCOA1","THRA"]} {"pathway":"GO_OMEGA_HYDROXYLASE_P450_PATHWAY","pval":0.06544,"padj":0.60364,"ES":0.98506,"NES":1.40276,"nMoreExtreme":3405,"size":4,"leadingEdge":["CYP1A1","CYP1B1"]} {"pathway":"GO_CALCIUM_ACTIVATED_PHOSPHOLIPID_SCRAMBLING","pval":0.06571,"padj":0.60375,"ES":0.98505,"NES":1.40276,"nMoreExtreme":3419,"size":4,"leadingEdge":["ANO4","ANO9"]} {"pathway":"GO_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY","pval":0.01164,"padj":0.27743,"ES":0.92322,"NES":1.4025,"nMoreExtreme":818,"size":50,"leadingEdge":["GBP1","CEACAM1","CYLD","STAP1","BTN2A2","LYN","LILRB4","CD226","PTPRC","PTPN2","RUNX1","NFAM1","PAX5"]} {"pathway":"GO_POSITIVE_REGULATION_OF_DOPAMINE_SECRETION","pval":0.20582,"padj":0.79637,"ES":0.95147,"NES":1.40179,"nMoreExtreme":10521,"size":3,"leadingEdge":["CXCL12","PINK1"]} {"pathway":"GO_FAT_SOLUBLE_VITAMIN_CATABOLIC_PROCESS","pval":0.20611,"padj":0.79637,"ES":0.95136,"NES":1.40162,"nMoreExtreme":10536,"size":3,"leadingEdge":["CYP27B1","CYP26B1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE_MEDIATED_BY_CIRCULATING_IMMUNOGLOBULIN","pval":0.20717,"padj":0.79637,"ES":0.95113,"NES":1.40129,"nMoreExtreme":10590,"size":3,"leadingEdge":["LTA","TNF","PTPRC"]} {"pathway":"GO_CYTOKINE_PRODUCTION","pval":0.00001,"padj":0.00325,"ES":0.76997,"NES":1.40114,"nMoreExtreme":0,"size":625,"leadingEdge":["IRF1","GBP5","HLA-DPA1","IL31RA","IDO1","AIM2","CD40","GBP1","CD74","P2RX7","SOCS1","CD274","LRRK2","IL12RB1","ITK","PDCD1LG2","IL15","LAG3","PDE4B","HLA-DPB1","TBX21","NOD2","HLA-F","CEACAM1","BTN3A2","CLEC9A","HGF","NLRC5","BTN3A1","HLA-E","ACOD1","BANK1","NMI","STAT1","JAK2","SUCNR1","AGT","RIPK2","TLR8","UBE2L6","IL27","MCOLN2","KLF4","CLEC6A","ZBP1","CD80","GSDMD","PML","B2M","C3","SLAMF6","MEFV","S100A13","TLR10","ZC3H12A","JAK3","CYLD","CARD17","IRF7","CARD16","IL12RB2","RSAD2","BTN2A2","IFIH1","SLAMF1","LILRA2","IL1RN","DDX60","DYSF","HLA-G","PTGER4","RELB","BCL6","LITAF","LYN","IL12A","TLR7","LTA","NR4A3","TNFRSF14","IL7","CD83","IRF4","DENND1B","TNFAIP3","LILRA4","BIRC3","MYD88","IL6","TLR3","CLEC4E","LTB","JPH4","SEMA7A","NFKB2","TNF","MR1","EBI3","CD226","CD86","GPR18","CD47","RASGRP1","CCL1","LCP2","PTPRC","CHI3L1","PTAFR","DDX58","LILRB1","STAT3","DHX58","RUNX1","SRC","TGFB1","CCDC88B","CCL19","CGAS","AKIRIN2","TRIM21","IKBKE","ISG15","PTGS2","GAS6","CCL3","IRF5","CX3CL1","TRIM25","GATA3","CASP1","IL33"]} {"pathway":"GO_MEMBRANE_RAFT_DISTRIBUTION","pval":0.20756,"padj":0.79637,"ES":0.95102,"NES":1.40113,"nMoreExtreme":10610,"size":3,"leadingEdge":["PTPRC","DOCK2"]} {"pathway":"GO_DETERMINATION_OF_LIVER_LEFT_RIGHT_ASYMMETRY","pval":0.07178,"padj":0.62112,"ES":0.98371,"NES":1.40084,"nMoreExtreme":3735,"size":4,"leadingEdge":["DNAAF1","NPHP3"]} {"pathway":"GO_ACTIVATION_OF_MAPKK_ACTIVITY","pval":0.0135,"padj":0.3004,"ES":0.91926,"NES":1.40073,"nMoreExtreme":953,"size":51,"leadingEdge":["LRRK2","JAK2","RIPK2","NRK","GADD45B","MAP3K8","NGF","EIF2AK2","MLKL"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NEUTROPHIL_ACTIVATION","pval":0.21056,"padj":0.79831,"ES":0.9504,"NES":1.40021,"nMoreExtreme":10763,"size":3,"leadingEdge":["PTAFR","ITGB2"]} {"pathway":"GO_REGULATION_OF_POSTTRANSCRIPTIONAL_GENE_SILENCING","pval":0.01476,"padj":0.31281,"ES":0.86951,"NES":1.39987,"nMoreExtreme":1119,"size":80,"leadingEdge":["ZC3H12A","STAT3","TRIM71","TGFB1","LIN28A","ZFP36","POLR2J"]} {"pathway":"GO_RESPONSE_TO_CORTICOTROPIN_RELEASING_HORMONE","pval":0.21173,"padj":0.79872,"ES":0.95006,"NES":1.39972,"nMoreExtreme":10823,"size":3,"leadingEdge":["NR4A3","NR4A2","NR4A1"]} {"pathway":"GO_COLLAGEN_FIBRIL_ORGANIZATION","pval":0.00976,"padj":0.25395,"ES":0.93176,"NES":1.39962,"nMoreExtreme":678,"size":46,"leadingEdge":["COMP","FOXC1","COL11A1"]} {"pathway":"GO_LYSOSOME_LOCALIZATION","pval":0.01812,"padj":0.35354,"ES":0.90309,"NES":1.39954,"nMoreExtreme":1304,"size":58,"leadingEdge":["S100A13","LYN","NR4A3","RASGRP1","FCER1G","CD84","MAP6","FGR"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_OSTEOCLAST_DEVELOPMENT","pval":0.21251,"padj":0.79961,"ES":0.9499,"NES":1.39947,"nMoreExtreme":10863,"size":3,"leadingEdge":["LILRB1","FBXW7"]} {"pathway":"GO_FC_RECEPTOR_SIGNALING_PATHWAY","pval":0.00441,"padj":0.1652,"ES":0.812,"NES":1.3991,"nMoreExtreme":375,"size":171,"leadingEdge":["PSME2","ITK","PSMB9","PSME1","PSMB10","PSMB8","LYN","NR4A3","LILRA4","CLEC4D","CLEC4E","PSMA4","PSMA2","CUL1","CD47","LCP2","PTPRC","FCGR1A","PAK1","SRC","PSMA5","FCGR1B","ELMO2","FCER1G"]} {"pathway":"GO_PROTEIN_REFOLDING","pval":0.00218,"padj":0.10317,"ES":0.98053,"NES":1.39902,"nMoreExtreme":143,"size":33,"leadingEdge":["B2M","HSPA5"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_APOPTOTIC_PROCESS_IN_BONE_MARROW_CELL","pval":0.07741,"padj":0.63581,"ES":0.98231,"NES":1.39884,"nMoreExtreme":4028,"size":4,"leadingEdge":["FLT3LG","FGFR2"]} {"pathway":"GO_TRANSPORT_OF_VIRUS","pval":0.01705,"padj":0.33929,"ES":0.91055,"NES":1.39779,"nMoreExtreme":1213,"size":54,"leadingEdge":["DYNLT1","BST2","NUP160"]} {"pathway":"GO_REGULATION_OF_VIRAL_TRANSCRIPTION","pval":0.01837,"padj":0.35375,"ES":0.89288,"NES":1.39755,"nMoreExtreme":1341,"size":63,"leadingEdge":["TRIM31","IFITM3","CCL5","HPN","CCL4","TRIM21","CCL3","ZFP36","GTF2B","POLR2J"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION","pval":0.00023,"padj":0.02413,"ES":0.77741,"NES":1.39571,"nMoreExtreme":21,"size":372,"leadingEdge":["IRF1","GBP5","HLA-DPA1","IDO1","AIM2","CD40","CD74","P2RX7","CD274","LRRK2","IL12RB1","IL15","PDE4B","HLA-DPB1","NOD2","HLA-F","CLEC9A","HGF","HLA-E","STAT1","JAK2","AGT","RIPK2","TLR8","IL27","MCOLN2","CLEC6A","ZBP1","CD80","GSDMD","B2M","C3","SLAMF6","IRF7","IL12RB2","RSAD2","IFIH1","LILRA2","IL1RN","DDX60","HLA-G","PTGER4","IL12A","TLR7","LTA","NR4A3","TNFRSF14","IL7","CD83","IRF4","BIRC3","MYD88","IL6","TLR3","CLEC4E","LTB","SEMA7A","NFKB2","TNF","EBI3","CD226","CD86","RASGRP1","CCL1","PTPRC","PTAFR","DDX58","LILRB1","STAT3","DHX58","RUNX1","SRC","TGFB1","CCDC88B","CCL19","CGAS","AKIRIN2","PTGS2","CCL3","IRF5","CX3CL1","GATA3","CASP1","IL33"]} {"pathway":"GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_IN_RESPONSE_TO_STRESS","pval":0.01033,"padj":0.25928,"ES":0.83737,"NES":1.39474,"nMoreExtreme":826,"size":112,"leadingEdge":["PSME2","PSMB9","PSME1","ATF3","PSMB10","PSMB8","MUC1","BACH1","PSMA4","PSMA2","PSMA5","TCIM","NFE2L2"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_ETHER","pval":0.09034,"padj":0.66096,"ES":0.97938,"NES":1.39468,"nMoreExtreme":4701,"size":4,"leadingEdge":["ZC3H12A","NFATC4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELL_CELL_ADHESION_MEDIATED_BY_INTEGRIN","pval":0.22775,"padj":0.81476,"ES":0.94653,"NES":1.3945,"nMoreExtreme":11642,"size":3,"leadingEdge":["CCL5","PODXL","PIEZO1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELL_ADHESION","pval":0.00214,"padj":0.10284,"ES":0.79517,"NES":1.39409,"nMoreExtreme":189,"size":225,"leadingEdge":["IRF1","IDO1","GBP1","CD74","SOCS1","CD274","PDCD1LG2","LAG3","TBX21","CEACAM1","CTLA4","JAK2","KLF4","MUC1","CD80","ZC3H12A","JAK3","BTN2A2","MIR503","FAM107A","IL1RN","HLA-G","BCL6","TNFRSF14","RND1","CD86","CXCL12","PTPRC","LILRB1","PTPN2","PODXL","RUNX1","SRC","TGFB1","IL2RA","RIPOR2","CX3CL1","AP1AR","SEMA4D"]} {"pathway":"GO_RESPONSE_TO_INTERLEUKIN_12","pval":0.01335,"padj":0.29795,"ES":0.92511,"NES":1.39389,"nMoreExtreme":931,"size":47,"leadingEdge":["PSME2","IL12RB1","JAK2","RIPK2","IL12RB2","IL12A","SOD2","CD47","STAT4","LMNB1","PLCB1"]} {"pathway":"GO_SENSORY_PERCEPTION_OF_TOUCH","pval":0.09497,"padj":0.6659,"ES":0.97837,"NES":1.39324,"nMoreExtreme":4942,"size":4,"leadingEdge":["P2RX4","RAB3A"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CAMP_DEPENDENT_PROTEIN_KINASE_ACTIVITY","pval":0.09559,"padj":0.66591,"ES":0.9782,"NES":1.393,"nMoreExtreme":4974,"size":4,"leadingEdge":["RAPGEF2","ATP2B4"]} {"pathway":"GO_LYMPHOCYTE_MEDIATED_IMMUNITY","pval":0.00377,"padj":0.14958,"ES":0.80211,"NES":1.39275,"nMoreExtreme":326,"size":192,"leadingEdge":["IL31RA","CD40","C4A","CD74","P2RX7","IL12RB1","SLAMF7","C4B","SERPING1","LAG3","TBX21","C1QB","HLA-F","CEACAM1","HLA-DQB1","BTN3A2","HLA-B","HLA-E","HLA-A","HLA-C","TLR8","BTN3A3","C2","ICAM1","B2M","C3","SLAMF6","IRF7","RSAD2","C1S","C1RL","C1R","HLA-G","GCNT3","BCL6","IL12A","LTA","PARP3","DENND1B","IL6","TNF","SERPINB9","CD226","RASGRP1","PTPRC","LILRB1","NBN","TGFB1","CCR6","C1QC","PRDX1","CTSC","LIG4"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_RUFFLE_ASSEMBLY","pval":0.0978,"padj":0.66591,"ES":0.9777,"NES":1.39228,"nMoreExtreme":5089,"size":4,"leadingEdge":["STAP1","PFN2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_ACTIVATION","pval":0.00207,"padj":0.10082,"ES":0.79365,"NES":1.39192,"nMoreExtreme":183,"size":227,"leadingEdge":["HLA-DPA1","HLA-DMB","CD40","CD74","SOCS1","CD274","IL12RB1","CD38","PDCD1LG2","IL15","HLA-DPB1","TBX21","NOD2","HLA-F","HLA-E","CTLA4","RIPK2","TNFSF13B","VCAM1","FLT3LG","CD80","PDCD1","JAK3","CYLD","BTN2A2","HLA-G","BCL6","CCL5","LYN","IL12A","TNFRSF14","IL7","CD83","IL6","LILRB4","FGF10","EGR3","EBI3","DUSP10","CD86","CD47","RASGRP1","PTPRC","LILRB1","CCL2","PAK1","RUNX1","SRC","TGFB1","ICOS","CCDC88B","IL2RA","CCL19"]} {"pathway":"GO_SCF_DEPENDENT_PROTEASOMAL_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS","pval":0.01548,"padj":0.3215,"ES":0.85811,"NES":1.39172,"nMoreExtreme":1186,"size":86,"leadingEdge":["PSME2","PSMB9","FBXO6","PSME1","PSMB10","PSMB8","PSMA4","PSMA2","CUL1","PSMA5"]} {"pathway":"GO_MAST_CELL_ACTIVATION","pval":0.01587,"padj":0.32448,"ES":0.92101,"NES":1.3917,"nMoreExtreme":1110,"size":48,"leadingEdge":["CD300LF","S100A13","LYN","NR4A3","PLSCR1","CD226","RASGRP1","LCP2","RHOH","FCER1G","CD84"]} {"pathway":"GO_CERAMIDE_BIOSYNTHETIC_PROCESS","pval":0.01233,"padj":0.28197,"ES":0.92948,"NES":1.3916,"nMoreExtreme":855,"size":45,"leadingEdge":["P2RX7","B4GALT5","TNF","SMPD3","ST3GAL5","AGK"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION","pval":0.01601,"padj":0.32558,"ES":0.92082,"NES":1.39141,"nMoreExtreme":1120,"size":48,"leadingEdge":["SOCS1","MVP","PARP14","PTPRC","SOCS3","PTPN2","SRCIN1","SEMA4D","SPINK1"]} {"pathway":"GO_AXON_MIDLINE_CHOICE_POINT_RECOGNITION","pval":0.23845,"padj":0.82177,"ES":0.94417,"NES":1.39103,"nMoreExtreme":12189,"size":3,"leadingEdge":["ROBO1","APP"]} {"pathway":"GO_REGULATION_OF_FLAGELLATED_SPERM_MOTILITY","pval":0.24013,"padj":0.82313,"ES":0.94377,"NES":1.39045,"nMoreExtreme":12275,"size":3,"leadingEdge":["CCR6","CFAP69"]} {"pathway":"GO_TYROSINE_CATABOLIC_PROCESS","pval":0.24183,"padj":0.82373,"ES":0.94338,"NES":1.38987,"nMoreExtreme":12362,"size":3,"leadingEdge":["HPD","GSTZ1"]} {"pathway":"GO_REGULATION_OF_DEFENSE_RESPONSE","pval":0.00001,"padj":0.00325,"ES":0.7639,"NES":1.38875,"nMoreExtreme":0,"size":599,"leadingEdge":["IRF1","TIFA","GBP5","IDO1","PSME2","AIM2","SOCS1","LRRK2","IL12RB1","PSMB9","IL15","SERPING1","LAG3","NOD2","HLA-F","CEACAM1","HGF","NLRC5","PSME1","HLA-E","ACOD1","NMI","OPTN","STAT1","JAK2","SUCNR1","PSMB10","AGT","TRAFD1","RIPK2","TLR8","IL27","PSMB8","KLF4","CLEC6A","MUC1","ZBP1","TGM2","TSPAN32","C3","SLAMF6","APOBEC3G","CLEC10A","CD300LF","MEFV","TLR10","ZC3H12A","CTSS","CYLD","STAP1","IRF7","ICAM2","RSAD2","IFIH1","DTX3L","LILRA2","SBNO2","DDX60","HLA-G","SLAMF8","PTGER4","RELB","BCL6","CCL18","CCL5","LYN","IL12A","PYHIN1","TNFAIP6","PARP14","TLR7","TICAM2","LTA","TANK","PARP9","CTSL","PLSCR1","IRF4","TNFAIP3","LILRA4","BIRC3","MYD88","APOBEC3F","IL6","TLR3","CLEC4D","CLEC4E","SEMA7A","TNF","PSMA4","PSMA2","SERPINB9","CD226","CUL1","DUSP10","CD47","RASGRP1","PIK3AP1","CCL1","PTPRC","DDX58","NR1H3","LILRB1","SOCS3","PTPN2","DHX58","PAK1","MNDA","SRC","A2M","IL2RA","CGAS","WDFY1","PSMA5","IKBKE","SLC7A2","PTPN1","NFKBIA","TREML4","OTUD4","PTGS2","CCL3","CX3CL1","USP18"]} {"pathway":"GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_ENDOTHELIN","pval":0.11104,"padj":0.69788,"ES":0.97489,"NES":1.38828,"nMoreExtreme":5778,"size":4,"leadingEdge":["EDN1","RHOA"]} {"pathway":"GO_REGULATION_OF_PEPTIDASE_ACTIVITY","pval":0.00077,"padj":0.05366,"ES":0.77848,"NES":1.38798,"nMoreExtreme":70,"size":313,"leadingEdge":["PSME2","AIM2","C4A","PSMB9","C4B","SERPING1","LAMP3","HGF","TNFSF10","ATP13A2","PSME1","JAK2","AGT","RIPK2","PZP","FAS","PSMB8","KLF4","BCL2L11","PML","C3","MEFV","CASP4","CARD17","CARD16","PMAIP1","LYN","TANK","BIRC3","CASP10","TNF","SERPINB9","CASP5","F3","STAT3","SRC","A2M","ROBO1","AKIRIN2","UBE2Z","IFI6","SH3RF1","PTGS2","GAS6","PRELID1","CFLAR","BIRC7","CASP1","NKX3-1","SERPINB1","SPINK1","HERPUD1","BBC3","SMAD3","HMSD","BAK1","NGF","TNFAIP8"]} {"pathway":"GO_CHAPERONE_COFACTOR_DEPENDENT_PROTEIN_REFOLDING","pval":0.00022,"padj":0.02273,"ES":0.9982,"NES":1.38719,"nMoreExtreme":13,"size":28,"leadingEdge":["CD74","HSPA5"]} {"pathway":"GO_CYTOCHROME_COMPLEX_ASSEMBLY","pval":0.00511,"padj":0.18466,"ES":0.96695,"NES":1.38625,"nMoreExtreme":338,"size":34,"leadingEdge":["SCO2","HCCS"]} {"pathway":"GO_GRANULOCYTE_COLONY_STIMULATING_FACTOR_PRODUCTION","pval":0.11801,"padj":0.70259,"ES":0.97343,"NES":1.3862,"nMoreExtreme":6141,"size":4,"leadingEdge":["LILRA2","HAVCR2"]} {"pathway":"GO_T_CELL_ACTIVATION","pval":0.00035,"padj":0.03017,"ES":0.77127,"NES":1.38599,"nMoreExtreme":32,"size":381,"leadingEdge":["IRF1","HLA-DPA1","IDO1","HLA-DMB","CD74","HLA-DOA","P2RX7","SOCS1","CD274","IL12RB1","ITK","PDCD1LG2","IL15","LAG3","HLA-DPB1","TBX21","NOD2","CEACAM1","BTN3A1","HLA-E","CTLA4","PSMB10","CD7","RIPK2","TNFSF13B","IL27","VCAM1","ICAM1","TNFSF18","CD80","PDCD1","B2M","SLAMF6","ZC3H12A","JAK3","CYLD","RSAD2","BTN2A2","HLA-G","PTGER4","RELB","BCL6","CCL5","LYN","IL12A","TNFRSF14","IL7","CD83","IRF4","IL6","CLEC4D","CLEC4E","LILRB4","EGR3","EBI3","DUSP10","CD86","GPR18","CD47","RASGRP1","ITGAL","PTPRC","RHOH","LILRB1","CCL2","STAT3","PTPN2","PAK1","RUNX1","SRC","TGFB1","SEMA4A","ICOS","CCDC88B","IL2RA","CCL19","CGAS","CCR6"]} {"pathway":"GO_PROTEIN_POLYUBIQUITINATION","pval":0.00112,"padj":0.06836,"ES":0.781,"NES":1.38534,"nMoreExtreme":101,"size":282,"leadingEdge":["PSME2","PSMB9","FBXO6","NOD2","PSME1","NMI","PSMB10","IFI27","LONRF1","PSMB8","RNF19B","PARP10","TRIM69","DTX3L","DYSF","TNFAIP3","RNF144B","WSB1","PSMA4","PSMA2","RBCK1","CUL1","UBE2A","TRIM71","PSMA5","TRIM21","ZNRF2"]} {"pathway":"GO_LONG_CHAIN_FATTY_ACYL_COA_METABOLIC_PROCESS","pval":0.12522,"padj":0.71701,"ES":0.97197,"NES":1.38412,"nMoreExtreme":6516,"size":4,"leadingEdge":["DGAT2","FAR2"]} {"pathway":"GO_DITERPENOID_BIOSYNTHETIC_PROCESS","pval":0.26143,"padj":0.83152,"ES":0.93912,"NES":1.3836,"nMoreExtreme":13364,"size":3,"leadingEdge":["CYP1A1","DHRS9","ALDH1A2"]} {"pathway":"GO_RECEPTOR_SIGNALING_PATHWAY_VIA_STAT","pval":0.01281,"padj":0.29031,"ES":0.82976,"NES":1.38322,"nMoreExtreme":1027,"size":113,"leadingEdge":["IL31RA","CD40","SOCS1","IL15","NMI","STAT1","JAK2","AGT","STAT2","TNFSF18","JAK3","STAP2","CCL5","LYN","IL12A","PARP14","PARP9","IL6","TNF","STAT5A","PTPRC","SOCS3","CCL2","SH2B2","STAT3","PTPN2","STAT4"]} {"pathway":"GO_PEPTIDYL_TYROSINE_DEPHOSPHORYLATION_INVOLVED_IN_INACTIVATION_OF_PROTEIN_KINASE_ACTIVITY","pval":0.26495,"padj":0.83566,"ES":0.93838,"NES":1.38251,"nMoreExtreme":13544,"size":3,"leadingEdge":["DUSP10","PTPN1","DUSP3"]} {"pathway":"GO_TOLERANCE_INDUCTION_DEPENDENT_UPON_IMMUNE_RESPONSE","pval":0.13167,"padj":0.72756,"ES":0.97062,"NES":1.3822,"nMoreExtreme":6852,"size":4,"leadingEdge":["CD274","HLA-G"]} {"pathway":"GO_LEUKOCYTE_PROLIFERATION","pval":0.0029,"padj":0.12537,"ES":0.78761,"NES":1.38207,"nMoreExtreme":257,"size":229,"leadingEdge":["IRF1","HLA-DPA1","IDO1","HLA-DMB","CD40","CD74","P2RX7","CD274","IL12RB1","CD38","PDCD1LG2","IL15","HLA-DPB1","BTN3A1","HLA-E","CTLA4","PSMB10","RIPK2","TNFSF13B","IL27","VCAM1","FLT3LG","TNFSF18","CD80","CCL8","JAK3","BTN2A2","HLA-G","BCL6","CCL5","LYN","IL12A","CSF1","TNFRSF14","IL7","TNFAIP3","IL6","FGF10","EBI3","CD86","PTPRC","LILRB1","MNDA","TGFB1","OCSTAMP","CCDC88B","IL2RA","CCL19"]} {"pathway":"GO_B_1_B_CELL_DIFFERENTIATION","pval":0.13267,"padj":0.72971,"ES":0.9704,"NES":1.38188,"nMoreExtreme":6904,"size":4,"leadingEdge":["SLAMF8","CMTM7"]} {"pathway":"GO_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE","pval":0.00875,"padj":0.24715,"ES":0.81251,"NES":1.38136,"nMoreExtreme":726,"size":143,"leadingEdge":["IRF1","CD40","P2RX7","CD274","IL12RB1","TBX21","HLA-F","CEACAM1","HLA-B","HLA-E","HLA-A","HLA-C","RIPK2","TNFSF13B","IL27","CD80","B2M","C3","ZC3H12A","JAK3","IRF7","RSAD2","HLA-G","BCL6","IL12A","LTA","TNFRSF14","PARP3","TNFAIP3","IL6","TNF","CD226","DUSP10","PTPRC","LILRB1","TGFB1","CCL19"]} {"pathway":"GO_CELLULAR_BIOGENIC_AMINE_METABOLIC_PROCESS","pval":0.01406,"padj":0.30898,"ES":0.93268,"NES":1.38123,"nMoreExtreme":963,"size":42,"leadingEdge":["IDO1","IDO2","SAT1","KYNU","AZIN2","KMO","GDE1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_DEFENSE_RESPONSE","pval":0.00024,"padj":0.02468,"ES":0.76665,"NES":1.38072,"nMoreExtreme":22,"size":408,"leadingEdge":["IRF1","TIFA","GBP5","IDO1","PSME2","AIM2","LRRK2","PSMB9","IL15","LAG3","NOD2","HLA-F","NLRC5","PSME1","HLA-E","ACOD1","OPTN","JAK2","SUCNR1","PSMB10","AGT","RIPK2","TLR8","PSMB8","CLEC6A","MUC1","ZBP1","TGM2","C3","SLAMF6","CLEC10A","CD300LF","TLR10","CTSS","CYLD","STAP1","IRF7","ICAM2","RSAD2","IFIH1","LILRA2","DDX60","HLA-G","PTGER4","RELB","CCL18","CCL5","LYN","IL12A","PYHIN1","TLR7","TICAM2","LTA","TANK","PARP9","CTSL","PLSCR1","IRF4","TNFAIP3","LILRA4","BIRC3","MYD88","IL6","TLR3","CLEC4D","CLEC4E","TNF","PSMA4","PSMA2","CD226","CUL1","CD47","RASGRP1","PIK3AP1","CCL1","DDX58","NR1H3","DHX58","PAK1","MNDA","SRC","CGAS","WDFY1","PSMA5","IKBKE","NFKBIA","TREML4","OTUD4","PTGS2","CCL3","CX3CL1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_T_CELL_PROLIFERATION","pval":0.02126,"padj":0.36805,"ES":0.85997,"NES":1.3805,"nMoreExtreme":1605,"size":78,"leadingEdge":["HLA-DPA1","HLA-DMB","CD274","IL12RB1","PDCD1LG2","IL15","HLA-DPB1","HLA-E","RIPK2","TNFSF13B","VCAM1","CD80","JAK3","CCL5","IL6","EBI3","CD86","PTPRC","CCDC88B","IL2RA","CCL19"]} {"pathway":"GO_POSITIVE_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS","pval":0.02325,"padj":0.38612,"ES":0.87244,"NES":1.38049,"nMoreExtreme":1720,"size":69,"leadingEdge":["CD74","CXCL10","CCL7","EDN1","VEGFC","DYSF","CCL5","IL12A","CSF1","IL6","CAMK1D","CCL1","CXCL12","CCL4","FPR2","CCL19","CCR6","CXCL8","RIPOR2","GAS6","CCL3","DAPK2"]} {"pathway":"GO_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION","pval":0.00929,"padj":0.24994,"ES":0.81271,"NES":1.38017,"nMoreExtreme":770,"size":141,"leadingEdge":["IRF1","CD74","HLA-DOA","SOCS1","IL12RB1","IL15","TBX21","CTLA4","RIPK2","IL27","FLT3LG","CD80","ZC3H12A","JAK3","CYLD","BTN2A2","HLA-G","SLAMF8","BCL6","IL7","CD83","IRF4","LILRB4","EGR3","DUSP10","CD86","RASGRP1","PTPRC","PTPN2","RUNX1","TGFB1","IL2RA","CCL19","SH3RF1","GAS6","PRELID1","GATA3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS","pval":0.02831,"padj":0.42056,"ES":0.90265,"NES":1.37842,"nMoreExtreme":2003,"size":52,"leadingEdge":["CD74","NLRC5","RIPK2","ZBP1","CD300LF","CASP4","IRF7","EDN1","IFIH1","PARP14","TICAM2","CSF1","PARP9","IL7","DDX58","IKBKE","CREBRF","GAS6","CASP1"]} {"pathway":"GO_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS","pval":0.02738,"padj":0.41718,"ES":0.88748,"NES":1.37803,"nMoreExtreme":1977,"size":59,"leadingEdge":["CD40","JAK2","ICAM1","HLA-G","TNFAIP3","IL6","TNF","CCL2","ANGPTL4","SORT1","GAS6","CFLAR","GATA3","NFE2L2","ZFP36"]} {"pathway":"GO_DICARBOXYLIC_ACID_METABOLIC_PROCESS","pval":0.02552,"padj":0.40216,"ES":0.91193,"NES":1.37797,"nMoreExtreme":1786,"size":48,"leadingEdge":["ACOT4","GGT5","GLUL","GCLC","SDHB","ASS1","MDH1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_UNSATURATED_FATTY_ACID_BIOSYNTHETIC_PROCESS","pval":0.2798,"padj":0.84216,"ES":0.93529,"NES":1.37795,"nMoreExtreme":14303,"size":3,"leadingEdge":["PTGS2","ABCD1"]} {"pathway":"GO_INORGANIC_ION_IMPORT_ACROSS_PLASMA_MEMBRANE","pval":0.02793,"padj":0.41828,"ES":0.89111,"NES":1.37728,"nMoreExtreme":2003,"size":57,"leadingEdge":["ATP1B2","KCNJ10","SLC12A3","KCNJ2","KCNJ15","SLC8A1","SLC12A7","SLC31A1","SLC9A4"]} {"pathway":"GO_ACYL_CARNITINE_TRANSPORT","pval":0.15565,"padj":0.75836,"ES":0.96596,"NES":1.37556,"nMoreExtreme":8100,"size":4,"leadingEdge":["SLC25A45","SLC25A48"]} {"pathway":"GO_REGULATION_OF_SYMBIOSIS_ENCOMPASSING_MUTUALISM_THROUGH_PARASITISM","pval":0.00519,"padj":0.18583,"ES":0.78952,"NES":1.37506,"nMoreExtreme":452,"size":201,"leadingEdge":["CD74","LAMP3","ISG20","STAT1","IFI27","IFITM2","BCL2L11","APOBEC3D","IFITM1","PML","CCL8","APOBEC3A","APOBEC3G","ZC3H12A","PARP10","RSAD2","TRIM31","IFITM3","CHMP4C","DYNLT1","CCL5","IFIT5","LTA","OAS3","PLSCR1","APOBEC3F","TNF","HPN","MX1","CCL4","CXCL8","TRIM21","ADAR","ISG15","CCL3","TRIM25","ZFP36","STOM","OASL","IRF8","GTF2B"]} {"pathway":"GO_LYSOSOMAL_TRANSPORT","pval":0.01884,"padj":0.35375,"ES":0.83874,"NES":1.37453,"nMoreExtreme":1467,"size":95,"leadingEdge":["LRRK2","DTX3L","IGF2R","SNX16","SORT1","NCOA4","C9orf72","GCC2","NPC1","ARSB","RILP"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ISOTYPE_SWITCHING","pval":0.16013,"padj":0.76421,"ES":0.96506,"NES":1.37428,"nMoreExtreme":8333,"size":4,"leadingEdge":["BCL6","PARP3","THOC1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_RESPONSE_TO_INTERFERON_GAMMA","pval":0.16215,"padj":0.76748,"ES":0.96467,"NES":1.37372,"nMoreExtreme":8438,"size":4,"leadingEdge":["NLRC5","PARP9","TXK"]} {"pathway":"GO_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY","pval":0.02999,"padj":0.43424,"ES":0.88589,"NES":1.37288,"nMoreExtreme":2159,"size":58,"leadingEdge":["TIFA","NOD2","RIPK2","CYLD","IRF7","IFIH1","DDX60","TNFAIP3","BIRC3","DDX58","DHX58","NFKBIA"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_LAMELLIPODIUM_ASSEMBLY","pval":0.27433,"padj":0.83769,"ES":0.92041,"NES":1.37285,"nMoreExtreme":13785,"size":2,"leadingEdge":["SLIT2","PLXNB3"]} {"pathway":"GO_ADENOSINE_METABOLIC_PROCESS","pval":0.29567,"padj":0.85688,"ES":0.93181,"NES":1.37282,"nMoreExtreme":15114,"size":3,"leadingEdge":["ACPP","NT5C2"]} {"pathway":"GO_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS","pval":0.01432,"padj":0.31003,"ES":0.81976,"NES":1.37279,"nMoreExtreme":1156,"size":119,"leadingEdge":["AIM2","CD274","IL12RB1","IL15","CEACAM1","ACOD1","OPTN","STAT1","RIPK2","IL27","TSPAN32","APOBEC3G","ZC3H12A","CARD16","DTX3L","LILRA2","DDX60","IL12A","PARP9","TNFAIP3","BIRC3","APOBEC3F","CD226","DDX58","LILRB1","DHX58","IL2RA","CGAS"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELL_ADHESION","pval":0.00099,"padj":0.06189,"ES":0.76749,"NES":1.37236,"nMoreExtreme":91,"size":337,"leadingEdge":["HLA-DPA1","HLA-DMB","CD74","SOCS1","CD274","IL12RB1","PDCD1LG2","IL15","HLA-DPB1","NOD2","HLA-E","CHRD","CTLA4","JAK2","RIPK2","TNFSF13B","VCAM1","ICAM1","TGM2","RSU1","TNFSF18","CD80","PDCD1","JAK3","CYLD","BTN2A2","S100A10","DYSF","HLA-G","BCL6","CCL5","LYN","IL12A","CSF1","NR4A3","TNFRSF14","IL7","PTPRU","CD83","IL6","LILRB4","EGR3","TNF","EBI3","DUSP10","CD86","CD47","RASGRP1","CXCL12","PTPRC","PTAFR","LILRB1","CCL2","P2RY12","PAK1","PODXL","RUNX1","SRC","TGFB1","ICOS","CCDC88B","IL2RA","CCL19"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_PROLIFERATION","pval":0.0089,"padj":0.24715,"ES":0.99758,"NES":1.37226,"nMoreExtreme":470,"size":5,"leadingEdge":["CD274","ARG2"]} {"pathway":"GO_REGULATION_OF_VACUOLAR_TRANSPORT","pval":0.00909,"padj":0.24715,"ES":0.99753,"NES":1.37218,"nMoreExtreme":480,"size":5,"leadingEdge":["LRRK2","VPS35"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PROTEIN_TARGETING_TO_MITOCHONDRION","pval":0.00909,"padj":0.24715,"ES":0.99753,"NES":1.37218,"nMoreExtreme":480,"size":5,"leadingEdge":["LRRK2","LMAN1"]} {"pathway":"GO_REGULATION_OF_BRANCHING_MORPHOGENESIS_OF_A_NERVE","pval":0.00909,"padj":0.24715,"ES":0.99753,"NES":1.37218,"nMoreExtreme":480,"size":5,"leadingEdge":["LRRK2","MAP3K13"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_4_PRODUCTION","pval":0.16808,"padj":0.77295,"ES":0.96349,"NES":1.37204,"nMoreExtreme":8747,"size":4,"leadingEdge":["CD83","NDFIP1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_PROLIFERATION","pval":0.02915,"padj":0.42796,"ES":0.87819,"NES":1.37187,"nMoreExtreme":2122,"size":62,"leadingEdge":["IDO1","CD274","PDCD1LG2","CTLA4","CD80","CCL8","BTN2A2","HLA-G","LYN","TNFRSF14","TNFAIP3","CD86","LILRB1","MNDA","TGFB1","IL2RA"]} {"pathway":"GO_PROTEIN_K29_LINKED_DEUBIQUITINATION","pval":0.17,"padj":0.77295,"ES":0.96315,"NES":1.37156,"nMoreExtreme":8847,"size":4,"leadingEdge":["TNFAIP3","ZRANB1"]} {"pathway":"GO_PEROXISOME_ORGANIZATION","pval":0.02636,"padj":0.40796,"ES":0.86182,"NES":1.37134,"nMoreExtreme":1966,"size":72,"leadingEdge":["PLAAT3","ACOT4","GSTK1","CROT"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TRIGLYCERIDE_BIOSYNTHETIC_PROCESS","pval":0.27748,"padj":0.84047,"ES":0.91934,"NES":1.37126,"nMoreExtreme":13943,"size":2,"leadingEdge":["SIK1","FBXW7"]} {"pathway":"GO_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE","pval":0.0219,"padj":0.37476,"ES":0.8441,"NES":1.37085,"nMoreExtreme":1682,"size":87,"leadingEdge":["IL31RA","CD74","TBX21","NOD2","HLA-F","HLA-E","B2M","JAK3","RSAD2","HLA-G","BCL6","NR4A3","TNFRSF14","DENND1B","IL6","TLR3","SEMA7A","TNF","MR1","CD226","DDX58","LILRB1","TGFB1","GAS6","GATA3"]} {"pathway":"GO_VOLUNTARY_SKELETAL_MUSCLE_CONTRACTION","pval":0.17584,"padj":0.77529,"ES":0.96203,"NES":1.36997,"nMoreExtreme":9151,"size":4,"leadingEdge":["MYH7","TNNT1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_RECEPTOR_SIGNALING_PATHWAY_VIA_STAT","pval":0.02945,"padj":0.43049,"ES":0.87522,"NES":1.36991,"nMoreExtreme":2150,"size":63,"leadingEdge":["IL31RA","CD40","SOCS1","IL15","JAK2","AGT","TNFSF18","STAP2","CCL5","LYN","IL12A","PARP14","PARP9","IL6","TNF","SOCS3","STAT3"]} {"pathway":"GO_REGULATION_OF_THYROID_HORMONE_GENERATION","pval":0.30592,"padj":0.86262,"ES":0.92973,"NES":1.36976,"nMoreExtreme":15638,"size":3,"leadingEdge":["HPN","GATA3","PAX8"]} {"pathway":"GO_AMINO_ACID_ACTIVATION","pval":0.00554,"padj":0.1941,"ES":0.97519,"NES":1.36966,"nMoreExtreme":360,"size":30,"leadingEdge":["PPA1","LARS2"]} {"pathway":"GO_REGULATION_OF_MEMBRANE_REPOLARIZATION_DURING_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL","pval":0.17763,"padj":0.77529,"ES":0.96163,"NES":1.36941,"nMoreExtreme":9244,"size":4,"leadingEdge":["RNF207","DLG1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PROTEIN_DEPHOSPHORYLATION","pval":0.03388,"padj":0.472,"ES":0.89384,"NES":1.36881,"nMoreExtreme":2405,"size":53,"leadingEdge":["LMTK2","TNF","ELFN1","MYOZ1","PPP1R16B","PTN"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_T_CELL_CYTOKINE_PRODUCTION","pval":0.02171,"padj":0.37332,"ES":0.99472,"NES":1.36831,"nMoreExtreme":1148,"size":5,"leadingEdge":["TBX21","HLA-F","HFE"]} {"pathway":"GO_INSULIN_METABOLIC_PROCESS","pval":0.02241,"padj":0.37912,"ES":0.99455,"NES":1.36808,"nMoreExtreme":1185,"size":5,"leadingEdge":["CEACAM1","ERO1B"]} {"pathway":"GO_TYPE_II_PNEUMOCYTE_DIFFERENTIATION","pval":0.18562,"padj":0.77993,"ES":0.95995,"NES":1.36701,"nMoreExtreme":9660,"size":4,"leadingEdge":["FGF10","AIMP2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_HEMOPOIESIS","pval":0.0182,"padj":0.35354,"ES":0.82112,"NES":1.3655,"nMoreExtreme":1453,"size":110,"leadingEdge":["IRF1","CD74","SOCS1","TBX21","CEACAM1","CTLA4","TMEM176A","TMEM176B","LILRB3","ZC3H12A","JAK3","HLA-G","BCL6","LYN","TLR3","LILRB4","LILRB1","PTPN2","RUNX1","C1QC","NFKBIA","CCL3","NFE2L2","ZFP36","HLX","TLR4","IFNL1"]} {"pathway":"GO_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT","pval":0.00491,"padj":0.17849,"ES":0.77899,"NES":1.3651,"nMoreExtreme":434,"size":223,"leadingEdge":["P2RX7","ABCC11","SIDT2","MVP","SLC25A25","PARP11","SLC29A3","ZFP36","FLOT1","ARC","SLC35C2"]} {"pathway":"GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS_EXONUCLEOLYTIC","pval":0.01902,"padj":0.35444,"ES":0.93544,"NES":1.36486,"nMoreExtreme":1285,"size":38,"leadingEdge":["ISG20","XRN1","ZC3H12A","ERI1"]} {"pathway":"GO_MYELOID_LEUKOCYTE_ACTIVATION","pval":0.00009,"padj":0.01306,"ES":0.75159,"NES":1.36465,"nMoreExtreme":8,"size":564,"leadingEdge":["IL31RA","UBD","CD74","LRRK2","IL15","CEACAM1","ADGRE5","SELL","BATF2","PADI2","SUCNR1","FGL2","TLR8","BATF3","LILRB3","ENPP4","FLT3LG","GSDMD","TSPAN32","B2M","C3","CD300LF","S100A13","ZC3H12A","CTSS","STAP1","SLAMF1","IGF2R","MVP","LILRA2","SBNO2","DYSF","DYNLT1","RELB","CCL5","LYN","TNFAIP6","MMP25","TLR7","TICAM2","CSF1","NR4A3","PLSCR1","IRF4","ANXA3","CTSZ","IL6","TLR3","CLEC4D","TNF","PSMA2","CD226","CD47","RASGRP1","RAB24","ITGAL","LCP2","PTPRC","CHI3L1","RHOH","PTAFR","NR1H3","FPR2","MNDA","TGFB1","CXCL8","PSMA5","NAMPT","ADA2","CTSC","GM2A","SLC7A2","CREG1","HVCN1","CCL3","CX3CL1","ACPP","SLC44A2","MT1G","IL33","DNAJC13","SERPINB1","CD53","GNS","CRISPLD2","STOM","NFAM1","FCER1G"]} {"pathway":"GO_LEUKOCYTE_MEDIATED_IMMUNITY","pval":0.00004,"padj":0.00761,"ES":0.74935,"NES":1.36459,"nMoreExtreme":3,"size":651,"leadingEdge":["IL31RA","CD40","C4A","CD74","P2RX7","IL12RB1","SLAMF7","C4B","SERPING1","LAG3","TBX21","C1QB","NOD2","HLA-F","CEACAM1","ADGRE5","HLA-DQB1","BTN3A2","HLA-B","SELL","HLA-E","HLA-A","PADI2","HLA-C","FGL2","TLR8","BTN3A3","C2","ICAM1","LILRB3","ENPP4","GSDMD","B2M","C3","SLAMF6","S100A13","CTSS","JAK3","IRF7","RSAD2","C1S","C1RL","IGF2R","MVP","C1R","HLA-G","GCNT3","DYNLT1","BCL6","LYN","IL12A","TNFAIP6","MMP25","TICAM2","LTA","NR4A3","PARP3","DENND1B","ANXA3","CTSZ","IL6","TLR3","CLEC4D","TNF","PSMA2","SERPINB9","CD226","CD47","RASGRP1","RAB24","ITGAL","PTPRC","CHI3L1","PTAFR","DDX58","LILRB1","FPR2","NBN","MNDA","TGFB1","CCR6","C1QC","PSMA5","PRDX1","ADA2","CTSC","GM2A","CREG1","HVCN1","LIG4","CCL3","ACPP","SLC44A2","GATA3","DNAJC13","SERPINB1","CD53","GNS","CRISPLD2","MICB","STOM","NFAM1","FCER1G"]} {"pathway":"GO_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY","pval":0.00713,"padj":0.22093,"ES":0.78533,"NES":1.36414,"nMoreExtreme":618,"size":193,"leadingEdge":["AIM2","PSMB9","LAMP3","HGF","TNFSF10","JAK2","RIPK2","FAS","KLF4","BCL2L11","PML","MEFV","CASP4","CARD16","PMAIP1","BIRC3","CASP10","TNF","SERPINB9","CASP5","F3","SRC","ROBO1","IFI6","SH3RF1","PTGS2","GAS6","CFLAR","BIRC7","CASP1","NKX3-1","HERPUD1","BBC3","SMAD3","BAK1","NGF","TNFAIP8"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_BICELLULAR_TIGHT_JUNCTION_ASSEMBLY","pval":0.1961,"padj":0.79009,"ES":0.95781,"NES":1.36397,"nMoreExtreme":10205,"size":4,"leadingEdge":["TNF","ROCK1"]} {"pathway":"GO_METANEPHRIC_TUBULE_FORMATION","pval":0.19635,"padj":0.79066,"ES":0.95776,"NES":1.36389,"nMoreExtreme":10218,"size":4,"leadingEdge":["SOX8","SOX9"]} {"pathway":"GO_REGULATION_OF_TRAIL_ACTIVATED_APOPTOTIC_SIGNALING_PATHWAY","pval":0.03714,"padj":0.49711,"ES":0.99146,"NES":1.36383,"nMoreExtreme":1964,"size":5,"leadingEdge":["ATF3","TIMP3"]} {"pathway":"GO_TAURINE_METABOLIC_PROCESS","pval":0.19861,"padj":0.79183,"ES":0.95731,"NES":1.36325,"nMoreExtreme":10336,"size":4,"leadingEdge":["STAT5A","PHGDH"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE","pval":0.03858,"padj":0.50613,"ES":0.90216,"NES":1.36321,"nMoreExtreme":2700,"size":48,"leadingEdge":["CD74","NOD2","HLA-F","HLA-E","B2M","RSAD2","HLA-G","NR4A3","TNFRSF14","IL6","SEMA7A","CD226","DDX58","LILRB1","GATA3","FCER1G","TLR4"]} {"pathway":"GO_REGULATION_OF_MESENCHYMAL_TO_EPITHELIAL_TRANSITION_INVOLVED_IN_METANEPHROS_MORPHOGENESIS","pval":0.04075,"padj":0.51749,"ES":0.99073,"NES":1.36283,"nMoreExtreme":2155,"size":5,"leadingEdge":["STAT1","PAX8"]} {"pathway":"GO_PROTEIN_HYDROXYLATION","pval":0.00209,"padj":0.10115,"ES":0.99246,"NES":1.36259,"nMoreExtreme":133,"size":26,"leadingEdge":["ASPHD2","JMJD6"]} {"pathway":"GO_CELL_KILLING","pval":0.02276,"padj":0.38138,"ES":0.83134,"NES":1.3624,"nMoreExtreme":1772,"size":95,"leadingEdge":["APOL1","P2RX7","IL12RB1","SLAMF7","LAG3","HLA-F","CEACAM1","CCL13","HLA-B","HLA-E","HLA-A","HLA-C","ICAM1","BCL2L11","B2M","SLAMF6","STAP1","HLA-G","IL12A","SERPINB9","CD226","RASGRP1","PTPRC","LILRB1","PRDX1","CTSC"]} {"pathway":"GO_HEPARAN_SULFATE_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS_ENZYMATIC_MODIFICATION","pval":0.20276,"padj":0.79569,"ES":0.95647,"NES":1.36205,"nMoreExtreme":10552,"size":4,"leadingEdge":["HS3ST3B1","HS6ST1"]} {"pathway":"GO_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE","pval":0.01778,"padj":0.35083,"ES":0.81451,"NES":1.36187,"nMoreExtreme":1432,"size":117,"leadingEdge":["CD40","CD74","TBX21","NOD2","HLA-F","HLA-E","B2M","JAK3","RSAD2","HLA-G","BCL6","NR4A3","TNFRSF14","PARP3","IL6","TLR3","SEMA7A","TNF","CD226","PTPRC","DDX58","LILRB1","TGFB1","CGAS","GATA3","IL33"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PHENOTYPIC_SWITCHING","pval":0.33176,"padj":0.87332,"ES":0.92434,"NES":1.36182,"nMoreExtreme":16959,"size":3,"leadingEdge":["SOD2","PDGFB"]} {"pathway":"GO_CYTOKINE_SECRETION","pval":0.00928,"padj":0.24994,"ES":0.78865,"NES":1.36177,"nMoreExtreme":794,"size":177,"leadingEdge":["GBP5","AIM2","GBP1","P2RX7","SOCS1","CD274","LRRK2","NOD2","BTN3A2","CLEC9A","BTN3A1","BANK1","AGT","RIPK2","TLR8","MCOLN2","CLEC6A","GSDMD","PML","S100A13","TLR10","ZC3H12A","CARD17","CARD16","BTN2A2","IFIH1","LILRA2","DYSF","PTGER4","LYN","TNFRSF14","TNFAIP3","CLEC4E","TNF","RASGRP1","CCL1","LCP2","CHI3L1","DDX58","LILRB1","SRC","CCL19","GAS6","CCL3","CX3CL1","GATA3","CASP1","IL33"]} {"pathway":"GO_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION","pval":0.03745,"padj":0.49711,"ES":0.88922,"NES":1.36174,"nMoreExtreme":2658,"size":53,"leadingEdge":["SOCS1","IL12RB1","TBX21","RIPK2","IL27","CD80","ZC3H12A","JAK3","BCL6","CD83","IRF4","CD86","RUNX1","CCL19","SH3RF1","GATA3","HLX"]} {"pathway":"GO_REGULATION_OF_VASCULAR_SMOOTH_MUSCLE_CELL_DEDIFFERENTIATION","pval":0.33203,"padj":0.87332,"ES":0.92428,"NES":1.36173,"nMoreExtreme":16973,"size":3,"leadingEdge":["PDGFB","OLFM2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_LEUKOCYTE_PROLIFERATION","pval":0.01919,"padj":0.35444,"ES":0.81833,"NES":1.36169,"nMoreExtreme":1533,"size":111,"leadingEdge":["HLA-DPA1","HLA-DMB","CD40","CD74","CD274","IL12RB1","CD38","PDCD1LG2","IL15","HLA-DPB1","HLA-E","RIPK2","TNFSF13B","VCAM1","FLT3LG","CD80","JAK3","BCL6","CCL5","LYN","IL12A","CSF1","IL7","IL6","FGF10","EBI3","CD86","PTPRC","OCSTAMP","CCDC88B","IL2RA","CCL19"]} {"pathway":"GO_MULTIVESICULAR_BODY_ORGANIZATION","pval":0.00818,"padj":0.23818,"ES":0.96951,"NES":1.36168,"nMoreExtreme":532,"size":30,"leadingEdge":["CHMP4C","VTA1"]} {"pathway":"GO_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN","pval":0.00278,"padj":0.12135,"ES":0.76821,"NES":1.36152,"nMoreExtreme":252,"size":276,"leadingEdge":["IL18BP","IDO1","CD40","P2RX7","CD274","GCH1","CXCL11","C4B","PDCD1LG2","PDE4B","CXCL10","NOD2","ACOD1","CXCL9","JAK2","RIPK2","VCAM1","CYP1A1","ICAM1","CD80","CSF2RB","B2M","ZC3H12A","CARD17","STAP1","CARD16","IL12RB2","EDN1","LILRA2","IL1RN","SBNO2","PTGER4","CMPK2","LITAF","CCL5","LYN","IL12A","TICAM2","LTA","PLSCR4","TNFAIP3","IL6","FGF10","NFKB2","TNF","PTGER2","DUSP10","CD86","CCR5","CYP27B1","PTAFR","NR1H3","LILRB1","CCL2","KMO","SRC","TGFB1","CXCL8","AKIRIN2","NFKBIA","PTGS2","CCL3","IRF5","CX3CL1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING","pval":0.01036,"padj":0.25928,"ES":0.78997,"NES":1.36115,"nMoreExtreme":883,"size":171,"leadingEdge":["TIFA","APOL3","UBD","CD40","CD74","NOD2","TNFSF10","SECTM1","RIPK2","CLEC6A","TGM2","TRIM22","S100A13","CARD16","IL1RN","LITAF","IFIT5","TICAM2","BIRC3","MYD88","CASP10","TLR3","TNF","RBCK1","CCL19","IKBKE","LPAR1","CX3CL1","TRIM25","CFLAR","SLC44A2","CASP1"]} {"pathway":"GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING","pval":0.04662,"padj":0.53858,"ES":0.98938,"NES":1.36097,"nMoreExtreme":2466,"size":5,"leadingEdge":["AGT","APOE"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY","pval":0.03434,"padj":0.47454,"ES":0.86947,"NES":1.36091,"nMoreExtreme":2507,"size":63,"leadingEdge":["SPTBN4","SCIN","TNF","SPTA1","CLEC16A"]} {"pathway":"GO_NATURAL_KILLER_CELL_CYTOKINE_PRODUCTION","pval":0.20749,"padj":0.79637,"ES":0.95562,"NES":1.36085,"nMoreExtreme":10798,"size":4,"leadingEdge":["HLA-F","HLA-E","HLA-G","CD226"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_RESPIRATORY_BURST_INVOLVED_IN_INFLAMMATORY_RESPONSE","pval":0.20926,"padj":0.79637,"ES":0.95529,"NES":1.36037,"nMoreExtreme":10890,"size":4,"leadingEdge":["SLAMF8","DUSP10","GRN"]} {"pathway":"GO_REGULATION_OF_RNA_METABOLIC_PROCESS","pval":0.00742,"padj":0.22598,"ES":0.78133,"NES":1.36025,"nMoreExtreme":646,"size":199,"leadingEdge":["ZC3H12A","OAS2","OAS3","RBM11","TGFB1","LIN28A","OASL","RBM5"]} {"pathway":"GO_SPLICEOSOMAL_SNRNP_ASSEMBLY","pval":0.02086,"padj":0.36541,"ES":0.93618,"NES":1.36018,"nMoreExtreme":1402,"size":37,"leadingEdge":["PRPF3","STRAP"]} {"pathway":"GO_RESPONSE_TO_BACTERIUM","pval":0.00065,"padj":0.04732,"ES":0.75447,"NES":1.35987,"nMoreExtreme":61,"size":417,"leadingEdge":["IL18BP","GBP5","IDO1","CD40","P2RX7","CD274","GCH1","CXCL11","C4B","PDCD1LG2","PDE4B","CXCL10","NOD2","NLRC5","HLA-E","ACOD1","BANK1","CXCL9","OPTN","JAK2","RIPK2","PLAAT3","IL27","VCAM1","CYP1A1","ICAM1","CD80","GSDMD","FAM20A","CSF2RB","B2M","C3","ZC3H12A","CARD17","STAP1","CARD16","IL12RB2","EDN1","C15orf48","GBP6","LILRA2","IL1RN","SBNO2","SLAMF8","TMEM255A","PTGER4","CMPK2","LITAF","CCL5","LYN","IL12A","OAS2","TICAM2","LTA","TNFRSF14","PLSCR4","TNFAIP3","ANXA3","TMEM229B","OCIAD2","MYD88","IL6","TLR3","CLEC4D","CLEC4E","FGF10","NFKB2","TNF","PTGER2","MR1","SERPINB9","VGF","DUSP10","CD86","CD47","CCR5","CYP27B1","PTAFR","NR1H3","LILRB1","CCL2","KMO","DHX58","SRC","TGFB1","CXCL8","AKIRIN2","NFKBIA","ADGRB1","ISG15","PTGS2","CCL3","RGS1","IRF5","CX3CL1","CFLAR","CASP1","MPEG1"]} {"pathway":"GO_MAINTENANCE_OF_PRESYNAPTIC_ACTIVE_ZONE_STRUCTURE","pval":0.05105,"padj":0.55514,"ES":0.98843,"NES":1.35966,"nMoreExtreme":2700,"size":5,"leadingEdge":["ERC2","RAB3A"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY","pval":0.01627,"padj":0.32909,"ES":0.8068,"NES":1.35946,"nMoreExtreme":1329,"size":128,"leadingEdge":["PSME2","LRRK2","PSMB9","PSME1","DKK2","PSMB10","PSMB8","AMER1","FGF10","PSMA4","PSMA2","SRC","PSMA5"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION","pval":0.02553,"padj":0.40216,"ES":0.92759,"NES":1.35939,"nMoreExtreme":1733,"size":39,"leadingEdge":["IRF1","CD74","SOCS1","TBX21","CTLA4","ZC3H12A","JAK3","BCL6","PTPN2","RUNX1"]} {"pathway":"GO_NUCLEOBASE_CATABOLIC_PROCESS","pval":0.05469,"padj":0.56232,"ES":0.9877,"NES":1.35866,"nMoreExtreme":2893,"size":5,"leadingEdge":["DPYS","ALDH6A1"]} {"pathway":"GO_LYMPHOCYTE_ACTIVATION","pval":0.00014,"padj":0.01728,"ES":0.74827,"NES":1.35752,"nMoreExtreme":13,"size":543,"leadingEdge":["IRF1","HLA-DPA1","IDO1","HLA-DMB","CD40","CD74","HLA-DOA","P2RX7","SOCS1","CD274","IL12RB1","ITK","SLAMF7","CD38","PDCD1LG2","IL15","LAG3","HLA-DPB1","TBX21","NOD2","HLA-F","CEACAM1","BTN3A1","HLA-E","BANK1","CTLA4","PSMB10","CD7","RIPK2","TNFSF13B","IL27","VCAM1","ICAM1","FLT3LG","TNFSF18","CD80","PDCD1","B2M","SLAMF6","ZC3H12A","JAK3","CYLD","RSAD2","BTN2A2","SLAMF1","HLA-G","SLAMF8","PTGER4","RELB","BCL6","CCL5","LYN","IL12A","TNFRSF14","PARP3","IL7","CD83","IRF4","TNFAIP3","IL6","CLEC4D","CLEC4E","LILRB4","FGF10","EGR3","NOTCH2","EBI3","DUSP10","CD86","GPR18","CD47","RASGRP1","ITGAL","PTPRC","RHOH","LILRB1","TPD52","KLF6","CCL2","STAT3","NBN","PTPN2","PAK1","MNDA","RUNX1","SRC","TGFB1","SEMA4A","ICOS","CCDC88B","IL2RA","CCL19","CGAS","CCR6","PRDX1"]} {"pathway":"GO_CELL_ACTIVATION","pval":0.00001,"padj":0.00325,"ES":0.74154,"NES":1.35747,"nMoreExtreme":0,"size":1131,"leadingEdge":["IRF1","HLA-DPA1","IL31RA","IDO1","UBD","HLA-DMB","CD40","CD74","HLA-DOA","P2RX7","SOCS1","CD274","LRRK2","IL12RB1","ITK","SLAMF7","CD38","PDCD1LG2","IL15","LAG3","HLA-DPB1","TBX21","CXCL10","NOD2","HLA-F","CEACAM1","ADGRE5","PLEK","SELL","BTN3A1","HLA-E","BATF2","BANK1","PADI2","CTLA4","JAK2","SUCNR1","PSMB10","FGL2","CD7","RIPK2","TLR8","BATF3","TNFSF13B","IL27","VCAM1","ICAM1","LILRB3","ENPP4","FLT3LG","TNFSF18","CD80","GSDMD","PDCD1","TSPAN32","B2M","C3","SLAMF6","CD300LF","S100A13","ZC3H12A","CTSS","JAK3","CYLD","P2RX4","STAP1","RSAD2","BTN2A2","EDN1","SLAMF1","IGF2R","MVP","LILRA2","SBNO2","COMP","DYSF","HLA-G","SLAMF8","PTGER4","DYNLT1","RELB","BCL6","CCL5","LYN","IL12A","TNFAIP6","MMP25","TLR7","TICAM2","CSF1","NR4A3","TNFRSF14","PARP3","IL7","PLSCR1","CD83","IRF4","TNFAIP3","ANXA3","CTSZ","IL6","TLR3","CLEC4D","CLEC4E","LILRB4","FGF10","EGR3","NFKB2","NOTCH2","TNF","EBI3","PSMA2","DGKG","CD226","DUSP10","CD86","GPR18","CD47","RASGRP1","F2RL2","RAB24","ITGAL","LCP2","PTPRC","CHI3L1","RHOH","PTAFR","NR1H3","LILRB1","FPR2","TPD52","KLF6","CCL2","STAT3","NBN","P2RY12","PTPN2","PAK1","MNDA","GCLC","RUNX1","SRC","TGFB1","SEMA4A","ICOS","CCDC88B","IL2RA","CCL19","CGAS","CCR6","CXCL8","PSMA5","GP1BA","PRDX1","PDGFRA","NAMPT","ADA2","CTSC","GM2A","SLC7A2","CREG1","HVCN1","LIG4","SH3RF1","RIPOR2","GAS6","CCL3","CX3CL1","ACPP","PRELID1","TCIM","SLC44A2","GATA3","MT1G","IL33","DNAJC13","SERPINB1","CD53","TREML2","PLCB1","PDGFB","GNS","SMAD3","IL21R","CRISPLD2","MICB","SPTA1","BAK1","STOM","MAP3K8","NFAM1","FCER1G"]} {"pathway":"GO_REGULATION_OF_VACUOLE_ORGANIZATION","pval":0.03019,"padj":0.43469,"ES":0.92281,"NES":1.35712,"nMoreExtreme":2057,"size":40,"leadingEdge":["LRRK2","RALB","C9orf72"]} {"pathway":"GO_SPHINGOMYELIN_METABOLIC_PROCESS","pval":0.22194,"padj":0.80586,"ES":0.95293,"NES":1.35701,"nMoreExtreme":11550,"size":4,"leadingEdge":["SMPD3","SMPD2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MACROPHAGE_APOPTOTIC_PROCESS","pval":0.22194,"padj":0.80586,"ES":0.95293,"NES":1.35701,"nMoreExtreme":11550,"size":4,"leadingEdge":["NOD2","IRF7","CCR5"]} {"pathway":"GO_RUFFLE_ASSEMBLY","pval":0.02335,"padj":0.38612,"ES":0.93385,"NES":1.3568,"nMoreExtreme":1570,"size":37,"leadingEdge":["SNX10","ICAM1","STAP1","P2RY12","COBL"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_2_BIOSYNTHETIC_PROCESS","pval":0.34731,"padj":0.88271,"ES":0.92086,"NES":1.35669,"nMoreExtreme":17754,"size":3,"leadingEdge":["LAG3","PTPRC","ZFP36"]} {"pathway":"GO_CARBON_CATABOLITE_REGULATION_OF_TRANSCRIPTION","pval":0.22617,"padj":0.81244,"ES":0.95214,"NES":1.35589,"nMoreExtreme":11770,"size":4,"leadingEdge":["NCOA1","USF2"]} {"pathway":"GO_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY","pval":0.01152,"padj":0.27642,"ES":0.7882,"NES":1.35579,"nMoreExtreme":980,"size":167,"leadingEdge":["CD40","P2RX7","IL12RB1","LAG3","TBX21","NOD2","HLA-F","CEACAM1","HLA-B","HLA-E","HLA-A","HLA-C","B2M","C3","SLAMF6","JAK3","RSAD2","HLA-G","BCL6","LYN","IL12A","LTA","PARP3","IL6","TLR3","TNF","SERPINB9","CD226","RASGRP1","PTPRC","PTAFR","DDX58","LILRB1","TGFB1"]} {"pathway":"GO_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_I_PROMOTER","pval":0.01976,"padj":0.36056,"ES":0.94125,"NES":1.35569,"nMoreExtreme":1316,"size":35,"leadingEdge":["TAF1A","MNAT1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_ADHESION_TO_VASCULAR_ENDOTHELIAL_CELL","pval":0.22909,"padj":0.81508,"ES":0.95152,"NES":1.35501,"nMoreExtreme":11922,"size":4,"leadingEdge":["KLF4","CXCL12"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_HIGH_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY","pval":0.22951,"padj":0.81508,"ES":0.95147,"NES":1.35493,"nMoreExtreme":11944,"size":4,"leadingEdge":["DYSF","GEM","REM2"]} {"pathway":"GO_MEMBRANE_TO_MEMBRANE_DOCKING","pval":0.06737,"padj":0.60666,"ES":0.98494,"NES":1.35487,"nMoreExtreme":3564,"size":5,"leadingEdge":["VCAM1","ICAM1","ROCK1"]} {"pathway":"GO_T_CELL_ANTIGEN_PROCESSING_AND_PRESENTATION","pval":0.06762,"padj":0.60666,"ES":0.98489,"NES":1.35479,"nMoreExtreme":3577,"size":5,"leadingEdge":["ICAM1","HFE"]} {"pathway":"GO_ESTABLISHMENT_OF_SERTOLI_CELL_BARRIER","pval":0.06762,"padj":0.60666,"ES":0.98489,"NES":1.35479,"nMoreExtreme":3577,"size":5,"leadingEdge":["ICAM1","ARID4A"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_RELAXATION_OF_MUSCLE","pval":0.23085,"padj":0.81508,"ES":0.95119,"NES":1.35453,"nMoreExtreme":12014,"size":4,"leadingEdge":["PDE4B","TIFAB","NEUROG1"]} {"pathway":"GO_T_CELL_DIFFERENTIATION","pval":0.00835,"padj":0.24051,"ES":0.7783,"NES":1.35443,"nMoreExtreme":727,"size":198,"leadingEdge":["IRF1","CD74","HLA-DOA","SOCS1","IL12RB1","ITK","IL15","TBX21","CTLA4","RIPK2","IL27","CD80","B2M","SLAMF6","ZC3H12A","JAK3","CYLD","RSAD2","BTN2A2","HLA-G","PTGER4","RELB","BCL6","IL7","CD83","IRF4","IL6","CLEC4D","CLEC4E","LILRB4","EGR3","DUSP10","CD86","GPR18","RASGRP1","PTPRC","RHOH","STAT3","PTPN2","RUNX1","TGFB1","SEMA4A","IL2RA","CCL19","CCR6","LIG4","SH3RF1","PRELID1","GATA3"]} {"pathway":"GO_MEMBRANE_RAFT_LOCALIZATION","pval":0.23162,"padj":0.81508,"ES":0.95102,"NES":1.35429,"nMoreExtreme":12054,"size":4,"leadingEdge":["PTPRC","RALA"]} {"pathway":"GO_REGULATION_OF_PROTEIN_DEPOLYMERIZATION","pval":0.03315,"padj":0.46617,"ES":0.84823,"NES":1.35413,"nMoreExtreme":2484,"size":74,"leadingEdge":["PLEK","SPTBN4","SCIN","ACTN2","SPTA1"]} {"pathway":"GO_DYNAMIN_FAMILY_PROTEIN_POLYMERIZATION_INVOLVED_IN_MEMBRANE_FISSION","pval":0.2331,"padj":0.81557,"ES":0.95074,"NES":1.35389,"nMoreExtreme":12131,"size":4,"leadingEdge":["MX1","DNM1L"]} {"pathway":"GO_POSITIVE_REGULATION_OF_LIPOPROTEIN_PARTICLE_CLEARANCE","pval":0.23364,"padj":0.81652,"ES":0.95062,"NES":1.35373,"nMoreExtreme":12159,"size":4,"leadingEdge":["LIPG","GPLD1"]} {"pathway":"GO_MUSCLE_HYPERPLASIA","pval":0.0713,"padj":0.62112,"ES":0.98405,"NES":1.35363,"nMoreExtreme":3772,"size":5,"leadingEdge":["KLF4","HMOX1"]} {"pathway":"GO_REGULATION_OF_T_CELL_DIFFERENTIATION","pval":0.02052,"padj":0.36211,"ES":0.80942,"NES":1.35335,"nMoreExtreme":1653,"size":117,"leadingEdge":["IRF1","CD74","HLA-DOA","SOCS1","IL12RB1","IL15","TBX21","CTLA4","RIPK2","IL27","CD80","ZC3H12A","JAK3","CYLD","BTN2A2","HLA-G","BCL6","IL7","CD83","IRF4","LILRB4","EGR3","DUSP10","CD86","RASGRP1","PTPRC","PTPN2","RUNX1","TGFB1","IL2RA","CCL19","SH3RF1","PRELID1","GATA3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_KILLING_OF_CELLS_OF_OTHER_ORGANISM","pval":0.07229,"padj":0.62163,"ES":0.98382,"NES":1.35332,"nMoreExtreme":3824,"size":5,"leadingEdge":["BCL2L11","BAD"]} {"pathway":"GO_DETERMINATION_OF_DIGESTIVE_TRACT_LEFT_RIGHT_ASYMMETRY","pval":0.07299,"padj":0.62434,"ES":0.98371,"NES":1.35317,"nMoreExtreme":3861,"size":5,"leadingEdge":["DNAAF1","MEGF8"]} {"pathway":"GO_EGG_ACTIVATION","pval":0.32205,"padj":0.86926,"ES":0.90721,"NES":1.35316,"nMoreExtreme":16183,"size":2,"leadingEdge":["PLCB1","ASTL"]} {"pathway":"GO_REGULATION_OF_NEURONAL_SYNAPTIC_PLASTICITY","pval":0.03886,"padj":0.50674,"ES":0.91353,"NES":1.35288,"nMoreExtreme":2664,"size":42,"leadingEdge":["EGR2","KCNJ10","AGT","RASGRF1","SLC8A2","SHISA7","ARC","MCTP1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CYTOLYSIS","pval":0.23671,"padj":0.82161,"ES":0.94995,"NES":1.35277,"nMoreExtreme":12319,"size":4,"leadingEdge":["P2RX7","LILRB1"]} {"pathway":"GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_OR_POLYSACCHARIDE_ANTIGEN_VIA_MHC_CLASS_II","pval":0.02762,"padj":0.41718,"ES":0.82763,"NES":1.35182,"nMoreExtreme":2140,"size":92,"leadingEdge":["HLA-DPA1","HLA-DMA","HLA-DMB","CD74","HLA-DOA","HLA-DRA","LAG3","HLA-DPB1","HLA-DRB1","HLA-DQB1","HLA-DRB5","HLA-DQB2","HLA-DOB","HLA-DQA1","CTSS","CTSL","IFI30"]} {"pathway":"GO_GOLGI_TO_PLASMA_MEMBRANE_PROTEIN_TRANSPORT","pval":0.02547,"padj":0.40216,"ES":0.93434,"NES":1.35177,"nMoreExtreme":1705,"size":36,"leadingEdge":["VAMP5","OPTN","AMN"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION","pval":0.04347,"padj":0.52235,"ES":0.90947,"NES":1.35174,"nMoreExtreme":2992,"size":43,"leadingEdge":["NLRC5","ACOD1","NMI","UBE2L6","CYLD","IFIH1","RELB","TNFAIP3","LILRA4","DDX58","LILRB1","DHX58","IKBKE","ISG15","TRIM25"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INNATE_IMMUNE_RESPONSE","pval":0.04348,"padj":0.52235,"ES":0.90947,"NES":1.35173,"nMoreExtreme":2993,"size":43,"leadingEdge":["SERPING1","HLA-F","CEACAM1","NLRC5","HLA-E","ACOD1","NMI","TRAFD1","HLA-G","SLAMF8","PARP14","TNFAIP3","SERPINB9","DUSP10","NR1H3","LILRB1","PTPN2","DHX58","A2M"]} {"pathway":"GO_APOPTOTIC_PROCESS_IN_BONE_MARROW_CELL","pval":0.07883,"padj":0.63581,"ES":0.9823,"NES":1.35124,"nMoreExtreme":4170,"size":5,"leadingEdge":["FLT3LG","FGFR2"]} {"pathway":"GO_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION","pval":0.03302,"padj":0.46522,"ES":0.84157,"NES":1.35097,"nMoreExtreme":2493,"size":78,"leadingEdge":["IRF1","SOCS1","CD274","IL12RB1","TBX21","HLA-E","RIPK2","IL27","CD80","ZC3H12A","JAK3","BCL6","IL12A","TNFRSF14","CD83","IRF4","EBI3","CD86","PTPRC","LILRB1","RUNX1","CCL19","SH3RF1","GATA3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_WNT_SIGNALING_PATHWAY","pval":0.01211,"padj":0.28135,"ES":0.78297,"NES":1.35043,"nMoreExtreme":1034,"size":174,"leadingEdge":["PSME2","PSMB9","KREMEN1","PSME1","DKK2","PSMB10","PSMB8","CYLD","TRABD2A","PTPRU","AMER1","PSMA4","PSMA2","PSMA5"]} {"pathway":"GO_LYTIC_VACUOLE_ORGANIZATION","pval":0.04243,"padj":0.52235,"ES":0.87344,"NES":1.34996,"nMoreExtreme":3043,"size":57,"leadingEdge":["P2RX7","LRRK2","RAB20","RAB39A","ARSB"]} {"pathway":"GO_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY","pval":0.02588,"padj":0.40506,"ES":0.81879,"NES":1.34941,"nMoreExtreme":2035,"size":100,"leadingEdge":["CALCOCO2","PLEK","SPTBN4","SCIN","TNF","UVRAG","ACTN2","SPTA1"]} {"pathway":"GO_REGULATION_OF_HEMOPOIESIS","pval":0.00131,"padj":0.07646,"ES":0.75083,"NES":1.34932,"nMoreExtreme":123,"size":382,"leadingEdge":["IRF1","PSME2","CD74","HLA-DOA","SOCS1","IL12RB1","PSMB9","IL15","TBX21","CEACAM1","PSME1","STAT1","CTLA4","PSMB10","TMEM176A","TMEM176B","RIPK2","IL27","PSMB8","LILRB3","FLT3LG","CD80","B2M","ZC3H12A","JAK3","CYLD","SCIN","IRF7","BTN2A2","HLA-G","SLAMF8","BCL6","LYN","CSF1","NR4A3","IL7","CD83","IRF4","TLR3","LILRB4","EGR3","NOTCH2","TNF","PSMA4","PSMA2","DUSP10","CD86","RASGRP1","MOV10","PTPRC","LILRB1","STAT3","PTPN2","RUNX1","TGFB1","OCSTAMP","IL2RA","CCL19","C1QC","PSMA5","GP1BA","NFKBIA","ISG15","SH3RF1","GAS6","CCL3","FOXC1","PRELID1","TCIM","GATA3","NFE2L2","PPARGC1B"]} {"pathway":"GO_MESENCHYMAL_STEM_CELL_MAINTENANCE_INVOLVED_IN_NEPHRON_MORPHOGENESIS","pval":0.332,"padj":0.87332,"ES":0.90463,"NES":1.34931,"nMoreExtreme":16683,"size":2,"leadingEdge":["HNF1B","PAX8"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SOMATIC_STEM_CELL_POPULATION_MAINTENANCE","pval":0.332,"padj":0.87332,"ES":0.90463,"NES":1.34931,"nMoreExtreme":16683,"size":2,"leadingEdge":["HNF1B","PAX8"]} {"pathway":"GO_REGULATION_OF_IRON_ION_TRANSPORT","pval":0.08731,"padj":0.65537,"ES":0.98056,"NES":1.34884,"nMoreExtreme":4619,"size":5,"leadingEdge":["B2M","HFE"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_GAMMA_RADIATION","pval":0.00871,"padj":0.24715,"ES":0.97587,"NES":1.34797,"nMoreExtreme":559,"size":27,"leadingEdge":["TMEM109","KDM1A"]} {"pathway":"GO_POSITIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS","pval":0.01281,"padj":0.29031,"ES":0.78116,"NES":1.34731,"nMoreExtreme":1094,"size":174,"leadingEdge":["HLA-DMB","CD40","CD74","P2RX7","IL12RB1","LAG3","TBX21","NOD2","HLA-F","HLA-B","HLA-E","HLA-A","HLA-C","RIPK2","CD80","B2M","C3","SLAMF6","RSAD2","DDX60","HLA-G","LYN","IL12A","LTA","NR4A3","TNFRSF14","IL6","SEMA7A","TNF","CD226","CD86","RASGRP1","PTPRC","PTAFR","DDX58","LILRB1","DHX58","TGFB1","CCL19"]} {"pathway":"GO_REGULATION_OF_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORT","pval":0.25743,"padj":0.82758,"ES":0.94609,"NES":1.34728,"nMoreExtreme":13397,"size":4,"leadingEdge":["PTAFR","ANO9"]} {"pathway":"GO_TOLERANCE_INDUCTION_TO_SELF_ANTIGEN","pval":0.25743,"padj":0.82758,"ES":0.94607,"NES":1.34725,"nMoreExtreme":13397,"size":4,"leadingEdge":["LYN","TGFB1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_NEUROBLAST_PROLIFERATION","pval":0.2576,"padj":0.82758,"ES":0.94602,"NES":1.34717,"nMoreExtreme":13406,"size":4,"leadingEdge":["TGFB1","CTNNA1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_EXTRACELLULAR_MATRIX_DISASSEMBLY","pval":0.2576,"padj":0.82758,"ES":0.94602,"NES":1.34717,"nMoreExtreme":13406,"size":4,"leadingEdge":["TGFB1","FAP"]} {"pathway":"GO_REGULATION_OF_BRANCHING_INVOLVED_IN_MAMMARY_GLAND_DUCT_MORPHOGENESIS","pval":0.2576,"padj":0.82758,"ES":0.94602,"NES":1.34717,"nMoreExtreme":13406,"size":4,"leadingEdge":["TGFB1","WNT5A"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PLATELET_ACTIVATION","pval":0.25791,"padj":0.82758,"ES":0.94599,"NES":1.34712,"nMoreExtreme":13422,"size":4,"leadingEdge":["PLEK","TLR4"]} {"pathway":"GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_HYPOXIA","pval":0.03743,"padj":0.49711,"ES":0.84641,"NES":1.34682,"nMoreExtreme":2792,"size":72,"leadingEdge":["PSME2","PSMB9","PSME1","PSMB10","PSMB8","BACH1","PSMA4","PSMA2","PSMA5","NFE2L2"]} {"pathway":"GO_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS","pval":0.00734,"padj":0.22464,"ES":0.76763,"NES":1.34659,"nMoreExtreme":651,"size":228,"leadingEdge":["PSME2","LRRK2","LAMP3","ATP13A2","PSME1","NUB1","PML","RNF19B","PYHIN1","AMER1","TNFAIP3","EDEM1","RNF144B","GCLC","CTSC","NFE2L2","IL33","HERPUD1","NUPR1","RNF19A"]} {"pathway":"GO_REGULATION_OF_ACTIN_FILAMENT_BASED_MOVEMENT","pval":0.0302,"padj":0.43469,"ES":0.93072,"NES":1.34653,"nMoreExtreme":2022,"size":36,"leadingEdge":["PDE4B","KCNJ2","CAMK2D","SRI","ANK2","RNF207"]} {"pathway":"GO_URINARY_TRACT_SMOOTH_MUSCLE_CONTRACTION","pval":0.26269,"padj":0.83229,"ES":0.94506,"NES":1.34581,"nMoreExtreme":13671,"size":4,"leadingEdge":["KCNMA1","PLA2G6"]} {"pathway":"GO_MICTURITION","pval":0.26269,"padj":0.83229,"ES":0.94506,"NES":1.34581,"nMoreExtreme":13671,"size":4,"leadingEdge":["KCNMA1","CHRNA3"]} {"pathway":"GO_REGULATION_OF_OSTEOCLAST_PROLIFERATION","pval":0.26313,"padj":0.83229,"ES":0.94495,"NES":1.34565,"nMoreExtreme":13694,"size":4,"leadingEdge":["FLT3LG","TNFAIP3","OCSTAMP"]} {"pathway":"GO_ENDOPLASMIC_RETICULUM_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT","pval":0.01137,"padj":0.27533,"ES":0.77616,"NES":1.34557,"nMoreExtreme":982,"size":187,"leadingEdge":["LRRK2","SPTBN4","ANK2","TICAM2","CTSZ","CTSC","GAS6","NAPA","LMF1","SPTA1","STX17","RAB43"]} {"pathway":"GO_MANNOSYLATION","pval":0.02083,"padj":0.36541,"ES":0.94801,"NES":1.34546,"nMoreExtreme":1369,"size":32,"leadingEdge":["TMTC1","TMTC2","DPM1"]} {"pathway":"GO_ALPHA_BETA_T_CELL_ACTIVATION","pval":0.02441,"padj":0.39639,"ES":0.80613,"NES":1.34475,"nMoreExtreme":1959,"size":114,"leadingEdge":["IRF1","SOCS1","CD274","IL12RB1","ITK","IL15","TBX21","HLA-E","RIPK2","IL27","CD80","SLAMF6","ZC3H12A","JAK3","RSAD2","PTGER4","RELB","BCL6","IL12A","TNFRSF14","CD83","IRF4","IL6","EBI3","CD86","GPR18","PTPRC","LILRB1","STAT3","RUNX1","SEMA4A","CCL19","SH3RF1"]} {"pathway":"GO_UREA_TRANSPORT","pval":0.34271,"padj":0.87929,"ES":0.90154,"NES":1.3447,"nMoreExtreme":17221,"size":2,"leadingEdge":["AQP9","AQP3"]} {"pathway":"GO_REGULATION_OF_HEART_INDUCTION","pval":0.26746,"padj":0.83635,"ES":0.94416,"NES":1.34453,"nMoreExtreme":13919,"size":4,"leadingEdge":["ROBO1","DKK1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_HEART_INDUCTION","pval":0.26746,"padj":0.83635,"ES":0.94416,"NES":1.34453,"nMoreExtreme":13919,"size":4,"leadingEdge":["ROBO1","DKK1"]} {"pathway":"GO_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY","pval":0.01498,"padj":0.31325,"ES":0.78216,"NES":1.34423,"nMoreExtreme":1271,"size":165,"leadingEdge":["IRF1","TIFA","NOD2","ACOD1","RIPK2","TLR8","CD300LF","TLR10","CTSS","CYLD","IRF7","RSAD2","IFIH1","LILRA2","DDX60","LYN","TLR7","TICAM2","TANK","CTSL","IRF4","TNFAIP3","LILRA4","BIRC3","MYD88","TLR3","CLEC4E","PIK3AP1","DDX58","NR1H3","DHX58","WDFY1","IKBKE","NFKBIA","TREML4","OTUD4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SARCOMERE_ORGANIZATION","pval":0.3884,"padj":0.89286,"ES":0.91223,"NES":1.34398,"nMoreExtreme":19855,"size":3,"leadingEdge":["EDN1","PROX1"]} {"pathway":"GO_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION","pval":0.05077,"padj":0.55505,"ES":0.88438,"NES":1.3435,"nMoreExtreme":3570,"size":50,"leadingEdge":["SOCS1","CD274","IL12RB1","TBX21","RIPK2","IL27","CD80","ZC3H12A","JAK3","BCL6","CD83","IRF4","CD86","RUNX1","CCL19","SH3RF1","GATA3"]} {"pathway":"GO_ASPARTATE_METABOLIC_PROCESS","pval":0.38991,"padj":0.8943,"ES":0.91187,"NES":1.34345,"nMoreExtreme":19932,"size":3,"leadingEdge":["ASS1","GOT1"]} {"pathway":"GO_INTERLEUKIN_12_PRODUCTION","pval":0.05339,"padj":0.56014,"ES":0.89424,"NES":1.34327,"nMoreExtreme":3715,"size":46,"leadingEdge":["IRF1","IDO1","CD40","RIPK2","TLR8","MEFV","JAK3","SLAMF1","HLA-G","TLR3","LTB","CD47","LILRB1","CCL19","IRF5","PLCB1","LILRA5","IRF8","TLR4"]} {"pathway":"GO_CARDIAC_MUSCLE_TISSUE_REGENERATION","pval":0.2738,"padj":0.83769,"ES":0.94298,"NES":1.34285,"nMoreExtreme":14249,"size":4,"leadingEdge":["CDKN1A","CDKN1B"]} {"pathway":"GO_INNATE_IMMUNE_RESPONSE_ACTIVATING_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY","pval":0.03047,"padj":0.43771,"ES":0.81912,"NES":1.34238,"nMoreExtreme":2373,"size":95,"leadingEdge":["PSME2","PSMB9","PSME1","PSMB10","PSMB8","CLEC6A","MUC1","CLEC10A","ICAM2","LILRA2","RELB","LYN","CLEC4D","CLEC4E","PSMA4","PSMA2","CUL1","PAK1","SRC","PSMA5"]} {"pathway":"GO_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION","pval":0.00003,"padj":0.00636,"ES":0.73506,"NES":1.34222,"nMoreExtreme":2,"size":795,"leadingEdge":["UBD","PSME2","SOCS1","LRRK2","PSMB9","FBXO6","NOD2","PSME1","EGR2","NMI","TRIM17","PSMB10","NUB1","IFI27","RIPK2","LONRF1","UBE2L6","PSMB8","JADE2","TRIM22","RNF19B","PARP10","TRIM69","FEM1C","IFIH1","DTX3L","FAM107A","CISH","TRIM31","DYSF","ASB2","AMER1","TNFAIP3","RNF144B","BIRC3","WSB1","RNF24","PSMA4","PSMA2","SPOPL","RBCK1","CUL1","TRIM72","UBE2A","ATG3","VCPIP1","SOCS3","TRIM71","TRIM9","GCLC","PSMA5","TRIM21","ZNRF2","UBE2Z","ADGRB1","ISG15","SH3RF1","NEURL3","TRIM25","PCGF5","BIRC7","NFE2L2","HERPUD1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS","pval":0.05319,"padj":0.56014,"ES":0.88823,"NES":1.34217,"nMoreExtreme":3723,"size":48,"leadingEdge":["NLRC5","PADI2","KLF4","STAP1","CARD16","IL1RN","CCL5","PARP14","IL6","PTPRC","NR1H3","PTPN2","ROBO1","OTUD4","GAS6","IL1R2","SLIT2"]} {"pathway":"GO_REGULATION_OF_NEURONAL_ACTION_POTENTIAL","pval":0.39908,"padj":0.89503,"ES":0.90996,"NES":1.34063,"nMoreExtreme":20401,"size":3,"leadingEdge":["GPR35","FMR1"]} {"pathway":"GO_MULTI_ORGANISM_CELLULAR_PROCESS","pval":0.03732,"padj":0.49711,"ES":0.92643,"NES":1.34033,"nMoreExtreme":2499,"size":36,"leadingEdge":["IRF7","IFIH1","DDX60","BIRC3","CCR5","DDX58","DHX58","GAS6","TSPAN6"]} {"pathway":"GO_REGULATION_OF_PROTEOLYSIS","pval":0.00031,"padj":0.02801,"ES":0.73822,"NES":1.34015,"nMoreExtreme":29,"size":558,"leadingEdge":["PSME2","AIM2","C4A","LRRK2","PSMB9","GSAP","C4B","SERPING1","LAMP3","HGF","TNFSF10","ATP13A2","PSME1","JAK2","NUB1","AGT","RIPK2","PZP","FAS","PSMB8","KLF4","BCL2L11","PML","RNF19B","C3","MEFV","ZC3H12A","CASP4","CARD17","CARD16","PMAIP1","LYN","PYHIN1","CHAC1","TANK","EDEM1","RNF144B","BIRC3","CASP10","CTSZ","TNF","HPN","SERPINB9","SPOPL","CASP5","F3","STAT3","GCLC","SRC","A2M","ROBO1","AKIRIN2","TRIM21","CTSC","UBE2Z","IFI6","SH3RF1","OTUD4","PLGRKT","PTGS2","GAS6","PARL","PRELID1","CFLAR","BIRC7","CASP1","NKX3-1","NFE2L2","IL33","SERPINB1","SPINK1","HERPUD1","BBC3","IL1R2","SMAD3","HMSD","BAK1","NUPR1","RNF19A","NGF","TNFAIP8"]} {"pathway":"GO_COFACTOR_BIOSYNTHETIC_PROCESS","pval":0.01268,"padj":0.28914,"ES":0.77181,"NES":1.33901,"nMoreExtreme":1097,"size":189,"leadingEdge":["IDO1","GCH1","IDO2","ACSL1","CYP1A1","PARP10","ALAS1","CNDP2","CTNS","GGT5","CHAC1","PARP9","KYNU","ACSL5","ELOVL7","KMO","STAT3","GCLC","ACSS1","NAMPT","MMAA","PTGS2","NFE2L2","NADK","SPTA1","RFK"]} {"pathway":"GO_SPERMIDINE_METABOLIC_PROCESS","pval":0.12173,"padj":0.70864,"ES":0.97337,"NES":1.33895,"nMoreExtreme":6440,"size":5,"leadingEdge":["SAT1","DHPS"]} {"pathway":"GO_L_LYSINE_TRANSPORT","pval":0.29113,"padj":0.85125,"ES":0.93978,"NES":1.33829,"nMoreExtreme":15151,"size":4,"leadingEdge":["AGT","SLC7A2"]} {"pathway":"GO_AORTA_SMOOTH_MUSCLE_TISSUE_MORPHOGENESIS","pval":0.4064,"padj":0.89503,"ES":0.90833,"NES":1.33823,"nMoreExtreme":20775,"size":3,"leadingEdge":["PROX1","MYLK"]} {"pathway":"GO_ORNITHINE_TRANSPORT","pval":0.29136,"padj":0.85125,"ES":0.93973,"NES":1.33821,"nMoreExtreme":15163,"size":4,"leadingEdge":["SLC7A2","SLC25A15"]} {"pathway":"GO_REGULATION_OF_T_CELL_RECEPTOR_SIGNALING_PATHWAY","pval":0.02403,"padj":0.39285,"ES":0.94762,"NES":1.33767,"nMoreExtreme":1572,"size":31,"leadingEdge":["GBP1","CEACAM1","CYLD","BTN2A2","LILRB4","CD226","PTPN2"]} {"pathway":"GO_ORGANIC_CYCLIC_COMPOUND_CATABOLIC_PROCESS","pval":0.00038,"padj":0.03146,"ES":0.73738,"NES":1.33757,"nMoreExtreme":36,"size":538,"leadingEdge":["IDO1","PSME2","PSMB9","PDE4B","PSME1","ISG20","IDO2","PSMB10","DPYS","PSMB8","XRN1","TYMP","CYP1A1","HSD3B7","SIDT2","SCARF1","APOBEC3D","ENPP4","SAMD4A","APOBEC3A","APOBEC3G","ZC3H12A","GTPBP1","OAS2","KYNU","MYD88","APOBEC3F","PSMA4","PSMA2","HELZ2","MOV10","CYP27B1","KMO","TRIM71","HPD","PSMA5","ADA2"]} {"pathway":"GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY","pval":0.054,"padj":0.56056,"ES":0.87771,"NES":1.33741,"nMoreExtreme":3814,"size":51,"leadingEdge":["CYLD","CASP4","CARD16","TNFAIP3","BIRC3","TNF","RBCK1","PTPN2","SPPL2A","GAS6","CASP1","TRAF1"]} {"pathway":"GO_RETINA_HOMEOSTASIS","pval":0.04861,"padj":0.5476,"ES":0.91659,"NES":1.33736,"nMoreExtreme":3286,"size":38,"leadingEdge":["B2M","PRDX1","ESRRB","PROM1"]} {"pathway":"GO_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY","pval":0.02026,"padj":0.36159,"ES":0.78571,"NES":1.33715,"nMoreExtreme":1686,"size":145,"leadingEdge":["PSME2","AIM2","CD40","PSMB9","PSME1","STAT1","JAK2","PSMB10","TNFSF13B","PSMB8","TNFSF18","CYLD","CASP4","CARD16","LTA","TNFRSF14","TNFAIP3","CD70","BIRC3","LTB","TNF","PSMA4","PSMA2","RBCK1","PTPN2","PSMA5","NFKBIA","SPPL2A","GAS6","CASP1","TNFRSF6B","TRAF1"]} {"pathway":"GO_ACETATE_ESTER_TRANSPORT","pval":0.41143,"padj":0.89503,"ES":0.90732,"NES":1.33674,"nMoreExtreme":21032,"size":3,"leadingEdge":["SLC22A1","ADORA2A","CHRNA3"]} {"pathway":"GO_RESPONSE_TO_ERYTHROPOIETIN","pval":0.13034,"padj":0.72544,"ES":0.97174,"NES":1.33671,"nMoreExtreme":6896,"size":5,"leadingEdge":["CD40","MT2A","HAMP"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_BLOOD_CIRCULATION","pval":0.00961,"padj":0.25147,"ES":0.97953,"NES":1.3367,"nMoreExtreme":611,"size":25,"leadingEdge":["JAK2","SPTBN4","SRI","ZC3H12A","PIK3CG"]} {"pathway":"GO_HEAT_ACCLIMATION","pval":0.13101,"padj":0.72691,"ES":0.97163,"NES":1.33655,"nMoreExtreme":6931,"size":5,"leadingEdge":["HSBP1L1","RBBP7"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_FERTILIZATION","pval":0.41215,"padj":0.89503,"ES":0.90715,"NES":1.33649,"nMoreExtreme":21069,"size":3,"leadingEdge":["ASTL","OVGP1"]} {"pathway":"GO_REGULATION_OF_BINDING_OF_SPERM_TO_ZONA_PELLUCIDA","pval":0.41215,"padj":0.89503,"ES":0.90715,"NES":1.33649,"nMoreExtreme":21069,"size":3,"leadingEdge":["ASTL","OVGP1"]} {"pathway":"GO_REGULATION_OF_SYNAPTIC_GROWTH_AT_NEUROMUSCULAR_JUNCTION","pval":0.29849,"padj":0.85717,"ES":0.93852,"NES":1.33649,"nMoreExtreme":15534,"size":4,"leadingEdge":["COLQ","SIX1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_RECEPTOR_CATABOLIC_PROCESS","pval":0.29904,"padj":0.85717,"ES":0.93838,"NES":1.33629,"nMoreExtreme":15563,"size":4,"leadingEdge":["DTX3L","PTPN1","ITCH"]} {"pathway":"GO_POTASSIUM_ION_TRANSPORT","pval":0.02112,"padj":0.36735,"ES":0.78735,"NES":1.33628,"nMoreExtreme":1749,"size":140,"leadingEdge":["ATP1B2","KCNJ10","SLC12A3","KCNJ2","KCNJ15","ANK2","KCNE5","RNF207","HPN","SLC12A7","KCNE1","P2RY12","KCNMA1","ACTN2","MIR212","KCNE1B","KCNMB1","SLC9A4"]} {"pathway":"GO_T_TUBULE_ORGANIZATION","pval":0.13235,"padj":0.72944,"ES":0.97135,"NES":1.33617,"nMoreExtreme":7002,"size":5,"leadingEdge":["MYOF","ANK2","DYSF"]} {"pathway":"GO_PEPTIDE_SECRETION","pval":0.00098,"padj":0.06189,"ES":0.73887,"NES":1.3352,"nMoreExtreme":93,"size":457,"leadingEdge":["GBP5","AIM2","CD40","GBP1","CD74","P2RX7","SOCS1","CD274","LRRK2","CD38","NOD2","BTN3A2","PLEK","CLEC9A","ATP13A2","BTN3A1","HLA-E","BANK1","HCAR2","JAK2","SUCNR1","AGT","RIPK2","TLR8","TNFSF13B","MCOLN2","SIDT2","CLEC6A","GSDMD","PML","SRI","S100A13","TLR10","ZC3H12A","CARD17","CARD16","RSAD2","BTN2A2","EDN1","VEGFC","IFIH1","LILRA2","IL1RN","COMP","EXOC3L1","DYSF","PTGER4","CCL5","LYN","GLUL","TNFRSF14","TNFAIP3","IL6","CLEC4E","TNF","VGF","RASGRP1","SMPD3","CCL1","LCP2","CHI3L1","DDX58","NR1H3","LILRB1","MAFA","SRC","TGFB1","CCL19","UCP2","RHBDF2","GAS6","CCL3","CX3CL1","GATA3","CASP1","SRCIN1","IL33"]} {"pathway":"GO_SULFUR_AMINO_ACID_TRANSPORT","pval":0.13639,"padj":0.73298,"ES":0.97062,"NES":1.33516,"nMoreExtreme":7216,"size":5,"leadingEdge":["CTNS","NFE2L1"]} {"pathway":"GO_TYROSINE_PHOSPHORYLATION_OF_STAT_PROTEIN","pval":0.05139,"padj":0.55686,"ES":0.86145,"NES":1.33501,"nMoreExtreme":3700,"size":58,"leadingEdge":["IL31RA","CD40","SOCS1","IL15","JAK2","TNFSF18","JAK3","STAP2","CCL5","LYN","IL12A","PARP14","PARP9","IL6","TNF","SOCS3","STAT3","PTPN2"]} {"pathway":"GO_REGULATION_OF_INTERLEUKIN_2_SECRETION","pval":0.00628,"padj":0.2084,"ES":0.99831,"NES":1.33492,"nMoreExtreme":336,"size":6,"leadingEdge":["GBP1","EZR"]} {"pathway":"GO_POLYNUCLEOTIDE_DEPHOSPHORYLATION","pval":0.13794,"padj":0.73306,"ES":0.97028,"NES":1.3347,"nMoreExtreme":7298,"size":5,"leadingEdge":["POLB","PNKP"]} {"pathway":"GO_LYMPHOCYTE_DIFFERENTIATION","pval":0.00582,"padj":0.19815,"ES":0.7527,"NES":1.33431,"nMoreExtreme":529,"size":278,"leadingEdge":["IRF1","CD74","HLA-DOA","SOCS1","IL12RB1","ITK","IL15","TBX21","CTLA4","RIPK2","IL27","VCAM1","FLT3LG","CD80","B2M","SLAMF6","ZC3H12A","JAK3","CYLD","RSAD2","BTN2A2","HLA-G","SLAMF8","PTGER4","RELB","BCL6","IL7","CD83","IRF4","IL6","CLEC4D","CLEC4E","LILRB4","EGR3","NOTCH2","DUSP10","CD86","GPR18","RASGRP1","PTPRC","RHOH","TPD52","KLF6","STAT3","PTPN2","RUNX1","TGFB1","SEMA4A","IL2RA","CCL19","CCR6","LIG4","SH3RF1","GAS6","PRELID1","GATA3"]} {"pathway":"GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS","pval":0.05281,"padj":0.55951,"ES":0.86543,"NES":1.33419,"nMoreExtreme":3777,"size":56,"leadingEdge":["LRRK2","BCL2L11","PML","CASP4","PMAIP1","CHAC1","PTPN2","PTPN1","GRINA","HERPUD1","BBC3","BAK1"]} {"pathway":"GO_LEUKOTRIENE_D4_BIOSYNTHETIC_PROCESS","pval":0.14083,"padj":0.73814,"ES":0.96972,"NES":1.33393,"nMoreExtreme":7451,"size":5,"leadingEdge":["GGT5","GGT1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_HISTONE_DEACETYLASE_ACTIVITY","pval":0.0095,"padj":0.25145,"ES":0.99753,"NES":1.33387,"nMoreExtreme":509,"size":6,"leadingEdge":["LRRK2","PRKD2"]} {"pathway":"GO_UBIQUITIN_INDEPENDENT_PROTEIN_CATABOLIC_PROCESS_VIA_THE_MULTIVESICULAR_BODY_SORTING_PATHWAY","pval":0.1417,"padj":0.73885,"ES":0.96955,"NES":1.3337,"nMoreExtreme":7497,"size":5,"leadingEdge":["CHMP4C","CHMP4B"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION","pval":0.05004,"padj":0.55243,"ES":0.91787,"NES":1.33358,"nMoreExtreme":3365,"size":37,"leadingEdge":["CEACAM1","LILRB3","LYN","TLR3","LILRB4","LILRB1","PTPN2","C1QC","CCL3","TLR4"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY","pval":0.05391,"padj":0.56056,"ES":0.91394,"NES":1.33349,"nMoreExtreme":3644,"size":38,"leadingEdge":["TBX21","HLA-F","CEACAM1","HLA-E","JAK3","HLA-G","BCL6","PARP3","SERPINB9","PTPRC","LILRB1"]} {"pathway":"GO_B_CELL_MEDIATED_IMMUNITY","pval":0.03674,"padj":0.49381,"ES":0.82034,"NES":1.33347,"nMoreExtreme":2825,"size":88,"leadingEdge":["CD40","C4A","CD74","C4B","SERPING1","TBX21","C1QB","HLA-DQB1","HLA-E","TLR8","C2","C3","IRF7","C1S","C1RL","C1R","HLA-G","GCNT3","BCL6","LTA","PARP3","TNF","CD226","PTPRC","NBN","TGFB1","CCR6","C1QC","LIG4"]} {"pathway":"GO_MULTI_ORGANISM_CELLULAR_LOCALIZATION","pval":0.14308,"padj":0.74198,"ES":0.96927,"NES":1.33331,"nMoreExtreme":7570,"size":5,"leadingEdge":["DYNLT1","RAB7A"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INTERLEUKIN_23_PRODUCTION","pval":0.42363,"padj":0.89613,"ES":0.90492,"NES":1.33321,"nMoreExtreme":21656,"size":3,"leadingEdge":["MYD88","IL17RA"]} {"pathway":"GO_NK_T_CELL_DIFFERENTIATION","pval":0.01211,"padj":0.28135,"ES":0.99691,"NES":1.33304,"nMoreExtreme":649,"size":6,"leadingEdge":["ITK","PRDM1"]} {"pathway":"GO_REGULATION_OF_ISOTYPE_SWITCHING_TO_IGE_ISOTYPES","pval":0.14471,"padj":0.74547,"ES":0.96899,"NES":1.33292,"nMoreExtreme":7656,"size":5,"leadingEdge":["BCL6","TNFSF4"]} {"pathway":"GO_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION","pval":0.04348,"padj":0.52235,"ES":0.83388,"NES":1.33288,"nMoreExtreme":3264,"size":75,"leadingEdge":["SOCS1","CD274","IL12RB1","TBX21","RIPK2","IL27","CD80","SLAMF6","ZC3H12A","JAK3","RSAD2","PTGER4","RELB","BCL6","CD83","IRF4","IL6","CD86","STAT3","RUNX1","SEMA4A","CCL19","SH3RF1","GATA3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_APOPTOTIC_PROCESS_INVOLVED_IN_DEVELOPMENT","pval":0.42463,"padj":0.89678,"ES":0.90468,"NES":1.33285,"nMoreExtreme":21707,"size":3,"leadingEdge":["FOXC1","HNF1B"]} {"pathway":"GO_REGULATION_OF_RECEPTOR_SIGNALING_PATHWAY_VIA_STAT","pval":0.03575,"padj":0.48389,"ES":0.81496,"NES":1.33274,"nMoreExtreme":2776,"size":93,"leadingEdge":["IL31RA","CD40","SOCS1","IL15","JAK2","AGT","TNFSF18","JAK3","STAP2","CCL5","LYN","IL12A","PARP14","PARP9","IL6","TNF","PTPRC","SOCS3","SH2B2","STAT3","PTPN2"]} {"pathway":"GO_ORGANELLE_TRANSPORT_ALONG_MICROTUBULE","pval":0.04447,"padj":0.5276,"ES":0.83464,"NES":1.33243,"nMoreExtreme":3333,"size":74,"leadingEdge":["DTNBP1","RASGRP1","MAP2","TRIM46","HAP1","PAFAH1B1"]} {"pathway":"GO_ALPHA_BETA_T_CELL_DIFFERENTIATION","pval":0.03867,"padj":0.50613,"ES":0.82223,"NES":1.33213,"nMoreExtreme":2960,"size":85,"leadingEdge":["IRF1","SOCS1","IL12RB1","ITK","TBX21","RIPK2","IL27","CD80","SLAMF6","ZC3H12A","JAK3","RSAD2","PTGER4","RELB","BCL6","CD83","IRF4","IL6","CD86","GPR18","STAT3","RUNX1","SEMA4A","CCL19","SH3RF1","GATA3"]} {"pathway":"GO_INTERLEUKIN_1_ALPHA_SECRETION","pval":0.31605,"padj":0.86619,"ES":0.93537,"NES":1.33201,"nMoreExtreme":16448,"size":4,"leadingEdge":["P2RX7","S100A13","IL1R2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_OSMOTIC_STRESS","pval":0.31641,"padj":0.86626,"ES":0.93529,"NES":1.33189,"nMoreExtreme":16467,"size":4,"leadingEdge":["PTGS2","YBX3"]} {"pathway":"GO_ACTIVATION_OF_PHOSPHOLIPASE_D_ACTIVITY","pval":0.14926,"padj":0.75097,"ES":0.9682,"NES":1.33184,"nMoreExtreme":7897,"size":5,"leadingEdge":["CCL5","PRKCZ"]} {"pathway":"GO_PRODUCTION_OF_SMALL_RNA_INVOLVED_IN_GENE_SILENCING_BY_RNA","pval":0.05918,"padj":0.58367,"ES":0.87655,"NES":1.33161,"nMoreExtreme":4162,"size":50,"leadingEdge":["ZC3H12A","TRIM71","TGFB1","ADAR","LIN28A","SMAD3","PUM2"]} {"pathway":"GO_CAMP_CATABOLIC_PROCESS","pval":0.01861,"padj":0.35375,"ES":0.99545,"NES":1.33109,"nMoreExtreme":998,"size":6,"leadingEdge":["PDE4B","PDE4A"]} {"pathway":"GO_MONOCYTE_AGGREGATION","pval":0.3196,"padj":0.86901,"ES":0.93473,"NES":1.33109,"nMoreExtreme":16633,"size":4,"leadingEdge":["NR4A3","HAS2","CD44"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_IMPORT","pval":0.04606,"padj":0.53818,"ES":0.92409,"NES":1.33097,"nMoreExtreme":3069,"size":35,"leadingEdge":["ZC3H12A","TGFB1","PTGS2","SMAD3","CDH1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SENSORY_PERCEPTION_OF_PAIN","pval":0.32022,"padj":0.86901,"ES":0.93462,"NES":1.33094,"nMoreExtreme":16665,"size":4,"leadingEdge":["PTAFR","ATPSCKMT"]} {"pathway":"GO_INTERLEUKIN_1_SECRETION","pval":0.06187,"padj":0.59289,"ES":0.88332,"NES":1.33094,"nMoreExtreme":4317,"size":47,"leadingEdge":["GBP5","AIM2","P2RX7","NOD2","RIPK2","TLR8","GSDMD","PML","S100A13","ZC3H12A","CARD17","CARD16","LILRA2","TNFAIP3","CCL19","GAS6","CCL3","CASP1","IL1R2","LILRA5","TLR4"]} {"pathway":"GO_T_CELL_MEDIATED_IMMUNITY","pval":0.03766,"padj":0.49791,"ES":0.81669,"NES":1.33065,"nMoreExtreme":2906,"size":90,"leadingEdge":["IL31RA","P2RX7","IL12RB1","TBX21","HLA-F","CEACAM1","BTN3A2","HLA-B","HLA-E","HLA-A","HLA-C","BTN3A3","ICAM1","B2M","RSAD2","HLA-G","IL12A","DENND1B","IL6","PTPRC","LILRB1","CTSC"]} {"pathway":"GO_INTERFERON_GAMMA_PRODUCTION","pval":0.03922,"padj":0.50871,"ES":0.82016,"NES":1.33018,"nMoreExtreme":3007,"size":86,"leadingEdge":["HLA-DPA1","CD274","IL12RB1","ITK","PDCD1LG2","PDE4B","HLA-DPB1","BTN3A2","BTN3A1","RIPK2","TLR8","IL27","SLAMF6","ZC3H12A","IL12RB2","IL12A","TLR7","LTA","TLR3","TNF","EBI3","CD226","CD47","RASGRP1","LILRB1","ISG15","GAS6","GATA3","IL33"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_NATURAL_KILLER_CELL_ACTIVATION","pval":0.02208,"padj":0.376,"ES":0.99466,"NES":1.33004,"nMoreExtreme":1184,"size":6,"leadingEdge":["HLA-F","PIBF1"]} {"pathway":"GO_MAST_CELL_MEDIATED_IMMUNITY","pval":0.06279,"padj":0.59455,"ES":0.90747,"NES":1.3299,"nMoreExtreme":4264,"size":39,"leadingEdge":["S100A13","LYN","NR4A3","SERPINB9","RASGRP1","FCER1G","CD84","FGR"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_T_CELL_DIFFERENTIATION","pval":0.04344,"padj":0.52235,"ES":0.92761,"NES":1.32984,"nMoreExtreme":2883,"size":34,"leadingEdge":["IRF1","CD74","SOCS1","TBX21","CTLA4","ZC3H12A","JAK3","BCL6","PTPN2","RUNX1"]} {"pathway":"GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE","pval":0.05795,"padj":0.57725,"ES":0.86828,"NES":1.32968,"nMoreExtreme":4114,"size":53,"leadingEdge":["VAMP5","OPTN","AMN","RILPL1","ARHGAP44"]} {"pathway":"GO_RECEPTOR_MEDIATED_VIRION_ATTACHMENT_TO_HOST_CELL","pval":0.32767,"padj":0.87134,"ES":0.93338,"NES":1.32917,"nMoreExtreme":17053,"size":4,"leadingEdge":["ICAM1","GAS6"]} {"pathway":"GO_MEMBRANE_FUSION","pval":0.02779,"padj":0.41718,"ES":0.79081,"NES":1.32905,"nMoreExtreme":2259,"size":124,"leadingEdge":["TAP2","TAP1","STX11","SAMD9L","TAPBP","PRRT2","RAB20","DYSF","CCR5","MX1","VCPIP1","TRIM9","UVRAG","SAMD9","GAS6","NAPA","STX3","RAB39A","STX17"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT_PROTEIN","pval":0.06409,"padj":0.59632,"ES":0.88468,"NES":1.32891,"nMoreExtreme":4460,"size":46,"leadingEdge":["IL31RA","CD40","IL15","JAK2","TNFSF18","STAP2","CCL5","LYN","IL12A","PARP14","PARP9","IL6","TNF","SOCS3","STAT3"]} {"pathway":"GO_BETA_CATENIN_TCF_COMPLEX_ASSEMBLY","pval":0.02572,"padj":0.40342,"ES":0.95112,"NES":1.32881,"nMoreExtreme":1668,"size":29,"leadingEdge":["TCF7L1","CREBBP"]} {"pathway":"GO_LIPID_STORAGE","pval":0.05629,"padj":0.56995,"ES":0.86188,"NES":1.32872,"nMoreExtreme":4026,"size":56,"leadingEdge":["SOAT1","C3","ZC3H12A","TTC39B","DGAT2","DYSF","IL6","TNF","NR1H3","PTPN2","IKBKE","GM2A","NFKBIA"]} {"pathway":"GO_TERMINATION_OF_RNA_POLYMERASE_I_TRANSCRIPTION","pval":0.03223,"padj":0.45943,"ES":0.94127,"NES":1.3287,"nMoreExtreme":2109,"size":31,"leadingEdge":["TAF1A","MNAT1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_LONG_TERM_SYNAPTIC_DEPRESSION","pval":0.43797,"padj":0.90126,"ES":0.9017,"NES":1.32847,"nMoreExtreme":22389,"size":3,"leadingEdge":["LILRB2","KCNB1"]} {"pathway":"GO_COMMON_MYELOID_PROGENITOR_CELL_PROLIFERATION","pval":0.16223,"padj":0.76748,"ES":0.96573,"NES":1.32844,"nMoreExtreme":8583,"size":5,"leadingEdge":["CEACAM1","NR4A3","GSTP1"]} {"pathway":"GO_NEURON_DEATH_IN_RESPONSE_TO_HYDROGEN_PEROXIDE","pval":0.16253,"padj":0.7677,"ES":0.96568,"NES":1.32836,"nMoreExtreme":8599,"size":5,"leadingEdge":["NR4A3","PARK7"]} {"pathway":"GO_GLYCEROL_TRANSPORT","pval":0.43858,"padj":0.90126,"ES":0.90153,"NES":1.32822,"nMoreExtreme":22420,"size":3,"leadingEdge":["AQP9","AQP3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MICROGLIAL_CELL_ACTIVATION","pval":0.33443,"padj":0.87575,"ES":0.93214,"NES":1.32741,"nMoreExtreme":17405,"size":4,"leadingEdge":["PTPRC","CX3CL1","GRN"]} {"pathway":"GO_NCRNA_3_END_PROCESSING","pval":0.04703,"padj":0.53858,"ES":0.92584,"NES":1.3273,"nMoreExtreme":3121,"size":34,"leadingEdge":["ERI1","ELAC2"]} {"pathway":"GO_PEPTIDYL_ASPARTIC_ACID_MODIFICATION","pval":0.03194,"padj":0.45611,"ES":0.99253,"NES":1.32718,"nMoreExtreme":1713,"size":6,"leadingEdge":["ATP13A2","ASPHD2"]} {"pathway":"GO_APOPTOTIC_PROCESS_INVOLVED_IN_HEART_MORPHOGENESIS","pval":0.33578,"padj":0.87575,"ES":0.93186,"NES":1.32701,"nMoreExtreme":17475,"size":4,"leadingEdge":["FOXC1","TGFB2"]} {"pathway":"GO_PARAXIAL_MESODERM_FORMATION","pval":0.33578,"padj":0.87575,"ES":0.93186,"NES":1.32701,"nMoreExtreme":17475,"size":4,"leadingEdge":["FOXC1","WNT5A"]} {"pathway":"GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION","pval":0.04449,"padj":0.5276,"ES":0.82384,"NES":1.32634,"nMoreExtreme":3375,"size":80,"leadingEdge":["CD74","SOCS1","IL12RB1","IL15","RIPK2","FLT3LG","CD80","CYLD","BTN2A2","HLA-G","BCL6","IL7","CD83","LILRB4","EGR3","DUSP10","CD86","RASGRP1","PTPRC","RUNX1","TGFB1","IL2RA","CCL19","GAS6","GATA3"]} {"pathway":"GO_OXYGEN_HOMEOSTASIS","pval":0.17156,"padj":0.77295,"ES":0.96393,"NES":1.32597,"nMoreExtreme":9077,"size":5,"leadingEdge":["SOD2","HIF1A"]} {"pathway":"GO_BETA_CATENIN_DESTRUCTION_COMPLEX_ASSEMBLY","pval":0.17266,"padj":0.77332,"ES":0.96377,"NES":1.32574,"nMoreExtreme":9135,"size":5,"leadingEdge":["AMER1","GSK3B"]} {"pathway":"GO_POST_TRANSLATIONAL_PROTEIN_MODIFICATION","pval":0.00527,"padj":0.18752,"ES":0.74417,"NES":1.32563,"nMoreExtreme":485,"size":308,"leadingEdge":["APOL1","UBD","PSME2","C4A","PSMB9","FBXO6","GOLM1","PSME1","PSMB10","NUB1","PSMB8","C3","SCG3","FEM1C","CISH","NUCB1","ASB2","CSF1","WSB1","IL6","PSMA4","PSMA2","VGF","CUL1","SOCS3","PSMA5"]} {"pathway":"GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS_BY_HOST","pval":0.05006,"padj":0.55243,"ES":0.92446,"NES":1.32533,"nMoreExtreme":3322,"size":34,"leadingEdge":["AIM2","IL12RB1","IL15","STAT1","IL27","APOBEC3G","ZC3H12A","DTX3L","PARP9","TNFAIP3","APOBEC3F","DDX58","LILRB1","CGAS"]} {"pathway":"GO_TRYPTOPHAN_CATABOLIC_PROCESS_TO_KYNURENINE","pval":0.17493,"padj":0.77529,"ES":0.96332,"NES":1.32512,"nMoreExtreme":9255,"size":5,"leadingEdge":["IDO1","IDO2","KYNU"]} {"pathway":"GO_POSITIVE_REGULATION_OF_T_CELL_TOLERANCE_INDUCTION","pval":0.17521,"padj":0.77529,"ES":0.96331,"NES":1.32511,"nMoreExtreme":9270,"size":5,"leadingEdge":["IDO1","HLA-G","LILRB2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_2_SIGNALING_PATHWAY","pval":0.17521,"padj":0.77529,"ES":0.96326,"NES":1.32504,"nMoreExtreme":9270,"size":5,"leadingEdge":["ACOD1","LYN","TNFAIP3"]} {"pathway":"GO_REGULATION_OF_VASCULAR_WOUND_HEALING","pval":0.17585,"padj":0.77529,"ES":0.96315,"NES":1.32489,"nMoreExtreme":9304,"size":5,"leadingEdge":["TNFAIP3","XBP1"]} {"pathway":"GO_PROTEIN_DEUBIQUITINATION_INVOLVED_IN_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS","pval":0.17585,"padj":0.77529,"ES":0.96315,"NES":1.32489,"nMoreExtreme":9304,"size":5,"leadingEdge":["TNFAIP3","ZRANB1"]} {"pathway":"GO_METANEPHRIC_NEPHRON_TUBULE_EPITHELIAL_CELL_DIFFERENTIATION","pval":0.04008,"padj":0.51243,"ES":0.99073,"NES":1.32478,"nMoreExtreme":2150,"size":6,"leadingEdge":["STAT1","WWTR1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_POLYMERIZATION","pval":0.0667,"padj":0.60375,"ES":0.8764,"NES":1.32428,"nMoreExtreme":4669,"size":48,"leadingEdge":["SPTBN4","SCIN","TMSB10","SPTA1","SLIT2"]} {"pathway":"GO_NOREPINEPHRINE_BIOSYNTHETIC_PROCESS","pval":0.34871,"padj":0.88316,"ES":0.92967,"NES":1.32389,"nMoreExtreme":18148,"size":4,"leadingEdge":["GATA3","MOXD1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INTERLEUKIN_13_SECRETION","pval":0.34871,"padj":0.88316,"ES":0.92967,"NES":1.32389,"nMoreExtreme":18148,"size":4,"leadingEdge":["GATA3","PRKCZ"]} {"pathway":"GO_PROTEIN_REPAIR","pval":0.04343,"padj":0.52235,"ES":0.99,"NES":1.3238,"nMoreExtreme":2330,"size":6,"leadingEdge":["MSRB1","PARK7"]} {"pathway":"GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE","pval":0.05754,"padj":0.57389,"ES":0.9188,"NES":1.32336,"nMoreExtreme":3834,"size":35,"leadingEdge":["TNF","ACTN2","GPM6B","STX3","FCER1G","HFE"]} {"pathway":"GO_REGULATION_OF_AUTOPHAGOSOME_ASSEMBLY","pval":0.05349,"padj":0.56014,"ES":0.92281,"NES":1.32297,"nMoreExtreme":3550,"size":34,"leadingEdge":["LRRK2","RALB","C9orf72"]} {"pathway":"GO_HYALURONAN_METABOLIC_PROCESS","pval":0.04645,"padj":0.53858,"ES":0.98933,"NES":1.3229,"nMoreExtreme":2492,"size":6,"leadingEdge":["IL15","HGF","PIM1","ITIH4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION","pval":0.18405,"padj":0.77988,"ES":0.96163,"NES":1.3228,"nMoreExtreme":9738,"size":5,"leadingEdge":["RNF207","KCNQ1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INTERFERON_ALPHA_PRODUCTION","pval":0.18405,"padj":0.77988,"ES":0.96163,"NES":1.3228,"nMoreExtreme":9738,"size":5,"leadingEdge":["NMI","LILRA4","PTPRS"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_HYDROGEN_PEROXIDE_MEDIATED_PROGRAMMED_CELL_DEATH","pval":0.18434,"padj":0.77988,"ES":0.96162,"NES":1.32278,"nMoreExtreme":9753,"size":5,"leadingEdge":["HGF","MET"]} {"pathway":"GO_EPITHELIAL_CELL_PROLIFERATION_INVOLVED_IN_SALIVARY_GLAND_MORPHOGENESIS","pval":0.35488,"padj":0.88844,"ES":0.92855,"NES":1.32229,"nMoreExtreme":18469,"size":4,"leadingEdge":["FGF10","TNF","NKX3-1","FGFR2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_OXIDATIVE_STRESS","pval":0.35601,"padj":0.88877,"ES":0.92832,"NES":1.32197,"nMoreExtreme":18528,"size":4,"leadingEdge":["NFE2L2","CHD6"]} {"pathway":"GO_POSITIVE_REGULATION_OF_COFACTOR_METABOLIC_PROCESS","pval":0.35601,"padj":0.88877,"ES":0.92832,"NES":1.32197,"nMoreExtreme":18528,"size":4,"leadingEdge":["NFE2L2","NNT"]} {"pathway":"GO_ARP2_3_COMPLEX_MEDIATED_ACTIN_NUCLEATION","pval":0.04531,"padj":0.53395,"ES":0.9313,"NES":1.32174,"nMoreExtreme":2979,"size":32,"leadingEdge":["ACTR3C","AP1AR","WAS"]} {"pathway":"GO_PROTEIN_K63_LINKED_DEUBIQUITINATION","pval":0.04104,"padj":0.51837,"ES":0.93626,"NES":1.32163,"nMoreExtreme":2686,"size":31,"leadingEdge":["STAMBPL1","CYLD","OTUD1","TNFAIP3","OTUD4","ZRANB1"]} {"pathway":"GO_PROTEIN_K48_LINKED_DEUBIQUITINATION","pval":0.04117,"padj":0.51837,"ES":0.9362,"NES":1.32155,"nMoreExtreme":2694,"size":31,"leadingEdge":["CYLD","TNFAIP3","VCPIP1","OTUD4","ATXN3"]} {"pathway":"GO_REGULATION_OF_XENOPHAGY","pval":0.05232,"padj":0.55686,"ES":0.98809,"NES":1.32125,"nMoreExtreme":2807,"size":6,"leadingEdge":["OPTN","RIPK2","MAPK3"]} {"pathway":"GO_INTERFERON_ALPHA_BIOSYNTHETIC_PROCESS","pval":0.19027,"padj":0.78825,"ES":0.96045,"NES":1.32118,"nMoreExtreme":10067,"size":5,"leadingEdge":["NMI","TLR8","TLR7","TLR3"]} {"pathway":"GO_HISTONE_CITRULLINATION","pval":0.01839,"padj":0.35375,"ES":0.99096,"NES":1.32081,"nMoreExtreme":919,"size":1,"leadingEdge":["PADI2"]} {"pathway":"GO_ACTIN_FILAMENT_POLYMERIZATION","pval":0.02376,"padj":0.39128,"ES":0.7708,"NES":1.32033,"nMoreExtreme":2004,"size":157,"leadingEdge":["PSTPIP2","MSRB1","JAK2","SPTBN4","ICAM1","SCIN","TMSB10","FAM107A","ACTR3C","CDC42EP2","AP1AR","SPTA1","SLIT2"]} {"pathway":"GO_RESPIRATORY_CHAIN_COMPLEX_IV_ASSEMBLY","pval":0.01595,"padj":0.3252,"ES":0.97351,"NES":1.32033,"nMoreExtreme":1009,"size":24,"leadingEdge":["SCO2","COX10"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE","pval":0.06325,"padj":0.59455,"ES":0.91649,"NES":1.32003,"nMoreExtreme":4215,"size":35,"leadingEdge":["XRN1","NBN","SRC","STN1","ERCC1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ANIMAL_ORGAN_MORPHOGENESIS","pval":0.05454,"padj":0.56183,"ES":0.834,"NES":1.31967,"nMoreExtreme":4036,"size":69,"leadingEdge":["AGT","PIM1","EDN1","CSF1","TNFAIP3","FGF10","SOX8","HPN","TGFB1","ROBO1","CFLAR","GATA3","PTN","SIX1"]} {"pathway":"GO_MHC_PROTEIN_COMPLEX_ASSEMBLY","pval":0.05925,"padj":0.58367,"ES":0.98657,"NES":1.31922,"nMoreExtreme":3179,"size":6,"leadingEdge":["HLA-DMA","HLA-DMB","HLA-DRA","HLA-DRB1","TAPBP"]} {"pathway":"GO_VESICLE_FUSION_WITH_ENDOPLASMIC_RETICULUM_GOLGI_INTERMEDIATE_COMPARTMENT_ERGIC_MEMBRANE","pval":0.05981,"padj":0.58367,"ES":0.98646,"NES":1.31907,"nMoreExtreme":3209,"size":6,"leadingEdge":["TAP2","TAP1","TAPBP"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_IMPORT","pval":0.36769,"padj":0.89036,"ES":0.92624,"NES":1.31901,"nMoreExtreme":19136,"size":4,"leadingEdge":["SPINK1","SLC30A1"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_HYPEROXIA","pval":0.06124,"padj":0.58982,"ES":0.98612,"NES":1.31862,"nMoreExtreme":3286,"size":6,"leadingEdge":["FAS","DNMT3B"]} {"pathway":"GO_PHOSPHATIDYLCHOLINE_BIOSYNTHETIC_PROCESS","pval":0.05652,"padj":0.57014,"ES":0.9241,"NES":1.3185,"nMoreExtreme":3735,"size":33,"leadingEdge":["PCYT1A","CDS1","MFSD2A","SLC44A2","RAB38","SLC44A1"]} {"pathway":"GO_MULTIVESICULAR_BODY_SORTING_PATHWAY","pval":0.04555,"padj":0.53588,"ES":0.93384,"NES":1.31821,"nMoreExtreme":2981,"size":31,"leadingEdge":["UVRAG","SORT1","RILP"]} {"pathway":"GO_REGULATION_OF_SALIVA_SECRETION","pval":0.37136,"padj":0.89036,"ES":0.92557,"NES":1.31805,"nMoreExtreme":19327,"size":4,"leadingEdge":["TIFAB","FGF10","NEUROG1"]} {"pathway":"GO_RETROGRADE_TRANS_SYNAPTIC_SIGNALING_BY_LIPID","pval":0.37167,"padj":0.89036,"ES":0.92551,"NES":1.31797,"nMoreExtreme":19343,"size":4,"leadingEdge":["PLCB1","DAGLA"]} {"pathway":"GO_CHEMOKINE_C_C_MOTIF_LIGAND_2_SECRETION","pval":0.06382,"padj":0.59614,"ES":0.98556,"NES":1.31787,"nMoreExtreme":3424,"size":6,"leadingEdge":["MCOLN2","FOXP1"]} {"pathway":"GO_NECROPTOTIC_SIGNALING_PATHWAY","pval":0.20342,"padj":0.79608,"ES":0.95792,"NES":1.3177,"nMoreExtreme":10763,"size":5,"leadingEdge":["FAS","TLR3","TNF"]} {"pathway":"GO_GLUTAMATE_BIOSYNTHETIC_PROCESS","pval":0.37355,"padj":0.89036,"ES":0.92523,"NES":1.31757,"nMoreExtreme":19441,"size":4,"leadingEdge":["GLS","SLC1A3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MYOSIN_LIGHT_CHAIN_PHOSPHATASE_ACTIVITY","pval":0.20393,"padj":0.79632,"ES":0.95781,"NES":1.31754,"nMoreExtreme":10790,"size":5,"leadingEdge":["TNF","ROCK1"]} {"pathway":"GO_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS","pval":0.07501,"padj":0.63068,"ES":0.88302,"NES":1.31747,"nMoreExtreme":5189,"size":44,"leadingEdge":["CD40","ICAM1","HLA-G","TNFAIP3","TNF","CCL2","ANGPTL4","GAS6","GATA3","NFE2L2"]} {"pathway":"GO_FLAVONOID_METABOLIC_PROCESS","pval":0.06605,"padj":0.60375,"ES":0.98506,"NES":1.31719,"nMoreExtreme":3544,"size":6,"leadingEdge":["CYP1A1","POR"]} {"pathway":"GO_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_DIFFERENTIATION","pval":0.07636,"padj":0.63457,"ES":0.88926,"NES":1.31694,"nMoreExtreme":5235,"size":42,"leadingEdge":["SOCS1","IL12RB1","TBX21","RIPK2","IL27","CD80","ZC3H12A","JAK3","BCL6","CD83","IRF4","CD86","RUNX1","CCL19","SH3RF1","GATA3","HLX"]} {"pathway":"GO_PHOTOTRANSDUCTION","pval":0.03404,"padj":0.4724,"ES":0.94763,"NES":1.31691,"nMoreExtreme":2198,"size":28,"leadingEdge":["CDS1","GUCA1A","PLEKHB1"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_BIOTIC_STIMULUS","pval":0.01762,"padj":0.34872,"ES":0.75634,"NES":1.31676,"nMoreExtreme":1536,"size":199,"leadingEdge":["CD40","CD274","CXCL11","PDCD1LG2","PDE4B","CXCL10","NOD2","ACOD1","CXCL9","RIPK2","ICAM1","BCL2L11","CD80","ZC3H12A","CARD17","STAP1","CARD16","LILRA2","IL1RN","SBNO2","CMPK2","LITAF","CCL5","LYN","TICAM2","PLSCR4","TNFAIP3","IL6","TNF","CD86","CCR5","PTAFR","NR1H3","LILRB1","CCL2","KMO","SRC","TGFB1","CXCL8","TXNIP","NFKBIA","CCL3","CX3CL1","CASP1"]} {"pathway":"GO_SMALL_MOLECULE_CATABOLIC_PROCESS","pval":0.00664,"padj":0.21408,"ES":0.73817,"NES":1.31634,"nMoreExtreme":614,"size":314,"leadingEdge":["IDO1","GK","IDO2","DPYS","IL4I1","TYMP","CYP1A1","HSD3B7","SCARF1","APOBEC3D","ENPP4","APOBEC3A","APOBEC3G","CBR3","ACOT4","GLUL","KYNU","APOBEC3F","SDSL","DECR1","PFKP","CYP27B1","KMO","HPD","ADA2","MMAA","NAGK","GPD2","FUT4","GLS","ACBD5","GALM","CPT1A","ENTPD2"]} {"pathway":"GO_CELL_MIGRATION_INVOLVED_IN_KIDNEY_DEVELOPMENT","pval":0.37918,"padj":0.89036,"ES":0.92428,"NES":1.31621,"nMoreExtreme":19734,"size":4,"leadingEdge":["PDGFB","PDGFRB"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS","pval":0.37918,"padj":0.89036,"ES":0.92428,"NES":1.31621,"nMoreExtreme":19734,"size":4,"leadingEdge":["PDGFB","SLC27A1"]} {"pathway":"GO_REGULATION_OF_LUNG_BLOOD_PRESSURE","pval":0.37978,"padj":0.89036,"ES":0.92417,"NES":1.31605,"nMoreExtreme":19765,"size":4,"leadingEdge":["GCH1","NAMPT","SMAD3"]} {"pathway":"GO_SENSORY_PERCEPTION_OF_BITTER_TASTE","pval":0.07004,"padj":0.61798,"ES":0.9841,"NES":1.31592,"nMoreExtreme":3758,"size":6,"leadingEdge":["RTP4","ITPR3"]} {"pathway":"GO_HEMOGLOBIN_BIOSYNTHETIC_PROCESS","pval":0.07041,"padj":0.61978,"ES":0.98404,"NES":1.31584,"nMoreExtreme":3778,"size":6,"leadingEdge":["KLF4","EIF2AK1"]} {"pathway":"GO_INTERFERON_BETA_PRODUCTION","pval":0.07399,"padj":0.62748,"ES":0.8733,"NES":1.31583,"nMoreExtreme":5163,"size":47,"leadingEdge":["IRF1","NMI","RIPK2","TLR8","IRF7","IFIH1","RELB","TLR7","TLR3","DDX58","LILRB1","IRF5","FLOT1","TLR4","TICAM1","POLR3D"]} {"pathway":"GO_MODULATION_BY_SYMBIONT_OF_HOST_APOPTOTIC_PROCESS","pval":0.2121,"padj":0.79938,"ES":0.95629,"NES":1.31546,"nMoreExtreme":11222,"size":5,"leadingEdge":["BCL2L11","SERPINB9","BAD"]} {"pathway":"GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY","pval":0.05695,"padj":0.57189,"ES":0.82957,"NES":1.31538,"nMoreExtreme":4228,"size":70,"leadingEdge":["SAMD4A","ZFP36","BTG2","EDC4"]} {"pathway":"GO_REGULATION_OF_LONG_TERM_NEURONAL_SYNAPTIC_PLASTICITY","pval":0.00729,"padj":0.22406,"ES":0.98943,"NES":1.31533,"nMoreExtreme":453,"size":21,"leadingEdge":["KCNJ10","AGT","CAMK2B"]} {"pathway":"GO_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY","pval":0.06299,"padj":0.59455,"ES":0.84338,"NES":1.31522,"nMoreExtreme":4577,"size":61,"leadingEdge":["P2RX7","IL12RB1","TBX21","HLA-F","CEACAM1","HLA-B","HLA-E","HLA-A","HLA-C","B2M","RSAD2","HLA-G","IL12A","IL6","PTPRC","LILRB1"]} {"pathway":"GO_REGULATION_OF_T_HELPER_17_CELL_LINEAGE_COMMITMENT","pval":0.21378,"padj":0.7999,"ES":0.95602,"NES":1.31508,"nMoreExtreme":11311,"size":5,"leadingEdge":["IL12RB1","TBX21","IL12B"]} {"pathway":"GO_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_I_PROMOTER","pval":0.04011,"padj":0.51243,"ES":0.94127,"NES":1.31505,"nMoreExtreme":2602,"size":29,"leadingEdge":["TAF1A","MNAT1"]} {"pathway":"GO_VIRAL_BUDDING","pval":0.01997,"padj":0.36056,"ES":0.96952,"NES":1.31492,"nMoreExtreme":1264,"size":24,"leadingEdge":["CHMP4C","VTA1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INTERLEUKIN_6_PRODUCTION","pval":0.05627,"padj":0.56995,"ES":0.82626,"NES":1.31475,"nMoreExtreme":4198,"size":72,"leadingEdge":["P2RX7","NOD2","RIPK2","TLR8","IFIH1","LILRA2","IL1RN","TLR7","MYD88","IL6","TLR3","TNF","PTAFR","DDX58","STAT3","AKIRIN2","IL33","FCER1G","LILRA5","TLR4","EREG","TICAM1","SIGLEC16","TLR1","LILRB2"]} {"pathway":"GO_RESPONSE_TO_METHYLMERCURY","pval":0.21594,"padj":0.80167,"ES":0.95567,"NES":1.3146,"nMoreExtreme":11425,"size":5,"leadingEdge":["ANK2","ARSB"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION","pval":0.05062,"padj":0.55466,"ES":0.93124,"NES":1.31455,"nMoreExtreme":3313,"size":31,"leadingEdge":["SOCS1","CD274","TBX21","ZC3H12A","JAK3","BCL6","TNFRSF14","LILRB1","RUNX1","HLX","ADORA2A"]} {"pathway":"GO_INTRACELLULAR_LIPID_TRANSPORT","pval":0.07281,"padj":0.62369,"ES":0.91267,"NES":1.31452,"nMoreExtreme":4852,"size":35,"leadingEdge":["CES1","CPT1A","NPC1","SYT7"]} {"pathway":"GO_REGULATION_OF_PROTEIN_DEACETYLATION","pval":0.07307,"padj":0.62434,"ES":0.9126,"NES":1.31443,"nMoreExtreme":4869,"size":35,"leadingEdge":["LRRK2","CAMK2D","BCL6","TGFB1","AKAP8L"]} {"pathway":"GO_INTERLEUKIN_1_BETA_SECRETION","pval":0.07883,"padj":0.63581,"ES":0.88749,"NES":1.31432,"nMoreExtreme":5405,"size":42,"leadingEdge":["GBP5","AIM2","P2RX7","NOD2","RIPK2","TLR8","GSDMD","PML","ZC3H12A","CARD17","CARD16","LILRA2","TNFAIP3","CCL19","CCL3","CASP1"]} {"pathway":"GO_MEIOTIC_TELOMERE_CLUSTERING","pval":0.21767,"padj":0.80167,"ES":0.95534,"NES":1.31414,"nMoreExtreme":11517,"size":5,"leadingEdge":["MEI1","MLH1"]} {"pathway":"GO_RESPIRATORY_BURST_INVOLVED_IN_INFLAMMATORY_RESPONSE","pval":0.21796,"padj":0.80167,"ES":0.95528,"NES":1.31407,"nMoreExtreme":11532,"size":5,"leadingEdge":["SLAMF8","DUSP10","GRN"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_RESPIRATORY_BURST","pval":0.21796,"padj":0.80167,"ES":0.95528,"NES":1.31407,"nMoreExtreme":11532,"size":5,"leadingEdge":["SLAMF8","DUSP10","GRN"]} {"pathway":"GO_COBALT_ION_TRANSPORT","pval":0.22023,"padj":0.80441,"ES":0.95489,"NES":1.31353,"nMoreExtreme":11652,"size":5,"leadingEdge":["TCN2","SLC11A2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELL_PROLIFERATION_IN_BONE_MARROW","pval":0.07762,"padj":0.63581,"ES":0.9823,"NES":1.31351,"nMoreExtreme":4165,"size":6,"leadingEdge":["FLT3LG","FGFR2"]} {"pathway":"GO_ORGANELLE_MEMBRANE_FUSION","pval":0.04852,"padj":0.5476,"ES":0.80734,"NES":1.31233,"nMoreExtreme":3731,"size":88,"leadingEdge":["TAP2","TAP1","STX11","SAMD9L","TAPBP","PRRT2","RAB20","DYSF","VCPIP1","TRIM9","UVRAG","SAMD9","STX3","RAB39A","STX17"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CHOLESTEROL_ESTERIFICATION","pval":0.08213,"padj":0.64602,"ES":0.98141,"NES":1.31232,"nMoreExtreme":4407,"size":6,"leadingEdge":["AGT","APOA1"]} {"pathway":"GO_DENDRITIC_CELL_DIFFERENTIATION","pval":0.08116,"padj":0.64456,"ES":0.90688,"NES":1.31205,"nMoreExtreme":5436,"size":36,"leadingEdge":["UBD","BATF2","TMEM176A","TMEM176B","BATF3","HLA-G","RELB","LYN","IRF4","LILRB1","TGFB1","CCL19","GAS6"]} {"pathway":"GO_BRUSH_BORDER_ASSEMBLY","pval":0.03168,"padj":0.45328,"ES":0.98422,"NES":1.31182,"nMoreExtreme":1584,"size":1,"leadingEdge":["MYO7B"]} {"pathway":"GO_PML_BODY_ORGANIZATION","pval":0.08435,"padj":0.65161,"ES":0.98101,"NES":1.31178,"nMoreExtreme":4526,"size":6,"leadingEdge":["PML","HIPK2"]} {"pathway":"GO_FATTY_ACYL_COA_BIOSYNTHETIC_PROCESS","pval":0.03516,"padj":0.47945,"ES":0.9496,"NES":1.31169,"nMoreExtreme":2260,"size":27,"leadingEdge":["ACSL1","ACSL5","ELOVL7","ELOVL5"]} {"pathway":"GO_REGULATION_OF_PROTEIN_IMPORT","pval":0.07351,"padj":0.62601,"ES":0.86077,"NES":1.3116,"nMoreExtreme":5192,"size":51,"leadingEdge":["ZC3H12A","TGFB1","PTGS2","SMAD3","CDH1"]} {"pathway":"GO_INTERLEUKIN_1_PRODUCTION","pval":0.05402,"padj":0.56056,"ES":0.81567,"NES":1.31145,"nMoreExtreme":4089,"size":79,"leadingEdge":["GBP5","AIM2","P2RX7","NOD2","CEACAM1","JAK2","SUCNR1","RIPK2","TLR8","GSDMD","PML","MEFV","S100A13","ZC3H12A","CARD17","CARD16","LILRA2","TNFAIP3","MR1","CCL19","GAS6","CCL3","CX3CL1","CASP1","IL1R2","SMAD3"]} {"pathway":"GO_RESPONSE_TO_IRON_III_ION","pval":0.08629,"padj":0.65271,"ES":0.98062,"NES":1.31126,"nMoreExtreme":4630,"size":6,"leadingEdge":["CYP1A1","B2M","CCNB1"]} {"pathway":"GO_REGULATION_OF_MORPHOGENESIS_OF_AN_EPITHELIUM","pval":0.02712,"padj":0.41718,"ES":0.76426,"NES":1.31125,"nMoreExtreme":2294,"size":161,"leadingEdge":["PSME2","PSMB9","CXCL10","HGF","PSME1","STAT1","PSMB10","AGT","PSMB8","RNF207","FGF10","TNF","SOX8","PSMA4","PSMA2","TGFB1","PSMA5","GATA3"]} {"pathway":"GO_KERATINOCYTE_APOPTOTIC_PROCESS","pval":0.39851,"padj":0.89503,"ES":0.92074,"NES":1.31117,"nMoreExtreme":20740,"size":4,"leadingEdge":["ZFP36","PIAS4"]} {"pathway":"GO_PUTRESCINE_BIOSYNTHETIC_PROCESS","pval":0.23145,"padj":0.81508,"ES":0.95298,"NES":1.3109,"nMoreExtreme":12246,"size":5,"leadingEdge":["AZIN2","ODC1"]} {"pathway":"GO_REGULATION_OF_POLYAMINE_TRANSMEMBRANE_TRANSPORT","pval":0.23145,"padj":0.81508,"ES":0.95298,"NES":1.3109,"nMoreExtreme":12246,"size":5,"leadingEdge":["AZIN2","OAZ1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_LIPOPROTEIN_LIPASE_ACTIVITY","pval":0.39972,"padj":0.89503,"ES":0.92053,"NES":1.31086,"nMoreExtreme":20803,"size":4,"leadingEdge":["ANGPTL4","SORT1","HDAC9"]} {"pathway":"GO_SPHINGOMYELIN_CATABOLIC_PROCESS","pval":0.23156,"padj":0.81508,"ES":0.95292,"NES":1.31082,"nMoreExtreme":12252,"size":5,"leadingEdge":["SMPD3","SMPD2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_CHEMOTAXIS","pval":0.40043,"padj":0.89503,"ES":0.9204,"NES":1.31069,"nMoreExtreme":20840,"size":4,"leadingEdge":["SLIT2","GSTP1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION","pval":0.40043,"padj":0.89503,"ES":0.9204,"NES":1.31069,"nMoreExtreme":20840,"size":4,"leadingEdge":["SLIT2","KANK1"]} {"pathway":"GO_TRANSPOSITION_RNA_MEDIATED","pval":0.23238,"padj":0.81508,"ES":0.95276,"NES":1.31059,"nMoreExtreme":12295,"size":5,"leadingEdge":["MOV10","TUT7"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION","pval":0.01625,"padj":0.32909,"ES":0.74808,"NES":1.31055,"nMoreExtreme":1437,"size":222,"leadingEdge":["IDO1","GBP1","CD274","PDCD1LG2","LAG3","TBX21","HLA-F","CEACAM1","HGF","NLRC5","ACOD1","BANK1","NMI","TLR8","UBE2L6","KLF4","PML","MEFV","ZC3H12A","JAK3","CYLD","CARD17","CARD16","BTN2A2","IFIH1","SLAMF1","PTGER4","RELB","BCL6","IL12A","CD83","TNFAIP3","LILRA4","IL6","TNF","GPR18","PTPRC","DDX58","LILRB1","DHX58","TGFB1","IKBKE","ISG15","GAS6","CX3CL1","TRIM25","GATA3","IL33"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PEPTIDASE_ACTIVITY","pval":0.02764,"padj":0.41718,"ES":0.76406,"NES":1.31042,"nMoreExtreme":2337,"size":160,"leadingEdge":["PSME2","AIM2","TNFSF10","PSME1","JAK2","RIPK2","FAS","BCL2L11","PML","MEFV","CASP4","PMAIP1","LYN","TANK","CASP10","TNF","CASP5","F3","STAT3","ROBO1","AKIRIN2","PRELID1","CFLAR","CASP1","NKX3-1","BBC3","SMAD3","BAK1","NGF"]} {"pathway":"GO_CD8_POSITIVE_ALPHA_BETA_T_CELL_PROLIFERATION","pval":0.23402,"padj":0.81652,"ES":0.95248,"NES":1.31021,"nMoreExtreme":12382,"size":5,"leadingEdge":["IRF1","HLA-E","SH3RF1"]} {"pathway":"GO_MODIFICATION_OF_MORPHOLOGY_OR_PHYSIOLOGY_OF_OTHER_ORGANISM","pval":0.04249,"padj":0.52235,"ES":0.78967,"NES":1.31002,"nMoreExtreme":3379,"size":107,"leadingEdge":["APOL1","P2RX7","CCL13","IFI27","BCL2L11","GSDMD","CCL8","ZC3H12A","KPNA5","CCL5","HPN","SERPINB9","CCL4","TGFB1","CCL3","SMAD3","STOM"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PROTEOLYSIS","pval":0.01492,"padj":0.31301,"ES":0.74553,"NES":1.30989,"nMoreExtreme":1330,"size":235,"leadingEdge":["C4A","LRRK2","C4B","SERPING1","LAMP3","HGF","AGT","PZP","KLF4","PML","C3","CARD17","CARD16","CHAC1","BIRC3","CTSZ","SERPINB9","SRC","A2M","TRIM21","UBE2Z","IFI6","SH3RF1","PTGS2","GAS6","CFLAR","BIRC7","SERPINB1","SPINK1","HERPUD1","IL1R2","HMSD","NGF","TNFAIP8"]} {"pathway":"GO_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE","pval":0.0276,"padj":0.41718,"ES":0.76339,"NES":1.30976,"nMoreExtreme":2335,"size":161,"leadingEdge":["IL31RA","CD40","CD74","TBX21","NOD2","HLA-F","HLA-DQB1","HLA-E","TNFSF13B","B2M","JAK3","RSAD2","HLA-G","POLB","GCNT3","BCL6","NR4A3","TNFRSF14","PARP3","DENND1B","IL6","TLR3","SEMA7A","TNF","MR1","CD226","PTPRC","DDX58","LILRB1","NBN","TGFB1","CGAS","CCR6","LIG4","GAS6","GATA3","IL33"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION","pval":0.09119,"padj":0.66096,"ES":0.97944,"NES":1.30968,"nMoreExtreme":4893,"size":6,"leadingEdge":["SRI","ZC3H12A","PIK3CG"]} {"pathway":"GO_REGULATION_OF_VIRAL_LIFE_CYCLE","pval":0.03512,"padj":0.47945,"ES":0.77672,"NES":1.30961,"nMoreExtreme":2873,"size":129,"leadingEdge":["CD74","LAMP3","ISG20","IFI27","IFITM2","APOBEC3D","IFITM1","PML","CCL8","APOBEC3A","APOBEC3G","ZC3H12A","PARP10","RSAD2","TRIM31","IFITM3","CHMP4C","CCL5","IFIT5","OAS3","PLSCR1","APOBEC3F","TNF","MX1","CXCL8","TRIM21","ADAR","ISG15","TRIM25"]} {"pathway":"GO_NEURON_MATURATION","pval":0.08604,"padj":0.65271,"ES":0.89361,"NES":1.3096,"nMoreExtreme":5843,"size":39,"leadingEdge":["LRRK2","GLDN","SPTBN4","SCARF1","C3","NRCAM","RND1","B4GALT5","FARP2","NR4A2","CDKN1C","CX3CL1"]} {"pathway":"GO_NORADRENERGIC_NEURON_DIFFERENTIATION","pval":0.23723,"padj":0.82177,"ES":0.95197,"NES":1.30951,"nMoreExtreme":12552,"size":5,"leadingEdge":["ASCL1","SOX4"]} {"pathway":"GO_PROTEIN_IMPORT","pval":0.02649,"padj":0.40858,"ES":0.76175,"NES":1.30915,"nMoreExtreme":2249,"size":165,"leadingEdge":["AGT","PML","ZC3H12A","KPNA5","STAT3","TGFB1","TXNIP","PTGS2","SMAD3","PRICKLE1"]} {"pathway":"GO_MEMBRANE_DISRUPTION_IN_OTHER_ORGANISM","pval":0.03579,"padj":0.48389,"ES":0.98214,"NES":1.30905,"nMoreExtreme":1790,"size":1,"leadingEdge":["GSDMD"]} {"pathway":"GO_ACTIVATED_T_CELL_PROLIFERATION","pval":0.08259,"padj":0.64653,"ES":0.90887,"NES":1.30905,"nMoreExtreme":5504,"size":35,"leadingEdge":["CD274","IL12RB1","PDCD1LG2","BTN3A1","BTN2A2","IL2RA"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PROTEIN_K63_LINKED_UBIQUITINATION","pval":0.0938,"padj":0.66439,"ES":0.97893,"NES":1.309,"nMoreExtreme":5033,"size":6,"leadingEdge":["PARP10","UBR5"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INTERLEUKIN_10_SECRETION","pval":0.23967,"padj":0.82313,"ES":0.95156,"NES":1.30895,"nMoreExtreme":12681,"size":5,"leadingEdge":["CD274","LILRA5"]} {"pathway":"GO_REGULATION_OF_STEROL_TRANSPORT","pval":0.05423,"padj":0.56056,"ES":0.93189,"NES":1.30885,"nMoreExtreme":3534,"size":30,"leadingEdge":["TTC39B","LIPG","NR1H3","NFKBIA","ABCB4"]} {"pathway":"GO_CELLULAR_ALCOHOL_METABOLIC_PROCESS","pval":0.24039,"padj":0.82313,"ES":0.95135,"NES":1.30866,"nMoreExtreme":12719,"size":5,"leadingEdge":["CYP27B1","FDFT1"]} {"pathway":"GO_SKELETAL_MUSCLE_CELL_DIFFERENTIATION","pval":0.07703,"padj":0.63581,"ES":0.86139,"NES":1.30858,"nMoreExtreme":5417,"size":50,"leadingEdge":["EGR2","ATF3","MAFF","ASB2","SOX8","NUPR1","FOXN2","PAX5","TBX1","BTG2","SIX1"]} {"pathway":"GO_NEUROMUSCULAR_PROCESS","pval":0.0626,"padj":0.59455,"ES":0.82812,"NES":1.30841,"nMoreExtreme":4625,"size":68,"leadingEdge":["GCH1","GRIN3A","PRRT2","COMP","TIFAB","NR4A3","JPH4","NBN","GM2A","ADORA2A","NEUROG1"]} {"pathway":"GO_SUCCINYL_COA_METABOLIC_PROCESS","pval":0.0965,"padj":0.66591,"ES":0.97831,"NES":1.30818,"nMoreExtreme":5178,"size":6,"leadingEdge":["ACOT4","OGDH"]} {"pathway":"GO_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION","pval":0.01677,"padj":0.33463,"ES":0.7461,"NES":1.30807,"nMoreExtreme":1486,"size":225,"leadingEdge":["IRF1","CD74","HLA-DOA","SOCS1","IL12RB1","IL15","TBX21","CEACAM1","CTLA4","TMEM176A","TMEM176B","RIPK2","IL27","LILRB3","FLT3LG","CD80","ZC3H12A","JAK3","CYLD","IRF7","BTN2A2","HLA-G","SLAMF8","BCL6","LYN","CSF1","IL7","CD83","IRF4","TLR3","LILRB4","EGR3","NOTCH2","TNF","DUSP10","CD86","RASGRP1","PTPRC","LILRB1","PTPN2","RUNX1","TGFB1","OCSTAMP","IL2RA","CCL19","C1QC","SH3RF1","GAS6","CCL3","PRELID1","GATA3","PPARGC1B"]} {"pathway":"GO_REGULATION_OF_MAST_CELL_ACTIVATION","pval":0.08592,"padj":0.65271,"ES":0.90749,"NES":1.30707,"nMoreExtreme":5726,"size":35,"leadingEdge":["CD300LF","LYN","NR4A3","PLSCR1","CD226","FCER1G","CD84","FGR"]} {"pathway":"GO_ENERGY_COUPLED_PROTON_TRANSPORT_DOWN_ELECTROCHEMICAL_GRADIENT","pval":0.01297,"padj":0.29199,"ES":0.98308,"NES":1.30689,"nMoreExtreme":806,"size":21,"leadingEdge":["VPS9D1","ATP5F1D"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PANCREATIC_JUICE_SECRETION","pval":0.2475,"padj":0.82387,"ES":0.95006,"NES":1.30688,"nMoreExtreme":13095,"size":5,"leadingEdge":["NR1H3","WNK1"]} {"pathway":"GO_INTERFERON_BETA_SECRETION","pval":0.2478,"padj":0.82387,"ES":0.95,"NES":1.3068,"nMoreExtreme":13111,"size":5,"leadingEdge":["IFIH1","DDX58","LILRB1","MAVS"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CYTOKINE_SECRETION_INVOLVED_IN_IMMUNE_RESPONSE","pval":0.24804,"padj":0.82387,"ES":0.94995,"NES":1.30673,"nMoreExtreme":13124,"size":5,"leadingEdge":["TNF","LILRB1","APOA1"]} {"pathway":"GO_REGULATION_OF_T_CELL_ACTIVATION_VIA_T_CELL_RECEPTOR_CONTACT_WITH_ANTIGEN_BOUND_TO_MHC_MOLECULE_ON_ANTIGEN_PRESENTING_CELL","pval":0.24804,"padj":0.82387,"ES":0.94995,"NES":1.30673,"nMoreExtreme":13124,"size":5,"leadingEdge":["HLA-DMB","LILRB1"]} {"pathway":"GO_TRANSFORMING_GROWTH_FACTOR_BETA_SECRETION","pval":0.2485,"padj":0.82387,"ES":0.94989,"NES":1.30665,"nMoreExtreme":13148,"size":5,"leadingEdge":["LILRB1","FERMT1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PROTEIN_TARGETING_TO_MEMBRANE","pval":0.2494,"padj":0.82387,"ES":0.94972,"NES":1.30642,"nMoreExtreme":13196,"size":5,"leadingEdge":["KCNE1","ITGB1BP1"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_UV_C","pval":0.10293,"padj":0.6741,"ES":0.97697,"NES":1.30638,"nMoreExtreme":5523,"size":6,"leadingEdge":["CARD16","MDM2"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_EXTERNAL_STIMULUS","pval":0.01024,"padj":0.25928,"ES":0.73527,"NES":1.30628,"nMoreExtreme":937,"size":292,"leadingEdge":["IRF1","CD40","P2RX7","LRRK2","IL15","ATF3","AGT","PIM1","TLR8","FAS","KCNJ2","VCAM1","ICAM1","GSDMD","ZC3H12A","P2RX4","RALB","FAM107A","PMAIP1","PTGER4","LYN","GLUL","TLR7","CADPS2","MYD88","TLR3","NCOA1","CYP27B1","PTPRC","NR4A2","SIK1B","CASP5","P2RY12","NUAK2","GCLC","TGFB1","CDKN1A","UCP2","NAMPT","RRAGC","P2RY2","PTGS2","GAS6","ASNS","RRAGD","CASP1","NFE2L2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_KINASE_C_SIGNALING","pval":0.00567,"padj":0.19529,"ES":0.99843,"NES":1.30602,"nMoreExtreme":307,"size":7,"leadingEdge":["CD40","FLT4"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY","pval":0.05356,"padj":0.56014,"ES":0.93465,"NES":1.30581,"nMoreExtreme":3475,"size":29,"leadingEdge":["TBX21","HLA-F","CEACAM1","HLA-E","HLA-G","BCL6","PARP3","SERPINB9","PTPRC","LILRB1"]} {"pathway":"GO_COENZYME_TRANSPORT","pval":0.00668,"padj":0.21408,"ES":0.99809,"NES":1.30558,"nMoreExtreme":362,"size":7,"leadingEdge":["P2RX7","SLC23A2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_DEPOLARIZATION","pval":0.00668,"padj":0.21408,"ES":0.99809,"NES":1.30558,"nMoreExtreme":362,"size":7,"leadingEdge":["P2RX7","DCN"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE","pval":0.09264,"padj":0.66428,"ES":0.90221,"NES":1.30529,"nMoreExtreme":6205,"size":36,"leadingEdge":["TBX21","HLA-F","CEACAM1","ZC3H12A","JAK3","HLA-G","BCL6","TNFRSF14","PARP3","PTPRC","LILRB1","IL33"]} {"pathway":"GO_B_CELL_RECEPTOR_SIGNALING_PATHWAY","pval":0.0842,"padj":0.65144,"ES":0.86881,"NES":1.30506,"nMoreExtreme":5860,"size":46,"leadingEdge":["ITK","CD38","CTLA4","STAP1","LYN","PTPRC","MNDA","RUNX1","NFAM1","PAX5","KLHL6"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM_EXIT_SITE","pval":0.00881,"padj":0.24715,"ES":0.99753,"NES":1.30484,"nMoreExtreme":478,"size":7,"leadingEdge":["LRRK2","BCAP29"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MITOCHONDRION","pval":0.00881,"padj":0.24715,"ES":0.99753,"NES":1.30484,"nMoreExtreme":478,"size":7,"leadingEdge":["LRRK2","LMAN1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_CELL_PROLIFERATION","pval":0.25655,"padj":0.82758,"ES":0.94854,"NES":1.30479,"nMoreExtreme":13574,"size":5,"leadingEdge":["MIR503","FLT1","CCL2","MEF2C"]} {"pathway":"GO_REGULATION_OF_LIPOPROTEIN_METABOLIC_PROCESS","pval":0.25691,"padj":0.82758,"ES":0.94851,"NES":1.30475,"nMoreExtreme":13593,"size":5,"leadingEdge":["DGAT2","LIPG","PEMT"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MAPK_CASCADE","pval":0.03341,"padj":0.46677,"ES":0.76647,"NES":1.30441,"nMoreExtreme":2781,"size":145,"leadingEdge":["GBP1","P2RX7","ATF3","KLF4","CYLD","BTN2A2","MIR503","LYN","DUSP10","PTPRC","PTPN2","DUSP5","PTPN1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NLRP3_INFLAMMASOME_COMPLEX_ASSEMBLY","pval":0.11038,"padj":0.69745,"ES":0.97545,"NES":1.30435,"nMoreExtreme":5923,"size":6,"leadingEdge":["GBP5","TLR4","DHX33"]} {"pathway":"GO_KYNURENINE_METABOLIC_PROCESS","pval":0.25927,"padj":0.82758,"ES":0.94815,"NES":1.30425,"nMoreExtreme":13718,"size":5,"leadingEdge":["KMO","AADAT"]} {"pathway":"GO_LEUKOCYTE_MEDIATED_CYTOTOXICITY","pval":0.05744,"padj":0.57368,"ES":0.80913,"NES":1.30425,"nMoreExtreme":4363,"size":81,"leadingEdge":["P2RX7","IL12RB1","SLAMF7","LAG3","HLA-F","CEACAM1","HLA-B","HLA-E","HLA-A","HLA-C","ICAM1","B2M","SLAMF6","STAP1","HLA-G","IL12A","SERPINB9","CD226","RASGRP1","PTPRC","LILRB1","PRDX1","CTSC"]} {"pathway":"GO_REGULATION_OF_PEPTIDYL_SERINE_DEPHOSPHORYLATION","pval":0.42751,"padj":0.89886,"ES":0.91557,"NES":1.30381,"nMoreExtreme":22249,"size":4,"leadingEdge":["PPP1R16B","PPP1R15A"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_APOPTOTIC_PROCESS","pval":0.11306,"padj":0.69864,"ES":0.97489,"NES":1.3036,"nMoreExtreme":6067,"size":6,"leadingEdge":["EDN1","IGF1"]} {"pathway":"GO_RESPONSE_TO_OXYGEN_LEVELS","pval":0.00788,"padj":0.23434,"ES":0.72942,"NES":1.30351,"nMoreExtreme":733,"size":331,"leadingEdge":["PSME2","ASCL2","PSMB9","CD38","PSME1","PSMB10","FAS","PSMB8","VCAM1","CYP1A1","ICAM1","PML","CARD16","EDN1","VEGFC","PMAIP1","POLB","BACH1","LTA","PSMA4","SLC8A1","PSMA2","CXCL12","NR4A2","PSEN2","PAK1","ANGPTL4","SRC","TGFB1","KCNMA1","CDKN1A","PSMA5","UCP2","ATP6V1A","NAMPT","LPAR1","PTGS2","CFLAR","AGTRAP","NKX3-1","NFE2L2","SMAD3"]} {"pathway":"GO_MACROPHAGE_COLONY_STIMULATING_FACTOR_SIGNALING_PATHWAY","pval":0.26326,"padj":0.83229,"ES":0.94747,"NES":1.30333,"nMoreExtreme":13929,"size":5,"leadingEdge":["STAP1","CSF1","PTPN2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_INTERFERON_GAMMA","pval":0.26326,"padj":0.83229,"ES":0.94747,"NES":1.30333,"nMoreExtreme":13929,"size":5,"leadingEdge":["PARP14","NR1H3","PTPN2"]} {"pathway":"GO_MODULATION_BY_SYMBIONT_OF_HOST_CELLULAR_PROCESS","pval":0.05229,"padj":0.55686,"ES":0.93778,"NES":1.30322,"nMoreExtreme":3377,"size":28,"leadingEdge":["BCL2L11","CCL8","ZC3H12A","KPNA5","SERPINB9","BAD"]} {"pathway":"GO_PLASMA_MEMBRANE_RAFT_ASSEMBLY","pval":0.43173,"padj":0.90013,"ES":0.91473,"NES":1.30261,"nMoreExtreme":22469,"size":4,"leadingEdge":["FLOT1","PACSIN2"]} {"pathway":"GO_REGULATION_OF_TYPE_I_INTERFERON_MEDIATED_SIGNALING_PATHWAY","pval":0.05934,"padj":0.58367,"ES":0.93222,"NES":1.3024,"nMoreExtreme":3850,"size":29,"leadingEdge":["NLRC5","ZBP1","IRF7","PTPN2","IKBKE","PTPN1","USP18"]} {"pathway":"GO_COMMITMENT_OF_NEURONAL_CELL_TO_SPECIFIC_NEURON_TYPE_IN_FOREBRAIN","pval":0.26715,"padj":0.83635,"ES":0.94678,"NES":1.30236,"nMoreExtreme":14135,"size":5,"leadingEdge":["ASCL1","SATB2"]} {"pathway":"GO_REGULATION_OF_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE","pval":0.08582,"padj":0.65271,"ES":0.86431,"NES":1.3023,"nMoreExtreme":5989,"size":47,"leadingEdge":["LRRK2","HGF","AGT","FGF10","TNF","SOX8","TGFB1","HNF1B","SIX1"]} {"pathway":"GO_VACUOLE_ORGANIZATION","pval":0.03295,"padj":0.46522,"ES":0.76185,"NES":1.30208,"nMoreExtreme":2766,"size":153,"leadingEdge":["P2RX7","LRRK2","ATP13A2","RAB20","RALB","RUFY4","ATG3","RAB39A","STX17","C9orf72"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INTEGRIN_ACTIVATION","pval":0.27031,"padj":0.83739,"ES":0.94618,"NES":1.30155,"nMoreExtreme":14302,"size":5,"leadingEdge":["PLEK","P2RY12","SRC"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CD8_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION","pval":0.27031,"padj":0.83739,"ES":0.94618,"NES":1.30155,"nMoreExtreme":14302,"size":5,"leadingEdge":["HLA-E","RUNX1","RUNX3"]} {"pathway":"GO_REGULATION_OF_OVARIAN_FOLLICLE_DEVELOPMENT","pval":0.27097,"padj":0.83739,"ES":0.94607,"NES":1.30139,"nMoreExtreme":14337,"size":5,"leadingEdge":["SRC","AMH"]} {"pathway":"GO_REGULATION_OF_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY","pval":0.08662,"padj":0.65354,"ES":0.86369,"NES":1.30135,"nMoreExtreme":6045,"size":47,"leadingEdge":["HLA-E","C3","LYN","PTAFR","DDX58","FCER1G","CD84","TICAM1","FGR"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MACROPHAGE_CYTOKINE_PRODUCTION","pval":0.27118,"padj":0.83739,"ES":0.94601,"NES":1.30132,"nMoreExtreme":14348,"size":5,"leadingEdge":["TGFB1","IRAK3"]} {"pathway":"GO_MICROGLIA_DIFFERENTIATION","pval":0.27118,"padj":0.83739,"ES":0.94601,"NES":1.30132,"nMoreExtreme":14348,"size":5,"leadingEdge":["TGFB1","TSPAN2"]} {"pathway":"GO_MAMMARY_GLAND_BRANCHING_INVOLVED_IN_THELARCHE","pval":0.27118,"padj":0.83739,"ES":0.94601,"NES":1.30132,"nMoreExtreme":14348,"size":5,"leadingEdge":["TGFB1","AREG"]} {"pathway":"GO_BRANCH_ELONGATION_INVOLVED_IN_MAMMARY_GLAND_DUCT_BRANCHING","pval":0.27118,"padj":0.83739,"ES":0.94601,"NES":1.30132,"nMoreExtreme":14348,"size":5,"leadingEdge":["TGFB1","ESR1"]} {"pathway":"GO_REGULATION_OF_MACROPHAGE_ACTIVATION","pval":0.0846,"padj":0.65213,"ES":0.8588,"NES":1.30122,"nMoreExtreme":5935,"size":49,"leadingEdge":["IL31RA","CD74","LRRK2","ZC3H12A","STAP1","IL6","TNF","PTPRC","NR1H3","SLC7A2","CCL3","CX3CL1","IL33"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY","pval":0.04096,"padj":0.51837,"ES":0.77483,"NES":1.30112,"nMoreExtreme":3326,"size":123,"leadingEdge":["AIM2","TNFSF10","JAK2","RIPK2","FAS","BCL2L11","PML","MEFV","CASP4","PMAIP1","CASP10","TNF","CASP5","F3","ROBO1","CASP1","NKX3-1","BBC3","SMAD3","BAK1","NGF"]} {"pathway":"GO_NATURAL_KILLER_CELL_DEGRANULATION","pval":0.02029,"padj":0.36159,"ES":0.99466,"NES":1.3011,"nMoreExtreme":1102,"size":7,"leadingEdge":["HLA-F","RAB27A"]} {"pathway":"GO_REGULATION_OF_METAL_ION_TRANSPORT","pval":0.01335,"padj":0.29795,"ES":0.73355,"NES":1.30036,"nMoreExtreme":1216,"size":278,"leadingEdge":["ATP1B2","P2RX7","CXCL11","PDE4B","CXCL10","SLC31A2","CXCL9","AGT","KCNJ2","CAMK2D","SPTBN4","ICAM1","PML","SRI","B2M","P2RX4","LILRA2","ANK2","DYSF","CCL5","LYN","KCNE5","RNF207","STAC3","JPH4","SLC8A1","CXCL12","GEM","CCL4","LILRB1","KCNE1","PSEN2","CCL2","P2RY12","TGFB1","ACTN2","PTGS2","CCL3","CX3CL1","RGS9","MIR212","SPINK1","CLIC2","PDGFB","GLRX","KCNE1B","BAK1","STOM","SIK1","LILRA5","S100A1","CCR1","KCNMB1","GPR35","HAP1","CD84","ADORA2A"]} {"pathway":"GO_NONASSOCIATIVE_LEARNING","pval":0.44149,"padj":0.90167,"ES":0.91304,"NES":1.30021,"nMoreExtreme":22977,"size":4,"leadingEdge":["MAPK8IP2","DGKI"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELL_VOLUME","pval":0.2763,"padj":0.83968,"ES":0.94512,"NES":1.30008,"nMoreExtreme":14619,"size":5,"leadingEdge":["P2RX7","KCNMA1"]} {"pathway":"GO_RESPONSE_TO_INTERLEUKIN_3","pval":0.12879,"padj":0.72213,"ES":0.9718,"NES":1.29946,"nMoreExtreme":6911,"size":6,"leadingEdge":["IL3RA","CSF2RB","MT2A","GSK3B"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS","pval":0.02996,"padj":0.43424,"ES":0.96407,"NES":1.29917,"nMoreExtreme":1884,"size":23,"leadingEdge":["AGT","CAMK2D","IL12A","SOD2","MAP2K4"]} {"pathway":"GO_O_GLYCAN_PROCESSING","pval":0.09654,"padj":0.66591,"ES":0.88641,"NES":1.29904,"nMoreExtreme":6556,"size":39,"leadingEdge":["MUC1","GCNT3","B4GALT5","GALNT12","ST6GALNAC2","GALNT3","GCNT1"]} {"pathway":"GO_AXON_CHOICE_POINT_RECOGNITION","pval":0.28208,"padj":0.84486,"ES":0.94416,"NES":1.29877,"nMoreExtreme":14925,"size":5,"leadingEdge":["ROBO1","EFNB3"]} {"pathway":"GO_AGGRESOME_ASSEMBLY","pval":0.13177,"padj":0.72756,"ES":0.97125,"NES":1.29873,"nMoreExtreme":7071,"size":6,"leadingEdge":["UBD","HDAC6"]} {"pathway":"GO_ARGININE_BIOSYNTHETIC_PROCESS","pval":0.44828,"padj":0.90517,"ES":0.91186,"NES":1.29853,"nMoreExtreme":23330,"size":4,"leadingEdge":["ASS1","CPS1"]} {"pathway":"GO_VERY_LOW_DENSITY_LIPOPROTEIN_PARTICLE_ASSEMBLY","pval":0.13302,"padj":0.72971,"ES":0.97107,"NES":1.29849,"nMoreExtreme":7138,"size":6,"leadingEdge":["SOAT1","ACSL3"]} {"pathway":"GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_ENDOGENOUS_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_I_VIA_ER_PATHWAY","pval":0.13406,"padj":0.72971,"ES":0.97084,"NES":1.29819,"nMoreExtreme":7194,"size":6,"leadingEdge":["HLA-F","HLA-B","HLA-E","HLA-A","HLA-C","HLA-G"]} {"pathway":"GO_DETECTION_OF_LIGHT_STIMULUS","pval":0.10235,"padj":0.67367,"ES":0.90118,"NES":1.29798,"nMoreExtreme":6821,"size":35,"leadingEdge":["CDS1","GUCA1A","PLEKHB1"]} {"pathway":"GO_GROOMING_BEHAVIOR","pval":0.13538,"padj":0.73185,"ES":0.97062,"NES":1.29789,"nMoreExtreme":7265,"size":6,"leadingEdge":["CTNS","HOXB8"]} {"pathway":"GO_REGULATION_OF_CALCIUM_ION_TRANSPORT","pval":0.0284,"padj":0.42056,"ES":0.74969,"NES":1.29771,"nMoreExtreme":2446,"size":183,"leadingEdge":["P2RX7","CXCL11","PDE4B","CXCL10","CXCL9","AGT","CAMK2D","ICAM1","PML","SRI","P2RX4","LILRA2","ANK2","DYSF","CCL5","LYN","STAC3","JPH4","SLC8A1","CXCL12","GEM","CCL4","LILRB1","PSEN2","CCL2","P2RY12","TGFB1","PTGS2","CCL3","CX3CL1","RGS9","SPINK1","CLIC2","PDGFB","BAK1","LILRA5","S100A1","CCR1","GPR35","HAP1","CD84","ADORA2A"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MACROPHAGE_DIFFERENTIATION","pval":0.28749,"padj":0.84886,"ES":0.94326,"NES":1.29753,"nMoreExtreme":15211,"size":5,"leadingEdge":["PTPN2","C1QC","INHBA"]} {"pathway":"GO_REGULATION_OF_ANIMAL_ORGAN_MORPHOGENESIS","pval":0.02213,"padj":0.376,"ES":0.74197,"NES":1.29749,"nMoreExtreme":1949,"size":215,"leadingEdge":["PSME2","PSMB9","CEACAM1","HGF","PSME1","STAT1","PSMB10","AGT","PIM1","PSMB8","EDN1","CSF1","TNFAIP3","RNF207","FGF10","TNF","SOX8","PSMA4","PSMA2","HPN","TGFB1","ROBO1","PSMA5","FOXC1","CFLAR","GATA3"]} {"pathway":"GO_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY","pval":0.04359,"padj":0.52235,"ES":0.773,"NES":1.29732,"nMoreExtreme":3536,"size":122,"leadingEdge":["CD40","P2RX7","IL12RB1","LAG3","TBX21","HLA-F","CEACAM1","HLA-B","HLA-E","HLA-A","HLA-C","B2M","C3","SLAMF6","RSAD2","HLA-G","BCL6","IL12A","LTA","PARP3","IL6","TNF","SERPINB9","CD226","RASGRP1","PTPRC","LILRB1","TGFB1"]} {"pathway":"GO_STRIATED_MUSCLE_CELL_APOPTOTIC_PROCESS","pval":0.06936,"padj":0.61494,"ES":0.92845,"NES":1.29714,"nMoreExtreme":4500,"size":29,"leadingEdge":["JAK2","AGT","CAMK2D","CFLAR","NFE2L2","HSPB6"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SCHWANN_CELL_PROLIFERATION","pval":0.2899,"padj":0.85125,"ES":0.94291,"NES":1.29704,"nMoreExtreme":15339,"size":5,"leadingEdge":["ASCL2","RNF10"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE","pval":0.06261,"padj":0.59455,"ES":0.80464,"NES":1.297,"nMoreExtreme":4756,"size":81,"leadingEdge":["CD40","CD74","TBX21","NOD2","HLA-F","HLA-E","B2M","RSAD2","HLA-G","NR4A3","TNFRSF14","IL6","SEMA7A","CD226","PTPRC","DDX58","LILRB1","TGFB1","GATA3","IL33"]} {"pathway":"GO_RESPONSE_TO_INTERFERON_BETA","pval":0.05568,"padj":0.56688,"ES":0.93897,"NES":1.297,"nMoreExtreme":3579,"size":27,"leadingEdge":["IRF1","AIM2","ACOD1","STAT1","IFITM2","IFITM1","XAF1","IFITM3","PYHIN1","PLSCR1","TLR3","MNDA","IKBKE"]} {"pathway":"GO_PROTEIN_PALMITOYLATION","pval":0.09157,"padj":0.66294,"ES":0.91358,"NES":1.29659,"nMoreExtreme":6021,"size":32,"leadingEdge":["ZDHHC19","GLUL","ZDHHC18","ZDHHC11B","ZDHHC23","ZDHHC6"]} {"pathway":"GO_NLS_BEARING_PROTEIN_IMPORT_INTO_NUCLEUS","pval":0.0273,"padj":0.41718,"ES":0.96834,"NES":1.29643,"nMoreExtreme":1707,"size":22,"leadingEdge":["KPNA5","RGPD5"]} {"pathway":"GO_NCRNA_CATABOLIC_PROCESS","pval":0.07175,"padj":0.62112,"ES":0.92766,"NES":1.29604,"nMoreExtreme":4655,"size":29,"leadingEdge":["XRN1","ZC3H12A","LIN28A"]} {"pathway":"GO_MONONUCLEAR_CELL_DIFFERENTIATION","pval":0.09289,"padj":0.66428,"ES":0.91314,"NES":1.29596,"nMoreExtreme":6108,"size":32,"leadingEdge":["IL31RA","CD74","IRF7","CSF1","MT1G"]} {"pathway":"GO_COLLATERAL_SPROUTING_IN_ABSENCE_OF_INJURY","pval":0.45967,"padj":0.90517,"ES":0.90979,"NES":1.29557,"nMoreExtreme":23923,"size":4,"leadingEdge":["COBL","WNT3"]} {"pathway":"GO_REGULATION_OF_LEUKOCYTE_DEGRANULATION","pval":0.09873,"padj":0.66699,"ES":0.88074,"NES":1.29526,"nMoreExtreme":6729,"size":40,"leadingEdge":["HLA-F","CEACAM1","LYN","PTAFR","FCER1G","CD84","FGR"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INTERLEUKIN_12_BIOSYNTHETIC_PROCESS","pval":0.29705,"padj":0.85691,"ES":0.94159,"NES":1.29523,"nMoreExtreme":15717,"size":5,"leadingEdge":["IRF1","LTB","TLR4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MYELOID_CELL_APOPTOTIC_PROCESS","pval":0.0397,"padj":0.51131,"ES":0.99011,"NES":1.29514,"nMoreExtreme":2157,"size":7,"leadingEdge":["HCAR2","PIK3CB"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE","pval":0.07916,"padj":0.63606,"ES":0.83216,"NES":1.2951,"nMoreExtreme":5737,"size":60,"leadingEdge":["GBP1","ATF3","KLF4","BTN2A2","MIR503","LYN","DUSP10","PTPRC","PTPN2","PTPN1","TLR4"]} {"pathway":"GO_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_ALPHA_SIGNALING_PATHWAY","pval":0.29765,"padj":0.85717,"ES":0.94146,"NES":1.29506,"nMoreExtreme":15749,"size":5,"leadingEdge":["PDGFRA","PHF14"]} {"pathway":"GO_PARATHYROID_GLAND_DEVELOPMENT","pval":0.46175,"padj":0.90517,"ES":0.90939,"NES":1.29501,"nMoreExtreme":24031,"size":4,"leadingEdge":["GATA3","TBX1","CRKL"]} {"pathway":"GO_HISTAMINE_PRODUCTION_INVOLVED_IN_INFLAMMATORY_RESPONSE","pval":0.14884,"padj":0.75093,"ES":0.96809,"NES":1.29451,"nMoreExtreme":7987,"size":6,"leadingEdge":["LYN","BTK"]} {"pathway":"GO_L_THREONINE_CATABOLIC_PROCESS_TO_GLYCINE","pval":0.46432,"padj":0.90533,"ES":0.90894,"NES":1.29437,"nMoreExtreme":24165,"size":4,"leadingEdge":["SDSL","SDS","GCAT"]} {"pathway":"GO_TRICARBOXYLIC_ACID_CYCLE","pval":0.09724,"padj":0.66591,"ES":0.91178,"NES":1.29403,"nMoreExtreme":6394,"size":32,"leadingEdge":["SDHB","MDH1"]} {"pathway":"GO_MYD88_INDEPENDENT_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY","pval":0.09738,"padj":0.66591,"ES":0.91174,"NES":1.29397,"nMoreExtreme":6403,"size":32,"leadingEdge":["CD300LF","IRF7","TICAM2","TANK","BIRC3","TLR3","IKBKE","TLR4","TICAM1","SARM1"]} {"pathway":"GO_GLUTATHIONE_CATABOLIC_PROCESS","pval":0.1518,"padj":0.75292,"ES":0.96753,"NES":1.29375,"nMoreExtreme":8146,"size":6,"leadingEdge":["GGT5","CHAC1","GGT1"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_ANTIBIOTIC","pval":0.04516,"padj":0.53297,"ES":0.77038,"NES":1.29364,"nMoreExtreme":3667,"size":123,"leadingEdge":["IL18BP","LRRK2","HGF","CCL7","XRN1","KLF4","ZC3H12A","NR4A3","TNFAIP3","IL6","TXN","PLA2G4A","SMPD3","SRC","NFE2L2","PDGFB","IL18RAP","KCNMB1","ZNF277","MET"]} {"pathway":"GO_CEREBELLAR_GRANULAR_LAYER_FORMATION","pval":0.46741,"padj":0.90738,"ES":0.90832,"NES":1.29349,"nMoreExtreme":24326,"size":4,"leadingEdge":["PROX1","OPHN1"]} {"pathway":"GO_LENS_FIBER_CELL_MORPHOGENESIS","pval":0.46741,"padj":0.90738,"ES":0.90832,"NES":1.29349,"nMoreExtreme":24326,"size":4,"leadingEdge":["PROX1","TBC1D20"]} {"pathway":"GO_GLUTAMATE_CATABOLIC_PROCESS","pval":0.15329,"padj":0.75344,"ES":0.9673,"NES":1.29345,"nMoreExtreme":8226,"size":6,"leadingEdge":["GLUL","GOT1"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_DRUG","pval":0.01334,"padj":0.29795,"ES":0.7276,"NES":1.29344,"nMoreExtreme":1224,"size":295,"leadingEdge":["IL18BP","AIM2","P2RX7","LRRK2","PDE4B","NOD2","HGF","ACOD1","RIPK2","CCL7","XRN1","ICAM1","KLF4","ZC3H12A","P2RX4","EDN1","MT2A","CD69","SLAMF8","PPM1E","NR4A3","TNFAIP3","IL6","TLR3","TXN","TNF","SLC8A1","SMPD3","NCOA1","PTAFR","P2RY12","GCLC","SRC","TGFB1","P2RY2","PTGS2","GAS6","GUCY1B1","CFLAR","NKX3-1","NFE2L2","PLCB1","PDGFB"]} {"pathway":"GO_GANGLIOSIDE_CATABOLIC_PROCESS","pval":0.30512,"padj":0.86182,"ES":0.94017,"NES":1.29328,"nMoreExtreme":16144,"size":5,"leadingEdge":["GM2A","HEXB"]} {"pathway":"GO_ORGANIC_ACID_CATABOLIC_PROCESS","pval":0.0275,"padj":0.41718,"ES":0.74351,"NES":1.29328,"nMoreExtreme":2393,"size":197,"leadingEdge":["IDO1","IDO2","IL4I1","ACOT4","GLUL","KYNU","SDSL","DECR1","KMO","HPD","MMAA","NAGK","GLS","ACBD5","CPT1A","SDS"]} {"pathway":"GO_PROGESTERONE_METABOLIC_PROCESS","pval":0.15465,"padj":0.75685,"ES":0.96706,"NES":1.29313,"nMoreExtreme":8299,"size":6,"leadingEdge":["DHRS9","CYP46A1"]} {"pathway":"GO_SELECTIVE_AUTOPHAGY","pval":0.09394,"padj":0.66439,"ES":0.85811,"NES":1.29295,"nMoreExtreme":6556,"size":47,"leadingEdge":["CALCOCO2","OPTN","RIPK2","STBD1"]} {"pathway":"GO_PRESYNAPTIC_ACTIVE_ZONE_ORGANIZATION","pval":0.04649,"padj":0.53858,"ES":0.98843,"NES":1.29294,"nMoreExtreme":2526,"size":7,"leadingEdge":["ERC2","RAB3A"]} {"pathway":"GO_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS","pval":0.08261,"padj":0.64653,"ES":0.83652,"NES":1.29291,"nMoreExtreme":5926,"size":57,"leadingEdge":["SOCS1","NOD2","KLF4","CISH","LYN","FLT1","FPR2","SOCS3","P2RY12","SRC","TGFB1","CCL19","PDGFRA","PDGFB","AGAP2"]} {"pathway":"GO_ARGININE_TRANSMEMBRANE_TRANSPORT","pval":0.30773,"padj":0.86308,"ES":0.93978,"NES":1.29274,"nMoreExtreme":16282,"size":5,"leadingEdge":["AGT","SLC7A2"]} {"pathway":"GO_CDP_CHOLINE_PATHWAY","pval":0.15802,"padj":0.76268,"ES":0.96635,"NES":1.29218,"nMoreExtreme":8480,"size":6,"leadingEdge":["PCYT1A","CDS1","CHKB"]} {"pathway":"GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_CHOLINERGIC","pval":0.47314,"padj":0.90882,"ES":0.90726,"NES":1.29197,"nMoreExtreme":24624,"size":4,"leadingEdge":["ADORA2A","CHRNA3"]} {"pathway":"GO_THORAX_AND_ANTERIOR_ABDOMEN_DETERMINATION","pval":0.47352,"padj":0.90882,"ES":0.90722,"NES":1.29192,"nMoreExtreme":24644,"size":4,"leadingEdge":["TIFAB","NEUROG1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TRANSLATIONAL_INITIATION","pval":0.00832,"padj":0.24036,"ES":0.9919,"NES":1.29181,"nMoreExtreme":505,"size":18,"leadingEdge":["BANK1","TPR"]} {"pathway":"GO_RESPONSE_TO_HYDROGEN_PEROXIDE","pval":0.04978,"padj":0.55243,"ES":0.77376,"NES":1.2916,"nMoreExtreme":4000,"size":115,"leadingEdge":["IL18BP","LRRK2","HGF","STAT1","KLF4","NR4A3","TNFAIP3","IL6","TXN","SLC8A1","SMPD3","SRC","TXNIP","NFE2L2","BAK1","IL18RAP","ZNF277","MET"]} {"pathway":"GO_GLYCOSYL_COMPOUND_CATABOLIC_PROCESS","pval":0.11035,"padj":0.69745,"ES":0.89665,"NES":1.29145,"nMoreExtreme":7354,"size":35,"leadingEdge":["DPYS","TYMP","APOBEC3D","ENPP4","APOBEC3A","APOBEC3G","APOBEC3F","ADA2"]} {"pathway":"GO_IMPORT_INTO_NUCLEUS","pval":0.04294,"padj":0.52235,"ES":0.76187,"NES":1.29117,"nMoreExtreme":3546,"size":137,"leadingEdge":["AGT","PML","ZC3H12A","KPNA5","STAT3","TGFB1","TXNIP","PTGS2","SMAD3","PRICKLE1"]} {"pathway":"GO_HEME_BIOSYNTHETIC_PROCESS","pval":0.02131,"padj":0.36805,"ES":0.9779,"NES":1.29104,"nMoreExtreme":1316,"size":20,"leadingEdge":["ALAS1","COX10"]} {"pathway":"GO_RETINAL_BIPOLAR_NEURON_DIFFERENTIATION","pval":0.47758,"padj":0.91323,"ES":0.90647,"NES":1.29085,"nMoreExtreme":24855,"size":4,"leadingEdge":["PTN","CABP4"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MACROAUTOPHAGY","pval":0.0906,"padj":0.66096,"ES":0.91904,"NES":1.2908,"nMoreExtreme":5905,"size":30,"leadingEdge":["LRRK2","NPC1","LZTS1","POLDIP2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_LEUKOCYTE_MIGRATION","pval":0.05515,"padj":0.56469,"ES":0.78027,"NES":1.29077,"nMoreExtreme":4367,"size":104,"leadingEdge":["CD74","CXCL10","CCL7","ICAM1","TNFSF18","CCL8","P2RX4","EDN1","VEGFC","DYSF","CCL5","IL12A","CSF1","TNFRSF14","IL6","TNF","CAMK1D","CCL1","CXCL12","PTAFR","CCL4","FPR2","P2RY12","TGFB1","CCL19","CCR6","CXCL8","RIPOR2","GAS6","CCL3","DAPK2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PERK_MEDIATED_UNFOLDED_PROTEIN_RESPONSE","pval":0.31682,"padj":0.86626,"ES":0.93832,"NES":1.29073,"nMoreExtreme":16763,"size":5,"leadingEdge":["PTPN1","NCK2"]} {"pathway":"GO_RESPONSE_TO_INTERLEUKIN_17","pval":0.31803,"padj":0.86728,"ES":0.93809,"NES":1.29042,"nMoreExtreme":16827,"size":5,"leadingEdge":["IL17C","TRIM32"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEOLYSIS","pval":0.01286,"padj":0.29052,"ES":0.72433,"NES":1.29029,"nMoreExtreme":1186,"size":308,"leadingEdge":["PSME2","AIM2","LRRK2","TNFSF10","PSME1","JAK2","NUB1","RIPK2","FAS","BCL2L11","PML","RNF19B","MEFV","ZC3H12A","CASP4","PMAIP1","LYN","PYHIN1","TANK","EDEM1","RNF144B","CASP10","TNF","HPN","CASP5","F3","STAT3","GCLC","SRC","ROBO1","AKIRIN2","CTSC","PLGRKT","PRELID1","CFLAR","CASP1","NKX3-1","NFE2L2","IL33","HERPUD1","BBC3","SMAD3","BAK1","NUPR1","RNF19A","NGF"]} {"pathway":"GO_KILLING_OF_CELLS_OF_OTHER_ORGANISM","pval":0.01649,"padj":0.33082,"ES":0.98398,"NES":1.29027,"nMoreExtreme":1012,"size":19,"leadingEdge":["APOL1","P2RX7","CCL13","BCL2L11","BAD"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MUCUS_SECRETION","pval":0.3192,"padj":0.86901,"ES":0.93792,"NES":1.29019,"nMoreExtreme":16889,"size":5,"leadingEdge":["P2RY2","CYBA"]} {"pathway":"GO_REGULATION_OF_POTASSIUM_ION_IMPORT","pval":0.00169,"padj":0.0907,"ES":0.99955,"NES":1.29013,"nMoreExtreme":92,"size":8,"leadingEdge":["ATP1B2","WNK1"]} {"pathway":"GO_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS","pval":0.00031,"padj":0.02801,"ES":0.70623,"NES":1.2899,"nMoreExtreme":30,"size":822,"leadingEdge":["APOL1","TAP2","TAP1","CD74","P2RX7","CALCOCO2","HLA-DRA","PSMB9","LAMP3","CCL13","CFH","ISG20","STAT1","PSMB10","IFI27","STAT2","PSMB8","IFITM2","ICAM1","BCL2L11","APOBEC3D","IFITM1","CD80","GSDMD","TRIM22","PML","B2M","CCL8","APOBEC3A","APOBEC3G","ZC3H12A","PARP10","SP110","IRF7","RSAD2","USP6NL","IFIH1","SLAMF1","TRIM31","IFITM3","CHMP4C","DYNLT1","KPNA5","CCL5","LYN","IFIT5","LTA","HAVCR1","VRK2","TNFRSF14","TANK","OAS3","PLSCR1","APOBEC3F","IL2RG","TNF","PSMA4","HPN","SERPINB9","RBCK1","CUL1","CD86","CCR5","CCL1","CXCL12","MX1","DDX58","CCL4","CCL2","STAT3","ITGB7","DHX58","SRC","TGFB1","TBKBP1","CGAS","CXCL8","UVRAG","PDGFRA","TRIM21","ADAR","IKBKE","GUCY1A1","NFKBIA","LIG4","ISG15","GAS6","CCL3","TRIM25","CFLAR"]} {"pathway":"GO_POSITIVE_REGULATION_OF_AUTOPHAGY","pval":0.05356,"padj":0.56014,"ES":0.77603,"NES":1.28958,"nMoreExtreme":4272,"size":109,"leadingEdge":["CALCOCO2","LRRK2","OPTN","RIPK2","BCL2L11","TRIM22","MEFV","ZC3H12A","RALB","RUFY4","UVRAG","TRIM21","PLEKHF1"]} {"pathway":"GO_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY","pval":0.04855,"padj":0.5476,"ES":0.76826,"NES":1.28935,"nMoreExtreme":3938,"size":122,"leadingEdge":["IRF1","ACOD1","RIPK2","TLR8","CD300LF","TLR10","CTSS","IRF7","RSAD2","LILRA2","LYN","TLR7","TICAM2","TANK","CTSL","IRF4","TNFAIP3","LILRA4","BIRC3","MYD88","TLR3","PIK3AP1","NR1H3","WDFY1","IKBKE","NFKBIA","TREML4","OTUD4"]} {"pathway":"GO_TRNA_PROCESSING","pval":0.04777,"padj":0.54541,"ES":0.76663,"NES":1.28934,"nMoreExtreme":3891,"size":125,"leadingEdge":["SEPHS2","TSEN34","ELAC2"]} {"pathway":"GO_INTERLEUKIN_3_MEDIATED_SIGNALING_PATHWAY","pval":0.32371,"padj":0.86974,"ES":0.93728,"NES":1.2893,"nMoreExtreme":17128,"size":5,"leadingEdge":["IL3RA","CSF2RB","FCER1G"]} {"pathway":"GO_NEURON_FATE_DETERMINATION","pval":0.48363,"padj":0.91689,"ES":0.90535,"NES":1.28925,"nMoreExtreme":25170,"size":4,"leadingEdge":["WNT1","HES1"]} {"pathway":"GO_CLUSTERING_OF_VOLTAGE_GATED_SODIUM_CHANNELS","pval":0.16911,"padj":0.77295,"ES":0.96416,"NES":1.28925,"nMoreExtreme":9075,"size":6,"leadingEdge":["GLDN","SPTBN4","NRCAM"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MONOCYTE_CHEMOTACTIC_PROTEIN_1_PRODUCTION","pval":0.0595,"padj":0.58367,"ES":0.98556,"NES":1.28919,"nMoreExtreme":3233,"size":7,"leadingEdge":["MCOLN2","TRPV4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY","pval":0.32443,"padj":0.86994,"ES":0.93714,"NES":1.28911,"nMoreExtreme":17166,"size":5,"leadingEdge":["MCL1","FBXW7"]} {"pathway":"GO_NEURONAL_ACTION_POTENTIAL_PROPAGATION","pval":0.16983,"padj":0.77295,"ES":0.96404,"NES":1.2891,"nMoreExtreme":9114,"size":6,"leadingEdge":["NRCAM","SCN1B"]} {"pathway":"GO_NEUROLOGICAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE","pval":0.17023,"padj":0.77295,"ES":0.96399,"NES":1.28902,"nMoreExtreme":9135,"size":6,"leadingEdge":["AGT","SOD2"]} {"pathway":"GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL_INVOLVED_IN_REGULATION_OF_CONTRACTION","pval":0.06023,"padj":0.58568,"ES":0.98539,"NES":1.28897,"nMoreExtreme":3273,"size":7,"leadingEdge":["CAMK2D","CAV1"]} {"pathway":"GO_PORPHYRIN_CONTAINING_COMPOUND_METABOLIC_PROCESS","pval":0.06178,"padj":0.59283,"ES":0.98506,"NES":1.28853,"nMoreExtreme":3357,"size":7,"leadingEdge":["CYP1A1","FECH"]} {"pathway":"GO_GPI_ANCHOR_BIOSYNTHETIC_PROCESS","pval":0.09547,"padj":0.66591,"ES":0.91736,"NES":1.28844,"nMoreExtreme":6223,"size":30,"leadingEdge":["PIGY","DPM1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_STEM_CELL_POPULATION_MAINTENANCE","pval":0.48786,"padj":0.91689,"ES":0.90462,"NES":1.28821,"nMoreExtreme":25390,"size":4,"leadingEdge":["HNF1B","ZNF706"]} {"pathway":"GO_KETONE_CATABOLIC_PROCESS","pval":0.17416,"padj":0.77529,"ES":0.96326,"NES":1.28805,"nMoreExtreme":9346,"size":6,"leadingEdge":["CBR3","KYNU","HAGH"]} {"pathway":"GO_PROTEIN_PROCESSING_INVOLVED_IN_PROTEIN_TARGETING_TO_MITOCHONDRION","pval":0.00815,"padj":0.23818,"ES":0.99753,"NES":1.28752,"nMoreExtreme":448,"size":8,"leadingEdge":["LRRK2","MIPEP"]} {"pathway":"GO_POSITIVE_REGULATION_OF_DEACETYLASE_ACTIVITY","pval":0.00815,"padj":0.23818,"ES":0.99753,"NES":1.28752,"nMoreExtreme":448,"size":8,"leadingEdge":["LRRK2","PRKD2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_EXCITATORY_POSTSYNAPTIC_POTENTIAL","pval":0.00815,"padj":0.23818,"ES":0.99753,"NES":1.28752,"nMoreExtreme":448,"size":8,"leadingEdge":["LRRK2","MTMR2"]} {"pathway":"GO_SEROTONIN_UPTAKE","pval":0.33193,"padj":0.87332,"ES":0.93585,"NES":1.28733,"nMoreExtreme":17563,"size":5,"leadingEdge":["SLC18A1","GPM6B","NOS1"]} {"pathway":"GO_REGULATION_OF_KILLING_OF_CELLS_OF_OTHER_ORGANISM","pval":0.06654,"padj":0.60375,"ES":0.98388,"NES":1.28699,"nMoreExtreme":3616,"size":7,"leadingEdge":["P2RX7","BCL2L11","BAD"]} {"pathway":"GO_DISRUPTION_OF_CELLS_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION","pval":0.06669,"padj":0.60375,"ES":0.98382,"NES":1.28691,"nMoreExtreme":3624,"size":7,"leadingEdge":["BCL2L11","BAD"]} {"pathway":"GO_POSITIVE_REGULATION_OF_FIBROBLAST_APOPTOTIC_PROCESS","pval":0.06669,"padj":0.60375,"ES":0.98382,"NES":1.28691,"nMoreExtreme":3624,"size":7,"leadingEdge":["BCL2L11","BID"]} {"pathway":"GO_RRNA_MODIFICATION","pval":0.11739,"padj":0.70191,"ES":0.89765,"NES":1.28689,"nMoreExtreme":7792,"size":34,"leadingEdge":["BMT2","TSR3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MHC_CLASS_II_BIOSYNTHETIC_PROCESS","pval":0.17947,"padj":0.77529,"ES":0.96233,"NES":1.28681,"nMoreExtreme":9631,"size":6,"leadingEdge":["CIITA","TLR4"]} {"pathway":"GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY","pval":0.04361,"padj":0.52235,"ES":0.75644,"NES":1.28667,"nMoreExtreme":3627,"size":144,"leadingEdge":["CD74","LRRK2","BCL2A1","BCL2L11","MUC1","CYLD","PMAIP1","SOD2","CXCL12","PTPN2","SRC","PTPN1","GRINA","MCL1","PLEKHF1","PTGS2","NKX3-1","NFE2L2","HERPUD1","DAPK2"]} {"pathway":"GO_REGULATION_OF_PROSTAGLANDIN_BIOSYNTHETIC_PROCESS","pval":0.3356,"padj":0.87575,"ES":0.93528,"NES":1.28656,"nMoreExtreme":17757,"size":5,"leadingEdge":["PTGS2","PIBF1"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_LEAD_ION","pval":0.3356,"padj":0.87575,"ES":0.93528,"NES":1.28656,"nMoreExtreme":17757,"size":5,"leadingEdge":["PTGS2","ALAD"]} {"pathway":"GO_REGULATION_OF_CELLULAR_RESPONSE_TO_OSMOTIC_STRESS","pval":0.3356,"padj":0.87575,"ES":0.93528,"NES":1.28656,"nMoreExtreme":17757,"size":5,"leadingEdge":["PTGS2","BAD"]} {"pathway":"GO_POSITIVE_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY","pval":0.05612,"padj":0.56982,"ES":0.77382,"NES":1.28592,"nMoreExtreme":4476,"size":109,"leadingEdge":["CD40","P2RX7","IL12RB1","LAG3","TBX21","NOD2","HLA-F","HLA-B","HLA-E","HLA-A","HLA-C","B2M","C3","SLAMF6","RSAD2","HLA-G","IL12A","LTA","IL6","TNF","CD226","RASGRP1","PTPRC","PTAFR","DDX58","TGFB1"]} {"pathway":"GO_P38MAPK_CASCADE","pval":0.10939,"padj":0.69587,"ES":0.87736,"NES":1.28578,"nMoreExtreme":7429,"size":39,"leadingEdge":["HGF","ZC3H12A","CYLD","NCF1","GADD45B","GADD45G","DUSP10","ZFP36"]} {"pathway":"GO_RENAL_WATER_TRANSPORT","pval":0.33938,"padj":0.87818,"ES":0.93467,"NES":1.28571,"nMoreExtreme":17957,"size":5,"leadingEdge":["HAS2","HYAL2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_GLYCOSYLATION","pval":0.01376,"padj":0.3051,"ES":0.99601,"NES":1.28556,"nMoreExtreme":757,"size":8,"leadingEdge":["IL15","POMT2"]} {"pathway":"GO_ALPHA_AMINO_ACID_CATABOLIC_PROCESS","pval":0.08837,"padj":0.65704,"ES":0.8295,"NES":1.2855,"nMoreExtreme":6364,"size":58,"leadingEdge":["IDO1","IDO2","GLUL","KYNU","SDSL","KMO","HPD","GLS","SDS"]} {"pathway":"GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_IV_ASSEMBLY","pval":0.02771,"padj":0.41718,"ES":0.97352,"NES":1.28525,"nMoreExtreme":1712,"size":20,"leadingEdge":["SCO2","BCS1L"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS","pval":0.04163,"padj":0.51963,"ES":0.95996,"NES":1.28521,"nMoreExtreme":2604,"size":22,"leadingEdge":["LILRB4","POLR1A"]} {"pathway":"GO_LIPOSACCHARIDE_METABOLIC_PROCESS","pval":0.10349,"padj":0.67471,"ES":0.85818,"NES":1.28486,"nMoreExtreme":7184,"size":45,"leadingEdge":["SMPD3","GM2A","HEXB"]} {"pathway":"GO_DEMETHYLATION","pval":0.08962,"padj":0.65989,"ES":0.83122,"NES":1.28471,"nMoreExtreme":6429,"size":57,"leadingEdge":["CYP1A1","APOBEC3D","APOBEC3A","APOBEC3G","APOBEC3F","OTUD4","GATA3","KDM1B"]} {"pathway":"GO_INFLAMMATORY_RESPONSE","pval":0.00276,"padj":0.12122,"ES":0.70782,"NES":1.2847,"nMoreExtreme":267,"size":553,"leadingEdge":["GBP5","APOL3","IL31RA","IDO1","AIM2","CD40","C4A","P2RX7","CIITA","LRRK2","CXCL11","C4B","IL15","APOL2","CXCL10","NOD2","ADGRE5","CCL13","HGF","HLA-E","ACOD1","CXCL9","NMI","JAK2","SUCNR1","AGT","RIPK2","TLR8","CCL7","IL27","VCAM1","ICAM1","KLF4","CCL15","TGM2","GSDMD","CCL8","C3","MEFV","TLR10","ZC3H12A","CCRL2","CYLD","CASP4","STAP1","IL1RN","SBNO2","LY75","SLAMF8","POLB","GGT5","PTGER4","RELB","BCL6","CCL18","CCL5","LYN","TNFAIP6","MMP25","TLR7","TICAM2","CSF1","LTA","PLSCR1","TNFAIP3","BIRC3","MYD88","PLA2G4C","IL6","TLR3","SEMA7A","TNF","PTGER2","DUSP10","CD47","RASGRP1","SCN9A","PIK3AP1","CAMK1D","CCR5","CCL1","ITGAL","PTPRC","CHI3L1","PTAFR","CCL4","NR1H3","FPR2","F3","SOCS3","CCL2","STAT3","PTPN2","TGFB1","IL2RA","CCL19","CCR6","CXCL8","NAMPT","SLC7A2","IL17C","NFKBIA","PLGRKT","PTGS2","CHST2","CCL3","CX3CL1","USP18","GATA3","NFE2L2","IL33"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CYTOLYSIS","pval":0.3596,"padj":0.89036,"ES":0.86105,"NES":1.2843,"nMoreExtreme":18070,"size":2,"leadingEdge":["TGFB1","CSF2"]} {"pathway":"GO_CALCIUM_ION_IMPORT","pval":0.0901,"padj":0.66071,"ES":0.83077,"NES":1.28402,"nMoreExtreme":6463,"size":57,"leadingEdge":["DYSF","SLC8A1","CXCL12","PSEN2","CCL2","CACNA1I","CCL3","SPINK1","PDGFB","MCUB"]} {"pathway":"GO_ONE_CARBON_COMPOUND_TRANSPORT","pval":0.50398,"padj":0.91988,"ES":0.90153,"NES":1.28381,"nMoreExtreme":26229,"size":4,"leadingEdge":["AQP9","CA2"]} {"pathway":"GO_LUNG_SACCULE_DEVELOPMENT","pval":0.19171,"padj":0.79001,"ES":0.95994,"NES":1.28361,"nMoreExtreme":10288,"size":6,"leadingEdge":["FGF10","CREB1"]} {"pathway":"GO_GLYCEROL_ETHER_METABOLIC_PROCESS","pval":0.19204,"padj":0.79001,"ES":0.95989,"NES":1.28354,"nMoreExtreme":10306,"size":6,"leadingEdge":["PLAAT3","TXN","TXN2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PROTEIN_EXPORT_FROM_NUCLEUS","pval":0.19236,"padj":0.79001,"ES":0.95983,"NES":1.28346,"nMoreExtreme":10323,"size":6,"leadingEdge":["TXN","SP100"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_T_CELL_PROLIFERATION","pval":0.10479,"padj":0.68014,"ES":0.85722,"NES":1.28342,"nMoreExtreme":7274,"size":45,"leadingEdge":["IDO1","CD274","PDCD1LG2","CD80","BTN2A2","HLA-G","TNFRSF14","CD86","LILRB1","TGFB1","IL2RA"]} {"pathway":"GO_REGULATION_OF_AUTOPHAGY","pval":0.01668,"padj":0.33355,"ES":0.72184,"NES":1.28335,"nMoreExtreme":1530,"size":296,"leadingEdge":["CALCOCO2","LRRK2","LAMP3","HGF","ATP13A2","OPTN","RIPK2","BCL2L11","TRIM22","MEFV","ZC3H12A","DRAM1","RALB","RUFY4","TMEM150A","RMC1","STAT3","UVRAG","ATP6V1A","NAMPT","TRIM21","RRAGC","MCL1","PLEKHF1","DEPP1","RRAGD","DAPK2"]} {"pathway":"GO_RENIN_SECRETION_INTO_BLOOD_STREAM","pval":0.35134,"padj":0.88663,"ES":0.93282,"NES":1.28317,"nMoreExtreme":18590,"size":5,"leadingEdge":["SUCNR1","PCSK5"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_HEART_RATE","pval":0.08005,"padj":0.63881,"ES":0.9809,"NES":1.28309,"nMoreExtreme":4350,"size":7,"leadingEdge":["SPTBN4","SRI","FKBP1B"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NATURAL_KILLER_CELL_CHEMOTAXIS","pval":0.35301,"padj":0.888,"ES":0.93253,"NES":1.28277,"nMoreExtreme":18678,"size":5,"leadingEdge":["CCL7","CCL5","CCL4","CCL3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS","pval":0.08421,"padj":0.65144,"ES":0.92845,"NES":1.28248,"nMoreExtreme":5414,"size":27,"leadingEdge":["JAK2","ZC3H12A","EDN1","CFLAR","NFE2L2","HSPB6"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY","pval":0.08493,"padj":0.65271,"ES":0.92823,"NES":1.28217,"nMoreExtreme":5460,"size":27,"leadingEdge":["MVP","PTPRC","PTPN2","SRCIN1","IBTK"]} {"pathway":"GO_ANTEROGRADE_DENDRITIC_TRANSPORT","pval":0.51111,"padj":0.92419,"ES":0.90024,"NES":1.28197,"nMoreExtreme":26600,"size":4,"leadingEdge":["KIF17","TRAK2"]} {"pathway":"GO_PHOSPHATIDYLSERINE_EXPOSURE_ON_APOPTOTIC_CELL_SURFACE","pval":0.35726,"padj":0.89024,"ES":0.93186,"NES":1.28184,"nMoreExtreme":18903,"size":5,"leadingEdge":["XKR6","XKR8","XKR7"]} {"pathway":"GO_TYPE_2_IMMUNE_RESPONSE","pval":0.12338,"padj":0.71263,"ES":0.90312,"NES":1.28174,"nMoreExtreme":8113,"size":32,"leadingEdge":["IL31RA","IDO1","CD74","TBX21","NOD2","RSAD2","BCL6","DENND1B","IL6","CD86","GATA3","IL33","HLX","IFNL1"]} {"pathway":"GO_REGULATION_OF_CHAPERONE_MEDIATED_AUTOPHAGY","pval":0.0251,"padj":0.40148,"ES":0.99303,"NES":1.28172,"nMoreExtreme":1382,"size":8,"leadingEdge":["ATP13A2","CTSA"]} {"pathway":"GO_REGULATION_OF_LYSOSOMAL_PROTEIN_CATABOLIC_PROCESS","pval":0.0251,"padj":0.40148,"ES":0.99303,"NES":1.28172,"nMoreExtreme":1382,"size":8,"leadingEdge":["ATP13A2","VPS35"]} {"pathway":"GO_CELL_DEATH_IN_RESPONSE_TO_OXIDATIVE_STRESS","pval":0.08006,"padj":0.63881,"ES":0.80407,"NES":1.28167,"nMoreExtreme":5987,"size":73,"leadingEdge":["LRRK2","HGF","JAK2","PML","NR4A3","SOD2","TXN","MCL1","NFE2L2","TLR4","MET","WNT1"]} {"pathway":"GO_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE","pval":0.11224,"padj":0.69864,"ES":0.87145,"NES":1.2816,"nMoreExtreme":7650,"size":40,"leadingEdge":["C4A","C4B","SERPING1","C1QB","CFH","CFB","ACOD1","C2","C3","C1S","C1R","LTA","TNF","PTPRC","A2M","C1QC"]} {"pathway":"GO_SODIUM_ION_HOMEOSTASIS","pval":0.05412,"padj":0.56056,"ES":0.95102,"NES":1.28159,"nMoreExtreme":3404,"size":23,"leadingEdge":["ATP1B2","AGT","SLC12A3","NPR1","EDN1","SLC8A1","ADORA2A"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ACTION_POTENTIAL","pval":0.20052,"padj":0.79183,"ES":0.95831,"NES":1.28143,"nMoreExtreme":10761,"size":6,"leadingEdge":["RNF207","SLC9A1"]} {"pathway":"GO_REGULATION_OF_GAMMA_AMINOBUTYRIC_ACID_SECRETION","pval":0.51383,"padj":0.92459,"ES":0.89969,"NES":1.2812,"nMoreExtreme":26742,"size":4,"leadingEdge":["P2RX7","SV2A"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_STRIATED_MUSCLE_CONTRACTION","pval":0.08638,"padj":0.65271,"ES":0.97944,"NES":1.28118,"nMoreExtreme":4694,"size":7,"leadingEdge":["SRI","ZC3H12A","PIK3CG"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_T_HELPER_17_CELL_DIFFERENTIATION","pval":0.08638,"padj":0.65271,"ES":0.97944,"NES":1.28118,"nMoreExtreme":4694,"size":7,"leadingEdge":["TBX21","ZC3H12A","RC3H2"]} {"pathway":"GO_STRIATED_MUSCLE_ATROPHY","pval":0.36162,"padj":0.89036,"ES":0.93124,"NES":1.28099,"nMoreExtreme":19134,"size":5,"leadingEdge":["IL15","CFLAR"]} {"pathway":"GO_PRODUCTION_OF_MOLECULAR_MEDIATOR_INVOLVED_IN_INFLAMMATORY_RESPONSE","pval":0.10204,"padj":0.67367,"ES":0.84542,"NES":1.28095,"nMoreExtreme":7159,"size":49,"leadingEdge":["GBP5","IDO1","NOD2","MEFV","ZC3H12A","SLAMF8","LYN","MYD88","DUSP10","SLC7A2","IL1R2","FCER1G","TLR4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY","pval":0.10604,"padj":0.68361,"ES":0.85268,"NES":1.28085,"nMoreExtreme":7380,"size":46,"leadingEdge":["TNFSF10","ATF3","AGT","PML","CYLD","PMAIP1","RBCK1","PTPRC"]} {"pathway":"GO_CALCIUM_ION_EXPORT_ACROSS_PLASMA_MEMBRANE","pval":0.36265,"padj":0.89036,"ES":0.93107,"NES":1.28076,"nMoreExtreme":19188,"size":5,"leadingEdge":["RGS9","ATP2B1"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_NICOTINE","pval":0.20279,"padj":0.79569,"ES":0.95781,"NES":1.28076,"nMoreExtreme":10883,"size":6,"leadingEdge":["TNF","BAD"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION","pval":0.11615,"padj":0.70006,"ES":0.87773,"NES":1.28067,"nMoreExtreme":7853,"size":38,"leadingEdge":["IL15","KLF4","NPR1","MIR503","IL12A","SOD2","TNFAIP3","CDKN1A"]} {"pathway":"GO_STRIATUM_DEVELOPMENT","pval":0.00446,"padj":0.16609,"ES":0.99655,"NES":1.28023,"nMoreExtreme":266,"size":16,"leadingEdge":["LRRK2","RARB"]} {"pathway":"GO_RESPONSE_TO_STEROL","pval":0.07919,"padj":0.63606,"ES":0.93245,"NES":1.2802,"nMoreExtreme":5066,"size":26,"leadingEdge":["GRAMD1B","CCR5","TGFB1","CCL3","RORA"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_HYDROGEN_PEROXIDE","pval":0.07543,"padj":0.63068,"ES":0.79417,"NES":1.28013,"nMoreExtreme":5730,"size":81,"leadingEdge":["IL18BP","LRRK2","HGF","KLF4","NR4A3","TNFAIP3","IL6","TXN","SMPD3","SRC","NFE2L2","IL18RAP","ZNF277","MET"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION","pval":0.11545,"padj":0.70006,"ES":0.87345,"NES":1.28005,"nMoreExtreme":7841,"size":39,"leadingEdge":["SOCS1","IL12RB1","RIPK2","CD80","CD83","CD86","RUNX1","CCL19","HLX"]} {"pathway":"GO_VIRAL_BUDDING_VIA_HOST_ESCRT_COMPLEX","pval":0.03399,"padj":0.4724,"ES":0.96953,"NES":1.27998,"nMoreExtreme":2100,"size":20,"leadingEdge":["CHMP4C","TSG101"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PEPTIDASE_ACTIVITY","pval":0.0441,"padj":0.5266,"ES":0.74749,"NES":1.27971,"nMoreExtreme":3717,"size":156,"leadingEdge":["C4A","C4B","SERPING1","LAMP3","HGF","AGT","PZP","KLF4","C3","CARD17","CARD16","BIRC3","SERPINB9","SRC","A2M","UBE2Z","IFI6","SH3RF1","PTGS2","GAS6","CFLAR","BIRC7","SERPINB1","SPINK1","HERPUD1","HMSD","NGF","TNFAIP8"]} {"pathway":"GO_CHOLINE_TRANSPORT","pval":0.36894,"padj":0.89036,"ES":0.93006,"NES":1.27937,"nMoreExtreme":19521,"size":5,"leadingEdge":["SLC44A2","SLC44A1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_T_HELPER_2_CELL_CYTOKINE_PRODUCTION","pval":0.37079,"padj":0.89036,"ES":0.92978,"NES":1.27898,"nMoreExtreme":19619,"size":5,"leadingEdge":["RSAD2","IL6","GATA3","PRKCZ"]} {"pathway":"GO_REGULATION_OF_DNA_DEMETHYLATION","pval":0.37113,"padj":0.89036,"ES":0.92972,"NES":1.27891,"nMoreExtreme":19637,"size":5,"leadingEdge":["OTUD4","GATA3","USP9X"]} {"pathway":"GO_MATURATION_OF_5_8S_RRNA","pval":0.09261,"padj":0.66428,"ES":0.92587,"NES":1.2789,"nMoreExtreme":5954,"size":27,"leadingEdge":["ERI1","LAS1L"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INTERLEUKIN_5_SECRETION","pval":0.37155,"padj":0.89036,"ES":0.92967,"NES":1.27883,"nMoreExtreme":19659,"size":5,"leadingEdge":["GATA3","PRKCZ"]} {"pathway":"GO_CELL_PROLIFERATION_INVOLVED_IN_METANEPHROS_DEVELOPMENT","pval":0.03452,"padj":0.47454,"ES":0.99073,"NES":1.27875,"nMoreExtreme":1901,"size":8,"leadingEdge":["STAT1","PDGFRB"]} {"pathway":"GO_MODULATION_OF_PROGRAMMED_CELL_DEATH_IN_OTHER_ORGANISM","pval":0.21131,"padj":0.79831,"ES":0.95629,"NES":1.27873,"nMoreExtreme":11340,"size":6,"leadingEdge":["BCL2L11","SERPINB9","BAD"]} {"pathway":"GO_REGULATION_OF_ACTIN_NUCLEATION","pval":0.08319,"padj":0.64772,"ES":0.93133,"NES":1.27865,"nMoreExtreme":5322,"size":26,"leadingEdge":["SCIN","AP1AR","WAS"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CHOLESTEROL_BIOSYNTHETIC_PROCESS","pval":0.37277,"padj":0.89036,"ES":0.92944,"NES":1.27852,"nMoreExtreme":19724,"size":5,"leadingEdge":["ERLIN1","SCAP"]} {"pathway":"GO_REGULATION_OF_CELL_KILLING","pval":0.08828,"padj":0.65704,"ES":0.81354,"NES":1.27833,"nMoreExtreme":6477,"size":65,"leadingEdge":["P2RX7","IL12RB1","LAG3","HLA-F","CEACAM1","HLA-B","HLA-E","HLA-A","HLA-C","ICAM1","BCL2L11","B2M","SLAMF6","STAP1","HLA-G","IL12A","SERPINB9","CD226","RASGRP1","PTPRC","LILRB1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE","pval":0.06976,"padj":0.61701,"ES":0.78167,"NES":1.2783,"nMoreExtreme":5418,"size":93,"leadingEdge":["CD40","P2RX7","CD274","IL12RB1","TBX21","HLA-F","HLA-B","HLA-E","HLA-A","HLA-C","RIPK2","TNFSF13B","CD80","B2M","C3","RSAD2","HLA-G","IL12A","LTA","IL6","TNF","CD226","PTPRC","TGFB1","CCL19"]} {"pathway":"GO_POTASSIUM_ION_IMPORT_ACROSS_PLASMA_MEMBRANE","pval":0.12604,"padj":0.71891,"ES":0.90528,"NES":1.2779,"nMoreExtreme":8250,"size":31,"leadingEdge":["ATP1B2","KCNJ10","SLC12A3","KCNJ2","KCNJ15","SLC12A7"]} {"pathway":"GO_INHIBITION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS","pval":0.37584,"padj":0.89036,"ES":0.92894,"NES":1.27783,"nMoreExtreme":19886,"size":5,"leadingEdge":["BIRC3","BIRC7","XIAP"]} {"pathway":"GO_PROCESS_UTILIZING_AUTOPHAGIC_MECHANISM","pval":0.0069,"padj":0.21717,"ES":0.70725,"NES":1.27765,"nMoreExtreme":660,"size":453,"leadingEdge":["CALCOCO2","LRRK2","LAMP3","HGF","ATP13A2","OPTN","TRIM17","RIPK2","BCL2L11","TRIM22","MEFV","ZC3H12A","DRAM1","RALB","CHMP4C","RUFY4","TMEM150A","RMC1","RAB24","ATG3","STAT3","SRC","UVRAG","ATP6V1A","NAMPT","TRIM21","RRAGC","C19orf12","MCL1","PLEKHF1","DEPP1","RRAGD","DAPK2","RAB39A","ACBD5","STX17","C9orf72","IRF8","NPC1","STBD1","MET","MTMR8","HAP1","CD84","LZTS1","TICAM1"]} {"pathway":"GO_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL","pval":0.00025,"padj":0.02528,"ES":0.69855,"NES":1.27764,"nMoreExtreme":24,"size":967,"leadingEdge":["UBD","PSME2","SOCS1","LRRK2","PSMB9","FBXO6","NOD2","PSME1","EGR2","NMI","TRIM17","PSMB10","NUB1","IFI27","RIPK2","LONRF1","UBE2L6","PSMB8","STAMBPL1","JADE2","TRIM22","RNF19B","ZC3H12A","PARP10","CYLD","TRIM69","FEM1C","IFIH1","DTX3L","FAM107A","CISH","TRIM31","DYSF","ASB2","POLB","TANK","EPOP","OTUD1","AMER1","TNFAIP3","RNF144B","BIRC3","WSB1","ATXN7","RNF24","PSMA4","PSMA2","SPOPL","RBCK1","CUL1","TRIM72","UBE2A","ATG3","DDX58","VCPIP1","SOCS3","TRIM71","TRIM9","GCLC","PSMA5","TRIM21","ZNRF2","UBE2Z","NFKBIA","ADGRB1","ISG15","SH3RF1","OTUD4","NEURL3","USP18","TRIM25","GATA3","PCGF5","BIRC7","NFE2L2","IL33","CCNA1","HERPUD1","SMAD3"]} {"pathway":"GO_SCF_COMPLEX_ASSEMBLY","pval":0.21658,"padj":0.80167,"ES":0.95539,"NES":1.27753,"nMoreExtreme":11623,"size":6,"leadingEdge":["CUL1","RBX1"]} {"pathway":"GO_T_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE","pval":0.07876,"padj":0.63581,"ES":0.79457,"NES":1.27752,"nMoreExtreme":5962,"size":79,"leadingEdge":["HLA-DMB","IL12RB1","TBX21","CEACAM1","RIPK2","IL27","ICAM1","TNFSF18","CD80","SLAMF6","ZC3H12A","JAK3","PTGER4","RELB","BCL6","IRF4","IL6","CLEC4D","CLEC4E","CD86","ITGAL","LILRB1","STAT3","SEMA4A","CCL19"]} {"pathway":"GO_CARTILAGE_DEVELOPMENT_INVOLVED_IN_ENDOCHONDRAL_BONE_MORPHOGENESIS","pval":0.1236,"padj":0.71278,"ES":0.883,"NES":1.27749,"nMoreExtreme":8279,"size":36,"leadingEdge":["COMP","SMPD3","COCH","COL27A1","HOXA11"]} {"pathway":"GO_TELOMERE_LOCALIZATION","pval":0.21705,"padj":0.80167,"ES":0.95534,"NES":1.27745,"nMoreExtreme":11648,"size":6,"leadingEdge":["MEI1","MLH1"]} {"pathway":"GO_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING","pval":0.12709,"padj":0.72213,"ES":0.90492,"NES":1.2774,"nMoreExtreme":8319,"size":31,"leadingEdge":["SAMD4A","ZFP36","BTG2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_P38MAPK_CASCADE","pval":0.21746,"padj":0.80167,"ES":0.95528,"NES":1.27738,"nMoreExtreme":11670,"size":6,"leadingEdge":["CYLD","DUSP10","DLG1"]} {"pathway":"GO_T_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE","pval":0.0949,"padj":0.6659,"ES":0.82242,"NES":1.277,"nMoreExtreme":6854,"size":59,"leadingEdge":["IL12RB1","TBX21","RIPK2","IL27","CD80","SLAMF6","ZC3H12A","JAK3","PTGER4","RELB","BCL6","IRF4","IL6","CLEC4D","CLEC4E","CD86","STAT3","SEMA4A","CCL19","GATA3","FCER1G","HLX","IFNL1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION","pval":0.3796,"padj":0.89036,"ES":0.92832,"NES":1.27698,"nMoreExtreme":20085,"size":5,"leadingEdge":["NFE2L2","HES1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_HYPOXIA","pval":0.3796,"padj":0.89036,"ES":0.92832,"NES":1.27698,"nMoreExtreme":20085,"size":5,"leadingEdge":["NFE2L2","HIF1A"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY","pval":0.06229,"padj":0.59455,"ES":0.94753,"NES":1.27689,"nMoreExtreme":3918,"size":23,"leadingEdge":["GBP1","CEACAM1","BTN2A2","LILRB4","PTPN2"]} {"pathway":"GO_RESPONSE_TO_ATP","pval":0.08776,"padj":0.65613,"ES":0.92998,"NES":1.27681,"nMoreExtreme":5614,"size":26,"leadingEdge":["P2RX7","SELL","P2RX4","SLC8A1","P2RY12","P2RY2","PTGS2"]} {"pathway":"GO_MACROPHAGE_PROLIFERATION","pval":0.38062,"padj":0.89036,"ES":0.92815,"NES":1.27674,"nMoreExtreme":20139,"size":5,"leadingEdge":["CSF1","CX3CL1","IL33"]} {"pathway":"GO_MICROGLIAL_CELL_PROLIFERATION","pval":0.38062,"padj":0.89036,"ES":0.92815,"NES":1.27674,"nMoreExtreme":20139,"size":5,"leadingEdge":["CSF1","CX3CL1","IL33"]} {"pathway":"GO_SOMATIC_DIVERSIFICATION_OF_T_CELL_RECEPTOR_GENES","pval":0.3809,"padj":0.89036,"ES":0.92814,"NES":1.27673,"nMoreExtreme":20154,"size":5,"leadingEdge":["LIG4","TCF7"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE","pval":0.09854,"padj":0.66685,"ES":0.92424,"NES":1.27665,"nMoreExtreme":6335,"size":27,"leadingEdge":["TBX21","HLA-F","JAK3","BCL6","PARP3","TNF","LILRB1","TGFB1","IL33"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS","pval":0.10915,"padj":0.69556,"ES":0.9186,"NES":1.27657,"nMoreExtreme":7050,"size":28,"leadingEdge":["XRN1","PARP3","SRC","STN1"]} {"pathway":"GO_RESPONSE_TO_ANTIBIOTIC","pval":0.02632,"padj":0.40796,"ES":0.7239,"NES":1.27573,"nMoreExtreme":2363,"size":248,"leadingEdge":["IL18BP","CIITA","LRRK2","HGF","STAT1","GRIN3A","JAK2","CCL7","XRN1","VCAM1","CYP1A1","ICAM1","KLF4","ZC3H12A","EDN1","POLB","NR4A3","TNFAIP3","IL6","TXN","SLC8A1","PLA2G4A","SMPD3","STAT3","SRC","TXNIP","GATA3","NFE2L2","PDGFB","BAK1"]} {"pathway":"GO_CHAPERONE_MEDIATED_AUTOPHAGY","pval":0.00906,"padj":0.24715,"ES":0.99303,"NES":1.27571,"nMoreExtreme":542,"size":16,"leadingEdge":["ATP13A2","LAMP2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_HEART_CONTRACTION","pval":0.0264,"padj":0.40796,"ES":0.97954,"NES":1.27571,"nMoreExtreme":1605,"size":18,"leadingEdge":["JAK2","SPTBN4","SRI","ZC3H12A","PIK3CG"]} {"pathway":"GO_INTERFERON_ALPHA_PRODUCTION","pval":0.10149,"padj":0.67304,"ES":0.92344,"NES":1.27555,"nMoreExtreme":6525,"size":27,"leadingEdge":["NMI","STAT1","RIPK2","TLR8","IRF7","IFIH1","TLR7","LILRA4","TLR3","DDX58","IRF5","TLR4"]} {"pathway":"GO_SEQUESTERING_OF_ACTIN_MONOMERS","pval":0.10669,"padj":0.68464,"ES":0.97511,"NES":1.27552,"nMoreExtreme":5798,"size":7,"leadingEdge":["SCIN","TMSB10","GSN"]} {"pathway":"GO_POSITIVE_REGULATION_OF_HYDROLASE_ACTIVITY","pval":0.0019,"padj":0.0971,"ES":0.70028,"NES":1.27535,"nMoreExtreme":186,"size":655,"leadingEdge":["ATP1B2","PSME2","AIM2","CD40","LRRK2","ITK","CCL13","PLEK","TNFSF10","PSME1","TAGAP","JAK2","AGT","RIPK2","CCL7","FAS","ICAM1","BCL2L11","ARAP2","CCL15","VPS9D1","RSU1","PML","CCL8","MEFV","RASGRF1","RAPGEF2","CASP4","USP6NL","PMAIP1","S100A10","CCL18","CCL5","LYN","TANK","PLSCR1","DENND1B","CASP10","ARHGAP25","RASGEF1B","FGF10","TNF","FLT1","RASGRP1","CCL1","PTPRC","PTAFR","CCL4","NR1H3","CASP5","F3","CCL2","STAT3","P2RY12","ARHGAP17","TBC1D2B","CDC42EP2","ROBO1","CCL19","AKIRIN2","PDGFRA","GM2A","LPAR1","CCL3","RGS1","CX3CL1","PRELID1","CFLAR","RGS9","CASP1","NKX3-1","PPARGC1B","SEMA4D","BBC3","PLCB1","ELMOD1","NAPA","SMAD3","LMF1"]} {"pathway":"GO_CELL_VOLUME_HOMEOSTASIS","pval":0.10188,"padj":0.67367,"ES":0.92328,"NES":1.27533,"nMoreExtreme":6550,"size":27,"leadingEdge":["P2RX7","SLC12A3","SLC12A7","KCNMA1","CLCN6"]} {"pathway":"GO_INTERLEUKIN_2_SECRETION","pval":0.00514,"padj":0.18481,"ES":0.99831,"NES":1.27515,"nMoreExtreme":286,"size":9,"leadingEdge":["GBP1","EZR"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MEMBRANE_DEPOLARIZATION","pval":0.00573,"padj":0.19643,"ES":0.99809,"NES":1.27486,"nMoreExtreme":319,"size":9,"leadingEdge":["P2RX7","DCN"]} {"pathway":"GO_REGULATION_OF_PHAGOCYTOSIS","pval":0.08345,"padj":0.64848,"ES":0.79757,"NES":1.27486,"nMoreExtreme":6265,"size":75,"leadingEdge":["IL15RA","C4A","C4B","IL15","C2","C3","CD300LF","STAP1","DYSF","IL2RG","TNF","CD47","CAMK1D","PTPRC","ATG3","CCL2","TGFB1","GAS6"]} {"pathway":"GO_RRNA_CATABOLIC_PROCESS","pval":0.01915,"padj":0.35444,"ES":0.98572,"NES":1.27476,"nMoreExtreme":1156,"size":17,"leadingEdge":["XRN1","EXOSC7"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_PRODUCTION","pval":0.11733,"padj":0.70191,"ES":0.8639,"NES":1.27471,"nMoreExtreme":8018,"size":41,"leadingEdge":["AIM2","P2RX7","NOD2","JAK2","RIPK2","TLR8","GSDMD","LILRA2","CCL19","CCL3","CASP1","SMAD3","LILRA5","TLR4","PANX2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MEMORY_T_CELL_DIFFERENTIATION","pval":0.38995,"padj":0.8943,"ES":0.92664,"NES":1.27467,"nMoreExtreme":20633,"size":5,"leadingEdge":["IL12RB1","IL12B"]} {"pathway":"GO_MAGNESIUM_ION_TRANSPORT","pval":0.01936,"padj":0.35444,"ES":0.98561,"NES":1.27461,"nMoreExtreme":1169,"size":17,"leadingEdge":["KCNJ2","NIPAL3"]} {"pathway":"GO_REGULATION_OF_RESPONSE_TO_STRESS","pval":0.00007,"padj":0.01095,"ES":0.69573,"NES":1.27413,"nMoreExtreme":6,"size":1232,"leadingEdge":["IRF1","TIFA","GBP5","IDO1","PSME2","AIM2","CD74","SOCS1","LRRK2","GCH1","IL12RB1","PSMB9","IL15","SERPING1","LAG3","NOD2","HLA-F","CEACAM1","PLEK","HGF","KREMEN1","NLRC5","PSME1","HLA-E","ACOD1","NMI","OPTN","STAT1","JAK2","SUCNR1","PSMB10","AGT","TRAFD1","RIPK2","TLR8","IL27","FAS","PSMB8","CAMK2D","RMI2","KLF4","SCARF1","BCL2L11","CLEC6A","MUC1","ZBP1","TGM2","ENPP4","TSPAN32","PML","C3","SLAMF6","APOBEC3G","CLEC10A","CD300LF","MEFV","TLR10","ZC3H12A","ABCB1","CTSS","CYLD","STAP1","IRF7","ICAM2","RSAD2","EDN1","IFIH1","SLAMF1","NCF1","DTX3L","NRK","PMAIP1","LILRA2","IL1RN","SBNO2","GADD45B","DDX60","HLA-G","SLAMF8","PTGER4","RELB","BCL6","CCL18","CCL5","LYN","IL12A","PYHIN1","DTNBP1","TNFAIP6","PARP14","TLR7","TICAM2","LTA","NR4A3","TANK","PARP3","PARP9","CTSL","SOD2","PLSCR1","IRF4","TNFAIP3","EDEM1","LILRA4","BIRC3","MYD88","APOBEC3F","IL6","TLR3","CLEC4D","CLEC4E","FGF10","TXN","GADD45G","SEMA7A","TNF","PSMA4","PSMA2","SERPINB9","CD226","CUL1","DUSP10","CD47","RASGRP1","PIK3AP1","CCL1","FGD2","CXCL12","PTPRC","DDX58","NR1H3","LILRB1","F3","SOCS3","PTPN2","DHX58","PAK1","MNDA","SRC","A2M","IL2RA","CCL19","CGAS","WDFY1","CDKN1A","PSMA5","GP1BA","PRDX1","PDGFRA","NAMPT","IKBKE","SLC7A2","HELB","PTPN1","NFKBIA","TREML4","RGMA","GRINA","MCL1","SH3RF1","OTUD4","PTGS2","CCL3","CX3CL1","USP18","GATA3","BIRC7","NKX3-1","NFE2L2","IL33","HERPUD1","ERAP1","PLCB1","IL1R2","PDGFB","SMAD3"]} {"pathway":"GO_LEUKOCYTE_DIFFERENTIATION","pval":0.00963,"padj":0.25147,"ES":0.70693,"NES":1.27387,"nMoreExtreme":915,"size":414,"leadingEdge":["IRF1","IL31RA","UBD","CD74","HLA-DOA","SOCS1","SNX10","IL12RB1","ITK","IL15","TBX21","CEACAM1","BATF2","CTLA4","TMEM176A","TMEM176B","RIPK2","BATF3","IL27","VCAM1","LILRB3","FLT3LG","CD80","B2M","SLAMF6","ZC3H12A","JAK3","CYLD","IRF7","RSAD2","BTN2A2","SBNO2","HLA-G","SLAMF8","PTGER4","RELB","BCL6","LYN","CSF1","IL7","CD83","IRF4","IL6","TLR3","CLEC4D","CLEC4E","LILRB4","EGR3","NOTCH2","TNF","DUSP10","CD86","GPR18","RASGRP1","FARP2","PTPRC","RHOH","LILRB1","TPD52","KLF6","STAT3","PTPN2","RUNX1","SRC","TGFB1","SEMA4A","OCSTAMP","IL2RA","CCL19","CCR6","C1QC","LIG4","SH3RF1","GAS6","CCL3","PRELID1","GATA3","MT1G","PPARGC1B"]} {"pathway":"GO_INTERLEUKIN_6_PRODUCTION","pval":0.06073,"padj":0.58891,"ES":0.76185,"NES":1.27381,"nMoreExtreme":4894,"size":117,"leadingEdge":["P2RX7","NOD2","HGF","BANK1","RIPK2","TLR8","ZC3H12A","IFIH1","SLAMF1","LILRA2","IL1RN","TLR7","TNFAIP3","MYD88","IL6","TLR3","TNF","CD47","PTAFR","DDX58","STAT3","AKIRIN2","GAS6","CX3CL1","IL33","FCER1G","LILRA5","TLR4","IL18RAP","EREG","TICAM1","SIGLEC16","TLR1","ORM1","LILRB2"]} {"pathway":"GO_DNA_CATABOLIC_PROCESS_EXONUCLEOLYTIC","pval":0.39371,"padj":0.89503,"ES":0.92602,"NES":1.27381,"nMoreExtreme":20832,"size":5,"leadingEdge":["ISG20","ERI1"]} {"pathway":"GO_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_CATABOLIC_PROCESS","pval":0.11694,"padj":0.70159,"ES":0.86013,"NES":1.27379,"nMoreExtreme":8018,"size":42,"leadingEdge":["DPYS","TYMP","APOBEC3D","ENPP4","APOBEC3A","APOBEC3G","APOBEC3F","ADA2","ENTPD2"]} {"pathway":"GO_INTERLEUKIN_1_BETA_PRODUCTION","pval":0.08921,"padj":0.65884,"ES":0.80499,"NES":1.27377,"nMoreExtreme":6602,"size":69,"leadingEdge":["GBP5","AIM2","P2RX7","NOD2","JAK2","SUCNR1","RIPK2","TLR8","GSDMD","PML","MEFV","ZC3H12A","CARD17","CARD16","LILRA2","TNFAIP3","MR1","CCL19","CCL3","CX3CL1","CASP1","SMAD3"]} {"pathway":"GO_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY_IN_RESPONSE_TO_VIRUS","pval":0.07716,"padj":0.63581,"ES":0.93896,"NES":1.27348,"nMoreExtreme":4886,"size":24,"leadingEdge":["IRF7","IFIH1","DDX60","BIRC3","DDX58","DHX58","TSPAN6"]} {"pathway":"GO_REGULATION_OF_ENDOPLASMIC_RETICULUM_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY","pval":0.1259,"padj":0.71867,"ES":0.91136,"NES":1.27326,"nMoreExtreme":8169,"size":29,"leadingEdge":["LRRK2","BCL2L11","PMAIP1","PTPN2","PTPN1","GRINA","HERPUD1"]} {"pathway":"GO_MITOCHONDRIAL_FISSION","pval":0.13632,"padj":0.73298,"ES":0.90197,"NES":1.27323,"nMoreExtreme":8923,"size":31,"leadingEdge":["LRRK2","STAT2","MX1","DDHD1","COX10"]} {"pathway":"GO_TRANS_SYNAPTIC_SIGNALING_BY_LIPID","pval":0.39704,"padj":0.89503,"ES":0.92551,"NES":1.27311,"nMoreExtreme":21008,"size":5,"leadingEdge":["PLCB1","DAGLA"]} {"pathway":"GO_SMOOTH_MUSCLE_CELL_APOPTOTIC_PROCESS","pval":0.04426,"padj":0.52747,"ES":0.96402,"NES":1.2727,"nMoreExtreme":2735,"size":20,"leadingEdge":["EDN1","IL12A","SOD2","IGF1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_WNT_SIGNALING_PATHWAY","pval":0.04864,"padj":0.5476,"ES":0.74329,"NES":1.27252,"nMoreExtreme":4099,"size":156,"leadingEdge":["PSME2","LRRK2","PSMB9","PSME1","DKK2","PSMB10","PSMB8","AMER1","TNFAIP3","FGF10","PSMA4","PSMA2","SRC","PSMA5"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS","pval":0.05655,"padj":0.57014,"ES":0.75315,"NES":1.27245,"nMoreExtreme":4643,"size":132,"leadingEdge":["LRRK2","NUB1","RNF19B","PYHIN1","AMER1","TNFAIP3","EDEM1","RNF144B","GCLC","CTSC","NFE2L2","IL33","HERPUD1","NUPR1","RNF19A","EDEM2","PRICKLE1"]} {"pathway":"GO_VITAMIN_CATABOLIC_PROCESS","pval":0.24034,"padj":0.82313,"ES":0.9514,"NES":1.27219,"nMoreExtreme":12898,"size":6,"leadingEdge":["CBR3","CYP27B1","CYP26B1"]} {"pathway":"GO_REGULATION_OF_CALCIDIOL_1_MONOOXYGENASE_ACTIVITY","pval":0.24034,"padj":0.82313,"ES":0.9514,"NES":1.27219,"nMoreExtreme":12898,"size":6,"leadingEdge":["TNF","CYP27B1","NFKB1"]} {"pathway":"GO_REGULATION_OF_HISTONE_DEACETYLASE_ACTIVITY","pval":0.05563,"padj":0.56688,"ES":0.98545,"NES":1.27193,"nMoreExtreme":3064,"size":8,"leadingEdge":["LRRK2","CAMK2D","KDM5A"]} {"pathway":"GO_TETRAPYRROLE_BIOSYNTHETIC_PROCESS","pval":0.1114,"padj":0.69864,"ES":0.92081,"NES":1.27191,"nMoreExtreme":7162,"size":27,"leadingEdge":["ALAS1","MMAA","SPTA1","COX10"]} {"pathway":"GO_VIRAL_GENOME_REPLICATION","pval":0.06425,"padj":0.59701,"ES":0.76358,"NES":1.27183,"nMoreExtreme":5144,"size":112,"leadingEdge":["ISG20","IFI27","IFITM2","APOBEC3D","IFITM1","CCL8","APOBEC3A","APOBEC3G","ZC3H12A","PARP10","RSAD2","IFITM3","CCL5","IFIT5","OAS3","PLSCR1","APOBEC3F","TNF","MX1","CCL2","CXCL8","ADAR","ISG15","GAS6","STOM","OASL"]} {"pathway":"GO_INTERLEUKIN_1_ALPHA_PRODUCTION","pval":0.4033,"padj":0.89503,"ES":0.92455,"NES":1.2718,"nMoreExtreme":21339,"size":5,"leadingEdge":["P2RX7","S100A13","CX3CL1","IL1R2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_1_MEDIATED_SIGNALING_PATHWAY","pval":0.4033,"padj":0.89503,"ES":0.92455,"NES":1.2718,"nMoreExtreme":21339,"size":5,"leadingEdge":["IL1RN","IL6","OTUD4","IL1R2"]} {"pathway":"GO_REGULATION_OF_LIPID_KINASE_ACTIVITY","pval":0.10439,"padj":0.67936,"ES":0.82846,"NES":1.27177,"nMoreExtreme":7430,"size":54,"leadingEdge":["SOCS1","NOD2","KLF4","CISH","LYN","FLT1","FPR2","SOCS3","P2RY12","SRC","TGFB1","CCL19","PDGFRA","PDGFB","AGAP2"]} {"pathway":"GO_REGULATION_OF_GAMMA_DELTA_T_CELL_DIFFERENTIATION","pval":0.24231,"padj":0.82387,"ES":0.95107,"NES":1.27174,"nMoreExtreme":13004,"size":6,"leadingEdge":["EGR3","PTPRC","NCKAP1L"]} {"pathway":"GO_REGULATION_OF_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY","pval":0.12247,"padj":0.71068,"ES":0.91506,"NES":1.27165,"nMoreExtreme":7910,"size":28,"leadingEdge":["PDE4B","SRI","DYSF","STAC3","GEM","S100A1","GPR35"]} {"pathway":"GO_CELLULAR_KETONE_METABOLIC_PROCESS","pval":0.04998,"padj":0.55243,"ES":0.74404,"NES":1.27164,"nMoreExtreme":4197,"size":153,"leadingEdge":["PSME2","PSMB9","PSME1","PSMB10","PSMB8","DHRS9","DGAT2","NR4A3","PSMA4","PSMA2","KMO","PSMA5","GPD2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_P38MAPK_CASCADE","pval":0.07165,"padj":0.62112,"ES":0.94362,"NES":1.27162,"nMoreExtreme":4507,"size":23,"leadingEdge":["ZC3H12A","NCF1","GADD45B","GADD45G","MAP3K4"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_EPINEPHRINE_STIMULUS","pval":0.01449,"padj":0.31281,"ES":0.99545,"NES":1.27149,"nMoreExtreme":809,"size":9,"leadingEdge":["PDE4B","KCNQ1"]} {"pathway":"GO_GLOMERULAR_MESANGIAL_CELL_DIFFERENTIATION","pval":0.40551,"padj":0.89503,"ES":0.92427,"NES":1.27141,"nMoreExtreme":21456,"size":5,"leadingEdge":["PDGFB","ACTA2"]} {"pathway":"GO_MESANGIAL_CELL_DEVELOPMENT","pval":0.40551,"padj":0.89503,"ES":0.92427,"NES":1.27141,"nMoreExtreme":21456,"size":5,"leadingEdge":["PDGFB","ACTA2"]} {"pathway":"GO_METANEPHRIC_GLOMERULAR_MESANGIUM_DEVELOPMENT","pval":0.40551,"padj":0.89503,"ES":0.92427,"NES":1.27141,"nMoreExtreme":21456,"size":5,"leadingEdge":["PDGFB","PDGFRB"]} {"pathway":"GO_GLYCOLYTIC_PROCESS_THROUGH_FRUCTOSE_6_PHOSPHATE","pval":0.05429,"padj":0.56056,"ES":0.95637,"NES":1.27138,"nMoreExtreme":3378,"size":21,"leadingEdge":["PFKP","PKM"]} {"pathway":"GO_NODAL_SIGNALING_PATHWAY","pval":0.40662,"padj":0.89503,"ES":0.92411,"NES":1.27118,"nMoreExtreme":21515,"size":5,"leadingEdge":["TGIF2","SMAD3","ACVR1B"]} {"pathway":"GO_POSITIVE_REGULATION_OF_EXTRACELLULAR_MATRIX_ASSEMBLY","pval":0.40662,"padj":0.89503,"ES":0.92411,"NES":1.27118,"nMoreExtreme":21515,"size":5,"leadingEdge":["TGFB1","SMAD3","RGCC"]} {"pathway":"GO_MELANOSOME_ASSEMBLY","pval":0.40723,"padj":0.89503,"ES":0.92399,"NES":1.27102,"nMoreExtreme":21547,"size":5,"leadingEdge":["RAB38","TRAPPC6A"]} {"pathway":"GO_REGULATION_OF_PHOSPHATIDYLCHOLINE_BIOSYNTHETIC_PROCESS","pval":0.40723,"padj":0.89503,"ES":0.92399,"NES":1.27102,"nMoreExtreme":21547,"size":5,"leadingEdge":["RAB38","FABP3"]} {"pathway":"GO_RESPONSE_TO_MUSCLE_ACTIVITY","pval":0.01514,"padj":0.31577,"ES":0.98938,"NES":1.27101,"nMoreExtreme":906,"size":16,"leadingEdge":["AGT","CAPN3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ANION_TRANSMEMBRANE_TRANSPORT","pval":0.24571,"padj":0.82387,"ES":0.95051,"NES":1.27099,"nMoreExtreme":13186,"size":6,"leadingEdge":["AGT","ABCB1","PTAFR","PSEN1"]} {"pathway":"GO_SERINE_TRANSPORT","pval":0.40868,"padj":0.89503,"ES":0.92377,"NES":1.27072,"nMoreExtreme":21624,"size":5,"leadingEdge":["NFKBIE","SLC38A7"]} {"pathway":"GO_ARTERY_SMOOTH_MUSCLE_CONTRACTION","pval":0.24733,"padj":0.82387,"ES":0.95022,"NES":1.27062,"nMoreExtreme":13273,"size":6,"leadingEdge":["CD38","AGT","EDN1","EDNRA"]} {"pathway":"GO_PEPTIDYL_ARGININE_MODIFICATION","pval":0.025,"padj":0.40148,"ES":0.9824,"NES":1.27047,"nMoreExtreme":1510,"size":17,"leadingEdge":["PADI2","ART3","NDUFAF7"]} {"pathway":"GO_SECRETION_OF_LYSOSOMAL_ENZYMES","pval":0.248,"padj":0.82387,"ES":0.95006,"NES":1.27039,"nMoreExtreme":13309,"size":6,"leadingEdge":["NR1H3","M6PR"]} {"pathway":"GO_REGULATION_OF_PANCREATIC_JUICE_SECRETION","pval":0.248,"padj":0.82387,"ES":0.95006,"NES":1.27039,"nMoreExtreme":13309,"size":6,"leadingEdge":["NR1H3","WNK1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_DENDRITIC_CELL_DIFFERENTIATION","pval":0.248,"padj":0.82387,"ES":0.95006,"NES":1.27039,"nMoreExtreme":13309,"size":6,"leadingEdge":["TMEM176A","TMEM176B","HLA-G","LILRB1","FCGR2B"]} {"pathway":"GO_RESPONSE_TO_MECHANICAL_STIMULUS","pval":0.04692,"padj":0.53858,"ES":0.73883,"NES":1.27038,"nMoreExtreme":3990,"size":166,"leadingEdge":["IRF1","CD40","P2RX7","CXCL10","STAT1","AGT","TLR8","FAS","KCNJ2","EDN1","PTGER4","TIFAB","TLR7","MYD88","TLR3","SLC8A1","HPN","CXCL12","CHI3L1","CASP5","GCLC","SRC","TGFB1","TXNIP","NFKBIA","PTGS2","ASNS","CASP1","PDZD7","BAK1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_GAMMA_DELTA_T_CELL_ACTIVATION","pval":0.24831,"padj":0.82387,"ES":0.95,"NES":1.27032,"nMoreExtreme":13326,"size":6,"leadingEdge":["NOD2","PTPRC","LILRB1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CD8_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION","pval":0.24831,"padj":0.82387,"ES":0.95,"NES":1.27032,"nMoreExtreme":13326,"size":6,"leadingEdge":["SOCS1","CD274","LILRB1","HFE"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_STEROL","pval":0.03332,"padj":0.46677,"ES":0.97538,"NES":1.27029,"nMoreExtreme":2026,"size":18,"leadingEdge":["GRAMD1B","RORA"]} {"pathway":"GO_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE","pval":0.00327,"padj":0.13423,"ES":0.69849,"NES":1.27023,"nMoreExtreme":319,"size":606,"leadingEdge":["HLA-DMB","CD40","IL12RB1","TBX21","HLA-F","CEACAM1","ADGRE5","SELL","PADI2","SUCNR1","FGL2","RIPK2","IL27","ICAM1","LILRB3","ENPP4","TNFSF18","CD80","GSDMD","B2M","C3","SLAMF6","S100A13","ZC3H12A","CTSS","JAK3","SLAMF1","IGF2R","MVP","LILRA2","SBNO2","DYSF","PTGER4","DYNLT1","RELB","BCL6","LYN","TNFAIP6","MMP25","TICAM2","NR4A3","PARP3","IRF4","ANXA3","CTSZ","IL6","CLEC4D","CLEC4E","NOTCH2","PSMA2","CD86","CD47","RASGRP1","RAB24","ITGAL","PTPRC","CHI3L1","PTAFR","LILRB1","FPR2","STAT3","NBN","MNDA","TGFB1","SEMA4A","CCL19","CCR6","PSMA5","ADA2","CTSC","GM2A","CREG1","HVCN1","LIG4","CCL3","ACPP","TCIM","SLC44A2","GATA3","IL33","DNAJC13","SERPINB1","CD53","GNS","CRISPLD2","STOM","NFAM1","FCER1G","HLX","FCGR3B","CXCL1","TLR4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_HOMOOLIGOMERIZATION","pval":0.06212,"padj":0.5938,"ES":0.98382,"NES":1.26983,"nMoreExtreme":3422,"size":8,"leadingEdge":["BCL2L11","BID"]} {"pathway":"GO_GLIAL_CELL_ACTIVATION","pval":0.11873,"padj":0.70349,"ES":0.85108,"NES":1.26981,"nMoreExtreme":8214,"size":44,"leadingEdge":["LRRK2","TLR8","STAP1","TLR7","IL6","TLR3","TNF","PTPRC","FPR2","NAMPT","CCL3","CX3CL1","IL33"]} {"pathway":"GO_FATTY_ACID_ELONGATION_SATURATED_FATTY_ACID","pval":0.25103,"padj":0.82605,"ES":0.94955,"NES":1.26972,"nMoreExtreme":13472,"size":6,"leadingEdge":["ELOVL7","ELOVL5"]} {"pathway":"GO_EXOCYTIC_INSERTION_OF_NEUROTRANSMITTER_RECEPTOR_TO_PLASMA_MEMBRANE","pval":0.41293,"padj":0.89503,"ES":0.92304,"NES":1.26971,"nMoreExtreme":21849,"size":5,"leadingEdge":["STX3","STX1B"]} {"pathway":"GO_EPITHELIAL_CILIUM_MOVEMENT_INVOLVED_IN_DETERMINATION_OF_LEFT_RIGHT_ASYMMETRY","pval":0.06278,"padj":0.59455,"ES":0.98371,"NES":1.26968,"nMoreExtreme":3458,"size":8,"leadingEdge":["DNAAF1","OFD1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_BY_COMPETITIVE_PROMOTER_BINDING","pval":0.06325,"padj":0.59455,"ES":0.98359,"NES":1.26954,"nMoreExtreme":3484,"size":8,"leadingEdge":["BHLHE41","MUC1","SMAD7"]} {"pathway":"GO_COPPER_ION_IMPORT","pval":0.4142,"padj":0.89503,"ES":0.92282,"NES":1.26942,"nMoreExtreme":21916,"size":5,"leadingEdge":["STEAP4","SLC31A1"]} {"pathway":"GO_PROTEIN_MANNOSYLATION","pval":0.06768,"padj":0.60666,"ES":0.94804,"NES":1.26925,"nMoreExtreme":4234,"size":22,"leadingEdge":["TMTC1","TMTC2","DPM1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_LIPASE_ACTIVITY","pval":0.41479,"padj":0.89503,"ES":0.9227,"NES":1.26925,"nMoreExtreme":21947,"size":5,"leadingEdge":["NR1H3","LMF1","ABHD5"]} {"pathway":"GO_PROTEIN_GLYCOSYLATION_IN_GOLGI","pval":0.41515,"padj":0.89503,"ES":0.92264,"NES":1.26917,"nMoreExtreme":21966,"size":5,"leadingEdge":["LMF1","FUT8"]} {"pathway":"GO_RESPONSE_TO_INTERLEUKIN_7","pval":0.11879,"padj":0.70349,"ES":0.91881,"NES":1.26916,"nMoreExtreme":7637,"size":27,"leadingEdge":["SOCS1","JAK3","CISH","IL7","IL2RG","STAT5A","STAT3","BTK"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INTERLEUKIN_8_BIOSYNTHETIC_PROCESS","pval":0.41609,"padj":0.89503,"ES":0.92253,"NES":1.26901,"nMoreExtreme":22016,"size":5,"leadingEdge":["TLR8","TLR7","TNF","TLR4"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_MECHANICAL_STIMULUS","pval":0.09297,"padj":0.66428,"ES":0.80024,"NES":1.26888,"nMoreExtreme":6903,"size":70,"leadingEdge":["IRF1","CD40","AGT","TLR8","FAS","KCNJ2","PTGER4","TLR7","MYD88","TLR3","CASP5","GCLC","TGFB1","PTGS2","CASP1","BAK1","TLR4"]} {"pathway":"GO_HISTONE_H2A_UBIQUITINATION","pval":0.09915,"padj":0.66778,"ES":0.92942,"NES":1.26832,"nMoreExtreme":6315,"size":25,"leadingEdge":["DTX3L","UBE2A","PCGF5","UBR2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PHOSPHATASE_ACTIVITY","pval":0.13169,"padj":0.72756,"ES":0.91249,"NES":1.26808,"nMoreExtreme":8506,"size":28,"leadingEdge":["PLEK","JAK2","PTPRC","PPARGC1B","SMAD3"]} {"pathway":"GO_DE_NOVO_NAD_BIOSYNTHETIC_PROCESS_FROM_TRYPTOPHAN","pval":0.25851,"padj":0.82758,"ES":0.94831,"NES":1.26806,"nMoreExtreme":13873,"size":6,"leadingEdge":["IDO1","IDO2","KYNU","KMO"]} {"pathway":"GO_REGULATION_OF_VIRAL_GENOME_REPLICATION","pval":0.08068,"padj":0.64196,"ES":0.7801,"NES":1.26806,"nMoreExtreme":6204,"size":88,"leadingEdge":["ISG20","IFI27","IFITM2","APOBEC3D","IFITM1","CCL8","APOBEC3A","APOBEC3G","ZC3H12A","PARP10","RSAD2","IFITM3","CCL5","IFIT5","OAS3","PLSCR1","APOBEC3F","TNF","MX1","CXCL8","ADAR","ISG15","STOM","OASL"]} {"pathway":"GO_PERISTALSIS","pval":0.25929,"padj":0.82758,"ES":0.94825,"NES":1.26798,"nMoreExtreme":13915,"size":6,"leadingEdge":["SSTR2","TIFAB","NEUROG1"]} {"pathway":"GO_REGULATION_BY_VIRUS_OF_VIRAL_PROTEIN_LEVELS_IN_HOST_CELL","pval":0.13597,"padj":0.73234,"ES":0.96932,"NES":1.26795,"nMoreExtreme":7390,"size":7,"leadingEdge":["STAT1","DYNLT1","HACD3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CILIUM","pval":0.42265,"padj":0.89612,"ES":0.92135,"NES":1.26739,"nMoreExtreme":22363,"size":5,"leadingEdge":["GAS8","CROCC"]} {"pathway":"GO_AUTOPHAGY_OF_PEROXISOME","pval":0.42405,"padj":0.89658,"ES":0.92118,"NES":1.26716,"nMoreExtreme":22437,"size":5,"leadingEdge":["ACBD5","RB1CC1"]} {"pathway":"GO_LIPID_LOCALIZATION","pval":0.02552,"padj":0.40216,"ES":0.71417,"NES":1.26706,"nMoreExtreme":2329,"size":283,"leadingEdge":["APOL4","APOL1","APOL3","P2RX7","APOL2","CEACAM1","APOL6","AGT","ANO4","ACSL1","OSBPL6","SOAT1","C3","ZC3H12A","ABCB1","P2RX4","GRAMD1B","EDN1","TTC39B","DGAT2","DYSF","XKR6","PLSCR4","PLSCR1","SLC27A3","SLC51A","IL6","TNF","PLA2G4A","NCOA1","XKR8","LIPG","NR1H3","PTPN2","IKBKE","GM2A","NFKBIA","GLTPD2","CES1","MFSD2A","XKR7","PRELID1","NKX3-1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_STRESS","pval":0.10265,"padj":0.67367,"ES":0.92835,"NES":1.26686,"nMoreExtreme":6538,"size":25,"leadingEdge":["ATF3","MUC1","NFE2L2","MBTPS2"]} {"pathway":"GO_INTERLEUKIN_6_SECRETION","pval":0.14167,"padj":0.73885,"ES":0.88783,"NES":1.26676,"nMoreExtreme":9364,"size":33,"leadingEdge":["BANK1","TLR8","ZC3H12A","IFIH1","LILRA2","TNF","DDX58","GAS6","LILRA5"]} {"pathway":"GO_REGULATION_OF_CHOLESTEROL_ESTERIFICATION","pval":0.07249,"padj":0.62163,"ES":0.98141,"NES":1.26672,"nMoreExtreme":3993,"size":8,"leadingEdge":["AGT","APOA1"]} {"pathway":"GO_REGULATION_OF_MDA_5_SIGNALING_PATHWAY","pval":0.26592,"padj":0.83608,"ES":0.94719,"NES":1.26656,"nMoreExtreme":14271,"size":6,"leadingEdge":["DDX60","DHX58","RIOK3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_RIG_I_SIGNALING_PATHWAY","pval":0.26592,"padj":0.83608,"ES":0.94719,"NES":1.26656,"nMoreExtreme":14271,"size":6,"leadingEdge":["DDX60","DHX58","PUM2"]} {"pathway":"GO_MRNA_CLEAVAGE","pval":0.06263,"padj":0.59455,"ES":0.95271,"NES":1.26652,"nMoreExtreme":3897,"size":21,"leadingEdge":["MOV10","ZNRD1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_EMBRYONIC_DEVELOPMENT","pval":0.14837,"padj":0.7508,"ES":0.90161,"NES":1.26632,"nMoreExtreme":9671,"size":30,"leadingEdge":["AMOT","B4GALT5","GATA3","PLCB1","WNT1","SIX1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_VESICLE_FUSION","pval":0.26732,"padj":0.83635,"ES":0.94697,"NES":1.26626,"nMoreExtreme":14346,"size":6,"leadingEdge":["PRRT2","TRIM9","CORO1A"]} {"pathway":"GO_OLFACTORY_BULB_INTERNEURON_DEVELOPMENT","pval":0.42836,"padj":0.89886,"ES":0.92051,"NES":1.26623,"nMoreExtreme":22665,"size":5,"leadingEdge":["ATF5","ROBO1","SLIT2"]} {"pathway":"GO_TANGENTIAL_MIGRATION_FROM_THE_SUBVENTRICULAR_ZONE_TO_THE_OLFACTORY_BULB","pval":0.42836,"padj":0.89886,"ES":0.92051,"NES":1.26623,"nMoreExtreme":22665,"size":5,"leadingEdge":["LRRK2","ROBO1","SLIT2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS","pval":0.14867,"padj":0.7508,"ES":0.90154,"NES":1.26622,"nMoreExtreme":9691,"size":30,"leadingEdge":["ICAM1","TNFAIP3","ANGPTL4","GAS6","CFLAR","GATA3","NFE2L2","KRIT1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MONOCYTE_CHEMOTAXIS","pval":0.42868,"padj":0.89886,"ES":0.92045,"NES":1.26616,"nMoreExtreme":22682,"size":5,"leadingEdge":["SLAMF8","SLIT2"]} {"pathway":"GO_RESPONSE_TO_CORTISOL","pval":0.42902,"padj":0.89886,"ES":0.9204,"NES":1.26608,"nMoreExtreme":22700,"size":5,"leadingEdge":["SLIT2","CAD"]} {"pathway":"GO_RESPONSE_TO_ANTICOAGULANT","pval":0.42902,"padj":0.89886,"ES":0.9204,"NES":1.26608,"nMoreExtreme":22700,"size":5,"leadingEdge":["SLIT2","AOC1"]} {"pathway":"GO_RESPONSE_TO_HEPARIN","pval":0.42902,"padj":0.89886,"ES":0.9204,"NES":1.26608,"nMoreExtreme":22700,"size":5,"leadingEdge":["SLIT2","AOC1"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_HEPARIN","pval":0.42902,"padj":0.89886,"ES":0.9204,"NES":1.26608,"nMoreExtreme":22700,"size":5,"leadingEdge":["SLIT2","AOC1"]} {"pathway":"GO_REGULATION_OF_MAST_CELL_CHEMOTAXIS","pval":0.14539,"padj":0.74662,"ES":0.96771,"NES":1.26585,"nMoreExtreme":7902,"size":7,"leadingEdge":["VEGFC","VEGFD"]} {"pathway":"GO_MITOCHONDRION_LOCALIZATION","pval":0.12959,"padj":0.72293,"ES":0.86365,"NES":1.26569,"nMoreExtreme":8801,"size":39,"leadingEdge":["LRRK2","HAP1"]} {"pathway":"GO_MITOCHONDRIAL_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT","pval":0.09496,"padj":0.6659,"ES":0.93319,"NES":1.26564,"nMoreExtreme":6013,"size":24,"leadingEdge":["PSEN2","PARL","MCUB"]} {"pathway":"GO_RESPONSE_TO_TOXIC_SUBSTANCE","pval":0.01477,"padj":0.31281,"ES":0.70433,"NES":1.26543,"nMoreExtreme":1394,"size":378,"leadingEdge":["IL18BP","LRRK2","GCH1","HGF","STAT1","GRIN3A","CCL7","XRN1","VCAM1","CYP1A1","ICAM1","KLF4","ZC3H12A","EDN1","NUCB1","GSTK1","MT2A","POLB","CCL5","LYN","EPHX1","NR4A3","SOD2","TNFAIP3","IL6","TXN","MT1M","TNF","SLC8A1","SCN9A","MT1E","SMPD3","CCL4","NR4A2","STAT3","SRC","KCNMA1","CDKN1A","TXNIP","PRDX1","MT1H","PTGS2","ASNS","CES1","CCL3","RGS9","GATA3","MT1G","NFE2L2","CLIC2","PDGFB","BAK1","NUPR1","SLC31A1","IL18RAP","KCNMB1","ASS1","SLC30A4","ZNF277","MET","ADORA2A"]} {"pathway":"GO_MYD88_DEPENDENT_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY","pval":0.14036,"padj":0.73744,"ES":0.88266,"NES":1.2654,"nMoreExtreme":9317,"size":34,"leadingEdge":["IRF1","TLR8","CD300LF","TLR10","IRF7","TLR7","MYD88","TLR4"]} {"pathway":"GO_REGULATION_OF_CD8_POSITIVE_ALPHA_BETA_T_CELL_DIFFERENTIATION","pval":0.27181,"padj":0.83739,"ES":0.94618,"NES":1.26521,"nMoreExtreme":14587,"size":6,"leadingEdge":["SOCS1","RUNX1","RUNX3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_LAMELLIPODIUM_MORPHOGENESIS","pval":0.27231,"padj":0.83739,"ES":0.94612,"NES":1.26513,"nMoreExtreme":14614,"size":6,"leadingEdge":["ENPP2","SRC","ARHGEF7"]} {"pathway":"GO_POSITIVE_REGULATION_OF_AMYLOID_BETA_FORMATION","pval":0.01038,"padj":0.25928,"ES":0.9964,"NES":1.26497,"nMoreExtreme":585,"size":10,"leadingEdge":["GSAP","PICALM"]} {"pathway":"GO_ACTIN_NUCLEATION","pval":0.12281,"padj":0.71181,"ES":0.84452,"NES":1.2644,"nMoreExtreme":8525,"size":45,"leadingEdge":["SCIN","ACTR3C","AP1AR","WAS"]} {"pathway":"GO_NECROTIC_CELL_DEATH","pval":0.12295,"padj":0.71181,"ES":0.84442,"NES":1.26426,"nMoreExtreme":8535,"size":45,"leadingEdge":["FAS","CYLD","TICAM2","BIRC3","TLR3","TNF","RBCK1","CFLAR","TLR4","TICAM1","MLKL"]} {"pathway":"GO_RIBOFLAVIN_METABOLIC_PROCESS","pval":0.4375,"padj":0.90126,"ES":0.91899,"NES":1.26415,"nMoreExtreme":23149,"size":5,"leadingEdge":["RFK","ACP5"]} {"pathway":"GO_RESPONSE_TO_ETHER","pval":0.08131,"padj":0.64456,"ES":0.97938,"NES":1.2641,"nMoreExtreme":4479,"size":8,"leadingEdge":["ZC3H12A","ABCB4"]} {"pathway":"GO_MITOCHONDRIAL_PROTEIN_PROCESSING","pval":0.00472,"padj":0.17418,"ES":0.99753,"NES":1.26404,"nMoreExtreme":274,"size":13,"leadingEdge":["LRRK2","MIPEP"]} {"pathway":"GO_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_REGENERATION","pval":0.43805,"padj":0.90126,"ES":0.91888,"NES":1.26399,"nMoreExtreme":23178,"size":5,"leadingEdge":["MYOZ1","CAPN3"]} {"pathway":"GO_MAST_CELL_CYTOKINE_PRODUCTION","pval":0.43852,"padj":0.90126,"ES":0.91882,"NES":1.26392,"nMoreExtreme":23203,"size":5,"leadingEdge":["BCL6","NR4A3","FCER1G"]} {"pathway":"GO_REGULATION_OF_MAST_CELL_CYTOKINE_PRODUCTION","pval":0.43852,"padj":0.90126,"ES":0.91882,"NES":1.26392,"nMoreExtreme":23203,"size":5,"leadingEdge":["BCL6","NR4A3","FCER1G"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TOLERANCE_INDUCTION","pval":0.15297,"padj":0.75292,"ES":0.96623,"NES":1.26391,"nMoreExtreme":8314,"size":7,"leadingEdge":["IDO1","CD274","HLA-G","LILRB2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ACTIN_NUCLEATION","pval":0.03452,"padj":0.47454,"ES":0.97729,"NES":1.26385,"nMoreExtreme":2085,"size":17,"leadingEdge":["SCIN","WAS"]} {"pathway":"GO_SEROTONIN_SECRETION","pval":0.43881,"padj":0.90126,"ES":0.91877,"NES":1.26384,"nMoreExtreme":23218,"size":5,"leadingEdge":["LILRB1","FCER1G","P2RX1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CYTOKINE_SECRETION","pval":0.07422,"padj":0.62748,"ES":0.76312,"NES":1.2635,"nMoreExtreme":5886,"size":105,"leadingEdge":["AIM2","P2RX7","CD274","LRRK2","NOD2","CLEC9A","RIPK2","TLR8","CLEC6A","GSDMD","IFIH1","LILRA2","PTGER4","TNFRSF14","CLEC4E","TNF","RASGRP1","CCL1","DDX58","SRC","CCL19","CCL3","GATA3","CASP1","IL33","IL1A","LILRA5","TLR4","CD244","PANX2"]} {"pathway":"GO_GUANOSINE_CONTAINING_COMPOUND_METABOLIC_PROCESS","pval":0.1125,"padj":0.69864,"ES":0.92576,"NES":1.26333,"nMoreExtreme":7166,"size":25,"leadingEdge":["LRRK2","GIMAP7","GTPBP1","RHOQ","AK4"]} {"pathway":"GO_REGULATION_OF_LYSOSOMAL_LUMEN_PH","pval":0.00529,"padj":0.18752,"ES":0.99753,"NES":1.26319,"nMoreExtreme":304,"size":12,"leadingEdge":["LRRK2","GRN"]} {"pathway":"GO_POSITIVE_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS_BY_HOST","pval":0.1026,"padj":0.67367,"ES":0.93129,"NES":1.26306,"nMoreExtreme":6497,"size":24,"leadingEdge":["AIM2","IL12RB1","STAT1","IL27","APOBEC3G","ZC3H12A","DTX3L","PARP9","APOBEC3F","DDX58","LILRB1","CGAS"]} {"pathway":"GO_VERY_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS","pval":0.08624,"padj":0.65271,"ES":0.97831,"NES":1.26272,"nMoreExtreme":4751,"size":8,"leadingEdge":["ACOT4","ACAA1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_6_MEDIATED_SIGNALING_PATHWAY","pval":0.10448,"padj":0.67936,"ES":0.94737,"NES":1.26272,"nMoreExtreme":5227,"size":1,"leadingEdge":["PTPN2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CYTOKINE_SECRETION_INVOLVED_IN_IMMUNE_RESPONSE","pval":0.15787,"padj":0.76265,"ES":0.96528,"NES":1.26266,"nMoreExtreme":8580,"size":7,"leadingEdge":["TNFRSF14","MAPK3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_DEUBIQUITINATION","pval":0.15787,"padj":0.76265,"ES":0.96528,"NES":1.26266,"nMoreExtreme":8580,"size":7,"leadingEdge":["ZC3H12A","TANK","SART3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_VASCULOGENESIS","pval":0.08642,"padj":0.65271,"ES":0.97826,"NES":1.26265,"nMoreExtreme":4761,"size":8,"leadingEdge":["CEACAM1","RAPGEF2","RAP1A"]} {"pathway":"GO_IMMUNE_RESPONSE_INHIBITING_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY","pval":0.44432,"padj":0.90355,"ES":0.91787,"NES":1.26261,"nMoreExtreme":23510,"size":5,"leadingEdge":["HLA-G","LYN","LILRB1","CLEC12B","LILRB2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_SIGNALING_PATHWAY","pval":0.28422,"padj":0.84677,"ES":0.94416,"NES":1.2625,"nMoreExtreme":15253,"size":6,"leadingEdge":["ROBO1","SMOC2"]} {"pathway":"GO_PROTOPORPHYRINOGEN_IX_BIOSYNTHETIC_PROCESS","pval":0.08806,"padj":0.65627,"ES":0.97792,"NES":1.26221,"nMoreExtreme":4851,"size":8,"leadingEdge":["ALAS1","CPOX"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CGMP_MEDIATED_SIGNALING","pval":0.28563,"padj":0.84868,"ES":0.94393,"NES":1.2622,"nMoreExtreme":15329,"size":6,"leadingEdge":["NPR1","GUCA1A","CGAS","RUNDC3A"]} {"pathway":"GO_REGULATION_OF_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS","pval":0.05103,"padj":0.55514,"ES":0.73251,"NES":1.26214,"nMoreExtreme":4354,"size":171,"leadingEdge":["PSME2","LRRK2","LAMP3","PSME1","NUB1","RNF19B","EDEM1","RNF144B","GCLC","NFE2L2","IL33","HERPUD1","NUPR1","RNF19A"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_MURAMYL_DIPEPTIDE","pval":0.04141,"padj":0.51963,"ES":0.98809,"NES":1.26209,"nMoreExtreme":2313,"size":9,"leadingEdge":["NOD2","RIPK2","VIM"]} {"pathway":"GO_POSITIVE_REGULATION_OF_DEPHOSPHORYLATION","pval":0.12014,"padj":0.70555,"ES":0.83284,"NES":1.26189,"nMoreExtreme":8429,"size":49,"leadingEdge":["PLEK","JAK2","PTPRC","TGFB1","PPARGC1B","SMAD3","PPP1R16B","LILRB2"]} {"pathway":"GO_REGULATION_OF_PROTEIN_POLYUBIQUITINATION","pval":0.06358,"padj":0.59606,"ES":0.95566,"NES":1.26166,"nMoreExtreme":3929,"size":20,"leadingEdge":["NOD2","NMI","PARP10","DYSF","UBE2D1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MYELINATION","pval":0.01903,"padj":0.35444,"ES":0.99365,"NES":1.26147,"nMoreExtreme":1073,"size":10,"leadingEdge":["HGF","RNF10"]} {"pathway":"GO_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION","pval":0.04236,"padj":0.52235,"ES":0.72338,"NES":1.26145,"nMoreExtreme":3707,"size":205,"leadingEdge":["IL31RA","CD40","CD74","SOCS1","IL15","HGF","BANK1","JAK2","AGT","RIPK2","ICAM1","TNFSF18","CD80","STAP1","ENPP2","NCF1","MVP","STAP2","CCL5","LYN","IL12A","PARP14","TNFRSF14","PARP9","IL7","IL6","FGF10","TNF","PTPRC","SOCS3","STAT3","PTPN2","SRC","TGFB1","PTPN1","GAS6","SRCIN1","SEMA4D","SPINK1","PDGFB"]} {"pathway":"GO_MYELOID_LEUKOCYTE_CYTOKINE_PRODUCTION","pval":0.15027,"padj":0.75097,"ES":0.90762,"NES":1.26131,"nMoreExtreme":9706,"size":28,"leadingEdge":["CD74","HLA-G","BCL6","NR4A3","SEMA7A","DDX58","LILRB1","TGFB1","GAS6","FCER1G","TLR4","TICAM1"]} {"pathway":"GO_REGULATION_OF_PROTEIN_GLYCOSYLATION","pval":0.01007,"padj":0.25928,"ES":0.99601,"NES":1.26126,"nMoreExtreme":574,"size":11,"leadingEdge":["IL15","POMT2"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_VIRUS","pval":0.12498,"padj":0.71645,"ES":0.83962,"NES":1.26122,"nMoreExtreme":8698,"size":46,"leadingEdge":["BCL2L11","ZC3H12A","IRF7","IFIH1","DDX60","IL12A","BIRC3","DDX58","DHX58","CCL19","IKBKE","IFI6"]} {"pathway":"GO_REGULATION_OF_ENTRY_OF_BACTERIUM_INTO_HOST_CELL","pval":0.29063,"padj":0.85125,"ES":0.94315,"NES":1.26115,"nMoreExtreme":15597,"size":6,"leadingEdge":["CXCL8","FUCA2"]} {"pathway":"GO_CELLULAR_PROTEIN_CATABOLIC_PROCESS","pval":0.00268,"padj":0.11935,"ES":0.69202,"NES":1.26104,"nMoreExtreme":263,"size":684,"leadingEdge":["UBD","PSME2","LRRK2","PSMB9","FBXO6","LAMP3","TBX21","ATP13A2","PSME1","PSMB10","NUB1","IFI27","UBE2L6","PSMB8","PML","RNF19B","CTSS","CYLD","CTSO","DTX3L","PMAIP1","CHMP4C","PYHIN1","CTSL","AMER1","TNFAIP3","EDEM1","RNF144B","CTSZ","PSMA4","PSMA2","SPOPL","RBCK1","CUL1","TRIM72","UBE2A","TRIM71","TRIM9","GCLC","PSMA5","CTSC","UBE2Z","ISG15","USP18","TRIM25","ERLIN1","NFE2L2","IL33","HERPUD1"]} {"pathway":"GO_REGULATION_OF_WNT_SIGNALING_PATHWAY","pval":0.02489,"padj":0.40148,"ES":0.70848,"NES":1.26098,"nMoreExtreme":2291,"size":303,"leadingEdge":["PSME2","LRRK2","PSMB9","KREMEN1","PSME1","DKK2","PSMB10","PSMB8","CMAHP","CYLD","TRABD2A","PTPRU","AMER1","TNFAIP3","FGF10","PSMA4","PSMA2","TCF7L1","RUNX1","SRC","PSMA5"]} {"pathway":"GO_POSITIVE_REGULATION_OF_VASCULAR_ASSOCIATED_SMOOTH_MUSCLE_CELL_APOPTOTIC_PROCESS","pval":0.16473,"padj":0.76986,"ES":0.96393,"NES":1.2609,"nMoreExtreme":8953,"size":7,"leadingEdge":["SOD2","STK4"]} {"pathway":"GO_APOPTOTIC_PROCESS_INVOLVED_IN_DEVELOPMENT","pval":0.15151,"padj":0.75292,"ES":0.90728,"NES":1.26083,"nMoreExtreme":9786,"size":28,"leadingEdge":["BCL2L11","XKR6","XKR8","FOXC1","XKR7","SLIT2","BAK1","HNF1B"]} {"pathway":"GO_GALACTOSE_CATABOLIC_PROCESS_VIA_UDP_GALACTOSE","pval":0.45304,"padj":0.90517,"ES":0.91652,"NES":1.26075,"nMoreExtreme":23971,"size":5,"leadingEdge":["GALM","GALK1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_AUTOPHAGOSOME_MATURATION","pval":0.29288,"padj":0.85286,"ES":0.94281,"NES":1.2607,"nMoreExtreme":15718,"size":6,"leadingEdge":["CALCOCO2","UVRAG","CLEC16A"]} {"pathway":"GO_RESPONSE_TO_EPINEPHRINE","pval":0.0114,"padj":0.27533,"ES":0.99545,"NES":1.26055,"nMoreExtreme":650,"size":11,"leadingEdge":["PDE4B","KCNQ1"]} {"pathway":"GO_REGULATION_OF_CELLULAR_KETONE_METABOLIC_PROCESS","pval":0.07432,"padj":0.62748,"ES":0.75771,"NES":1.26006,"nMoreExtreme":5935,"size":110,"leadingEdge":["PSME2","PSMB9","PSME1","PSMB10","PSMB8","DGAT2","NR4A3","PSMA4","PSMA2","PSMA5"]} {"pathway":"GO_RESPONSE_TO_EXTRACELLULAR_STIMULUS","pval":0.01453,"padj":0.31281,"ES":0.69976,"NES":1.26001,"nMoreExtreme":1379,"size":406,"leadingEdge":["CD40","P2RX7","LRRK2","IL15","CXCL10","NOD2","SELL","ATF3","SSTR2","STAT1","PIM1","C2","FAS","ACSL1","VCAM1","CYP1A1","ICAM1","GSDMD","ZC3H12A","P2RX4","RALB","FAM107A","PMAIP1","LYN","GLUL","CADPS2","LTA","KYNU","SLC8A1","VGF","NCOA1","ASCL1","CYP27B1","PTPRC","SLC25A25","LIPG","NR4A2","SIK1B","P2RY12","NUAK2","GCLC","SRC","TGFB1","CDKN1A","UCP2","NAMPT","RRAGC","P2RY2","PTGS2","GAS6","ASNS","TRIM25","RRAGD","NFE2L2"]} {"pathway":"GO_REGULATION_OF_PROTEIN_COMPLEX_STABILITY","pval":0.04855,"padj":0.5476,"ES":0.98635,"NES":1.25986,"nMoreExtreme":2712,"size":9,"leadingEdge":["TAPBP","HSPA8"]} {"pathway":"GO_RNA_SURVEILLANCE","pval":0.02484,"padj":0.40148,"ES":0.98572,"NES":1.2594,"nMoreExtreme":1475,"size":15,"leadingEdge":["XRN1","EXOSC7"]} {"pathway":"GO_PHOSPHATIDYLCHOLINE_CATABOLIC_PROCESS","pval":0.1713,"padj":0.77295,"ES":0.96272,"NES":1.25932,"nMoreExtreme":9310,"size":7,"leadingEdge":["ENPP2","SCARB1"]} {"pathway":"GO_REGULATION_OF_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY","pval":0.01855,"padj":0.35375,"ES":0.70192,"NES":1.25928,"nMoreExtreme":1745,"size":365,"leadingEdge":["AIM2","CD40","NOD2","RHEBL1","NLRC5","ACOD1","JAK2","AGT","PIM1","RIPK2","ICAM1","KLF4","TNFSF18","TRIM22","SRI","ZC3H12A","PARP10","CYLD","CARD16","EDN1","TRIM31","TNFAIP3","ANXA3","MYD88","IL6","TLR3","NFKB2","TNF","RBCK1","CAMK1D","DDX58","STAT3","TGFB1","TRIM21","NFKBIA","PKHD1","GAS6","CX3CL1","TRIM25","CFLAR","NKX3-1","PPARGC1B","SMAD3","NFKBIE","TRAF1","SIK1","NFAM1","ARID5B","FLOT1","TLR4","IL18RAP"]} {"pathway":"GO_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL","pval":0.04362,"padj":0.52235,"ES":0.72195,"NES":1.25927,"nMoreExtreme":3819,"size":206,"leadingEdge":["LRRK2","NOD2","NMI","RIPK2","ZC3H12A","PARP10","DTX3L","FAM107A","DYSF","TANK","AMER1","TNFAIP3","BIRC3","SPOPL","GCLC","TRIM21","ADGRB1","ISG15","OTUD4","HERPUD1"]} {"pathway":"GO_REGULATION_OF_PEPTIDE_SECRETION","pval":0.01934,"padj":0.35444,"ES":0.70226,"NES":1.25922,"nMoreExtreme":1817,"size":360,"leadingEdge":["AIM2","CD40","GBP1","CD74","P2RX7","SOCS1","CD274","LRRK2","CD38","NOD2","CLEC9A","ATP13A2","HLA-E","BANK1","HCAR2","JAK2","RIPK2","TLR8","SIDT2","CLEC6A","GSDMD","PML","SRI","TLR10","ZC3H12A","CARD17","CARD16","RSAD2","BTN2A2","VEGFC","IFIH1","LILRA2","PTGER4","CCL5","LYN","GLUL","TNFRSF14","TNFAIP3","IL6","CLEC4E","TNF","RASGRP1","CCL1","DDX58","NR1H3","LILRB1","SRC","TGFB1","CCL19","UCP2","RHBDF2","GAS6","CCL3","CX3CL1","GATA3","CASP1","SRCIN1","IL33","NADK","IL1R2"]} {"pathway":"GO_REGULATION_OF_PROTEIN_TYROSINE_PHOSPHATASE_ACTIVITY","pval":0.45995,"padj":0.90517,"ES":0.9154,"NES":1.2592,"nMoreExtreme":24337,"size":5,"leadingEdge":["PTPRC","GNAI2"]} {"pathway":"GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_CELL_DEATH","pval":0.11245,"padj":0.69864,"ES":0.81471,"NES":1.25919,"nMoreExtreme":8067,"size":57,"leadingEdge":["LRRK2","HGF","NR4A3","SOD2","TXN","MCL1","NFE2L2","TLR4","MET","WNT1"]} {"pathway":"GO_REGULATION_OF_CELL_ADHESION","pval":0.00566,"padj":0.19529,"ES":0.69327,"NES":1.25919,"nMoreExtreme":550,"size":573,"leadingEdge":["IRF1","HLA-DPA1","IDO1","HLA-DMB","GBP1","CD74","SOCS1","CD274","IL12RB1","PDCD1LG2","IL15","LAG3","HLA-DPB1","TBX21","NOD2","CEACAM1","HLA-E","CHRD","CTLA4","JAK2","RIPK2","ONECUT2","TNFSF13B","VCAM1","ICAM1","MDGA1","KLF4","MUC1","TGM2","RSU1","TNFSF18","CD80","PDCD1","PML","ZC3H12A","JAK3","CYLD","BTN2A2","MIR503","FAM107A","IL1RN","S100A10","DYSF","HLA-G","BCL6","CCL5","LYN","IL12A","CSF1","NR4A3","TNFRSF14","IL7","PTPRU","PRKX","CD83","RND1","IL6","LILRB4","EGR3","TNF","EBI3","DUSP10","CD86","CD47","RASGRP1","CXCL12","PTPRC","PTAFR","LILRB1","CCL2","P2RY12","PTPN2","PAK1","PODXL","RUNX1","SRC","TGFB1","ICOS","CCDC88B","IL2RA","CCL19","CXCL8"]} {"pathway":"GO_REGULATION_OF_MESENCHYMAL_STEM_CELL_DIFFERENTIATION","pval":0.30086,"padj":0.85813,"ES":0.94146,"NES":1.2589,"nMoreExtreme":16146,"size":6,"leadingEdge":["PDGFRA","REST"]} {"pathway":"GO_CHEMOKINE_C_C_MOTIF_LIGAND_5_PRODUCTION","pval":0.05127,"padj":0.55673,"ES":0.98556,"NES":1.25886,"nMoreExtreme":2864,"size":9,"leadingEdge":["MCOLN2","ARG2"]} {"pathway":"GO_VESICLE_TARGETING","pval":0.08906,"padj":0.6584,"ES":0.77513,"NES":1.25884,"nMoreExtreme":6843,"size":87,"leadingEdge":["CTSZ","CTSC","AP1AR","NAPA","TRAPPC6A"]} {"pathway":"GO_MIRNA_METABOLIC_PROCESS","pval":0.07833,"padj":0.63581,"ES":0.94692,"NES":1.25882,"nMoreExtreme":4874,"size":21,"leadingEdge":["TRIM71","RC3H2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS","pval":0.0264,"padj":0.40796,"ES":0.99146,"NES":1.25869,"nMoreExtreme":1489,"size":10,"leadingEdge":["ATF3","MBTPS2"]} {"pathway":"GO_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION","pval":0.0967,"padj":0.66591,"ES":0.78626,"NES":1.25867,"nMoreExtreme":7274,"size":76,"leadingEdge":["PSME2","PSMB9","PSME1","PSMB10","PSMB8","PSMA4","PSMA2","RUNX1","PSMA5","FOXC1","GATA3","NFE2L2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION_DOPAMINERGIC","pval":0.46371,"padj":0.90527,"ES":0.91472,"NES":1.25827,"nMoreExtreme":24536,"size":5,"leadingEdge":["FLOT1","DRD4"]} {"pathway":"GO_PLASMA_MEMBRANE_RAFT_ORGANIZATION","pval":0.46371,"padj":0.90527,"ES":0.91472,"NES":1.25827,"nMoreExtreme":24536,"size":5,"leadingEdge":["FLOT1","ABCA7"]} {"pathway":"GO_SUPEROXIDE_ANION_GENERATION","pval":0.10269,"padj":0.67367,"ES":0.9337,"NES":1.25825,"nMoreExtreme":6460,"size":23,"leadingEdge":["AGT","EDN1","NCF1","FPR2","TGFB1","NCF2","TYROBP"]} {"pathway":"GO_BRANCHING_MORPHOGENESIS_OF_A_NERVE","pval":0.05341,"padj":0.56014,"ES":0.98508,"NES":1.25825,"nMoreExtreme":2984,"size":9,"leadingEdge":["LRRK2","RERE"]} {"pathway":"GO_POLY_N_ACETYLLACTOSAMINE_BIOSYNTHETIC_PROCESS","pval":0.17595,"padj":0.77529,"ES":0.96185,"NES":1.25818,"nMoreExtreme":9563,"size":7,"leadingEdge":["B4GALT5","B3GNT7"]} {"pathway":"GO_POSITIVE_REGULATION_OF_FIBROBLAST_GROWTH_FACTOR_PRODUCTION","pval":0.46528,"padj":0.90625,"ES":0.9145,"NES":1.25797,"nMoreExtreme":24619,"size":5,"leadingEdge":["PTGS2","HEG1","CCM2L"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MEMBRANE_PERMEABILITY","pval":0.46566,"padj":0.9065,"ES":0.91444,"NES":1.25789,"nMoreExtreme":24639,"size":5,"leadingEdge":["HEG1","RASIP1"]} {"pathway":"GO_REGULATION_OF_MEMBRANE_REPOLARIZATION_DURING_ACTION_POTENTIAL","pval":0.177,"padj":0.77529,"ES":0.96163,"NES":1.25788,"nMoreExtreme":9620,"size":7,"leadingEdge":["RNF207","DLG1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS","pval":0.09878,"padj":0.66699,"ES":0.78792,"NES":1.25784,"nMoreExtreme":7404,"size":74,"leadingEdge":["LAMP3","ATP13A2","PML","WNT1","PANO1"]} {"pathway":"GO_FLOOR_PLATE_DEVELOPMENT","pval":0.52698,"padj":0.92669,"ES":0.88324,"NES":1.25777,"nMoreExtreme":27426,"size":4,"leadingEdge":["CHRD","COBL"]} {"pathway":"GO_LYSOSOMAL_PROTEIN_CATABOLIC_PROCESS","pval":0.01809,"padj":0.35354,"ES":0.99303,"NES":1.25749,"nMoreExtreme":1032,"size":11,"leadingEdge":["ATP13A2","LAMP2"]} {"pathway":"GO_CHROMATIN_DISASSEMBLY","pval":0.04504,"padj":0.53247,"ES":0.97236,"NES":1.25748,"nMoreExtreme":2721,"size":17,"leadingEdge":["PADI2","SMARCD3"]} {"pathway":"GO_DNA_CYTOSINE_DEAMINATION","pval":0.1788,"padj":0.77529,"ES":0.96129,"NES":1.25744,"nMoreExtreme":9718,"size":7,"leadingEdge":["APOBEC3D","APOBEC3A","APOBEC3G","APOBEC3F"]} {"pathway":"GO_REGULATION_OF_RUFFLE_ASSEMBLY","pval":0.12965,"padj":0.72293,"ES":0.92144,"NES":1.25743,"nMoreExtreme":8258,"size":25,"leadingEdge":["ICAM1","STAP1","P2RY12","COBL"]} {"pathway":"GO_N_ACETYLNEURAMINATE_CATABOLIC_PROCESS","pval":0.30792,"padj":0.86308,"ES":0.94034,"NES":1.2574,"nMoreExtreme":16525,"size":6,"leadingEdge":["NAGK","RENBP"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_8_PRODUCTION","pval":0.02824,"padj":0.42048,"ES":0.98404,"NES":1.25725,"nMoreExtreme":1677,"size":15,"leadingEdge":["KLF4","BCL3"]} {"pathway":"GO_REGULATION_OF_T_HELPER_CELL_DIFFERENTIATION","pval":0.15755,"padj":0.76265,"ES":0.89063,"NES":1.25722,"nMoreExtreme":10313,"size":31,"leadingEdge":["IL12RB1","TBX21","RIPK2","IL27","CD80","ZC3H12A","JAK3","BCL6","IRF4","CD86","CCL19"]} {"pathway":"GO_MITOCHONDRIAL_CALCIUM_ION_HOMEOSTASIS","pval":0.09348,"padj":0.66429,"ES":0.93905,"NES":1.2572,"nMoreExtreme":5848,"size":22,"leadingEdge":["TGM2","C19orf12","MCUB"]} {"pathway":"GO_REGULATION_OF_CELLULAR_RESPONSE_TO_MACROPHAGE_COLONY_STIMULATING_FACTOR_STIMULUS","pval":0.46935,"padj":0.9079,"ES":0.91388,"NES":1.25712,"nMoreExtreme":24834,"size":5,"leadingEdge":["STAP1","CSF1","PTPN2","TLR4"]} {"pathway":"GO_INTESTINAL_EPITHELIAL_STRUCTURE_MAINTENANCE","pval":0.47016,"padj":0.9079,"ES":0.91371,"NES":1.25688,"nMoreExtreme":24877,"size":5,"leadingEdge":["TLR4","SOX9"]} {"pathway":"GO_ALDOSTERONE_SECRETION","pval":0.52711,"padj":0.92669,"ES":0.88261,"NES":1.25688,"nMoreExtreme":27433,"size":4,"leadingEdge":["AGT","AGTR1"]} {"pathway":"GO_SECRETION","pval":0.00007,"padj":0.01095,"ES":0.68618,"NES":1.25684,"nMoreExtreme":6,"size":1296,"leadingEdge":["GBP5","AIM2","CD40","GBP1","CD74","P2RX7","SOCS1","CD274","LRRK2","SNX10","CD38","SERPING1","NOD2","HLA-F","CEACAM1","ADGRE5","BTN3A2","PLEK","TNFAIP2","CLEC9A","HGF","SELL","STX11","ATP13A2","BTN3A1","HLA-E","BANK1","PADI2","GRIN3A","HCAR2","JAK2","SUCNR1","FGL2","AGT","ERC2","RIPK2","TLR8","TNFSF13B","EXOC3L4","MCOLN2","SIDT2","CLEC6A","LILRB3","ENPP4","GSDMD","PRRT2","PML","SRI","B2M","CCL8","C3","S100A13","TLR10","ZC3H12A","CTSS","LGALS3BP","P2RX4","CARD17","SCIN","MCTP2","CARD16","NPR1","SCG3","RSAD2","RALB","BTN2A2","EDN1","VEGFC","IFIH1","IGF2R","MVP","LILRA2","IL1RN","COMP","EXOC3L1","DYSF","NAAA","PTGER4","DYNLT1","CCL5","LYN","OAS2","TIFAB","DTNBP1","GLUL","TNFAIP6","MMP25","SYNGR3","TICAM2","CADPS2","NR4A3","TNFRSF14","TNFAIP3","ANXA3","SLC51A","CTSZ","IL6","CLEC4D","CLEC4E","FGF10","RSC1A1","TNF","STAT5A","PSMA2","VGF","PLA2G4A","TRIM72","CD47","RASGRP1","SMPD3","CCL1","RAB24","ITGAL","NCOA1","CXCL12","LCP2","PTPRC","CHI3L1","PTAFR","DDX58","NR1H3","LILRB1","FPR2","TPD52","MAFA","KMO","CACNA1I","TUBA4A","P2RY12","PAK1","TRIM9","MNDA","SRC","TGFB1","ARHGAP17","A2M","SYT5","CCL19","PSMA5","UCP2","ADA2","CTSC","GM2A","RHBDF2","CREG1","HVCN1","P2RY2","ACTN2","GAS6","CCL3","CX3CL1","ACPP","SLC44A2","GATA3","CASP1","NKX3-1","SRCIN1","IL33","DNAJC13","SERPINB1","CD53","GLS","NADK","IL1R2","ENDOD1","PDGFB","GNS","NAPA","STX3","SYT17","LMF1","CRISPLD2"]} {"pathway":"GO_SPHINGOID_METABOLIC_PROCESS","pval":0.47054,"padj":0.9079,"ES":0.91366,"NES":1.25681,"nMoreExtreme":24897,"size":5,"leadingEdge":["KDSR","SGPP1"]} {"pathway":"GO_BASIC_AMINO_ACID_TRANSMEMBRANE_TRANSPORT","pval":0.31176,"padj":0.86489,"ES":0.93978,"NES":1.25664,"nMoreExtreme":16731,"size":6,"leadingEdge":["AGT","SLC7A2"]} {"pathway":"GO_REGULATION_OF_CILIUM_BEAT_FREQUENCY","pval":0.05848,"padj":0.58091,"ES":0.98371,"NES":1.25649,"nMoreExtreme":3267,"size":9,"leadingEdge":["DNAAF1","CFAP20"]} {"pathway":"GO_COPPER_ION_TRANSMEMBRANE_TRANSPORT","pval":0.31328,"padj":0.86489,"ES":0.93961,"NES":1.25642,"nMoreExtreme":16813,"size":6,"leadingEdge":["SLC31A2","SLC31A1"]} {"pathway":"GO_REGULATION_OF_CORE_PROMOTER_BINDING","pval":0.4728,"padj":0.90882,"ES":0.91332,"NES":1.25634,"nMoreExtreme":25017,"size":5,"leadingEdge":["KLF4","FOXC1","GTF2B"]} {"pathway":"GO_RESPONSE_TO_OSMOTIC_STRESS","pval":0.10556,"padj":0.68214,"ES":0.79507,"NES":1.25619,"nMoreExtreme":7799,"size":68,"leadingEdge":["ABCB1","DYSF","RELB","TLR3","TNF","KMO","KCNMA1","PTGS2","RCSD1","AQP9","BAD"]} {"pathway":"GO_TYPE_B_PANCREATIC_CELL_APOPTOTIC_PROCESS","pval":0.18408,"padj":0.77988,"ES":0.96033,"NES":1.25619,"nMoreExtreme":10005,"size":7,"leadingEdge":["IL6","WFS1"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_GOLGI_APPARATUS","pval":0.13365,"padj":0.72971,"ES":0.92051,"NES":1.25616,"nMoreExtreme":8513,"size":25,"leadingEdge":["GBP5","OPTN","GCC2"]} {"pathway":"GO_TERPENOID_BIOSYNTHETIC_PROCESS","pval":0.31649,"padj":0.86626,"ES":0.93912,"NES":1.25577,"nMoreExtreme":16985,"size":6,"leadingEdge":["CYP1A1","DHRS9","ALDH1A2"]} {"pathway":"GO_PARKIN_MEDIATED_STIMULATION_OF_MITOPHAGY_IN_RESPONSE_TO_MITOCHONDRIAL_DEPOLARIZATION","pval":0.31716,"padj":0.86626,"ES":0.93904,"NES":1.25566,"nMoreExtreme":17021,"size":6,"leadingEdge":["OPTN","HDAC6"]} {"pathway":"GO_HISTONE_MRNA_METABOLIC_PROCESS","pval":0.13591,"padj":0.73234,"ES":0.91996,"NES":1.25542,"nMoreExtreme":8657,"size":25,"leadingEdge":["XRN1","UPF1"]} {"pathway":"GO_LONG_TERM_SYNAPTIC_DEPRESSION","pval":0.09811,"padj":0.66591,"ES":0.93768,"NES":1.25537,"nMoreExtreme":6138,"size":22,"leadingEdge":["CD38","ARC","LILRB2"]} {"pathway":"GO_REGULATION_OF_SARCOMERE_ORGANIZATION","pval":0.47978,"padj":0.91553,"ES":0.91223,"NES":1.25484,"nMoreExtreme":25386,"size":5,"leadingEdge":["EDN1","PROX1"]} {"pathway":"GO_RESPONSE_TO_MYCOTOXIN","pval":0.4814,"padj":0.91676,"ES":0.91197,"NES":1.25449,"nMoreExtreme":25472,"size":5,"leadingEdge":["PDGFB","BAK1","ASS1","ACTB"]} {"pathway":"GO_XENOPHAGY","pval":0.03729,"padj":0.49711,"ES":0.98814,"NES":1.25448,"nMoreExtreme":2104,"size":10,"leadingEdge":["CALCOCO2","OPTN","RIPK2","ATG16L1"]} {"pathway":"GO_MACROPHAGE_ACTIVATION","pval":0.1004,"padj":0.67128,"ES":0.78364,"NES":1.25448,"nMoreExtreme":7553,"size":76,"leadingEdge":["IL31RA","CD74","LRRK2","SUCNR1","TLR8","ZC3H12A","STAP1","SBNO2","DYSF","TLR7","IL6","TLR3","TNF","PTPRC","NR1H3","FPR2","NAMPT","SLC7A2","CCL3","CX3CL1","IL33"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_OSMOTIC_STRESS","pval":0.15267,"padj":0.75292,"ES":0.87504,"NES":1.25447,"nMoreExtreme":10134,"size":34,"leadingEdge":["DYSF","RELB","PTGS2","RCSD1","BAD"]} {"pathway":"GO_CORTICOSTEROID_RECEPTOR_SIGNALING_PATHWAY","pval":0.02131,"padj":0.36805,"ES":0.98994,"NES":1.25443,"nMoreExtreme":1240,"size":13,"leadingEdge":["JAK2","CRY1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION","pval":0.1149,"padj":0.70006,"ES":0.93077,"NES":1.2543,"nMoreExtreme":7228,"size":23,"leadingEdge":["CD274","TBX21","ZC3H12A","JAK3","BCL6","RUNX1","HLX"]} {"pathway":"GO_BASEMENT_MEMBRANE_ORGANIZATION","pval":0.06923,"padj":0.61454,"ES":0.95654,"NES":1.25429,"nMoreExtreme":4251,"size":19,"leadingEdge":["CTSS","HPN","PHLDB1"]} {"pathway":"GO_REGULATION_OF_RELAXATION_OF_MUSCLE","pval":0.19231,"padj":0.79001,"ES":0.95877,"NES":1.25414,"nMoreExtreme":10452,"size":7,"leadingEdge":["PDE4B","CAMK2D","SRI","TIFAB","NEUROG1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELL_PROLIFERATION_INVOLVED_IN_HEART_MORPHOGENESIS","pval":0.48348,"padj":0.91689,"ES":0.91166,"NES":1.25406,"nMoreExtreme":25582,"size":5,"leadingEdge":["PIM1","SOX9"]} {"pathway":"GO_REGULATION_OF_CALCIUM_ION_IMPORT","pval":0.12877,"padj":0.72213,"ES":0.92453,"NES":1.2539,"nMoreExtreme":8154,"size":24,"leadingEdge":["DYSF","CXCL12","PSEN2","CCL2","CCL3","SPINK1","PDGFB","FYN"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PROTEIN_POLYUBIQUITINATION","pval":0.11887,"padj":0.70349,"ES":0.97129,"NES":1.25365,"nMoreExtreme":6549,"size":8,"leadingEdge":["PARP10","DYSF","UBR5"]} {"pathway":"GO_HOMOSERINE_METABOLIC_PROCESS","pval":0.48524,"padj":0.91689,"ES":0.91135,"NES":1.25364,"nMoreExtreme":25675,"size":5,"leadingEdge":["CBSL","MTHFD1"]} {"pathway":"GO_SHORT_CHAIN_FATTY_ACID_METABOLIC_PROCESS","pval":0.52761,"padj":0.92669,"ES":0.88029,"NES":1.25357,"nMoreExtreme":27459,"size":4,"leadingEdge":["ACOD1","ACOT4","ALDH5A1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL","pval":0.07528,"padj":0.63068,"ES":0.7474,"NES":1.25331,"nMoreExtreme":6096,"size":121,"leadingEdge":["LRRK2","NOD2","NMI","RIPK2","ZC3H12A","FAM107A","TANK","AMER1","BIRC3"]} {"pathway":"GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_IB","pval":0.12071,"padj":0.7062,"ES":0.97095,"NES":1.25322,"nMoreExtreme":6650,"size":8,"leadingEdge":["TAP2","HLA-F","HLA-B","HLA-E","HLA-A","HLA-C","B2M","HLA-G"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PEPTIDE_SECRETION","pval":0.04731,"padj":0.54093,"ES":0.71829,"NES":1.25321,"nMoreExtreme":4145,"size":207,"leadingEdge":["AIM2","P2RX7","CD274","LRRK2","CD38","NOD2","CLEC9A","ATP13A2","HLA-E","HCAR2","JAK2","RIPK2","TLR8","CLEC6A","GSDMD","SRI","VEGFC","IFIH1","LILRA2","PTGER4","GLUL","TNFRSF14","IL6","CLEC4E","TNF","RASGRP1","CCL1","DDX58","SRC","TGFB1","CCL19","CCL3","GATA3","CASP1","IL33","NADK","ILDR1","IL1A"]} {"pathway":"GO_NEUROMUSCULAR_PROCESS_CONTROLLING_POSTURE","pval":0.06871,"padj":0.61251,"ES":0.98112,"NES":1.25319,"nMoreExtreme":3839,"size":9,"leadingEdge":["GCH1","PRRT2","CNTNAP1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_DEFENSE_RESPONSE_TO_BACTERIUM","pval":0.48694,"padj":0.91689,"ES":0.91102,"NES":1.25317,"nMoreExtreme":25765,"size":5,"leadingEdge":["SIGLEC11","SIRT2"]} {"pathway":"GO_REGULATION_OF_AMINO_ACID_IMPORT_ACROSS_PLASMA_MEMBRANE","pval":0.19681,"padj":0.791,"ES":0.95801,"NES":1.25316,"nMoreExtreme":10697,"size":7,"leadingEdge":["AGT","PSEN1"]} {"pathway":"GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_EXOGENOUS_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_I_TAP_INDEPENDENT","pval":0.12101,"padj":0.7062,"ES":0.9709,"NES":1.25315,"nMoreExtreme":6667,"size":8,"leadingEdge":["HLA-F","HLA-B","HLA-E","HLA-A","HLA-C","B2M","HLA-G"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_CHOLESTEROL","pval":0.04335,"padj":0.52235,"ES":0.97538,"NES":1.25303,"nMoreExtreme":2596,"size":16,"leadingEdge":["GRAMD1B","LRP6"]} {"pathway":"GO_PEPTIDE_METABOLIC_PROCESS","pval":0.09116,"padj":0.66096,"ES":0.76714,"NES":1.25302,"nMoreExtreme":7065,"size":92,"leadingEdge":["GSAP","TAPBP","GSTK1","CTNS","GGT5","DNPEP","PSEN2","HAP1"]} {"pathway":"GO_OLIGODENDROCYTE_PROGENITOR_PROLIFERATION","pval":0.48849,"padj":0.91689,"ES":0.91083,"NES":1.25291,"nMoreExtreme":25847,"size":5,"leadingEdge":["LYN","SIRT2"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_PEPTIDOGLYCAN","pval":0.48849,"padj":0.91689,"ES":0.91082,"NES":1.2529,"nMoreExtreme":25847,"size":5,"leadingEdge":["NOD2","RIPK2"]} {"pathway":"GO_MULTICELLULAR_ORGANISMAL_MOVEMENT","pval":0.14043,"padj":0.73744,"ES":0.84901,"NES":1.25274,"nMoreExtreme":9597,"size":41,"leadingEdge":["KCNJ2","COMP","MYH7","STAC3","ASCL1","RCSD1"]} {"pathway":"GO_RECEPTOR_BIOSYNTHETIC_PROCESS","pval":0.08284,"padj":0.64752,"ES":0.94869,"NES":1.25247,"nMoreExtreme":5120,"size":20,"leadingEdge":["EDN1","TNF","NR1H3","ACHE"]} {"pathway":"GO_PYRIMIDINE_DIMER_REPAIR","pval":0.12385,"padj":0.71286,"ES":0.97028,"NES":1.25235,"nMoreExtreme":6823,"size":8,"leadingEdge":["POLB","ERCC1"]} {"pathway":"GO_RNA_CATABOLIC_PROCESS","pval":0.02072,"padj":0.36483,"ES":0.69763,"NES":1.25233,"nMoreExtreme":1952,"size":371,"leadingEdge":["PSME2","PSMB9","PSME1","ISG20","PSMB10","PSMB8","XRN1","SIDT2","SAMD4A","ZC3H12A","GTPBP1","OAS2","MYD88","PSMA4","PSMA2","HELZ2","MOV10","TRIM71","PSMA5","LIN28A","ZFP36","PRR5L"]} {"pathway":"GO_REELIN_MEDIATED_SIGNALING_PATHWAY","pval":0.20018,"padj":0.79183,"ES":0.9573,"NES":1.25222,"nMoreExtreme":10880,"size":7,"leadingEdge":["STAT5A","CRKL"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_NF_KAPPAB_TRANSCRIPTION_FACTOR_ACTIVITY","pval":0.10737,"padj":0.68779,"ES":0.78837,"NES":1.25219,"nMoreExtreme":7990,"size":71,"leadingEdge":["AIM2","NLRC5","ACOD1","KLF4","ZC3H12A","PARP10","CYLD","TNFAIP3","RBCK1","TRIM21","NFKBIA","PKHD1"]} {"pathway":"GO_ENDOSOME_TRANSPORT_VIA_MULTIVESICULAR_BODY_SORTING_PATHWAY","pval":0.12128,"padj":0.70719,"ES":0.92916,"NES":1.25212,"nMoreExtreme":7630,"size":23,"leadingEdge":["SORT1","RILP"]} {"pathway":"GO_CERAMIDE_1_PHOSPHATE_TRANSPORT","pval":0.33464,"padj":0.87575,"ES":0.93635,"NES":1.25206,"nMoreExtreme":17959,"size":6,"leadingEdge":["GLTPD2","PLEKHA8"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING","pval":0.15731,"padj":0.76265,"ES":0.91187,"NES":1.25194,"nMoreExtreme":10064,"size":26,"leadingEdge":["XRN1","SRC","STN1","HNRNPC"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ACTION_POTENTIAL","pval":0.49331,"padj":0.91907,"ES":0.90995,"NES":1.25171,"nMoreExtreme":26102,"size":5,"leadingEdge":["GPR35","SUMO1"]} {"pathway":"GO_REGULATION_OF_CYTOLYSIS","pval":0.33689,"padj":0.87637,"ES":0.936,"NES":1.2516,"nMoreExtreme":18080,"size":6,"leadingEdge":["P2RX7","LILRB1","TGFB1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INTERFERON_GAMMA_SECRETION","pval":0.49456,"padj":0.91907,"ES":0.90978,"NES":1.25147,"nMoreExtreme":26168,"size":5,"leadingEdge":["RASGRP1","CD244","ABL1"]} {"pathway":"GO_IMMUNE_SYSTEM_DEVELOPMENT","pval":0.00189,"padj":0.0971,"ES":0.68523,"NES":1.2513,"nMoreExtreme":186,"size":802,"leadingEdge":["IRF1","IL31RA","IDO1","UBD","PSME2","CD40","CD74","HLA-DOA","SOCS1","CD274","SNX10","IL12RB1","ITK","PSMB9","IL15","TBX21","CEACAM1","PLEK","PSME1","HLA-E","ACOD1","BATF2","STAT1","CTLA4","JAK2","PSMB10","TMEM176A","TMEM176B","RIPK2","BATF3","IL27","PSMB8","VCAM1","KLF4","BCL2L11","LILRB3","FLT3LG","CD80","PDCD1","PML","B2M","SLAMF6","ZC3H12A","JAK3","CYLD","SCIN","IRF7","RSAD2","BTN2A2","SBNO2","HLA-G","SLAMF8","POLB","PTGER4","RELB","BCL6","LYN","CSF1","LTA","NR4A3","PARP3","IL7","PRKX","CD83","IRF4","TNFAIP3","IL6","TLR3","CLEC4D","CLEC4E","LILRB4","FGF10","LTB","EGR3","NFKB2","NOTCH2","TNF","FST","PSMA4","PSMA2","DUSP10","CD86","GPR18","RASGRP1","SMPD3","MOV10","FARP2","PTPRC","RHOH","LILRB1","TPD52","KLF6","STAT3","NBN","PTPN2","MYO1E","RUNX1","SRC","TGFB1","SEMA4A","ICOS","OCSTAMP","IL2RA","CCL19","CCR6","C1QC","PSMA5","GP1BA","PDGFRA","CDKN1C","NFKBIA","LIG4","ISG15","SH3RF1","GAS6","CCL3","FOXC1","PRELID1","TCIM","GATA3","MT1G","NFE2L2","PPARGC1B"]} {"pathway":"GO_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS","pval":0.03874,"padj":0.50613,"ES":0.7092,"NES":1.25116,"nMoreExtreme":3490,"size":253,"leadingEdge":["LRRK2","FBXO6","ATF3","BCL2L11","PML","RASGRF1","CASP4","PMAIP1","CHAC1","EDEM1","CCL2","PTPN2","CXCL8","PTPN1","GRINA","CREBRF","ASNS","TRIM25","ERLIN1","NFE2L2","HERPUD1","BBC3","BAK1","FLOT1"]} {"pathway":"GO_MAINTENANCE_OF_SYNAPSE_STRUCTURE","pval":0.02818,"padj":0.42041,"ES":0.98735,"NES":1.25114,"nMoreExtreme":1640,"size":13,"leadingEdge":["ERC2","DLG3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_APOPTOTIC_PROCESS","pval":0.04677,"padj":0.53858,"ES":0.98545,"NES":1.25106,"nMoreExtreme":2639,"size":10,"leadingEdge":["AGT","CAMK2D","CAMK2A"]} {"pathway":"GO_REGULATION_OF_DEACETYLASE_ACTIVITY","pval":0.04677,"padj":0.53858,"ES":0.98545,"NES":1.25106,"nMoreExtreme":2639,"size":10,"leadingEdge":["LRRK2","CAMK2D","KDM5A"]} {"pathway":"GO_FRUCTOSE_1_6_BISPHOSPHATE_METABOLIC_PROCESS","pval":0.20531,"padj":0.79637,"ES":0.9564,"NES":1.25105,"nMoreExtreme":11159,"size":7,"leadingEdge":["PFKP","TIGAR"]} {"pathway":"GO_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT_VIA_HIGH_VOLTAGE_GATED_CALCIUM_CHANNEL","pval":0.04693,"padj":0.53858,"ES":0.98539,"NES":1.25099,"nMoreExtreme":2648,"size":10,"leadingEdge":["CAMK2D","CACNB1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_HYPERSENSITIVITY","pval":0.3401,"padj":0.87818,"ES":0.93549,"NES":1.25092,"nMoreExtreme":18252,"size":6,"leadingEdge":["HLA-E","C3","FCER1G","BTK"]} {"pathway":"GO_ACTIVATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS","pval":0.10338,"padj":0.67471,"ES":0.78033,"NES":1.25073,"nMoreExtreme":7789,"size":77,"leadingEdge":["TNFSF10","JAK2","FAS","PML","CASP4","PMAIP1","CASP10","TNF","CASP5","F3","ROBO1","CASP1","NKX3-1","BBC3","SMAD3","BAK1","NGF"]} {"pathway":"GO_COENZYME_CATABOLIC_PROCESS","pval":0.07684,"padj":0.63581,"ES":0.97915,"NES":1.25068,"nMoreExtreme":4293,"size":9,"leadingEdge":["CBR3","ACAT1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_BROWN_FAT_CELL_DIFFERENTIATION","pval":0.34129,"padj":0.87818,"ES":0.93528,"NES":1.25063,"nMoreExtreme":18316,"size":6,"leadingEdge":["PTGS2","MAPK14"]} {"pathway":"GO_REGULATION_OF_UNSATURATED_FATTY_ACID_BIOSYNTHETIC_PROCESS","pval":0.34129,"padj":0.87818,"ES":0.93528,"NES":1.25063,"nMoreExtreme":18316,"size":6,"leadingEdge":["PTGS2","PIBF1"]} {"pathway":"GO_CYTOSKELETAL_ANCHORING_AT_PLASMA_MEMBRANE","pval":0.04881,"padj":0.54786,"ES":0.985,"NES":1.25049,"nMoreExtreme":2754,"size":10,"leadingEdge":["SPTBN4","EPB41L3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_BLOOD_VESSEL_DIAMETER","pval":0.13949,"padj":0.73582,"ES":0.84134,"NES":1.25048,"nMoreExtreme":9604,"size":43,"leadingEdge":["GCH1","AGT","SOD2","PTAFR","KCNMA1","GUCY1A1","SCPEP1","KCNMB1","ADORA2A"]} {"pathway":"GO_RESPONSE_TO_VITAMIN","pval":0.10605,"padj":0.68361,"ES":0.78317,"NES":1.25026,"nMoreExtreme":7949,"size":74,"leadingEdge":["CD40","IL15","CXCL10","PIM1","CYP1A1","KYNU","ASCL1","CYP27B1","TGFB1","PTGS2","GAS6","TRIM25","MTHFR","ALDH1A2","PTN"]} {"pathway":"GO_PORE_COMPLEX_ASSEMBLY","pval":0.04113,"padj":0.51837,"ES":0.97851,"NES":1.25018,"nMoreExtreme":2443,"size":15,"leadingEdge":["P2RX7","GSDMD","BAD"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT","pval":0.06875,"padj":0.61251,"ES":0.9598,"NES":1.25001,"nMoreExtreme":4182,"size":18,"leadingEdge":["TXN","TPR"]} {"pathway":"GO_POSITIVE_REGULATION_OF_KERATINOCYTE_PROLIFERATION","pval":0.345,"padj":0.88254,"ES":0.93472,"NES":1.24988,"nMoreExtreme":18515,"size":6,"leadingEdge":["FGF10","HAS2","CDH3"]} {"pathway":"GO_EMBRYONIC_DIGESTIVE_TRACT_DEVELOPMENT","pval":0.17285,"padj":0.7737,"ES":0.90483,"NES":1.24984,"nMoreExtreme":11113,"size":27,"leadingEdge":["FGF10","TNF","CXCL8","PDGFRA","HLX","ALDH1A2","HNF1B"]} {"pathway":"GO_ATRIOVENTRICULAR_CANAL_DEVELOPMENT","pval":0.34543,"padj":0.88254,"ES":0.93466,"NES":1.24981,"nMoreExtreme":18538,"size":6,"leadingEdge":["HAS2","TBX2"]} {"pathway":"GO_REGULATION_OF_PROTEIN_OLIGOMERIZATION","pval":0.16035,"padj":0.76421,"ES":0.87592,"NES":1.24976,"nMoreExtreme":10599,"size":33,"leadingEdge":["AIM2","BCL2L11","PMAIP1","TRABD2A","SRC"]} {"pathway":"GO_INFLAMMATORY_CELL_APOPTOTIC_PROCESS","pval":0.0791,"padj":0.63606,"ES":0.95306,"NES":1.24972,"nMoreExtreme":4857,"size":19,"leadingEdge":["NOD2","HCAR2","IRF7","CTSL","IL6","CCR5"]} {"pathway":"GO_ALDITOL_CATABOLIC_PROCESS","pval":0.34645,"padj":0.88258,"ES":0.93449,"NES":1.24958,"nMoreExtreme":18593,"size":6,"leadingEdge":["GK","GPD2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ASPARTIC_TYPE_PEPTIDASE_ACTIVITY","pval":0.13526,"padj":0.73185,"ES":0.96809,"NES":1.24952,"nMoreExtreme":7452,"size":8,"leadingEdge":["LYN","GRN"]} {"pathway":"GO_REGULATION_OF_BILE_ACID_BIOSYNTHETIC_PROCESS","pval":0.50359,"padj":0.91988,"ES":0.90832,"NES":1.24947,"nMoreExtreme":26646,"size":5,"leadingEdge":["PROX1","SIRT1"]} {"pathway":"GO_RESPONSE_TO_FUNGICIDE","pval":0.05159,"padj":0.55686,"ES":0.9841,"NES":1.24935,"nMoreExtreme":2911,"size":10,"leadingEdge":["XRN1","KLF4","KDM1A"]} {"pathway":"GO_CHOLESTEROL_CATABOLIC_PROCESS","pval":0.05219,"padj":0.55686,"ES":0.98393,"NES":1.24913,"nMoreExtreme":2945,"size":10,"leadingEdge":["HSD3B7","SCARF1","CYP46A1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NEURON_PROJECTION_REGENERATION","pval":0.05219,"padj":0.55686,"ES":0.98393,"NES":1.24913,"nMoreExtreme":2945,"size":10,"leadingEdge":["HGF","SCARF1","GRN"]} {"pathway":"GO_REGULATION_OF_CELLULAR_CATABOLIC_PROCESS","pval":0.00323,"padj":0.13339,"ES":0.68471,"NES":1.24899,"nMoreExtreme":318,"size":736,"leadingEdge":["PSME2","P2RX7","CALCOCO2","LRRK2","PSMB9","LAMP3","HGF","ATP13A2","PSME1","OPTN","PSMB10","NUB1","RIPK2","PSMB8","XRN1","BCL2L11","SAMD4A","TRIM22","PML","RNF19B","MEFV","ZC3H12A","DRAM1","RALB","GTPBP1","DTX3L","PYHIN1","RUFY4","TMEM150A","AMER1","TNFAIP3","EDEM1","RNF144B","MYD88","TNF","RMC1","PSMA4","PSMA2","MOV10","STAT3","TRIM71","GCLC","UVRAG","PSMA5","ATP6V1A","NAMPT","TRIM21","CTSC","RRAGC","PTPN1","MCL1","PLEKHF1","DEPP1","RRAGD","NFE2L2","IL33","HERPUD1","DAPK2","ZFP36","PRR5L","NUPR1","RNF19A","ESRRB","C9orf72"]} {"pathway":"GO_REGULATION_OF_CILIUM_MOVEMENT","pval":0.05297,"padj":0.55951,"ES":0.9837,"NES":1.24885,"nMoreExtreme":2989,"size":10,"leadingEdge":["DNAAF1","CFAP20"]} {"pathway":"GO_PLASMA_MEMBRANE_REPAIR","pval":0.21652,"padj":0.80167,"ES":0.95455,"NES":1.24862,"nMoreExtreme":11768,"size":7,"leadingEdge":["MYOF","DYSF","TRIM72","SYT7"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_T_CELL_MIGRATION","pval":0.52823,"padj":0.92669,"ES":0.87679,"NES":1.24858,"nMoreExtreme":27491,"size":4,"leadingEdge":["RIPOR2","CD200"]} {"pathway":"GO_NUCLEAR_BODY_ORGANIZATION","pval":0.03938,"padj":0.50897,"ES":0.981,"NES":1.24842,"nMoreExtreme":2317,"size":14,"leadingEdge":["PML","HIPK2"]} {"pathway":"GO_MITOPHAGY","pval":0.10373,"padj":0.67569,"ES":0.93903,"NES":1.24834,"nMoreExtreme":6455,"size":21,"leadingEdge":["OPTN","CLEC16A"]} {"pathway":"GO_ACTIN_FILAMENT_SEVERING","pval":0.08475,"padj":0.65213,"ES":0.9773,"NES":1.24831,"nMoreExtreme":4735,"size":9,"leadingEdge":["SCIN","MYH9"]} {"pathway":"GO_L_ASPARTATE_TRANSMEMBRANE_TRANSPORT","pval":0.21834,"padj":0.80167,"ES":0.95427,"NES":1.24826,"nMoreExtreme":11867,"size":7,"leadingEdge":["SLC25A22","SLC25A13"]} {"pathway":"GO_HISTONE_MRNA_CATABOLIC_PROCESS","pval":0.03608,"padj":0.48681,"ES":0.98573,"NES":1.24825,"nMoreExtreme":2080,"size":12,"leadingEdge":["XRN1","UPF1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_DENDRITIC_CELL_APOPTOTIC_PROCESS","pval":0.35357,"padj":0.888,"ES":0.93348,"NES":1.24823,"nMoreExtreme":18975,"size":6,"leadingEdge":["CXCL12","LILRB1","CCL19","GAS6"]} {"pathway":"GO_B_CELL_CHEMOTAXIS","pval":0.3539,"padj":0.88821,"ES":0.93343,"NES":1.24816,"nMoreExtreme":18993,"size":6,"leadingEdge":["HSD3B7","CH25H","GAS6"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_CALCIUM_ION_CONCENTRATION","pval":0.05508,"padj":0.56469,"ES":0.98314,"NES":1.24813,"nMoreExtreme":3108,"size":10,"leadingEdge":["TGM2","MCUR1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MAST_CELL_DEGRANULATION","pval":0.50956,"padj":0.92379,"ES":0.90731,"NES":1.24807,"nMoreExtreme":26962,"size":5,"leadingEdge":["CD84","HMOX1"]} {"pathway":"GO_CRANIAL_NERVE_FORMATION","pval":0.51022,"padj":0.92413,"ES":0.90722,"NES":1.24795,"nMoreExtreme":26997,"size":5,"leadingEdge":["TIFAB","NEUROG1"]} {"pathway":"GO_CHEMOKINE_PRODUCTION","pval":0.11024,"padj":0.69745,"ES":0.78421,"NES":1.24785,"nMoreExtreme":8226,"size":72,"leadingEdge":["CD74","RIPK2","MCOLN2","KLF4","MEFV","TLR7","IL7","IL6","TLR3","TNF","IL33","TLR4"]} {"pathway":"GO_REGULATION_OF_MUSCLE_CONTRACTION","pval":0.08217,"padj":0.64602,"ES":0.74631,"NES":1.24784,"nMoreExtreme":6622,"size":117,"leadingEdge":["PDE4B","SSTR2","KCNJ2","CAMK2D","SRI","ZC3H12A","P2RX4","EDN1","ANK2","MYH7","RNF207","SLC8A1","PTAFR","KCNMA1","GUCY1A1","PTGS2","CLIC2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY","pval":0.07492,"padj":0.63068,"ES":0.73735,"NES":1.24739,"nMoreExtreme":6165,"size":134,"leadingEdge":["AIM2","NLRC5","ACOD1","PIM1","KLF4","SRI","ZC3H12A","PARP10","CYLD","TNFAIP3","RBCK1","TRIM21","NFKBIA","PKHD1","GAS6","NFKBIE","SIK1"]} {"pathway":"GO_CHOLESTEROL_EFFLUX","pval":0.17176,"padj":0.77295,"ES":0.90849,"NES":1.2473,"nMoreExtreme":10989,"size":26,"leadingEdge":["SOAT1","TTC39B","NR1H3","NFKBIA","NPC1"]} {"pathway":"GO_VIRAL_LIFE_CYCLE","pval":0.03437,"padj":0.47454,"ES":0.70226,"NES":1.24728,"nMoreExtreme":3146,"size":290,"leadingEdge":["CD74","LAMP3","ISG20","IFI27","IFITM2","ICAM1","APOBEC3D","IFITM1","CD80","PML","CCL8","APOBEC3A","APOBEC3G","ZC3H12A","PARP10","RSAD2","USP6NL","SLAMF1","TRIM31","IFITM3","CHMP4C","DYNLT1","CCL5","IFIT5","HAVCR1","TNFRSF14","OAS3","PLSCR1","APOBEC3F","TNF","CD86","CCR5","MX1","CCL2","ITGB7","CXCL8","UVRAG","TRIM21","ADAR","ISG15","GAS6","TRIM25"]} {"pathway":"GO_RESPONSE_TO_OLEIC_ACID","pval":0.35893,"padj":0.89036,"ES":0.93267,"NES":1.24715,"nMoreExtreme":19263,"size":6,"leadingEdge":["ACSL1","DGAT2","ASS1","BAD"]} {"pathway":"GO_POSITIVE_REGULATION_OF_RECEPTOR_CLUSTERING","pval":0.51484,"padj":0.92459,"ES":0.90652,"NES":1.24699,"nMoreExtreme":27241,"size":5,"leadingEdge":["TGFB1","PTN","SSH1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_POSTSYNAPTIC_MEMBRANE_ORGANIZATION","pval":0.51514,"padj":0.92459,"ES":0.90647,"NES":1.24691,"nMoreExtreme":27257,"size":5,"leadingEdge":["PTN","SSH1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NEUROMUSCULAR_JUNCTION_DEVELOPMENT","pval":0.51514,"padj":0.92459,"ES":0.90647,"NES":1.24691,"nMoreExtreme":27257,"size":5,"leadingEdge":["PTN","MESD"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY","pval":0.05026,"padj":0.55311,"ES":0.71272,"NES":1.24673,"nMoreExtreme":4431,"size":216,"leadingEdge":["GBP5","AIM2","PLEK","ICAM1","BCL2L11","SCIN","PMAIP1","TRABD2A","TNF","ACTR3C","P2RY12","PAK1","SRC","TGFB1","CDC42EP2","TPPP","AP1AR"]} {"pathway":"GO_REGULATION_OF_B_CELL_DIFFERENTIATION","pval":0.15123,"padj":0.75292,"ES":0.91924,"NES":1.24673,"nMoreExtreme":9577,"size":24,"leadingEdge":["CYLD","SLAMF8","PTPRC","NFAM1","BAD"]} {"pathway":"GO_POLYAMINE_TRANSPORT","pval":0.22614,"padj":0.81244,"ES":0.95303,"NES":1.24664,"nMoreExtreme":12291,"size":7,"leadingEdge":["ATP13A2","AZIN2","OAZ1"]} {"pathway":"GO_REGULATION_OF_DOPAMINE_RECEPTOR_SIGNALING_PATHWAY","pval":0.22711,"padj":0.81329,"ES":0.95287,"NES":1.24643,"nMoreExtreme":12344,"size":7,"leadingEdge":["LRRK2","DTNBP1","VPS35"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_OLIGOMERIZATION","pval":0.09755,"padj":0.66591,"ES":0.94394,"NES":1.24619,"nMoreExtreme":6029,"size":20,"leadingEdge":["AIM2","BCL2L11","PMAIP1","TRABD2A","BID"]} {"pathway":"GO_LATE_ENDOSOME_TO_LYSOSOME_TRANSPORT","pval":0.22853,"padj":0.81508,"ES":0.95262,"NES":1.2461,"nMoreExtreme":12421,"size":7,"leadingEdge":["LRRK2","C9orf72","VPS41"]} {"pathway":"GO_PURINE_NUCLEOBASE_METABOLIC_PROCESS","pval":0.3649,"padj":0.89036,"ES":0.9318,"NES":1.24598,"nMoreExtreme":19583,"size":6,"leadingEdge":["ACPP","KDM1A"]} {"pathway":"GO_THIAMINE_CONTAINING_COMPOUND_METABOLIC_PROCESS","pval":0.3649,"padj":0.89036,"ES":0.9318,"NES":1.24598,"nMoreExtreme":19583,"size":6,"leadingEdge":["ACPP","SLC19A2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ALPHA_BETA_T_CELL_PROLIFERATION","pval":0.14909,"padj":0.75097,"ES":0.96533,"NES":1.24597,"nMoreExtreme":8214,"size":8,"leadingEdge":["CD274","TNFRSF14","ITCH"]} {"pathway":"GO_HETEROTYPIC_CELL_CELL_ADHESION","pval":0.13771,"padj":0.73301,"ES":0.82455,"NES":1.24595,"nMoreExtreme":9641,"size":48,"leadingEdge":["ITGA7","GLDN","VCAM1","KLF4","IL1RN","NRCAM","TNF","CD47","PTPRC","ITGB7","FLOT1"]} {"pathway":"GO_ER_OVERLOAD_RESPONSE","pval":0.04152,"padj":0.51963,"ES":0.98381,"NES":1.24583,"nMoreExtreme":2394,"size":12,"leadingEdge":["BCL2L11","HSPA5"]} {"pathway":"GO_REGULATION_OF_MAST_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE","pval":0.17664,"padj":0.77529,"ES":0.90731,"NES":1.24568,"nMoreExtreme":11301,"size":26,"leadingEdge":["LYN","FCER1G","CD84","FGR"]} {"pathway":"GO_REGULATION_OF_SIGNALING_RECEPTOR_ACTIVITY","pval":0.02742,"padj":0.41718,"ES":0.69612,"NES":1.24565,"nMoreExtreme":2562,"size":342,"leadingEdge":["IL18BP","CXCL11","IL15","IL32","CXCL10","CCL13","HGF","TNFSF10","SECTM1","CXCL9","DKK2","AGT","TNFSF13B","CCL7","IL27","TYMP","CCL15","FLT3LG","TNFSF18","CCL8","RASGRF1","EDN1","VEGFC","NCF1","IL1RN","CCL18","CCL5","IL12A","CSF1","LTA","IL7","ANXA3","CXCL16","CD70","NRG4","IL6","FGF10","LTB","TNF","EBI3","ADM2","VGF","CCL1","LY6E","CXCL12","CCL4","INSL4","CCL2","MACC1","NRG2","SRC","TGFB1","CDC42EP2","CCL19","CXCL8","NAMPT","ADA2","IL17C","ACTN2","GAS6","CCL3","CX3CL1","RGS9","IL33"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_EXOCYTOSIS","pval":0.17122,"padj":0.77295,"ES":0.88236,"NES":1.24554,"nMoreExtreme":11208,"size":31,"leadingEdge":["HLA-F","CEACAM1","RSC1A1","TRIM9","CD84"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ACTIVATED_T_CELL_PROLIFERATION","pval":0.09393,"padj":0.66439,"ES":0.97511,"NES":1.24551,"nMoreExtreme":5248,"size":9,"leadingEdge":["CD274","PDCD1LG2","BTN2A2"]} {"pathway":"GO_VESICLE_ORGANIZATION","pval":0.0348,"padj":0.47667,"ES":0.70077,"NES":1.24548,"nMoreExtreme":3192,"size":294,"leadingEdge":["TAP2","TAP1","P2RX7","SNX10","STX11","SAMD9L","TAPBP","PRRT2","RAB20","S100A10","DYSF","CHMP4C","DTNBP1","CTSZ","TRIM9","UVRAG","CTSC","SAMD9","SORT1","PLEKHF1","DNAJC13","NAPA","RAB38","STX3","RAB39A","STX17"]} {"pathway":"GO_REGULATION_OF_RESPONSE_TO_INTERFERON_GAMMA","pval":0.09943,"padj":0.66778,"ES":0.9433,"NES":1.24535,"nMoreExtreme":6145,"size":20,"leadingEdge":["SOCS1","NLRC5","STAT1","JAK2","PARP14","PARP9","NR1H3","SOCS3","PTPN2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELL_SIZE","pval":0.09479,"padj":0.6659,"ES":0.97488,"NES":1.24522,"nMoreExtreme":5296,"size":9,"leadingEdge":["EDN1","KDM1A"]} {"pathway":"GO_MYOBLAST_FUSION","pval":0.17825,"padj":0.77529,"ES":0.90695,"NES":1.24518,"nMoreExtreme":11404,"size":26,"leadingEdge":["CXCL10","CXCL9","MYOF","FLT3LG","PLEKHO1","ADGRB1","RIPOR2","CFLAR","CD53","FLOT1","WNT1","EHD1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_KINASE_A_SIGNALING","pval":0.37097,"padj":0.89036,"ES":0.93096,"NES":1.24485,"nMoreExtreme":19909,"size":6,"leadingEdge":["AKAP12","TCIM"]} {"pathway":"GO_PROTEIN_COMPLEX_OLIGOMERIZATION","pval":0.01925,"padj":0.35444,"ES":0.69044,"NES":1.24457,"nMoreExtreme":1832,"size":420,"leadingEdge":["TIFA","GBP5","AIM2","GBP1","CD74","P2RX7","GCH1","NOD2","KCTD14","STEAP4","DPYS","KCNJ2","MCOLN2","CAMK2D","BCL2L11","TGM2","GSDMD","TRIM22","ZC3H12A","P2RX4","PMAIP1","S100A10","HLA-G","CCL5","GLUL","TRABD2A","NPM2","SOD2","TNFAIP3","BIRC3","DECR1","TRIM72","RASGRP1","SMPD3","ANGPTL4","SRC","SLC22A1","TRIM21","IKBKE","ACTN2","IKZF4","ACPP"]} {"pathway":"GO_REGULATION_OF_B_CELL_ACTIVATION","pval":0.09339,"padj":0.66429,"ES":0.7545,"NES":1.24447,"nMoreExtreme":7356,"size":101,"leadingEdge":["CD40","CD74","CD38","TBX21","NOD2","BANK1","CTLA4","TNFSF13B","CYLD","SLAMF8","BCL6","LYN","PARP3","IL7","TNFAIP3","IL6","PTPRC","MNDA","TGFB1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY","pval":0.18014,"padj":0.77529,"ES":0.90641,"NES":1.24444,"nMoreExtreme":11525,"size":26,"leadingEdge":["HLA-E","C3","PTAFR","DDX58","FCER1G","TICAM1","FGR"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MESENCHYMAL_CELL_APOPTOTIC_PROCESS","pval":0.52612,"padj":0.92669,"ES":0.90467,"NES":1.24444,"nMoreExtreme":27838,"size":5,"leadingEdge":["TBX1","HNF1B","HIF1A"]} {"pathway":"GO_REGULATION_OF_ENDODERMAL_CELL_DIFFERENTIATION","pval":0.52653,"padj":0.92669,"ES":0.90461,"NES":1.24436,"nMoreExtreme":27860,"size":5,"leadingEdge":["HNF1B","DKK1"]} {"pathway":"GO_GAS_HOMEOSTASIS","pval":0.15608,"padj":0.75836,"ES":0.96393,"NES":1.24415,"nMoreExtreme":8599,"size":8,"leadingEdge":["SOD2","GSTP1"]} {"pathway":"GO_MUCOPOLYSACCHARIDE_METABOLIC_PROCESS","pval":0.04335,"padj":0.52235,"ES":0.9815,"NES":1.24374,"nMoreExtreme":2524,"size":13,"leadingEdge":["IL15","HGF","PIM1","DCN"]} {"pathway":"GO_INTEGRIN_MEDIATED_SIGNALING_PATHWAY","pval":0.10249,"padj":0.67367,"ES":0.76416,"NES":1.24358,"nMoreExtreme":7895,"size":89,"leadingEdge":["CEACAM1","PLEK","ITGA7","TSPAN32","FYB1","SEMA7A","CD47","ITGAL","ITGB7","SRC","FCER1G"]} {"pathway":"GO_EXOCYTOSIS","pval":0.0031,"padj":0.13099,"ES":0.68131,"NES":1.24357,"nMoreExtreme":306,"size":767,"leadingEdge":["P2RX7","LRRK2","SERPING1","HLA-F","CEACAM1","ADGRE5","PLEK","TNFAIP2","HGF","SELL","STX11","ATP13A2","PADI2","GRIN3A","FGL2","ERC2","EXOC3L4","LILRB3","ENPP4","GSDMD","PRRT2","B2M","CCL8","C3","S100A13","CTSS","LGALS3BP","SCIN","SCG3","RALB","VEGFC","IGF2R","MVP","EXOC3L1","DYNLT1","CCL5","LYN","DTNBP1","TNFAIP6","MMP25","SYNGR3","TICAM2","CADPS2","NR4A3","ANXA3","CTSZ","CLEC4D","RSC1A1","PSMA2","TRIM72","CD47","RASGRP1","SMPD3","RAB24","ITGAL","PTPRC","CHI3L1","PTAFR","FPR2","CACNA1I","TUBA4A","PAK1","TRIM9","MNDA","TGFB1","ARHGAP17","A2M","SYT5","PSMA5","ADA2","CTSC","GM2A","CREG1","HVCN1","ACTN2","GAS6","CCL3","ACPP","SLC44A2","SRCIN1","DNAJC13","SERPINB1","CD53","ENDOD1","PDGFB","GNS","NAPA","STX3","SYT17","CRISPLD2","STOM","NFAM1","FCER1G"]} {"pathway":"GO_REGULATION_OF_POTASSIUM_ION_TRANSPORT","pval":0.12059,"padj":0.7062,"ES":0.79129,"NES":1.24337,"nMoreExtreme":8848,"size":65,"leadingEdge":["ATP1B2","KCNJ2","ANK2","KCNE5","RNF207","KCNE1","ACTN2","MIR212","KCNE1B","KCNMB1"]} {"pathway":"GO_REGULATION_OF_CARDIOBLAST_DIFFERENTIATION","pval":0.53084,"padj":0.92816,"ES":0.90388,"NES":1.24336,"nMoreExtreme":28088,"size":5,"leadingEdge":["PRICKLE1","TGFB2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_4_SIGNALING_PATHWAY","pval":0.15936,"padj":0.76421,"ES":0.96331,"NES":1.24336,"nMoreExtreme":8780,"size":8,"leadingEdge":["ACOD1","LILRA2","LYN","TNFAIP3"]} {"pathway":"GO_MATERNAL_PROCESS_INVOLVED_IN_PARTURITION","pval":0.24126,"padj":0.82358,"ES":0.9505,"NES":1.24333,"nMoreExtreme":13113,"size":7,"leadingEdge":["CYP1A1","EDN1","PTAFR"]} {"pathway":"GO_REGULATION_OF_GERMINAL_CENTER_FORMATION","pval":0.15978,"padj":0.76421,"ES":0.96325,"NES":1.24328,"nMoreExtreme":8803,"size":8,"leadingEdge":["TNFSF13B","BCL6","TNFAIP3","MEF2C"]} {"pathway":"GO_REGULATION_OF_NEUTROPHIL_DEGRANULATION","pval":0.24178,"padj":0.82373,"ES":0.95039,"NES":1.24318,"nMoreExtreme":13141,"size":7,"leadingEdge":["PTAFR","PRAM1"]} {"pathway":"GO_TONIC_SMOOTH_MUSCLE_CONTRACTION","pval":0.24262,"padj":0.82387,"ES":0.95022,"NES":1.24296,"nMoreExtreme":13187,"size":7,"leadingEdge":["CD38","AGT","EDN1","EDNRA"]} {"pathway":"GO_RNA_3_END_PROCESSING","pval":0.07855,"padj":0.63581,"ES":0.73473,"NES":1.24295,"nMoreExtreme":6464,"size":134,"leadingEdge":["LIN28A","ERI1","PAF1"]} {"pathway":"GO_RESPONSE_TO_STIMULUS_INVOLVED_IN_REGULATION_OF_MUSCLE_ADAPTATION","pval":0.16139,"padj":0.76656,"ES":0.96297,"NES":1.24292,"nMoreExtreme":8892,"size":8,"leadingEdge":["AGT","HDAC4"]} {"pathway":"GO_CELLULAR_MODIFIED_AMINO_ACID_CATABOLIC_PROCESS","pval":0.06399,"padj":0.59632,"ES":0.96751,"NES":1.24292,"nMoreExtreme":3832,"size":16,"leadingEdge":["GGT5","CHAC1","GGT1"]} {"pathway":"GO_REGULATION_OF_POTASSIUM_ION_EXPORT_ACROSS_PLASMA_MEMBRANE","pval":0.38092,"padj":0.89036,"ES":0.92947,"NES":1.24286,"nMoreExtreme":20443,"size":6,"leadingEdge":["KCNE5","DLG1"]} {"pathway":"GO_REGULATION_OF_PROTEIN_K63_LINKED_UBIQUITINATION","pval":0.07028,"padj":0.61935,"ES":0.97898,"NES":1.24285,"nMoreExtreme":3966,"size":10,"leadingEdge":["NOD2","PARP10","UBR5"]} {"pathway":"GO_DOPAMINE_BIOSYNTHETIC_PROCESS","pval":0.24371,"padj":0.82387,"ES":0.95005,"NES":1.24274,"nMoreExtreme":13246,"size":7,"leadingEdge":["GCH1","NR4A2","VPS35"]} {"pathway":"GO_RESPONSE_TO_TESTOSTERONE","pval":0.16097,"padj":0.76631,"ES":0.85898,"NES":1.24274,"nMoreExtreme":10782,"size":36,"leadingEdge":["XRN1","EDN1","CFLAR","NKX3-1","BAD"]} {"pathway":"GO_RIGHTING_REFLEX","pval":0.24435,"padj":0.82387,"ES":0.94994,"NES":1.2426,"nMoreExtreme":13281,"size":7,"leadingEdge":["AUTS2","USP46"]} {"pathway":"GO_PHOTOTRANSDUCTION_VISIBLE_LIGHT","pval":0.09634,"padj":0.66591,"ES":0.9476,"NES":1.24257,"nMoreExtreme":5916,"size":19,"leadingEdge":["GUCA1A","CNGB1"]} {"pathway":"GO_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE","pval":0.05668,"padj":0.57014,"ES":0.7134,"NES":1.24249,"nMoreExtreme":4947,"size":201,"leadingEdge":["NOD2","HGF","RIPK2","FAS","ZC3H12A","CYLD","EDN1","SLAMF1","NCF1","NRK","IL1RN","GADD45B","LYN","DTNBP1","TLR3","GADD45G","TNF","DUSP10","RASGRP1","FGD2","PAK1","CCL19","PRDX1","PTPN1","SH3RF1","BIRC7","PLCB1"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_VACUOLE","pval":0.13362,"padj":0.72971,"ES":0.80932,"NES":1.24239,"nMoreExtreme":9510,"size":54,"leadingEdge":["GBP1","TNFAIP3","SNX16","NCOA4","GCC2","M6PR"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CREB_TRANSCRIPTION_FACTOR_ACTIVITY","pval":0.53659,"padj":0.92816,"ES":0.90301,"NES":1.24216,"nMoreExtreme":28392,"size":5,"leadingEdge":["SIK1","MSX2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INTERLEUKIN_12_PRODUCTION","pval":0.191,"padj":0.79001,"ES":0.89926,"NES":1.24215,"nMoreExtreme":12280,"size":27,"leadingEdge":["IRF1","IDO1","CD40","RIPK2","HLA-G","TLR3","LTB","CCL19","IRF5","PLCB1","IRF8","TLR4"]} {"pathway":"GO_EMBRYONIC_PROCESS_INVOLVED_IN_FEMALE_PREGNANCY","pval":0.53683,"padj":0.92816,"ES":0.90293,"NES":1.24205,"nMoreExtreme":28405,"size":5,"leadingEdge":["JUNB","ACSL4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MRNA_CATABOLIC_PROCESS","pval":0.14617,"padj":0.74879,"ES":0.82956,"NES":1.24201,"nMoreExtreme":10147,"size":45,"leadingEdge":["ZC3H12A","GTPBP1","MOV10","TRIM71","ZFP36","PRR5L","PLEKHN1","BTG2","UPF1"]} {"pathway":"GO_PROTEASOME_ASSEMBLY","pval":0.04693,"padj":0.53858,"ES":0.9801,"NES":1.24196,"nMoreExtreme":2732,"size":13,"leadingEdge":["POMP","PSMD5"]} {"pathway":"GO_ESTABLISHMENT_OF_ENDOTHELIAL_INTESTINAL_BARRIER","pval":0.07322,"padj":0.62434,"ES":0.97825,"NES":1.24193,"nMoreExtreme":4132,"size":10,"leadingEdge":["ICAM1","RAPGEF2","TJP1"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_INTERFERON_BETA","pval":0.09781,"padj":0.66591,"ES":0.9471,"NES":1.2419,"nMoreExtreme":6006,"size":19,"leadingEdge":["IRF1","AIM2","ACOD1","STAT1","PYHIN1","TLR3","MNDA"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INTERFERON_GAMMA_SECRETION","pval":0.36649,"padj":0.89036,"ES":0.83262,"NES":1.2419,"nMoreExtreme":18416,"size":2,"leadingEdge":["ZC3H12A"]} {"pathway":"GO_IMPORT_ACROSS_PLASMA_MEMBRANE","pval":0.10674,"padj":0.68464,"ES":0.76653,"NES":1.24189,"nMoreExtreme":8172,"size":85,"leadingEdge":["ATP1B2","KCNJ10","AGT","SLC12A3","KCNJ2","KCNJ15","SLC8A1","SLC12A7","SLC7A2","SLC31A1","SLC9A4"]} {"pathway":"GO_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE","pval":0.04183,"padj":0.51963,"ES":0.70148,"NES":1.24173,"nMoreExtreme":3799,"size":270,"leadingEdge":["NOD2","HGF","AGT","RIPK2","FAS","ZC3H12A","CYLD","EDN1","SLAMF1","NCF1","NRK","IL1RN","GADD45B","PTGER4","LYN","DTNBP1","TLR3","GADD45G","TNF","CUL1","DUSP10","RASGRP1","FGD2","PAK1","CCL19","PRDX1","PTPN1","SH3RF1","BIRC7","PLCB1","ZFP36","MAP3K8","TLR4","MAPK8IP2"]} {"pathway":"GO_ADULT_HEART_DEVELOPMENT","pval":0.16646,"padj":0.77278,"ES":0.96202,"NES":1.24169,"nMoreExtreme":9171,"size":8,"leadingEdge":["MYH7","MNAT1"]} {"pathway":"GO_GLYCOPROTEIN_CATABOLIC_PROCESS","pval":0.09836,"padj":0.66671,"ES":0.94689,"NES":1.24164,"nMoreExtreme":6040,"size":19,"leadingEdge":["FBXO6","EDEM1","EDEM2"]} {"pathway":"GO_REGULATION_OF_EPIDERMAL_GROWTH_FACTOR_ACTIVATED_RECEPTOR_ACTIVITY","pval":0.17989,"padj":0.77529,"ES":0.90985,"NES":1.24161,"nMoreExtreme":11459,"size":25,"leadingEdge":["NCF1","EREG","GPRC5A"]} {"pathway":"GO_REGULATION_OF_ANION_CHANNEL_ACTIVITY","pval":0.24925,"padj":0.82387,"ES":0.94914,"NES":1.24154,"nMoreExtreme":13547,"size":7,"leadingEdge":["ABCB1","PTAFR","ANO9"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION_INVOLVED_IN_PROSTATE_GLAND_DEVELOPMENT","pval":0.38722,"padj":0.89277,"ES":0.92843,"NES":1.24147,"nMoreExtreme":20781,"size":6,"leadingEdge":["NKX3-1","CDKN1B"]} {"pathway":"GO_NOTCH_RECEPTOR_PROCESSING_LIGAND_DEPENDENT","pval":0.2496,"padj":0.82387,"ES":0.94904,"NES":1.24142,"nMoreExtreme":13566,"size":7,"leadingEdge":["PSEN2","PSEN1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_VASCULAR_ASSOCIATED_SMOOTH_MUSCLE_CELL_MIGRATION","pval":0.38767,"padj":0.89277,"ES":0.92837,"NES":1.24139,"nMoreExtreme":20805,"size":6,"leadingEdge":["MIR503","NFE2L2","MEF2C"]} {"pathway":"GO_POSITIVE_REGULATION_OF_STRIATED_MUSCLE_CONTRACTION","pval":0.16835,"padj":0.77295,"ES":0.96162,"NES":1.24118,"nMoreExtreme":9275,"size":8,"leadingEdge":["RNF207","KCNQ1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_EXECUTION_PHASE_OF_APOPTOSIS","pval":0.04893,"padj":0.54844,"ES":0.97937,"NES":1.24104,"nMoreExtreme":2849,"size":13,"leadingEdge":["ZC3H12A","SIRT2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_T_HELPER_1_TYPE_IMMUNE_RESPONSE","pval":0.38953,"padj":0.8943,"ES":0.92809,"NES":1.24102,"nMoreExtreme":20905,"size":6,"leadingEdge":["JAK3","IL33","IL4R"]} {"pathway":"GO_POSITIVE_REGULATION_OF_APOPTOTIC_CELL_CLEARANCE","pval":0.25182,"padj":0.82744,"ES":0.9487,"NES":1.24098,"nMoreExtreme":13687,"size":7,"leadingEdge":["C4A","C4B","C2","C3","CD300LF","CCL2"]} {"pathway":"GO_REGULATION_OF_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS","pval":0.07825,"padj":0.63581,"ES":0.73114,"NES":1.24088,"nMoreExtreme":6484,"size":140,"leadingEdge":["LRRK2","NUB1","PML","RNF19B","PYHIN1","RNF144B","GCLC","NFE2L2","IL33","HERPUD1","RNF19A","WNT1","PRICKLE1"]} {"pathway":"GO_EXOCYST_LOCALIZATION","pval":0.11066,"padj":0.69745,"ES":0.97146,"NES":1.24084,"nMoreExtreme":6183,"size":9,"leadingEdge":["TNFAIP2","EXOC3L4","RALB","EXOC3L1","EXOC1"]} {"pathway":"GO_REGULATION_OF_MRNA_CATABOLIC_PROCESS","pval":0.06321,"padj":0.59455,"ES":0.71682,"NES":1.24081,"nMoreExtreme":5445,"size":183,"leadingEdge":["PSME2","PSMB9","PSME1","PSMB10","PSMB8","XRN1","SAMD4A","ZC3H12A","GTPBP1","MYD88","PSMA4","PSMA2","MOV10","TRIM71","PSMA5"]} {"pathway":"GO_ALDITOL_METABOLIC_PROCESS","pval":0.11093,"padj":0.69778,"ES":0.9714,"NES":1.24077,"nMoreExtreme":6198,"size":9,"leadingEdge":["GK","MYOF","DGAT2","DYSF"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEOLYSIS_INVOLVED_IN_CELLULAR_PROTEIN_CATABOLIC_PROCESS","pval":0.09079,"padj":0.66096,"ES":0.7443,"NES":1.24075,"nMoreExtreme":7283,"size":113,"leadingEdge":["LRRK2","NUB1","RNF19B","PYHIN1","EDEM1","RNF144B","GCLC","CTSC","NFE2L2","IL33","HERPUD1","NUPR1","RNF19A","EDEM2","PRICKLE1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS","pval":0.10087,"padj":0.67298,"ES":0.94614,"NES":1.24065,"nMoreExtreme":6194,"size":19,"leadingEdge":["AGT","PAK1","SRC","PRKCZ"]} {"pathway":"GO_STEROID_ESTERIFICATION","pval":0.0777,"padj":0.63581,"ES":0.97721,"NES":1.2406,"nMoreExtreme":4385,"size":10,"leadingEdge":["AGT","SOAT1","APOA1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_DEACETYLATION","pval":0.10103,"padj":0.67298,"ES":0.94608,"NES":1.24058,"nMoreExtreme":6204,"size":19,"leadingEdge":["LRRK2","BCL6","TGFB1","AKAP8L"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_EXTRACELLULAR_STIMULUS","pval":0.05081,"padj":0.55505,"ES":0.70671,"NES":1.24049,"nMoreExtreme":4519,"size":230,"leadingEdge":["P2RX7","LRRK2","IL15","ATF3","PIM1","FAS","VCAM1","ICAM1","GSDMD","ZC3H12A","P2RX4","RALB","FAM107A","PMAIP1","LYN","GLUL","CADPS2","NCOA1","CYP27B1","PTPRC","NR4A2","SIK1B","P2RY12","NUAK2","CDKN1A","UCP2","NAMPT","RRAGC","P2RY2","PTGS2","GAS6","ASNS","RRAGD","NFE2L2"]} {"pathway":"GO_REGULATION_OF_ATRIAL_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL","pval":0.54335,"padj":0.93043,"ES":0.90175,"NES":1.24043,"nMoreExtreme":28750,"size":5,"leadingEdge":["ANK2","RNF207","TRPM4"]} {"pathway":"GO_CARDIOBLAST_PROLIFERATION","pval":0.11284,"padj":0.69864,"ES":0.97106,"NES":1.24034,"nMoreExtreme":6305,"size":9,"leadingEdge":["PIM1","SIX1","MKS1"]} {"pathway":"GO_RESPONSE_TO_INTERLEUKIN_9","pval":0.25513,"padj":0.82758,"ES":0.9482,"NES":1.24032,"nMoreExtreme":13867,"size":7,"leadingEdge":["STAT1","JAK3","IL2RG","STAT5A","STAT3"]} {"pathway":"GO_EMBRYONIC_PLACENTA_MORPHOGENESIS","pval":0.11397,"padj":0.69895,"ES":0.93933,"NES":1.24012,"nMoreExtreme":7044,"size":20,"leadingEdge":["NCOA1","SOCS3","CDKN1C","FGFR2"]} {"pathway":"GO_REGULATION_OF_NATURAL_KILLER_CELL_ACTIVATION","pval":0.19442,"padj":0.79001,"ES":0.89775,"NES":1.24006,"nMoreExtreme":12500,"size":27,"leadingEdge":["IL15","HLA-F","HLA-E","FLT3LG","IL12A","RASGRP1","GAS6","TICAM1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_ACTIVITY","pval":0.39411,"padj":0.89503,"ES":0.92736,"NES":1.24004,"nMoreExtreme":21151,"size":6,"leadingEdge":["MIR212","ATP2B4"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PEPTIDYL_CYSTEINE_S_NITROSYLATION","pval":0.39411,"padj":0.89503,"ES":0.92736,"NES":1.24004,"nMoreExtreme":21151,"size":6,"leadingEdge":["MIR212","ATP2B4"]} {"pathway":"GO_FUNGIFORM_PAPILLA_MORPHOGENESIS","pval":0.5449,"padj":0.93088,"ES":0.90147,"NES":1.24004,"nMoreExtreme":28832,"size":5,"leadingEdge":["SIX1","SIX4"]} {"pathway":"GO_LEPTIN_MEDIATED_SIGNALING_PATHWAY","pval":0.25688,"padj":0.82758,"ES":0.94797,"NES":1.24002,"nMoreExtreme":13962,"size":7,"leadingEdge":["STAT3","SIRT1"]} {"pathway":"GO_REGULATION_OF_MITOCHONDRIAL_FISSION","pval":0.12836,"padj":0.72213,"ES":0.93266,"NES":1.23987,"nMoreExtreme":7988,"size":21,"leadingEdge":["LRRK2","STAT2","DDHD1","DCN"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_POTENTIAL","pval":0.11479,"padj":0.70006,"ES":0.97061,"NES":1.23977,"nMoreExtreme":6414,"size":9,"leadingEdge":["CTNS","BAD"]} {"pathway":"GO_RESPONSE_TO_MITOCHONDRIAL_DEPOLARISATION","pval":0.11533,"padj":0.70006,"ES":0.93903,"NES":1.23972,"nMoreExtreme":7128,"size":20,"leadingEdge":["OPTN","MUL1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_AUTOPHAGY_OF_MITOCHONDRION","pval":0.11533,"padj":0.70006,"ES":0.93903,"NES":1.23972,"nMoreExtreme":7128,"size":20,"leadingEdge":["OPTN","VPS13D"]} {"pathway":"GO_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR","pval":0.17805,"padj":0.77529,"ES":0.87821,"NES":1.23969,"nMoreExtreme":11655,"size":31,"leadingEdge":["CD74","PMAIP1","PYHIN1","HIC1","KDM1A"]} {"pathway":"GO_CIRCADIAN_REGULATION_OF_GENE_EXPRESSION","pval":0.14301,"padj":0.74198,"ES":0.81815,"NES":1.23963,"nMoreExtreme":10034,"size":49,"leadingEdge":["BHLHE41","PML","RELB","NAMPT","HNF1B"]} {"pathway":"GO_NEUTROPHIL_APOPTOTIC_PROCESS","pval":0.17475,"padj":0.77529,"ES":0.96039,"NES":1.23959,"nMoreExtreme":9628,"size":8,"leadingEdge":["HCAR2","IL6","PIK3CB"]} {"pathway":"GO_POSITIVE_REGULATION_OF_GUANYLATE_CYCLASE_ACTIVITY","pval":0.25918,"padj":0.82758,"ES":0.94764,"NES":1.23958,"nMoreExtreme":14087,"size":7,"leadingEdge":["GUCA1A","NOS2"]} {"pathway":"GO_REGULATION_OF_GUANYLATE_CYCLASE_ACTIVITY","pval":0.25918,"padj":0.82758,"ES":0.94764,"NES":1.23958,"nMoreExtreme":14087,"size":7,"leadingEdge":["GUCA1A","NOS2"]} {"pathway":"GO_INTERLEUKIN_4_MEDIATED_SIGNALING_PATHWAY","pval":0.25949,"padj":0.82787,"ES":0.94758,"NES":1.23951,"nMoreExtreme":14104,"size":7,"leadingEdge":["CD300LF","JAK3","PARP14","IL2RG","PTPN2","IL4R"]} {"pathway":"GO_EMBRYONIC_EYE_MORPHOGENESIS","pval":0.18663,"padj":0.78157,"ES":0.90827,"NES":1.23946,"nMoreExtreme":11888,"size":25,"leadingEdge":["VAX2","PROX1","HIPK2"]} {"pathway":"GO_POSITIVE_THYMIC_T_CELL_SELECTION","pval":0.2603,"padj":0.82935,"ES":0.94747,"NES":1.23936,"nMoreExtreme":14148,"size":7,"leadingEdge":["CD74","PTPRC","PTPN2"]} {"pathway":"GO_RETROGRADE_TRANSPORT_ENDOSOME_TO_GOLGI","pval":0.11295,"padj":0.69864,"ES":0.77081,"NES":1.23932,"nMoreExtreme":8551,"size":79,"leadingEdge":["LRRK2","RHOBTB3","SNX8","DENND5A","GCC2"]} {"pathway":"GO_FUCOSE_CATABOLIC_PROCESS","pval":0.54817,"padj":0.93125,"ES":0.9009,"NES":1.23926,"nMoreExtreme":29005,"size":5,"leadingEdge":["FUT4","FUT1","FUT8"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION","pval":0.07725,"padj":0.63581,"ES":0.7276,"NES":1.23909,"nMoreExtreme":6442,"size":146,"leadingEdge":["IL31RA","CD40","CD74","IL15","HGF","BANK1","JAK2","AGT","RIPK2","ICAM1","TNFSF18","CD80","STAP1","ENPP2","NCF1","STAP2","CCL5","LYN","IL12A","PARP14","TNFRSF14","PARP9","IL6","FGF10","TNF","PTPRC","SOCS3","STAT3","SRC","TGFB1","PTPN1","GAS6","SRCIN1","SEMA4D","PDGFB"]} {"pathway":"GO_CONTACT_INHIBITION","pval":0.26264,"padj":0.83229,"ES":0.94708,"NES":1.23885,"nMoreExtreme":14275,"size":7,"leadingEdge":["PAK1","FAP"]} {"pathway":"GO_LEUKOCYTE_ACTIVATION_INVOLVED_IN_INFLAMMATORY_RESPONSE","pval":0.1654,"padj":0.77043,"ES":0.85616,"NES":1.23866,"nMoreExtreme":11079,"size":36,"leadingEdge":["LRRK2","TLR8","STAP1","TLR7","IL6","TLR3","TNF","PTPRC","FPR2","NAMPT","CCL3","CX3CL1","IL33"]} {"pathway":"GO_CELL_CELL_ADHESION","pval":0.00765,"padj":0.22918,"ES":0.68033,"NES":1.23842,"nMoreExtreme":749,"size":639,"leadingEdge":["IRF1","HLA-DPA1","IDO1","HLA-DMB","CD74","SOCS1","CD274","IL12RB1","PDCD1LG2","IL15","LAG3","HLA-DPB1","TBX21","NOD2","CEACAM1","PLEK","SELL","HLA-E","CTLA4","JAK2","ITGA7","RIPK2","TNFSF13B","GLDN","VCAM1","ICAM1","MDGA1","KLF4","CD80","PDCD1","TSPAN32","ZC3H12A","JAK3","CYLD","ICAM2","BTN2A2","IL1RN","COMP","HLA-G","MPZL2","BCL6","CCL5","LYN","IL12A","NR4A3","TNFRSF14","IL7","NRCAM","PTPRU","CD83","ANXA3","ICAM4","IL6","LILRB4","EGR3","TNF","EBI3","DUSP10","CD86","CD47","RASGRP1","ITGAL","NTN1","CXCL12","PTPRC","PTAFR","LILRB1","CCL2","P2RY12","PTPN2","ITGB7","PAK1","PODXL","RUNX1","SRC","TGFB1","NTNG2","ICOS","CCDC88B","ROBO1","IL2RA","CCL19","GP1BA","PDGFRA","PKHD1","RIPOR2","ASTN1","HAS2","GAS6","CX3CL1"]} {"pathway":"GO_NUCLEOTIDE_TRANSPORT","pval":0.09556,"padj":0.66591,"ES":0.95087,"NES":1.23837,"nMoreExtreme":5813,"size":18,"leadingEdge":["P2RX7","ABCC11","SLC25A25","SLC25A5"]} {"pathway":"GO_SECONDARY_ALCOHOL_METABOLIC_PROCESS","pval":0.12791,"padj":0.72213,"ES":0.79262,"NES":1.23819,"nMoreExtreme":9315,"size":62,"leadingEdge":["APOL1","APOL2","SOAT1","TTC39B","DGAT2","CH25H","CYP27B1","CES1","ERLIN1","LMF1","NPC1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY","pval":0.05163,"padj":0.55686,"ES":0.70499,"NES":1.23818,"nMoreExtreme":4598,"size":233,"leadingEdge":["AIM2","CD40","NOD2","RHEBL1","JAK2","AGT","RIPK2","ICAM1","TNFSF18","TRIM22","CARD16","EDN1","TRIM31","ANXA3","MYD88","IL6","TLR3","NFKB2","TNF","RBCK1","CAMK1D","DDX58","STAT3","TGFB1","TRIM21","CX3CL1","TRIM25","CFLAR","NKX3-1","PPARGC1B","SMAD3","TRAF1","NFAM1","ARID5B","FLOT1","TLR4","IL18RAP"]} {"pathway":"GO_RESPONSE_TO_IMMUNE_RESPONSE_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION","pval":0.55303,"padj":0.93341,"ES":0.90006,"NES":1.23811,"nMoreExtreme":29262,"size":5,"leadingEdge":["GUCY1A1","EIF2AK2"]} {"pathway":"GO_RELAXATION_OF_MUSCLE","pval":0.18108,"padj":0.77555,"ES":0.91286,"NES":1.23807,"nMoreExtreme":11467,"size":24,"leadingEdge":["PDE4B","KCNJ2","CAMK2D","SRI","P2RX4","TIFAB","SLC8A1","KCNMA1","GUCY1A1","NEUROG1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_RENAL_SODIUM_EXCRETION","pval":0.18121,"padj":0.77567,"ES":0.95911,"NES":1.23794,"nMoreExtreme":9984,"size":8,"leadingEdge":["AGT","NPR1","EDN1","ADORA2A"]} {"pathway":"GO_PEROXISOMAL_TRANSPORT","pval":0.12814,"padj":0.72213,"ES":0.79238,"NES":1.23781,"nMoreExtreme":9332,"size":62,"leadingEdge":["ACOT4","GSTK1","CROT"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_FOLLICLE_STIMULATING_HORMONE_STIMULUS","pval":0.26786,"padj":0.83635,"ES":0.94623,"NES":1.23775,"nMoreExtreme":14559,"size":7,"leadingEdge":["GCLC","GCLM"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELLULAR_EXTRAVASATION","pval":0.40537,"padj":0.89503,"ES":0.92562,"NES":1.23771,"nMoreExtreme":21755,"size":6,"leadingEdge":["PTGER4","CXCL12","PLCB1"]} {"pathway":"GO_VASCULAR_ASSOCIATED_SMOOTH_MUSCLE_CELL_MIGRATION","pval":0.15261,"padj":0.75292,"ES":0.92448,"NES":1.23771,"nMoreExtreme":9548,"size":22,"leadingEdge":["AGT","MIR503","NR4A3","PAK1","NFE2L2","PDGFB"]} {"pathway":"GO_REGULATION_OF_NON_MEMBRANE_SPANNING_PROTEIN_TYROSINE_KINASE_ACTIVITY","pval":0.26891,"padj":0.83693,"ES":0.94612,"NES":1.2376,"nMoreExtreme":14616,"size":7,"leadingEdge":["STAP1","SRC","FYN"]} {"pathway":"GO_PROGRAMMED_NECROTIC_CELL_DEATH","pval":0.16015,"padj":0.76421,"ES":0.84445,"NES":1.23754,"nMoreExtreme":10877,"size":39,"leadingEdge":["FAS","CYLD","TICAM2","BIRC3","TLR3","TNF","RBCK1","CFLAR","TLR4","TICAM1","MLKL"]} {"pathway":"GO_PROGESTERONE_RECEPTOR_SIGNALING_PATHWAY","pval":0.26924,"padj":0.83693,"ES":0.94606,"NES":1.23753,"nMoreExtreme":14634,"size":7,"leadingEdge":["SRC","NEDD4"]} {"pathway":"GO_REGULATION_OF_BLOOD_VESSEL_REMODELING","pval":0.26924,"padj":0.83693,"ES":0.94606,"NES":1.23753,"nMoreExtreme":14634,"size":7,"leadingEdge":["CEACAM1","TGFB1","FLT4"]} {"pathway":"GO_DEVELOPMENT_OF_SECONDARY_FEMALE_SEXUAL_CHARACTERISTICS","pval":0.26952,"padj":0.83695,"ES":0.94601,"NES":1.23745,"nMoreExtreme":14649,"size":7,"leadingEdge":["TGFB1","AREG"]} {"pathway":"GO_REGULATION_OF_CELLULAR_RESPONSE_TO_DRUG","pval":0.19294,"padj":0.79001,"ES":0.9068,"NES":1.23745,"nMoreExtreme":12290,"size":25,"leadingEdge":["LRRK2","HGF","NR4A3","TXN","NCOA1","NFE2L2","MET"]} {"pathway":"GO_STEROL_METABOLIC_PROCESS","pval":0.12393,"padj":0.71286,"ES":0.78181,"NES":1.23709,"nMoreExtreme":9172,"size":69,"leadingEdge":["APOL1","APOL2","SOAT1","TTC39B","DGAT2","CH25H","CES1","ERLIN1","LMF1","NPC1"]} {"pathway":"GO_REGULATION_OF_B_CELL_RECEPTOR_SIGNALING_PATHWAY","pval":0.171,"padj":0.77295,"ES":0.91779,"NES":1.2368,"nMoreExtreme":10758,"size":23,"leadingEdge":["STAP1","LYN","PTPRC","RUNX1","NFAM1","PAX5","CD22"]} {"pathway":"GO_MAINTENANCE_OF_LOCATION","pval":0.04491,"padj":0.5317,"ES":0.69867,"NES":1.23676,"nMoreExtreme":4078,"size":270,"leadingEdge":["P2RX7","CXCL11","CXCL10","CXCL9","MCOLN2","CAMK2D","SPTBN4","SOAT1","PML","SRI","C3","ZC3H12A","SCIN","TMSB10","ANK2","TTC39B","DGAT2","DYSF","LYN","IL6","TXN","JPH4","TNF","SLC8A1","CCR5","PTPRC","NR1H3","PTPN2","TGFB1","CCL19","UVRAG","IKBKE","GM2A","NFKBIA","CCL3","CX3CL1","PLCB1","CLIC2","NFKBIE"]} {"pathway":"GO_T_HELPER_17_TYPE_IMMUNE_RESPONSE","pval":0.15619,"padj":0.75836,"ES":0.92374,"NES":1.23671,"nMoreExtreme":9772,"size":22,"leadingEdge":["IL12RB1","TBX21","SLAMF6","ZC3H12A","IRF4","IL6","STAT3","PRKCQ"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CHEMOKINE_C_X_C_MOTIF_LIGAND_2_PRODUCTION","pval":0.18742,"padj":0.78227,"ES":0.95792,"NES":1.2364,"nMoreExtreme":10326,"size":8,"leadingEdge":["CD74","MCOLN2","TNF"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_DEFENSE_RESPONSE","pval":0.07581,"padj":0.63269,"ES":0.72179,"NES":1.23637,"nMoreExtreme":6397,"size":157,"leadingEdge":["SERPING1","HLA-F","CEACAM1","HGF","NLRC5","HLA-E","ACOD1","NMI","TRAFD1","KLF4","MEFV","ZC3H12A","HLA-G","SLAMF8","PTGER4","TNFAIP6","PARP14","TNFAIP3","SERPINB9","DUSP10","PTPRC","NR1H3","LILRB1","SOCS3","PTPN2","DHX58","A2M","IL2RA","CX3CL1","GATA3","IL1R2","SMAD3","MICB"]} {"pathway":"GO_CELLULAR_POTASSIUM_ION_HOMEOSTASIS","pval":0.27443,"padj":0.83769,"ES":0.94517,"NES":1.23635,"nMoreExtreme":14916,"size":7,"leadingEdge":["ATP1B2","KCNJ2","KCNMA1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION","pval":0.17087,"padj":0.77295,"ES":0.85822,"NES":1.2361,"nMoreExtreme":11388,"size":35,"leadingEdge":["SPTBN4","SCIN","SPTA1","CAPG"]} {"pathway":"GO_POSITIVE_REGULATION_OF_GLOMERULAR_MESANGIAL_CELL_PROLIFERATION","pval":0.41492,"padj":0.89503,"ES":0.92433,"NES":1.23599,"nMoreExtreme":22268,"size":6,"leadingEdge":["CFLAR","PDGFB","EGR1"]} {"pathway":"GO_REVERSIBLE_DIFFERENTIATION","pval":0.41492,"padj":0.89503,"ES":0.92433,"NES":1.23599,"nMoreExtreme":22268,"size":6,"leadingEdge":["SOD2","PDGFB","FGF9"]} {"pathway":"GO_POSITIVE_REGULATION_OF_VACUOLE_ORGANIZATION","pval":0.06121,"padj":0.58982,"ES":0.97527,"NES":1.23584,"nMoreExtreme":3564,"size":13,"leadingEdge":["RALB","GRN"]} {"pathway":"GO_POLYAMINE_METABOLIC_PROCESS","pval":0.09296,"padj":0.66428,"ES":0.97336,"NES":1.23572,"nMoreExtreme":5246,"size":10,"leadingEdge":["SAT1","DHPS"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ALKALINE_PHOSPHATASE_ACTIVITY","pval":0.4164,"padj":0.89503,"ES":0.9241,"NES":1.23569,"nMoreExtreme":22347,"size":6,"leadingEdge":["PPARGC1B","SMAD3","MEF2C"]} {"pathway":"GO_TRANSDIFFERENTIATION","pval":0.41669,"padj":0.89503,"ES":0.92404,"NES":1.23561,"nMoreExtreme":22363,"size":6,"leadingEdge":["SMAD3","GOT1"]} {"pathway":"GO_REGULATION_OF_ENDOSOME_SIZE","pval":0.56299,"padj":0.93517,"ES":0.89821,"NES":1.23556,"nMoreExtreme":29789,"size":5,"leadingEdge":["RILP","ALS2"]} {"pathway":"GO_PHOTORECEPTOR_CELL_MAINTENANCE","pval":0.17698,"padj":0.77529,"ES":0.91655,"NES":1.23513,"nMoreExtreme":11134,"size":23,"leadingEdge":["ESRRB","PROM1"]} {"pathway":"GO_CELL_DEATH_IN_RESPONSE_TO_HYDROGEN_PEROXIDE","pval":0.20021,"padj":0.79183,"ES":0.90502,"NES":1.23502,"nMoreExtreme":12753,"size":25,"leadingEdge":["LRRK2","HGF","NR4A3","TXN","NFE2L2","MET"]} {"pathway":"GO_CELLULAR_SODIUM_ION_HOMEOSTASIS","pval":0.19292,"padj":0.79001,"ES":0.95685,"NES":1.23502,"nMoreExtreme":10629,"size":8,"leadingEdge":["ATP1B2","AGT","SLC8A1","NEDD4L"]} {"pathway":"GO_POSITIVE_REGULATION_OF_AUTOPHAGOSOME_ASSEMBLY","pval":0.07653,"padj":0.63483,"ES":0.97527,"NES":1.235,"nMoreExtreme":4369,"size":11,"leadingEdge":["RALB","SH3GLB1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY","pval":0.11255,"padj":0.69864,"ES":0.76136,"NES":1.23481,"nMoreExtreme":8631,"size":86,"leadingEdge":["CD40","P2RX7","IL12RB1","LAG3","TBX21","HLA-F","HLA-B","HLA-E","HLA-A","HLA-C","B2M","C3","SLAMF6","RSAD2","HLA-G","IL12A","LTA","IL6","TNF","CD226","RASGRP1","PTPRC","TGFB1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE","pval":0.1163,"padj":0.70006,"ES":0.94165,"NES":1.23476,"nMoreExtreme":7142,"size":19,"leadingEdge":["TBX21","HLA-F","JAK3","BCL6","TNF","LILRB1","TGFB1","BST2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_4_SIGNALING_PATHWAY","pval":0.28258,"padj":0.84533,"ES":0.94382,"NES":1.23459,"nMoreExtreme":15359,"size":7,"leadingEdge":["TICAM2","NR1H3","WDFY1"]} {"pathway":"GO_FRUCTOSE_6_PHOSPHATE_METABOLIC_PROCESS","pval":0.19537,"padj":0.79001,"ES":0.9564,"NES":1.23444,"nMoreExtreme":10764,"size":8,"leadingEdge":["PFKP","NFE2L1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_DRUG","pval":0.19421,"padj":0.79001,"ES":0.90997,"NES":1.23416,"nMoreExtreme":12299,"size":24,"leadingEdge":["LRRK2","HGF","NR4A3","TXN","NFE2L2","MET"]} {"pathway":"GO_INTERLEUKIN_6_MEDIATED_SIGNALING_PATHWAY","pval":0.10748,"padj":0.68786,"ES":0.94761,"NES":1.23412,"nMoreExtreme":6538,"size":18,"leadingEdge":["STAT1","JAK2","IL6","SOCS3","STAT3","PTPN2"]} {"pathway":"GO_JNK_CASCADE","pval":0.06647,"padj":0.60375,"ES":0.71135,"NES":1.23412,"nMoreExtreme":5754,"size":189,"leadingEdge":["NOD2","RIPK2","CYLD","EDN1","SLAMF1","NCF1","NRK","IL1RN","GADD45B","PTGER4","DTNBP1","TLR3","GADD45G","TNF","DUSP10","RASGRP1","FGD2","PAK1","CCL19","PTPN1","SH3RF1","BIRC7","PLCB1","TLR4","MAPK8IP2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_GRANULOCYTE_DIFFERENTIATION","pval":0.28626,"padj":0.84868,"ES":0.94326,"NES":1.23385,"nMoreExtreme":15559,"size":7,"leadingEdge":["CEACAM1","C1QC"]} {"pathway":"GO_HISTONE_H2B_UBIQUITINATION","pval":0.0721,"padj":0.62163,"ES":0.9742,"NES":1.23366,"nMoreExtreme":4158,"size":12,"leadingEdge":["DTX3L","PAF1"]} {"pathway":"GO_MODIFICATION_DEPENDENT_MACROMOLECULE_CATABOLIC_PROCESS","pval":0.01225,"padj":0.28185,"ES":0.67938,"NES":1.23365,"nMoreExtreme":1191,"size":567,"leadingEdge":["UBD","PSME2","LRRK2","PSMB9","FBXO6","TBX21","PSME1","PSMB10","NUB1","IFI27","UBE2L6","PSMB8","PML","RNF19B","CYLD","DTX3L","PYHIN1","TNFAIP3","EDEM1","RNF144B","PSMA4","PSMA2","SPOPL","RBCK1","CUL1","TRIM72","UBE2A","TRIM71","TRIM9","GCLC","PSMA5","UBE2Z","ISG15","USP18","TRIM25","ERLIN1","NFE2L2","IL33","HERPUD1"]} {"pathway":"GO_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS","pval":0.10977,"padj":0.69745,"ES":0.75631,"NES":1.23365,"nMoreExtreme":8486,"size":91,"leadingEdge":["CD74","CXCL10","PADI2","CCL7","STAP1","EDN1","VEGFC","DYSF","SLAMF8","CCL5","LYN","IL12A","CSF1","IL6","GPR18","CAMK1D","CCL1","CXCL12","CCL4","FPR2","CCL2","CCL19","CCR6","CXCL8","RIPOR2","GAS6","CCL3","DAPK2","SLIT2"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_UV_B","pval":0.28816,"padj":0.84886,"ES":0.94297,"NES":1.23348,"nMoreExtreme":15662,"size":7,"leadingEdge":["CDKN1A","HYAL2"]} {"pathway":"GO_STRESS_INDUCED_PREMATURE_SENESCENCE","pval":0.28816,"padj":0.84886,"ES":0.94297,"NES":1.23348,"nMoreExtreme":15662,"size":7,"leadingEdge":["CDKN1A","MAPKAPK5"]} {"pathway":"GO_REGULATION_OF_TYPE_B_PANCREATIC_CELL_PROLIFERATION","pval":0.13868,"padj":0.73452,"ES":0.96567,"NES":1.23345,"nMoreExtreme":7749,"size":9,"leadingEdge":["NR4A3","PTPRN"]} {"pathway":"GO_PROTEOLYSIS","pval":0.00026,"padj":0.02582,"ES":0.67325,"NES":1.23334,"nMoreExtreme":25,"size":1375,"leadingEdge":["UBD","PSME2","AIM2","C4A","P2RX7","LRRK2","PSMB9","GSAP","C4B","FBXO6","SERPING1","LAMP3","TBX21","ERAP2","HGF","TNFSF10","ATP13A2","PSME1","CFB","LAP3","JAK2","PSMB10","FGL2","NUB1","AGT","IFI27","RIPK2","UBE2L6","PZP","C2","ECEL1","FAS","PSMB8","STAMBPL1","KLF4","BCL2L11","PML","RNF19B","C3","MEFV","ZC3H12A","CTSS","CYLD","CASP4","CARD17","CARD16","CASP7","CTSO","LACTB","C1S","C1RL","IFIH1","CNDP2","DTX3L","PMAIP1","COMP","C1R","POLB","GGT5","CHMP4C","LYN","PYHIN1","CHAC1","TRABD2A","MMP25","DNPEP","TANK","EPOP","OTUD1","CTRL","CTSL","TNFAIP3","EDEM1","RNF144B","BIRC3","CASP10","CTSZ","DESI1","ATXN7","HTRA4","TNF","PSMA4","PSMA2","HPN","SERPINB9","SPOPL","RBCK1","CUL1","TRIM72","UBE2A","DDX58","VCPIP1","PSEN2","CASP5","F3","STAT3","TRIM71","TRIM9","GCLC","SRC","TGFB1","A2M","KLK10","ROBO1","AKIRIN2","PSMA5","TRIM21","CTSC","RHBDF2","CAPNS2","UBE2Z","NFKBIA","IFI6","ISG15","SH3RF1","OTUD4","PLGRKT","PTGS2","ADAMTS20","SPPL2A","GAS6","PARL","CES1","USP18","PRELID1","TRIM25","CFLAR","GATA3","ERLIN1","BIRC7","CASP1","NKX3-1","NFE2L2","IL33","ADAMTS8","CCNA1","SERPINB1","SPINK1","HERPUD1","BBC3","ERAP1","IL1R2","SMAD3","HMSD","KLK1","BAK1","SCPEP1","NUPR1","KDM1B","RNF19A","NGF","TNFAIP8","UBR1"]} {"pathway":"GO_POSITIVE_T_CELL_SELECTION","pval":0.20785,"padj":0.79637,"ES":0.8983,"NES":1.2333,"nMoreExtreme":13298,"size":26,"leadingEdge":["CD74","IL12RB1","TBX21","SLAMF6","CYLD","IRF4","IL6","PTPRC","STAT3","PTPN2"]} {"pathway":"GO_METANEPHRIC_MESENCHYME_DEVELOPMENT","pval":0.07397,"padj":0.62748,"ES":0.9737,"NES":1.23302,"nMoreExtreme":4266,"size":12,"leadingEdge":["STAT1","SIX1"]} {"pathway":"GO_CELL_CELL_ADHESION_INVOLVED_IN_GASTRULATION","pval":0.08441,"padj":0.65161,"ES":0.97331,"NES":1.23251,"nMoreExtreme":4819,"size":11,"leadingEdge":["KLF4","IL1RN","WNK1"]} {"pathway":"GO_GLUTAMATE_METABOLIC_PROCESS","pval":0.11211,"padj":0.69864,"ES":0.94631,"NES":1.23244,"nMoreExtreme":6820,"size":18,"leadingEdge":["GGT5","GLUL","GCLC","GCLM"]} {"pathway":"GO_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE","pval":0.20448,"padj":0.79637,"ES":0.89214,"NES":1.23231,"nMoreExtreme":13147,"size":27,"leadingEdge":["IDO1","CD74","TBX21","NOD2","RSAD2","BCL6","IL6","CD86","GATA3","IL33","HLX","IFNL1"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_MINERALOCORTICOID_STIMULUS","pval":0.56599,"padj":0.93517,"ES":0.89579,"NES":1.23223,"nMoreExtreme":29948,"size":5,"leadingEdge":["EDN1","ATP2B1"]} {"pathway":"GO_REGULATION_OF_SUPEROXIDE_ANION_GENERATION","pval":0.11287,"padj":0.69864,"ES":0.94609,"NES":1.23214,"nMoreExtreme":6866,"size":18,"leadingEdge":["AGT","FPR2","TGFB1","TYROBP"]} {"pathway":"GO_ISG15_PROTEIN_CONJUGATION","pval":0.4332,"padj":0.90066,"ES":0.92141,"NES":1.23208,"nMoreExtreme":23249,"size":6,"leadingEdge":["UBE2L6","ISG15","HERC5"]} {"pathway":"GO_POSITIVE_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS","pval":0.07784,"padj":0.63581,"ES":0.96813,"NES":1.23204,"nMoreExtreme":4581,"size":14,"leadingEdge":["GSAP","LYN","PICALM"]} {"pathway":"GO_REGULATION_OF_MACROAUTOPHAGY","pval":0.07808,"padj":0.63581,"ES":0.71795,"NES":1.23179,"nMoreExtreme":6606,"size":161,"leadingEdge":["CALCOCO2","LRRK2","ATP13A2","OPTN","RIPK2","RALB","RUFY4","UVRAG","ATP6V1A","RRAGC","RRAGD","C9orf72","NPC1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY","pval":0.16229,"padj":0.76748,"ES":0.83169,"NES":1.23168,"nMoreExtreme":11128,"size":42,"leadingEdge":["P2RX7","IL12RB1","HLA-F","HLA-B","HLA-E","HLA-A","HLA-C","B2M","RSAD2","HLA-G","IL12A","IL6","PTPRC","GATA3"]} {"pathway":"GO_INTERLEUKIN_12_BIOSYNTHETIC_PROCESS","pval":0.29704,"padj":0.85691,"ES":0.94159,"NES":1.23167,"nMoreExtreme":16145,"size":7,"leadingEdge":["IRF1","LTB","TLR4"]} {"pathway":"GO_FATTY_ACID_HOMEOSTASIS","pval":0.07246,"padj":0.62163,"ES":0.97196,"NES":1.23164,"nMoreExtreme":4219,"size":13,"leadingEdge":["DGAT2","MLXIPL"]} {"pathway":"GO_CALCIUM_MEDIATED_SIGNALING_USING_INTRACELLULAR_CALCIUM_SOURCE","pval":0.11458,"padj":0.70006,"ES":0.94566,"NES":1.23159,"nMoreExtreme":6970,"size":18,"leadingEdge":["VCAM1","PTPRC","PRKACA"]} {"pathway":"GO_REGULATION_OF_SECRETION","pval":0.01144,"padj":0.27533,"ES":0.67768,"NES":1.23151,"nMoreExtreme":1115,"size":589,"leadingEdge":["AIM2","CD40","GBP1","CD74","P2RX7","SOCS1","CD274","LRRK2","CD38","NOD2","HLA-F","CEACAM1","CLEC9A","ATP13A2","HLA-E","BANK1","GRIN3A","HCAR2","JAK2","AGT","RIPK2","TLR8","SIDT2","CLEC6A","GSDMD","PML","SRI","TLR10","ZC3H12A","P2RX4","CARD17","SCIN","MCTP2","CARD16","NPR1","RSAD2","RALB","BTN2A2","EDN1","VEGFC","IFIH1","LILRA2","PTGER4","CCL5","LYN","OAS2","TIFAB","DTNBP1","GLUL","CADPS2","TNFRSF14","TNFAIP3","IL6","CLEC4E","FGF10","RSC1A1","TNF","RASGRP1","SMPD3","CCL1","CXCL12","PTAFR","DDX58","NR1H3","LILRB1","KMO","CACNA1I","P2RY12","TRIM9","SRC","TGFB1","SYT5","CCL19","UCP2","RHBDF2","P2RY2","GAS6","CCL3","CX3CL1","GATA3","CASP1","NKX3-1","SRCIN1","IL33","NADK","IL1R2","NAPA","SYT17"]} {"pathway":"GO_ISOPRENOID_BIOSYNTHETIC_PROCESS","pval":0.12693,"padj":0.72213,"ES":0.9391,"NES":1.23142,"nMoreExtreme":7795,"size":19,"leadingEdge":["CYP1A1","DHRS9","ALDH1A2"]} {"pathway":"GO_VASCULAR_ASSOCIATED_SMOOTH_MUSCLE_CELL_APOPTOTIC_PROCESS","pval":0.14686,"padj":0.75023,"ES":0.96393,"NES":1.23123,"nMoreExtreme":8206,"size":9,"leadingEdge":["SOD2","IGF1"]} {"pathway":"GO_NUCLEOSIDE_CATABOLIC_PROCESS","pval":0.21085,"padj":0.79831,"ES":0.89668,"NES":1.23108,"nMoreExtreme":13490,"size":26,"leadingEdge":["DPYS","TYMP","APOBEC3D","ENPP4","APOBEC3A","APOBEC3G","APOBEC3F","ADA2"]} {"pathway":"GO_ARF_PROTEIN_SIGNAL_TRANSDUCTION","pval":0.11605,"padj":0.70006,"ES":0.94524,"NES":1.23104,"nMoreExtreme":7060,"size":18,"leadingEdge":["IQSEC3","CYTH3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CHEMOKINE_MEDIATED_SIGNALING_PATHWAY","pval":0.43905,"padj":0.90126,"ES":0.92056,"NES":1.23095,"nMoreExtreme":23563,"size":6,"leadingEdge":["PADI2","CCL5","ROBO1","SLIT2"]} {"pathway":"GO_RESPONSE_TO_MURAMYL_DIPEPTIDE","pval":0.14302,"padj":0.74198,"ES":0.93236,"NES":1.23091,"nMoreExtreme":8840,"size":20,"leadingEdge":["NOD2","RIPK2","TNFAIP3","NFKBIA","IRF5","VIM"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MONONUCLEAR_CELL_MIGRATION","pval":0.43944,"padj":0.90126,"ES":0.92051,"NES":1.23088,"nMoreExtreme":23584,"size":6,"leadingEdge":["SLAMF8","PLCB1","SLIT2"]} {"pathway":"GO_CLEAVAGE_INVOLVED_IN_RRNA_PROCESSING","pval":0.15926,"padj":0.76421,"ES":0.92589,"NES":1.23087,"nMoreExtreme":9911,"size":21,"leadingEdge":["ERI1","EXOSC7"]} {"pathway":"GO_MATURATION_OF_5_8S_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA_","pval":0.15926,"padj":0.76421,"ES":0.92589,"NES":1.23087,"nMoreExtreme":9911,"size":21,"leadingEdge":["ERI1","EXOSC7"]} {"pathway":"GO_ROUNDABOUT_SIGNALING_PATHWAY","pval":0.43989,"padj":0.90126,"ES":0.92045,"NES":1.2308,"nMoreExtreme":23608,"size":6,"leadingEdge":["ROBO1","SLIT2","RHOA"]} {"pathway":"GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_CHEMOTAXIS","pval":0.43989,"padj":0.90126,"ES":0.92045,"NES":1.2308,"nMoreExtreme":23608,"size":6,"leadingEdge":["LPAR1","SLIT2","GSTP1"]} {"pathway":"GO_LUTEOLYSIS","pval":0.44028,"padj":0.90126,"ES":0.92039,"NES":1.23073,"nMoreExtreme":23629,"size":6,"leadingEdge":["SLIT2","HSPA5"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_1_BETA_SECRETION","pval":0.1496,"padj":0.75097,"ES":0.96336,"NES":1.23051,"nMoreExtreme":8359,"size":9,"leadingEdge":["PML","ZC3H12A","CARD17","CARD16","TNFAIP3"]} {"pathway":"GO_POST_EMBRYONIC_EYE_MORPHOGENESIS","pval":0.44121,"padj":0.90146,"ES":0.92022,"NES":1.2305,"nMoreExtreme":23679,"size":6,"leadingEdge":["BAK1","BAX"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS","pval":0.14787,"padj":0.7508,"ES":0.80351,"NES":1.23049,"nMoreExtreme":10499,"size":53,"leadingEdge":["IRF1","TLR8","IL27","CD80","TLR7","IRF4","TLR3","LTB","TNF","EBI3","CD86","PTPRC","PTAFR","STAT3","IL1A","TLR4","EREG","TICAM1","TLR1","PRKCQ"]} {"pathway":"GO_SERTOLI_CELL_DIFFERENTIATION","pval":0.09337,"padj":0.66429,"ES":0.95779,"NES":1.23043,"nMoreExtreme":5592,"size":16,"leadingEdge":["ICAM1","SOX8","ARID4A"]} {"pathway":"GO_EXCRETION","pval":0.17768,"padj":0.77529,"ES":0.85424,"NES":1.23037,"nMoreExtreme":11842,"size":35,"leadingEdge":["AGT","NPR1","EDN1","KCNMA1","AMN","ADORA2A","AQP9"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PROTEIN_KINASE_ACTIVITY_BY_REGULATION_OF_PROTEIN_PHOSPHORYLATION","pval":0.30365,"padj":0.86064,"ES":0.94056,"NES":1.23032,"nMoreExtreme":16504,"size":7,"leadingEdge":["DUSP10","ADAR","PPM1F"]} {"pathway":"GO_MICROTUBULE_ANCHORING","pval":0.19487,"padj":0.79001,"ES":0.91295,"NES":1.23028,"nMoreExtreme":12260,"size":23,"leadingEdge":["GCC2","CCDC68","CLASP1"]} {"pathway":"GO_MIRNA_LOADING_ONTO_RISC_INVOLVED_IN_GENE_SILENCING_BY_MIRNA","pval":0.30401,"padj":0.86102,"ES":0.9405,"NES":1.23025,"nMoreExtreme":16524,"size":7,"leadingEdge":["ADAR","AGO1"]} {"pathway":"GO_VASCULAR_WOUND_HEALING","pval":0.15099,"padj":0.7525,"ES":0.96314,"NES":1.23022,"nMoreExtreme":8437,"size":9,"leadingEdge":["TNFAIP3","ADIPOR2"]} {"pathway":"GO_POSITIVE_REGULATION_BY_HOST_OF_VIRAL_GENOME_REPLICATION","pval":0.44256,"padj":0.90221,"ES":0.92,"NES":1.2302,"nMoreExtreme":23751,"size":6,"leadingEdge":["STOM","YTHDC2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELL_DEATH","pval":0.01192,"padj":0.27955,"ES":0.67688,"NES":1.23014,"nMoreExtreme":1162,"size":591,"leadingEdge":["IDO1","UBD","CD40","P2RX7","CD274","LRRK2","TNFSF10","ATF3","CTLA4","HCAR2","JAK2","AGT","RIPK2","FAS","CAMK2D","BCL2L11","TGM2","AIFM2","PDCD1","PML","ZC3H12A","CYLD","RAPGEF2","IFIT2","CASP4","SCIN","IGF2R","PMAIP1","GADD45B","HLA-G","BCL6","CCL5","LYN","IL12A","LTA","NR4A3","C3orf38","SOD2","ARHGEF3","CASP10","CTSZ","IL6","TLR3","GADD45G","TNF","RBCK1","CAMK1D","FGD2","NCOA1","ASCL1","UNC5C","PTPRC","LILRB1","PSEN2","CASP5","F3","CCL2","KMO","PTPN2","MNDA","SRC","TGFB1","KCNMA1","ROBO1","CDKN1A","UCP2","TXNIP","CTSC","UBE2Z","SORT1","MCL1","LPAR1","PLEKHF1","PTGS2","CCL3","IRF5","PRELID1","CASP1","NKX3-1","BBC3","SMAD3","SLIT2","BAK1","NUPR1","SIK1","PNMA2","NGF","TNFAIP8","ARHGEF11","RAPSN","TLR4"]} {"pathway":"GO_REGULATION_OF_MACROPHAGE_APOPTOTIC_PROCESS","pval":0.21608,"padj":0.80167,"ES":0.95292,"NES":1.22994,"nMoreExtreme":11905,"size":8,"leadingEdge":["NOD2","IRF7","CCR5","MEF2C"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY","pval":0.10616,"padj":0.68361,"ES":0.95104,"NES":1.2299,"nMoreExtreme":6414,"size":17,"leadingEdge":["JAK2","PTPRC","PPP1R12A"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INTERLEUKIN_6_SECRETION","pval":0.19713,"padj":0.79165,"ES":0.91247,"NES":1.22964,"nMoreExtreme":12402,"size":23,"leadingEdge":["TLR8","IFIH1","LILRA2","TNF","DDX58","LILRA5"]} {"pathway":"GO_REGULATION_OF_RECEPTOR_RECYCLING","pval":0.14822,"padj":0.7508,"ES":0.93135,"NES":1.22958,"nMoreExtreme":9161,"size":20,"leadingEdge":["OPTN","AP1AR","VAMP3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS","pval":0.16448,"padj":0.76986,"ES":0.83024,"NES":1.22953,"nMoreExtreme":11278,"size":42,"leadingEdge":["LRRK2","HGF","NR4A3","SOD2","TXN","NFE2L2","MET","WNT1","MCTP1"]} {"pathway":"GO_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION","pval":0.08904,"padj":0.6584,"ES":0.72442,"NES":1.22948,"nMoreExtreme":7378,"size":140,"leadingEdge":["CD40","CEACAM1","AGT","KLF4","ZC3H12A","P2RX4","EDN1","VEGFC","MIR503","GLUL","ANXA3","STAT5A","TGFB1","SEMA4A","ADGRB1","PTGS2","GATA3","NFE2L2","MIR212","PDGFB","SLIT2"]} {"pathway":"GO_NEGATIVE_REGULATION_BY_HOST_OF_VIRAL_GENOME_REPLICATION","pval":0.30841,"padj":0.86348,"ES":0.93985,"NES":1.2294,"nMoreExtreme":16763,"size":7,"leadingEdge":["CCL8","ZC3H12A","CCNK"]} {"pathway":"GO_MAINTENANCE_OF_PROTEIN_LOCATION_IN_CELL","pval":0.13505,"padj":0.73185,"ES":0.78236,"NES":1.22935,"nMoreExtreme":9909,"size":65,"leadingEdge":["SPTBN4","PML","SCIN","TMSB10","TXN","CD4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ANOIKIS","pval":0.44697,"padj":0.90517,"ES":0.91933,"NES":1.2293,"nMoreExtreme":23988,"size":6,"leadingEdge":["SIK1","TLE5"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_T_CELL_MEDIATED_CYTOTOXICITY","pval":0.3092,"padj":0.86471,"ES":0.93972,"NES":1.22922,"nMoreExtreme":16806,"size":7,"leadingEdge":["CEACAM1","HLA-G","PTPRC","LILRB1","FCGR2B"]} {"pathway":"GO_VESICLE_TARGETING_TO_FROM_OR_WITHIN_GOLGI","pval":0.13135,"padj":0.72756,"ES":0.77521,"NES":1.22918,"nMoreExtreme":9753,"size":70,"leadingEdge":["CTSZ","CTSC","AP1AR","NAPA","TRAPPC6A"]} {"pathway":"GO_RELAXATION_OF_VASCULAR_SMOOTH_MUSCLE","pval":0.31051,"padj":0.86489,"ES":0.93955,"NES":1.229,"nMoreExtreme":16877,"size":7,"leadingEdge":["KCNMA1","GUCY1A1","RGS2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION","pval":0.15042,"padj":0.75116,"ES":0.93088,"NES":1.22896,"nMoreExtreme":9297,"size":20,"leadingEdge":["SOCS1","TBX21","ZC3H12A","JAK3","BCL6","RUNX1","HLX"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ACTIVATION_OF_JANUS_KINASE_ACTIVITY","pval":0.56666,"padj":0.93605,"ES":0.89333,"NES":1.22885,"nMoreExtreme":29983,"size":5,"leadingEdge":["AGT","CCL5","IL12B"]} {"pathway":"GO_CHLORIDE_TRANSPORT","pval":0.13355,"padj":0.72971,"ES":0.77897,"NES":1.22883,"nMoreExtreme":9850,"size":67,"leadingEdge":["APOL1","SLC12A3","ANO4","ABCB1","CLIC5","SLC12A7","SLC4A10","PTAFR","CLCN4","GABRR2","CLIC2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PHAGOCYTOSIS","pval":0.14605,"padj":0.74879,"ES":0.79867,"NES":1.22882,"nMoreExtreme":10426,"size":55,"leadingEdge":["IL15RA","C4A","C4B","IL15","C2","C3","CD300LF","STAP1","IL2RG","TNF","CD47","CAMK1D","PTPRC","CCL2","GAS6"]} {"pathway":"GO_CYTOKINE_SECRETION_INVOLVED_IN_IMMUNE_RESPONSE","pval":0.10996,"padj":0.69745,"ES":0.95003,"NES":1.22859,"nMoreExtreme":6644,"size":17,"leadingEdge":["NOD2","TNFRSF14","TNF","LILRB1","TNFRSF1B"]} {"pathway":"GO_LIPOPROTEIN_METABOLIC_PROCESS","pval":0.11018,"padj":0.69745,"ES":0.95002,"NES":1.22859,"nMoreExtreme":6657,"size":17,"leadingEdge":["APOL4","APOL1","APOL3","APOL2","APOL6","DGAT2","LIPG"]} {"pathway":"GO_REGULATION_OF_MUSCLE_SYSTEM_PROCESS","pval":0.076,"padj":0.63329,"ES":0.71152,"NES":1.22858,"nMoreExtreme":6513,"size":177,"leadingEdge":["PDE4B","SSTR2","AGT","KCNJ2","CAMK2D","KLF4","SRI","ZC3H12A","P2RX4","EDN1","ANK2","TIFAB","NR4A3","MYH7","RNF207","SLC8A1","PTAFR","PAK1","KCNMA1","GUCY1A1","PTGS2","CLIC2","SMAD3"]} {"pathway":"GO_MAST_CELL_MIGRATION","pval":0.11836,"padj":0.70259,"ES":0.96771,"NES":1.22854,"nMoreExtreme":6680,"size":10,"leadingEdge":["VEGFC","VEGFD"]} {"pathway":"GO_T_CELL_MEDIATED_CYTOTOXICITY","pval":0.16897,"padj":0.77295,"ES":0.8322,"NES":1.22794,"nMoreExtreme":11547,"size":41,"leadingEdge":["P2RX7","IL12RB1","HLA-F","CEACAM1","HLA-B","HLA-E","HLA-A","HLA-C","B2M","HLA-G","IL12A","PTPRC","LILRB1","CTSC"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING","pval":0.17514,"padj":0.77529,"ES":0.84513,"NES":1.22789,"nMoreExtreme":11781,"size":37,"leadingEdge":["OPTN","STAT1","ZC3H12A","TANK","TNFAIP3","RHOH","ZMYND11"]} {"pathway":"GO_ACTIVATION_OF_JNKK_ACTIVITY","pval":0.09982,"padj":0.66985,"ES":0.96949,"NES":1.22768,"nMoreExtreme":5699,"size":11,"leadingEdge":["RIPK2","NRK","MLKL"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_AUTOPHAGOSOME_ASSEMBLY","pval":0.09004,"padj":0.66071,"ES":0.96945,"NES":1.22764,"nMoreExtreme":5193,"size":12,"leadingEdge":["LRRK2","PHF23"]} {"pathway":"GO_GAMMA_DELTA_T_CELL_DIFFERENTIATION","pval":0.22675,"padj":0.81317,"ES":0.95112,"NES":1.22762,"nMoreExtreme":12493,"size":8,"leadingEdge":["EGR3","GPR18","PTPRC","NCKAP1L"]} {"pathway":"GO_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN","pval":0.45627,"padj":0.90517,"ES":0.91798,"NES":1.2275,"nMoreExtreme":24487,"size":6,"leadingEdge":["HLA-DOA","HLA-DOB","TAPBPL","HFE"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TISSUE_REMODELING","pval":0.09493,"padj":0.6659,"ES":0.96054,"NES":1.22723,"nMoreExtreme":5640,"size":15,"leadingEdge":["P2RX7","CD38","AGT","TNFAIP3","IL6"]} {"pathway":"GO_DENSE_CORE_GRANULE_TRANSPORT","pval":0.45774,"padj":0.90517,"ES":0.91775,"NES":1.2272,"nMoreExtreme":24566,"size":6,"leadingEdge":["MAP2","TRIM46","KIF1B"]} {"pathway":"GO_ATP_TRANSPORT","pval":0.22844,"padj":0.81508,"ES":0.95078,"NES":1.22718,"nMoreExtreme":12586,"size":8,"leadingEdge":["SLC25A25","SLC25A5"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY","pval":0.53111,"padj":0.92816,"ES":0.86172,"NES":1.22713,"nMoreExtreme":27641,"size":4,"leadingEdge":["TRIM72","NKX3-1","IGFBP5"]} {"pathway":"GO_PYRAMIDAL_NEURON_DIFFERENTIATION","pval":0.22914,"padj":0.81508,"ES":0.95067,"NES":1.22704,"nMoreExtreme":12625,"size":8,"leadingEdge":["SLC4A10","FGFR2"]} {"pathway":"GO_RESPONSE_TO_DOPAMINE","pval":0.09225,"padj":0.66428,"ES":0.96408,"NES":1.22689,"nMoreExtreme":5429,"size":14,"leadingEdge":["LRRK2","DNM2"]} {"pathway":"GO_REGULATION_OF_MUCUS_SECRETION","pval":0.32116,"padj":0.86901,"ES":0.93792,"NES":1.22687,"nMoreExtreme":17456,"size":7,"leadingEdge":["P2RY2","CYBA"]} {"pathway":"GO_POSITIVE_REGULATION_OF_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS","pval":0.1195,"padj":0.70363,"ES":0.75387,"NES":1.22684,"nMoreExtreme":9205,"size":89,"leadingEdge":["LRRK2","NUB1","RNF19B","PYHIN1","RNF144B","GCLC","NFE2L2","IL33","HERPUD1","RNF19A","PRICKLE1"]} {"pathway":"GO_CANONICAL_WNT_SIGNALING_PATHWAY","pval":0.05034,"padj":0.55323,"ES":0.69196,"NES":1.22681,"nMoreExtreme":4589,"size":279,"leadingEdge":["PSME2","LRRK2","PSMB9","KREMEN1","PSME1","DKK2","PSMB10","PSMB8","KLF4","CYLD","PTPRU","AMER1","FGF10","PSMA4","PSMA2","TCF7L1","NR4A2","SRC","PSMA5"]} {"pathway":"GO_TOLL_LIKE_RECEPTOR_7_SIGNALING_PATHWAY","pval":0.32168,"padj":0.86901,"ES":0.93786,"NES":1.2268,"nMoreExtreme":17484,"size":7,"leadingEdge":["RSAD2","TLR7","LILRA4","PIK3AP1","TREML4"]} {"pathway":"GO_PLASMA_MEMBRANE_TO_ENDOSOME_TRANSPORT","pval":0.32168,"padj":0.86901,"ES":0.93786,"NES":1.2268,"nMoreExtreme":17484,"size":7,"leadingEdge":["USP6NL","SORT1","SGSM3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_T_HELPER_1_CELL_DIFFERENTIATION","pval":0.46028,"padj":0.90517,"ES":0.91742,"NES":1.22675,"nMoreExtreme":24702,"size":6,"leadingEdge":["RIPK2","CD80","CCL19","HLX"]} {"pathway":"GO_REGULATION_OF_NEUROTRANSMITTER_LEVELS","pval":0.05556,"padj":0.56688,"ES":0.69494,"NES":1.22671,"nMoreExtreme":5011,"size":256,"leadingEdge":["P2RX7","LRRK2","GCH1","STX11","GRIN3A","KCNJ10","JAK2","AGT","ERC2","DPYS","ICAM1","KLF4","PRRT2","ZC3H12A","P2RX4","MCTP2","EDN1","SLC18A1","COLQ","NAAA","DTNBP1","GLUL","CADPS2","TNF","CD47","KMO","TRIM9","SYT5","SLC7A2","GPM6B","PTGS2","MIR212","NAPA","SMAD3","STX3","SYT17"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_COLLAGEN_BIOSYNTHETIC_PROCESS","pval":0.16445,"padj":0.76986,"ES":0.96039,"NES":1.22671,"nMoreExtreme":9189,"size":9,"leadingEdge":["CIITA","IL6"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_HYDROLASE_ACTIVITY","pval":0.042,"padj":0.51988,"ES":0.68678,"NES":1.22668,"nMoreExtreme":3903,"size":326,"leadingEdge":["C4A","LRRK2","C4B","SERPING1","LAMP3","AMOT","HGF","LMTK2","AGT","PZP","KLF4","C3","CARD17","CARD16","BIRC3","TNF","SERPINB9","RHOH","ANGPTL4","SRC","A2M","SNX16","UBE2Z","SORT1","MAP2","IFI6","SH3RF1","PTGS2","ELFN1","GAS6","CFLAR","BIRC7","SEMA4D","SERPINB1","SPINK1","HERPUD1","HMSD","SLIT2","MYOZ1","NGF","TNFAIP8"]} {"pathway":"GO_CYTOPLASMIC_SEQUESTERING_OF_NF_KAPPAB","pval":0.32243,"padj":0.86957,"ES":0.93775,"NES":1.22665,"nMoreExtreme":17525,"size":7,"leadingEdge":["NFKBIA","PSMD10"]} {"pathway":"GO_PROTEIN_TARGETING","pval":0.03142,"padj":0.45044,"ES":0.68172,"NES":1.22662,"nMoreExtreme":2976,"size":394,"leadingEdge":["LRRK2","RTP4","ACOT4","NCF1","NUCB1","GSTK1","ZDHHC19","ZDHHC18","ZDHHC11B","ATG3","KCNE1","PAK1","SNX16","AKAP12","PARL","STOM","NCOA4","ZDHHC23","GCC2","HAP1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING","pval":0.17188,"padj":0.77295,"ES":0.83404,"NES":1.22658,"nMoreExtreme":11715,"size":40,"leadingEdge":["BANK1","KLF4","BTN2A2","HLA-G","PKHD1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CHOLESTEROL_STORAGE","pval":0.23223,"padj":0.81508,"ES":0.95011,"NES":1.22631,"nMoreExtreme":12795,"size":8,"leadingEdge":["TTC39B","NR1H3","PPARD"]} {"pathway":"GO_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS","pval":0.17927,"padj":0.77529,"ES":0.8476,"NES":1.22628,"nMoreExtreme":12008,"size":36,"leadingEdge":["GSAP","LYN","PSEN2","HAP1"]} {"pathway":"GO_T_CELL_ACTIVATION_VIA_T_CELL_RECEPTOR_CONTACT_WITH_ANTIGEN_BOUND_TO_MHC_MOLECULE_ON_ANTIGEN_PRESENTING_CELL","pval":0.23261,"padj":0.81508,"ES":0.95005,"NES":1.22624,"nMoreExtreme":12816,"size":8,"leadingEdge":["HLA-DMB","ICAM1","ITGAL","LILRB1"]} {"pathway":"GO_REGULATION_OF_GAMMA_DELTA_T_CELL_ACTIVATION","pval":0.23261,"padj":0.81508,"ES":0.95005,"NES":1.22624,"nMoreExtreme":12816,"size":8,"leadingEdge":["NOD2","EGR3","PTPRC","LILRB1"]} {"pathway":"GO_OPSONIZATION","pval":0.46294,"padj":0.90517,"ES":0.91704,"NES":1.22624,"nMoreExtreme":24845,"size":6,"leadingEdge":["C4B","CD47"]} {"pathway":"GO_ETHER_METABOLIC_PROCESS","pval":0.16667,"padj":0.77278,"ES":0.95994,"NES":1.22613,"nMoreExtreme":9313,"size":9,"leadingEdge":["PLAAT3","EPHX1","TXN","TXN2"]} {"pathway":"GO_PROTEIN_O_LINKED_MANNOSYLATION","pval":0.11761,"padj":0.70191,"ES":0.94806,"NES":1.22605,"nMoreExtreme":7106,"size":17,"leadingEdge":["TMTC1","TMTC2","DPM1"]} {"pathway":"GO_REGULATION_OF_RECEPTOR_BIOSYNTHETIC_PROCESS","pval":0.11786,"padj":0.70259,"ES":0.94805,"NES":1.22604,"nMoreExtreme":7121,"size":17,"leadingEdge":["EDN1","NR1H3","HDAC6"]} {"pathway":"GO_AMPA_GLUTAMATE_RECEPTOR_CLUSTERING","pval":0.46426,"padj":0.90533,"ES":0.91685,"NES":1.22599,"nMoreExtreme":24916,"size":6,"leadingEdge":["SHISA7","SSH1"]} {"pathway":"GO_EPITHELIAL_FLUID_TRANSPORT","pval":0.32685,"padj":0.87108,"ES":0.93724,"NES":1.22598,"nMoreExtreme":17765,"size":7,"leadingEdge":["EDN1","EDNRB"]} {"pathway":"GO_GALACTOSE_METABOLIC_PROCESS","pval":0.46641,"padj":0.90732,"ES":0.91652,"NES":1.22554,"nMoreExtreme":25031,"size":6,"leadingEdge":["GALM","B4GALT1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_T_CELL_RECEPTOR_SIGNALING_PATHWAY","pval":0.11976,"padj":0.70444,"ES":0.94755,"NES":1.2254,"nMoreExtreme":7236,"size":17,"leadingEdge":["GBP1","CEACAM1","BTN2A2","LILRB4","PTPN2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_POLYUBIQUITINATION","pval":0.10806,"padj":0.69037,"ES":0.96761,"NES":1.2253,"nMoreExtreme":6169,"size":11,"leadingEdge":["NOD2","NMI","UBE2D1"]} {"pathway":"GO_RRNA_METHYLATION","pval":0.22471,"padj":0.81022,"ES":0.8977,"NES":1.22503,"nMoreExtreme":14314,"size":25,"leadingEdge":["BMT2","TFB1M"]} {"pathway":"GO_PURINE_CONTAINING_COMPOUND_METABOLIC_PROCESS","pval":0.09679,"padj":0.66591,"ES":0.72449,"NES":1.2249,"nMoreExtreme":7956,"size":133,"leadingEdge":["LRRK2","GIMAP7","ACOT4","SULT1C2","GTPBP1","DGAT2","CTNS","MYH7","SLC25A25","ATP6V1A","RHOQ","ACSM5","ACPP","AK4","NADK"]} {"pathway":"GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS","pval":0.22524,"padj":0.81135,"ES":0.89744,"NES":1.22468,"nMoreExtreme":14348,"size":25,"leadingEdge":["CD40","JAK2","HLA-G","IL6","CCL2","SORT1","BAD"]} {"pathway":"GO_OPTIC_NERVE_DEVELOPMENT","pval":0.33363,"padj":0.87575,"ES":0.93623,"NES":1.22466,"nMoreExtreme":18134,"size":7,"leadingEdge":["LPAR1","GLI3"]} {"pathway":"GO_COLLAGEN_METABOLIC_PROCESS","pval":0.11078,"padj":0.69745,"ES":0.95295,"NES":1.22422,"nMoreExtreme":6635,"size":16,"leadingEdge":["P2RX7","SMPD3","PLOD1"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_NUCLEUS","pval":0.06545,"padj":0.60364,"ES":0.69839,"NES":1.22415,"nMoreExtreme":5798,"size":224,"leadingEdge":["GBP2","AGT","PML","ZC3H12A","DTX3L","KPNA5","PYHIN1","PARP9","LILRB4","TXN","STAT3","SRC","TGFB1","TXNIP","PTGS2","SMAD3"]} {"pathway":"GO_COENZYME_BIOSYNTHETIC_PROCESS","pval":0.09753,"padj":0.66591,"ES":0.72402,"NES":1.22411,"nMoreExtreme":8017,"size":133,"leadingEdge":["IDO1","GCH1","IDO2","ACSL1","PARP10","PARP9","KYNU","ACSL5","ELOVL7","KMO","ACSS1","NAMPT","PTGS2","NADK","RFK"]} {"pathway":"GO_TRYPTOPHAN_METABOLIC_PROCESS","pval":0.24341,"padj":0.82387,"ES":0.94831,"NES":1.22399,"nMoreExtreme":13411,"size":8,"leadingEdge":["IDO1","IDO2","KYNU","KMO"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS","pval":0.33871,"padj":0.87818,"ES":0.93549,"NES":1.22369,"nMoreExtreme":18410,"size":7,"leadingEdge":["HLA-E","C3","FCER1G","BTK"]} {"pathway":"GO_REGULATION_OF_AMINO_ACID_TRANSMEMBRANE_TRANSPORT","pval":0.17706,"padj":0.77529,"ES":0.95801,"NES":1.22367,"nMoreExtreme":9894,"size":9,"leadingEdge":["AGT","PSEN1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PHAGOCYTOSIS","pval":0.12499,"padj":0.71645,"ES":0.9462,"NES":1.22365,"nMoreExtreme":7552,"size":17,"leadingEdge":["CD300LF","DYSF","CD47","ATG3","TGFB1","ATG5"]} {"pathway":"GO_POSTSYNAPTIC_SIGNAL_TRANSDUCTION","pval":0.24571,"padj":0.82387,"ES":0.94803,"NES":1.22363,"nMoreExtreme":13538,"size":8,"leadingEdge":["JAK2","STAT3","CRTC1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PLASMA_MEMBRANE_BOUNDED_CELL_PROJECTION_ASSEMBLY","pval":0.18674,"padj":0.78157,"ES":0.92038,"NES":1.22354,"nMoreExtreme":11621,"size":21,"leadingEdge":["STAP1","SLIT2","MAP4"]} {"pathway":"GO_REGULATION_OF_MYOTUBE_DIFFERENTIATION","pval":0.17736,"padj":0.77529,"ES":0.83487,"NES":1.22351,"nMoreExtreme":12046,"size":39,"leadingEdge":["CXCL10","CXCL9","BHLHE41","FLT3LG","TRIM72","ADGRB1","RIPOR2","CFLAR","CD53","SIK1","FLOT1","TBX1","HDAC4","EHD1"]} {"pathway":"GO_REGULATION_OF_MONOCYTE_DIFFERENTIATION","pval":0.11305,"padj":0.69864,"ES":0.95235,"NES":1.22344,"nMoreExtreme":6771,"size":16,"leadingEdge":["CD74","IRF7","CSF1","DCSTAMP"]} {"pathway":"GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_OSMOTIC_STRESS","pval":0.34007,"padj":0.87818,"ES":0.93528,"NES":1.22341,"nMoreExtreme":18484,"size":7,"leadingEdge":["PTGS2","BAD"]} {"pathway":"GO_DEATH_INDUCING_SIGNALING_COMPLEX_ASSEMBLY","pval":0.17778,"padj":0.77529,"ES":0.9578,"NES":1.2234,"nMoreExtreme":9934,"size":9,"leadingEdge":["TNF","CASP8"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TELOMERE_CAPPING","pval":0.24693,"padj":0.82387,"ES":0.9478,"NES":1.22334,"nMoreExtreme":13605,"size":8,"leadingEdge":["NBN","ERCC1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_AMPA_RECEPTOR_ACTIVITY","pval":0.47824,"padj":0.91418,"ES":0.91466,"NES":1.22306,"nMoreExtreme":25666,"size":6,"leadingEdge":["ARC","CACNG4"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_LIPOPOLYSACCHARIDE_MEDIATED_SIGNALING_PATHWAY","pval":0.1384,"padj":0.73356,"ES":0.96331,"NES":1.22295,"nMoreExtreme":7811,"size":10,"leadingEdge":["ACOD1","CARD16","LILRA2","TNFAIP3"]} {"pathway":"GO_CELL_MOTILITY_INVOLVED_IN_CEREBRAL_CORTEX_RADIAL_GLIA_GUIDED_MIGRATION","pval":0.24936,"padj":0.82387,"ES":0.94747,"NES":1.22291,"nMoreExtreme":13739,"size":8,"leadingEdge":["P2RY12","SYNE2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION","pval":0.15404,"padj":0.75438,"ES":0.79653,"NES":1.22275,"nMoreExtreme":10964,"size":54,"leadingEdge":["HLA-DPA1","IL12RB1","PDE4B","HLA-DPB1","RIPK2","TLR8","IL27","SLAMF6","IL12RB2","IL12A","TLR7","LTA","TLR3","TNF","EBI3","CD226","RASGRP1"]} {"pathway":"GO_REGULATION_OF_T_CELL_CYTOKINE_PRODUCTION","pval":0.22226,"padj":0.80586,"ES":0.89049,"NES":1.22258,"nMoreExtreme":14220,"size":26,"leadingEdge":["TBX21","HLA-F","B2M","RSAD2","IL6","GATA3"]} {"pathway":"GO_LYMPHOCYTE_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE","pval":0.09359,"padj":0.66439,"ES":0.71869,"NES":1.22246,"nMoreExtreme":7784,"size":144,"leadingEdge":["HLA-DMB","CD40","IL12RB1","TBX21","HLA-F","CEACAM1","RIPK2","IL27","ICAM1","TNFSF18","CD80","SLAMF6","ZC3H12A","JAK3","PTGER4","RELB","BCL6","PARP3","IRF4","IL6","CLEC4D","CLEC4E","NOTCH2","CD86","ITGAL","PTPRC","LILRB1","STAT3","NBN","TGFB1","SEMA4A","CCL19","CCR6","LIG4"]} {"pathway":"GO_MEMBRANE_REPOLARIZATION_DURING_ACTION_POTENTIAL","pval":0.20984,"padj":0.79773,"ES":0.91291,"NES":1.22221,"nMoreExtreme":13129,"size":22,"leadingEdge":["KCNJ2","KCNE5","RNF207","KCNE1","KCNE1B"]} {"pathway":"GO_ORGANONITROGEN_COMPOUND_CATABOLIC_PROCESS","pval":0.0018,"padj":0.09417,"ES":0.66764,"NES":1.222,"nMoreExtreme":178,"size":1087,"leadingEdge":["IDO1","UBD","PSME2","P2RX7","LRRK2","PSMB9","FBXO6","PDE4B","LAMP3","TBX21","ERAP2","CEACAM1","ATP13A2","PSME1","IDO2","PSMB10","NUB1","IFI27","DPYS","UBE2L6","IL4I1","PSMB8","TYMP","APOBEC3D","ENPP4","PML","RNF19B","APOBEC3A","APOBEC3G","CTSS","CYLD","CTSO","ENPP2","DTX3L","PMAIP1","SAT1","DYSF","SDC3","GGT5","CHMP4C","PYHIN1","CHAC1","GLUL","CTRL","CTSL","AMER1","KYNU","TNFAIP3","EDEM1","RNF144B","APOBEC3F","CTSZ","SDSL","TNF","PSMA4","PSMA2","SPOPL","RBCK1","CUL1","TRIM72","AZIN2","SMPD3","UBE2A","KMO","TRIM71","TRIM9","GCLC","TGFB1","HPD","PSMA5","ADA2","CTSC","GM2A","UBE2Z","ADGRB1","ISG15","USP18","TRIM25","ERLIN1","NFE2L2","IL33","HERPUD1","ERAP1","GLS","GNS","SMAD3"]} {"pathway":"GO_REGULATION_OF_NUCLEOTIDE_BINDING_OLIGOMERIZATION_DOMAIN_CONTAINING_2_SIGNALING_PATHWAY","pval":0.48414,"padj":0.91689,"ES":0.91376,"NES":1.22186,"nMoreExtreme":25983,"size":6,"leadingEdge":["TNFAIP3","TLR4"]} {"pathway":"GO_REGULATION_OF_HISTONE_DEACETYLATION","pval":0.2114,"padj":0.79831,"ES":0.91264,"NES":1.22186,"nMoreExtreme":13227,"size":22,"leadingEdge":["LRRK2","CAMK2D","BCL6","TGFB1","AKAP8L"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INTERFERON_BETA_PRODUCTION","pval":0.20763,"padj":0.79637,"ES":0.87451,"NES":1.22178,"nMoreExtreme":13473,"size":29,"leadingEdge":["IRF1","RIPK2","TLR8","IRF7","IFIH1","TLR7","TLR3","DDX58","IRF5","FLOT1","TLR4","TICAM1","POLR3D"]} {"pathway":"GO_REGULATION_OF_CELL_CELL_ADHESION_MEDIATED_BY_INTEGRIN","pval":0.25504,"padj":0.82758,"ES":0.94651,"NES":1.22167,"nMoreExtreme":14052,"size":8,"leadingEdge":["CCL5","PODXL","WNK1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR_VIA_NONHOMOLOGOUS_END_JOINING","pval":0.1087,"padj":0.69331,"ES":0.96471,"NES":1.22163,"nMoreExtreme":6269,"size":12,"leadingEdge":["DTX3L","PARP3","PARP9","RIF1"]} {"pathway":"GO_AMINE_CATABOLIC_PROCESS","pval":0.16184,"padj":0.76748,"ES":0.93156,"NES":1.22154,"nMoreExtreme":9939,"size":19,"leadingEdge":["IDO1","IDO2","SAT1","KYNU","KMO"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_APOPTOTIC_PROCESS","pval":0.10232,"padj":0.67367,"ES":0.96397,"NES":1.22153,"nMoreExtreme":5958,"size":13,"leadingEdge":["IL12A","SOD2","MAP2K4"]} {"pathway":"GO_MEMBRANE_DEPOLARIZATION","pval":0.14127,"padj":0.73885,"ES":0.7743,"NES":1.22145,"nMoreExtreme":10419,"size":67,"leadingEdge":["P2RX7","LRRK2","KCNJ2","CAMK2D","P2RX4","EDN1","ANK2","SLC8A1","SCN9A","CACNA1I","GCLC","SRC","IFI6"]} {"pathway":"GO_POSITIVE_REGULATION_OF_STEROL_TRANSPORT","pval":0.14664,"padj":0.75017,"ES":0.93782,"NES":1.22138,"nMoreExtreme":8921,"size":18,"leadingEdge":["LIPG","NR1H3","NFKBIA","ABCB4"]} {"pathway":"GO_L_ASCORBIC_ACID_METABOLIC_PROCESS","pval":0.25684,"padj":0.82758,"ES":0.94623,"NES":1.22131,"nMoreExtreme":14151,"size":8,"leadingEdge":["GCLC","SLC2A3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PROTEIN_HOMOOLIGOMERIZATION","pval":0.258,"padj":0.82758,"ES":0.94606,"NES":1.22109,"nMoreExtreme":14215,"size":8,"leadingEdge":["SRC","VPS35"]} {"pathway":"GO_DORSAL_VENTRAL_AXIS_SPECIFICATION","pval":0.25882,"padj":0.82758,"ES":0.94595,"NES":1.22095,"nMoreExtreme":14260,"size":8,"leadingEdge":["VAX2","SFRP1"]} {"pathway":"GO_MULTI_ORGANISM_MEMBRANE_FUSION","pval":0.35328,"padj":0.888,"ES":0.93337,"NES":1.22092,"nMoreExtreme":19202,"size":7,"leadingEdge":["CCR5","GAS6","CD4"]} {"pathway":"GO_NEURONAL_ION_CHANNEL_CLUSTERING","pval":0.12285,"padj":0.71181,"ES":0.96415,"NES":1.22091,"nMoreExtreme":7014,"size":11,"leadingEdge":["GLDN","SPTBN4","NRCAM","PICK1"]} {"pathway":"GO_REGULATION_OF_HYDROLASE_ACTIVITY","pval":0.00217,"padj":0.10317,"ES":0.6672,"NES":1.22089,"nMoreExtreme":215,"size":1039,"leadingEdge":["ATP1B2","PSME2","AIM2","CD40","C4A","LRRK2","ITK","PSMB9","C4B","SERPING1","LAMP3","CCL13","PLEK","AMOT","HGF","TNFSF10","ATP13A2","PSME1","TAGAP","LMTK2","JAK2","AGT","RIPK2","PZP","CCL7","FAS","PSMB8","CAMK2D","ICAM1","KLF4","BCL2L11","ARAP2","CCL15","VPS9D1","RSU1","PML","CCL8","C3","MEFV","RASGRF1","RAPGEF2","CASP4","CARD17","CARD16","USP6NL","PMAIP1","S100A10","BCL6","CCL18","CCL5","LYN","OAS2","TANK","OAS3","PLSCR1","DENND1B","BIRC3","CASP10","ARHGAP25","RASGEF1B","FGF10","TNF","FLT1","SERPINB9","RASGRP1","CCL1","FGD2","PTPRC","RHOH","PTAFR","CCL4","NR1H3","CASP5","F3","CCL2","STAT3","P2RY12","ANGPTL4","SRC","ARHGAP17","TBC1D2B","A2M","CDC42EP2","ROBO1","CCL19","STMN3","SNX16","AKIRIN2","PDGFRA","GM2A","UBE2Z","SORT1","MAP2","IFI6","SH3RF1","LPAR1","PTGS2","ELFN1","GAS6","CCL3","RGS1","CX3CL1","PRELID1","CFLAR","RGS9","BIRC7","CASP1","NKX3-1","PPARGC1B","SEMA4D","SERPINB1","SPINK1","HERPUD1","BBC3","PLCB1","ELMOD1","NAPA","SMAD3","FGD6","LMF1","HMSD","SLIT2","BAK1","OASL","MYOZ1","NGF","TNFAIP8","EDNRA","PPP1R16B","ARHGEF11"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_TOXIC_SUBSTANCE","pval":0.0796,"padj":0.63757,"ES":0.70454,"NES":1.22086,"nMoreExtreme":6873,"size":186,"leadingEdge":["IL18BP","LRRK2","GCH1","HGF","CCL7","XRN1","KLF4","ZC3H12A","GSTK1","NR4A3","SOD2","TNFAIP3","IL6","TXN","TNF","SMPD3","SRC","PRDX1","PTGS2","NFE2L2","CLIC2","PDGFB","SLC31A1","IL18RAP","KCNMB1","ZNF277","MET"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_FIBROBLAST_APOPTOTIC_PROCESS","pval":0.35356,"padj":0.888,"ES":0.93331,"NES":1.22084,"nMoreExtreme":19217,"size":7,"leadingEdge":["GAS6","CHD8"]} {"pathway":"GO_INTERLEUKIN_8_PRODUCTION","pval":0.15008,"padj":0.75097,"ES":0.78623,"NES":1.2208,"nMoreExtreme":10840,"size":59,"leadingEdge":["NOD2","TLR8","KLF4","LILRA2","TLR7","MYD88","TLR3","TNF","PTPRC","CHI3L1","DDX58","TLR4","CD244"]} {"pathway":"GO_AUTOPHAGOSOME_ORGANIZATION","pval":0.1236,"padj":0.71278,"ES":0.74835,"NES":1.22068,"nMoreExtreme":9555,"size":91,"leadingEdge":["LRRK2","ATP13A2","RALB","RUFY4","ATG3","STX17","C9orf72"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELL_FATE_COMMITMENT","pval":0.4908,"padj":0.91818,"ES":0.91281,"NES":1.22059,"nMoreExtreme":26340,"size":6,"leadingEdge":["IL12RB1","IL12B"]} {"pathway":"GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL","pval":0.21423,"padj":0.7999,"ES":0.87829,"NES":1.22055,"nMoreExtreme":13838,"size":28,"leadingEdge":["ANK2","KCNE5","RNF207","KCNE1","KCNE1B","DSG2"]} {"pathway":"GO_SIGNAL_TRANSDUCTION_BY_PROTEIN_PHOSPHORYLATION","pval":0.00745,"padj":0.22609,"ES":0.66864,"NES":1.22045,"nMoreExtreme":736,"size":769,"leadingEdge":["IL31RA","PSME2","CD40","GBP1","CD74","P2RX7","LRRK2","PSMB9","NOD2","CEACAM1","CCL13","HGF","PSME1","IL3RA","BANK1","ATF3","JAK2","PSMB10","AGT","RIPK2","CCL7","FAS","PSMB8","SPTBN4","ICAM1","KLF4","CCL15","FLT3LG","CSF2RB","CCL8","SCIMP","RASGRF1","ZC3H12A","JAK3","CYLD","RAPGEF2","BTN2A2","EDN1","SLAMF1","NCF1","NRK","MIR503","IL1RN","GADD45B","GLIPR2","PTGER4","CCL18","CCL5","LYN","DTNBP1","VRK2","GAREM1","NRG4","IL6","TLR3","FGF10","IL2RG","GADD45G","SEMA7A","NOTCH2","TNF","PSMA4","FLT1","PSMA2","CUL1","DUSP10","RASGRP1","CCR5","CCL1","FGD2","PTPRC","CHI3L1","CCL4","FPR2","CCL2","PTPN2","PAK1","NRG2","SRC","TGFB1","ROBO1","IL2RA","CCL19","PSMA5","PRDX1","PDGFRA","DUSP5","PTPN1","ACTN2","PKHD1","SH3RF1","LPAR1","GAS6","CCL3","CX3CL1","CFLAR"]} {"pathway":"GO_ALPHA_AMINO_ACID_METABOLIC_PROCESS","pval":0.10135,"padj":0.67298,"ES":0.72171,"NES":1.22021,"nMoreExtreme":8331,"size":133,"leadingEdge":["IDO1","IDO2","GGT5","GLUL","KYNU","SDSL","KMO","GCLC","ASNS","GLS","SEPHS2","ASS1","MTHFR","CBSL","SDS"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_VASCULAR_SMOOTH_MUSCLE_CELL_PROLIFERATION","pval":0.13811,"padj":0.73306,"ES":0.94305,"NES":1.21958,"nMoreExtreme":8345,"size":17,"leadingEdge":["MIR503","SOD2","CDKN1A","MEF2C"]} {"pathway":"GO_ESTABLISHMENT_OR_MAINTENANCE_OF_ACTIN_CYTOSKELETON_POLARITY","pval":0.11598,"padj":0.70006,"ES":0.96308,"NES":1.21957,"nMoreExtreme":6689,"size":12,"leadingEdge":["RND1","RHOA"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_BONE_REMODELING","pval":0.15199,"padj":0.75292,"ES":0.9605,"NES":1.21938,"nMoreExtreme":8578,"size":10,"leadingEdge":["P2RX7","CD38","TNFAIP3","IL6"]} {"pathway":"GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_ENDOGENOUS_PEPTIDE_ANTIGEN","pval":0.10939,"padj":0.69587,"ES":0.96226,"NES":1.21936,"nMoreExtreme":6370,"size":13,"leadingEdge":["TAP2","TAP1","ERAP2","HLA-F","HLA-B","HLA-E","HLA-A","HLA-C","TAPBP","B2M","HLA-G"]} {"pathway":"GO_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY","pval":0.17215,"padj":0.77295,"ES":0.81424,"NES":1.21907,"nMoreExtreme":11951,"size":45,"leadingEdge":["SLAMF7","LAG3","HLA-F","CEACAM1","HLA-E","SLAMF6","HLA-G","IL12A","SERPINB9","CD226","RASGRP1","LILRB1","PRDX1"]} {"pathway":"GO_POTASSIUM_ION_HOMEOSTASIS","pval":0.13986,"padj":0.73655,"ES":0.94264,"NES":1.21904,"nMoreExtreme":8451,"size":17,"leadingEdge":["ATP1B2","KCNJ10","SLC12A3","KCNJ2","SLC12A7","KCNMA1"]} {"pathway":"GO_REGULATION_OF_ACTIVATION_OF_JANUS_KINASE_ACTIVITY","pval":0.36338,"padj":0.89036,"ES":0.93193,"NES":1.21904,"nMoreExtreme":19751,"size":7,"leadingEdge":["SOCS1","AGT","CCL5"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NATURAL_KILLER_CELL_PROLIFERATION","pval":0.36338,"padj":0.89036,"ES":0.93191,"NES":1.21901,"nMoreExtreme":19751,"size":7,"leadingEdge":["IL15","HLA-E","FLT3LG"]} {"pathway":"GO_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS","pval":0.01558,"padj":0.3215,"ES":0.67017,"NES":1.21873,"nMoreExtreme":1522,"size":606,"leadingEdge":["GBP5","IDO1","AIM2","CD74","LRRK2","IL12RB1","IL15","SERPING1","CXCL10","NOD2","CEACAM1","PLEK","HGF","KREMEN1","HLA-E","ACOD1","PADI2","OPTN","STAT1","GRIN3A","JAK2","SUCNR1","AGT","RIPK2","CCL7","IL27","KLF4","SCARF1","TGM2","ENPP4","TSPAN32","C3","APOBEC3G","MEFV","TLR10","ZC3H12A","CYLD","P2RX4","STAP1","CARD16","EDN1","VEGFC","DTX3L","LILRA2","SBNO2","DDX60","DYSF","SLAMF8","PTGER4","BCL6","CCL18","CCL5","LYN","IL12A","TNFAIP6","TLR7","CSF1","LTA","PARP9","TNFAIP3","BIRC3","MYD88","APOBEC3F","IL6","TLR3","FGF10","SEMA7A","TNF","DUSP10","GPR18","CD47","PIK3AP1","CAMK1D","CCL1","CXCL12","CYP27B1","PTPRC","DDX58","CCL4","NR1H3","LILRB1","FPR2","F3","SOCS3","CCL2","GUCA1A","P2RY12","PTPN2","DHX58","TGFB1","SEMA4A","ROBO1","IL2RA","CCL19","CGAS","CCR6","CXCL8","CDKN1A","GP1BA","PDGFRA","SLC7A2","NFKBIA","RGMA","LPAR1","PTGS2","RIPOR2","GAS6","CCL3","CX3CL1","USP18","GATA3","NFE2L2","IL33","SEMA4D","DAPK2","IL1R2","PDGFB","SMAD3","STX3"]} {"pathway":"GO_CYSTEINE_BIOSYNTHETIC_PROCESS","pval":0.50102,"padj":0.91978,"ES":0.9114,"NES":1.21871,"nMoreExtreme":26889,"size":6,"leadingEdge":["GGT5","CBSL"]} {"pathway":"GO_TOXIN_BIOSYNTHETIC_PROCESS","pval":0.50142,"padj":0.91978,"ES":0.91135,"NES":1.21863,"nMoreExtreme":26910,"size":6,"leadingEdge":["CBSL","CTH"]} {"pathway":"GO_ACTIVATION_INDUCED_CELL_DEATH_OF_T_CELLS","pval":0.26996,"padj":0.83739,"ES":0.94409,"NES":1.21856,"nMoreExtreme":14874,"size":8,"leadingEdge":["IL2RA","DNAJA3"]} {"pathway":"GO_EXTRACELLULAR_VESICLE_BIOGENESIS","pval":0.20669,"padj":0.79637,"ES":0.91655,"NES":1.21845,"nMoreExtreme":12863,"size":21,"leadingEdge":["ATP13A2","SMPD3","RAB27A"]} {"pathway":"GO_ANGIOGENESIS_INVOLVED_IN_WOUND_HEALING","pval":0.17453,"padj":0.77529,"ES":0.92892,"NES":1.21806,"nMoreExtreme":10718,"size":19,"leadingEdge":["TNFAIP3","CX3CL1","ADIPOR2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SINGLE_STRANDED_VIRAL_RNA_REPLICATION_VIA_DOUBLE_STRANDED_DNA_INTERMEDIATE","pval":0.11346,"padj":0.69895,"ES":0.96122,"NES":1.21804,"nMoreExtreme":6607,"size":13,"leadingEdge":["APOBEC3D","APOBEC3G","APOBEC3F"]} {"pathway":"GO_MESENCHYMAL_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT","pval":0.5044,"padj":0.91988,"ES":0.9109,"NES":1.21803,"nMoreExtreme":27070,"size":6,"leadingEdge":["STAT1","AMER1","TCF21"]} {"pathway":"GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE","pval":0.05292,"padj":0.55951,"ES":0.68433,"NES":1.2178,"nMoreExtreme":4870,"size":302,"leadingEdge":["VAMP5","OPTN","RTP4","BCL2L11","NCF1","PMAIP1","COLQ","ZDHHC19","ZDHHC18","ZDHHC11B","ATG3","KCNE1","PAK1","AMN","BBC3","RILPL1","STX3","STOM","RAPSN","ZDHHC23","NPC1"]} {"pathway":"GO_REGULATION_OF_VENTRICULAR_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL","pval":0.12241,"padj":0.71068,"ES":0.96162,"NES":1.21772,"nMoreExtreme":7060,"size":12,"leadingEdge":["RNF207","DSG2"]} {"pathway":"GO_L_PHENYLALANINE_CATABOLIC_PROCESS","pval":0.27433,"padj":0.83769,"ES":0.94342,"NES":1.21768,"nMoreExtreme":15115,"size":8,"leadingEdge":["IL4I1","HPD","GSTZ1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_DENDRITIC_CELL_CYTOKINE_PRODUCTION","pval":0.37131,"padj":0.89036,"ES":0.93088,"NES":1.21767,"nMoreExtreme":20182,"size":7,"leadingEdge":["NOD2","DDX58","TICAM1"]} {"pathway":"GO_NUCLEAR_TRANSPORT","pval":0.0517,"padj":0.55686,"ES":0.68301,"NES":1.21763,"nMoreExtreme":4780,"size":312,"leadingEdge":["EGR2","AGT","IFI27","PML","ZC3H12A","KPNA5","TXN","STAT3","TGFB1","TXNIP","PTGS2","GAS6","SMAD3","XPO6"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TRANSMEMBRANE_TRANSPORT","pval":0.09728,"padj":0.66591,"ES":0.71424,"NES":1.21758,"nMoreExtreme":8128,"size":148,"leadingEdge":["ATP1B2","P2RX7","CXCL11","CXCL10","CXCL9","AGT","KCNJ2","SRI","C3","ABCB1","CTSS","ANK2","NR4A3","KCNE5","RNF207","STAC3","AZIN2","PTAFR","KCNE1","RHOQ","ACTN2","CX3CL1","RGS9","NFE2L2","GLRX","S100A1","ARC","KCNMB1"]} {"pathway":"GO_REGULATION_OF_VIRAL_INDUCED_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY","pval":0.17687,"padj":0.77529,"ES":0.9284,"NES":1.21739,"nMoreExtreme":10862,"size":19,"leadingEdge":["DDX60","BIRC3","DHX58","TSPAN6"]} {"pathway":"GO_DNA_DEAMINATION","pval":0.1366,"padj":0.73299,"ES":0.96128,"NES":1.21728,"nMoreExtreme":7799,"size":11,"leadingEdge":["APOBEC3D","APOBEC3A","APOBEC3G","APOBEC3F","EXOSC5"]} {"pathway":"GO_REGULATION_OF_GOLGI_ORGANIZATION","pval":0.12431,"padj":0.71407,"ES":0.95273,"NES":1.21725,"nMoreExtreme":7386,"size":15,"leadingEdge":["USP6NL","PDE4DIP","EHD3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SPHINGOLIPID_BIOSYNTHETIC_PROCESS","pval":0.20518,"padj":0.79637,"ES":0.95297,"NES":1.21723,"nMoreExtreme":11465,"size":9,"leadingEdge":["TNF","SMPD3","NSMAF"]} {"pathway":"GO_INTERACTION_WITH_SYMBIONT","pval":0.14847,"padj":0.7508,"ES":0.77604,"NES":1.21707,"nMoreExtreme":10872,"size":64,"leadingEdge":["IFI27","CCL8","ZC3H12A","CCL5","HPN","CCL4","CCL3","STOM","GTF2B"]} {"pathway":"GO_TOLERANCE_INDUCTION","pval":0.21229,"padj":0.79938,"ES":0.91548,"NES":1.21703,"nMoreExtreme":13211,"size":21,"leadingEdge":["IDO1","CD274","HLA-E","ACOD1","PDCD1","HLA-G","LYN","TNFAIP3","TGFB1","ICOS","IL2RA"]} {"pathway":"GO_SCHWANN_CELL_PROLIFERATION","pval":0.27807,"padj":0.84109,"ES":0.94291,"NES":1.21702,"nMoreExtreme":15321,"size":8,"leadingEdge":["ASCL2","RNF10"]} {"pathway":"GO_MEMBRANE_PROTEIN_INTRACELLULAR_DOMAIN_PROTEOLYSIS","pval":0.16216,"padj":0.76748,"ES":0.93445,"NES":1.21699,"nMoreExtreme":9865,"size":18,"leadingEdge":["PSEN2","TGFB1","SPPL2A","SPPL2B"]} {"pathway":"GO_REGULATION_OF_NEURON_PROJECTION_ARBORIZATION","pval":0.20637,"padj":0.79637,"ES":0.95274,"NES":1.21694,"nMoreExtreme":11532,"size":9,"leadingEdge":["MOV10","DVL2"]} {"pathway":"GO_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING","pval":0.18335,"padj":0.77986,"ES":0.82748,"NES":1.21693,"nMoreExtreme":12497,"size":40,"leadingEdge":["KLF4","SRI","TGFB1","FOXC1","GATA3","GTF2B"]} {"pathway":"GO_NATURAL_KILLER_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE","pval":0.11698,"padj":0.70159,"ES":0.96026,"NES":1.21681,"nMoreExtreme":6812,"size":13,"leadingEdge":["HLA-F","CD244"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_OXIDATIVE_STRESS","pval":0.06382,"padj":0.59614,"ES":0.68926,"NES":1.21669,"nMoreExtreme":5756,"size":256,"leadingEdge":["IL18BP","LRRK2","GCH1","HGF","ATP13A2","JAK2","KLF4","PML","ZC3H12A","NCF1","VRK2","NR4A3","SOD2","TNFAIP3","IL6","TXN","RBM11","TNF","SMPD3","NR4A2","SRC","PRDX1","PDGFRA","MCL1","NME8","NCF2","GUCY1B1","CFLAR","NFE2L2","PPARGC1B"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELL_KILLING","pval":0.14753,"padj":0.7508,"ES":0.94077,"NES":1.21662,"nMoreExtreme":8914,"size":17,"leadingEdge":["HLA-F","CEACAM1","HLA-E","HLA-G","SERPINB9","PTPRC","LILRB1","CLEC12B"]} {"pathway":"GO_AZOLE_TRANSPORT","pval":0.1357,"padj":0.73227,"ES":0.94697,"NES":1.21654,"nMoreExtreme":8128,"size":16,"leadingEdge":["EDN1","LYN","BTK"]} {"pathway":"GO_PHOSPHOLIPID_CATABOLIC_PROCESS","pval":0.21446,"padj":0.7999,"ES":0.87058,"NES":1.21629,"nMoreExtreme":13916,"size":29,"leadingEdge":["ENPP2","PLA2G4C","PLA2G4A","SMPD3","LIPG","GDE1"]} {"pathway":"GO_REGULATION_OF_T_HELPER_2_CELL_CYTOKINE_PRODUCTION","pval":0.37852,"padj":0.89036,"ES":0.92983,"NES":1.21629,"nMoreExtreme":20574,"size":7,"leadingEdge":["TBX21","RSAD2","IL6","GATA3"]} {"pathway":"GO_REGULATION_OF_CHEMOKINE_C_X_C_MOTIF_LIGAND_2_PRODUCTION","pval":0.16483,"padj":0.76986,"ES":0.95797,"NES":1.21617,"nMoreExtreme":9303,"size":10,"leadingEdge":["CD74","MCOLN2","KLF4","TNF"]} {"pathway":"GO_REGULATION_OF_HISTONE_H3_K27_METHYLATION","pval":0.37976,"padj":0.89036,"ES":0.92966,"NES":1.21607,"nMoreExtreme":20641,"size":7,"leadingEdge":["GATA3","EED"]} {"pathway":"GO_LUNG_ALVEOLUS_DEVELOPMENT","pval":0.19398,"padj":0.79001,"ES":0.84429,"NES":1.21604,"nMoreExtreme":12928,"size":35,"leadingEdge":["FGF10","SMPD3","TNS3","FLT4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELL_ADHESION_MEDIATED_BY_INTEGRIN","pval":0.13714,"padj":0.73301,"ES":0.94654,"NES":1.21599,"nMoreExtreme":8214,"size":16,"leadingEdge":["CCL5","P2RY12","PODXL","TGFB2"]} {"pathway":"GO_ANION_HOMEOSTASIS","pval":0.19158,"padj":0.79001,"ES":0.8404,"NES":1.21585,"nMoreExtreme":12833,"size":36,"leadingEdge":["SLC12A3","DGAT2","SLC12A7","LIPG","CKB","MLXIPL"]} {"pathway":"GO_COFACTOR_METABOLIC_PROCESS","pval":0.04575,"padj":0.53742,"ES":0.67867,"NES":1.21582,"nMoreExtreme":4288,"size":351,"leadingEdge":["IDO1","GCH1","CD38","IDO2","ACSL1","CYP1A1","CBR3","PARP10","ACOT4","ALAS1","MTHFD2","CNDP2","GSTK1","DGAT2","CTNS","GGT5","CHAC1","PARP9","KYNU","TCN2","ACSL5","ELOVL7","KMO","STAT3","GCLC","ACSS1","PRDX1","NAMPT","MMAA","PTGS2","AMN","ACSM5","NFE2L2","NADK","SPTA1","RFK"]} {"pathway":"GO_CERAMIDE_CATABOLIC_PROCESS","pval":0.15014,"padj":0.75097,"ES":0.94013,"NES":1.2158,"nMoreExtreme":9072,"size":17,"leadingEdge":["GM2A","HEXB"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INTERFERON_ALPHA_PRODUCTION","pval":0.19977,"padj":0.79183,"ES":0.9209,"NES":1.21578,"nMoreExtreme":12348,"size":20,"leadingEdge":["STAT1","RIPK2","TLR8","IRF7","IFIH1","TLR7","TLR3","DDX58","IRF5","TLR4"]} {"pathway":"GO_MYOTUBE_DIFFERENTIATION","pval":0.14469,"padj":0.74547,"ES":0.76398,"NES":1.21566,"nMoreExtreme":10797,"size":72,"leadingEdge":["CXCL10","CXCL9","MYOF","BHLHE41","FLT3LG","STAC3","PLEKHO1","TRIM72","SORT1","ADGRB1","RIPOR2","CFLAR","CD53","SIK1","FLOT1","TBX1","WNT1","HDAC4","SIX1","EHD1"]} {"pathway":"GO_B_CELL_ACTIVATION","pval":0.08348,"padj":0.64848,"ES":0.70048,"NES":1.21564,"nMoreExtreme":7231,"size":190,"leadingEdge":["CD40","CD74","CD38","TBX21","NOD2","BANK1","CTLA4","TNFSF13B","VCAM1","JAK3","CYLD","SLAMF8","BCL6","LYN","PARP3","IL7","TNFAIP3","IL6","NOTCH2","PTPRC","TPD52","KLF6","NBN","PTPN2","MNDA","TGFB1","CCR6","LIG4"]} {"pathway":"GO_LAMELLIPODIUM_MORPHOGENESIS","pval":0.13882,"padj":0.73467,"ES":0.94615,"NES":1.21548,"nMoreExtreme":8315,"size":16,"leadingEdge":["ENPP2","PLEKHO1","SRC","CD44"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SECRETION","pval":0.05314,"padj":0.56014,"ES":0.68172,"NES":1.21547,"nMoreExtreme":4915,"size":313,"leadingEdge":["AIM2","P2RX7","CD274","LRRK2","CD38","NOD2","HLA-F","CLEC9A","ATP13A2","HLA-E","HCAR2","JAK2","AGT","RIPK2","TLR8","CLEC6A","GSDMD","SRI","P2RX4","SCIN","NPR1","EDN1","VEGFC","IFIH1","LILRA2","PTGER4","DTNBP1","GLUL","CADPS2","TNFRSF14","IL6","CLEC4E","TNF","RASGRP1","SMPD3","CCL1","CXCL12","PTAFR","DDX58","KMO","CACNA1I","SRC","TGFB1","CCL19","P2RY2","CCL3","GATA3","CASP1","NKX3-1","IL33","NADK","ILDR1","IL1A","FCER1G","LILRA5"]} {"pathway":"GO_POSITIVE_REGULATION_OF_HISTONE_DEACETYLATION","pval":0.13901,"padj":0.73467,"ES":0.94609,"NES":1.21541,"nMoreExtreme":8326,"size":16,"leadingEdge":["LRRK2","BCL6","TGFB1","AKAP8L"]} {"pathway":"GO_REGULATION_OF_PROTEIN_HOMOOLIGOMERIZATION","pval":0.13901,"padj":0.73467,"ES":0.94609,"NES":1.21541,"nMoreExtreme":8326,"size":16,"leadingEdge":["BCL2L11","SRC","BID"]} {"pathway":"GO_RENAL_SODIUM_EXCRETION","pval":0.12208,"padj":0.71013,"ES":0.95911,"NES":1.21536,"nMoreExtreme":7109,"size":13,"leadingEdge":["AGT","NPR1","EDN1","ADORA2A"]} {"pathway":"GO_MUSCLE_CELL_CELLULAR_HOMEOSTASIS","pval":0.13963,"padj":0.73582,"ES":0.94598,"NES":1.21527,"nMoreExtreme":8363,"size":16,"leadingEdge":["TGFB1","LAMP2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INTERFERON_GAMMA_BIOSYNTHETIC_PROCESS","pval":0.16804,"padj":0.77295,"ES":0.95724,"NES":1.21525,"nMoreExtreme":9484,"size":10,"leadingEdge":["TLR8","IL27","TLR7","TLR3","EBI3"]} {"pathway":"GO_MESENCHYMAL_STEM_CELL_DIFFERENTIATION","pval":0.28696,"padj":0.84886,"ES":0.94145,"NES":1.21515,"nMoreExtreme":15811,"size":8,"leadingEdge":["PDGFRA","REST"]} {"pathway":"GO_GLUTAMINE_METABOLIC_PROCESS","pval":0.16934,"padj":0.77295,"ES":0.93299,"NES":1.21508,"nMoreExtreme":10302,"size":18,"leadingEdge":["GLUL","ASNS","CPS1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE","pval":0.21507,"padj":0.80139,"ES":0.95123,"NES":1.21501,"nMoreExtreme":12018,"size":9,"leadingEdge":["ACOD1","C3","LTA","TNF","PTPRC","FCGR2B"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION","pval":0.22079,"padj":0.80556,"ES":0.91392,"NES":1.21495,"nMoreExtreme":13740,"size":21,"leadingEdge":["LILRB3","TLR3","LILRB4","LILRB1","CCL3","TLR4"]} {"pathway":"GO_CD4_POSITIVE_ALPHA_BETA_T_CELL_PROLIFERATION","pval":0.38623,"padj":0.89273,"ES":0.92865,"NES":1.21475,"nMoreExtreme":20993,"size":7,"leadingEdge":["CD274","ARG2"]} {"pathway":"GO_OTIC_VESICLE_FORMATION","pval":0.52135,"padj":0.9256,"ES":0.90837,"NES":1.21465,"nMoreExtreme":27980,"size":6,"leadingEdge":["FGF10","PROX1","FGFR2"]} {"pathway":"GO_LYMPHATIC_ENDOTHELIAL_CELL_DIFFERENTIATION","pval":0.52167,"padj":0.9256,"ES":0.90831,"NES":1.21458,"nMoreExtreme":27997,"size":6,"leadingEdge":["PROX1","ACVR2B"]} {"pathway":"GO_REGULATION_OF_BILE_ACID_METABOLIC_PROCESS","pval":0.52167,"padj":0.9256,"ES":0.90831,"NES":1.21458,"nMoreExtreme":27997,"size":6,"leadingEdge":["PROX1","SIRT1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY","pval":0.13004,"padj":0.72427,"ES":0.95439,"NES":1.21455,"nMoreExtreme":7653,"size":14,"leadingEdge":["FGF10","FLT1","HIF1A"]} {"pathway":"GO_PEPTIDYL_L_CYSTEINE_S_PALMITOYLATION","pval":0.22246,"padj":0.80586,"ES":0.91358,"NES":1.2145,"nMoreExtreme":13844,"size":21,"leadingEdge":["ZDHHC19","ZDHHC18","ZDHHC11B","ZDHHC23","ZDHHC6"]} {"pathway":"GO_PURINE_NUCLEOSIDE_CATABOLIC_PROCESS","pval":0.28996,"padj":0.85125,"ES":0.94095,"NES":1.21449,"nMoreExtreme":15976,"size":8,"leadingEdge":["ENPP4","ADA2","AHCY"]} {"pathway":"GO_POSITIVE_REGULATION_OF_VIRAL_ENTRY_INTO_HOST_CELL","pval":0.29099,"padj":0.85125,"ES":0.94078,"NES":1.21428,"nMoreExtreme":16033,"size":8,"leadingEdge":["CD74","TRIM21","CD4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE","pval":0.10256,"padj":0.67367,"ES":0.71332,"NES":1.21396,"nMoreExtreme":8539,"size":145,"leadingEdge":["NOD2","RIPK2","ZC3H12A","EDN1","SLAMF1","NCF1","NRK","IL1RN","GADD45B","LYN","TLR3","GADD45G","TNF","RASGRP1","FGD2","PAK1","CCL19","PTPN1","SH3RF1","BIRC7","PLCB1","TLR4","MAPK8IP2"]} {"pathway":"GO_RIG_I_SIGNALING_PATHWAY","pval":0.17498,"padj":0.77529,"ES":0.93205,"NES":1.21387,"nMoreExtreme":10645,"size":18,"leadingEdge":["DDX60","BIRC3","DDX58","DHX58","PUM2"]} {"pathway":"GO_MITOCHONDRIAL_FRAGMENTATION_INVOLVED_IN_APOPTOTIC_PROCESS","pval":0.2203,"padj":0.80441,"ES":0.95027,"NES":1.21379,"nMoreExtreme":12310,"size":9,"leadingEdge":["ATG3","VPS35"]} {"pathway":"GO_SHORT_CHAIN_FATTY_ACID_CATABOLIC_PROCESS","pval":0.29361,"padj":0.85379,"ES":0.94039,"NES":1.21377,"nMoreExtreme":16177,"size":8,"leadingEdge":["MMAA","PCK2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_RECEPTOR_BIOSYNTHETIC_PROCESS","pval":0.22132,"padj":0.80586,"ES":0.9501,"NES":1.21357,"nMoreExtreme":12367,"size":9,"leadingEdge":["EDN1","NR1H3","HDAC6"]} {"pathway":"GO_INTERFERON_BETA_BIOSYNTHETIC_PROCESS","pval":0.39228,"padj":0.89503,"ES":0.9277,"NES":1.2135,"nMoreExtreme":21322,"size":7,"leadingEdge":["NMI","TLR8","TLR7","TLR3","TLR4","TICAM1"]} {"pathway":"GO_COPPER_ION_TRANSPORT","pval":0.13717,"padj":0.73301,"ES":0.94979,"NES":1.21349,"nMoreExtreme":8150,"size":15,"leadingEdge":["SLC31A2","STEAP4","SCO2","SLC31A1","FKBP4"]} {"pathway":"GO_LIPOPOLYSACCHARIDE_MEDIATED_SIGNALING_PATHWAY","pval":0.16597,"padj":0.77163,"ES":0.79239,"NES":1.21346,"nMoreExtreme":11784,"size":53,"leadingEdge":["ACOD1","RIPK2","CARD16","LILRA2","CCL5","LYN","TNFAIP3","TNF","PTAFR","CCL2","TGFB1","NFKBIA","CCL3","CX3CL1","TLR4","TICAM1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NON_MOTILE_CILIUM_ASSEMBLY","pval":0.52718,"padj":0.92669,"ES":0.90747,"NES":1.21345,"nMoreExtreme":28293,"size":6,"leadingEdge":["HAP1","DYNLL1"]} {"pathway":"GO_TYPE_I_INTERFERON_SECRETION","pval":0.22209,"padj":0.80586,"ES":0.94999,"NES":1.21343,"nMoreExtreme":12410,"size":9,"leadingEdge":["IFIH1","DDX58","LILRB1","MAVS"]} {"pathway":"GO_HYPEROSMOTIC_RESPONSE","pval":0.1931,"padj":0.79001,"ES":0.92528,"NES":1.2133,"nMoreExtreme":11859,"size":19,"leadingEdge":["TLR3","RCSD1","YBX3"]} {"pathway":"GO_LONG_CHAIN_FATTY_ACYL_COA_BIOSYNTHETIC_PROCESS","pval":0.13764,"padj":0.73301,"ES":0.94964,"NES":1.2133,"nMoreExtreme":8178,"size":15,"leadingEdge":["ACSL1","ACSL5","ELOVL7","ELOVL5"]} {"pathway":"GO_GLUTAMINE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS","pval":0.19354,"padj":0.79001,"ES":0.92523,"NES":1.21323,"nMoreExtreme":11886,"size":19,"leadingEdge":["GLUL","GLS","NOS2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MAST_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE","pval":0.52834,"padj":0.92669,"ES":0.9073,"NES":1.21322,"nMoreExtreme":28355,"size":6,"leadingEdge":["CD84","HMOX1"]} {"pathway":"GO_PROTEIN_K11_LINKED_DEUBIQUITINATION","pval":0.22312,"padj":0.80675,"ES":0.94982,"NES":1.21321,"nMoreExtreme":12468,"size":9,"leadingEdge":["TNFAIP3","VCPIP1","OTUB2"]} {"pathway":"GO_CHEMOKINE_C_X_C_MOTIF_LIGAND_2_PRODUCTION","pval":0.1382,"padj":0.73306,"ES":0.95796,"NES":1.21309,"nMoreExtreme":7971,"size":12,"leadingEdge":["CD74","MCOLN2","KLF4","TNF"]} {"pathway":"GO_POSITIVE_REGULATION_OF_T_CELL_RECEPTOR_SIGNALING_PATHWAY","pval":0.17725,"padj":0.77529,"ES":0.9555,"NES":1.21303,"nMoreExtreme":10004,"size":10,"leadingEdge":["CYLD","CD226","KCNN4"]} {"pathway":"GO_ACTIVATION_OF_MAPKKK_ACTIVITY","pval":0.15198,"padj":0.75292,"ES":0.95791,"NES":1.21301,"nMoreExtreme":8677,"size":11,"leadingEdge":["GADD45B","GADD45G","TNF","MAP4K3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_LEUKOCYTE_DEGRANULATION","pval":0.21121,"padj":0.79831,"ES":0.91876,"NES":1.21295,"nMoreExtreme":13055,"size":20,"leadingEdge":["HLA-F","PTAFR","FCER1G","FGR"]} {"pathway":"GO_NLRP3_INFLAMMASOME_COMPLEX_ASSEMBLY","pval":0.15245,"padj":0.75292,"ES":0.95782,"NES":1.2129,"nMoreExtreme":8704,"size":11,"leadingEdge":["GBP5","MEFV","TLR4","EIF2AK2"]} {"pathway":"GO_SERTOLI_CELL_DEVELOPMENT","pval":0.15245,"padj":0.75292,"ES":0.9578,"NES":1.21287,"nMoreExtreme":8704,"size":11,"leadingEdge":["ICAM1","SOX8","ARID4A"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TRANSMISSION_OF_NERVE_IMPULSE","pval":0.17914,"padj":0.77529,"ES":0.90997,"NES":1.21286,"nMoreExtreme":8963,"size":1,"leadingEdge":["GPR35"]} {"pathway":"GO_REGULATION_OF_CHOLESTEROL_EFFLUX","pval":0.16161,"padj":0.76688,"ES":0.93783,"NES":1.21282,"nMoreExtreme":9765,"size":17,"leadingEdge":["TTC39B","NR1H3","NFKBIA","ABCA7"]} {"pathway":"GO_REGULATION_OF_MONONUCLEAR_CELL_MIGRATION","pval":0.19564,"padj":0.79001,"ES":0.83829,"NES":1.21281,"nMoreExtreme":13105,"size":36,"leadingEdge":["CXCL10","SLAMF8","CCL5","LYN","CSF1","TNF","CCL1","CXCL12","FPR2","TGFB1","PLCB1","SLIT2","CCR1"]} {"pathway":"GO_RELAXATION_OF_SMOOTH_MUSCLE","pval":0.29936,"padj":0.85717,"ES":0.9396,"NES":1.21275,"nMoreExtreme":16494,"size":8,"leadingEdge":["SLC8A1","KCNMA1","GUCY1A1","RGS2"]} {"pathway":"GO_RESPIRATORY_BURST_INVOLVED_IN_DEFENSE_RESPONSE","pval":0.17854,"padj":0.77529,"ES":0.95527,"NES":1.21275,"nMoreExtreme":10077,"size":10,"leadingEdge":["SLAMF8","DUSP10","GRN"]} {"pathway":"GO_REGULATION_OF_SPHINGOLIPID_BIOSYNTHETIC_PROCESS","pval":0.13613,"padj":0.73267,"ES":0.95296,"NES":1.21273,"nMoreExtreme":8012,"size":14,"leadingEdge":["TNF","SMPD3","NSMAF"]} {"pathway":"GO_HUMORAL_IMMUNE_RESPONSE","pval":0.11577,"padj":0.70006,"ES":0.7226,"NES":1.21272,"nMoreExtreme":9392,"size":122,"leadingEdge":["C4A","CXCL11","C4B","SERPING1","C1QB","CXCL10","HLA-DQB1","CCL13","CFH","CFB","HLA-E","ACOD1","CXCL9","PSMB10","C2","PDCD1","C3","C1S","C1RL","C1R","LTA","IL7","CD83","IL6","TNF","EBI3","PTPRC","CCL2","A2M","CCR6","C1QC","CXCL8"]} {"pathway":"GO_COPPER_ION_HOMEOSTASIS","pval":0.14871,"padj":0.7508,"ES":0.94393,"NES":1.21264,"nMoreExtreme":8907,"size":16,"leadingEdge":["SLC31A2","SCO2","MT2A","SLC31A1"]} {"pathway":"GO_NUCLEOTIDE_SUGAR_BIOSYNTHETIC_PROCESS","pval":0.25382,"padj":0.82744,"ES":0.89968,"NES":1.2124,"nMoreExtreme":15969,"size":23,"leadingEdge":["NAGK","PGM3"]} {"pathway":"GO_RESPONSE_TO_INTERFERON_ALPHA","pval":0.19773,"padj":0.79183,"ES":0.92454,"NES":1.21233,"nMoreExtreme":12143,"size":19,"leadingEdge":["LAMP3","IFITM2","IFITM1","IFIT3","IFIT2","IFITM3","PYHIN1","ADAR","GAS6","GATA3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_HEPATOCYTE_PROLIFERATION","pval":0.5329,"padj":0.92816,"ES":0.90663,"NES":1.21232,"nMoreExtreme":28600,"size":6,"leadingEdge":["TNFAIP3","HPN","CFLAR","PTN"]} {"pathway":"GO_INTERMEDIATE_FILAMENT_ORGANIZATION","pval":0.13181,"padj":0.72756,"ES":0.95661,"NES":1.2122,"nMoreExtreme":7676,"size":13,"leadingEdge":["DES","VIM"]} {"pathway":"GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_PHOSPHATASE_SIGNALING_PATHWAY","pval":0.53376,"padj":0.92816,"ES":0.90652,"NES":1.21217,"nMoreExtreme":28646,"size":6,"leadingEdge":["PTPRU","PTN","TRIO"]} {"pathway":"GO_HEMATOPOIETIC_STEM_CELL_DIFFERENTIATION","pval":0.14779,"padj":0.7508,"ES":0.76046,"NES":1.21215,"nMoreExtreme":11053,"size":73,"leadingEdge":["PSME2","PSMB9","PSME1","PSMB10","PSMB8","PSMA4","PSMA2","RUNX1","PSMA5","FOXC1","GATA3","NFE2L2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_T_HELPER_17_CELL_DIFFERENTIATION","pval":0.39962,"padj":0.89503,"ES":0.92664,"NES":1.21212,"nMoreExtreme":21721,"size":7,"leadingEdge":["IL12RB1","IL12B"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS","pval":0.25424,"padj":0.82744,"ES":0.89946,"NES":1.2121,"nMoreExtreme":15995,"size":23,"leadingEdge":["ICAM1","TNFAIP3","ANGPTL4","GAS6","GATA3","NFE2L2","KRIT1"]} {"pathway":"GO_LABYRINTHINE_LAYER_MORPHOGENESIS","pval":0.14217,"padj":0.73965,"ES":0.94863,"NES":1.212,"nMoreExtreme":8447,"size":15,"leadingEdge":["NCOA1","SOCS3","FGFR2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_LIPID_STORAGE","pval":0.1648,"padj":0.76986,"ES":0.93711,"NES":1.21189,"nMoreExtreme":9958,"size":17,"leadingEdge":["TTC39B","IL6","TNF","NR1H3","PTPN2","NFKBIA","ABHD5"]} {"pathway":"GO_IMMATURE_T_CELL_PROLIFERATION","pval":0.53577,"padj":0.92816,"ES":0.90627,"NES":1.21184,"nMoreExtreme":28754,"size":6,"leadingEdge":["RIPK2","TMEM131L"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_CORTICOSTEROID_STIMULUS","pval":0.17867,"padj":0.77529,"ES":0.80673,"NES":1.21182,"nMoreExtreme":12435,"size":46,"leadingEdge":["SSTR2","ICAM1","BCL2L11","EDN1","FAM107A","EPHX1","TGFB1","CREBRF","CFLAR","ZFP36","ASS1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MONOCYTE_DIFFERENTIATION","pval":0.23184,"padj":0.81508,"ES":0.94843,"NES":1.21143,"nMoreExtreme":12955,"size":9,"leadingEdge":["CD74","CSF1","DCSTAMP"]} {"pathway":"GO_RESPONSE_TO_SALT_STRESS","pval":0.14407,"padj":0.74343,"ES":0.94818,"NES":1.21143,"nMoreExtreme":8560,"size":15,"leadingEdge":["TNF","KMO","XRCC5"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ER_ASSOCIATED_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS","pval":0.4034,"padj":0.89503,"ES":0.92606,"NES":1.21136,"nMoreExtreme":21926,"size":7,"leadingEdge":["NFE2L2","HERPUD1","SGTA"]} {"pathway":"GO_CYTOSOLIC_TRANSPORT","pval":0.10466,"padj":0.67994,"ES":0.71096,"NES":1.21135,"nMoreExtreme":8737,"size":147,"leadingEdge":["LRRK2","LMTK2","RHOBTB3","DOP1A","SRC","SNX16","SORT1","MAP2","CES1","AP1AR","SNX8","DNAJC13","DENND5A","TRIM46","GCC2"]} {"pathway":"GO_ACTIVATION_OF_GTPASE_ACTIVITY","pval":0.1407,"padj":0.73814,"ES":0.75057,"NES":1.2113,"nMoreExtreme":10705,"size":82,"leadingEdge":["RASGRF1","USP6NL","RASGRP1","TBC1D2B","TBC1D22B"]} {"pathway":"GO_INDOLE_CONTAINING_COMPOUND_CATABOLIC_PROCESS","pval":0.23246,"padj":0.81508,"ES":0.94831,"NES":1.21127,"nMoreExtreme":12990,"size":9,"leadingEdge":["IDO1","IDO2","KYNU","KMO"]} {"pathway":"GO_EXONUCLEOLYTIC_TRIMMING_INVOLVED_IN_RRNA_PROCESSING","pval":0.40428,"padj":0.89503,"ES":0.92595,"NES":1.21122,"nMoreExtreme":21974,"size":7,"leadingEdge":["ERI1","EXOSC7"]} {"pathway":"GO_REGULATION_OF_RECEPTOR_CATABOLIC_PROCESS","pval":0.30764,"padj":0.86308,"ES":0.93836,"NES":1.21116,"nMoreExtreme":16950,"size":8,"leadingEdge":["DTX3L","PTPN1","MYLIP"]} {"pathway":"GO_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_SIGNALING_PATHWAY","pval":0.20005,"padj":0.79183,"ES":0.84083,"NES":1.21105,"nMoreExtreme":13333,"size":35,"leadingEdge":["NOD2","RIPK2","CYLD","TNFAIP3","BIRC3","NFKBIA","TLR4"]} {"pathway":"GO_DNA_INTEGRATION","pval":0.16042,"padj":0.76421,"ES":0.95617,"NES":1.21081,"nMoreExtreme":9159,"size":11,"leadingEdge":["NYNRIN","SMARCB1"]} {"pathway":"GO_REGULATION_OF_RHODOPSIN_MEDIATED_SIGNALING_PATHWAY","pval":0.14696,"padj":0.75025,"ES":0.94761,"NES":1.21071,"nMoreExtreme":8732,"size":15,"leadingEdge":["GUCA1A","CNGB1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_BILE_ACID_METABOLIC_PROCESS","pval":0.18264,"padj":0.77906,"ES":0.90834,"NES":1.21069,"nMoreExtreme":9138,"size":1,"leadingEdge":["PROX1"]} {"pathway":"GO_ENDOTHELIAL_CELL_MIGRATION","pval":0.09328,"padj":0.66429,"ES":0.70045,"NES":1.21065,"nMoreExtreme":8013,"size":179,"leadingEdge":["CD40","CEACAM1","AMOT","AGT","KLF4","ZC3H12A","P2RX4","EDN1","VEGFC","MIR503","GLUL","PRKX","ANXA3","EGR3","STAT5A","TGFB1","SEMA4A","ROBO1","ADGRB1","PTGS2","GATA3","NFE2L2","MIR212","PDGFB","SLIT2"]} {"pathway":"GO_UBIQUITIN_DEPENDENT_SMAD_PROTEIN_CATABOLIC_PROCESS","pval":0.54172,"padj":0.9293,"ES":0.90534,"NES":1.21059,"nMoreExtreme":29073,"size":6,"leadingEdge":["WNT1","STUB1"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_COLD","pval":0.31177,"padj":0.86489,"ES":0.93775,"NES":1.21036,"nMoreExtreme":17178,"size":8,"leadingEdge":["NFKBIA","NFE2L1"]} {"pathway":"GO_SPHINGOLIPID_BIOSYNTHETIC_PROCESS","pval":0.14127,"padj":0.73885,"ES":0.74799,"NES":1.21029,"nMoreExtreme":10793,"size":84,"leadingEdge":["P2RX7","B4GALT5","TNF","SMPD3","ST3GAL5","ELOVL7","PLPP1","KDSR"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY","pval":0.23824,"padj":0.82177,"ES":0.94746,"NES":1.2102,"nMoreExtreme":13313,"size":9,"leadingEdge":["BCL2L11","PMAIP1","PTPN2","NCK2"]} {"pathway":"GO_RESPONSE_TO_CORTICOSTEROID","pval":0.12323,"padj":0.7123,"ES":0.72543,"NES":1.21014,"nMoreExtreme":9895,"size":114,"leadingEdge":["SSTR2","ICAM1","BCL2L11","EDN1","FAM107A","IL1RN","EPHX1","PTPRU","ANXA3","IL6","TNF","PTAFR","SRC","TGFB1","CDKN1A","CREBRF","PTGS2","CFLAR","PPARGC1B","ZFP36","SLIT2","ASS1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TYPE_I_INTERFERON_MEDIATED_SIGNALING_PATHWAY","pval":0.23864,"padj":0.82177,"ES":0.94741,"NES":1.21013,"nMoreExtreme":13335,"size":9,"leadingEdge":["NLRC5","PTPN2","MUL1"]} {"pathway":"GO_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND","pval":0.01414,"padj":0.30988,"ES":0.66387,"NES":1.21008,"nMoreExtreme":1392,"size":697,"leadingEdge":["CD40","P2RX7","LRRK2","CD38","IL15","PDE4B","CXCL10","NOD2","SELL","ACOD1","SSTR2","PADI2","STAT1","JAK2","AGT","PIM1","RIPK2","ACSL1","XRN1","CYP1A1","ICAM1","PAQR8","KLF4","BCL2L11","ZC3H12A","P2RX4","RAPGEF2","CASP7","GRAMD1B","RALB","EDN1","IFIH1","FAM107A","PMAIP1","IL1RN","CCL5","LYN","EPHX1","NR4A3","PTPRU","CD83","KYNU","ANXA3","IL6","TLR3","FGF10","TNF","PTGER2","SLC8A1","P2RY13","VGF","HNF4G","CCR5","NCOA1","ASCL1","CYP27B1","PTAFR","DDX58","NR1H3","NR4A2","KCNE1","CCL2","STAT3","P2RY12","PAK1","GCLC","RUNX1","SRC","TGFB1","CGAS","CDKN1A","TXNIP","NAMPT","P2RY2","NFKBIA","CREBRF","PTGS2","PLPP1","ASNS","CCL3","TRIM25","CFLAR","RGS9","NKX3-1","PPARGC1B","PDGFB","ZFP36","SLIT2","BAK1","RORB","NCOA4","ESRRB","FLOT1","CPT1A","KCNMB1","NPC1","ASS1","MTHFR","ALDH1A2"]} {"pathway":"GO_MDA_5_SIGNALING_PATHWAY","pval":0.23926,"padj":0.82313,"ES":0.94729,"NES":1.20998,"nMoreExtreme":13370,"size":9,"leadingEdge":["IRF7","IFIH1","DDX60","DHX58"]} {"pathway":"GO_TOLL_LIKE_RECEPTOR_2_SIGNALING_PATHWAY","pval":0.14949,"padj":0.75097,"ES":0.94703,"NES":1.20997,"nMoreExtreme":8882,"size":15,"leadingEdge":["ACOD1","RIPK2","LYN","TNFAIP3","PIK3AP1","TLR1"]} {"pathway":"GO_REGULATION_OF_MICROTUBULE_MOTOR_ACTIVITY","pval":0.31419,"padj":0.86489,"ES":0.93741,"NES":1.20993,"nMoreExtreme":17311,"size":8,"leadingEdge":["MAP2","PAFAH1B1"]} {"pathway":"GO_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION","pval":0.11916,"padj":0.70349,"ES":0.7219,"NES":1.20983,"nMoreExtreme":9643,"size":120,"leadingEdge":["CD274","LRRK2","NOD2","HLA-E","JAK2","RIPK2","ZC3H12A","IFIH1","SLAMF1","LILRA2","TNFAIP3","LILRA4","TLR3","CD86","GPR18","CD47","RASGRP1","PTPRC","PTAFR","DDX58","LILRB1","CCL19","GAS6","CCL3","CX3CL1","ZFP36","FCER1G","LILRA5","TLR4"]} {"pathway":"GO_MACROPHAGE_APOPTOTIC_PROCESS","pval":0.19142,"padj":0.79001,"ES":0.95297,"NES":1.20982,"nMoreExtreme":10804,"size":10,"leadingEdge":["NOD2","IRF7","CTSL","CCR5","MEF2C"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_JUN_KINASE_ACTIVITY","pval":0.15152,"padj":0.75292,"ES":0.95521,"NES":1.2096,"nMoreExtreme":8739,"size":12,"leadingEdge":["DUSP10","GSTP1"]} {"pathway":"GO_REGULATION_OF_SNARE_COMPLEX_ASSEMBLY","pval":0.24114,"padj":0.82358,"ES":0.94696,"NES":1.20955,"nMoreExtreme":13475,"size":9,"leadingEdge":["PRRT2","TRIM9","VPS41"]} {"pathway":"GO_REGULATION_OF_INTERLEUKIN_1_MEDIATED_SIGNALING_PATHWAY","pval":0.41379,"padj":0.89503,"ES":0.9246,"NES":1.20945,"nMoreExtreme":22491,"size":7,"leadingEdge":["IL1RN","VRK2","IL6","OTUD4","IL1R2"]} {"pathway":"GO_NONRIBOSOMAL_PEPTIDE_BIOSYNTHETIC_PROCESS","pval":0.19357,"padj":0.79001,"ES":0.92849,"NES":1.20923,"nMoreExtreme":11776,"size":18,"leadingEdge":["CNDP2","GGT5","CHAC1","GCLC","NFE2L2","GGCT"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS","pval":0.19469,"padj":0.79001,"ES":0.82512,"NES":1.20921,"nMoreExtreme":13223,"size":39,"leadingEdge":["CEACAM1","ACOD1","CARD16","LILRA2","TNFAIP3","DHX58","IL2RA","MICB","SIGLEC11"]} {"pathway":"GO_NUCLEOSIDE_PHOSPHATE_METABOLIC_PROCESS","pval":0.09436,"padj":0.66478,"ES":0.69929,"NES":1.2092,"nMoreExtreme":8112,"size":180,"leadingEdge":["LRRK2","CD38","GIMAP7","ACOT4","SULT1C2","GTPBP1","DGAT2","CTNS","CMPK2","MYH7","SLC25A25","KMO","ATP6V1A","RHOQ","ACSM5","ACPP","AK4","NADK"]} {"pathway":"GO_POSITIVE_REGULATION_OF_DEFENSE_RESPONSE_TO_BACTERIUM","pval":0.54878,"padj":0.93125,"ES":0.90427,"NES":1.20917,"nMoreExtreme":29452,"size":6,"leadingEdge":["SIGLEC16","GRN"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_APOPTOTIC_PROCESS","pval":0.19411,"padj":0.79001,"ES":0.92838,"NES":1.20908,"nMoreExtreme":11809,"size":18,"leadingEdge":["JAK2","CFLAR","NFE2L2","HSPB6"]} {"pathway":"GO_PERICYTE_CELL_DIFFERENTIATION","pval":0.41655,"padj":0.89503,"ES":0.92427,"NES":1.20901,"nMoreExtreme":22641,"size":7,"leadingEdge":["PDGFB","ACTA2"]} {"pathway":"GO_INTRACELLULAR_DISTRIBUTION_OF_MITOCHONDRIA","pval":0.4169,"padj":0.89503,"ES":0.92426,"NES":1.20901,"nMoreExtreme":22660,"size":7,"leadingEdge":["LRRK2","DNM1L"]} {"pathway":"GO_REGULATION_OF_TOLL_LIKE_RECEPTOR_2_SIGNALING_PATHWAY","pval":0.19582,"padj":0.79001,"ES":0.95221,"NES":1.20886,"nMoreExtreme":11052,"size":10,"leadingEdge":["ACOD1","LYN","TNFAIP3","TLR1"]} {"pathway":"GO_PARAXIAL_MESODERM_MORPHOGENESIS","pval":0.41782,"padj":0.89503,"ES":0.9241,"NES":1.20879,"nMoreExtreme":22710,"size":7,"leadingEdge":["FOXC1","SMAD3","BMPR1A"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SUPEROXIDE_ANION_GENERATION","pval":0.15358,"padj":0.75388,"ES":0.9461,"NES":1.20877,"nMoreExtreme":9125,"size":15,"leadingEdge":["AGT","FPR2","TGFB1","TYROBP"]} {"pathway":"GO_TRANSFORMING_GROWTH_FACTOR_BETA2_PRODUCTION","pval":0.4183,"padj":0.89503,"ES":0.92404,"NES":1.20872,"nMoreExtreme":22736,"size":7,"leadingEdge":["SMAD3","CDH3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_VIRAL_TRANSCRIPTION","pval":0.2602,"padj":0.82935,"ES":0.89691,"NES":1.20867,"nMoreExtreme":16370,"size":23,"leadingEdge":["TRIM31","IFITM3","CCL5","CCL4","TRIM21","CCL3","ZFP36"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MACROAUTOPHAGY","pval":0.15832,"padj":0.76311,"ES":0.77064,"NES":1.2086,"nMoreExtreme":11593,"size":64,"leadingEdge":["CALCOCO2","OPTN","RIPK2","RALB","RUFY4","UVRAG","C9orf72"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_STEM_CELL_PROLIFERATION","pval":0.2466,"padj":0.82387,"ES":0.94606,"NES":1.2084,"nMoreExtreme":13780,"size":9,"leadingEdge":["OVOL1","TGFB1","SNAI2"]} {"pathway":"GO_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY_INVOLVED_IN_HEART_PROCESS","pval":0.2466,"padj":0.82387,"ES":0.94606,"NES":1.2084,"nMoreExtreme":13780,"size":9,"leadingEdge":["SRC","ATP2B4"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PRODUCTION_OF_MIRNAS_INVOLVED_IN_GENE_SILENCING_BY_MIRNA","pval":0.2466,"padj":0.82387,"ES":0.94606,"NES":1.2084,"nMoreExtreme":13780,"size":9,"leadingEdge":["ZC3H12A","TGFB1","ZMPSTE24"]} {"pathway":"GO_DEVELOPMENT_OF_SECONDARY_SEXUAL_CHARACTERISTICS","pval":0.24703,"padj":0.82387,"ES":0.946,"NES":1.20833,"nMoreExtreme":13804,"size":9,"leadingEdge":["TGFB1","B4GALT1"]} {"pathway":"GO_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_OR_POLYSACCHARIDE_ANTIGEN_VIA_MHC_CLASS_II","pval":0.57183,"padj":0.94008,"ES":0.87836,"NES":1.20826,"nMoreExtreme":30257,"size":5,"leadingEdge":["HLA-DOA","HLA-DOB","PYCARD"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS","pval":0.006,"padj":0.20106,"ES":0.66083,"NES":1.20819,"nMoreExtreme":595,"size":924,"leadingEdge":["IRF1","IDO1","ASCL2","GBP1","CD74","P2RX7","SOCS1","CD274","LRRK2","CD38","PDCD1LG2","IL15","SERPING1","LAG3","PDE4B","TBX21","CXCL10","HLA-F","CEACAM1","AMOT","HGF","KREMEN1","NLRC5","ACOD1","BANK1","CHRD","NMI","STAT1","CTLA4","JAK2","AGT","TMEM176A","TMEM176B","TLR8","UBE2L6","SPTBN4","KLF4","LILRB3","PDCD1","PML","SRI","B2M","MEFV","ZC3H12A","JAK3","CYLD","P2RX4","RAPGEF2","CARD17","STAP1","CARD16","NPR1","BTN2A2","EDN1","IFIH1","SLAMF1","MIR503","HLA-G","SLAMF8","PTGER4","DYNLT1","RELB","BCL6","LYN","IL12A","TIFAB","PARP3","CD83","TNFAIP3","LILRA4","CTSZ","IL6","TLR3","LILRB4","SEMA7A","TNF","SOX8","HPN","PROCR","DUSP10","GPR18","ASCL1","NTN1","PTPRC","DDX58","NR1H3","LILRB1","STAT3","PTPN2","DHX58","PAK1","RUNX1","TGFB1","SEMA4A","KCNMA1","ROBO1","C1QC","GP1BA","PDGFRA","IKBKE","GUCY1A1","ISL2","NFKBIA","MAP2","RGMA","ADGRB1","ISG15","LPAR1","PTGS2","GAS6","CCL3","CX3CL1","FOXC1","TRIM25","GATA3","NKX3-1","NFE2L2","IL33","LIN28A","MIR212","SEMA4D"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR","pval":0.23148,"padj":0.81508,"ES":0.9151,"NES":1.20812,"nMoreExtreme":14308,"size":20,"leadingEdge":["PMAIP1","PYHIN1","HIC1"]} {"pathway":"GO_COMPLEMENT_ACTIVATION","pval":0.19988,"padj":0.79183,"ES":0.83127,"NES":1.20776,"nMoreExtreme":13445,"size":37,"leadingEdge":["C4A","C4B","SERPING1","C1QB","CFH","CFB","C2","C3","C1S","C1RL","C1R","A2M","C1QC"]} {"pathway":"GO_PARENTAL_BEHAVIOR","pval":0.32629,"padj":0.87041,"ES":0.93567,"NES":1.20768,"nMoreExtreme":17978,"size":8,"leadingEdge":["CREBRF","ZFX"]} {"pathway":"GO_PEPTIDYL_THREONINE_DEPHOSPHORYLATION","pval":0.16609,"padj":0.77167,"ES":0.94002,"NES":1.20761,"nMoreExtreme":9948,"size":16,"leadingEdge":["PPM1E","DUSP10","DUSP5","PPP5C"]} {"pathway":"GO_RESPONSE_TO_REDOX_STATE","pval":0.14948,"padj":0.75097,"ES":0.9529,"NES":1.2075,"nMoreExtreme":8705,"size":13,"leadingEdge":["SMPD3","GLRX2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_2_SIGNALING_PATHWAY","pval":0.55716,"padj":0.93517,"ES":0.90298,"NES":1.20744,"nMoreExtreme":29902,"size":6,"leadingEdge":["TLR1","CYBA"]} {"pathway":"GO_REGULATION_OF_RESPONSE_TO_OSMOTIC_STRESS","pval":0.32872,"padj":0.87192,"ES":0.93533,"NES":1.20724,"nMoreExtreme":18112,"size":8,"leadingEdge":["ABCB1","PTGS2","BAD"]} {"pathway":"GO_INTERLEUKIN_21_MEDIATED_SIGNALING_PATHWAY","pval":0.42601,"padj":0.89839,"ES":0.92286,"NES":1.20717,"nMoreExtreme":23155,"size":7,"leadingEdge":["STAT1","JAK3","IL2RG","STAT3","STAT4","IL21R"]} {"pathway":"GO_REGULATION_OF_NEUTROPHIL_ACTIVATION","pval":0.20581,"padj":0.79637,"ES":0.95038,"NES":1.20654,"nMoreExtreme":11616,"size":10,"leadingEdge":["PTAFR","GRN"]} {"pathway":"GO_REGULATION_OF_MICROTUBULE_BASED_MOVEMENT","pval":0.25451,"padj":0.82744,"ES":0.90756,"NES":1.2065,"nMoreExtreme":15839,"size":21,"leadingEdge":["DNAAF1","MAP2","TRIM46","HAP1"]} {"pathway":"GO_AXON_ENSHEATHMENT_IN_CENTRAL_NERVOUS_SYSTEM","pval":0.16236,"padj":0.76748,"ES":0.94421,"NES":1.20636,"nMoreExtreme":9647,"size":15,"leadingEdge":["KCNJ10","B4GALT5","ERCC2"]} {"pathway":"GO_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_REMOVAL","pval":0.07235,"padj":0.62163,"ES":0.68195,"NES":1.20635,"nMoreExtreme":6560,"size":266,"leadingEdge":["PSME2","PSMB9","PSME1","PSMB10","PSMB8","STAMBPL1","ZC3H12A","CYLD","IFIH1","POLB","TANK","EPOP","OTUD1","TNFAIP3","BIRC3","ATXN7","PSMA4","PSMA2","DDX58","VCPIP1","PSMA5","TRIM21","NFKBIA","OTUD4","USP18","GATA3","IL33","CCNA1","SMAD3","KDM1B"]} {"pathway":"GO_REGULATION_OF_MITOPHAGY","pval":0.17108,"padj":0.77295,"ES":0.93904,"NES":1.20634,"nMoreExtreme":10247,"size":16,"leadingEdge":["OPTN","CLEC16A"]} {"pathway":"GO_PHAGOCYTOSIS","pval":0.08161,"padj":0.64487,"ES":0.68767,"NES":1.20633,"nMoreExtreme":7244,"size":228,"leadingEdge":["IL15RA","C4A","P2RX7","C4B","IL15","C2","TGM2","C3","CD300LF","STAP1","RAB20","SLAMF1","DYSF","XKR6","LYN","ANXA3","ARHGAP25","IL2RG","TNF","CD47","CAMK1D","ITGAL","XKR8","PTPRC","ATG3","NR1H3","FCGR1A","CCL2","PAK1","SRC","TGFB1","ADGRB1","NCF2","GAS6","XKR7","ELMO2","RAB39A","CDC42SE2","FCER1G"]} {"pathway":"GO_CYTOKINE_PRODUCTION_INVOLVED_IN_INFLAMMATORY_RESPONSE","pval":0.22263,"padj":0.80587,"ES":0.85877,"NES":1.20615,"nMoreExtreme":14512,"size":30,"leadingEdge":["GBP5","IDO1","NOD2","MEFV","ZC3H12A","MYD88","IL1R2","TLR4"]} {"pathway":"GO_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY","pval":0.03343,"padj":0.46677,"ES":0.66656,"NES":1.20613,"nMoreExtreme":3218,"size":484,"leadingEdge":["CEACAM1","ADGRE5","SELL","HLA-E","PADI2","FGL2","LILRB3","ENPP4","GSDMD","B2M","C3","S100A13","CTSS","IGF2R","MVP","DYNLT1","LYN","TNFAIP6","MMP25","TICAM2","NR4A3","ANXA3","CTSZ","IL6","CLEC4D","PSMA2","SERPINB9","CD47","RASGRP1","RAB24","ITGAL","PTPRC","CHI3L1","PTAFR","DDX58","FPR2","MNDA","PSMA5","ADA2","CTSC","GM2A","CREG1","HVCN1","CCL3","ACPP","SLC44A2","DNAJC13","SERPINB1","CD53","GNS","CRISPLD2","STOM","NFAM1","FCER1G","FCGR3B","CXCL1"]} {"pathway":"GO_PANCREATIC_JUICE_SECRETION","pval":0.20783,"padj":0.79637,"ES":0.95004,"NES":1.20612,"nMoreExtreme":11730,"size":10,"leadingEdge":["NR1H3","WNK1"]} {"pathway":"GO_MYELOID_DENDRITIC_CELL_DIFFERENTIATION","pval":0.17211,"padj":0.77295,"ES":0.93885,"NES":1.2061,"nMoreExtreme":10309,"size":16,"leadingEdge":["UBD","BATF2","BATF3","RELB","IRF4","TGFB1","DCSTAMP"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_OXYGEN_LEVELS","pval":0.09106,"padj":0.66096,"ES":0.69273,"NES":1.20602,"nMoreExtreme":7941,"size":199,"leadingEdge":["PSME2","PSMB9","PSME1","PSMB10","FAS","PSMB8","ICAM1","CARD16","EDN1","PMAIP1","BACH1","PSMA4","SLC8A1","PSMA2","SRC","PSMA5","ATP6V1A","NAMPT","LPAR1","PTGS2","CFLAR","NKX3-1","NFE2L2"]} {"pathway":"GO_REGULATION_OF_HEART_RATE","pval":0.15757,"padj":0.76265,"ES":0.76058,"NES":1.20599,"nMoreExtreme":11700,"size":70,"leadingEdge":["GCH1","AGT","KCNJ2","CAMK2D","SPTBN4","SRI","EDN1","ANK2","KCNE5","MYH7","SLC8A1","KCNE1"]} {"pathway":"GO_LEUKOCYTE_APOPTOTIC_PROCESS","pval":0.13769,"padj":0.73301,"ES":0.73504,"NES":1.20596,"nMoreExtreme":10743,"size":96,"leadingEdge":["IDO1","CD74","P2RX7","CD274","NOD2","HCAR2","BCL2L11","PDCD1","JAK3","RAPGEF2","IRF7","GIMAP8","BCL6","CCL5","LYN","NR4A3","CTSL","IL6","CCR5","CXCL12","LILRB1","IL2RA","CCL19","GAS6","PRELID1","BIRC7","BAK1","FCER1G"]} {"pathway":"GO_KIDNEY_MORPHOGENESIS","pval":0.14925,"padj":0.75097,"ES":0.75001,"NES":1.20588,"nMoreExtreme":11299,"size":79,"leadingEdge":["LRRK2","STAT1","AGT","GCNT3","PRKX","FGF10","SOX8","TGFB1","GATA3","HOXD11","WNT1","HNF1B","SIX1","GCNT1"]} {"pathway":"GO_BINDING_OF_SPERM_TO_ZONA_PELLUCIDA","pval":0.25721,"padj":0.82758,"ES":0.90706,"NES":1.20583,"nMoreExtreme":16007,"size":21,"leadingEdge":["ASTL","SPA17"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND","pval":0.03915,"padj":0.50871,"ES":0.66803,"NES":1.20579,"nMoreExtreme":3742,"size":440,"leadingEdge":["P2RX7","LRRK2","IL15","PDE4B","NOD2","ACOD1","SSTR2","PADI2","STAT1","JAK2","PIM1","XRN1","CYP1A1","ICAM1","PAQR8","KLF4","BCL2L11","ZC3H12A","P2RX4","RAPGEF2","CASP7","GRAMD1B","RALB","EDN1","IFIH1","FAM107A","CCL5","EPHX1","NR4A3","TLR3","TNF","SLC8A1","P2RY13","HNF4G","NCOA1","CYP27B1","PTAFR","DDX58","NR1H3","NR4A2","KCNE1","CCL2","STAT3","P2RY12","PAK1","GCLC","RUNX1","SRC","TGFB1","CGAS","P2RY2","CREBRF","PTGS2","PLPP1","CCL3","CFLAR","NKX3-1","PPARGC1B","PDGFB","ZFP36","RORB","NCOA4","ESRRB","FLOT1","KCNMB1","NPC1","ASS1"]} {"pathway":"GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION","pval":0.02256,"padj":0.3799,"ES":0.66318,"NES":1.20564,"nMoreExtreme":2203,"size":599,"leadingEdge":["AIM2","CD40","GBP1","P2RX7","SOCS1","CD274","LRRK2","CD38","NOD2","CLEC9A","ATP13A2","HLA-E","BANK1","HCAR2","JAK2","IFI27","RIPK2","TLR8","SIDT2","CLEC6A","GSDMD","PML","SRI","TLR10","ZC3H12A","CARD17","CARD16","RSAD2","BTN2A2","VEGFC","IFIH1","PMAIP1","LILRA2","NUCB1","PTGER4","CCL5","LYN","GLUL","TNFRSF14","TNFAIP3","EDEM1","IL6","CLEC4E","TXN","TNF","RASGRP1","CCL1","DDX58","NR1H3","LILRB1","KCNE1","PAK1","SRC","TGFB1","CCL19","UCP2","RHBDF2","PTPN1","PTGS2","GAS6","PARL","CCL3","CX3CL1","GATA3","CASP1","SRCIN1","IL33","BBC3","NADK","IL1R2","SMAD3","IL1A","STOM","PRR5L"]} {"pathway":"GO_WATER_TRANSPORT","pval":0.56484,"padj":0.93517,"ES":0.90157,"NES":1.20556,"nMoreExtreme":30314,"size":6,"leadingEdge":["HAS2","AQP9","HYAL2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY","pval":0.22664,"padj":0.81317,"ES":0.91938,"NES":1.20556,"nMoreExtreme":13919,"size":19,"leadingEdge":["CYLD","STAP1","LYN","CD226","PTPRC","NFAM1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_GLYCOPROTEIN_BIOSYNTHETIC_PROCESS","pval":0.2088,"padj":0.79637,"ES":0.92562,"NES":1.20549,"nMoreExtreme":12703,"size":18,"leadingEdge":["IL15","SOAT1","CCL19","PLCB1","POMT2"]} {"pathway":"GO_RESPONSE_TO_MERCURY_ION","pval":0.56518,"padj":0.93517,"ES":0.90152,"NES":1.20549,"nMoreExtreme":30332,"size":6,"leadingEdge":["AQP9","UBE2D3"]} {"pathway":"GO_URETERIC_BUD_FORMATION","pval":0.56518,"padj":0.93517,"ES":0.90152,"NES":1.20549,"nMoreExtreme":30332,"size":6,"leadingEdge":["GATA3","SIX1","SIX4"]} {"pathway":"GO_MODULATION_OF_TRANSCRIPTION_IN_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION","pval":0.2372,"padj":0.82177,"ES":0.87272,"NES":1.20548,"nMoreExtreme":15251,"size":27,"leadingEdge":["CCL5","HPN","CCL4","CCL3","GTF2B"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ODONTOGENESIS","pval":0.43532,"padj":0.90091,"ES":0.9214,"NES":1.20527,"nMoreExtreme":23661,"size":7,"leadingEdge":["EDN1","CSF1","TGFB1"]} {"pathway":"GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CILIUM","pval":0.43568,"padj":0.9012,"ES":0.92134,"NES":1.20519,"nMoreExtreme":23681,"size":7,"leadingEdge":["GAS8","CROCC"]} {"pathway":"GO_RESPONSE_TO_OXIDATIVE_STRESS","pval":0.05237,"padj":0.55686,"ES":0.67179,"NES":1.20512,"nMoreExtreme":4926,"size":364,"leadingEdge":["IL18BP","LRRK2","GCH1","CD38","HGF","ATP13A2","STAT1","MSRB1","JAK2","KLF4","PML","ZC3H12A","EDN1","NCF1","VRK2","NR4A3","SOD2","TNFAIP3","IL6","TXN","RBM11","TNF","SLC8A1","SMPD3","NR4A2","GCLC","SRC","CCL19","UCP2","TXNIP","PRDX1","PDGFRA","C19orf12","MCL1","PTGS2","NME8","NCF2","GUCY1B1","CFLAR","NFE2L2","PPARGC1B","MICB","BAK1","PRR5L"]} {"pathway":"GO_REGULATION_OF_T_HELPER_17_TYPE_IMMUNE_RESPONSE","pval":0.16706,"padj":0.77278,"ES":0.9432,"NES":1.20507,"nMoreExtreme":9926,"size":15,"leadingEdge":["IL12RB1","TBX21","ZC3H12A","PRKCQ"]} {"pathway":"GO_REGULATION_OF_HIGH_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY","pval":0.16929,"padj":0.77295,"ES":0.95156,"NES":1.20498,"nMoreExtreme":9764,"size":12,"leadingEdge":["PDE4B","SRI","DYSF","GEM"]} {"pathway":"GO_T_HELPER_1_CELL_DIFFERENTIATION","pval":0.21138,"padj":0.79831,"ES":0.92521,"NES":1.20496,"nMoreExtreme":12860,"size":18,"leadingEdge":["RIPK2","IL27","CD80","JAK3","RELB","SEMA4A","CCL19","HLX"]} {"pathway":"GO_PURINE_NUCLEOTIDE_TRANSPORT","pval":0.15927,"padj":0.76421,"ES":0.95082,"NES":1.20486,"nMoreExtreme":9275,"size":13,"leadingEdge":["ABCC11","SLC25A25","SLC25A5"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NATURAL_KILLER_CELL_DIFFERENTIATION","pval":0.3415,"padj":0.87818,"ES":0.93348,"NES":1.20485,"nMoreExtreme":18816,"size":8,"leadingEdge":["IL15","FLT3LG","RASGRP1","GAS6"]} {"pathway":"GO_REGULATION_OF_DENDRITIC_CELL_CHEMOTAXIS","pval":0.3415,"padj":0.87818,"ES":0.93348,"NES":1.20485,"nMoreExtreme":18816,"size":8,"leadingEdge":["SLAMF8","IL12A","CCR6","GAS6"]} {"pathway":"GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSPORT","pval":0.21282,"padj":0.7999,"ES":0.84442,"NES":1.20482,"nMoreExtreme":14067,"size":33,"leadingEdge":["ATP1B2","KCNJ2","ANK2","KCNE5","RNF207","KCNE1","ACTN2","KCNMB1"]} {"pathway":"GO_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY","pval":0.13764,"padj":0.73301,"ES":0.73199,"NES":1.2047,"nMoreExtreme":10797,"size":99,"leadingEdge":["LMTK2","JAK2","TNF","PTPRC","ELFN1","MYOZ1","PPP1R16B","PTN","EIF2AK2"]} {"pathway":"GO_POLYOL_TRANSPORT","pval":0.43984,"padj":0.90126,"ES":0.92088,"NES":1.20458,"nMoreExtreme":23907,"size":7,"leadingEdge":["SLC2A13","AQP9"]} {"pathway":"GO_GOLGI_TO_ENDOSOME_TRANSPORT","pval":0.19586,"padj":0.79001,"ES":0.93142,"NES":1.20453,"nMoreExtreme":11835,"size":17,"leadingEdge":["DOP1A","SORT1","AP1AR","MON2"]} {"pathway":"GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_INDEPENDENT_DECAY","pval":0.44041,"padj":0.90126,"ES":0.92073,"NES":1.20438,"nMoreExtreme":23938,"size":7,"leadingEdge":["ZFP36","EDC4"]} {"pathway":"GO_BRANCHING_INVOLVED_IN_LABYRINTHINE_LAYER_MORPHOGENESIS","pval":0.21651,"padj":0.80167,"ES":0.94858,"NES":1.20426,"nMoreExtreme":12220,"size":10,"leadingEdge":["SOCS3","FGFR2"]} {"pathway":"GO_GROWTH_PLATE_CARTILAGE_DEVELOPMENT","pval":0.23866,"padj":0.82177,"ES":0.87179,"NES":1.20421,"nMoreExtreme":15345,"size":27,"leadingEdge":["COMP","COCH","COL27A1"]} {"pathway":"GO_OLFACTORY_BULB_INTERNEURON_DIFFERENTIATION","pval":0.44185,"padj":0.90177,"ES":0.9205,"NES":1.20409,"nMoreExtreme":24016,"size":7,"leadingEdge":["ATF5","ROBO1","SLIT2"]} {"pathway":"GO_CORTICOSPINAL_TRACT_MORPHOGENESIS","pval":0.4426,"padj":0.90221,"ES":0.92039,"NES":1.20394,"nMoreExtreme":24057,"size":7,"leadingEdge":["SLIT2","NIN"]} {"pathway":"GO_REFLEX","pval":0.163,"padj":0.76827,"ES":0.95009,"NES":1.20393,"nMoreExtreme":9492,"size":13,"leadingEdge":["NR4A3","HPN","ASCL1","AUTS2","USP46"]} {"pathway":"GO_MEMBRANE_FISSION","pval":0.18897,"padj":0.78592,"ES":0.95072,"NES":1.20391,"nMoreExtreme":10789,"size":11,"leadingEdge":["MX1","SPAST"]} {"pathway":"GO_REVERSE_CHOLESTEROL_TRANSPORT","pval":0.18981,"padj":0.78784,"ES":0.9506,"NES":1.20376,"nMoreExtreme":10837,"size":11,"leadingEdge":["LIPG","SCARB1"]} {"pathway":"GO_INTERLEUKIN_27_MEDIATED_SIGNALING_PATHWAY","pval":0.21885,"padj":0.80167,"ES":0.94819,"NES":1.20376,"nMoreExtreme":12352,"size":10,"leadingEdge":["STAT1","JAK2","IL27","EBI3","STAT3"]} {"pathway":"GO_ACTIVATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS_BY_CYTOCHROME_C","pval":0.44365,"padj":0.90337,"ES":0.92022,"NES":1.20372,"nMoreExtreme":24114,"size":7,"leadingEdge":["BAK1","BAX"]} {"pathway":"GO_WOUND_HEALING_INVOLVED_IN_INFLAMMATORY_RESPONSE","pval":0.44433,"padj":0.90355,"ES":0.92011,"NES":1.20357,"nMoreExtreme":24151,"size":7,"leadingEdge":["TGFB1","IL1A","HMOX1"]} {"pathway":"GO_RADIAL_GLIAL_CELL_DIFFERENTIATION","pval":0.22019,"padj":0.80441,"ES":0.94802,"NES":1.20355,"nMoreExtreme":12428,"size":10,"leadingEdge":["FGF10","STAT3","RHOA"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_BIOSYNTHETIC_PROCESS","pval":0.19243,"padj":0.79001,"ES":0.9501,"NES":1.20312,"nMoreExtreme":10987,"size":11,"leadingEdge":["DGAT2","NR1H3","SREBF1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION","pval":0.16144,"padj":0.76656,"ES":0.76021,"NES":1.20291,"nMoreExtreme":11948,"size":69,"leadingEdge":["LRRK2","NOD2","HLA-E","JAK2","RIPK2","IFIH1","LILRA2","TLR3","CD86","RASGRP1","PTPRC","PTAFR","DDX58","CCL19","CCL3","FCER1G","LILRA5","TLR4"]} {"pathway":"GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS","pval":0.18487,"padj":0.77988,"ES":0.7939,"NES":1.20289,"nMoreExtreme":12971,"size":49,"leadingEdge":["HGF","TNFSF10","ATF3","FAS","ICAM1","PMAIP1","TNFAIP3","CFLAR"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY","pval":0.17246,"padj":0.77332,"ES":0.9452,"NES":1.20285,"nMoreExtreme":10150,"size":14,"leadingEdge":["TBX21","HLA-F","CEACAM1","HLA-G","PTPRC","LILRB1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_DIFFERENTIATION","pval":0.22212,"padj":0.80586,"ES":0.92343,"NES":1.20264,"nMoreExtreme":13513,"size":18,"leadingEdge":["TBX21","ZC3H12A","JAK3","BCL6","RUNX1","HLX"]} {"pathway":"GO_REGULATION_OF_GRANULOCYTE_CHEMOTAXIS","pval":0.21859,"padj":0.80167,"ES":0.84734,"NES":1.20258,"nMoreExtreme":14374,"size":32,"leadingEdge":["CD74","EDN1","DYSF","CCL5","CSF1","CAMK1D","CCL19","CXCL8","RIPOR2","DAPK2","SLIT2"]} {"pathway":"GO_RESPONSE_TO_OXYGEN_GLUCOSE_DEPRIVATION","pval":0.27577,"padj":0.83896,"ES":0.94139,"NES":1.20245,"nMoreExtreme":15410,"size":9,"leadingEdge":["NAMPT","DNM1L"]} {"pathway":"GO_FATTY_ACID_ELONGATION","pval":0.18028,"padj":0.77529,"ES":0.94953,"NES":1.20241,"nMoreExtreme":10398,"size":12,"leadingEdge":["ELOVL7","ELOVL5"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY","pval":0.22595,"padj":0.81244,"ES":0.94707,"NES":1.20233,"nMoreExtreme":12753,"size":10,"leadingEdge":["PAK1","MED1"]} {"pathway":"GO_HISTAMINE_TRANSPORT","pval":0.22662,"padj":0.81317,"ES":0.94698,"NES":1.20223,"nMoreExtreme":12791,"size":10,"leadingEdge":["EDN1","LYN","BTK"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NAD_P_H_OXIDASE_ACTIVITY","pval":0.452,"padj":0.90517,"ES":0.91904,"NES":1.20218,"nMoreExtreme":24568,"size":7,"leadingEdge":["AGT","RFK","CYBA"]} {"pathway":"GO_WATER_SOLUBLE_VITAMIN_BIOSYNTHETIC_PROCESS","pval":0.452,"padj":0.90517,"ES":0.91904,"NES":1.20218,"nMoreExtreme":24568,"size":7,"leadingEdge":["MMAA","RFK","PNPO"]} {"pathway":"GO_COAGULATION","pval":0.0814,"padj":0.64463,"ES":0.68248,"NES":1.20216,"nMoreExtreme":7301,"size":246,"leadingEdge":["IRF1","CD40","P2RX7","SERPING1","CEACAM1","PLEK","JAK2","ENPP4","TSPAN32","P2RX4","EDN1","MAFF","COMP","LYN","DTNBP1","PLSCR1","IL6","PROCR","DGKG","F2RL2","LCP2","F3","SH2B2","P2RY12","SRC","A2M","GP1BA","PDGFRA","GAS6","GATA3","IRF2","NFE2L2","PDGFB"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PROTEIN_MATURATION","pval":0.26844,"padj":0.83693,"ES":0.89193,"NES":1.20196,"nMoreExtreme":16889,"size":23,"leadingEdge":["LRRK2","CARD16","CHAC1","BIRC3","CTSZ","BIRC7","IL1R2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_T_HELPER_CELL_DIFFERENTIATION","pval":0.17594,"padj":0.77529,"ES":0.94447,"NES":1.20193,"nMoreExtreme":10355,"size":14,"leadingEdge":["TBX21","ZC3H12A","JAK3","BCL6","HLX"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_REGULATED_SECRETORY_PATHWAY","pval":0.26865,"padj":0.83693,"ES":0.89186,"NES":1.20187,"nMoreExtreme":16902,"size":23,"leadingEdge":["HLA-F","CEACAM1","TRIM9","CD84"]} {"pathway":"GO_HISTONE_H2A_MONOUBIQUITINATION","pval":0.20677,"padj":0.79637,"ES":0.92934,"NES":1.20184,"nMoreExtreme":12494,"size":17,"leadingEdge":["PCGF5","KDM2B"]} {"pathway":"GO_RETINAL_ROD_CELL_DEVELOPMENT","pval":0.4536,"padj":0.90517,"ES":0.91876,"NES":1.20181,"nMoreExtreme":24655,"size":7,"leadingEdge":["RORB","NAGLU"]} {"pathway":"GO_CALCIUM_IMPORT_INTO_THE_MITOCHONDRION","pval":0.1986,"padj":0.79183,"ES":0.94903,"NES":1.20177,"nMoreExtreme":11339,"size":11,"leadingEdge":["PSEN2","MCUB"]} {"pathway":"GO_GRANULOCYTE_MIGRATION","pval":0.13806,"padj":0.73306,"ES":0.72582,"NES":1.20175,"nMoreExtreme":10949,"size":105,"leadingEdge":["CD74","CXCL11","PDE4B","CXCL10","CCL13","CXCL9","CCL7","MCOLN2","CCL15","CCL8","EDN1","IL1RN","DYSF","SLAMF8","PTGER4","CCL18","CCL5","CSF1","CAMK1D","CCL1","CCL4","CCL2","CCL19","CXCL8","RIPOR2","CCL3","CX3CL1","DAPK2","SLIT2","FCER1G"]} {"pathway":"GO_CALCIUM_ION_EXPORT","pval":0.35876,"padj":0.89036,"ES":0.93106,"NES":1.20173,"nMoreExtreme":19767,"size":8,"leadingEdge":["RGS9","ATP2B4"]} {"pathway":"GO_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS","pval":0.04207,"padj":0.51992,"ES":0.66568,"NES":1.20167,"nMoreExtreme":4022,"size":441,"leadingEdge":["PSME2","LRRK2","PSMB9","FBXO6","LAMP3","TBX21","PSME1","PSMB10","NUB1","IFI27","PSMB8","PML","RNF19B","PMAIP1","EDEM1","RNF144B","PSMA4","PSMA2","SPOPL","RBCK1","CUL1","TRIM72","UBE2A","TRIM71","TRIM9","GCLC","PSMA5","TRIM25","ERLIN1","NFE2L2","IL33","HERPUD1","NUPR1","RNF19A","UBR1","CDC26"]} {"pathway":"GO_INDOLE_CONTAINING_COMPOUND_METABOLIC_PROCESS","pval":0.17198,"padj":0.77295,"ES":0.94829,"NES":1.20166,"nMoreExtreme":10015,"size":13,"leadingEdge":["IDO1","IDO2","KYNU","KMO"]} {"pathway":"GO_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS","pval":0.15591,"padj":0.75836,"ES":0.74958,"NES":1.20145,"nMoreExtreme":11747,"size":77,"leadingEdge":["IDO1","CD74","P2RX7","CD274","NOD2","HCAR2","PDCD1","JAK3","RAPGEF2","IRF7","GIMAP8","BCL6","CCL5","LYN","NR4A3","CCR5","CXCL12","LILRB1","CCL19","GAS6","PRELID1","BIRC7"]} {"pathway":"GO_POST_EMBRYONIC_CAMERA_TYPE_EYE_DEVELOPMENT","pval":0.45616,"padj":0.90517,"ES":0.91844,"NES":1.20139,"nMoreExtreme":24794,"size":7,"leadingEdge":["KLF4","BAK1","BAX"]} {"pathway":"GO_SPONGIOTROPHOBLAST_LAYER_DEVELOPMENT","pval":0.2006,"padj":0.79183,"ES":0.94869,"NES":1.20134,"nMoreExtreme":11453,"size":11,"leadingEdge":["ASCL2","NRK","SOCS3","ZFAT"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION","pval":0.11508,"padj":0.70006,"ES":0.70384,"NES":1.20133,"nMoreExtreme":9640,"size":150,"leadingEdge":["GBP1","LRRK2","BANK1","TLR8","PML","ZC3H12A","CARD17","CARD16","RSAD2","BTN2A2","PTGER4","TNFAIP3","TXN","TNF","NR1H3","LILRB1","KCNE1","UCP2","RHBDF2","GAS6","CX3CL1","SRCIN1","IL33","IL1R2"]} {"pathway":"GO_SMALL_RNA_LOADING_ONTO_RISC","pval":0.28153,"padj":0.8439,"ES":0.9405,"NES":1.2013,"nMoreExtreme":15732,"size":9,"leadingEdge":["ADAR","AGO1"]} {"pathway":"GO_RESPONSE_TO_NITROSATIVE_STRESS","pval":0.23079,"padj":0.81508,"ES":0.94622,"NES":1.20126,"nMoreExtreme":13026,"size":10,"leadingEdge":["GCLC","GCLM"]} {"pathway":"GO_REGULATION_OF_LAMELLIPODIUM_MORPHOGENESIS","pval":0.23162,"padj":0.81508,"ES":0.94611,"NES":1.20112,"nMoreExtreme":13073,"size":10,"leadingEdge":["ENPP2","SRC","CD44"]} {"pathway":"GO_AMINE_BIOSYNTHETIC_PROCESS","pval":0.19285,"padj":0.79001,"ES":0.93491,"NES":1.20105,"nMoreExtreme":11551,"size":16,"leadingEdge":["SAT1","AZIN2","MOXD1"]} {"pathway":"GO_EARLY_ENDOSOME_TO_GOLGI_TRANSPORT","pval":0.36384,"padj":0.89036,"ES":0.93033,"NES":1.20079,"nMoreExtreme":20047,"size":8,"leadingEdge":["SNX8","EHD3"]} {"pathway":"GO_UNSATURATED_FATTY_ACID_BIOSYNTHETIC_PROCESS","pval":0.21817,"padj":0.80167,"ES":0.84159,"NES":1.20078,"nMoreExtreme":14421,"size":33,"leadingEdge":["CD74","EDN1","CBR1","ELOVL7","PTGS2"]} {"pathway":"GO_MAINTENANCE_OF_POSTSYNAPTIC_SPECIALIZATION_STRUCTURE","pval":0.58532,"padj":0.94167,"ES":0.89798,"NES":1.20075,"nMoreExtreme":31413,"size":6,"leadingEdge":["DLG3","DLG1"]} {"pathway":"GO_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS","pval":0.58556,"padj":0.94167,"ES":0.89797,"NES":1.20074,"nMoreExtreme":31426,"size":6,"leadingEdge":["LMF1","PANK2"]} {"pathway":"GO_IMMUNE_RESPONSE_INHIBITING_SIGNAL_TRANSDUCTION","pval":0.46023,"padj":0.90517,"ES":0.91787,"NES":1.20064,"nMoreExtreme":25015,"size":7,"leadingEdge":["HLA-G","LYN","LILRB1","CLEC12B","LILRB2"]} {"pathway":"GO_ACUTE_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS","pval":0.19552,"padj":0.79001,"ES":0.93448,"NES":1.20049,"nMoreExtreme":11711,"size":16,"leadingEdge":["IL31RA","HLA-E","ICAM1","C3","GATA3","FCER1G"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_AXON","pval":0.46151,"padj":0.90517,"ES":0.91769,"NES":1.20041,"nMoreExtreme":25085,"size":7,"leadingEdge":["TRIM46","EPB41L3"]} {"pathway":"GO_PYRIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS","pval":0.22462,"padj":0.81022,"ES":0.85036,"NES":1.20038,"nMoreExtreme":14704,"size":31,"leadingEdge":["IDO1","IDO2","PARP10","PARP9","KYNU","KMO","NAMPT","PTGS2","NADK"]} {"pathway":"GO_RESPONSE_TO_HYDROPEROXIDE","pval":0.21332,"padj":0.7999,"ES":0.92818,"NES":1.20035,"nMoreExtreme":12890,"size":17,"leadingEdge":["CD38","JAK2","MGST1"]} {"pathway":"GO_MAINTENANCE_OF_LOCATION_IN_CELL","pval":0.15376,"padj":0.754,"ES":0.74465,"NES":1.2003,"nMoreExtreme":11681,"size":81,"leadingEdge":["SPTBN4","PML","SRI","SCIN","TMSB10","TXN","UVRAG"]} {"pathway":"GO_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS_VIA_THE_MULTIVESICULAR_BODY_SORTING_PATHWAY","pval":0.26537,"padj":0.83566,"ES":0.90897,"NES":1.20003,"nMoreExtreme":16403,"size":20,"leadingEdge":["RNF115","NEDD4"]} {"pathway":"GO_GLUCOCORTICOID_BIOSYNTHETIC_PROCESS","pval":0.36841,"padj":0.89036,"ES":0.9297,"NES":1.19998,"nMoreExtreme":20299,"size":8,"leadingEdge":["HSD11B1","DKK3"]} {"pathway":"GO_ENDOSOMAL_VESICLE_FUSION","pval":0.28887,"padj":0.84959,"ES":0.93943,"NES":1.19994,"nMoreExtreme":16142,"size":9,"leadingEdge":["SAMD9L","SAMD9","VPS41"]} {"pathway":"GO_REGULATION_OF_PSEUDOPODIUM_ASSEMBLY","pval":0.2367,"padj":0.82161,"ES":0.94516,"NES":1.19991,"nMoreExtreme":13360,"size":10,"leadingEdge":["CDC42EP2","CDC42"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT_PROTEIN","pval":0.20792,"padj":0.79637,"ES":0.94751,"NES":1.19985,"nMoreExtreme":11871,"size":11,"leadingEdge":["SOCS1","PARP14","SOCS3","PTPN2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELL_KILLING","pval":0.19178,"padj":0.79001,"ES":0.79626,"NES":1.19975,"nMoreExtreme":13385,"size":47,"leadingEdge":["P2RX7","IL12RB1","LAG3","HLA-F","HLA-B","HLA-E","HLA-A","HLA-C","BCL2L11","B2M","SLAMF6","STAP1","HLA-G","IL12A","CD226","RASGRP1","PTPRC"]} {"pathway":"GO_HISTONE_H2A_K119_MONOUBIQUITINATION","pval":0.37016,"padj":0.89036,"ES":0.92937,"NES":1.19955,"nMoreExtreme":20395,"size":8,"leadingEdge":["PCGF5","TRIM37"]} {"pathway":"GO_CELL_CELL_ADHESION_MEDIATED_BY_INTEGRIN","pval":0.18166,"padj":0.77668,"ES":0.9465,"NES":1.19938,"nMoreExtreme":10579,"size":13,"leadingEdge":["CCL5","PODXL","WNK1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY","pval":0.21046,"padj":0.79831,"ES":0.94706,"NES":1.19928,"nMoreExtreme":12016,"size":11,"leadingEdge":["PAK1","UBE2I"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION","pval":0.37232,"padj":0.89036,"ES":0.92913,"NES":1.19924,"nMoreExtreme":20514,"size":8,"leadingEdge":["HLA-DOA","HLA-DOB","TAPBPL","LILRB2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS","pval":0.19484,"padj":0.79001,"ES":0.94689,"NES":1.19907,"nMoreExtreme":11238,"size":12,"leadingEdge":["TRIM9","REST"]} {"pathway":"GO_REGULATION_OF_EPITHELIAL_CELL_MIGRATION","pval":0.10138,"padj":0.67298,"ES":0.69077,"NES":1.19905,"nMoreExtreme":8787,"size":191,"leadingEdge":["CD40","CEACAM1","AGT","KLF4","ZC3H12A","P2RX4","ENPP2","EDN1","VEGFC","MIR503","GLIPR2","GLUL","ANXA3","FGF10","STAT5A","DUSP10","SRC","TGFB1","SEMA4A","CCR6","ADGRB1","PTGS2","HAS2","GATA3","NFE2L2","MIR212","PDGFB","SLIT2"]} {"pathway":"GO_ZYMOGEN_INHIBITION","pval":0.37319,"padj":0.89036,"ES":0.92898,"NES":1.19905,"nMoreExtreme":20562,"size":8,"leadingEdge":["CARD16","BIRC3","BIRC7"]} {"pathway":"GO_GOLGI_VESICLE_BUDDING","pval":0.15995,"padj":0.76421,"ES":0.74895,"NES":1.19895,"nMoreExtreme":12033,"size":76,"leadingEdge":["CTSZ","CTSC","NAPA","TRAPPC6A"]} {"pathway":"GO_SYNAPTIC_GROWTH_AT_NEUROMUSCULAR_JUNCTION","pval":0.29525,"padj":0.85603,"ES":0.93851,"NES":1.19876,"nMoreExtreme":16499,"size":9,"leadingEdge":["COLQ","SIX1"]} {"pathway":"GO_PROTEIN_AUTOPROCESSING","pval":0.37455,"padj":0.89036,"ES":0.92876,"NES":1.19876,"nMoreExtreme":20637,"size":8,"leadingEdge":["CASP1","HTRA2"]} {"pathway":"GO_RNA_MODIFICATION","pval":0.11684,"padj":0.70159,"ES":0.70133,"NES":1.19864,"nMoreExtreme":9812,"size":153,"leadingEdge":["APOBEC3D","APOBEC3A","APOBEC3G","APOBEC3F","ADAR","SEPHS2","BMT2"]} {"pathway":"GO_MONOCYTE_ACTIVATION","pval":0.37517,"padj":0.89036,"ES":0.92864,"NES":1.19861,"nMoreExtreme":20671,"size":8,"leadingEdge":["DYSF","CSF1","MT1G","HYAL2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION","pval":0.27278,"padj":0.83739,"ES":0.88934,"NES":1.19847,"nMoreExtreme":17162,"size":23,"leadingEdge":["CD274","PDCD1LG2","ZC3H12A","LILRB1","GAS6","GATA3","IL33","TLR4"]} {"pathway":"GO_PROTEIN_O_LINKED_GLYCOSYLATION","pval":0.15599,"padj":0.75836,"ES":0.74142,"NES":1.19826,"nMoreExtreme":11897,"size":83,"leadingEdge":["IL15","MUC1","TMTC1","GCNT3","B4GALT5","TMTC2","GALNT12","ST6GALNAC2","SLC35C2","GALNT3","GCNT1"]} {"pathway":"GO_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION","pval":0.2081,"padj":0.79637,"ES":0.81753,"NES":1.19809,"nMoreExtreme":14134,"size":39,"leadingEdge":["P2RX7","ANO4","ABCB1","XKR6","PLSCR4","PLSCR1","XKR8","XKR7","PRELID1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_POSTTRANSCRIPTIONAL_GENE_SILENCING","pval":0.19933,"padj":0.79183,"ES":0.94605,"NES":1.198,"nMoreExtreme":11497,"size":12,"leadingEdge":["ZC3H12A","TGFB1","ELAVL1"]} {"pathway":"GO_OPIOID_RECEPTOR_SIGNALING_PATHWAY","pval":0.47507,"padj":0.91081,"ES":0.91584,"NES":1.19799,"nMoreExtreme":25822,"size":7,"leadingEdge":["OGFR","SYP"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT","pval":0.21657,"padj":0.80167,"ES":0.946,"NES":1.19793,"nMoreExtreme":12365,"size":11,"leadingEdge":["TGFB1","YBX3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_PROLIFERATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS","pval":0.47643,"padj":0.91176,"ES":0.91561,"NES":1.19769,"nMoreExtreme":25896,"size":7,"leadingEdge":["MIR503","PPP1R16B","HMOX1"]} {"pathway":"GO_REGULATION_OF_LIPID_STORAGE","pval":0.21213,"padj":0.79938,"ES":0.82434,"NES":1.19768,"nMoreExtreme":14269,"size":37,"leadingEdge":["C3","ZC3H12A","TTC39B","IL6","TNF","NR1H3","PTPN2","IKBKE","NFKBIA","EHD1"]} {"pathway":"GO_CALMODULIN_DEPENDENT_KINASE_SIGNALING_PATHWAY","pval":0.58727,"padj":0.94167,"ES":0.89567,"NES":1.19766,"nMoreExtreme":31518,"size":6,"leadingEdge":["LRRK2","ZMPSTE24"]} {"pathway":"GO_PROTEIN_AUTO_ADP_RIBOSYLATION","pval":0.21786,"padj":0.80167,"ES":0.94577,"NES":1.19764,"nMoreExtreme":12439,"size":11,"leadingEdge":["PARP10","PARP12","PARP3","PARP11"]} {"pathway":"GO_AMMONIUM_TRANSMEMBRANE_TRANSPORT","pval":0.24776,"padj":0.82387,"ES":0.94336,"NES":1.19763,"nMoreExtreme":13984,"size":10,"leadingEdge":["SLC25A45","SLC22A1","SLC22A16"]} {"pathway":"GO_QUATERNARY_AMMONIUM_GROUP_TRANSPORT","pval":0.24776,"padj":0.82387,"ES":0.94336,"NES":1.19763,"nMoreExtreme":13984,"size":10,"leadingEdge":["SLC25A45","SLC22A1","SLC22A16"]} {"pathway":"GO_MACROAUTOPHAGY","pval":0.0783,"padj":0.63581,"ES":0.67547,"NES":1.1974,"nMoreExtreme":7135,"size":278,"leadingEdge":["CALCOCO2","LRRK2","ATP13A2","OPTN","RIPK2","RALB","CHMP4C","RUFY4","ATG3","SRC","UVRAG","ATP6V1A","RRAGC","RRAGD","STX17","C9orf72","NPC1","STBD1","LZTS1"]} {"pathway":"GO_REGULATION_OF_PROTEIN_POLYMERIZATION","pval":0.10499,"padj":0.68027,"ES":0.691,"NES":1.19739,"nMoreExtreme":9066,"size":186,"leadingEdge":["SPTBN4","ICAM1","SCIN","TMSB10","ACTR3C","PAK1","CDC42EP2","MAP2","TPPP","AP1AR","SPTA1","SLIT2","MET"]} {"pathway":"GO_T_CELL_SELECTION","pval":0.20921,"padj":0.79637,"ES":0.8169,"NES":1.19717,"nMoreExtreme":14209,"size":39,"leadingEdge":["CD74","IL12RB1","IL15","TBX21","SLAMF6","CYLD","IRF4","IL6","PTPRC","STAT3","PTPN2","GATA3"]} {"pathway":"GO_FAT_PAD_DEVELOPMENT","pval":0.47917,"padj":0.91524,"ES":0.91516,"NES":1.1971,"nMoreExtreme":26045,"size":7,"leadingEdge":["DGAT2","ARID5B","CASR"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_METANEPHROS_DEVELOPMENT","pval":0.5874,"padj":0.94167,"ES":0.89522,"NES":1.19707,"nMoreExtreme":31525,"size":6,"leadingEdge":["STAT1","HNF1B"]} {"pathway":"GO_RESPONSE_TO_ARSENIC_CONTAINING_SUBSTANCE","pval":0.2377,"padj":0.82177,"ES":0.85677,"NES":1.19699,"nMoreExtreme":15424,"size":29,"leadingEdge":["ATF3","CYP1A1","ZC3H12A","GCLC","CDKN1A"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY","pval":0.2038,"padj":0.79626,"ES":0.94521,"NES":1.19694,"nMoreExtreme":11755,"size":12,"leadingEdge":["HLA-F","CEACAM1","HLA-E","HLA-G","SERPINB9","LILRB1","CLEC12B"]} {"pathway":"GO_REGULATION_OF_AUTOPHAGOSOME_MATURATION","pval":0.2515,"padj":0.8268,"ES":0.9428,"NES":1.19691,"nMoreExtreme":14195,"size":10,"leadingEdge":["CALCOCO2","UVRAG","CLEC16A"]} {"pathway":"GO_ADIPONECTIN_SECRETION","pval":0.58744,"padj":0.94167,"ES":0.8951,"NES":1.19691,"nMoreExtreme":31527,"size":6,"leadingEdge":["HCAR2","RAB11FIP3"]} {"pathway":"GO_PSEUDOPODIUM_ORGANIZATION","pval":0.20415,"padj":0.79637,"ES":0.94515,"NES":1.19686,"nMoreExtreme":11775,"size":12,"leadingEdge":["CDC42EP2","CDC42"]} {"pathway":"GO_INTRACELLULAR_STEROL_TRANSPORT","pval":0.26487,"padj":0.83566,"ES":0.91269,"NES":1.19679,"nMoreExtreme":16267,"size":19,"leadingEdge":["CES1","NPC1","SYT7"]} {"pathway":"GO_ESTABLISHMENT_OF_VIRAL_LATENCY","pval":0.3066,"padj":0.86306,"ES":0.9369,"NES":1.19671,"nMoreExtreme":17133,"size":9,"leadingEdge":["IRF7","LIG4","XRCC5"]} {"pathway":"GO_PRO_B_CELL_DIFFERENTIATION","pval":0.30694,"padj":0.86308,"ES":0.93684,"NES":1.19663,"nMoreExtreme":17152,"size":9,"leadingEdge":["LIG4","HES1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_3_SIGNALING_PATHWAY","pval":0.48175,"padj":0.91676,"ES":0.91477,"NES":1.19659,"nMoreExtreme":26185,"size":7,"leadingEdge":["WDFY1","FLOT1","CAV1"]} {"pathway":"GO_STRIATED_MUSCLE_CONTRACTION","pval":0.13333,"padj":0.72971,"ES":0.71174,"NES":1.19616,"nMoreExtreme":10843,"size":124,"leadingEdge":["PDE4B","KCNJ2","CAMK2D","SRI","ZC3H12A","P2RX4","ANK2","KCNE5","MYH7","RNF207","STAC3","SLC8A1","KCNE1","CLIC2","RCSD1","KCNE1B","ARHGEF11","MYBPH"]} {"pathway":"GO_CELLULAR_COPPER_ION_HOMEOSTASIS","pval":0.19497,"padj":0.79001,"ES":0.94394,"NES":1.19614,"nMoreExtreme":11354,"size":13,"leadingEdge":["SLC31A2","SCO2","MT2A","SLC31A1"]} {"pathway":"GO_CERAMIDE_TRANSPORT","pval":0.31005,"padj":0.86489,"ES":0.93639,"NES":1.19606,"nMoreExtreme":17326,"size":9,"leadingEdge":["ABCB1","GLTPD2","PLTP"]} {"pathway":"GO_INTERMEMBRANE_LIPID_TRANSFER","pval":0.31005,"padj":0.86489,"ES":0.93639,"NES":1.19606,"nMoreExtreme":17326,"size":9,"leadingEdge":["GRAMD1B","GLTPD2","GRAMD1A"]} {"pathway":"GO_VASODILATION","pval":0.25438,"padj":0.82744,"ES":0.87116,"NES":1.19605,"nMoreExtreme":16275,"size":26,"leadingEdge":["GCH1","AGT","SOD2","KCNMA1","GUCY1A1","ADORA2A"]} {"pathway":"GO_REGULATION_OF_NIK_NF_KAPPAB_SIGNALING","pval":0.15301,"padj":0.75292,"ES":0.73323,"NES":1.19601,"nMoreExtreme":11829,"size":91,"leadingEdge":["NOD2","ZC3H12A","CYLD","EDN1","LITAF","TLR7","TLR3","TNF","RBCK1","CHI3L1","CCL19","PRDX1","NFKBIA","TCIM","TLR4"]} {"pathway":"GO_MONONUCLEAR_CELL_MIGRATION","pval":0.17209,"padj":0.77295,"ES":0.75953,"NES":1.196,"nMoreExtreme":12660,"size":66,"leadingEdge":["CXCL10","CCL13","CCL7","CCL15","CCL8","SLAMF8","CCL18","CCL5","LYN","CSF1","IL6","TNF","FLT1","CD47","CCL1","CXCL12","CCL4","FPR2","CCL2","TGFB1","CCL19","CCL3","CX3CL1","PLCB1","PDGFB","SLIT2"]} {"pathway":"GO_PROTEIN_POLYMERIZATION","pval":0.08852,"padj":0.65704,"ES":0.67938,"NES":1.19598,"nMoreExtreme":7927,"size":243,"leadingEdge":["PSTPIP2","MSRB1","JAK2","SPTBN4","ICAM1","SCIN","TMSB10","FAM107A","MX1","ACTR3C","PAK1","CDC42EP2","MAP2","TPPP","AP1AR","SPTA1","SLIT2","COBL","MET"]} {"pathway":"GO_RESPONSE_TO_INTERLEUKIN_2","pval":0.20906,"padj":0.79637,"ES":0.94431,"NES":1.1958,"nMoreExtreme":12058,"size":12,"leadingEdge":["JAK3","IL2RG","STAT5A","PTPN2","IL2RA"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERASE","pval":0.26995,"padj":0.83739,"ES":0.91189,"NES":1.19574,"nMoreExtreme":16579,"size":19,"leadingEdge":["XRN1","SRC","STN1","HNRNPC"]} {"pathway":"GO_REGULATION_OF_RAC_PROTEIN_SIGNAL_TRANSDUCTION","pval":0.19673,"padj":0.791,"ES":0.94363,"NES":1.19574,"nMoreExtreme":11457,"size":13,"leadingEdge":["RASGRF1","AUTS2","STMN3","ALS2"]} {"pathway":"GO_REGULATION_OF_PHOSPHOLIPASE_ACTIVITY","pval":0.18586,"padj":0.77996,"ES":0.77867,"NES":1.19534,"nMoreExtreme":13229,"size":54,"leadingEdge":["ITK","AGT","CCL5","FLT1","PTAFR","P2RY12","PDGFRA","LPAR1","EDNRA"]} {"pathway":"GO_INTERLEUKIN_35_MEDIATED_SIGNALING_PATHWAY","pval":0.22827,"padj":0.81508,"ES":0.94392,"NES":1.19529,"nMoreExtreme":13033,"size":11,"leadingEdge":["STAT1","JAK2","IL12RB2","IL12A","EBI3","STAT3","STAT4"]} {"pathway":"GO_SYNAPTIC_VESICLE_CYTOSKELETAL_TRANSPORT","pval":0.25476,"padj":0.82751,"ES":0.91775,"NES":1.19524,"nMoreExtreme":15499,"size":18,"leadingEdge":["DTNBP1","MAP2","TRIM46","AP3D1"]} {"pathway":"GO_IMMUNOLOGICAL_SYNAPSE_FORMATION","pval":0.22862,"padj":0.81508,"ES":0.94386,"NES":1.19522,"nMoreExtreme":13053,"size":11,"leadingEdge":["CCL19","CD6"]} {"pathway":"GO_RESPONSE_TO_LIPID","pval":0.02036,"padj":0.36159,"ES":0.65552,"NES":1.19521,"nMoreExtreme":2006,"size":710,"leadingEdge":["IL18BP","IDO1","CD40","P2RX7","CD274","GCH1","CXCL11","CD38","PDCD1LG2","IL15","PDE4B","CXCL10","NOD2","ACOD1","CXCL9","SSTR2","PADI2","JAK2","AGT","PIM1","RIPK2","ACSL1","XRN1","VCAM1","CYP1A1","ICAM1","PAQR8","KLF4","BCL2L11","CD80","CSF2RB","ZC3H12A","CARD17","STAP1","CARD16","IL12RB2","GRAMD1B","EDN1","IGF2R","FAM107A","LILRA2","IL1RN","SBNO2","DGAT2","PTGER4","CMPK2","LITAF","CCL5","LYN","IL12A","TICAM2","LTA","EPHX1","NR4A3","PLSCR4","PTPRU","TNFAIP3","ANXA3","IL6","FGF10","NFKB2","TNF","PTGER2","DUSP10","CD86","HNF4G","CCR5","NCOA1","ASCL1","CYP27B1","PTAFR","NR1H3","NR4A2","LILRB1","CCL2","KMO","STAT3","PAK1","RUNX1","SRC","TGFB1","CCL19","CXCL8","CDKN1A","AKIRIN2","UCP2","TXNIP","NFKBIA","LPAR1","CREBRF","PTGS2","PLPP1","CCL3","CX3CL1","TRIM25","CFLAR","RGS9","CASP1","NKX3-1","PPARGC1B"]} {"pathway":"GO_REGULATION_OF_CAVEOLIN_MEDIATED_ENDOCYTOSIS","pval":0.53566,"padj":0.92816,"ES":0.83926,"NES":1.19514,"nMoreExtreme":27878,"size":4,"leadingEdge":["SRC","NEDD4L"]} {"pathway":"GO_REGULATION_OF_AUTOPHAGY_OF_MITOCHONDRION_IN_RESPONSE_TO_MITOCHONDRIAL_DEPOLARIZATION","pval":0.2038,"padj":0.79626,"ES":0.93904,"NES":1.19502,"nMoreExtreme":11995,"size":14,"leadingEdge":["OPTN","MUL1"]} {"pathway":"GO_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY","pval":0.05953,"padj":0.58367,"ES":0.66518,"NES":1.195,"nMoreExtreme":5620,"size":377,"leadingEdge":["GBP5","AIM2","PLEK","SPTBN4","ICAM1","BCL2L11","PRRT2","MEFV","SCIN","RALB","TMSB10","PMAIP1","PTGER4","TRABD2A","TNF","FARP2","ACTR3C","P2RY12","PAK1","TRIM9","SRC","TGFB1","CDC42EP2","MAP2","TPPP","AP1AR","NAPA","SPTA1","SLIT2"]} {"pathway":"GO_AROMATIC_AMINO_ACID_FAMILY_CATABOLIC_PROCESS","pval":0.21301,"padj":0.7999,"ES":0.94358,"NES":1.19487,"nMoreExtreme":12286,"size":12,"leadingEdge":["IDO1","IDO2","KYNU","KMO","HPD"]} {"pathway":"GO_RESPONSE_TO_INCREASED_OXYGEN_LEVELS","pval":0.27727,"padj":0.84047,"ES":0.88667,"NES":1.19487,"nMoreExtreme":17444,"size":23,"leadingEdge":["FAS","CYP1A1","POLB","CDKN1A","ATP6V1A"]} {"pathway":"GO_CHONDROCYTE_PROLIFERATION","pval":0.26202,"padj":0.83196,"ES":0.9411,"NES":1.19476,"nMoreExtreme":14789,"size":10,"leadingEdge":["COMP","CCN2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ATPASE_ACTIVITY","pval":0.20075,"padj":0.7919,"ES":0.94284,"NES":1.19475,"nMoreExtreme":11691,"size":13,"leadingEdge":["SNX16","VCPKMT"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION","pval":0.06254,"padj":0.59455,"ES":0.666,"NES":1.19473,"nMoreExtreme":5883,"size":364,"leadingEdge":["AIM2","P2RX7","CD274","LRRK2","CD38","NOD2","CLEC9A","ATP13A2","HLA-E","HCAR2","JAK2","RIPK2","TLR8","CLEC6A","GSDMD","SRI","ZC3H12A","VEGFC","IFIH1","PMAIP1","LILRA2","PTGER4","GLUL","TNFRSF14","EDEM1","IL6","CLEC4E","TNF","RASGRP1","CCL1","DDX58","PAK1","SRC","TGFB1","CCL19","PTGS2","GAS6","CCL3","GATA3","CASP1","IL33","BBC3","NADK","SMAD3","IL1A","STOM","PRR5L"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MEIOTIC_NUCLEAR_DIVISION","pval":0.39664,"padj":0.89503,"ES":0.92555,"NES":1.19462,"nMoreExtreme":21854,"size":8,"leadingEdge":["NPM2","PLCB1","SIRT2"]} {"pathway":"GO_RETROGRADE_TRANS_SYNAPTIC_SIGNALING","pval":0.39664,"padj":0.89503,"ES":0.92555,"NES":1.19462,"nMoreExtreme":21854,"size":8,"leadingEdge":["GUCY1A1","PLCB1","NOS1"]} {"pathway":"GO_HUMORAL_IMMUNE_RESPONSE_MEDIATED_BY_CIRCULATING_IMMUNOGLOBULIN","pval":0.24052,"padj":0.82313,"ES":0.85496,"NES":1.19446,"nMoreExtreme":15607,"size":29,"leadingEdge":["C4A","C4B","SERPING1","C1QB","HLA-DQB1","C2","C3","C1S","C1RL","C1R","LTA","TNF","PTPRC","C1QC"]} {"pathway":"GO_REGULATION_OF_DENDRITIC_CELL_DIFFERENTIATION","pval":0.23243,"padj":0.81508,"ES":0.94323,"NES":1.19443,"nMoreExtreme":13271,"size":11,"leadingEdge":["TMEM176A","TMEM176B","HLA-G","LILRB1","LILRB2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_LIPASE_ACTIVITY","pval":0.19136,"padj":0.79001,"ES":0.78384,"NES":1.19438,"nMoreExtreme":13518,"size":51,"leadingEdge":["ITK","AGT","CCL5","FLT1","PTAFR","NR1H3","P2RY12","PDGFRA","LPAR1","LMF1","EDNRA"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES","pval":0.12803,"padj":0.72213,"ES":0.70404,"NES":1.19429,"nMoreExtreme":10596,"size":139,"leadingEdge":["IL18BP","LRRK2","GCH1","HGF","KLF4","NCF1","NR4A3","SOD2","TNFAIP3","IL6","TXN","TNF","SMPD3","SRC","PRDX1","PDGFRA","NME8","GUCY1B1","CFLAR","NFE2L2","PPARGC1B"]} {"pathway":"GO_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN","pval":0.11143,"padj":0.69864,"ES":0.69065,"NES":1.19426,"nMoreExtreme":9580,"size":180,"leadingEdge":["FBXO6","ATF3","OPTN","BCL2L11","COMP","CHAC1","EDEM1","CCL2","PTPN2","CXCL8","PTPN1","CREBRF","ASNS","NFE2L2","HERPUD1","BAK1"]} {"pathway":"GO_REGULATION_OF_CELL_SHAPE","pval":0.13067,"padj":0.72638,"ES":0.70591,"NES":1.1942,"nMoreExtreme":10753,"size":134,"leadingEdge":["CCL13","ITGA7","CCL7","ICAM1","S100A13","RHOBTB3","RND1","PLEKHO1","HPN","FGD2","RHOH","CCL2","SEMA4A","CDC42EP2","RHOQ","LPAR1","CCL3","SEMA4D","FGD6","CDC42SE2","SPTA1"]} {"pathway":"GO_REGULATION_OF_HAIR_CYCLE","pval":0.27775,"padj":0.84047,"ES":0.91041,"NES":1.1938,"nMoreExtreme":17058,"size":19,"leadingEdge":["TNF","FST","CDH3"]} {"pathway":"GO_REGULATION_OF_NEUROTROPHIN_TRK_RECEPTOR_SIGNALING_PATHWAY","pval":0.21838,"padj":0.80167,"ES":0.94257,"NES":1.19359,"nMoreExtreme":12596,"size":12,"leadingEdge":["AGT","CYFIP2"]} {"pathway":"GO_NUCLEOSIDE_DIPHOSPHATE_CATABOLIC_PROCESS","pval":0.49851,"padj":0.91907,"ES":0.91247,"NES":1.19358,"nMoreExtreme":27096,"size":7,"leadingEdge":["ENTPD2","NUDT5"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_MAGNESIUM_ION","pval":0.58863,"padj":0.94167,"ES":0.89247,"NES":1.19339,"nMoreExtreme":31591,"size":6,"leadingEdge":["SMPD3","KCNA1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TRANSPORT","pval":0.01853,"padj":0.35375,"ES":0.6539,"NES":1.19333,"nMoreExtreme":1830,"size":759,"leadingEdge":["ATP1B2","IL15RA","AIM2","C4A","P2RX7","CD274","LRRK2","CXCL11","C4B","CD38","IL15","CXCL10","NOD2","HLA-F","CLEC9A","ATP13A2","HLA-E","CXCL9","HCAR2","JAK2","AGT","RIPK2","TLR8","C2","KCNJ2","CLEC6A","GSDMD","SRI","B2M","C3","CD300LF","ZC3H12A","ABCB1","CTSS","P2RX4","STAP1","SCIN","NPR1","EDN1","VEGFC","IFIH1","PMAIP1","LILRA2","ANK2","PTGER4","CCL5","DTNBP1","GLUL","SYNGR3","CADPS2","NR4A3","TNFRSF14","KCNE5","EDEM1","RNF207","STAC3","IL6","CLEC4E","IL2RG","TNF","CD47","RASGRP1","CAMK1D","AZIN2","SMPD3","CCL1","CXCL12","PTPRC","LIPG","PTAFR","DDX58","CCL4","NR1H3","KCNE1","CCL2","KMO","CACNA1I","P2RY12","PAK1","SRC","TGFB1","CCL19","P2RY2","RHOQ","NFKBIA","ACTN2","MAP2","PTGS2","GAS6","CCL3","CX3CL1","PRELID1","RGS9","GATA3","CASP1","NKX3-1","NFE2L2","IL33","BBC3","NADK","PDGFB","SMAD3","ILDR1","GLRX","BAK1","IL1A","STOM","PRR5L","FCER1G","TRIM46","LILRA5","S100A1","FLOT1","ARC","TLR4","CCR1","KCNMB1","RUFY3"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_ZINC_ION","pval":0.2276,"padj":0.81464,"ES":0.92889,"NES":1.19331,"nMoreExtreme":13633,"size":16,"leadingEdge":["ATP13A2","P2RX4","MT2A","MT1M","MT1E","MT1H","HVCN1","MT1G"]} {"pathway":"GO_RESPONSE_TO_CHEMOKINE","pval":0.17332,"padj":0.77508,"ES":0.75253,"NES":1.19323,"nMoreExtreme":12870,"size":70,"leadingEdge":["CXCL11","CXCL10","CCL13","CXCL9","PADI2","CCL7","CCL15","CCL8","ZC3H12A","CCRL2","EDN1","CCL18","CCL5","CCR5","CCL1","CXCL12","CCL4","ACKR4","CCL2","ROBO1","CCL19","CCR6","CXCL8","RIPOR2","CCL3","CX3CL1","FOXC1"]} {"pathway":"GO_REGULATION_OF_HYALURONAN_BIOSYNTHETIC_PROCESS","pval":0.40527,"padj":0.89503,"ES":0.92443,"NES":1.19317,"nMoreExtreme":22330,"size":8,"leadingEdge":["SMPD3","TGFB1","HAS2","PDGFB"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_INCREASED_OXYGEN_LEVELS","pval":0.20781,"padj":0.79637,"ES":0.94155,"NES":1.19311,"nMoreExtreme":12102,"size":13,"leadingEdge":["FAS","ATP6V1A","ATP6AP1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELL_PROLIFERATION_INVOLVED_IN_KIDNEY_DEVELOPMENT","pval":0.4058,"padj":0.89503,"ES":0.92437,"NES":1.1931,"nMoreExtreme":22359,"size":8,"leadingEdge":["CFLAR","LIN28A","PDGFB","EGR1"]} {"pathway":"GO_PHENOTYPIC_SWITCHING","pval":0.40631,"padj":0.89503,"ES":0.92432,"NES":1.19303,"nMoreExtreme":22387,"size":8,"leadingEdge":["SOD2","PDGFB","FGF9"]} {"pathway":"GO_METANEPHRIC_GLOMERULUS_VASCULATURE_DEVELOPMENT","pval":0.40631,"padj":0.89503,"ES":0.92432,"NES":1.19303,"nMoreExtreme":22387,"size":8,"leadingEdge":["PDGFRA","PDGFB","PDGFRB"]} {"pathway":"GO_POSITIVE_REGULATION_OF_GLOMERULUS_DEVELOPMENT","pval":0.40631,"padj":0.89503,"ES":0.92432,"NES":1.19303,"nMoreExtreme":22387,"size":8,"leadingEdge":["CFLAR","PDGFB","EGR1"]} {"pathway":"GO_REGULATION_OF_PHENOTYPIC_SWITCHING","pval":0.40631,"padj":0.89503,"ES":0.92432,"NES":1.19303,"nMoreExtreme":22387,"size":8,"leadingEdge":["SOD2","PDGFB","FGF9"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ION_TRANSMEMBRANE_TRANSPORT","pval":0.1453,"padj":0.74662,"ES":0.71624,"NES":1.19297,"nMoreExtreme":11635,"size":112,"leadingEdge":["ATP1B2","P2RX7","CXCL11","CXCL10","CXCL9","AGT","KCNJ2","SRI","ABCB1","CTSS","ANK2","KCNE5","RNF207","STAC3","PTAFR","KCNE1","ACTN2","CX3CL1","RGS9","GLRX","S100A1","ARC","KCNMB1"]} {"pathway":"GO_LOCOMOTORY_EXPLORATION_BEHAVIOR","pval":0.27145,"padj":0.83739,"ES":0.93966,"NES":1.19293,"nMoreExtreme":15321,"size":10,"leadingEdge":["LRRK2","SLC4A10"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_LAMINAR_FLUID_SHEAR_STRESS","pval":0.50237,"padj":0.91978,"ES":0.91196,"NES":1.19292,"nMoreExtreme":27306,"size":7,"leadingEdge":["KLF4","NFE2L2","ASS1"]} {"pathway":"GO_BILE_ACID_METABOLIC_PROCESS","pval":0.23853,"padj":0.82177,"ES":0.84933,"NES":1.19288,"nMoreExtreme":15549,"size":30,"leadingEdge":["HSD3B7","OSBPL6","CH25H","NPC1","PROX1","NR5A2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_REGULATORY_T_CELL_DIFFERENTIATION","pval":0.24019,"padj":0.82313,"ES":0.94199,"NES":1.19286,"nMoreExtreme":13714,"size":11,"leadingEdge":["SOCS1","BTN2A2","HLA-G","BCL6","LILRB4","DUSP10","TGFB1","LILRB2"]} {"pathway":"GO_SUCCINATE_METABOLIC_PROCESS","pval":0.50285,"padj":0.91978,"ES":0.91191,"NES":1.19284,"nMoreExtreme":27332,"size":7,"leadingEdge":["SDHB","SDHA"]} {"pathway":"GO_KERATAN_SULFATE_CATABOLIC_PROCESS","pval":0.40743,"padj":0.89503,"ES":0.92415,"NES":1.19281,"nMoreExtreme":22449,"size":8,"leadingEdge":["GNS","HEXB"]} {"pathway":"GO_CHAPERONE_MEDIATED_PROTEIN_COMPLEX_ASSEMBLY","pval":0.26663,"padj":0.83635,"ES":0.91584,"NES":1.19275,"nMoreExtreme":16221,"size":18,"leadingEdge":["HOPX","PTGES3L","HSP90AA1"]} {"pathway":"GO_DENDRITIC_CELL_APOPTOTIC_PROCESS","pval":0.32925,"padj":0.87227,"ES":0.93358,"NES":1.19247,"nMoreExtreme":18399,"size":9,"leadingEdge":["RAPGEF2","LYN","CXCL12","LILRB1","CCL19","GAS6"]} {"pathway":"GO_FAT_CELL_DIFFERENTIATION","pval":0.11395,"padj":0.69895,"ES":0.68987,"NES":1.19237,"nMoreExtreme":9789,"size":179,"leadingEdge":["SOCS1","EGR2","STEAP4","PSMB8","KLF4","ZC3H12A","ATF5","DYSF","NR4A3","IL6","FGF10","TNF","SOX8","DUSP10","NR4A2","SH2B2","TGFB1","SORT1","PTGS2","GATA3","ERAP1","PLCB1","SMAD3","ZFP36","ARID5B","PLAC8","FABP4","WNT1"]} {"pathway":"GO_TETRAPYRROLE_METABOLIC_PROCESS","pval":0.28033,"padj":0.84253,"ES":0.88477,"NES":1.19231,"nMoreExtreme":17637,"size":23,"leadingEdge":["CYP1A1","TCN2","MMAA","AMN","FECH"]} {"pathway":"GO_NUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS","pval":0.19559,"padj":0.79001,"ES":0.78483,"NES":1.19227,"nMoreExtreme":13757,"size":50,"leadingEdge":["LRRK2","GIMAP7","GTPBP1","CTNS","MYH7","SLC25A25","ATP6V1A","RHOQ","AK4","NADK"]} {"pathway":"GO_CELLULAR_MACROMOLECULE_CATABOLIC_PROCESS","pval":0.00704,"padj":0.21983,"ES":0.65153,"NES":1.19224,"nMoreExtreme":700,"size":1040,"leadingEdge":["UBD","PSME2","LRRK2","PSMB9","FBXO6","LAMP3","TBX21","ATP13A2","PSME1","ISG20","PSMB10","NUB1","IFI27","UBE2L6","PSMB8","XRN1","SIDT2","SAMD4A","PML","RNF19B","ZC3H12A","CTSS","CYLD","CTSO","GTPBP1","DTX3L","PMAIP1","CHMP4C","OAS2","PYHIN1","CTSL","AMER1","TNFAIP3","EDEM1","RNF144B","MYD88","CTSZ","PSMA4","PSMA2","SPOPL","RBCK1","CUL1","TRIM72","HELZ2","MOV10","UBE2A","TRIM71","TRIM9","GCLC","PSMA5","CTSC","UBE2Z","ISG15","USP18","TRIM25","ERLIN1","NFE2L2","IL33","LIN28A","HERPUD1","ERI1","ZFP36","SCPEP1","PRR5L","NUPR1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MITOPHAGY","pval":0.2755,"padj":0.8385,"ES":0.93904,"NES":1.19214,"nMoreExtreme":15550,"size":10,"leadingEdge":["OPTN","VPS13D"]} {"pathway":"GO_NEUTROPHIL_MIGRATION","pval":0.15911,"padj":0.76421,"ES":0.73167,"NES":1.19213,"nMoreExtreme":12280,"size":90,"leadingEdge":["CD74","CXCL11","PDE4B","CXCL10","CCL13","CXCL9","CCL7","MCOLN2","CCL15","CCL8","EDN1","IL1RN","DYSF","SLAMF8","CCL18","CCL5","CAMK1D","CCL1","CCL4","CCL2","CCL19","CXCL8","RIPOR2","CCL3","CX3CL1","DAPK2","SLIT2","FCER1G"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_SECRETION","pval":0.24877,"padj":0.82387,"ES":0.85782,"NES":1.1921,"nMoreExtreme":16069,"size":28,"leadingEdge":["AIM2","P2RX7","NOD2","RIPK2","TLR8","GSDMD","LILRA2","CCL19","CCL3","CASP1","LILRA5","TLR4","PANX2"]} {"pathway":"GO_INTERLEUKIN_8_BIOSYNTHETIC_PROCESS","pval":0.33131,"padj":0.87332,"ES":0.93329,"NES":1.19209,"nMoreExtreme":18514,"size":9,"leadingEdge":["TLR8","KLF4","TLR7","TNF","TLR4"]} {"pathway":"GO_REGULATION_OF_CD8_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION","pval":0.21758,"padj":0.80167,"ES":0.93671,"NES":1.19206,"nMoreExtreme":12806,"size":14,"leadingEdge":["IRF1","SOCS1","CD274","HLA-E","LILRB1","RUNX1","SH3RF1"]} {"pathway":"GO_MORPHOGENESIS_OF_AN_ENDOTHELIUM","pval":0.21823,"padj":0.80167,"ES":0.9366,"NES":1.19191,"nMoreExtreme":12844,"size":14,"leadingEdge":["CXCL10","RHOA"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TYPE_I_INTERFERON_MEDIATED_SIGNALING_PATHWAY","pval":0.21409,"padj":0.7999,"ES":0.94037,"NES":1.19161,"nMoreExtreme":12468,"size":13,"leadingEdge":["NLRC5","ZBP1","IRF7","IKBKE"]} {"pathway":"GO_RETINOIC_ACID_METABOLIC_PROCESS","pval":0.50951,"padj":0.92379,"ES":0.91095,"NES":1.19159,"nMoreExtreme":27694,"size":7,"leadingEdge":["SCPEP1","ALDH1A2","CRABP2"]} {"pathway":"GO_AMINO_SUGAR_BIOSYNTHETIC_PROCESS","pval":0.21444,"padj":0.7999,"ES":0.94031,"NES":1.19154,"nMoreExtreme":12488,"size":13,"leadingEdge":["NAGK","PGM3"]} {"pathway":"GO_REGULATION_OF_PROTEIN_SUMOYLATION","pval":0.29909,"padj":0.85717,"ES":0.90251,"NES":1.1915,"nMoreExtreme":18487,"size":20,"leadingEdge":["HDAC4","MAGEA2","PIAS1"]} {"pathway":"GO_GLYCOLIPID_CATABOLIC_PROCESS","pval":0.21524,"padj":0.80139,"ES":0.94015,"NES":1.19133,"nMoreExtreme":12535,"size":13,"leadingEdge":["GM2A","HEXB"]} {"pathway":"GO_ASPARTATE_FAMILY_AMINO_ACID_METABOLIC_PROCESS","pval":0.2142,"padj":0.7999,"ES":0.81,"NES":1.19122,"nMoreExtreme":14600,"size":40,"leadingEdge":["SDSL","ASNS","ASS1","MTHFR","SDS","AASS"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_ATP","pval":0.23824,"padj":0.82177,"ES":0.9271,"NES":1.19101,"nMoreExtreme":14270,"size":16,"leadingEdge":["P2RX7","P2RX4","P2RY12","P2RY2","PTGS2"]} {"pathway":"GO_MIRNA_MEDIATED_INHIBITION_OF_TRANSLATION","pval":0.25616,"padj":0.82758,"ES":0.92091,"NES":1.19094,"nMoreExtreme":15479,"size":17,"leadingEdge":["MIR503","STAT3","TRIM71","MIR212","ZFP36"]} {"pathway":"GO_UDP_N_ACETYLGLUCOSAMINE_BIOSYNTHETIC_PROCESS","pval":0.25033,"padj":0.82482,"ES":0.94032,"NES":1.19074,"nMoreExtreme":14293,"size":11,"leadingEdge":["NAGK","PGM3"]} {"pathway":"GO_T_HELPER_2_CELL_CYTOKINE_PRODUCTION","pval":0.33942,"padj":0.87818,"ES":0.93212,"NES":1.19059,"nMoreExtreme":18967,"size":9,"leadingEdge":["IL31RA","TBX21","RSAD2","DENND1B","IL6","GATA3"]} {"pathway":"GO_OLIGOSACCHARIDE_CATABOLIC_PROCESS","pval":0.25116,"padj":0.82605,"ES":0.94015,"NES":1.19053,"nMoreExtreme":14340,"size":11,"leadingEdge":["GM2A","MAN2B2"]} {"pathway":"GO_PHAGOSOME_LYSOSOME_FUSION","pval":0.41994,"padj":0.89612,"ES":0.92229,"NES":1.19042,"nMoreExtreme":23138,"size":8,"leadingEdge":["RAB20","RAB39A","SYT7"]} {"pathway":"GO_SENSORY_PERCEPTION_OF_PAIN","pval":0.18339,"padj":0.77986,"ES":0.76195,"NES":1.19029,"nMoreExtreme":13356,"size":62,"leadingEdge":["P2RX7","P2RX4","EDN1","SCN9A","CXCL12","PTAFR","CCL2","PTGS2","CCL3","ACPP"]} {"pathway":"GO_REGULATION_OF_ARP2_3_COMPLEX_MEDIATED_ACTIN_NUCLEATION","pval":0.23279,"padj":0.81532,"ES":0.93131,"NES":1.18988,"nMoreExtreme":13832,"size":15,"leadingEdge":["AP1AR","WAS"]} {"pathway":"GO_SUSCEPTIBILITY_TO_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY","pval":0.42271,"padj":0.89612,"ES":0.92185,"NES":1.18984,"nMoreExtreme":23291,"size":8,"leadingEdge":["MICB","PVR"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PHOSPHOLIPID_TRANSPORT","pval":0.34393,"padj":0.88094,"ES":0.93151,"NES":1.18982,"nMoreExtreme":19219,"size":9,"leadingEdge":["PRELID1","ABCB4"]} {"pathway":"GO_ELECTRON_TRANSPORT_CHAIN","pval":0.12802,"padj":0.72213,"ES":0.69679,"NES":1.18973,"nMoreExtreme":10729,"size":151,"leadingEdge":["IDO1","STEAP4","AIFM2","C15orf48","NCF1","SLC25A22","GPD2","NCF2","GLRX","SDHB"]} {"pathway":"GO_SEMICIRCULAR_CANAL_MORPHOGENESIS","pval":0.5204,"padj":0.9256,"ES":0.90943,"NES":1.18961,"nMoreExtreme":28286,"size":7,"leadingEdge":["NR4A3","FGF10","TBX1"]} {"pathway":"GO_NEUROMUSCULAR_JUNCTION_DEVELOPMENT","pval":0.20901,"padj":0.79637,"ES":0.79729,"NES":1.18956,"nMoreExtreme":14460,"size":44,"leadingEdge":["LRRK2","COLQ","PTN","SIX1","ALS2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_NEUROINFLAMMATORY_RESPONSE","pval":0.52095,"padj":0.9256,"ES":0.90938,"NES":1.18954,"nMoreExtreme":28316,"size":7,"leadingEdge":["PTPRC","CX3CL1","IGF1"]} {"pathway":"GO_REGULATION_OF_LIPID_METABOLIC_PROCESS","pval":0.08072,"padj":0.64196,"ES":0.66752,"NES":1.1891,"nMoreExtreme":7448,"size":308,"leadingEdge":["SOCS1","GOLM1","NOD2","CEACAM1","AGT","ACSL1","CYP1A1","KLF4","C3","ALAS1","LACTB","CISH","TTC39B","DGAT2","LYN","NR4A3","TNF","FLT1","HELZ2","SMPD3","NCOA1","CYP27B1","NR1H3","FPR2","SOCS3","P2RY12","ANGPTL4","SRC","TGFB1","CCL19","PDGFRA","PTGS2","PLPP1","ERLIN1","PDGFB","RAB38","LMF1","SIK1","AGAP2","INSIG2","CPT1A","LPGAT1","PROX1","LSR"]} {"pathway":"GO_PROTEIN_PROCESSING","pval":0.12534,"padj":0.71713,"ES":0.69364,"NES":1.189,"nMoreExtreme":10590,"size":159,"leadingEdge":["P2RX7","LRRK2","RIPK2","CTSS","CARD16","C1RL","COMP","C1R","CHAC1","BIRC3","CTSZ","HPN","PSEN2","F3","SRC","PLGRKT","CES1","BIRC7","CASP1","IL1R2","KLK1","BAK1","NGF"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION","pval":0.2475,"padj":0.82387,"ES":0.85094,"NES":1.18885,"nMoreExtreme":16060,"size":29,"leadingEdge":["SOCS1","IL12RB1","RIPK2","CD80","CD83","CD86","CCL19","HLX"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CHEMOKINE_PRODUCTION","pval":0.20542,"padj":0.79637,"ES":0.78876,"NES":1.18846,"nMoreExtreme":14337,"size":47,"leadingEdge":["CD74","RIPK2","MCOLN2","TLR7","IL7","IL6","TLR3","TNF","IL33","TLR4","TICAM1"]} {"pathway":"GO_REGULATION_OF_T_CELL_MEDIATED_CYTOTOXICITY","pval":0.24404,"padj":0.82387,"ES":0.84615,"NES":1.18843,"nMoreExtreme":15908,"size":30,"leadingEdge":["P2RX7","IL12RB1","HLA-F","CEACAM1","HLA-B","HLA-E","HLA-A","HLA-C","B2M","HLA-G","IL12A","PTPRC","LILRB1"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_NUTRIENT","pval":0.18794,"padj":0.78227,"ES":0.7636,"NES":1.18839,"nMoreExtreme":13622,"size":60,"leadingEdge":["P2RX7","IL15","PIM1","P2RX4","NCOA1","CYP27B1","P2RY12","P2RY2","PTGS2","GAS6"]} {"pathway":"GO_BILE_ACID_BIOSYNTHETIC_PROCESS","pval":0.28485,"padj":0.84761,"ES":0.88185,"NES":1.18838,"nMoreExtreme":17921,"size":23,"leadingEdge":["HSD3B7","OSBPL6","CH25H","PROX1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CHOLESTEROL_EFFLUX","pval":0.22974,"padj":0.81508,"ES":0.93778,"NES":1.18834,"nMoreExtreme":13379,"size":13,"leadingEdge":["NR1H3","NFKBIA","ABCA7"]} {"pathway":"GO_INTERLEUKIN_7_MEDIATED_SIGNALING_PATHWAY","pval":0.26889,"padj":0.83693,"ES":0.91884,"NES":1.18827,"nMoreExtreme":16248,"size":17,"leadingEdge":["SOCS1","JAK3","CISH","IL7","IL2RG","STAT5A","STAT3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE","pval":0.26315,"padj":0.83229,"ES":0.9383,"NES":1.18818,"nMoreExtreme":15025,"size":11,"leadingEdge":["PTPN1","HSPA5"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MAST_CELL_ACTIVATION","pval":0.26929,"padj":0.83693,"ES":0.91877,"NES":1.18817,"nMoreExtreme":16272,"size":17,"leadingEdge":["NR4A3","CD226","FCER1G","FGR"]} {"pathway":"GO_SMOOTH_MUSCLE_CELL_CHEMOTAXIS","pval":0.43295,"padj":0.90066,"ES":0.92044,"NES":1.18802,"nMoreExtreme":23855,"size":8,"leadingEdge":["LPAR1","SLIT2","GSTP1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE","pval":0.30222,"padj":0.85863,"ES":0.906,"NES":1.18801,"nMoreExtreme":18561,"size":19,"leadingEdge":["CD74","HLA-G","NR4A3","SEMA7A","DDX58","LILRB1","FCER1G","TLR4","TICAM1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_DELAYED_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY","pval":0.43324,"padj":0.90066,"ES":0.92038,"NES":1.18795,"nMoreExtreme":23871,"size":8,"leadingEdge":["KCNE5","KCNE1","KCNE1B"]} {"pathway":"GO_NEURONAL_ACTION_POTENTIAL","pval":0.31078,"padj":0.86489,"ES":0.89978,"NES":1.18789,"nMoreExtreme":19210,"size":20,"leadingEdge":["P2RX4","SCN9A","CACNA1I","GPR35","KCNMB4","SCN3A","CACNA1G"]} {"pathway":"GO_PHOSPHATIDYLINOSITOL_PHOSPHORYLATION","pval":0.20626,"padj":0.79637,"ES":0.78834,"NES":1.18783,"nMoreExtreme":14395,"size":47,"leadingEdge":["SOCS1","CISH","TMEM150A","SOCS3","PIK3C2A"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_CALCIUM_ION_CONCENTRATION","pval":0.43388,"padj":0.90066,"ES":0.92027,"NES":1.18781,"nMoreExtreme":23906,"size":8,"leadingEdge":["TGM2","BAK1","BAX"]} {"pathway":"GO_POSITIVE_REGULATION_OF_JNK_CASCADE","pval":0.14538,"padj":0.74662,"ES":0.70773,"NES":1.18777,"nMoreExtreme":11794,"size":122,"leadingEdge":["NOD2","RIPK2","EDN1","SLAMF1","NCF1","NRK","IL1RN","GADD45B","TLR3","GADD45G","TNF","RASGRP1","FGD2","PAK1","CCL19","PTPN1","SH3RF1","BIRC7","PLCB1"]} {"pathway":"GO_RECEPTOR_RECYCLING","pval":0.24891,"padj":0.82387,"ES":0.85015,"NES":1.18775,"nMoreExtreme":16152,"size":29,"leadingEdge":["LMTK2","OPTN","AP1AR","ALS2"]} {"pathway":"GO_REGULATION_OF_RENAL_SYSTEM_PROCESS","pval":0.29427,"padj":0.85452,"ES":0.88716,"NES":1.18773,"nMoreExtreme":18412,"size":22,"leadingEdge":["AGT","NPR1","EDN1","GAS6","PDGFB","ADORA2A"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_INTERFERON_ALPHA","pval":0.35541,"padj":0.88844,"ES":0.92988,"NES":1.18773,"nMoreExtreme":19861,"size":9,"leadingEdge":["IFIT3","IFIT2","PYHIN1","GAS6","GATA3","TPR"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TORC1_SIGNALING","pval":0.35541,"padj":0.88844,"ES":0.92988,"NES":1.18773,"nMoreExtreme":19861,"size":9,"leadingEdge":["RRAGD","CLEC16A"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MAST_CELL_ACTIVATION","pval":0.3562,"padj":0.88877,"ES":0.92982,"NES":1.18766,"nMoreExtreme":19905,"size":9,"leadingEdge":["CD300LF","CD84"]} {"pathway":"GO_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS","pval":0.30034,"padj":0.8579,"ES":0.93549,"NES":1.18763,"nMoreExtreme":16952,"size":10,"leadingEdge":["HLA-E","C3","FCER1G","BTK"]} {"pathway":"GO_POSITIVE_REGULATION_OF_VASCULAR_ASSOCIATED_SMOOTH_MUSCLE_CELL_MIGRATION","pval":0.25444,"padj":0.82744,"ES":0.9244,"NES":1.18754,"nMoreExtreme":15241,"size":16,"leadingEdge":["AGT","NR4A3","PAK1","PDGFB"]} {"pathway":"GO_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT","pval":0.05712,"padj":0.57275,"ES":0.65823,"NES":1.1873,"nMoreExtreme":5448,"size":431,"leadingEdge":["IL15RA","C4A","LRRK2","C4B","IL15","HLA-F","CEACAM1","ATP13A2","GRIN3A","C2","PRRT2","B2M","C3","CD300LF","STAP1","RAB20","RALB","DYSF","LYN","DTNBP1","CADPS2","IL2RG","RSC1A1","TNF","CD47","CAMK1D","SMPD3","PTPRC","PTAFR","ATG3","NR1H3","LILRB1","CCL2","CACNA1I","TRIM9","SRC","TGFB1","SYT5","CCL19","PTPN1","ACTN2","MAP2","GAS6","ANKRD13A","DNAJC13","NAPA","SYT17"]} {"pathway":"GO_ESTABLISHMENT_OF_LYMPHOCYTE_POLARITY","pval":0.30234,"padj":0.85863,"ES":0.93515,"NES":1.18721,"nMoreExtreme":17065,"size":10,"leadingEdge":["CCL19","RIPOR2","CYP26B1"]} {"pathway":"GO_PEPTIDYL_GLUTAMIC_ACID_MODIFICATION","pval":0.31277,"padj":0.86489,"ES":0.89919,"NES":1.18712,"nMoreExtreme":19333,"size":20,"leadingEdge":["TTLL7","CFAP20"]} {"pathway":"GO_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS","pval":0.09642,"padj":0.66591,"ES":0.67337,"NES":1.1871,"nMoreExtreme":8669,"size":250,"leadingEdge":["GBP5","IDO1","CD74","LRRK2","IL15","CXCL10","NOD2","HLA-E","ACOD1","OPTN","JAK2","SUCNR1","AGT","RIPK2","CCL7","SCARF1","TGM2","C3","TLR10","P2RX4","STAP1","EDN1","VEGFC","DDX60","DYSF","PTGER4","CCL18","CCL5","IL12A","TLR7","CSF1","LTA","MYD88","IL6","TLR3","FGF10","TNF","CD47","CAMK1D","CCL1","CXCL12","CYP27B1","CCL4","FPR2","F3","P2RY12","DHX58","TGFB1","CCL19","CCR6","CXCL8","NFKBIA","LPAR1","PTGS2","RIPOR2","GAS6","CCL3","CX3CL1","IL33","DAPK2","PDGFB","SMAD3","STX3"]} {"pathway":"GO_UBIQUITIN_DEPENDENT_ERAD_PATHWAY","pval":0.18022,"padj":0.77529,"ES":0.7472,"NES":1.1868,"nMoreExtreme":13412,"size":71,"leadingEdge":["FBXO6","EDEM1","TRIM25","ERLIN1","NFE2L2","HERPUD1","EDEM2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MACROPHAGE_CYTOKINE_PRODUCTION","pval":0.361,"padj":0.89036,"ES":0.92908,"NES":1.18671,"nMoreExtreme":20173,"size":9,"leadingEdge":["CD74","HLA-G","SEMA7A","LILRB1","TLR4"]} {"pathway":"GO_LEARNED_VOCALIZATION_BEHAVIOR_OR_VOCAL_LEARNING","pval":0.53565,"padj":0.92816,"ES":0.90721,"NES":1.18671,"nMoreExtreme":29115,"size":7,"leadingEdge":["TIFAB","NEUROG1"]} {"pathway":"GO_REGULATION_OF_RIBONUCLEASE_ACTIVITY","pval":0.43988,"padj":0.90126,"ES":0.91937,"NES":1.18665,"nMoreExtreme":24237,"size":8,"leadingEdge":["OAS2","OAS3","OASL"]} {"pathway":"GO_RNA_LOCALIZATION","pval":0.10772,"padj":0.68882,"ES":0.67817,"NES":1.18653,"nMoreExtreme":9503,"size":217,"leadingEdge":["SIDT2","MVP","PARP11","ZFP36","FLOT1","ARC","UPF1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_B_CELL_RECEPTOR_SIGNALING_PATHWAY","pval":0.44084,"padj":0.90126,"ES":0.91926,"NES":1.1865,"nMoreExtreme":24290,"size":8,"leadingEdge":["STAP1","LYN","NFAM1","PRKCH"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION","pval":0.19856,"padj":0.79183,"ES":0.77475,"NES":1.18644,"nMoreExtreme":14098,"size":53,"leadingEdge":["LRRK2","CD38","PTGS2","ARC","LILRB2"]} {"pathway":"GO_PREASSEMBLY_OF_GPI_ANCHOR_IN_ER_MEMBRANE","pval":0.27771,"padj":0.84047,"ES":0.91742,"NES":1.18643,"nMoreExtreme":16781,"size":17,"leadingEdge":["PIGY","PIGQ"]} {"pathway":"GO_VIRAL_LATENCY","pval":0.27264,"padj":0.83739,"ES":0.93689,"NES":1.1864,"nMoreExtreme":15567,"size":11,"leadingEdge":["IRF7","LIG4","NUCKS1"]} {"pathway":"GO_APOPTOTIC_PROCESS_INVOLVED_IN_MORPHOGENESIS","pval":0.30932,"padj":0.86471,"ES":0.90471,"NES":1.18632,"nMoreExtreme":18997,"size":19,"leadingEdge":["BCL2L11","FOXC1","BAK1","HNF1B","TNFRSF1B"]} {"pathway":"GO_NATURAL_KILLER_CELL_PROLIFERATION","pval":0.36297,"padj":0.89036,"ES":0.92876,"NES":1.18631,"nMoreExtreme":20283,"size":9,"leadingEdge":["IL15","HLA-E","FLT3LG","ELF4"]} {"pathway":"GO_MITOTIC_CELL_CYCLE_ARREST","pval":0.24918,"padj":0.82387,"ES":0.92845,"NES":1.18622,"nMoreExtreme":14806,"size":15,"leadingEdge":["CDKN1A","NKX3-1","FAP"]} {"pathway":"GO_RESPONSE_TO_VITAMIN_D","pval":0.24669,"padj":0.82387,"ES":0.84458,"NES":1.18622,"nMoreExtreme":16081,"size":30,"leadingEdge":["IL15","CXCL10","PIM1","CYP27B1","TGFB1","PTGS2","TRIM25","PTN"]} {"pathway":"GO_REGULATION_OF_ION_TRANSMEMBRANE_TRANSPORT","pval":0.08189,"padj":0.64602,"ES":0.66475,"NES":1.1861,"nMoreExtreme":7591,"size":318,"leadingEdge":["ATP1B2","P2RX7","CXCL11","PDE4B","CXCL10","SLC31A2","CXCL9","KCNJ10","AGT","KCNJ2","CAMK2D","KCNJ15","SRI","RASGRF1","ABCB1","CTSS","TMEM109","ANK2","CLIC5","DYSF","LYN","KCNE5","ANXA3","RNF207","STAC3","JPH4","SLC8A1","SCN9A","GEM","PTAFR","KCNE1","PSEN2","CACNA1I","TGFB1","KCNMA1","HVCN1","ACTN2","CX3CL1","RGS9","MIR212","CLIC2","GLRX","KCNE1B","STOM","SHISA7","S100A1","ARC","MAPK8IP2","KCNMB1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SECRETION","pval":0.12543,"padj":0.71713,"ES":0.68894,"NES":1.18604,"nMoreExtreme":10694,"size":169,"leadingEdge":["GBP1","CD74","HLA-F","CEACAM1","BANK1","TLR8","PML","ZC3H12A","CARD17","CARD16","RSAD2","BTN2A2","EDN1","PTGER4","TIFAB","TNFAIP3","RSC1A1","TNF","NR1H3","LILRB1","P2RY12","TRIM9","UCP2","RHBDF2","GAS6","CX3CL1","SRCIN1","IL33","IL1R2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSPORT","pval":0.28747,"padj":0.84886,"ES":0.88006,"NES":1.18596,"nMoreExtreme":18086,"size":23,"leadingEdge":["KCNE5","KCNE1","ACTN2","MIR212","KCNE1B","NEDD4L"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_RECEPTOR_BINDING","pval":0.36499,"padj":0.89036,"ES":0.92847,"NES":1.18594,"nMoreExtreme":20396,"size":9,"leadingEdge":["B2M","NKX3-1","HFE"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION","pval":0.31072,"padj":0.86489,"ES":0.93401,"NES":1.18576,"nMoreExtreme":17538,"size":10,"leadingEdge":["NR1H3","NFKBIA","NR1H2"]} {"pathway":"GO_SPLICEOSOMAL_TRI_SNRNP_COMPLEX_ASSEMBLY","pval":0.25713,"padj":0.82758,"ES":0.93627,"NES":1.18562,"nMoreExtreme":14831,"size":12,"leadingEdge":["PRPF3","DDX20"]} {"pathway":"GO_REGULATION_OF_PROTEIN_DEUBIQUITINATION","pval":0.25713,"padj":0.82758,"ES":0.93627,"NES":1.18562,"nMoreExtreme":14831,"size":12,"leadingEdge":["ZC3H12A","TANK","TRIM21","OTUD4","SART3"]} {"pathway":"GO_RESPONSE_TO_DEFENSES_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION","pval":0.54204,"padj":0.9293,"ES":0.90631,"NES":1.18552,"nMoreExtreme":29462,"size":7,"leadingEdge":["TGFB1","GUCY1A1","SMAD3","EIF2AK2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_IMMUNOGLOBULIN_PRODUCTION","pval":0.36733,"padj":0.89036,"ES":0.92813,"NES":1.18551,"nMoreExtreme":20527,"size":9,"leadingEdge":["BCL6","PARP3","IL33","CD22"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_VIRAL_RELEASE_FROM_HOST_CELL","pval":0.2491,"padj":0.82387,"ES":0.93154,"NES":1.18548,"nMoreExtreme":14661,"size":14,"leadingEdge":["PML","TRIM21","TRIM25","MID2"]} {"pathway":"GO_PLASMA_MEMBRANE_PHOSPHOLIPID_SCRAMBLING","pval":0.25001,"padj":0.8245,"ES":0.93144,"NES":1.18535,"nMoreExtreme":14715,"size":14,"leadingEdge":["P2RX7","ANO4","XKR6","PLSCR4","PLSCR1","XKR8","XKR7","PLSCR2","ANO9"]} {"pathway":"GO_NAD_BIOSYNTHESIS_VIA_NICOTINAMIDE_RIBOSIDE_SALVAGE_PATHWAY","pval":0.24488,"padj":0.82387,"ES":0.93542,"NES":1.18535,"nMoreExtreme":14261,"size":13,"leadingEdge":["PARP10","PARP9","NAMPT","PTGS2"]} {"pathway":"GO_CITRULLINE_BIOSYNTHETIC_PROCESS","pval":0.53687,"padj":0.92816,"ES":0.83238,"NES":1.18534,"nMoreExtreme":27941,"size":4,"leadingEdge":["CPS1","ATP2B4","ALDH18A1","CAD"]} {"pathway":"GO_TYPE_I_INTERFERON_BIOSYNTHETIC_PROCESS","pval":0.31274,"padj":0.86489,"ES":0.93366,"NES":1.18531,"nMoreExtreme":17652,"size":10,"leadingEdge":["NMI","TLR8","IRF7","TLR7","TLR3","TLR4","TICAM1"]} {"pathway":"GO_ERK1_AND_ERK2_CASCADE","pval":0.1033,"padj":0.67471,"ES":0.67409,"NES":1.18531,"nMoreExtreme":9227,"size":238,"leadingEdge":["GBP1","CD74","NOD2","CEACAM1","CCL13","ATF3","AGT","RIPK2","CCL7","ICAM1","KLF4","CCL15","CCL8","SCIMP","RAPGEF2","BTN2A2","SLAMF1","MIR503","GLIPR2","PTGER4","CCL18","CCL5","LYN","GAREM1","FGF10","SEMA7A","NOTCH2","TNF","FLT1","DUSP10","RASGRP1","CCL1","PTPRC","CHI3L1","CCL4","FPR2","CCL2","PTPN2","SRC","TGFB1","CCL19","PDGFRA","PTPN1","PKHD1","GAS6","CCL3","CX3CL1","CFLAR"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NATURAL_KILLER_CELL_ACTIVATION","pval":0.31704,"padj":0.86626,"ES":0.89777,"NES":1.18525,"nMoreExtreme":19597,"size":20,"leadingEdge":["IL15","HLA-F","HLA-E","FLT3LG","IL12A","RASGRP1","GAS6","TICAM1"]} {"pathway":"GO_PRE_MIRNA_PROCESSING","pval":0.25445,"padj":0.82744,"ES":0.92766,"NES":1.18522,"nMoreExtreme":15119,"size":15,"leadingEdge":["ADAR","LIN28A","TUT7"]} {"pathway":"GO_PROTEIN_HOMOOLIGOMERIZATION","pval":0.09698,"padj":0.66591,"ES":0.67098,"NES":1.18513,"nMoreExtreme":8761,"size":259,"leadingEdge":["TIFA","GBP5","GBP1","GCH1","KCTD14","STEAP4","DPYS","KCNJ2","BCL2L11","TGM2","GSDMD","P2RX4","HLA-G","GLUL","NPM2","SOD2","DECR1","TRIM72","SMPD3","ANGPTL4","SRC","SLC22A1","IKBKE","ACTN2","IKZF4","ACPP","GLS","ILDR1","STOM","FCER1G","MARCKS","FLOT1","ARC","CPT1A"]} {"pathway":"GO_REGULATION_OF_INFLAMMATORY_RESPONSE","pval":0.09637,"padj":0.66591,"ES":0.67041,"NES":1.1851,"nMoreExtreme":8723,"size":263,"leadingEdge":["GBP5","IDO1","LRRK2","IL15","NOD2","HGF","HLA-E","ACOD1","JAK2","SUCNR1","AGT","KLF4","TGM2","C3","MEFV","TLR10","ZC3H12A","CYLD","STAP1","SBNO2","SLAMF8","PTGER4","BCL6","CCL18","CCL5","LYN","TNFAIP6","TLR7","LTA","TNFAIP3","BIRC3","MYD88","IL6","TLR3","SEMA7A","TNF","DUSP10","CD47","PIK3AP1","CCL1","PTPRC","NR1H3","SOCS3","PTPN2","IL2RA","SLC7A2","NFKBIA","PTGS2","CCL3","CX3CL1","USP18","GATA3","IL33","IL1R2","SMAD3"]} {"pathway":"GO_REGULATION_OF_NATURAL_KILLER_CELL_DIFFERENTIATION","pval":0.31395,"padj":0.86489,"ES":0.93347,"NES":1.18507,"nMoreExtreme":17720,"size":10,"leadingEdge":["IL15","FLT3LG","RASGRP1","GAS6"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE","pval":0.26041,"padj":0.82935,"ES":0.93582,"NES":1.18505,"nMoreExtreme":15020,"size":12,"leadingEdge":["ACTN2","GPM6B","GOPC"]} {"pathway":"GO_STRESS_GRANULE_ASSEMBLY","pval":0.28444,"padj":0.8471,"ES":0.91635,"NES":1.18505,"nMoreExtreme":17188,"size":17,"leadingEdge":["C9orf72","PUM2"]} {"pathway":"GO_REGULATION_OF_INTERLEUKIN_12_SECRETION","pval":0.54498,"padj":0.93088,"ES":0.90589,"NES":1.18498,"nMoreExtreme":29622,"size":7,"leadingEdge":["TLR8","LILRB1","LILRA5","MAPK11"]} {"pathway":"GO_MULTI_ORGANISM_MEMBRANE_ORGANIZATION","pval":0.31458,"padj":0.86509,"ES":0.93336,"NES":1.18493,"nMoreExtreme":17756,"size":10,"leadingEdge":["CCR5","GAS6","CD4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CYTOPLASMIC_TRANSLATION","pval":0.37113,"padj":0.89036,"ES":0.92763,"NES":1.18486,"nMoreExtreme":20739,"size":9,"leadingEdge":["LIN28A","YBX3"]} {"pathway":"GO_POLYAMINE_BIOSYNTHETIC_PROCESS","pval":0.2479,"padj":0.82387,"ES":0.93492,"NES":1.18471,"nMoreExtreme":14437,"size":13,"leadingEdge":["SAT1","AZIN2","SMS"]} {"pathway":"GO_POSITIVE_REGULATION_OF_T_HELPER_17_TYPE_IMMUNE_RESPONSE","pval":0.45166,"padj":0.90517,"ES":0.91785,"NES":1.18468,"nMoreExtreme":24886,"size":8,"leadingEdge":["IL12RB1","PRKCQ"]} {"pathway":"GO_RNA_DESTABILIZATION","pval":0.24457,"padj":0.82387,"ES":0.83909,"NES":1.18447,"nMoreExtreme":16010,"size":31,"leadingEdge":["ZC3H12A","MOV10","TRIM71","ZFP36","PLEKHN1","UPF1"]} {"pathway":"GO_REGULATION_OF_BROWN_FAT_CELL_DIFFERENTIATION","pval":0.28335,"padj":0.84565,"ES":0.93532,"NES":1.18441,"nMoreExtreme":16178,"size":11,"leadingEdge":["DUSP10","PTGS2","SIRT1"]} {"pathway":"GO_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT","pval":0.15756,"padj":0.76265,"ES":0.71203,"NES":1.18409,"nMoreExtreme":12583,"size":110,"leadingEdge":["CXCL11","PDE4B","CXCL10","CXCL9","CAMK2D","SRI","ANK2","DYSF","LYN","STAC3","JPH4","SLC8A1","GEM","PSEN2","TGFB1","CX3CL1","CLIC2"]} {"pathway":"GO_DETECTION_OF_OTHER_ORGANISM","pval":0.32054,"padj":0.86901,"ES":0.9325,"NES":1.18385,"nMoreExtreme":18092,"size":10,"leadingEdge":["NOD2","TLR4","TLR1"]} {"pathway":"GO_PEPTIDYL_TYROSINE_MODIFICATION","pval":0.08974,"padj":0.66008,"ES":0.66586,"NES":1.18383,"nMoreExtreme":8238,"size":296,"leadingEdge":["IL31RA","CD40","CD74","SOCS1","ITK","IL15","HGF","BANK1","LMTK2","JAK2","AGT","RIPK2","ICAM1","TNFSF18","CD80","JAK3","STAP1","IL12RB2","ENPP2","NCF1","MVP","STAP2","CCL5","LYN","IL12A","PARP14","TNFRSF14","PARP9","IL7","IL6","FGF10","TNF","FLT1","PTPRC","SOCS3","STAT3","PTPN2","SRC","TGFB1","PDGFRA","PTPN1","GAS6","EPHA10","SRCIN1","SEMA4D","SPINK1","PDGFB"]} {"pathway":"GO_PROTEIN_CATABOLIC_PROCESS","pval":0.02043,"padj":0.36159,"ES":0.64814,"NES":1.18368,"nMoreExtreme":2023,"size":813,"leadingEdge":["UBD","PSME2","P2RX7","LRRK2","PSMB9","FBXO6","LAMP3","TBX21","CEACAM1","ATP13A2","PSME1","PSMB10","NUB1","IFI27","UBE2L6","PSMB8","PML","RNF19B","CTSS","CYLD","CTSO","DTX3L","PMAIP1","DYSF","CHMP4C","PYHIN1","CTRL","CTSL","AMER1","TNFAIP3","EDEM1","RNF144B","CTSZ","TNF","PSMA4","PSMA2","SPOPL","RBCK1","CUL1","TRIM72","AZIN2","UBE2A","TRIM71","TRIM9","GCLC","PSMA5","CTSC","UBE2Z","ADGRB1","ISG15","USP18","TRIM25","ERLIN1","NFE2L2","IL33","HERPUD1","SMAD3"]} {"pathway":"GO_ACTIN_MEDIATED_CELL_CONTRACTION","pval":0.17189,"padj":0.77295,"ES":0.72881,"NES":1.18361,"nMoreExtreme":13208,"size":87,"leadingEdge":["PDE4B","KCNJ2","CAMK2D","SRI","ANK2","KCNE5","MYH7","RNF207","DES","KCNE1","ACTN2","KCNE1B"]} {"pathway":"GO_NEUROTRANSMITTER_TRANSPORT","pval":0.11839,"padj":0.70259,"ES":0.68045,"NES":1.18358,"nMoreExtreme":10305,"size":197,"leadingEdge":["SLC6A12","P2RX7","LRRK2","STX11","GRIN3A","KCNJ10","ERC2","PRRT2","MCTP2","EDN1","SLC18A1","NAAA","LYN","DTNBP1","GLUL","CADPS2","SLC25A22","LILRB1","KMO","TRIM9","SYT5","SLC22A1","GPM6B","SLC44A2","NAPA","STX3","SYT17","FCER1G"]} {"pathway":"GO_NEURON_REMODELING","pval":0.32162,"padj":0.86901,"ES":0.93229,"NES":1.18357,"nMoreExtreme":18153,"size":10,"leadingEdge":["SCARF1","C3","RND1","FARP2","CX3CL1"]} {"pathway":"GO_COPII_COATED_VESICLE_BUDDING","pval":0.18653,"padj":0.78157,"ES":0.74899,"NES":1.18339,"nMoreExtreme":13782,"size":68,"leadingEdge":["CTSZ","CTSC","NAPA","TRAPPC6A"]} {"pathway":"GO_PRONEPHROS_DEVELOPMENT","pval":0.55372,"padj":0.93396,"ES":0.9046,"NES":1.18329,"nMoreExtreme":30097,"size":7,"leadingEdge":["HNF1B","SEC61A1"]} {"pathway":"GO_DEDIFFERENTIATION","pval":0.46006,"padj":0.90517,"ES":0.91668,"NES":1.18317,"nMoreExtreme":25349,"size":8,"leadingEdge":["PDGFB","ESRRB","OLFM2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_DEGRANULATION","pval":0.29088,"padj":0.85125,"ES":0.93427,"NES":1.18307,"nMoreExtreme":16608,"size":11,"leadingEdge":["HLA-F","CEACAM1","CD84"]} {"pathway":"GO_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_CLEARANCE","pval":0.29128,"padj":0.85125,"ES":0.93419,"NES":1.18298,"nMoreExtreme":16631,"size":11,"leadingEdge":["LIPG","AMN","SCARB1"]} {"pathway":"GO_EMBRYONIC_CAMERA_TYPE_EYE_MORPHOGENESIS","pval":0.31219,"padj":0.86489,"ES":0.90825,"NES":1.18287,"nMoreExtreme":18993,"size":18,"leadingEdge":["PROX1","HIPK2"]} {"pathway":"GO_REGULATION_OF_ER_ASSOCIATED_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS","pval":0.38181,"padj":0.89036,"ES":0.92605,"NES":1.18285,"nMoreExtreme":21336,"size":9,"leadingEdge":["NFE2L2","HERPUD1","USP14"]} {"pathway":"GO_REGULATION_OF_TRANSLATIONAL_INITIATION","pval":0.18414,"padj":0.77988,"ES":0.74336,"NES":1.18285,"nMoreExtreme":13741,"size":72,"leadingEdge":["BANK1","CCL5","TNF","EIF2AK2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION","pval":0.27226,"padj":0.83739,"ES":0.93407,"NES":1.18284,"nMoreExtreme":15704,"size":12,"leadingEdge":["PLEK","ACTN2","WDR1"]} {"pathway":"GO_TRANS_SYNAPTIC_SIGNALING_MODULATING_SYNAPTIC_TRANSMISSION","pval":0.32621,"padj":0.87041,"ES":0.93167,"NES":1.18279,"nMoreExtreme":18412,"size":10,"leadingEdge":["GUCY1A1","GUCY1B1","PLAT"]} {"pathway":"GO_RRNA_3_END_PROCESSING","pval":0.3826,"padj":0.89036,"ES":0.92594,"NES":1.18271,"nMoreExtreme":21380,"size":9,"leadingEdge":["ERI1","EXOSC7"]} {"pathway":"GO_INTERFERON_GAMMA_BIOSYNTHETIC_PROCESS","pval":0.25812,"padj":0.82758,"ES":0.93334,"NES":1.1827,"nMoreExtreme":15032,"size":13,"leadingEdge":["TLR8","IL27","TLR7","TLR3","EBI3","LILRB1"]} {"pathway":"GO_GOLGI_RIBBON_FORMATION","pval":0.2733,"padj":0.83739,"ES":0.93386,"NES":1.18257,"nMoreExtreme":15764,"size":12,"leadingEdge":["OPTN","GCC2"]} {"pathway":"GO_AROMATIC_AMINO_ACID_FAMILY_METABOLIC_PROCESS","pval":0.32996,"padj":0.87332,"ES":0.93119,"NES":1.18218,"nMoreExtreme":18624,"size":10,"leadingEdge":["IDO1","IDO2","KYNU","KMO"]} {"pathway":"GO_NEUROMUSCULAR_SYNAPTIC_TRANSMISSION","pval":0.29884,"padj":0.85717,"ES":0.9141,"NES":1.18214,"nMoreExtreme":18058,"size":17,"leadingEdge":["STAC3","EGR3","RAPSN","KIF1B"]} {"pathway":"GO_REGULATION_OF_HEART_MORPHOGENESIS","pval":0.24391,"padj":0.82387,"ES":0.83293,"NES":1.18212,"nMoreExtreme":16039,"size":32,"leadingEdge":["PIM1","RNF207","ROBO1","FOXC1","SIX1"]} {"pathway":"GO_REGULATION_OF_TUBE_SIZE","pval":0.17103,"padj":0.77295,"ES":0.72468,"NES":1.18206,"nMoreExtreme":13222,"size":91,"leadingEdge":["GCH1","CD38","AGT","ICAM1","NPR1","EDN1","COMP","SOD2","SLC8A1","PTAFR","GCLC","KCNMA1","GUCY1A1","P2RY2","PTGS2","FOXC1","SCPEP1","EDNRA","KCNMB1","ADORA2A","KCNMB4"]} {"pathway":"GO_ENDOTHELIAL_CELL_ACTIVATION","pval":0.33102,"padj":0.87332,"ES":0.931,"NES":1.18193,"nMoreExtreme":18684,"size":10,"leadingEdge":["CXCL10","P2RX4","TCIM"]} {"pathway":"GO_DICARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS","pval":0.38711,"padj":0.89277,"ES":0.92532,"NES":1.18192,"nMoreExtreme":21632,"size":9,"leadingEdge":["KYNU","KMO","GLS","SLC1A3"]} {"pathway":"GO_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY","pval":0.2614,"padj":0.83152,"ES":0.85042,"NES":1.18182,"nMoreExtreme":16885,"size":28,"leadingEdge":["MYOF","VEGFC","FGF10","FLT1","PTPN1"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_THYROID_HORMONE_STIMULUS","pval":0.27753,"padj":0.84047,"ES":0.93323,"NES":1.18177,"nMoreExtreme":16008,"size":12,"leadingEdge":["CTSS","CTSL","GCLC","SIX1"]} {"pathway":"GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY","pval":0.12077,"padj":0.7062,"ES":0.67874,"NES":1.18165,"nMoreExtreme":10532,"size":199,"leadingEdge":["P2RX7","HGF","TNFSF10","ATF3","JAK2","AGT","BCL2A1","IFI27","FAS","ICAM1","BCL2L11","PML","CYLD","PMAIP1","IL12A","IL7","TNFAIP3","CD70","TLR3","FGF10","TNF","RBCK1","PTPRC","GCLC","SRC","TGFB1","SORT1","IFI6","MCL1","SH3RF1","CX3CL1","CFLAR","IL33","SMAD3","TRAF1","BAK1","IL1A","NGF"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELL_POPULATION_PROLIFERATION","pval":0.04646,"padj":0.53858,"ES":0.65108,"NES":1.18127,"nMoreExtreme":4509,"size":545,"leadingEdge":["IRF1","PLAAT4","IDO1","ASCL2","CD274","PDCD1LG2","IL15","CEACAM1","SSTR2","STAT1","CTLA4","JAK2","OVOL1","KLF4","IFITM1","CD80","TSPAN32","PML","CCL8","IFIT3","PARP10","RAPGEF2","SCIN","ATF5","NPR1","BTN2A2","NRK","MIR503","HLA-G","BCL6","LYN","IL12A","LTA","TNFRSF14","SOD2","PTPRU","TNFAIP3","IL6","FGF10","TNF","FLT1","HPN","CUL1","DUSP10","CD86","CYP27B1","LILRB1","CCL2","STAT3","PTPN2","PAK1","MNDA","TGFB1","ROBO1","IL2RA","CXCL8","CDKN1A","CDKN1C","ADGRB1","PTGS2","PLPP1","RARRES1","GATA3","NKX3-1","ADAMTS8","SMAD3","GAS8","BAK1","IL1A","NUPR1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING","pval":0.30351,"padj":0.86058,"ES":0.91337,"NES":1.1812,"nMoreExtreme":18340,"size":17,"leadingEdge":["KLF4","TGFB1","FOXC1","GATA3","GTF2B","IGF1"]} {"pathway":"GO_RESPONSE_TO_BACTERIAL_LIPOPROTEIN","pval":0.56432,"padj":0.93517,"ES":0.90297,"NES":1.18116,"nMoreExtreme":30673,"size":7,"leadingEdge":["TLR1","CD36"]} {"pathway":"GO_PROTEIN_O_LINKED_GLYCOSYLATION_VIA_THREONINE","pval":0.56564,"padj":0.93517,"ES":0.90269,"NES":1.18079,"nMoreExtreme":30745,"size":7,"leadingEdge":["GALNT3","GALNT16"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELL_CELL_ADHESION_MEDIATED_BY_CADHERIN","pval":0.47304,"padj":0.90882,"ES":0.91477,"NES":1.1807,"nMoreExtreme":26064,"size":8,"leadingEdge":["PTPRU","FLOT1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MACROPHAGE_ACTIVATION","pval":0.28331,"padj":0.84565,"ES":0.93228,"NES":1.18057,"nMoreExtreme":16341,"size":12,"leadingEdge":["IL31RA","ZC3H12A","PTPRC","NR1H3","CX3CL1"]} {"pathway":"GO_CARDIAC_MUSCLE_CONTRACTION","pval":0.16669,"padj":0.77278,"ES":0.71501,"NES":1.1805,"nMoreExtreme":13156,"size":102,"leadingEdge":["PDE4B","KCNJ2","CAMK2D","SRI","ZC3H12A","P2RX4","ANK2","KCNE5","MYH7","RNF207","SLC8A1","KCNE1","CLIC2","KCNE1B"]} {"pathway":"GO_REGULATION_OF_ALKALINE_PHOSPHATASE_ACTIVITY","pval":0.39584,"padj":0.89503,"ES":0.9242,"NES":1.18049,"nMoreExtreme":22120,"size":9,"leadingEdge":["TNF","PPARGC1B","SEMA4D","SMAD3","MEF2C"]} {"pathway":"GO_MEMBRANE_RAFT_ORGANIZATION","pval":0.30692,"padj":0.86308,"ES":0.91281,"NES":1.18047,"nMoreExtreme":18546,"size":17,"leadingEdge":["S100A10","PTPRC","FLOT1","NPC1","ABCA7"]} {"pathway":"GO_GERMINAL_CENTER_FORMATION","pval":0.2702,"padj":0.83739,"ES":0.93154,"NES":1.18042,"nMoreExtreme":15736,"size":13,"leadingEdge":["TNFSF13B","BCL6","TNFAIP3","NFKB2","KLHL6"]} {"pathway":"GO_RESPONSE_TO_ZINC_ION","pval":0.23019,"padj":0.81508,"ES":0.80539,"NES":1.1803,"nMoreExtreme":15634,"size":39,"leadingEdge":["P2RX7","ATP13A2","VCAM1","P2RX4","MT2A","MT1M","MT1E","MT1H","HVCN1","MT1G","ASS1","SLC30A4"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_NITRIC_OXIDE_BIOSYNTHETIC_PROCESS","pval":0.27478,"padj":0.83769,"ES":0.92738,"NES":1.18019,"nMoreExtreme":16173,"size":14,"leadingEdge":["ZC3H12A","MIR212","ATP2B4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_KERATINOCYTE_DIFFERENTIATION","pval":0.30599,"padj":0.86262,"ES":0.93189,"NES":1.18007,"nMoreExtreme":17471,"size":11,"leadingEdge":["CYP27B1","FOXC1","PRKCH"]} {"pathway":"GO_AUTOPHAGY_OF_MITOCHONDRION","pval":0.18995,"padj":0.78784,"ES":0.74421,"NES":1.18003,"nMoreExtreme":14105,"size":70,"leadingEdge":["ATP13A2","OPTN","ATG3","RB1CC1"]} {"pathway":"GO_CD4_POSITIVE_ALPHA_BETA_T_CELL_LINEAGE_COMMITMENT","pval":0.28077,"padj":0.84299,"ES":0.92352,"NES":1.17993,"nMoreExtreme":16683,"size":15,"leadingEdge":["IL12RB1","TBX21","SLAMF6","IRF4","IL6","STAT3"]} {"pathway":"GO_PLASMA_MEMBRANE_ORGANIZATION","pval":0.17945,"padj":0.77529,"ES":0.73196,"NES":1.17984,"nMoreExtreme":13633,"size":81,"leadingEdge":["P2RX7","MYOF","ANO4","ANK2","DYSF","XKR6","PLSCR4","PLSCR1","FCHO1","TRIM72","XKR8","PTPRC","XKR7","SPTA1","FLOT1"]} {"pathway":"GO_CHLORIDE_ION_HOMEOSTASIS","pval":0.34277,"padj":0.87929,"ES":0.92925,"NES":1.17972,"nMoreExtreme":19347,"size":10,"leadingEdge":["SLC12A3","SLC12A7","CKB","SLC12A2"]} {"pathway":"GO_PROTEIN_O_LINKED_FUCOSYLATION","pval":0.4795,"padj":0.91524,"ES":0.91392,"NES":1.17961,"nMoreExtreme":26420,"size":8,"leadingEdge":["SLC35C2","MFNG"]} {"pathway":"GO_INTRACELLULAR_RECEPTOR_SIGNALING_PATHWAY","pval":0.11271,"padj":0.69864,"ES":0.67198,"NES":1.17952,"nMoreExtreme":10026,"size":230,"leadingEdge":["TIFA","NOD2","PADI2","JAK2","PIM1","RIPK2","PML","CYLD","IRF7","IFIH1","DDX60","NR4A3","TNFAIP3","BIRC3","NCOA1","CYP27B1","DDX58","NR1H3","NR4A2","STAT3","DHX58","PAK1","RUNX1","SRC","NFKBIA","PLPP1","NKX3-1","PPARGC1B","RORB","NCOA4","ESRRB","TLR4","ALDH1A2","ALPK1","TBX1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS","pval":0.07519,"padj":0.63068,"ES":0.65635,"NES":1.17948,"nMoreExtreme":7102,"size":381,"leadingEdge":["P2RX7","CALCOCO2","LRRK2","OPTN","NUB1","RIPK2","BCL2L11","TRIM22","RNF19B","MEFV","ZC3H12A","RALB","GTPBP1","DTX3L","PYHIN1","RUFY4","AMER1","TNFAIP3","EDEM1","RNF144B","TNF","MOV10","TRIM71","GCLC","UVRAG","TRIM21","CTSC","PTPN1","PLEKHF1","NFE2L2","IL33","HERPUD1","ZFP36","PRR5L","NUPR1","RNF19A","ESRRB","C9orf72"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY","pval":0.18774,"padj":0.78227,"ES":0.73995,"NES":1.17946,"nMoreExtreme":14041,"size":73,"leadingEdge":["LAMP3","HGF","KLF4","CARD16","BIRC3","SERPINB9","SRC","IFI6","SH3RF1","PTGS2","GAS6","CFLAR","BIRC7","HERPUD1","NGF","TNFAIP8","ADORA2A"]} {"pathway":"GO_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY","pval":0.20011,"padj":0.79183,"ES":0.75957,"NES":1.17941,"nMoreExtreme":14454,"size":59,"leadingEdge":["IRF1","ACOD1","CD300LF","IRF7","RSAD2","LILRA2","LYN","TICAM2","IRF4","TNFAIP3","LILRA4","BIRC3","TLR3","NR1H3","WDFY1","TREML4","OTUD4"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_DRUG","pval":0.29579,"padj":0.85691,"ES":0.91806,"NES":1.1794,"nMoreExtreme":17718,"size":16,"leadingEdge":["LRRK2","HGF","NR4A3","TXN","NFE2L2","MET"]} {"pathway":"GO_RESPONSE_TO_INTERLEUKIN_15","pval":0.27906,"padj":0.84181,"ES":0.92673,"NES":1.17936,"nMoreExtreme":16425,"size":14,"leadingEdge":["IL15RA","IL15","JAK3","IL2RG","STAT5A","STAT3","PLCB1"]} {"pathway":"GO_TONGUE_MORPHOGENESIS","pval":0.57293,"padj":0.94049,"ES":0.90151,"NES":1.17925,"nMoreExtreme":31141,"size":7,"leadingEdge":["TBX1","SIX1","CYP26B1"]} {"pathway":"GO_INTERLEUKIN_23_PRODUCTION","pval":0.59355,"padj":0.94378,"ES":0.88184,"NES":1.17917,"nMoreExtreme":31855,"size":6,"leadingEdge":["MYD88","TGFB1","TLR4"]} {"pathway":"GO_MITOCHONDRIAL_TRANSMEMBRANE_TRANSPORT","pval":0.17897,"padj":0.77529,"ES":0.72781,"NES":1.17917,"nMoreExtreme":13703,"size":85,"leadingEdge":["SLC25A28","SLC25A22","PSEN2","UCP2","CPT1A","SLC25A13"]} {"pathway":"GO_HEPATOCYTE_APOPTOTIC_PROCESS","pval":0.2914,"padj":0.85125,"ES":0.93116,"NES":1.17914,"nMoreExtreme":16808,"size":12,"leadingEdge":["CFLAR","BID"]} {"pathway":"GO_INCLUSION_BODY_ASSEMBLY","pval":0.30463,"padj":0.86182,"ES":0.88073,"NES":1.17913,"nMoreExtreme":19060,"size":22,"leadingEdge":["UBD","SNCAIP"]} {"pathway":"GO_BETA_CATENIN_DESTRUCTION_COMPLEX_DISASSEMBLY","pval":0.32865,"padj":0.87192,"ES":0.90533,"NES":1.17906,"nMoreExtreme":19995,"size":18,"leadingEdge":["AMER1","WNT1","DVL2"]} {"pathway":"GO_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS","pval":0.27036,"padj":0.83739,"ES":0.85336,"NES":1.17875,"nMoreExtreme":17383,"size":27,"leadingEdge":["GSAP","LYN","HAP1"]} {"pathway":"GO_EPITHELIAL_CELL_PROLIFERATION_INVOLVED_IN_PROSTATE_GLAND_DEVELOPMENT","pval":0.3487,"padj":0.88316,"ES":0.92841,"NES":1.17865,"nMoreExtreme":19682,"size":10,"leadingEdge":["NKX3-1","CDKN1B"]} {"pathway":"GO_EXOCYTIC_PROCESS","pval":0.19199,"padj":0.79001,"ES":0.74327,"NES":1.17854,"nMoreExtreme":14256,"size":70,"leadingEdge":["PLEK","STX11","ERC2","PRRT2","RALB","LYN","CADPS2","NAPA","STX3","FCER1G"]} {"pathway":"GO_METAL_ION_HOMEOSTASIS","pval":0.05987,"padj":0.58367,"ES":0.65149,"NES":1.1784,"nMoreExtreme":5757,"size":474,"leadingEdge":["ATP1B2","CD40","P2RX7","SNX10","CXCL11","CD38","CXCL10","CCL13","ATP13A2","SLC31A2","CXCL9","KCNJ10","JAK2","AGT","STEAP4","SLC12A3","CCL7","KCNJ2","MCOLN2","CAMK2D","CCL15","TGM2","PML","FAM20A","SRI","B2M","CCL8","CCRL2","P2RX4","NPR1","EDN1","SCO2","SLC25A28","ANK2","MT2A","PTGER4","CCL5","LYN","MT1M","JPH4","PTGER2","SLC8A1","CUL1","GPR18","F2RL2","MT1E","CCR5","CCL1","SLC12A7","CXCL12","CYP27B1","PTPRC","FPR2","ACKR4","TMTC2","TGFB1","KCNMA1","CCL19","CCR6","MT1H","ATP6V1A","PDGFRA","C19orf12","GRINA","PKHD1","LPAR1","CCL3","CX3CL1","MT1G","HERPUD1","PLCB1","CLIC2","SLC8A2","SMAD3"]} {"pathway":"GO_GTP_METABOLIC_PROCESS","pval":0.28467,"padj":0.84743,"ES":0.92581,"NES":1.17818,"nMoreExtreme":16755,"size":14,"leadingEdge":["LRRK2","GIMAP7","GTPBP1","RHOQ","AK4"]} {"pathway":"GO_AMINO_ACID_BETAINE_METABOLIC_PROCESS","pval":0.48756,"padj":0.91689,"ES":0.9128,"NES":1.17816,"nMoreExtreme":26864,"size":8,"leadingEdge":["CPT1A","CROT"]} {"pathway":"GO_HISTONE_H3_K27_METHYLATION","pval":0.28245,"padj":0.84533,"ES":0.92964,"NES":1.17801,"nMoreExtreme":16449,"size":13,"leadingEdge":["GATA3","EED"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MONONUCLEAR_CELL_MIGRATION","pval":0.32567,"padj":0.87041,"ES":0.89223,"NES":1.17792,"nMoreExtreme":20130,"size":20,"leadingEdge":["CXCL10","CCL5","TNF","CCL1","CXCL12","FPR2","TGFB1","CCR1"]} {"pathway":"GO_MIRNA_CATABOLIC_PROCESS","pval":0.35439,"padj":0.88844,"ES":0.92768,"NES":1.17772,"nMoreExtreme":20003,"size":10,"leadingEdge":["ZC3H12A","LIN28A"]} {"pathway":"GO_AMMONIUM_ION_METABOLIC_PROCESS","pval":0.23318,"padj":0.81557,"ES":0.80362,"NES":1.17771,"nMoreExtreme":15837,"size":39,"leadingEdge":["PLAAT4","PLAAT3","PLA2G4C","LPCAT2","PLA2G4A","SMPD3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MONOOXYGENASE_ACTIVITY","pval":0.35643,"padj":0.88877,"ES":0.9274,"NES":1.17737,"nMoreExtreme":20118,"size":10,"leadingEdge":["CYP27B1","MIR212","ATP2B4"]} {"pathway":"GO_LEUKOCYTE_AGGREGATION","pval":0.35643,"padj":0.88877,"ES":0.9274,"NES":1.17737,"nMoreExtreme":20118,"size":10,"leadingEdge":["NR4A3","HAS2","SEMA4D","CD44"]} {"pathway":"GO_CATECHOLAMINE_BIOSYNTHETIC_PROCESS","pval":0.32088,"padj":0.86901,"ES":0.92976,"NES":1.17736,"nMoreExtreme":18321,"size":11,"leadingEdge":["GCH1","NR4A2","GATA3"]} {"pathway":"GO_GLUCOCORTICOID_METABOLIC_PROCESS","pval":0.30125,"padj":0.85813,"ES":0.9297,"NES":1.1773,"nMoreExtreme":17376,"size":12,"leadingEdge":["HSD11B1","DKK3"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_X_RAY","pval":0.30153,"padj":0.85813,"ES":0.92964,"NES":1.17722,"nMoreExtreme":17392,"size":12,"leadingEdge":["GATA3","TP53BP1"]} {"pathway":"GO_CILIUM_MOVEMENT_INVOLVED_IN_CELL_MOTILITY","pval":0.295,"padj":0.85578,"ES":0.92131,"NES":1.1771,"nMoreExtreme":17529,"size":15,"leadingEdge":["GAS8","CFAP20"]} {"pathway":"GO_UREA_CYCLE","pval":0.49493,"padj":0.91907,"ES":0.91184,"NES":1.17693,"nMoreExtreme":27270,"size":8,"leadingEdge":["ASS1","CPS1"]} {"pathway":"GO_ANGIOTENSIN_ACTIVATED_SIGNALING_PATHWAY","pval":0.32333,"padj":0.86974,"ES":0.92936,"NES":1.17686,"nMoreExtreme":18461,"size":11,"leadingEdge":["SRC","ACTN2","AGTRAP","ROCK1"]} {"pathway":"GO_TOLL_LIKE_RECEPTOR_4_SIGNALING_PATHWAY","pval":0.2628,"padj":0.83229,"ES":0.84235,"NES":1.17686,"nMoreExtreme":17053,"size":29,"leadingEdge":["ACOD1","RIPK2","LILRA2","LYN","TICAM2","TNFAIP3","PIK3AP1","NR1H3","WDFY1","NFKBIA","TLR4"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS","pval":0.15302,"padj":0.75292,"ES":0.69464,"NES":1.17665,"nMoreExtreme":12628,"size":136,"leadingEdge":["XRN1","RMI2","ZC3H12A","BCL6","PARP3","NBN","SRC","TGFB1","CGAS","HELB","STN1","GATA3"]} {"pathway":"GO_DETECTION_OF_MECHANICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_SOUND","pval":0.41831,"padj":0.89503,"ES":0.921,"NES":1.17639,"nMoreExtreme":23376,"size":9,"leadingEdge":["HPN","PDZD7","COL11A1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PINOCYTOSIS","pval":0.57888,"padj":0.94163,"ES":0.85518,"NES":1.17637,"nMoreExtreme":30630,"size":5,"leadingEdge":["NR1H3","STX1B"]} {"pathway":"GO_REGULATION_OF_CHRONIC_INFLAMMATORY_RESPONSE","pval":0.49838,"padj":0.91907,"ES":0.9114,"NES":1.17636,"nMoreExtreme":27460,"size":8,"leadingEdge":["IDO1","CCL5","LTA","TNFAIP3","TNF"]} {"pathway":"GO_PROTEIN_ADP_RIBOSYLATION","pval":0.27856,"padj":0.84118,"ES":0.85681,"NES":1.17634,"nMoreExtreme":17822,"size":26,"leadingEdge":["ART3","PARP10","PARP12","PARP14","PARP3","PARP9","PARP11","PARP15"]} {"pathway":"GO_PEPTIDYL_SERINE_DEPHOSPHORYLATION","pval":0.31192,"padj":0.86489,"ES":0.91551,"NES":1.17613,"nMoreExtreme":18684,"size":16,"leadingEdge":["PPP1R16B","PPP5C"]} {"pathway":"GO_MULTI_MULTICELLULAR_ORGANISM_PROCESS","pval":0.14087,"padj":0.73814,"ES":0.68549,"NES":1.17611,"nMoreExtreme":11920,"size":161,"leadingEdge":["IDO1","CD38","APOL2","ACOD1","AGT","PZP","CYP1A1","EDN1","NRK","MAFF","CLIC5","PLA2G4C","UBE2A","CYP27B1","PTAFR","INSL4","TGFB1","UCP2","NAMPT","PTGS2"]} {"pathway":"GO_STRESS_RESPONSE_TO_METAL_ION","pval":0.30723,"padj":0.86308,"ES":0.92874,"NES":1.17608,"nMoreExtreme":17721,"size":12,"leadingEdge":["MT2A","MT1M","MT1E","MT1H","MT1G","HSPA5"]} {"pathway":"GO_REGULATION_OF_APOPTOTIC_CELL_CLEARANCE","pval":0.42196,"padj":0.89612,"ES":0.92055,"NES":1.17582,"nMoreExtreme":23580,"size":9,"leadingEdge":["C4A","C4B","C2","C3","CD300LF","CCL2"]} {"pathway":"GO_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES","pval":0.13345,"padj":0.72971,"ES":0.67911,"NES":1.1758,"nMoreExtreme":11502,"size":184,"leadingEdge":["IL18BP","LRRK2","GCH1","HGF","STAT1","KLF4","EDN1","NCF1","NR4A3","SOD2","TNFAIP3","IL6","TXN","TNF","SLC8A1","SMPD3","SRC","CCL19","UCP2","TXNIP","PRDX1","PDGFRA","NME8","GUCY1B1","CFLAR","NFE2L2","PPARGC1B"]} {"pathway":"GO_RESPONSE_TO_UV_C","pval":0.30221,"padj":0.85863,"ES":0.92024,"NES":1.17574,"nMoreExtreme":17957,"size":15,"leadingEdge":["CARD16","BAK1","BCL3"]} {"pathway":"GO_MACROPHAGE_CYTOKINE_PRODUCTION","pval":0.31476,"padj":0.86509,"ES":0.9151,"NES":1.17559,"nMoreExtreme":18854,"size":16,"leadingEdge":["CD74","HLA-G","SEMA7A","LILRB1","TGFB1","GAS6","TLR4"]} {"pathway":"GO_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS","pval":0.21874,"padj":0.80167,"ES":0.77568,"NES":1.17529,"nMoreExtreme":15348,"size":49,"leadingEdge":["IDO1","CD74","P2RX7","CD274","PDCD1","JAK3","GIMAP8","BCL6","CCL5","LYN","PRELID1","BIRC7"]} {"pathway":"GO_CONNECTIVE_TISSUE_REPLACEMENT","pval":0.42452,"padj":0.89678,"ES":0.9201,"NES":1.17525,"nMoreExtreme":23723,"size":9,"leadingEdge":["TGFB1","IL1A","ROCK1"]} {"pathway":"GO_HOMEOSTASIS_OF_NUMBER_OF_CELLS_WITHIN_A_TISSUE","pval":0.28012,"padj":0.84243,"ES":0.85589,"NES":1.17508,"nMoreExtreme":17922,"size":26,"leadingEdge":["P2RX7","FLT3LG","CSF1","IL7","EXOC5"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_VASCULAR_SMOOTH_MUSCLE_CELL_DIFFERENTIATION","pval":0.50524,"padj":0.91988,"ES":0.91033,"NES":1.17497,"nMoreExtreme":27838,"size":8,"leadingEdge":["PDGFB","NFATC1","NFATC3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CHEMOTAXIS","pval":0.16808,"padj":0.77295,"ES":0.70538,"NES":1.17488,"nMoreExtreme":13459,"size":112,"leadingEdge":["CD74","CXCL10","SUCNR1","CCL7","P2RX4","EDN1","VEGFC","DYSF","CCL5","IL12A","CSF1","IL6","FGF10","CAMK1D","CCL1","CXCL12","CCL4","FPR2","F3","P2RY12","TGFB1","CCL19","CCR6","CXCL8","LPAR1","RIPOR2","GAS6","CCL3","DAPK2","PDGFB","SMAD3","STX3","SLIT2"]} {"pathway":"GO_ESTABLISHMENT_OF_RNA_LOCALIZATION","pval":0.1341,"padj":0.72971,"ES":0.67833,"NES":1.17487,"nMoreExtreme":11567,"size":185,"leadingEdge":["SIDT2","MVP","PARP11","ZFP36","FLOT1","ARC","UPF1"]} {"pathway":"GO_TRAIL_ACTIVATED_APOPTOTIC_SIGNALING_PATHWAY","pval":0.37055,"padj":0.89036,"ES":0.92542,"NES":1.17485,"nMoreExtreme":20915,"size":10,"leadingEdge":["ATF3","CASP8"]} {"pathway":"GO_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM","pval":0.16697,"padj":0.77278,"ES":0.70425,"NES":1.1748,"nMoreExtreme":13408,"size":114,"leadingEdge":["GCH1","CD38","CEACAM1","AGT","ICAM1","NPR1","EDN1","COMP","SOD2","SLC8A1","PTAFR","GCLC","SRC","TGFB1","KCNMA1","GUCY1A1","P2RY2","PTGS2","FOXC1","SLIT2","SCPEP1","EDNRA","KCNMB1"]} {"pathway":"GO_REGULATION_OF_TRIGLYCERIDE_BIOSYNTHETIC_PROCESS","pval":0.30732,"padj":0.86308,"ES":0.91945,"NES":1.17473,"nMoreExtreme":18261,"size":15,"leadingEdge":["C3","DGAT2","NR1H3","SIK1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_RNA_METABOLIC_PROCESS","pval":0.20222,"padj":0.79569,"ES":0.75049,"NES":1.17468,"nMoreExtreme":14769,"size":63,"leadingEdge":["TGFB1","LIN28A","PAF1"]} {"pathway":"GO_CELLULAR_HYPEROSMOTIC_RESPONSE","pval":0.37133,"padj":0.89036,"ES":0.92526,"NES":1.17465,"nMoreExtreme":20959,"size":10,"leadingEdge":["RCSD1","YBX3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_GLIAL_CELL_PROLIFERATION","pval":0.33674,"padj":0.87637,"ES":0.92749,"NES":1.17449,"nMoreExtreme":19227,"size":11,"leadingEdge":["ASCL2","PTN"]} {"pathway":"GO_T_CELL_LINEAGE_COMMITMENT","pval":0.32026,"padj":0.86901,"ES":0.88346,"NES":1.17446,"nMoreExtreme":19931,"size":21,"leadingEdge":["IL12RB1","TBX21","SLAMF6","CYLD","IL7","IRF4","IL6","STAT3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT","pval":0.21296,"padj":0.7999,"ES":0.76504,"NES":1.17442,"nMoreExtreme":15158,"size":54,"leadingEdge":["LRRK2","TXN","KCNE1","CD84"]} {"pathway":"GO_MODULATION_BY_HOST_OF_VIRAL_GENOME_REPLICATION","pval":0.30922,"padj":0.86471,"ES":0.91917,"NES":1.17437,"nMoreExtreme":18374,"size":15,"leadingEdge":["IFI27","CCL8","ZC3H12A","STOM"]} {"pathway":"GO_COCHLEA_MORPHOGENESIS","pval":0.34761,"padj":0.88271,"ES":0.90162,"NES":1.17423,"nMoreExtreme":21148,"size":18,"leadingEdge":["TIFAB","HPN","TBX1","NEUROG1","SIX1","DVL2"]} {"pathway":"GO_LUNG_GROWTH","pval":0.59383,"padj":0.94378,"ES":0.89757,"NES":1.17409,"nMoreExtreme":32277,"size":7,"leadingEdge":["FGF10","TMEM38B"]} {"pathway":"GO_RELAXATION_OF_CARDIAC_MUSCLE","pval":0.30278,"padj":0.85939,"ES":0.92651,"NES":1.17405,"nMoreExtreme":17633,"size":13,"leadingEdge":["PDE4B","KCNJ2","CAMK2D","P2RX4","SLC8A1"]} {"pathway":"GO_REGULATION_OF_NAD_P_H_OXIDASE_ACTIVITY","pval":0.43191,"padj":0.90025,"ES":0.91909,"NES":1.17395,"nMoreExtreme":24136,"size":9,"leadingEdge":["AGT","SLAMF8","RFK","CYBA"]} {"pathway":"GO_DNA_METHYLATION_INVOLVED_IN_GAMETE_GENERATION","pval":0.4325,"padj":0.90066,"ES":0.91903,"NES":1.17388,"nMoreExtreme":24169,"size":9,"leadingEdge":["PIWIL4","TDRD9","KDM1B","MOV10L1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE","pval":0.31155,"padj":0.86489,"ES":0.91878,"NES":1.17387,"nMoreExtreme":18512,"size":15,"leadingEdge":["TNF","STX3","FCER1G","TYROBP"]} {"pathway":"GO_HYPERSENSITIVITY","pval":0.43343,"padj":0.90066,"ES":0.91886,"NES":1.17367,"nMoreExtreme":24221,"size":9,"leadingEdge":["HLA-E","C3","GATA3","FCER1G","BTK"]} {"pathway":"GO_CELLULAR_CHEMICAL_HOMEOSTASIS","pval":0.0485,"padj":0.5476,"ES":0.64573,"NES":1.17364,"nMoreExtreme":4733,"size":593,"leadingEdge":["ATP1B2","CD40","P2RX7","LRRK2","CXCL11","CD38","CXCL10","CCL13","ATP13A2","SLC31A2","CXCL9","JAK2","AGT","CCL7","KCNJ2","MCOLN2","CAMK2D","ICAM1","SIDT2","CCL15","TGM2","PML","SRI","CCL8","CCRL2","P2RX4","RAB20","EDN1","SCO2","ANK2","DGAT2","MT2A","SLAMF8","PTGER4","CCL5","LYN","MT1M","JPH4","PTGER2","SLC8A1","CUL1","GPR18","F2RL2","MT1E","CCR5","CCL1","CXCL12","PTPRC","SLC4A10","FPR2","ACKR4","GCLC","TGFB1","KCNMA1","CCL19","CCR6","UCP2","MT1H","ATP6V1A","PDGFRA","C19orf12","P2RY2","GRINA","PKHD1","LPAR1","GAS6","CCL3","CX3CL1","CKB","MT1G","LIN28A","HERPUD1","PLCB1","CLIC2","SLC8A2","NADK","SMAD3","RAB38","RAB39A"]} {"pathway":"GO_PYRIMIDINE_NUCLEOSIDE_CATABOLIC_PROCESS","pval":0.34034,"padj":0.87818,"ES":0.90736,"NES":1.17342,"nMoreExtreme":20566,"size":17,"leadingEdge":["DPYS","TYMP","APOBEC3D","APOBEC3A","APOBEC3G","APOBEC3F"]} {"pathway":"GO_REGULATION_OF_HISTONE_H3_K14_ACETYLATION","pval":0.57956,"padj":0.94163,"ES":0.85302,"NES":1.1734,"nMoreExtreme":30666,"size":5,"leadingEdge":["GATA3","SIRT1"]} {"pathway":"GO_RESPONSE_TO_GAMMA_RADIATION","pval":0.21713,"padj":0.80167,"ES":0.76832,"NES":1.17329,"nMoreExtreme":15371,"size":52,"leadingEdge":["CXCL10","CCL7","PML","TMEM109","POLB","PTPRC","LIG4","GATA3","BAK1"]} {"pathway":"GO_PRIMARY_MIRNA_PROCESSING","pval":0.38116,"padj":0.89036,"ES":0.92403,"NES":1.17309,"nMoreExtreme":21514,"size":10,"leadingEdge":["SMAD3","SRRT"]} {"pathway":"GO_PIGMENT_GRANULE_MATURATION","pval":0.3816,"padj":0.89036,"ES":0.92397,"NES":1.17301,"nMoreExtreme":21539,"size":10,"leadingEdge":["RAB38","AP3D1"]} {"pathway":"GO_SPERM_CAPACITATION","pval":0.32417,"padj":0.86994,"ES":0.92627,"NES":1.17295,"nMoreExtreme":18698,"size":12,"leadingEdge":["CCR6","SPINK1","PRKACA"]} {"pathway":"GO_MONOVALENT_INORGANIC_CATION_TRANSPORT","pval":0.09336,"padj":0.66429,"ES":0.65594,"NES":1.17289,"nMoreExtreme":8706,"size":337,"leadingEdge":["ATP1B2","P2RX7","KCNJ10","SLC12A3","KCNJ2","CAMK2D","SPTBN4","VPS9D1","KCNJ15","P2RX4","SLC2A6","C15orf48","ANK2","KCNE5","RNF207","SLC8A1","HPN","SCN9A","SLC12A7","SLC4A10","KCNE1","P2RY12","TGFB1","KCNMA1","UCP2","ATP6V1A","CLCN4","HVCN1","ACTN2","MIR212","SLC8A2","GLRX","KCNE1B","STOM","SIK1"]} {"pathway":"GO_NAD_BIOSYNTHETIC_PROCESS","pval":0.28986,"padj":0.85125,"ES":0.85945,"NES":1.17284,"nMoreExtreme":18464,"size":25,"leadingEdge":["IDO1","IDO2","PARP10","PARP9","KYNU","KMO","NAMPT","PTGS2"]} {"pathway":"GO_RESPONSE_TO_INORGANIC_SUBSTANCE","pval":0.07231,"padj":0.62163,"ES":0.64958,"NES":1.17268,"nMoreExtreme":6915,"size":442,"leadingEdge":["IL18BP","P2RX7","LRRK2","GCH1","HGF","ATP13A2","STAT1","SUCNR1","CAMK2D","VCAM1","CYP1A1","ICAM1","KLF4","B2M","S100A13","ZC3H12A","P2RX4","EDN1","NCF1","MT2A","NR4A3","SOD2","TNFAIP3","IL6","TXN","MT1M","TNF","SLC8A1","MT1E","SMPD3","ASCL1","GUCA1A","GCLC","SRC","KCNMA1","SYT5","CCL19","UCP2","TXNIP","PRDX1","MT1H","HVCN1","LIG4","PTGS2","GUCY1B1","CFLAR","MT1G","NFE2L2","SYT17","BAK1","IL1A"]} {"pathway":"GO_POSITIVE_REGULATION_OF_HEMOPOIESIS","pval":0.14742,"padj":0.7508,"ES":0.68425,"NES":1.17253,"nMoreExtreme":12450,"size":158,"leadingEdge":["CD74","SOCS1","IL12RB1","IL15","STAT1","RIPK2","FLT3LG","CD80","CYLD","SCIN","BTN2A2","HLA-G","BCL6","CSF1","IL7","CD83","LILRB4","EGR3","TNF","DUSP10","CD86","RASGRP1","PTPRC","STAT3","RUNX1","TGFB1","OCSTAMP","IL2RA","CCL19","ISG15","GAS6","FOXC1","GATA3","PPARGC1B"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY","pval":0.35411,"padj":0.88843,"ES":0.90026,"NES":1.17246,"nMoreExtreme":21544,"size":18,"leadingEdge":["LRRK2","PTPN1","GRINA","HERPUD1"]} {"pathway":"GO_OTIC_VESICLE_MORPHOGENESIS","pval":0.51928,"padj":0.92533,"ES":0.90836,"NES":1.17243,"nMoreExtreme":28612,"size":8,"leadingEdge":["FGF10","PROX1","FGFR2"]} {"pathway":"GO_MESENCHYMAL_TO_EPITHELIAL_TRANSITION_INVOLVED_IN_METANEPHROS_MORPHOGENESIS","pval":0.44281,"padj":0.90221,"ES":0.91772,"NES":1.1722,"nMoreExtreme":24745,"size":9,"leadingEdge":["STAT1","SALL1"]} {"pathway":"GO_REGULATION_OF_TRANSLATION_IN_RESPONSE_TO_STRESS","pval":0.35533,"padj":0.88844,"ES":0.89993,"NES":1.17203,"nMoreExtreme":21618,"size":18,"leadingEdge":["EIF2AK2","NCK2"]} {"pathway":"GO_AMYLOID_BETA_FORMATION","pval":0.27922,"padj":0.84181,"ES":0.84843,"NES":1.17193,"nMoreExtreme":17953,"size":27,"leadingEdge":["GSAP","HAP1"]} {"pathway":"GO_TRIGLYCERIDE_RICH_LIPOPROTEIN_PARTICLE_CLEARANCE","pval":0.57994,"padj":0.94163,"ES":0.85194,"NES":1.17191,"nMoreExtreme":30686,"size":5,"leadingEdge":["LMF1","LDLR"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY","pval":0.18786,"padj":0.78227,"ES":0.72084,"NES":1.17173,"nMoreExtreme":14448,"size":88,"leadingEdge":["CD74","LRRK2","BCL2A1","MUC1","SOD2","CXCL12","SRC","PTPN1","GRINA","MCL1","PTGS2","NFE2L2","HERPUD1"]} {"pathway":"GO_REGULATION_OF_MYOBLAST_FUSION","pval":0.33623,"padj":0.87588,"ES":0.91189,"NES":1.17147,"nMoreExtreme":20140,"size":16,"leadingEdge":["CXCL10","CXCL9","FLT3LG","ADGRB1","RIPOR2","CFLAR","CD53","FLOT1","EHD1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_LIPID_LOCALIZATION","pval":0.26529,"padj":0.83566,"ES":0.83406,"NES":1.17144,"nMoreExtreme":17293,"size":30,"leadingEdge":["TTC39B","IL6","TNF","NR1H3","PTPN2","NFKBIA","CRY1"]} {"pathway":"GO_REGULATION_OF_ORGANELLE_TRANSPORT_ALONG_MICROTUBULE","pval":0.52424,"padj":0.92669,"ES":0.90757,"NES":1.17142,"nMoreExtreme":28885,"size":8,"leadingEdge":["MAP2","TRIM46","HAP1","NEFH"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_LIPASE_ACTIVITY","pval":0.32152,"padj":0.86901,"ES":0.92049,"NES":1.17141,"nMoreExtreme":18924,"size":14,"leadingEdge":["ANGPTL4","SORT1","HDAC9"]} {"pathway":"GO_RNA_SPLICING_VIA_ENDONUCLEOLYTIC_CLEAVAGE_AND_LIGATION","pval":0.33718,"padj":0.87681,"ES":0.91175,"NES":1.17129,"nMoreExtreme":20197,"size":16,"leadingEdge":["TSEN34","CPSF1"]} {"pathway":"GO_NEUROTRANSMITTER_GATED_ION_CHANNEL_CLUSTERING","pval":0.44909,"padj":0.90517,"ES":0.91684,"NES":1.17108,"nMoreExtreme":25096,"size":9,"leadingEdge":["SHISA7","SSH1"]} {"pathway":"GO_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS","pval":0.27513,"padj":0.83772,"ES":0.84269,"NES":1.17108,"nMoreExtreme":17772,"size":28,"leadingEdge":["RFK","CAD"]} {"pathway":"GO_REGULATION_OF_EXOSOMAL_SECRETION","pval":0.3274,"padj":0.87112,"ES":0.91657,"NES":1.17105,"nMoreExtreme":19454,"size":15,"leadingEdge":["ATP13A2","SMPD3","TSG101"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE","pval":0.32339,"padj":0.86974,"ES":0.9202,"NES":1.17105,"nMoreExtreme":19034,"size":14,"leadingEdge":["IDO1","CD74","NOD2","RSAD2","IL6","CD86","GATA3","IL33"]} {"pathway":"GO_PROTEIN_CATABOLIC_PROCESS_IN_THE_VACUOLE","pval":0.32359,"padj":0.86974,"ES":0.92018,"NES":1.17102,"nMoreExtreme":19046,"size":14,"leadingEdge":["ATP13A2","LAMP2"]} {"pathway":"GO_PURINE_NUCLEOSIDE_METABOLIC_PROCESS","pval":0.25513,"padj":0.82758,"ES":0.82073,"NES":1.17101,"nMoreExtreme":16864,"size":33,"leadingEdge":["LRRK2","GIMAP7","GTPBP1","RHOQ","ACPP","AK4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION","pval":0.22191,"padj":0.80586,"ES":0.76848,"NES":1.17098,"nMoreExtreme":15676,"size":51,"leadingEdge":["SOCS1","IL12RB1","HLA-E","RIPK2","CD80","IL12A","CD83","EBI3","CD86","PTPRC","RUNX1","CCL19"]} {"pathway":"GO_REGULATION_OF_MONOCYTE_CHEMOTAXIS","pval":0.3245,"padj":0.86994,"ES":0.88083,"NES":1.17096,"nMoreExtreme":20195,"size":21,"leadingEdge":["CXCL10","SLAMF8","CCL5","LYN","CCL1","CXCL12","FPR2","SLIT2","CCR1"]} {"pathway":"GO_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING","pval":0.35665,"padj":0.88903,"ES":0.92469,"NES":1.17094,"nMoreExtreme":20364,"size":11,"leadingEdge":["LIPG","SCARB1"]} {"pathway":"GO_GALACTOSE_CATABOLIC_PROCESS","pval":0.4516,"padj":0.90517,"ES":0.9165,"NES":1.17065,"nMoreExtreme":25236,"size":9,"leadingEdge":["GALM","PGM1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CALCIUM_ION_IMPORT","pval":0.35849,"padj":0.89036,"ES":0.92442,"NES":1.1706,"nMoreExtreme":20469,"size":11,"leadingEdge":["CXCL12","CCL2","CCL3","PDGFB","CASR"]} {"pathway":"GO_POSITIVE_REGULATION_OF_METANEPHROS_DEVELOPMENT","pval":0.35967,"padj":0.89036,"ES":0.92425,"NES":1.17039,"nMoreExtreme":20536,"size":11,"leadingEdge":["PDGFB","PDGFRB"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MYOTUBE_DIFFERENTIATION","pval":0.3965,"padj":0.89503,"ES":0.92189,"NES":1.17037,"nMoreExtreme":22380,"size":10,"leadingEdge":["CXCL10","BHLHE41","TRIM72","CFLAR","HDAC4"]} {"pathway":"GO_INTERLEUKIN_23_MEDIATED_SIGNALING_PATHWAY","pval":0.53188,"padj":0.92816,"ES":0.90654,"NES":1.17008,"nMoreExtreme":29306,"size":8,"leadingEdge":["IL12RB1","JAK2","STAT3","STAT4"]} {"pathway":"GO_INTRACELLULAR_TRANSPORT","pval":0.0037,"padj":0.14766,"ES":0.63843,"NES":1.16997,"nMoreExtreme":369,"size":1645,"leadingEdge":["TAP2","TAP1","CD74","P2RX7","LRRK2","STX11","ATP13A2","EGR2","LMTK2","GRIN3A","AGT","IFI27","ERC2","SPTBN4","RTP4","PRRT2","PML","S100A13","ZC3H12A","ACOT4","RAB20","USP6NL","NCF1","DTX3L","RHOBTB3","ANK2","NUCB1","DOP1A","GSTK1","CHMP4C","ZDHHC19","DYNLT1","KPNA5","LYN","DTNBP1","TICAM2","CADPS2","NR4A3","DENND1B","EDEM1","CTSZ","TXN","AP5B1","ZDHHC18","RASGRP1","RAB24","NTN1","ZDHHC11B","ATG3","KCNE1","STAT3","PAK1","TRIM9","SRC","TGFB1","TBC1D2B","SYT5","CCDC88B","SNX16","AKAP12","TXNIP","CTSC","PTPN1","SORT1","ACTN2","MAP2","PTGS2","GAS6","PARL","CES1","AP1AR","SNX8","DNAJC13","HERPUD1","RILPL1","NAPA","SMAD3","RAB38","STX3","SYT17","LMF1","RAB39A","DENND5A","SPTA1","STX17","STOM","PRR5L","RAB11FIP4","FCER1G","NCOA4","TRIM46","ARC","ZDHHC23","GCC2","CPT1A","NPC1","XPO6","RUFY3"]} {"pathway":"GO_IMMUNOGLOBULIN_SECRETION","pval":0.36135,"padj":0.89036,"ES":0.89825,"NES":1.16984,"nMoreExtreme":21984,"size":18,"leadingEdge":["CD40","HLA-E","TNFSF13B","IL6","TNF","IL33"]} {"pathway":"GO_POSITIVE_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS","pval":0.29383,"padj":0.85391,"ES":0.85724,"NES":1.16982,"nMoreExtreme":18717,"size":25,"leadingEdge":["IDO1","P2RX7","CD274","HCAR2","PDCD1","RAPGEF2","CCL5","LYN","NR4A3","PRELID1"]} {"pathway":"GO_REGULATION_OF_MICROTUBULE_BINDING","pval":0.39957,"padj":0.89503,"ES":0.92139,"NES":1.16973,"nMoreExtreme":22553,"size":10,"leadingEdge":["MAP2","GAS8","MARK2"]} {"pathway":"GO_ACTIN_POLYMERIZATION_OR_DEPOLYMERIZATION","pval":0.14173,"padj":0.73885,"ES":0.67558,"NES":1.1697,"nMoreExtreme":12215,"size":184,"leadingEdge":["PSTPIP2","PLEK","MSRB1","JAK2","SPTBN4","ICAM1","SCIN","TMSB10","FAM107A","CXCL12","ACTR3C","CDC42EP2","ACTN2","AP1AR","SPTA1","SLIT2"]} {"pathway":"GO_REGULATION_OF_RESTING_MEMBRANE_POTENTIAL","pval":0.59592,"padj":0.94465,"ES":0.89416,"NES":1.16963,"nMoreExtreme":32391,"size":7,"leadingEdge":["KCNJ10","KCNJ2","PSEN1"]} {"pathway":"GO_REGULATION_OF_HAIR_FOLLICLE_DEVELOPMENT","pval":0.34532,"padj":0.88254,"ES":0.91042,"NES":1.16958,"nMoreExtreme":20685,"size":16,"leadingEdge":["TNF","FST","CDH3"]} {"pathway":"GO_PROGRAMMED_CELL_DEATH_IN_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES","pval":0.36492,"padj":0.89036,"ES":0.92359,"NES":1.16956,"nMoreExtreme":20836,"size":11,"leadingEdge":["HGF","MET"]} {"pathway":"GO_T_HELPER_17_CELL_LINEAGE_COMMITMENT","pval":0.3652,"padj":0.89036,"ES":0.92353,"NES":1.16948,"nMoreExtreme":20852,"size":11,"leadingEdge":["IL12RB1","TBX21","SLAMF6","IRF4","IL6","STAT3"]} {"pathway":"GO_REGULATION_OF_T_HELPER_1_CELL_DIFFERENTIATION","pval":0.40235,"padj":0.89503,"ES":0.92106,"NES":1.16932,"nMoreExtreme":22710,"size":10,"leadingEdge":["RIPK2","IL27","CD80","JAK3","CCL19","HLX"]} {"pathway":"GO_REGULATION_OF_MYD88_INDEPENDENT_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY","pval":0.5368,"padj":0.92816,"ES":0.90583,"NES":1.16917,"nMoreExtreme":29577,"size":8,"leadingEdge":["IRF7","TICAM2","TLR3","TLR4","TICAM1","SARM1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL","pval":0.19972,"padj":0.79183,"ES":0.73143,"NES":1.16913,"nMoreExtreme":14996,"size":75,"leadingEdge":["PARP10","DTX3L","DYSF","TNFAIP3","SPOPL","GCLC","TRIM21","ADGRB1","ISG15","LIMK1","MAGEA2"]} {"pathway":"GO_DNA_DEALKYLATION","pval":0.28295,"padj":0.84565,"ES":0.84632,"NES":1.16902,"nMoreExtreme":18193,"size":27,"leadingEdge":["APOBEC3D","APOBEC3A","APOBEC3G","APOBEC3F","OTUD4","GATA3"]} {"pathway":"GO_DETECTION_OF_BIOTIC_STIMULUS","pval":0.36004,"padj":0.89036,"ES":0.90387,"NES":1.16891,"nMoreExtreme":21756,"size":17,"leadingEdge":["C4B","NOD2","TLR4","TLR1"]} {"pathway":"GO_GAMMA_AMINOBUTYRIC_ACID_TRANSPORT","pval":0.46203,"padj":0.90517,"ES":0.91501,"NES":1.16874,"nMoreExtreme":25819,"size":9,"leadingEdge":["SLC6A12","P2RX7"]} {"pathway":"GO_MODULATION_OF_GROWTH_OF_SYMBIONT_INVOLVED_IN_INTERACTION_WITH_HOST","pval":0.46206,"padj":0.90517,"ES":0.91499,"NES":1.16871,"nMoreExtreme":25821,"size":9,"leadingEdge":["LTA","TNF","IRF8"]} {"pathway":"GO_HISTONE_H3_DEACETYLATION","pval":0.36121,"padj":0.89036,"ES":0.9037,"NES":1.16869,"nMoreExtreme":21827,"size":17,"leadingEdge":["HDAC4","HDAC9"]} {"pathway":"GO_POSITIVE_REGULATION_OF_VIRAL_TRANSCRIPTION","pval":0.24075,"padj":0.82355,"ES":0.79203,"NES":1.16866,"nMoreExtreme":16453,"size":41,"leadingEdge":["HPN","GTF2B","POLR2J"]} {"pathway":"GO_CELLULAR_ION_HOMEOSTASIS","pval":0.06999,"padj":0.61798,"ES":0.64576,"NES":1.16857,"nMoreExtreme":6740,"size":485,"leadingEdge":["ATP1B2","CD40","P2RX7","LRRK2","CXCL11","CD38","CXCL10","CCL13","ATP13A2","SLC31A2","CXCL9","JAK2","AGT","CCL7","KCNJ2","MCOLN2","CAMK2D","CCL15","TGM2","PML","SRI","CCL8","CCRL2","P2RX4","RAB20","EDN1","SCO2","ANK2","MT2A","SLAMF8","PTGER4","CCL5","LYN","MT1M","JPH4","PTGER2","SLC8A1","CUL1","GPR18","F2RL2","MT1E","CCR5","CCL1","CXCL12","PTPRC","SLC4A10","FPR2","ACKR4","TGFB1","KCNMA1","CCL19","CCR6","MT1H","ATP6V1A","PDGFRA","C19orf12","P2RY2","GRINA","PKHD1","LPAR1","CCL3","CX3CL1","CKB","MT1G","HERPUD1","PLCB1","CLIC2","SLC8A2","SMAD3","RAB38","RAB39A"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_VOLTAGE_GATED_POTASSIUM_CHANNEL_ACTIVITY","pval":0.40685,"padj":0.89503,"ES":0.92043,"NES":1.16852,"nMoreExtreme":22964,"size":10,"leadingEdge":["KCNE5","KCNE1","MIR212","KCNE1B"]} {"pathway":"GO_REGULATION_OF_TOLL_LIKE_RECEPTOR_3_SIGNALING_PATHWAY","pval":0.46308,"padj":0.90517,"ES":0.91482,"NES":1.1685,"nMoreExtreme":25878,"size":9,"leadingEdge":["TNFAIP3","WDFY1","FLOT1"]} {"pathway":"GO_MEMBRANE_RAFT_ASSEMBLY","pval":0.46344,"padj":0.90527,"ES":0.91476,"NES":1.16843,"nMoreExtreme":25898,"size":9,"leadingEdge":["S100A10","FLOT1","PACSIN2"]} {"pathway":"GO_CELLULAR_AMIDE_METABOLIC_PROCESS","pval":0.02953,"padj":0.43049,"ES":0.63955,"NES":1.16824,"nMoreExtreme":2926,"size":832,"leadingEdge":["P2RX7","GSAP","BANK1","TAPBP","ACSL1","XRN1","SAMD4A","ZC3H12A","ACOT4","MTHFD2","PPA1","GTPBP1","CNDP2","PIWIL4","MIR503","GSTK1","DGAT2","CTNS","GGT5","CCL5","CHAC1","DNPEP","B4GALT5","IL6","TNF","SMPD3","MOV10","ACSL5","PTAFR","ST3GAL5","ELOVL7","PSEN2","STAT3","TRIM71","GCLC","ACSS1","ACSM5","NFE2L2","LIN28A","MIR212"]} {"pathway":"GO_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS_IN_THE_VACUOLE","pval":0.40857,"padj":0.89503,"ES":0.92018,"NES":1.1682,"nMoreExtreme":23061,"size":10,"leadingEdge":["ATP13A2","VPS35"]} {"pathway":"GO_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE_MEDIATED_BY_CIRCULATING_IMMUNOGLOBULIN","pval":0.59681,"padj":0.94558,"ES":0.89273,"NES":1.16776,"nMoreExtreme":32439,"size":7,"leadingEdge":["LTA","TNF","PTPRC","FCGR2B"]} {"pathway":"GO_MESENCHYMAL_CELL_APOPTOTIC_PROCESS","pval":0.54487,"padj":0.93088,"ES":0.90465,"NES":1.16765,"nMoreExtreme":30022,"size":8,"leadingEdge":["TBX1","HNF1B","HIF1A"]} {"pathway":"GO_DNA_METHYLATION_OR_DEMETHYLATION","pval":0.2088,"padj":0.79637,"ES":0.74018,"NES":1.16763,"nMoreExtreme":15400,"size":67,"leadingEdge":["APOBEC3D","APOBEC3A","APOBEC3G","PIWIL4","TDRD9","APOBEC3F","OTUD4","GATA3","KDM1B"]} {"pathway":"GO_PROTEASOMAL_UBIQUITIN_INDEPENDENT_PROTEIN_CATABOLIC_PROCESS","pval":0.32841,"padj":0.87191,"ES":0.87818,"NES":1.16744,"nMoreExtreme":20438,"size":21,"leadingEdge":["PSMB9","PSMB10","PSMB8","PSMA4","PSMA2","PSMA5","NFE2L2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION","pval":0.17106,"padj":0.77295,"ES":0.69465,"NES":1.16744,"nMoreExtreme":13912,"size":124,"leadingEdge":["CD74","SOCS1","IL12RB1","IL15","RIPK2","FLT3LG","CD80","CYLD","BTN2A2","HLA-G","BCL6","CSF1","IL7","CD83","LILRB4","EGR3","TNF","DUSP10","CD86","RASGRP1","PTPRC","RUNX1","TGFB1","OCSTAMP","IL2RA","CCL19","GAS6","GATA3","PPARGC1B"]} {"pathway":"GO_POSITIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS","pval":0.18487,"padj":0.77988,"ES":0.70639,"NES":1.16735,"nMoreExtreme":14611,"size":103,"leadingEdge":["NOD2","AGT","DGAT2","LYN","NR4A3","TNF","FLT1","SMPD3","NR1H3","FPR2","P2RY12","SRC","TGFB1","CCL19","PDGFRA","PTGS2","PDGFB","RAB38","AGAP2","CPT1A","LPGAT1"]} {"pathway":"GO_RNA_METABOLIC_PROCESS","pval":0.01998,"padj":0.36056,"ES":0.63799,"NES":1.16722,"nMoreExtreme":1988,"size":1006,"leadingEdge":["ISG20","XRN1","APOBEC3D","APOBEC3A","APOBEC3G","ZC3H12A","TMTC1","PPA1","PIWIL4","TDRD9","OAS2","OAS3","APOBEC3F","RBM11","HELZ2","MOV10","STAT3","TRIM71","TGFB1","ELAVL4","ADAR","RRAGC","CCNL1","PRPF3","LIN28A","CIR1","ERI1","SMAD3","OASL","SEPHS2","TSEN34","EREG","SNORD89"]} {"pathway":"GO_REGULATION_OF_NUCLEOTIDE_BINDING_OLIGOMERIZATION_DOMAIN_CONTAINING_SIGNALING_PATHWAY","pval":0.47058,"padj":0.9079,"ES":0.91381,"NES":1.16721,"nMoreExtreme":26297,"size":9,"leadingEdge":["TNFAIP3","BIRC3","TLR4"]} {"pathway":"GO_WOUND_HEALING","pval":0.08629,"padj":0.65271,"ES":0.6481,"NES":1.16709,"nMoreExtreme":8196,"size":407,"leadingEdge":["IRF1","CD40","P2RX7","SERPING1","CEACAM1","PLEK","JAK2","MYOF","ENPP4","TSPAN32","P2RX4","EDN1","MAFF","COMP","DYSF","LYN","DTNBP1","PLSCR1","TNFAIP3","IL6","FGF10","PROCR","DGKG","DUSP10","TRIM72","F2RL2","LCP2","F3","SH2B2","P2RY12","PAK1","SRC","TGFB1","A2M","CDKN1A","GP1BA","PDGFRA","GAS6","CX3CL1","CFLAR","GATA3","IRF2","NFE2L2","PDGFB","SMAD3","IL1A","MYOZ1","FCER1G"]} {"pathway":"GO_MAINTENANCE_OF_PROTEIN_LOCATION","pval":0.19006,"padj":0.78784,"ES":0.71366,"NES":1.16708,"nMoreExtreme":14763,"size":93,"leadingEdge":["SPTBN4","PML","SRI","SCIN","TMSB10","TXN","NFKBIA","NFKBIE"]} {"pathway":"GO_ION_HOMEOSTASIS","pval":0.05553,"padj":0.56688,"ES":0.64203,"NES":1.16692,"nMoreExtreme":5419,"size":593,"leadingEdge":["ATP1B2","CD40","P2RX7","LRRK2","SNX10","CXCL11","CD38","CXCL10","CCL13","ATP13A2","SLC31A2","CXCL9","KCNJ10","JAK2","AGT","STEAP4","SLC12A3","CCL7","KCNJ2","MCOLN2","CAMK2D","CCL15","TGM2","PML","FAM20A","SRI","B2M","CCL8","CCRL2","P2RX4","RAB20","NPR1","EDN1","SCO2","SLC25A28","ANK2","DGAT2","MT2A","SLAMF8","PTGER4","CCL5","LYN","MT1M","JPH4","PTGER2","SLC8A1","CUL1","GPR18","F2RL2","MT1E","CCR5","CCL1","SLC12A7","CXCL12","CYP27B1","PTPRC","SLC4A10","LIPG","FPR2","ACKR4","TMTC2","GCLC","SRC","TGFB1","KCNMA1","CCL19","CCR6","MT1H","ATP6V1A","PDGFRA","C19orf12","P2RY2","IFI6","GRINA","PKHD1","LPAR1","CCL3","CX3CL1","CKB","MT1G","HERPUD1","PLCB1","CLIC2","SLC8A2","SMAD3","RAB38"]} {"pathway":"GO_OLIGODENDROCYTE_DEVELOPMENT","pval":0.25799,"padj":0.82758,"ES":0.81395,"NES":1.16689,"nMoreExtreme":17126,"size":34,"leadingEdge":["KCNJ10","LYN","B4GALT5","ASCL1","TGFB1","LPAR1"]} {"pathway":"GO_SREBP_SIGNALING_PATHWAY","pval":0.47285,"padj":0.90882,"ES":0.91347,"NES":1.16678,"nMoreExtreme":26424,"size":9,"leadingEdge":["ERLIN1","INSIG2","ARHGEF10L"]} {"pathway":"GO_SEROTONIN_TRANSPORT","pval":0.41806,"padj":0.89503,"ES":0.91886,"NES":1.16652,"nMoreExtreme":23597,"size":10,"leadingEdge":["SLC18A1","LILRB1","GPM6B","FCER1G"]} {"pathway":"GO_PEPTIDYL_LYSINE_DEACETYLATION","pval":0.55079,"padj":0.93215,"ES":0.90375,"NES":1.16649,"nMoreExtreme":30348,"size":8,"leadingEdge":["HDAC4","HDAC9"]} {"pathway":"GO_PROTEIN_DNA_COMPLEX_DISASSEMBLY","pval":0.37061,"padj":0.89036,"ES":0.90179,"NES":1.16622,"nMoreExtreme":22395,"size":17,"leadingEdge":["SMARCD3","SMARCD1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION","pval":0.2355,"padj":0.81978,"ES":0.77636,"NES":1.16619,"nMoreExtreme":16391,"size":46,"leadingEdge":["CD274","ZC3H12A","SLAMF1","TNFAIP3","LILRA4","GPR18","LILRB1","GAS6","CX3CL1","TLR4","ORM1"]} {"pathway":"GO_REGULATION_OF_BODY_FLUID_LEVELS","pval":0.09934,"padj":0.66778,"ES":0.6507,"NES":1.16597,"nMoreExtreme":9317,"size":353,"leadingEdge":["IRF1","CD40","P2RX7","SERPING1","CEACAM1","PLEK","JAK2","ENPP4","TSPAN32","P2RX4","NPR1","EDN1","MAFF","COMP","LYN","OAS2","TIFAB","DTNBP1","PLSCR1","IL6","FGF10","STAT5A","PROCR","DGKG","F2RL2","NCOA1","LCP2","NR1H3","F3","SH2B2","P2RY12","SRC","A2M","GP1BA","PDGFRA","P2RY2","HAS2","GAS6","GATA3","IRF2","NFE2L2"]} {"pathway":"GO_INTRACELLULAR_MRNA_LOCALIZATION","pval":0.36446,"padj":0.89036,"ES":0.9207,"NES":1.16591,"nMoreExtreme":21022,"size":12,"leadingEdge":["ZFP36","EXOSC3"]} {"pathway":"GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_ENDOGENOUS_ANTIGEN","pval":0.34103,"padj":0.87818,"ES":0.88309,"NES":1.16586,"nMoreExtreme":21080,"size":20,"leadingEdge":["TAP2","TAP1","CD74","ERAP2","HLA-F","HLA-B","HLA-E","HLA-A","HLA-C","TAPBP","B2M","HLA-G"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_PHAGOPHORE_ASSEMBLY_SITE","pval":0.36564,"padj":0.89036,"ES":0.92054,"NES":1.16569,"nMoreExtreme":21090,"size":12,"leadingEdge":["STX17","WIPI1"]} {"pathway":"GO_REGULATION_OF_CHOLESTEROL_METABOLIC_PROCESS","pval":0.38692,"padj":0.89277,"ES":0.92053,"NES":1.16567,"nMoreExtreme":22092,"size":11,"leadingEdge":["TTC39B","DGAT2","LMF1","ACADVL"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MEMBRANE_POTENTIAL","pval":0.36669,"padj":0.89036,"ES":0.92037,"NES":1.16548,"nMoreExtreme":21151,"size":12,"leadingEdge":["CTNS","GLRX","BAD"]} {"pathway":"GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR","pval":0.28778,"padj":0.84886,"ES":0.84372,"NES":1.16543,"nMoreExtreme":18503,"size":27,"leadingEdge":["CD74","MUC1","KDM1A"]} {"pathway":"GO_VASCULAR_SMOOTH_MUSCLE_CELL_DIFFERENTIATION","pval":0.30561,"padj":0.86234,"ES":0.85921,"NES":1.16531,"nMoreExtreme":19354,"size":24,"leadingEdge":["COMP","SOD2","PDGFB","NFATC1"]} {"pathway":"GO_PHOSPHATIDYLETHANOLAMINE_ACYL_CHAIN_REMODELING","pval":0.35599,"padj":0.88877,"ES":0.91558,"NES":1.16516,"nMoreExtreme":20953,"size":14,"leadingEdge":["PLAAT4","PLAAT3","PLA2G4C","PLA2G4A"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CHEMOKINE_BIOSYNTHETIC_PROCESS","pval":0.42756,"padj":0.89886,"ES":0.91772,"NES":1.16507,"nMoreExtreme":24133,"size":10,"leadingEdge":["TLR3","TNF","TICAM1"]} {"pathway":"GO_T_HELPER_1_TYPE_IMMUNE_RESPONSE","pval":0.25194,"padj":0.82744,"ES":0.79834,"NES":1.16483,"nMoreExtreme":17035,"size":38,"leadingEdge":["IL18BP","IL12RB1","RIPK2","IL27","CD80","JAK3","RELB","EBI3","SEMA4A","CCL19","IL33","HLX","TLR4","IL18RAP"]} {"pathway":"GO_REGULATION_OF_TRANSPORT","pval":0.00828,"padj":0.24017,"ES":0.63578,"NES":1.16479,"nMoreExtreme":826,"size":1394,"leadingEdge":["ATP1B2","IL15RA","AIM2","CD40","GBP1","C4A","CD74","P2RX7","SOCS1","CD274","LRRK2","CXCL11","C4B","CD38","IL15","PDE4B","CXCL10","NOD2","HLA-F","CEACAM1","CLEC9A","ATP13A2","SLC31A2","HLA-E","BANK1","CXCL9","GRIN3A","KCNJ10","HCAR2","JAK2","AGT","IFI27","RIPK2","TLR8","C2","KCNJ2","CAMK2D","SPTBN4","ICAM1","SIDT2","CLEC6A","KCNJ15","GSDMD","PRRT2","PML","SRI","B2M","C3","CD300LF","RASGRF1","TLR10","ZC3H12A","ABCB1","CTSS","P2RX4","CARD17","STAP1","RAB20","SCIN","MCTP2","CARD16","NPR1","RSAD2","TMEM109","RALB","BTN2A2","EDN1","VEGFC","IFIH1","PMAIP1","LILRA2","ANK2","NUCB1","TTC39B","CLIC5","DYSF","PTGER4","CCL5","LYN","OAS2","TIFAB","DTNBP1","GLUL","SYNGR3","CADPS2","NR4A3","TNFRSF14","KCNE5","TNFAIP3","ANXA3","EDEM1","RNF207","STAC3","IL6","CLEC4E","FGF10","IL2RG","TXN","RSC1A1","JPH4","TNF","SLC8A1","CD47","RASGRP1","SCN9A","CAMK1D","AZIN2","SMPD3","CCL1","CXCL12","GEM","PTPRC","LIPG","PTAFR","ATG3","DDX58","CCL4","NR1H3","LILRB1","KCNE1","PSEN2","CCL2","KMO","CACNA1I","P2RY12","PAK1","TRIM9","SRC","TGFB1","KCNMA1","SYT5","CCL19","SNX16","UCP2","RHBDF2","PTPN1","HVCN1","P2RY2","RHOQ","NFKBIA","ACTN2","MAP2","GPM6B","PTGS2","GAS6","PARL","CCL3","CX3CL1","PRELID1","RGS9","GATA3","CASP1","NKX3-1","NFE2L2","SRCIN1","IL33","MIR212","ANKRD13A","DNAJC13","SPINK1","BBC3","CLIC2","NADK","IL1R2","PDGFB","NAPA","SMAD3","SYT17","ILDR1","GLRX","KCNE1B","BAK1","IL1A","STOM","PRR5L","SIK1","FCER1G","TRIM46","LILRA5","SHISA7","EDNRA","S100A1","FLOT1","ARC","TLR4","GCC2","MAPK8IP2","CCR1","CPT1A","KCNMB1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_T_CELL_CYTOKINE_PRODUCTION","pval":0.37602,"padj":0.89036,"ES":0.90068,"NES":1.16478,"nMoreExtreme":22722,"size":17,"leadingEdge":["B2M","RSAD2","IL6","GATA3","PRKCZ"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_INFLAMMATORY_RESPONSE","pval":0.37058,"padj":0.89036,"ES":0.91981,"NES":1.16477,"nMoreExtreme":21375,"size":12,"leadingEdge":["GBP5","NOD2","MYD88","TLR4","TICAM1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR","pval":0.35866,"padj":0.89036,"ES":0.91513,"NES":1.16459,"nMoreExtreme":21110,"size":14,"leadingEdge":["PMAIP1","PYHIN1","HIC1"]} {"pathway":"GO_MACROPHAGE_INFLAMMATORY_PROTEIN_1_ALPHA_PRODUCTION","pval":0.5986,"padj":0.94558,"ES":0.87093,"NES":1.16458,"nMoreExtreme":32126,"size":6,"leadingEdge":["MCOLN2","MEFV","ARG2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CHEMOKINE_PRODUCTION","pval":0.3697,"padj":0.89036,"ES":0.90652,"NES":1.16457,"nMoreExtreme":22145,"size":16,"leadingEdge":["KLF4","MEFV","IL6","ARG2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_COLLATERAL_SPROUTING","pval":0.43144,"padj":0.89981,"ES":0.91717,"NES":1.16438,"nMoreExtreme":24352,"size":10,"leadingEdge":["SEMA4D","NGF","WNT3"]} {"pathway":"GO_CYSTEINE_METABOLIC_PROCESS","pval":0.48866,"padj":0.91689,"ES":0.91139,"NES":1.16412,"nMoreExtreme":27307,"size":9,"leadingEdge":["GCLC","CBSL","GCLM"]} {"pathway":"GO_REGULATION_OF_PROTEASOMAL_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS","pval":0.18107,"padj":0.77555,"ES":0.69675,"NES":1.16409,"nMoreExtreme":14573,"size":116,"leadingEdge":["LRRK2","NUB1","RNF19B","RNF144B","GCLC","NFE2L2","IL33","HERPUD1","RNF19A","PRICKLE1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_LOCOMOTION","pval":0.07985,"padj":0.63856,"ES":0.64408,"NES":1.16402,"nMoreExtreme":7661,"size":460,"leadingEdge":["CD40","CD74","CD274","CXCL10","HGF","JAK2","SUCNR1","AGT","ONECUT2","CCL7","ICAM1","TNFSF18","CCL8","ZC3H12A","P2RX4","RAPGEF2","ENPP2","EDN1","VEGFC","FAM107A","DYSF","GLIPR2","CHMP4C","CCL5","LYN","IL12A","TNFAIP6","CSF1","NR4A3","TNFRSF14","SOD2","ANXA3","CXCL16","IL6","FGF10","SEMA7A","TNF","STAT5A","FLT1","SLC8A1","CAMK1D","CCL1","NTN1","CXCL12","PTPRC","PTAFR","CCL4","FPR2","F3","STAT3","P2RY12","PAK1","PODXL","SRC","TGFB1","SEMA4A","CCL19","CCR6","CXCL8","PDGFRA","LPAR1","PTGS2","RIPOR2","HAS2","GAS6","CCL3","GATA3","NFE2L2","SEMA4D","DAPK2","PDGFB","SMAD3","STX3"]} {"pathway":"GO_CARDIAC_VENTRICLE_FORMATION","pval":0.56249,"padj":0.93517,"ES":0.90184,"NES":1.16402,"nMoreExtreme":30993,"size":8,"leadingEdge":["SMARCD3","MEF2C"]} {"pathway":"GO_SINGLE_STRAND_BREAK_REPAIR","pval":0.5636,"padj":0.93517,"ES":0.90167,"NES":1.1638,"nMoreExtreme":31054,"size":8,"leadingEdge":["LIG4","APLF","TDP1"]} {"pathway":"GO_REGULATION_OF_EXOCYTOSIS","pval":0.15491,"padj":0.75763,"ES":0.67513,"NES":1.16373,"nMoreExtreme":13230,"size":172,"leadingEdge":["LRRK2","HLA-F","CEACAM1","ATP13A2","GRIN3A","RALB","LYN","DTNBP1","CADPS2","RSC1A1","SMPD3","PTAFR","CACNA1I","TRIM9","SYT5","NAPA","SYT17","FCER1G","RAB2B","HAP1","CD84","ADORA2A"]} {"pathway":"GO_REGULATION_OF_PROTEIN_DEPHOSPHORYLATION","pval":0.18009,"padj":0.77529,"ES":0.6949,"NES":1.16369,"nMoreExtreme":14553,"size":119,"leadingEdge":["LMTK2","JAK2","TNF","PTPRC","TGFB1","ELFN1","MYOZ1","PPP1R16B","PTN","LILRB2","EIF2AK2"]} {"pathway":"GO_MESONEPHRIC_TUBULE_FORMATION","pval":0.5642,"padj":0.93517,"ES":0.90156,"NES":1.16366,"nMoreExtreme":31087,"size":8,"leadingEdge":["GATA3","HNF1B","SIX1"]} {"pathway":"GO_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT","pval":0.13163,"padj":0.72756,"ES":0.66171,"NES":1.16355,"nMoreExtreme":11758,"size":238,"leadingEdge":["ATP1B2","CXCL11","PDE4B","CXCL10","SLC31A2","CXCL9","AGT","KCNJ2","CAMK2D","SRI","RASGRF1","CTSS","ANK2","DYSF","LYN","KCNE5","ANXA3","RNF207","STAC3","JPH4","SLC8A1","GEM","KCNE1","PSEN2","TGFB1","ACTN2","CX3CL1","RGS9","MIR212","CLIC2","GLRX","KCNE1B","STOM","SHISA7","S100A1","ARC","MAPK8IP2","KCNMB1"]} {"pathway":"GO_REGULATION_OF_SECONDARY_HEART_FIELD_CARDIOBLAST_PROLIFERATION","pval":0.56493,"padj":0.93517,"ES":0.90145,"NES":1.16351,"nMoreExtreme":31127,"size":8,"leadingEdge":["SIX1","MKS1"]} {"pathway":"GO_SKELETAL_MUSCLE_CELL_PROLIFERATION","pval":0.37758,"padj":0.89036,"ES":0.9188,"NES":1.1635,"nMoreExtreme":21779,"size":12,"leadingEdge":["JAK2","STAT3","CFLAR","SIX1"]} {"pathway":"GO_RETINAL_METABOLIC_PROCESS","pval":0.49214,"padj":0.91907,"ES":0.91088,"NES":1.16348,"nMoreExtreme":27502,"size":9,"leadingEdge":["ALDH1A2","RDH11"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_HIPPO_SIGNALING","pval":0.56529,"padj":0.93517,"ES":0.90139,"NES":1.16344,"nMoreExtreme":31147,"size":8,"leadingEdge":["WWC3","MARK3"]} {"pathway":"GO_CYTOSOLIC_CALCIUM_ION_TRANSPORT","pval":0.17647,"padj":0.77529,"ES":0.6912,"NES":1.16338,"nMoreExtreme":14394,"size":126,"leadingEdge":["P2RX7","CXCL11","CXCL10","CXCL9","MCOLN2","CAMK2D","PML","SRI","P2RX4","ANK2","LYN","JPH4","SLC8A1","CCR5","PTPRC","PSEN2","TGFB1","CCL19","CCL3","CX3CL1","PLCB1","CLIC2","BAK1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_POLYMERIZATION","pval":0.20003,"padj":0.79183,"ES":0.71635,"NES":1.16338,"nMoreExtreme":15371,"size":87,"leadingEdge":["ICAM1","SCIN","ACTR3C","CDC42EP2","AP1AR","BAIAP2L1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MAST_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE","pval":0.37834,"padj":0.89036,"ES":0.91868,"NES":1.16334,"nMoreExtreme":21823,"size":12,"leadingEdge":["FCER1G","FGR"]} {"pathway":"GO_NUCLEOTIDE_SUGAR_TRANSMEMBRANE_TRANSPORT","pval":0.36702,"padj":0.89036,"ES":0.91389,"NES":1.16302,"nMoreExtreme":21602,"size":14,"leadingEdge":["SLC35C2","SLC35E4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY","pval":0.26951,"padj":0.83695,"ES":0.81936,"NES":1.16287,"nMoreExtreme":17723,"size":32,"leadingEdge":["CALCOCO2","PLEK","TNF","UVRAG","ACTN2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION","pval":0.22435,"padj":0.8097,"ES":0.75225,"NES":1.16265,"nMoreExtreme":16095,"size":57,"leadingEdge":["KLF4","MIR503","DUSP10","TGFB1","ADGRB1","MIR212","SLIT2","KRIT1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_DIFFERENTIATION","pval":0.37085,"padj":0.89036,"ES":0.90995,"NES":1.1626,"nMoreExtreme":22036,"size":15,"leadingEdge":["PDGFB","NFATC1","EREG","PRDM6"]} {"pathway":"GO_DE_NOVO_NAD_BIOSYNTHETIC_PROCESS","pval":0.49701,"padj":0.91907,"ES":0.91017,"NES":1.16256,"nMoreExtreme":27774,"size":9,"leadingEdge":["IDO1","IDO2","KYNU","KMO"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS","pval":0.49775,"padj":0.91907,"ES":0.91004,"NES":1.1624,"nMoreExtreme":27815,"size":9,"leadingEdge":["UCP2","PIM3","MAP4K4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_EPIDERMAL_GROWTH_FACTOR_ACTIVATED_RECEPTOR_ACTIVITY","pval":0.49859,"padj":0.91907,"ES":0.90993,"NES":1.16226,"nMoreExtreme":27862,"size":9,"leadingEdge":["NCF1","EREG"]} {"pathway":"GO_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY","pval":0.20906,"padj":0.79637,"ES":0.72599,"NES":1.16218,"nMoreExtreme":15728,"size":76,"leadingEdge":["LRRK2","GCH1","NOD2","AGT","EDN1","SLAMF8","TNF","CYP27B1","MIR212","RFK","S100A1"]} {"pathway":"GO_COFACTOR_CATABOLIC_PROCESS","pval":0.26196,"padj":0.83196,"ES":0.80689,"NES":1.16217,"nMoreExtreme":17459,"size":35,"leadingEdge":["CBR3","GGT5","CHAC1","PRDX1","ACAT1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY","pval":0.44412,"padj":0.90355,"ES":0.91537,"NES":1.1621,"nMoreExtreme":25068,"size":10,"leadingEdge":["STAC3","S100A1","EHD3"]} {"pathway":"GO_LATERAL_VENTRICLE_DEVELOPMENT","pval":0.38708,"padj":0.89277,"ES":0.91756,"NES":1.16192,"nMoreExtreme":22327,"size":12,"leadingEdge":["PAX5","DNAH5"]} {"pathway":"GO_DENDRITIC_TRANSPORT","pval":0.57242,"padj":0.94008,"ES":0.90021,"NES":1.16192,"nMoreExtreme":31540,"size":8,"leadingEdge":["KIF17","WASF1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION","pval":0.03574,"padj":0.48389,"ES":0.63609,"NES":1.16188,"nMoreExtreme":3541,"size":827,"leadingEdge":["TIFA","APOL3","UBD","CD40","CD74","P2RX7","LRRK2","NOD2","CCL13","HGF","TNFSF10","SECTM1","BANK1","JAK2","AGT","RIPK2","CCL7","ICAM1","BCL2L11","CLEC6A","CCL15","TGM2","CD80","TRIM22","CCL8","SCIMP","S100A13","RASGRF1","ZC3H12A","P2RX4","RAPGEF2","CARD16","NPR1","EDN1","SLAMF1","NCF1","NRK","PMAIP1","IL1RN","GADD45B","DDX60","GLIPR2","CCL18","LITAF","CCL5","LYN","PYHIN1","IFIT5","TLR7","TICAM2","CSF1","GAREM1","BIRC3","MYD88","CASP10","NRG4","IL6","TLR3","FGF10","TXN","GADD45G","SEMA7A","NOTCH2","TNF","FLT1","RBCK1","CD86","GPR18","RASGRP1","F2RL2","PIK3AP1","CCL1","FGD2","PTPRC","CHI3L1","CCL4","AUTS2","FPR2","F3","CCL2","GUCA1A","P2RY12","PTPN2","DHX58","PAK1","NRG2","SRC","TGFB1","ICOS","ROBO1","CCL19","CGAS","AKAP12","PDGFRA","IKBKE","RRAGC","DUSP5","GUCY1A1","PTPN1","MCL1","SH3RF1","LPAR1","PLEKHF1","GAS6","CCL3","CX3CL1","TRIM25","CFLAR","TCIM","SLC44A2","RRAGD","GATA3","BIRC7","CASP1","NKX3-1","LIN28A","SEMA4D"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PHOSPHOLIPASE_ACTIVITY","pval":0.24387,"padj":0.82387,"ES":0.77871,"NES":1.16183,"nMoreExtreme":16872,"size":44,"leadingEdge":["ITK","AGT","CCL5","FLT1","PTAFR","P2RY12","PDGFRA","LPAR1","EDNRA"]} {"pathway":"GO_PEPTIDYL_AMINO_ACID_MODIFICATION","pval":0.02096,"padj":0.36542,"ES":0.63477,"NES":1.16166,"nMoreExtreme":2087,"size":1052,"leadingEdge":["IL31RA","CD40","CD74","SOCS1","LRRK2","ITK","IL15","HGF","ATP13A2","ASPHD2","BANK1","EGR2","LMTK2","PADI2","JAK2","AGT","RIPK2","CAMK2D","SPTBN4","ICAM1","MUC1","TGM2","JADE2","ART3","TNFSF18","CD80","JAK3","STAP1","IL12RB2","ENPP2","IFIH1","NCF1","MVP","STAP2","BAZ1A","ZDHHC19","CCL5","LYN","IL12A","PARP14","VRK2","TNFRSF14","PARP9","IL7","PRKX","IRF4","IL6","FGF10","TXN","AURKC","TNF","FLT1","ZDHHC18","NCOA1","ZDHHC11B","PTPRC","CHI3L1","AUTS2","SOCS3","STAT3","PTPN2","PAK1","SRC","TGFB1","PDGFRA","IKBKE","PTPN1","PTGS2","GAS6","EPHA10","GATA3","SRCIN1","MIR212","SEMA4D","SPINK1"]} {"pathway":"GO_SEMICIRCULAR_CANAL_DEVELOPMENT","pval":0.5022,"padj":0.91978,"ES":0.90942,"NES":1.16161,"nMoreExtreme":28064,"size":9,"leadingEdge":["NR4A3","FGF10","TBX1"]} {"pathway":"GO_GROWTH_INVOLVED_IN_SYMBIOTIC_INTERACTION","pval":0.44687,"padj":0.90517,"ES":0.91498,"NES":1.1616,"nMoreExtreme":25223,"size":10,"leadingEdge":["LTA","TNF","IRF8"]} {"pathway":"GO_NEUROTRANSMITTER_REUPTAKE","pval":0.38275,"padj":0.89036,"ES":0.90419,"NES":1.16157,"nMoreExtreme":22927,"size":16,"leadingEdge":["KCNJ10","SLC18A1","GPM6B","DRD4"]} {"pathway":"GO_MUSCLE_CELL_FATE_COMMITMENT","pval":0.50276,"padj":0.91978,"ES":0.90937,"NES":1.16154,"nMoreExtreme":28095,"size":9,"leadingEdge":["FGF10","TBX1","MEF2C"]} {"pathway":"GO_DIVALENT_INORGANIC_CATION_HOMEOSTASIS","pval":0.10345,"padj":0.67471,"ES":0.6474,"NES":1.16136,"nMoreExtreme":9732,"size":364,"leadingEdge":["CD40","P2RX7","SNX10","CXCL11","CD38","CXCL10","CCL13","ATP13A2","CXCL9","JAK2","AGT","CCL7","MCOLN2","CAMK2D","CCL15","TGM2","PML","FAM20A","SRI","CCL8","CCRL2","P2RX4","EDN1","ANK2","MT2A","PTGER4","CCL5","LYN","MT1M","JPH4","PTGER2","SLC8A1","GPR18","F2RL2","MT1E","CCR5","CCL1","CXCL12","CYP27B1","PTPRC","FPR2","ACKR4","TMTC2","TGFB1","CCL19","CCR6","MT1H","PDGFRA","C19orf12","GRINA","PKHD1","LPAR1","CCL3","CX3CL1","MT1G","HERPUD1","PLCB1","CLIC2","SLC8A2","SMAD3"]} {"pathway":"GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_DOPAMINERGIC","pval":0.44822,"padj":0.90517,"ES":0.91476,"NES":1.16131,"nMoreExtreme":25299,"size":10,"leadingEdge":["PTGS2","FLOT1","DRD4"]} {"pathway":"GO_ANTIBACTERIAL_HUMORAL_RESPONSE","pval":0.59971,"padj":0.94564,"ES":0.8878,"NES":1.16131,"nMoreExtreme":32597,"size":7,"leadingEdge":["HLA-E","SLPI"]} {"pathway":"GO_REGULATION_OF_SHORT_TERM_NEURONAL_SYNAPTIC_PLASTICITY","pval":0.39155,"padj":0.89503,"ES":0.91688,"NES":1.16107,"nMoreExtreme":22585,"size":12,"leadingEdge":["SLC8A2","SHISA7","SYNGR1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY","pval":0.18685,"padj":0.78157,"ES":0.696,"NES":1.16105,"nMoreExtreme":15004,"size":114,"leadingEdge":["SPTBN4","PRRT2","MEFV","SCIN","TMSB10","PTGER4","TRIM9","SRC","MAP2","SPTA1","SLIT2"]} {"pathway":"GO_ACTIN_FILAMENT_NETWORK_FORMATION","pval":0.57692,"padj":0.94161,"ES":0.89943,"NES":1.1609,"nMoreExtreme":31788,"size":8,"leadingEdge":["COBL","LCP1","ACTN1"]} {"pathway":"GO_KERATAN_SULFATE_BIOSYNTHETIC_PROCESS","pval":0.32702,"padj":0.87108,"ES":0.8671,"NES":1.16088,"nMoreExtreme":20461,"size":22,"leadingEdge":["B4GALT5","CHST2","ST3GAL1"]} {"pathway":"GO_NUCLEAR_EXPORT","pval":0.15173,"padj":0.75292,"ES":0.66912,"NES":1.16085,"nMoreExtreme":13135,"size":189,"leadingEdge":["EGR2","IFI27","TXN","TGFB1","GAS6","XPO6"]} {"pathway":"GO_XENOBIOTIC_CATABOLIC_PROCESS","pval":0.45117,"padj":0.90517,"ES":0.91433,"NES":1.16077,"nMoreExtreme":25466,"size":10,"leadingEdge":["ACSL1","CYP1A1","ACAA1"]} {"pathway":"GO_MORPHOGENESIS_OF_A_POLARIZED_EPITHELIUM","pval":0.17907,"padj":0.77529,"ES":0.68837,"NES":1.16064,"nMoreExtreme":14654,"size":129,"leadingEdge":["PSME2","PSMB9","PSME1","PSMB10","PSMB8","PSMA4","PSMA2","PSMA5"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SIGNALING","pval":0.00812,"padj":0.23818,"ES":0.63342,"NES":1.16063,"nMoreExtreme":810,"size":1481,"leadingEdge":["TIFA","APOL3","IL31RA","UBD","PSME2","CD40","CD74","P2RX7","SOCS1","LRRK2","PSMB9","CD38","IL15","NOD2","CCL13","HGF","NLRC5","TNFSF10","PSME1","SECTM1","BANK1","DKK2","ATF3","HCAR2","JAK2","PSMB10","AGT","RIPK2","CCL7","FAS","PSMB8","ICAM1","BCL2L11","CLEC6A","CCL15","ZBP1","TGM2","TNFSF18","CD80","TRIM22","PML","SRI","CCL8","C3","CD300LF","SCIMP","S100A13","RASGRF1","ZC3H12A","CYLD","P2RX4","RAPGEF2","CASP4","STAP1","IRF7","CARD16","NPR1","RSAD2","EDN1","SLAMF1","NCF1","NRK","FAM107A","PMAIP1","IL1RN","GADD45B","DDX60","STAP2","GLIPR2","CCL18","LITAF","CCL5","LYN","IL12A","PYHIN1","DTNBP1","IFIT5","GLUL","PARP14","TLR7","TICAM2","CSF1","PARP9","IL7","AMER1","GAREM1","TNFAIP3","RNF207","BIRC3","MYD88","CASP10","NRG4","IL6","TLR3","FGF10","TXN","GADD45G","SEMA7A","NOTCH2","TNF","PSMA4","FLT1","PSMA2","RBCK1","CD226","CD86","GPR18","RASGRP1","F2RL2","PIK3AP1","CCL1","FGD2","ASCL1","CYP27B1","PTPRC","CHI3L1","CCL4","NR1H3","AUTS2","FPR2","F3","SOCS3","CCL2","SH2B2","KMO","STAT3","GUCA1A","P2RY12","PTPN2","DHX58","PAK1","NRG2","SRC","TGFB1","ICOS","ROBO1","CCL19","CGAS","WDFY1","AKAP12","PSMA5","PDGFRA","CTSC","IKBKE","RRAGC","DUSP5","GUCY1A1","CDKN1C","PTPN1","TREML4","MCL1","SH3RF1","LPAR1","PLEKHF1","CREBRF","PTGS2","ADAMTS20","GAS6","CCL3","CX3CL1","ACPP","TRIM25","CFLAR","RGS9","TCIM","ESM1","SLC44A2","RRAGD","GATA3","BIRC7","CASP1","NKX3-1","LIN28A","MIR212","SEMA4D","BBC3","PLCB1","SLC8A2","NADK","PDGFB","SMAD3","STX3","GAS8","ILDR1","BAK1","PRR5L","MAP3K8","NFAM1","NGF","LILRA5","SHISA7","PAG1","HIC1","FLOT1","ARC","RAPSN","SLC35C2","TLR4","MAPK8IP2","CCR1","BLNK","IFNL1"]} {"pathway":"GO_REGULATION_OF_HEPATOCYTE_PROLIFERATION","pval":0.41651,"padj":0.89503,"ES":0.91651,"NES":1.16059,"nMoreExtreme":23782,"size":11,"leadingEdge":["CEACAM1","TNFAIP3","HPN","CFLAR","PTN"]} {"pathway":"GO_RESPONSE_TO_LAMINAR_FLUID_SHEAR_STRESS","pval":0.37988,"padj":0.89036,"ES":0.91198,"NES":1.16059,"nMoreExtreme":22359,"size":14,"leadingEdge":["KLF4","TGFB1","NFE2L2","ASS1"]} {"pathway":"GO_COMMON_PARTNER_SMAD_PROTEIN_PHOSPHORYLATION","pval":0.60011,"padj":0.94564,"ES":0.86793,"NES":1.16057,"nMoreExtreme":32207,"size":6,"leadingEdge":["PML","TGFB1","SPTBN1"]} {"pathway":"GO_GLUTAMINE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS","pval":0.38046,"padj":0.89036,"ES":0.91193,"NES":1.16052,"nMoreExtreme":22393,"size":14,"leadingEdge":["GLUL","GLS","ASS1","CPS1"]} {"pathway":"GO_VACUOLAR_TRANSPORT","pval":0.18107,"padj":0.77555,"ES":0.68895,"NES":1.16004,"nMoreExtreme":14776,"size":127,"leadingEdge":["LRRK2","DTX3L","IGF2R","CHMP4C","SNX16","SORT1","NCOA4","C9orf72","GCC2","NPC1"]} {"pathway":"GO_AGING","pval":0.13422,"padj":0.72971,"ES":0.65825,"NES":1.16004,"nMoreExtreme":12056,"size":248,"leadingEdge":["LRRK2","IL15","SERPING1","AGT","BCL2A1","VCAM1","CYP1A1","ICAM1","PML","EDN1","COMP","HLA-G","POLB","BCL6","LITAF","SOD2","KYNU","NFKB2","KMO","STAT3","GCLC","TGFB1","CGAS","CDKN1A","UCP2","NAMPT","CTSC","CDKN1C","PTGS2","CX3CL1","NFE2L2"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_MANGANESE_ION","pval":0.45633,"padj":0.90517,"ES":0.91365,"NES":1.1599,"nMoreExtreme":25757,"size":10,"leadingEdge":["LRRK2","ATP13A2","HSPA5"]} {"pathway":"GO_SULFUR_AMINO_ACID_METABOLIC_PROCESS","pval":0.38443,"padj":0.89083,"ES":0.91136,"NES":1.1598,"nMoreExtreme":22627,"size":14,"leadingEdge":["MTHFR","CBSL","CPS1"]} {"pathway":"GO_RESPONSE_TO_STEROL_DEPLETION","pval":0.45734,"padj":0.90517,"ES":0.91352,"NES":1.15975,"nMoreExtreme":25814,"size":10,"leadingEdge":["LYN","ERLIN1","INSIG2","ARHGEF10L"]} {"pathway":"GO_NUCLEOTIDE_BINDING_OLIGOMERIZATION_DOMAIN_CONTAINING_2_SIGNALING_PATHWAY","pval":0.39986,"padj":0.89503,"ES":0.91576,"NES":1.15965,"nMoreExtreme":23064,"size":12,"leadingEdge":["NOD2","RIPK2","TNFAIP3","NFKBIA","TLR4"]} {"pathway":"GO_ENDOSOMAL_TRANSPORT","pval":0.14829,"padj":0.7508,"ES":0.66439,"NES":1.15948,"nMoreExtreme":13006,"size":208,"leadingEdge":["LRRK2","LMTK2","RHOBTB3","CHMP4C","DENND1B","AP5B1","SORT1","ACTN2","SNX8","DENND5A","RAB11FIP4","GCC2","MYO5B"]} {"pathway":"GO_REGULATION_OF_B_CELL_MEDIATED_IMMUNITY","pval":0.24624,"padj":0.82387,"ES":0.77435,"NES":1.15934,"nMoreExtreme":17095,"size":45,"leadingEdge":["CD40","TBX21","HLA-E","C3","BCL6","LTA","PARP3","TNF","CD226","PTPRC","TGFB1"]} {"pathway":"GO_MICROTUBULE_ANCHORING_AT_CENTROSOME","pval":0.46126,"padj":0.90517,"ES":0.91296,"NES":1.15903,"nMoreExtreme":26035,"size":10,"leadingEdge":["CCDC68","PCM1"]} {"pathway":"GO_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION","pval":0.19158,"padj":0.79001,"ES":0.69644,"NES":1.15886,"nMoreExtreme":15311,"size":111,"leadingEdge":["HGF","RIPK2","SPTBN4","IL6","TXN","TNF","PAK1","TGFB1","PTGS2","GAS6","MIR212","BAK1","FNIP2"]} {"pathway":"GO_CARNITINE_SHUTTLE","pval":0.46297,"padj":0.90517,"ES":0.91279,"NES":1.15882,"nMoreExtreme":26132,"size":10,"leadingEdge":["CPT1A","ACACB"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_COPPER_ION","pval":0.32175,"padj":0.86901,"ES":0.85987,"NES":1.15876,"nMoreExtreme":20243,"size":23,"leadingEdge":["CYP1A1","MT2A","MT1M","MT1E","MT1H","MT1G","NFE2L2","AOC1"]} {"pathway":"GO_REGULATION_OF_MEMBRANE_DEPOLARIZATION","pval":0.2638,"padj":0.8333,"ES":0.80087,"NES":1.15867,"nMoreExtreme":17671,"size":36,"leadingEdge":["P2RX7","LRRK2","CAMK2D","GCLC","SRC","IFI6"]} {"pathway":"GO_CARDIAC_RIGHT_VENTRICLE_MORPHOGENESIS","pval":0.39572,"padj":0.89503,"ES":0.90185,"NES":1.15858,"nMoreExtreme":23704,"size":16,"leadingEdge":["GATA3","SMARCD3","SEMA3C"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MHC_CLASS_I_BIOSYNTHETIC_PROCESS","pval":0.5827,"padj":0.94167,"ES":0.84217,"NES":1.15847,"nMoreExtreme":30832,"size":5,"leadingEdge":["CIITA","NLRC5","IFNL1"]} {"pathway":"GO_LIVER_MORPHOGENESIS","pval":0.39187,"padj":0.89503,"ES":0.90669,"NES":1.15843,"nMoreExtreme":23285,"size":15,"leadingEdge":["CEACAM1","TNFAIP3","HPN","CFLAR","PROX1","PTN"]} {"pathway":"GO_POSITIVE_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY","pval":0.24738,"padj":0.82387,"ES":0.77372,"NES":1.1584,"nMoreExtreme":17174,"size":45,"leadingEdge":["GCH1","NOD2","AGT","EDN1","TNF","CYP27B1","RFK","S100A1"]} {"pathway":"GO_REGULATION_OF_URINE_VOLUME","pval":0.39217,"padj":0.89503,"ES":0.90665,"NES":1.15838,"nMoreExtreme":23303,"size":15,"leadingEdge":["NPR1","EDN1","HAS2","ADORA2A"]} {"pathway":"GO_REGULATION_OF_CILIUM_ASSEMBLY","pval":0.24876,"padj":0.82387,"ES":0.77639,"NES":1.15837,"nMoreExtreme":17210,"size":44,"leadingEdge":["CYLD","CDKL1","ATG3","HAP1","MARK4"]} {"pathway":"GO_REGULATION_OF_ION_TRANSPORT","pval":0.08953,"padj":0.65986,"ES":0.64101,"NES":1.15828,"nMoreExtreme":8585,"size":456,"leadingEdge":["ATP1B2","P2RX7","CXCL11","PDE4B","CXCL10","SLC31A2","CXCL9","KCNJ10","AGT","KCNJ2","CAMK2D","SPTBN4","ICAM1","KCNJ15","PML","SRI","B2M","RASGRF1","ABCB1","CTSS","P2RX4","TMEM109","EDN1","LILRA2","ANK2","CLIC5","DYSF","CCL5","LYN","DTNBP1","KCNE5","ANXA3","RNF207","STAC3","JPH4","SLC8A1","SCN9A","CXCL12","GEM","PTAFR","CCL4","LILRB1","KCNE1","PSEN2","CCL2","KMO","CACNA1I","P2RY12","TGFB1","KCNMA1","SYT5","SNX16","HVCN1","ACTN2","GPM6B","PTGS2","CCL3","CX3CL1","PRELID1","RGS9","MIR212","SPINK1","CLIC2","PDGFB","SYT17","GLRX","KCNE1B","BAK1","STOM","SIK1","LILRA5","SHISA7","S100A1","ARC","MAPK8IP2","CCR1","KCNMB1"]} {"pathway":"GO_CYTOKINE_METABOLIC_PROCESS","pval":0.20321,"padj":0.79603,"ES":0.70708,"NES":1.15769,"nMoreExtreme":15815,"size":94,"leadingEdge":["IRF1","LAG3","NMI","TLR8","IL27","KLF4","CD80","IRF7","TLR7","IRF4","IL6","TLR3","LTB","TNF","EBI3","CD86","PTPRC","PTAFR","LILRB1","STAT3","GATA3","ZFP36","IL1A"]} {"pathway":"GO_MACROPHAGE_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE","pval":0.43338,"padj":0.90066,"ES":0.91413,"NES":1.15758,"nMoreExtreme":24745,"size":11,"leadingEdge":["SUCNR1","SBNO2","DYSF","IL33","TICAM1"]} {"pathway":"GO_MYOBLAST_MIGRATION","pval":0.43361,"padj":0.90066,"ES":0.91408,"NES":1.15751,"nMoreExtreme":24758,"size":11,"leadingEdge":["PLEKHO1","SIX1","ROCK1"]} {"pathway":"GO_NEGATIVE_REGULATION_BY_HOST_OF_VIRAL_PROCESS","pval":0.58632,"padj":0.94167,"ES":0.89677,"NES":1.15747,"nMoreExtreme":32306,"size":8,"leadingEdge":["CCL8","ZC3H12A","CCNK"]} {"pathway":"GO_INTERLEUKIN_18_MEDIATED_SIGNALING_PATHWAY","pval":0.58632,"padj":0.94167,"ES":0.89669,"NES":1.15737,"nMoreExtreme":32306,"size":8,"leadingEdge":["IL18BP","TICAM2","PDGFB","IL18RAP"]} {"pathway":"GO_INTERLEUKIN_12_SECRETION","pval":0.52609,"padj":0.92669,"ES":0.90594,"NES":1.15716,"nMoreExtreme":29399,"size":9,"leadingEdge":["TLR8","LILRB1","CCL19","LILRA5","MAPK11"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MITOCHONDRION_ORGANIZATION","pval":0.2491,"padj":0.82387,"ES":0.77287,"NES":1.15712,"nMoreExtreme":17293,"size":45,"leadingEdge":["LRRK2","HGF","PRELID1","SLC25A5"]} {"pathway":"GO_REGULATION_OF_EXCRETION","pval":0.39887,"padj":0.89503,"ES":0.9092,"NES":1.15704,"nMoreExtreme":23477,"size":14,"leadingEdge":["AGT","NPR1","EDN1","ADORA2A"]} {"pathway":"GO_GOLGI_VESICLE_TRANSPORT","pval":0.11828,"padj":0.70259,"ES":0.64725,"NES":1.15666,"nMoreExtreme":11010,"size":331,"leadingEdge":["VAMP5","LRRK2","OPTN","TAPBP","SPTBN4","IGF2R","ANK2","DOP1A","TICAM2","CTSZ","UVRAG","CTSC","SORT1","AMN","GAS6","AP1AR","SNX8","NAPA","LMF1","SPTA1","STX17"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_B_CELL_MEDIATED_IMMUNITY","pval":0.58661,"padj":0.94167,"ES":0.89611,"NES":1.15662,"nMoreExtreme":32322,"size":8,"leadingEdge":["BCL6","PARP3","FCGR2B"]} {"pathway":"GO_MITOCHONDRION_DISTRIBUTION","pval":0.4005,"padj":0.89503,"ES":0.90527,"NES":1.15661,"nMoreExtreme":23798,"size":15,"leadingEdge":["LRRK2","HAP1"]} {"pathway":"GO_REGULATION_OF_CATABOLIC_PROCESS","pval":0.03734,"padj":0.49711,"ES":0.63293,"NES":1.15656,"nMoreExtreme":3704,"size":873,"leadingEdge":["PSME2","P2RX7","CALCOCO2","LRRK2","PSMB9","LAMP3","HGF","ATP13A2","PSME1","OPTN","HCAR2","PSMB10","NUB1","RIPK2","PSMB8","XRN1","BCL2L11","SAMD4A","TRIM22","PML","RNF19B","MEFV","ZC3H12A","DRAM1","RALB","GTPBP1","DTX3L","DYSF","PYHIN1","RUFY4","TMEM150A","AMER1","TNFAIP3","EDEM1","RNF144B","MYD88","TNF","RMC1","PSMA4","PSMA2","AZIN2","MOV10","STAT3","TRIM71","GCLC","UVRAG","PSMA5","ATP6V1A","NAMPT","TRIM21","CTSC","RRAGC","PTPN1","MCL1","ADGRB1","PLEKHF1","DEPP1","RRAGD","NFE2L2","IL33","HERPUD1","DAPK2","SMAD3","ZFP36","PRR5L","NUPR1","RNF19A","ESRRB","C9orf72","AGAP2","CPT1A","NPC1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ERAD_PATHWAY","pval":0.40175,"padj":0.89503,"ES":0.90501,"NES":1.15628,"nMoreExtreme":23872,"size":15,"leadingEdge":["EDEM1","NFE2L2","HERPUD1","EDEM2","USP13"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_ABIOTIC_STIMULUS","pval":0.13446,"padj":0.72971,"ES":0.65341,"NES":1.1562,"nMoreExtreme":12201,"size":268,"leadingEdge":["IRF1","CD40","AGT","TLR8","FAS","KCNJ2","CARD16","TMEM109","DYSF","PTGER4","RELB","TLR7","TANK","MYD88","TLR3","ASCL1","PTAFR","CASP5","GUCA1A","GCLC","TGFB1","CDKN1A","NAMPT","HVCN1","LIG4","PTGS2","GATA3","CASP1","RCSD1","BAK1"]} {"pathway":"GO_ENDOPLASMIC_RETICULUM_MANNOSE_TRIMMING","pval":0.40229,"padj":0.89503,"ES":0.9049,"NES":1.15613,"nMoreExtreme":23904,"size":15,"leadingEdge":["EDEM1","EDEM2","SEL1L"]} {"pathway":"GO_MICROTUBULE_ANCHORING_AT_MICROTUBULE_ORGANIZING_CENTER","pval":0.41915,"padj":0.89569,"ES":0.91295,"NES":1.15609,"nMoreExtreme":24177,"size":12,"leadingEdge":["CCDC68","PCM1"]} {"pathway":"GO_ENTRY_OF_BACTERIUM_INTO_HOST_CELL","pval":0.40407,"padj":0.89503,"ES":0.90844,"NES":1.15608,"nMoreExtreme":23783,"size":14,"leadingEdge":["SRC","CXCL8","MET","FUCA2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INTERLEUKIN_13_PRODUCTION","pval":0.41948,"padj":0.8957,"ES":0.91293,"NES":1.15607,"nMoreExtreme":24196,"size":12,"leadingEdge":["HLA-E","IRF4","GATA3","IL33"]} {"pathway":"GO_CARBOHYDRATE_DERIVATIVE_CATABOLIC_PROCESS","pval":0.17337,"padj":0.77508,"ES":0.67671,"NES":1.15594,"nMoreExtreme":14542,"size":152,"leadingEdge":["FBXO6","PDE4B","DPYS","TYMP","APOBEC3D","ENPP4","APOBEC3A","APOBEC3G","SDC3","EDEM1","APOBEC3F","TGFB1","ADA2","GM2A","GPD2","GNS"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SIGNALING_RECEPTOR_ACTIVITY","pval":0.29397,"padj":0.854,"ES":0.83179,"NES":1.15593,"nMoreExtreme":18989,"size":28,"leadingEdge":["IL18BP","DKK2","LY6E","CLEC12B"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS","pval":0.03808,"padj":0.50182,"ES":0.63258,"NES":1.15592,"nMoreExtreme":3777,"size":873,"leadingEdge":["GBP1","C4A","P2RX7","SOCS1","LRRK2","C4B","SERPING1","LAG3","LAMP3","CEACAM1","HGF","ATP13A2","BANK1","ATF3","LMTK2","NMI","AGT","PZP","XRN1","KLF4","SAMD4A","PML","C3","ZC3H12A","PARP10","CYLD","CARD17","CARD16","BTN2A2","EDN1","DTX3L","MIR503","MVP","GADD45B","DYSF","PPM1E","LYN","DTNBP1","CHAC1","PARP14","TNFAIP3","BIRC3","CTSZ","IL6","TNF","SERPINB9","SPOPL","DUSP10","MOV10","PTPRC","LILRB1","SOCS3","STAT3","PTPN2","TRIM71","GCLC","SRC","TGFB1","A2M","CDKN1A","TRIM21","ADAR","DUSP5","CDKN1C","UBE2Z","PTPN1","IFI6","ADGRB1","ISG15","SH3RF1","PTGS2","ELFN1","GAS6","CFLAR","BIRC7","SRCIN1","LIN28A","MIR212","SEMA4D","SERPINB1","SPINK1","HERPUD1","IL1R2","HMSD","ZFP36","SLIT2","BAK1","PRR5L","MYOZ1","PAX5","NGF","TNFAIP8","C9orf72","PPP1R16B","HEG1","TLR4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_HAIR_CYCLE","pval":0.48012,"padj":0.91595,"ES":0.91043,"NES":1.15582,"nMoreExtreme":27100,"size":10,"leadingEdge":["TNF","FST","GAL"]} {"pathway":"GO_PROSTANOID_BIOSYNTHETIC_PROCESS","pval":0.36567,"padj":0.89036,"ES":0.88133,"NES":1.15567,"nMoreExtreme":22458,"size":19,"leadingEdge":["CD74","EDN1","CBR1","PTGS2"]} {"pathway":"GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY","pval":0.13779,"padj":0.73301,"ES":0.65439,"NES":1.1556,"nMoreExtreme":12442,"size":258,"leadingEdge":["CD74","LRRK2","JAK2","BCL2A1","BCL2L11","MUC1","PML","CYLD","CASP4","TMEM109","PMAIP1","POLB","CHAC1","SOD2","TNF","CUL1","CXCL12","NBN","PTPN2","SRC","CDKN1A","IKBKE","PTPN1","IFI6","GRINA","MCL1","PLEKHF1","PTGS2","NKX3-1","NFE2L2","HERPUD1","DAPK2","BBC3","BAK1","NUPR1","HIC1","FNIP2"]} {"pathway":"GO_GLYCOLYTIC_PROCESS","pval":0.21072,"padj":0.79831,"ES":0.71152,"NES":1.15554,"nMoreExtreme":16192,"size":87,"leadingEdge":["P2RX7","PFKP","STAT3","ESRRB","HDAC4"]} {"pathway":"GO_AMIDE_BIOSYNTHETIC_PROCESS","pval":0.05719,"padj":0.57275,"ES":0.63397,"NES":1.15553,"nMoreExtreme":5631,"size":690,"leadingEdge":["P2RX7","BANK1","ACSL1","XRN1","SAMD4A","ZC3H12A","PPA1","GTPBP1","CNDP2","PIWIL4","MIR503","GGT5","CCL5","CHAC1","B4GALT5","IL6","TNF","SMPD3","MOV10","ACSL5","PTAFR","ST3GAL5","ELOVL7","STAT3","TRIM71","GCLC","ACSS1","NFE2L2","LIN28A","MIR212"]} {"pathway":"GO_REGULATION_OF_APOPTOTIC_PROCESS_INVOLVED_IN_MORPHOGENESIS","pval":0.53477,"padj":0.92816,"ES":0.90465,"NES":1.15551,"nMoreExtreme":29884,"size":9,"leadingEdge":["FOXC1","HNF1B","TNFRSF1B"]} {"pathway":"GO_REGULATION_OF_APOPTOTIC_PROCESS_INVOLVED_IN_DEVELOPMENT","pval":0.53477,"padj":0.92816,"ES":0.90465,"NES":1.15551,"nMoreExtreme":29884,"size":9,"leadingEdge":["FOXC1","HNF1B","TNFRSF1B"]} {"pathway":"GO_REGULATION_OF_ESTABLISHMENT_OF_PLANAR_POLARITY","pval":0.20238,"padj":0.79569,"ES":0.69916,"NES":1.1554,"nMoreExtreme":15995,"size":103,"leadingEdge":["PSME2","PSMB9","PSME1","PSMB10","PSMB8","PSMA4","PSMA2","PSMA5"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ION_TRANSPORT","pval":0.15935,"padj":0.76421,"ES":0.66493,"NES":1.15524,"nMoreExtreme":13833,"size":194,"leadingEdge":["ATP1B2","P2RX7","CXCL11","CXCL10","CXCL9","AGT","KCNJ2","SRI","ABCB1","CTSS","P2RX4","EDN1","LILRA2","ANK2","CCL5","KCNE5","RNF207","STAC3","CXCL12","PTAFR","CCL4","KCNE1","CCL2","KMO","P2RY12","ACTN2","CCL3","CX3CL1","PRELID1","RGS9","PDGFB","GLRX","BAK1","LILRA5","S100A1","ARC","CCR1","KCNMB1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_VASCULAR_SMOOTH_MUSCLE_CELL_DIFFERENTIATION","pval":0.58351,"padj":0.94167,"ES":0.83982,"NES":1.15524,"nMoreExtreme":30875,"size":5,"leadingEdge":["SOD2","CTH"]} {"pathway":"GO_SODIUM_ION_IMPORT_ACROSS_PLASMA_MEMBRANE","pval":0.44644,"padj":0.90517,"ES":0.91228,"NES":1.15523,"nMoreExtreme":25491,"size":11,"leadingEdge":["SLC8A1","SLC9A4","SLC9A7"]} {"pathway":"GO_MONOUBIQUITINATED_PROTEIN_DEUBIQUITINATION","pval":0.53822,"padj":0.92855,"ES":0.90414,"NES":1.15486,"nMoreExtreme":30077,"size":9,"leadingEdge":["USP15","ATXN3"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_CELL_SURFACE","pval":0.23786,"padj":0.82177,"ES":0.75051,"NES":1.15472,"nMoreExtreme":16980,"size":55,"leadingEdge":["ANK2","PTPRU","FGF10","TNF","ACTN2","GPM6B","STX3","FCER1G","HFE"]} {"pathway":"GO_ERAD_PATHWAY","pval":0.2082,"padj":0.79637,"ES":0.70607,"NES":1.15467,"nMoreExtreme":16172,"size":93,"leadingEdge":["FBXO6","EDEM1","TRIM25","ERLIN1","NFE2L2","HERPUD1","EDEM2"]} {"pathway":"GO_DNA_TEMPLATED_TRANSCRIPTION_TERMINATION","pval":0.22198,"padj":0.80586,"ES":0.72434,"NES":1.15458,"nMoreExtreme":16602,"size":73,"leadingEdge":["TAF1A","MNAT1"]} {"pathway":"GO_RESPONSE_TO_INTERLEUKIN_18","pval":0.45084,"padj":0.90517,"ES":0.91173,"NES":1.15454,"nMoreExtreme":25742,"size":11,"leadingEdge":["IL18BP","RIPK2","TICAM2","PDGFB","IL18RAP"]} {"pathway":"GO_EMBRYONIC_VISCEROCRANIUM_MORPHOGENESIS","pval":0.48733,"padj":0.91689,"ES":0.90942,"NES":1.15454,"nMoreExtreme":27507,"size":10,"leadingEdge":["CHST11","AUTS2","TBX1","NDST1"]} {"pathway":"GO_CARDIAC_MUSCLE_CELL_MYOBLAST_DIFFERENTIATION","pval":0.54008,"padj":0.92877,"ES":0.90386,"NES":1.1545,"nMoreExtreme":30181,"size":9,"leadingEdge":["PRICKLE1","REST"]} {"pathway":"GO_COENZYME_METABOLIC_PROCESS","pval":0.15334,"padj":0.75344,"ES":0.65953,"NES":1.15421,"nMoreExtreme":13537,"size":218,"leadingEdge":["IDO1","GCH1","CD38","IDO2","ACSL1","CBR3","PARP10","ACOT4","MTHFD2","DGAT2","PARP9","KYNU","ACSL5","ELOVL7","KMO","ACSS1","NAMPT","PTGS2","ACSM5","NADK","RFK"]} {"pathway":"GO_HOMOCYSTEINE_METABOLIC_PROCESS","pval":0.45338,"padj":0.90517,"ES":0.91138,"NES":1.15409,"nMoreExtreme":25887,"size":11,"leadingEdge":["MTHFR","CBSL","CPS1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT","pval":0.36747,"padj":0.89036,"ES":0.88008,"NES":1.15402,"nMoreExtreme":22568,"size":19,"leadingEdge":["KCNE5","KCNE1","ACTN2","MIR212","KCNE1B","NEDD4L"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION","pval":0.60315,"padj":0.94684,"ES":0.88219,"NES":1.15397,"nMoreExtreme":32784,"size":7,"leadingEdge":["SLC8A1","SMAD3","GOT1"]} {"pathway":"GO_MONOCYTE_CHEMOTAXIS","pval":0.24765,"padj":0.82387,"ES":0.76364,"NES":1.1539,"nMoreExtreme":17338,"size":48,"leadingEdge":["CXCL10","CCL13","CCL7","CCL15","CCL8","SLAMF8","CCL18","CCL5","LYN","IL6","FLT1","CCL1","CXCL12","CCL4","FPR2","CCL2","CCL19","CCL3","CX3CL1","PDGFB","SLIT2","CCR1","CCL3L1"]} {"pathway":"GO_REGULATION_OF_CELLULAR_RESPONSE_TO_STRESS","pval":0.06434,"padj":0.59712,"ES":0.6336,"NES":1.15378,"nMoreExtreme":6316,"size":649,"leadingEdge":["CD74","LRRK2","GCH1","NOD2","HGF","KREMEN1","RIPK2","FAS","CAMK2D","RMI2","KLF4","SCARF1","BCL2L11","MUC1","PML","ZC3H12A","CYLD","EDN1","SLAMF1","NCF1","DTX3L","NRK","PMAIP1","IL1RN","GADD45B","HLA-G","BCL6","LYN","PYHIN1","DTNBP1","NR4A3","PARP3","PARP9","SOD2","EDEM1","TLR3","FGF10","TXN","GADD45G","TNF","DUSP10","RASGRP1","FGD2","CXCL12","PTPN2","PAK1","CCL19","CGAS","PRDX1","NAMPT","HELB","PTPN1","RGMA","GRINA","MCL1","SH3RF1","PTGS2","BIRC7","NKX3-1","NFE2L2","HERPUD1","PLCB1"]} {"pathway":"GO_RESPONSE_TO_PAIN","pval":0.41573,"padj":0.89503,"ES":0.90659,"NES":1.15373,"nMoreExtreme":24469,"size":14,"leadingEdge":["GCH1","P2RX4","SCN9A"]} {"pathway":"GO_POSITIVE_REGULATION_OF_HEART_CONTRACTION","pval":0.35545,"padj":0.88844,"ES":0.87388,"NES":1.15371,"nMoreExtreme":21971,"size":20,"leadingEdge":["GCH1","EDN1","RNF207","KCNQ1"]} {"pathway":"GO_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION","pval":0.24436,"padj":0.82387,"ES":0.75715,"NES":1.15371,"nMoreExtreme":17262,"size":51,"leadingEdge":["LILRB3","CSF1","TLR3","LILRB4","NOTCH2","TNF","LILRB1","OCSTAMP","CCL3","PPARGC1B","TLR4","CCR1"]} {"pathway":"GO_REGULATORY_T_CELL_DIFFERENTIATION","pval":0.3081,"padj":0.86308,"ES":0.83993,"NES":1.15317,"nMoreExtreme":19712,"size":26,"leadingEdge":["IRF1","SOCS1","CTLA4","BTN2A2","HLA-G","BCL6","LILRB4","DUSP10","RUNX1","TGFB1","IL2RA"]} {"pathway":"GO_EMBRYONIC_CAMERA_TYPE_EYE_FORMATION","pval":0.49472,"padj":0.91907,"ES":0.90829,"NES":1.15311,"nMoreExtreme":27924,"size":10,"leadingEdge":["PROX1","WNT5A"]} {"pathway":"GO_INACTIVATION_OF_MAPK_ACTIVITY","pval":0.32118,"padj":0.86901,"ES":0.85015,"NES":1.15301,"nMoreExtreme":20340,"size":24,"leadingEdge":["DUSP10","DUSP5","DUSP2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS","pval":0.43658,"padj":0.90126,"ES":0.91048,"NES":1.15296,"nMoreExtreme":25182,"size":12,"leadingEdge":["PLEK","CYP27B1","ERLIN1","DKK3"]} {"pathway":"GO_REGULATION_OF_LEUKOCYTE_ADHESION_TO_VASCULAR_ENDOTHELIAL_CELL","pval":0.4172,"padj":0.89503,"ES":0.90238,"NES":1.15291,"nMoreExtreme":24790,"size":15,"leadingEdge":["ICAM1","KLF4","TNF","CXCL12","PTAFR","RHOA"]} {"pathway":"GO_POSITIVE_REGULATION_OF_RUFFLE_ASSEMBLY","pval":0.42013,"padj":0.89612,"ES":0.9098,"NES":1.15287,"nMoreExtreme":24468,"size":13,"leadingEdge":["P2RY12","COBL"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PROTEIN_SUMOYLATION","pval":0.54878,"padj":0.93125,"ES":0.90251,"NES":1.15278,"nMoreExtreme":30667,"size":9,"leadingEdge":["MAGEA2","HMG20B"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PEPTIDE_SECRETION","pval":0.20437,"padj":0.79637,"ES":0.69546,"NES":1.15261,"nMoreExtreme":16234,"size":106,"leadingEdge":["GBP1","CD74","BANK1","TLR8","PML","ZC3H12A","CARD17","CARD16","RSAD2","BTN2A2","PTGER4","TNFAIP3","TNF","NR1H3","LILRB1","UCP2","RHBDF2","GAS6","CX3CL1","SRCIN1","IL33","IL1R2"]} {"pathway":"GO_PITUITARY_GLAND_DEVELOPMENT","pval":0.31574,"padj":0.86617,"ES":0.8446,"NES":1.15257,"nMoreExtreme":20113,"size":25,"leadingEdge":["HESX1","FGF10","TBX19","ALDH1A2","SOX2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS","pval":0.42017,"padj":0.89612,"ES":0.90185,"NES":1.15225,"nMoreExtreme":24967,"size":15,"leadingEdge":["ATF3","PMAIP1","TIMP3"]} {"pathway":"GO_MIDBRAIN_DOPAMINERGIC_NEURON_DIFFERENTIATION","pval":0.4231,"padj":0.89612,"ES":0.90535,"NES":1.15215,"nMoreExtreme":24903,"size":14,"leadingEdge":["NR4A2","WNT1","LRP6"]} {"pathway":"GO_MESENCHYMAL_EPITHELIAL_CELL_SIGNALING","pval":0.60413,"padj":0.94684,"ES":0.88076,"NES":1.1521,"nMoreExtreme":32837,"size":7,"leadingEdge":["HGF","FGF10","TNC"]} {"pathway":"GO_REGULATION_OF_LEUKOCYTE_MIGRATION","pval":0.1788,"padj":0.77529,"ES":0.67327,"NES":1.15208,"nMoreExtreme":15057,"size":155,"leadingEdge":["CD74","CXCL10","PADI2","CCL7","ICAM1","TNFSF18","CCL8","P2RX4","STAP1","EDN1","VEGFC","DYSF","SLAMF8","PTGER4","CCL5","LYN","IL12A","CSF1","TNFRSF14","IL6","TNF","GPR18","CAMK1D","SMPD3","CCL1","CXCL12","PTAFR","CCL4","FPR2","CCL2","P2RY12","TGFB1","CCL19","CCR6","CXCL8","RIPOR2","GAS6","CCL3","IL33","DAPK2","PLCB1"]} {"pathway":"GO_REGULATION_OF_NON_MOTILE_CILIUM_ASSEMBLY","pval":0.50011,"padj":0.91966,"ES":0.90745,"NES":1.15204,"nMoreExtreme":28228,"size":10,"leadingEdge":["HAP1","MAP4"]} {"pathway":"GO_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY","pval":0.26676,"padj":0.83635,"ES":0.78609,"NES":1.15202,"nMoreExtreme":18118,"size":39,"leadingEdge":["ATP1B2","ANK2","KCNE5","RNF207","KCNE1","ACTN2","MIR212","KCNE1B"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NF_KAPPAB_TRANSCRIPTION_FACTOR_ACTIVITY","pval":0.18545,"padj":0.77993,"ES":0.67835,"NES":1.15199,"nMoreExtreme":15383,"size":141,"leadingEdge":["AIM2","CD40","NOD2","RHEBL1","AGT","RIPK2","ICAM1","TNFSF18","TRIM22","CARD16","MYD88","TLR3","NFKB2","TNF","RBCK1","STAT3","TGFB1","CX3CL1","TRIM25","CFLAR","TRAF1","FLOT1","TLR4","IL18RAP"]} {"pathway":"GO_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING","pval":0.42541,"padj":0.89739,"ES":0.90496,"NES":1.15165,"nMoreExtreme":25039,"size":14,"leadingEdge":["ZFP36","BTG2","PABPC1"]} {"pathway":"GO_EMBRYONIC_DIGESTIVE_TRACT_MORPHOGENESIS","pval":0.42696,"padj":0.8986,"ES":0.90473,"NES":1.15136,"nMoreExtreme":25130,"size":14,"leadingEdge":["FGF10","PDGFRA","HLX","HNF1B"]} {"pathway":"GO_POSITIVE_REGULATION_OF_B_CELL_ACTIVATION","pval":0.2326,"padj":0.81508,"ES":0.73271,"NES":1.15133,"nMoreExtreme":17068,"size":65,"leadingEdge":["CD40","CD74","CD38","TBX21","NOD2","TNFSF13B","BCL6","IL7","IL6","PTPRC","TGFB1"]} {"pathway":"GO_SYNAPTIC_VESICLE_EXOCYTOSIS","pval":0.21158,"padj":0.79855,"ES":0.70173,"NES":1.1513,"nMoreExtreme":16508,"size":96,"leadingEdge":["P2RX7","LRRK2","STX11","GRIN3A","ERC2","PRRT2","DTNBP1","CADPS2","TRIM9","SYT5","NAPA","STX3","SYT17"]} {"pathway":"GO_RESPONSE_TO_TEMPERATURE_STIMULUS","pval":0.1633,"padj":0.76896,"ES":0.66071,"NES":1.15115,"nMoreExtreme":14264,"size":202,"leadingEdge":["CXCL10","MYOF","CAMK2D","HSBP1L1","LYN","TFEC","VGF","CXCL12","GCLC","CDKN1A","UCP2","NFKBIA","PTGS2","TCIM","MICB","IL1A"]} {"pathway":"GO_FUCOSYLATION","pval":0.42531,"padj":0.89739,"ES":0.9009,"NES":1.15103,"nMoreExtreme":25272,"size":15,"leadingEdge":["FUT4","SLC35C2","FUT1","FUT8"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MEMBRANE_POTENTIAL","pval":0.50629,"padj":0.92065,"ES":0.90655,"NES":1.1509,"nMoreExtreme":28577,"size":10,"leadingEdge":["PMAIP1","PRELID1","PTN","HEBP2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_POLYMERIZATION","pval":0.20063,"padj":0.79183,"ES":0.68873,"NES":1.15068,"nMoreExtreme":16147,"size":116,"leadingEdge":["ICAM1","SCIN","ACTR3C","PAK1","CDC42EP2","TPPP","AP1AR","MET"]} {"pathway":"GO_MONOVALENT_INORGANIC_CATION_HOMEOSTASIS","pval":0.20481,"padj":0.79637,"ES":0.69191,"NES":1.15064,"nMoreExtreme":16357,"size":110,"leadingEdge":["ATP1B2","LRRK2","KCNJ10","AGT","SLC12A3","KCNJ2","RAB20","NPR1","EDN1","SLAMF8","SLC8A1","SLC12A7","SLC4A10","KCNMA1","ATP6V1A","RAB38","RAB39A"]} {"pathway":"GO_REGULATION_OF_VASCULAR_SMOOTH_MUSCLE_CELL_PROLIFERATION","pval":0.25097,"padj":0.82605,"ES":0.75937,"NES":1.15057,"nMoreExtreme":17609,"size":49,"leadingEdge":["JAK2","AGT","EDN1","MIR503","NR4A3","SOD2","TNF","PAK1","CDKN1A","PDGFB"]} {"pathway":"GO_PROTEIN_HEXAMERIZATION","pval":0.44966,"padj":0.90517,"ES":0.90856,"NES":1.15054,"nMoreExtreme":25937,"size":12,"leadingEdge":["PANX2","SPAST"]} {"pathway":"GO_PROTEIN_FOLDING","pval":0.16707,"padj":0.77278,"ES":0.66225,"NES":1.15035,"nMoreExtreme":14498,"size":193,"leadingEdge":["CD74","B2M","RGS9","PTGES3L","FKBP4"]} {"pathway":"GO_DETECTION_OF_EXTERNAL_BIOTIC_STIMULUS","pval":0.43246,"padj":0.90066,"ES":0.90387,"NES":1.15027,"nMoreExtreme":25454,"size":14,"leadingEdge":["C4B","NOD2","TLR4","TLR1"]} {"pathway":"GO_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION","pval":0.20939,"padj":0.79644,"ES":0.69533,"NES":1.15027,"nMoreExtreme":16582,"size":104,"leadingEdge":["CD40","AMOT","KLF4","P2RX4","VEGFC","MIR503","EGR3","STAT5A","TGFB1","ROBO1","PTGS2","NFE2L2","MIR212","PDGFB","SLIT2"]} {"pathway":"GO_REGULATION_OF_STEROID_METABOLIC_PROCESS","pval":0.2153,"padj":0.80139,"ES":0.70516,"NES":1.15022,"nMoreExtreme":16645,"size":91,"leadingEdge":["AGT","TTC39B","DGAT2","TNF","CYP27B1","ERLIN1","LMF1","INSIG2","PROX1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_JNK_CASCADE","pval":0.28636,"padj":0.84868,"ES":0.81044,"NES":1.15021,"nMoreExtreme":18831,"size":32,"leadingEdge":["CYLD","DUSP10","PAFAH1B1"]} {"pathway":"GO_CELL_DIFFERENTIATION_IN_HINDBRAIN","pval":0.45116,"padj":0.90517,"ES":0.90828,"NES":1.15018,"nMoreExtreme":26023,"size":12,"leadingEdge":["PROX1","RORA"]} {"pathway":"GO_KIDNEY_MESENCHYME_DEVELOPMENT","pval":0.43049,"padj":0.89981,"ES":0.89998,"NES":1.14986,"nMoreExtreme":25580,"size":15,"leadingEdge":["STAT1","AMER1","SIX1"]} {"pathway":"GO_DENDRITIC_CELL_CYTOKINE_PRODUCTION","pval":0.47711,"padj":0.91258,"ES":0.90789,"NES":1.14968,"nMoreExtreme":27242,"size":11,"leadingEdge":["NOD2","JAK3","TLR3","DDX58","TLR4","TICAM1","BST2"]} {"pathway":"GO_REGULATION_OF_TRANSMEMBRANE_TRANSPORT","pval":0.11612,"padj":0.70006,"ES":0.63953,"NES":1.1496,"nMoreExtreme":10978,"size":384,"leadingEdge":["ATP1B2","P2RX7","CXCL11","PDE4B","CXCL10","SLC31A2","CXCL9","KCNJ10","AGT","KCNJ2","CAMK2D","KCNJ15","SRI","C3","RASGRF1","ABCB1","CTSS","TMEM109","EDN1","ANK2","CLIC5","DYSF","LYN","NR4A3","KCNE5","ANXA3","RNF207","STAC3","RSC1A1","JPH4","TNF","SLC8A1","SCN9A","AZIN2","GEM","PTAFR","KCNE1","PSEN2","CACNA1I","TGFB1","KCNMA1","HVCN1","RHOQ","ACTN2","CX3CL1","RGS9","NFE2L2","MIR212","CLIC2","GLRX","KCNE1B","STOM","SHISA7","EDNRA","S100A1","ARC","MAPK8IP2","KCNMB1"]} {"pathway":"GO_MEMBRANE_REPOLARIZATION_DURING_VENTRICULAR_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL","pval":0.4541,"padj":0.90517,"ES":0.90779,"NES":1.14955,"nMoreExtreme":26193,"size":12,"leadingEdge":["KCNE5","RNF207","KCNE1","KCNE1B","KCNQ1"]} {"pathway":"GO_DETECTION_OF_VISIBLE_LIGHT","pval":0.30815,"padj":0.86308,"ES":0.8321,"NES":1.14939,"nMoreExtreme":19813,"size":27,"leadingEdge":["GUCA1A","OPN3"]} {"pathway":"GO_IMMUNOGLOBULIN_PRODUCTION","pval":0.22019,"padj":0.80441,"ES":0.70867,"NES":1.14935,"nMoreExtreme":16886,"size":86,"leadingEdge":["CD40","TBX21","HLA-DQB1","HLA-E","TNFSF13B","POLB","GCNT3","BCL6","PARP3","IL6","TNF","PTPRC","NBN","TGFB1","CGAS","CCR6","LIG4","IL33"]} {"pathway":"GO_WNT_SIGNALING_PATHWAY_INVOLVED_IN_MIDBRAIN_DOPAMINERGIC_NEURON_DIFFERENTIATION","pval":0.51437,"padj":0.92459,"ES":0.90532,"NES":1.14933,"nMoreExtreme":29033,"size":10,"leadingEdge":["WNT1","LRP6"]} {"pathway":"GO_NK_T_CELL_PROLIFERATION","pval":0.6054,"padj":0.94703,"ES":0.87857,"NES":1.14924,"nMoreExtreme":32906,"size":7,"leadingEdge":["IL15","ELF4"]} {"pathway":"GO_IMMUNOLOGICAL_MEMORY_FORMATION_PROCESS","pval":0.59057,"padj":0.94268,"ES":0.89037,"NES":1.14921,"nMoreExtreme":32540,"size":8,"leadingEdge":["IL12RB1","BCL6","IFNL1"]} {"pathway":"GO_IMMUNOLOGICAL_MEMORY_PROCESS","pval":0.56544,"padj":0.93517,"ES":0.8997,"NES":1.1492,"nMoreExtreme":31598,"size":9,"leadingEdge":["IL12RB1","BCL6","TNFRSF14","IFNL1"]} {"pathway":"GO_REGULATION_OF_KERATINOCYTE_DIFFERENTIATION","pval":0.31319,"padj":0.86489,"ES":0.83686,"NES":1.14896,"nMoreExtreme":20038,"size":26,"leadingEdge":["CTSL","CYP27B1","RUNX1","FOXC1","ZFP36","PRKCH"]} {"pathway":"GO_MUSCLE_FILAMENT_SLIDING","pval":0.3342,"padj":0.87575,"ES":0.85246,"NES":1.14877,"nMoreExtreme":21026,"size":23,"leadingEdge":["MYH7","DES","ACTN2","VIM"]} {"pathway":"GO_PROTEIN_POLYGLUTAMYLATION","pval":0.56803,"padj":0.93727,"ES":0.89925,"NES":1.14862,"nMoreExtreme":31743,"size":9,"leadingEdge":["TTLL7","CFAP20"]} {"pathway":"GO_POSITIVE_REGULATION_OF_URINE_VOLUME","pval":0.48499,"padj":0.91689,"ES":0.90667,"NES":1.14812,"nMoreExtreme":27692,"size":11,"leadingEdge":["NPR1","EDN1","HAS2","ADORA2A"]} {"pathway":"GO_REGULATION_OF_BLOOD_PRESSURE","pval":0.20122,"padj":0.79334,"ES":0.68466,"NES":1.1481,"nMoreExtreme":16297,"size":121,"leadingEdge":["GCH1","ERAP2","SUCNR1","AGT","P2RX4","NPR1","EDN1","VEGFC","SOD2","CTSZ","ADM2","PTAFR","NAMPT","GUCY1A1","PTGS2","GAS6","CES1","AGTRAP","ERAP1","PDGFB","SMAD3","KLK1","SCPEP1","EDNRA"]} {"pathway":"GO_REGULATION_OF_NEURON_PROJECTION_REGENERATION","pval":0.30069,"padj":0.85813,"ES":0.82149,"NES":1.14771,"nMoreExtreme":19512,"size":29,"leadingEdge":["HGF","KREMEN1","KLF4","SCARF1","RGMA"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_LITHIUM_ION","pval":0.48776,"padj":0.91689,"ES":0.90632,"NES":1.14769,"nMoreExtreme":27850,"size":11,"leadingEdge":["LIG4","FABP4","CDH1"]} {"pathway":"GO_WHITE_FAT_CELL_DIFFERENTIATION","pval":0.48776,"padj":0.91689,"ES":0.90632,"NES":1.14769,"nMoreExtreme":27850,"size":11,"leadingEdge":["FGF10","FABP4","SNAI2"]} {"pathway":"GO_RENAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE","pval":0.43766,"padj":0.90126,"ES":0.89826,"NES":1.14766,"nMoreExtreme":26006,"size":15,"leadingEdge":["SUCNR1","AGT","GAS6","PDGFB"]} {"pathway":"GO_DETECTION_OF_MOLECULE_OF_BACTERIAL_ORIGIN","pval":0.52457,"padj":0.92669,"ES":0.90388,"NES":1.1475,"nMoreExtreme":29609,"size":10,"leadingEdge":["C4B","NOD2","TLR4","TLR1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_POSTTRANSCRIPTIONAL_GENE_SILENCING","pval":0.32808,"padj":0.87136,"ES":0.84606,"NES":1.14748,"nMoreExtreme":20777,"size":24,"leadingEdge":["STAT3","TRIM71","TGFB1","LIN28A","ZFP36","PUM2"]} {"pathway":"GO_REGULATION_OF_AMINO_ACID_TRANSPORT","pval":0.3631,"padj":0.89036,"ES":0.86906,"NES":1.14733,"nMoreExtreme":22444,"size":20,"leadingEdge":["P2RX7","AGT","KMO","ADORA2A"]} {"pathway":"GO_COLLAGEN_BIOSYNTHETIC_PROCESS","pval":0.27598,"padj":0.83925,"ES":0.78613,"NES":1.14701,"nMoreExtreme":18660,"size":38,"leadingEdge":["CIITA","IL6","TGFB1","VIM"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_2_PRODUCTION","pval":0.37551,"padj":0.89036,"ES":0.87468,"NES":1.14694,"nMoreExtreme":23062,"size":19,"leadingEdge":["GBP1","LAG3","TBX21","TNFAIP3","PTPRC","GATA3","ZFP36"]} {"pathway":"GO_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION","pval":0.20043,"padj":0.79183,"ES":0.68062,"NES":1.14684,"nMoreExtreme":16380,"size":128,"leadingEdge":["CXCL10","CXCL9","BHLHE41","FLT3LG","EDN1","SOD2","TRIM72","PAK1","TGFB1","ADGRB1","RIPOR2","CFLAR","CD53","PDGFB","SIK1","BOC","FLOT1","NFATC1","EREG","TBX1","PROX1","MAPK11","HDAC4","SMARCD3","EHD1"]} {"pathway":"GO_FEMALE_MATING_BEHAVIOR","pval":0.54206,"padj":0.9293,"ES":0.80507,"NES":1.14645,"nMoreExtreme":28211,"size":4,"leadingEdge":["NCOA1","THRA"]} {"pathway":"GO_SKELETAL_MUSCLE_CONTRACTION","pval":0.29862,"padj":0.85717,"ES":0.81604,"NES":1.14613,"nMoreExtreme":19466,"size":30,"leadingEdge":["KCNJ2","MYH7","STAC3","RCSD1"]} {"pathway":"GO_DENTATE_GYRUS_DEVELOPMENT","pval":0.49664,"padj":0.91907,"ES":0.90497,"NES":1.14598,"nMoreExtreme":28357,"size":11,"leadingEdge":["PROX1","BTG2","CDK6"]} {"pathway":"GO_PROTEIN_O_LINKED_GLYCOSYLATION_VIA_SERINE","pval":0.53194,"padj":0.92816,"ES":0.90267,"NES":1.14598,"nMoreExtreme":30025,"size":10,"leadingEdge":["GALNT3","GALNT16"]} {"pathway":"GO_REGULATION_OF_DEFENSE_RESPONSE_TO_BACTERIUM","pval":0.45573,"padj":0.90517,"ES":0.90429,"NES":1.14589,"nMoreExtreme":26541,"size":13,"leadingEdge":["SIGLEC11","SIGLEC16","GRN"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY","pval":0.25468,"padj":0.82751,"ES":0.75201,"NES":1.14589,"nMoreExtreme":17991,"size":51,"leadingEdge":["BCL2L11","PMAIP1","PTPN2","MCL1","PLEKHF1","NKX3-1","BAD"]} {"pathway":"GO_DOPAMINE_METABOLIC_PROCESS","pval":0.42217,"padj":0.89612,"ES":0.89195,"NES":1.14586,"nMoreExtreme":25288,"size":16,"leadingEdge":["NPR1","NR4A2","SNCAIP"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY","pval":0.49888,"padj":0.91907,"ES":0.90471,"NES":1.14565,"nMoreExtreme":28485,"size":11,"leadingEdge":["DYSF","GEM","GPR35"]} {"pathway":"GO_SMOOTH_MUSCLE_CELL_DIFFERENTIATION","pval":0.25235,"padj":0.82744,"ES":0.74613,"NES":1.14539,"nMoreExtreme":17962,"size":54,"leadingEdge":["COMP","SOD2","FGF10","TGFB1","PDGFB","NFATC1","EREG","SMARCD3","SIX1"]} {"pathway":"GO_CARDIOBLAST_DIFFERENTIATION","pval":0.45832,"padj":0.90517,"ES":0.90384,"NES":1.14532,"nMoreExtreme":26692,"size":13,"leadingEdge":["PRICKLE1","REST"]} {"pathway":"GO_REGULATION_OF_COLLAGEN_BIOSYNTHETIC_PROCESS","pval":0.29966,"padj":0.85717,"ES":0.81544,"NES":1.14528,"nMoreExtreme":19534,"size":30,"leadingEdge":["CIITA","IL6","TGFB1","VIM"]} {"pathway":"GO_REGULATION_OF_TRANSLATIONAL_INITIATION_IN_RESPONSE_TO_STRESS","pval":0.45466,"padj":0.90517,"ES":0.89996,"NES":1.14528,"nMoreExtreme":26761,"size":14,"leadingEdge":["EIF2AK2","NCK2"]} {"pathway":"GO_CALCIUM_ION_REGULATED_EXOCYTOSIS","pval":0.20605,"padj":0.79637,"ES":0.68292,"NES":1.14518,"nMoreExtreme":16688,"size":121,"leadingEdge":["P2RX7","LRRK2","STX11","GRIN3A","ERC2","PRRT2","SCIN","DTNBP1","CADPS2","CACNA1I","TRIM9","ARHGAP17","SYT5","NAPA","STX3","SYT17"]} {"pathway":"GO_EXPLORATION_BEHAVIOR","pval":0.40568,"padj":0.89503,"ES":0.88546,"NES":1.14509,"nMoreExtreme":24514,"size":17,"leadingEdge":["LRRK2","SLC4A10","ITGA3"]} {"pathway":"GO_ATRIAL_SEPTUM_DEVELOPMENT","pval":0.44089,"padj":0.90126,"ES":0.89625,"NES":1.14508,"nMoreExtreme":26198,"size":15,"leadingEdge":["ANK2","NOTCH2","TGFB2"]} {"pathway":"GO_CELL_PROLIFERATION_INVOLVED_IN_HEART_MORPHOGENESIS","pval":0.44099,"padj":0.90126,"ES":0.89619,"NES":1.145,"nMoreExtreme":26204,"size":15,"leadingEdge":["PIM1","SIX1","MKS1"]} {"pathway":"GO_CARDIAC_CHAMBER_FORMATION","pval":0.53674,"padj":0.92816,"ES":0.90183,"NES":1.14491,"nMoreExtreme":30296,"size":10,"leadingEdge":["SMARCD3","MEF2C"]} {"pathway":"GO_REGULATION_OF_LONG_TERM_SYNAPTIC_DEPRESSION","pval":0.53742,"padj":0.92855,"ES":0.90172,"NES":1.14476,"nMoreExtreme":30334,"size":10,"leadingEdge":["ARC","LILRB2","FMR1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS","pval":0.37802,"padj":0.89036,"ES":0.87284,"NES":1.14454,"nMoreExtreme":23216,"size":19,"leadingEdge":["AGT","TNF","SREBF1"]} {"pathway":"GO_LIPID_PHOSPHORYLATION","pval":0.24616,"padj":0.82387,"ES":0.73708,"NES":1.14449,"nMoreExtreme":17781,"size":59,"leadingEdge":["SOCS1","CISH","TMEM150A","DGKG","SOCS3","AGK"]} {"pathway":"GO_POSITIVE_REGULATION_OF_GTPASE_ACTIVITY","pval":0.13079,"padj":0.72638,"ES":0.63835,"NES":1.14446,"nMoreExtreme":12285,"size":358,"leadingEdge":["CD40","LRRK2","CCL13","TAGAP","CCL7","ICAM1","ARAP2","CCL15","VPS9D1","RSU1","CCL8","RASGRF1","RAPGEF2","USP6NL","S100A10","CCL18","CCL5","DENND1B","ARHGAP25","RASGEF1B","RASGRP1","CCL1","CCL4","CCL2","ARHGAP17","TBC1D2B","CDC42EP2","CCL19","CCL3","RGS1","CX3CL1","RGS9","SEMA4D","PLCB1","ELMOD1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_SUMOYLATION","pval":0.50497,"padj":0.91988,"ES":0.90374,"NES":1.14441,"nMoreExtreme":28833,"size":11,"leadingEdge":["HDAC4","PIAS1"]} {"pathway":"GO_HISTONE_H4_DEACETYLATION","pval":0.50497,"padj":0.91988,"ES":0.90374,"NES":1.14441,"nMoreExtreme":28833,"size":11,"leadingEdge":["HDAC4","HDAC9"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_LIPID","pval":0.10638,"padj":0.68387,"ES":0.63257,"NES":1.14438,"nMoreExtreme":10236,"size":480,"leadingEdge":["CD40","CD274","CXCL11","PDCD1LG2","IL15","PDE4B","CXCL10","NOD2","ACOD1","CXCL9","SSTR2","PADI2","JAK2","PIM1","RIPK2","ICAM1","PAQR8","KLF4","BCL2L11","CD80","ZC3H12A","CARD17","STAP1","CARD16","GRAMD1B","EDN1","FAM107A","LILRA2","IL1RN","SBNO2","DGAT2","PTGER4","CMPK2","LITAF","CCL5","LYN","TICAM2","EPHX1","NR4A3","PLSCR4","TNFAIP3","IL6","TNF","PTGER2","CD86","HNF4G","CCR5","NCOA1","CYP27B1","PTAFR","NR1H3","NR4A2","LILRB1","CCL2","KMO","PAK1","RUNX1","SRC","TGFB1","CXCL8","NFKBIA","LPAR1","CREBRF","PLPP1","CCL3","CX3CL1","CFLAR","CASP1","NKX3-1","PPARGC1B"]} {"pathway":"GO_CELL_AGGREGATION","pval":0.48132,"padj":0.91676,"ES":0.90368,"NES":1.14434,"nMoreExtreme":27763,"size":12,"leadingEdge":["MPZ","PKD1"]} {"pathway":"GO_CD4_POSITIVE_OR_CD8_POSITIVE_ALPHA_BETA_T_CELL_LINEAGE_COMMITMENT","pval":0.39231,"padj":0.89503,"ES":0.87859,"NES":1.14423,"nMoreExtreme":23868,"size":18,"leadingEdge":["IL12RB1","TBX21","SLAMF6","CYLD","IRF4","IL6","STAT3"]} {"pathway":"GO_NEURON_DEATH_IN_RESPONSE_TO_OXIDATIVE_STRESS","pval":0.31951,"padj":0.86901,"ES":0.8332,"NES":1.14393,"nMoreExtreme":20442,"size":26,"leadingEdge":["NR4A3","MCL1","TLR4","WNT1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INFLAMMATORY_RESPONSE","pval":0.21114,"padj":0.79831,"ES":0.68527,"NES":1.14389,"nMoreExtreme":16968,"size":115,"leadingEdge":["GBP5","IDO1","LRRK2","IL15","NOD2","HLA-E","JAK2","SUCNR1","AGT","TGM2","C3","TLR10","STAP1","PTGER4","CCL18","TLR7","LTA","MYD88","IL6","TLR3","TNF","CD47","CCL1","NFKBIA","PTGS2","CCL3","CX3CL1","IL33"]} {"pathway":"GO_POSITIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY","pval":0.19001,"padj":0.78784,"ES":0.6673,"NES":1.14385,"nMoreExtreme":16055,"size":159,"leadingEdge":["TNFSF10","ATF3","JAK2","AGT","FAS","BCL2L11","PML","CYLD","PMAIP1","RBCK1","PTPRC","PTPN2","CTSC","MCL1","PLEKHF1","NKX3-1","BBC3","SMAD3","BAK1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INTERLEUKIN_6_BIOSYNTHETIC_PROCESS","pval":0.48449,"padj":0.91689,"ES":0.90317,"NES":1.1437,"nMoreExtreme":27946,"size":12,"leadingEdge":["TNF","PTAFR","STAT3","EREG","TLR1","TYROBP"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT","pval":0.22786,"padj":0.81476,"ES":0.70355,"NES":1.14363,"nMoreExtreme":17524,"size":88,"leadingEdge":["P2RX7","CXCL11","CXCL10","CXCL9","SRI","P2RX4","LILRA2","ANK2","CCL5","STAC3","CXCL12","CCL4","CCL2","CCL3","CX3CL1","PDGFB","BAK1","LILRA5","S100A1","CCR1"]} {"pathway":"GO_TROPHECTODERMAL_CELL_DIFFERENTIATION","pval":0.51044,"padj":0.92413,"ES":0.90295,"NES":1.14342,"nMoreExtreme":29145,"size":11,"leadingEdge":["HOPX","JUNB","CUL3"]} {"pathway":"GO_NEUROENDOCRINE_CELL_DIFFERENTIATION","pval":0.60563,"padj":0.94703,"ES":0.85494,"NES":1.1432,"nMoreExtreme":32503,"size":6,"leadingEdge":["ASCL1","BCCIP"]} {"pathway":"GO_CHONDROCYTE_DIFFERENTIATION_INVOLVED_IN_ENDOCHONDRAL_BONE_MORPHOGENESIS","pval":0.34901,"padj":0.88316,"ES":0.85378,"NES":1.14305,"nMoreExtreme":21837,"size":22,"leadingEdge":["SMPD3","COCH","COL27A1"]} {"pathway":"GO_NEUROTRANSMITTER_UPTAKE","pval":0.29643,"padj":0.85691,"ES":0.80525,"NES":1.14284,"nMoreExtreme":19493,"size":32,"leadingEdge":["KCNJ10","SLC18A1","GLUL","GPM6B","FLOT1"]} {"pathway":"GO_REGULATION_OF_TRANSLATIONAL_INITIATION_BY_EIF2_ALPHA_PHOSPHORYLATION","pval":0.54773,"padj":0.93115,"ES":0.89998,"NES":1.14255,"nMoreExtreme":30916,"size":10,"leadingEdge":["EIF2AK2","NCK2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY","pval":0.51538,"padj":0.92459,"ES":0.9021,"NES":1.14235,"nMoreExtreme":29427,"size":11,"leadingEdge":["JAK2","FAS","SMAD3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS","pval":0.21637,"padj":0.80167,"ES":0.68638,"NES":1.14212,"nMoreExtreme":17292,"size":111,"leadingEdge":["LAMP3","ATP13A2","PML","DYSF","AZIN2","ADGRB1","SMAD3","AGAP2","WNT1"]} {"pathway":"GO_LYMPHOCYTE_APOPTOTIC_PROCESS","pval":0.24701,"padj":0.82387,"ES":0.72968,"NES":1.1421,"nMoreExtreme":18040,"size":63,"leadingEdge":["IDO1","CD74","P2RX7","CD274","BCL2L11","PDCD1","JAK3","GIMAP8","BCL6","CCL5","LYN","IL2RA","PRELID1","BIRC7","BAK1"]} {"pathway":"GO_POTASSIUM_ION_EXPORT_ACROSS_PLASMA_MEMBRANE","pval":0.49368,"padj":0.91907,"ES":0.90162,"NES":1.14174,"nMoreExtreme":28476,"size":12,"leadingEdge":["KCNE5","KCNE1","KCNE1B","KCNQ1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_DEPHOSPHORYLATION","pval":0.2825,"padj":0.84533,"ES":0.78251,"NES":1.14173,"nMoreExtreme":19101,"size":38,"leadingEdge":["JAK2","PTPRC","TGFB1","PPP1R16B","LILRB2"]} {"pathway":"GO_OTIC_VESICLE_DEVELOPMENT","pval":0.49372,"padj":0.91907,"ES":0.9016,"NES":1.14171,"nMoreExtreme":28478,"size":12,"leadingEdge":["FGF10","GATA3","PROX1","SIX1"]} {"pathway":"GO_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY","pval":0.29799,"padj":0.85717,"ES":0.80439,"NES":1.14162,"nMoreExtreme":19596,"size":32,"leadingEdge":["LAG3","HLA-F","CEACAM1","HLA-E","SLAMF6","HLA-G","IL12A","SERPINB9","CD226","RASGRP1","LILRB1","MICB","IL18RAP"]} {"pathway":"GO_GLUTATHIONE_METABOLIC_PROCESS","pval":0.305,"padj":0.86182,"ES":0.81272,"NES":1.14148,"nMoreExtreme":19882,"size":30,"leadingEdge":["GSTK1","CTNS","GGT5","MGST1"]} {"pathway":"GO_REGULATION_OF_T_CELL_CHEMOTAXIS","pval":0.51939,"padj":0.92533,"ES":0.90136,"NES":1.14141,"nMoreExtreme":29656,"size":11,"leadingEdge":["CXCL10","CCL5","WNK1"]} {"pathway":"GO_CD4_POSITIVE_ALPHA_BETA_T_CELL_CYTOKINE_PRODUCTION","pval":0.42868,"padj":0.89886,"ES":0.88757,"NES":1.14023,"nMoreExtreme":25678,"size":16,"leadingEdge":["IL31RA","TBX21","RSAD2","DENND1B","IL6","GATA3","IL18RAP"]} {"pathway":"GO_ANTIMICROBIAL_HUMORAL_RESPONSE","pval":0.27499,"padj":0.83769,"ES":0.76708,"NES":1.1401,"nMoreExtreme":18934,"size":43,"leadingEdge":["CXCL11","CXCL10","CCL13","HLA-E","ACOD1","CXCL9","CXCL8"]} {"pathway":"GO_POSTTRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION","pval":0.10139,"padj":0.67298,"ES":0.62841,"NES":1.14006,"nMoreExtreme":9840,"size":542,"leadingEdge":["PSME2","PSMB9","PSME1","BANK1","PSMB10","PSMB8","XRN1","SAMD4A","ZC3H12A","PIWIL4","MIR503","CCL5","PARP9","MYD88","IL6","TNF","PSMA4","PSMA2","MOV10","PTAFR","STAT3","TRIM71","TGFB1","PSMA5","ADAR","TDRD7","LIN28A","MIR212","SMAD3","ZFP36"]} {"pathway":"GO_NEUROTROPHIN_SIGNALING_PATHWAY","pval":0.28875,"padj":0.84958,"ES":0.78797,"NES":1.14001,"nMoreExtreme":19342,"size":36,"leadingEdge":["AGT","RAPGEF2","SRC","SORT1","NGF","HAP1"]} {"pathway":"GO_AXO_DENDRITIC_PROTEIN_TRANSPORT","pval":0.50172,"padj":0.91978,"ES":0.90019,"NES":1.13993,"nMoreExtreme":28940,"size":12,"leadingEdge":["KIF17","RAB27B"]} {"pathway":"GO_REGULATION_OF_BRANCHING_INVOLVED_IN_SALIVARY_GLAND_MORPHOGENESIS","pval":0.57993,"padj":0.94163,"ES":0.89243,"NES":1.1399,"nMoreExtreme":32408,"size":9,"leadingEdge":["HGF","FGF10","TNF","BTBD7"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TELOMERASE_ACTIVITY","pval":0.5588,"padj":0.93517,"ES":0.89788,"NES":1.13989,"nMoreExtreme":31541,"size":10,"leadingEdge":["PARP3","SRC","POT1"]} {"pathway":"GO_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL","pval":0.24184,"padj":0.82373,"ES":0.7131,"NES":1.13983,"nMoreExtreme":18159,"size":75,"leadingEdge":["P2RX7","CXCL11","CXCL10","CXCL9","CAMK2D","PML","SRI","P2RX4","ANK2","LYN","JPH4","SLC8A1","TGFB1","CX3CL1","CLIC2","BAK1"]} {"pathway":"GO_EOSINOPHIL_CHEMOTAXIS","pval":0.41263,"padj":0.89503,"ES":0.88107,"NES":1.13942,"nMoreExtreme":24934,"size":17,"leadingEdge":["CCL13","CCL7","CCL15","CCL8","CCL5","CCL1","CCL4","CCL2","CCL3","CX3CL1","DAPK2"]} {"pathway":"GO_OLIGOSACCHARIDE_BIOSYNTHETIC_PROCESS","pval":0.48425,"padj":0.91689,"ES":0.89912,"NES":1.13934,"nMoreExtreme":28202,"size":13,"leadingEdge":["B3GALT5","FUT8"]} {"pathway":"GO_INTERLEUKIN_2_PRODUCTION","pval":0.25986,"padj":0.8287,"ES":0.7402,"NES":1.13885,"nMoreExtreme":18551,"size":55,"leadingEdge":["GBP1","LAG3","PDE4B","TBX21","RIPK2","CD80","CD83","IRF4","TNFAIP3","CD86","PTPRC","RUNX1","GATA3","ZFP36","IL1A","FCER1G"]} {"pathway":"GO_RESPONSE_TO_STARVATION","pval":0.19851,"padj":0.79183,"ES":0.66428,"NES":1.13869,"nMoreExtreme":16773,"size":159,"leadingEdge":["LRRK2","ATF3","SSTR2","FAS","ZC3H12A","RALB","PMAIP1","GLUL","CADPS2","SIK1B","NUAK2","CDKN1A","UCP2","RRAGC","GAS6","ASNS","RRAGD","NFE2L2","ZFP36","SIK1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MOLECULAR_FUNCTION","pval":0.05905,"padj":0.58367,"ES":0.62317,"NES":1.13867,"nMoreExtreme":5857,"size":870,"leadingEdge":["IL18BP","AIM2","C4A","SOCS1","LRRK2","C4B","SERPING1","LAMP3","CEACAM1","AMOT","HGF","NLRC5","ACOD1","DKK2","LMTK2","JAK2","AGT","PIM1","PZP","CAMK2D","KLF4","SRI","B2M","C3","ZC3H12A","PARP10","CYLD","IFIT2","CARD17","CARD16","XIRP1","RALB","DTX3L","MVP","GADD45B","DYSF","PPM1E","LYN","DTNBP1","PARP3","PARP9","KCNE5","IL7","TNFAIP3","ANXA3","BIRC3","CTSZ","TNF","TEX14","P2RY13","SERPINB9","RBCK1","DUSP10","LY6E","GEM","CYP27B1","PTPRC","RHOH","KCNE1","SOCS3","PTPN2","ANGPTL4","SRC","A2M","CDKN1A","SNX16","TXNIP","TRIM21","ADAR","DUSP5","CDKN1C","UBE2Z","PTPN1","SORT1","NFKBIA","ACTN2","MAP2","IFI6","PKHD1","SH3RF1","PTGS2","RIPOR2","ELFN1","GAS6","CFLAR","MITD1","BIRC7","NKX3-1","SRCIN1","MIR212","SEMA4D","SERPINB1","SPINK1","HERPUD1","CLIC2","PDGFB","NFKBIE","HMSD","ZFP36","SLIT2","KCNE1B","SIK1","MYOZ1","NGF","TNFAIP8","C9orf72"]} {"pathway":"GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS","pval":0.24381,"padj":0.82387,"ES":0.71233,"NES":1.13859,"nMoreExtreme":18307,"size":75,"leadingEdge":["HGF","TNFSF10","ATF3","FAS","ICAM1","PMAIP1","TNFAIP3","TNF","SORT1","CFLAR","NGF"]} {"pathway":"GO_REGULATION_OF_B_CELL_PROLIFERATION","pval":0.26594,"padj":0.83608,"ES":0.74936,"NES":1.13838,"nMoreExtreme":18705,"size":50,"leadingEdge":["CD40","CD74","CD38","CTLA4","TNFSF13B","BCL6","LYN","IL7","PTPRC","MNDA"]} {"pathway":"GO_METAL_ION_TRANSPORT","pval":0.09281,"padj":0.66428,"ES":0.62565,"NES":1.13815,"nMoreExtreme":9081,"size":615,"leadingEdge":["ATP1B2","P2RX7","CXCL11","PDE4B","CXCL10","SLC31A2","CXCL9","LMTK2","GRIN3A","KCNJ10","AGT","STEAP4","SLC12A3","KCNJ2","MCOLN2","CAMK2D","SPTBN4","ICAM1","KCNJ15","FLVCR2","PML","SRI","B2M","CCL8","P2RX4","SCO2","LILRA2","SLC25A28","ANK2","DYSF","CCL5","LYN","KCNE5","RNF207","STAC3","JPH4","SLC8A1","HPN","TCN2","SCN9A","CCR5","SLC12A7","CXCL12","GEM","CYP27B1","PTPRC","BSPRY","SLC25A25","SLC4A10","CCL4","LILRB1","KCNE1","PSEN2","CCL2","CACNA1I","P2RY12","TGFB1","KCNMA1","CCL19","ATP6V1A","ACTN2","PTGS2","GAS6","PARL","CCL3","CX3CL1","RGS9","MIR212","SPINK1","PLCB1","CLIC2","SLC8A2","PDGFB","GLRX","KCNE1B","BAK1","STOM","SIK1","LILRA5","S100A1","SLC31A1","CCR1","KCNMB1","SLC9A4"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR","pval":0.46809,"padj":0.90738,"ES":0.89431,"NES":1.13809,"nMoreExtreme":27551,"size":14,"leadingEdge":["CD74","KDM1A"]} {"pathway":"GO_RESPONSE_TO_DSRNA","pval":0.28735,"padj":0.84886,"ES":0.77994,"NES":1.13798,"nMoreExtreme":19429,"size":38,"leadingEdge":["P2RX7","RIPK2","RALB","IFIH1","PMAIP1","TLR3","DDX58","CGAS","NFKBIA","FLOT1","TICAM1"]} {"pathway":"GO_REGULATION_OF_IMMUNOGLOBULIN_PRODUCTION","pval":0.26314,"padj":0.83229,"ES":0.74103,"NES":1.13756,"nMoreExtreme":18730,"size":54,"leadingEdge":["CD40","TBX21","HLA-E","BCL6","PARP3","IL6","TNF","PTPRC","TGFB1","CGAS","IL33"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NEURON_MIGRATION","pval":0.44974,"padj":0.90517,"ES":0.88999,"NES":1.13708,"nMoreExtreme":26724,"size":15,"leadingEdge":["RAPGEF2","SEMA3A"]} {"pathway":"GO_PURINERGIC_NUCLEOTIDE_RECEPTOR_SIGNALING_PATHWAY","pval":0.40059,"padj":0.89503,"ES":0.87286,"NES":1.13678,"nMoreExtreme":24372,"size":18,"leadingEdge":["P2RY14","P2RX7","P2RX4","P2RY13","PTAFR","P2RY12","P2RY2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELL_DIFFERENTIATION","pval":0.10679,"padj":0.68464,"ES":0.62638,"NES":1.13645,"nMoreExtreme":10366,"size":545,"leadingEdge":["IRF1","ASCL2","GBP1","CD74","SOCS1","LRRK2","CD38","TBX21","CXCL10","CEACAM1","KREMEN1","CHRD","STAT1","CTLA4","TMEM176A","TMEM176B","BHLHE41","LILRB3","B2M","ZC3H12A","JAK3","RAPGEF2","STAP1","HLA-G","DYNLT1","BCL6","LYN","CTSZ","IL6","TLR3","LILRB4","FGF10","SEMA7A","TNF","SOX8","HPN","DUSP10","HOPX","TRIM72","ASCL1","NTN1","NR1H3","LILRB1","STAT3","P2RY12","PTPN2","PAK1","RUNX1","TGFB1","SEMA4A","C1QC","ISL2","SORT1","NFKBIA","MAP2","RGMA","LPAR1","CCL3","CX3CL1","AP1AR","CFLAR","GATA3","NFE2L2","LIN28A","SEMA4D","PDGFB","SMAD3","DENND5A","ZFP36","SLIT2","RORB","TRIM46","HLX","ESRRB"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PROTEIN_POLYMERIZATION","pval":0.25669,"padj":0.82758,"ES":0.72874,"NES":1.13644,"nMoreExtreme":18654,"size":61,"leadingEdge":["SPTBN4","SCIN","TMSB10","MAP2","SPTA1","SLIT2","FKBP4"]} {"pathway":"GO_VESICLE_BUDDING_FROM_MEMBRANE","pval":0.2356,"padj":0.81978,"ES":0.69233,"NES":1.13589,"nMoreExtreme":18383,"size":96,"leadingEdge":["P2RX7","S100A10","CTSZ","CTSC","NAPA","RILP"]} {"pathway":"GO_NEUROTRANSMITTER_METABOLIC_PROCESS","pval":0.23578,"padj":0.81994,"ES":0.69224,"NES":1.13573,"nMoreExtreme":18397,"size":96,"leadingEdge":["GCH1","JAK2","AGT","DPYS","ICAM1","KLF4","ZC3H12A","P2RX4","EDN1","COLQ","TNF","CD47","SLC7A2","PTGS2","MIR212","SMAD3","TLR4","ASS1"]} {"pathway":"GO_T_CELL_CYTOKINE_PRODUCTION","pval":0.29902,"padj":0.85717,"ES":0.79214,"NES":1.13563,"nMoreExtreme":19850,"size":34,"leadingEdge":["IL31RA","TBX21","HLA-F","B2M","RSAD2","DENND1B","IL6","GATA3","IL18RAP"]} {"pathway":"GO_PYRIMIDINE_CONTAINING_COMPOUND_CATABOLIC_PROCESS","pval":0.30656,"padj":0.86306,"ES":0.80011,"NES":1.13555,"nMoreExtreme":20159,"size":32,"leadingEdge":["DPYS","TYMP","APOBEC3D","APOBEC3A","APOBEC3G","APOBEC3F"]} {"pathway":"GO_REGULATION_OF_POSTSYNAPTIC_NEUROTRANSMITTER_RECEPTOR_INTERNALIZATION","pval":0.58267,"padj":0.94167,"ES":0.88897,"NES":1.13548,"nMoreExtreme":32561,"size":9,"leadingEdge":["ARC","DRD4"]} {"pathway":"GO_CATION_TRANSPORT","pval":0.07323,"padj":0.62434,"ES":0.62169,"NES":1.13518,"nMoreExtreme":7248,"size":794,"leadingEdge":["ATP1B2","P2RX7","CXCL11","PDE4B","CXCL10","ATP13A2","SLC31A2","CXCL9","LMTK2","GRIN3A","KCNJ10","AGT","STEAP4","SLC12A3","KCNJ2","MCOLN2","CAMK2D","SPTBN4","ICAM1","VPS9D1","KCNJ15","FLVCR2","PML","SRI","B2M","CCL8","RASGRF1","CTSS","P2RX4","SLC2A6","EDN1","C15orf48","SCO2","LILRA2","SLC25A28","ANK2","SLC18A1","DYSF","CCL5","LYN","DTNBP1","SLC25A45","KCNE5","ANXA3","RNF207","STAC3","JPH4","SLC8A1","HPN","TCN2","SCN9A","AZIN2","CCR5","SLC12A7","CXCL12","GEM","CYP27B1","PTPRC","BSPRY","SLC25A25","SLC4A10","CCL4","LILRB1","KCNE1","PSEN2","CCL2","CACNA1I","P2RY12","TGFB1","KCNMA1","SYT5","CCL19","SLC22A1","UCP2","ATP6V1A","SLC7A2","CLCN4","HVCN1","ACTN2","GPM6B","PTGS2","GAS6","PARL","CCL3","CX3CL1","RGS9","TMEM63C","SLC44A2","MIR212","SPINK1","PLCB1","CLIC2","SLC8A2","PDGFB","NFKBIE","SYT17","GLRX","KCNE1B","BAK1","STOM","SIK1","FCER1G","LILRA5","SHISA7","S100A1","ARC","SLC31A1","MAPK8IP2","CCR1","KCNMB1","SLC9A4"]} {"pathway":"GO_RESPONSE_TO_HYPEROXIA","pval":0.43437,"padj":0.90066,"ES":0.88349,"NES":1.13499,"nMoreExtreme":26019,"size":16,"leadingEdge":["FAS","CYP1A1","POLB","CDKN1A"]} {"pathway":"GO_REGULATION_OF_CHLORIDE_TRANSPORT","pval":0.60825,"padj":0.94703,"ES":0.84875,"NES":1.13493,"nMoreExtreme":32644,"size":6,"leadingEdge":["ABCB1","PTAFR","ANO9"]} {"pathway":"GO_INTERACTION_WITH_HOST","pval":0.19597,"padj":0.79001,"ES":0.65561,"NES":1.13485,"nMoreExtreme":16883,"size":183,"leadingEdge":["CD74","IFITM2","ICAM1","BCL2L11","IFITM1","CD80","PML","CCL8","ZC3H12A","SLAMF1","TRIM31","IFITM3","CHMP4C","DYNLT1","KPNA5","HAVCR1","TNFRSF14","SERPINB9","CD86","CCR5","ITGB7","SRC","TGFB1","CXCL8","UVRAG","TRIM21","GUCY1A1","GAS6","TRIM25","SMAD3"]} {"pathway":"GO_ORGANELLE_FUSION","pval":0.22883,"padj":0.81508,"ES":0.68241,"NES":1.13483,"nMoreExtreme":18276,"size":110,"leadingEdge":["TAP2","TAP1","STX11","SAMD9L","TAPBP","PRRT2","RAB20","DYSF","VCPIP1","TRIM9","UVRAG","SAMD9","STX3","RAB39A","STX17","BAK1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_12_PRODUCTION","pval":0.45216,"padj":0.90517,"ES":0.88816,"NES":1.13475,"nMoreExtreme":26868,"size":15,"leadingEdge":["TLR8","MEFV","JAK3","SLAMF1","LILRB1","LILRA5"]} {"pathway":"GO_REGULATION_OF_TOLERANCE_INDUCTION","pval":0.49244,"padj":0.91907,"ES":0.89544,"NES":1.13468,"nMoreExtreme":28679,"size":13,"leadingEdge":["IDO1","CD274","PDCD1","HLA-G","IL2RA","LILRB2"]} {"pathway":"GO_VASCULAR_SMOOTH_MUSCLE_CONTRACTION","pval":0.3901,"padj":0.89435,"ES":0.86516,"NES":1.13447,"nMoreExtreme":23958,"size":19,"leadingEdge":["CD38","AGT","EDN1","COMP","SLC8A1","EDNRA"]} {"pathway":"GO_ANTIFUNGAL_INNATE_IMMUNE_RESPONSE","pval":0.29747,"padj":0.85705,"ES":0.85105,"NES":1.13433,"nMoreExtreme":14884,"size":1,"leadingEdge":["FAM3A"]} {"pathway":"GO_NERVE_GROWTH_FACTOR_SIGNALING_PATHWAY","pval":0.56293,"padj":0.93517,"ES":0.89335,"NES":1.13414,"nMoreExtreme":31774,"size":10,"leadingEdge":["RAPGEF2","SORT1","NGF"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MICROGLIAL_CELL_MIGRATION","pval":0.58831,"padj":0.94167,"ES":0.82441,"NES":1.13404,"nMoreExtreme":31129,"size":5,"leadingEdge":["P2RX4","CSF1","P2RY12","CCL3"]} {"pathway":"GO_CELLULAR_RESPIRATION","pval":0.20296,"padj":0.79569,"ES":0.65924,"NES":1.13396,"nMoreExtreme":17279,"size":167,"leadingEdge":["AIFM2","NR4A3","SLC25A22","SLC25A25","GPD2","PRELID1","SDHB","NDUFAB1"]} {"pathway":"GO_CIRCULATORY_SYSTEM_PROCESS","pval":0.14343,"padj":0.74253,"ES":0.63075,"NES":1.13383,"nMoreExtreme":13560,"size":384,"leadingEdge":["ATP1B2","GCH1","CD38","SERPING1","PDE4B","ERAP2","CXCL10","CEACAM1","STAT1","JAK2","SUCNR1","AGT","MYOF","KCNJ2","CAMK2D","SPTBN4","ICAM1","SRI","ZC3H12A","P2RX4","NPR1","GJD3","EDN1","VEGFC","ANK2","COMP","KCNE5","SOD2","MYH7","RNF207","CTSZ","PTGER2","SLC8A1","DES","ADM2","CXCL12","PTAFR","KCNE1","GCLC","SRC","TGFB1","KCNMA1","NAMPT","GUCY1A1","P2RY2","PTGS2","GAS6","CES1","FOXC1","GUCY1B1","AGTRAP","ERAP1","CLIC2","SLC8A2","PDGFB","SMAD3","KLK1","SLIT2","KCNE1B","SCPEP1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING","pval":0.54005,"padj":0.92877,"ES":0.89535,"NES":1.13379,"nMoreExtreme":30836,"size":11,"leadingEdge":["KLF4","BTN2A2","PIK3IP1"]} {"pathway":"GO_VESICLE_CYTOSKELETAL_TRAFFICKING","pval":0.27696,"padj":0.84047,"ES":0.75222,"NES":1.13339,"nMoreExtreme":19330,"size":47,"leadingEdge":["DTNBP1","RASGRP1","MAP2","TRIM46","HAP1","PAFAH1B1"]} {"pathway":"GO_INDUCTION_OF_POSITIVE_CHEMOTAXIS","pval":0.47354,"padj":0.90882,"ES":0.89054,"NES":1.1333,"nMoreExtreme":27872,"size":14,"leadingEdge":["VEGFC","FGF10","CXCL12","CXCL8","VEGFD"]} {"pathway":"GO_RIBONUCLEOSIDE_CATABOLIC_PROCESS","pval":0.41915,"padj":0.89569,"ES":0.8762,"NES":1.13313,"nMoreExtreme":25328,"size":17,"leadingEdge":["APOBEC3D","ENPP4","APOBEC3A","APOBEC3G","APOBEC3F","ADA2"]} {"pathway":"GO_PERIPHERAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION","pval":0.60015,"padj":0.94564,"ES":0.87777,"NES":1.13294,"nMoreExtreme":33068,"size":8,"leadingEdge":["ONECUT2","RUNX1","ISL2","RUNX3"]} {"pathway":"GO_REGULATION_OF_SYNCYTIUM_FORMATION_BY_PLASMA_MEMBRANE_FUSION","pval":0.355,"padj":0.88844,"ES":0.84035,"NES":1.13245,"nMoreExtreme":22335,"size":23,"leadingEdge":["CXCL10","CXCL9","FLT3LG","OCSTAMP","ADGRB1","RIPOR2","CFLAR","CD53","FLOT1","DCSTAMP","EHD1"]} {"pathway":"GO_RESPONSE_TO_IMMOBILIZATION_STRESS","pval":0.40585,"padj":0.89503,"ES":0.86937,"NES":1.13223,"nMoreExtreme":24692,"size":18,"leadingEdge":["CYP1A1","SLC8A1","TGFB1","ERCC1"]} {"pathway":"GO_PHOSPHOLIPID_TRANSPORT","pval":0.25688,"padj":0.82758,"ES":0.71284,"NES":1.13222,"nMoreExtreme":19117,"size":71,"leadingEdge":["P2RX7","ANO4","ABCB1","XKR6","PLSCR4","PLSCR1","XKR8","GLTPD2","MFSD2A","XKR7","PRELID1"]} {"pathway":"GO_APOPTOTIC_CELL_CLEARANCE","pval":0.28737,"padj":0.84886,"ES":0.76433,"NES":1.13191,"nMoreExtreme":19705,"size":42,"leadingEdge":["C4A","C4B","C2","TGM2","C3","CD300LF","XKR6","XKR8","NR1H3","CCL2","ADGRB1","GAS6","XKR7"]} {"pathway":"GO_CILIARY_NEUROTROPHIC_FACTOR_MEDIATED_SIGNALING_PATHWAY","pval":0.60919,"padj":0.94703,"ES":0.84631,"NES":1.13166,"nMoreExtreme":32694,"size":6,"leadingEdge":["EBI3","LIFR"]} {"pathway":"GO_REGULATION_OF_LIPASE_ACTIVITY","pval":0.25828,"padj":0.82758,"ES":0.71233,"NES":1.1314,"nMoreExtreme":19221,"size":71,"leadingEdge":["ITK","AGT","CCL5","FLT1","PTAFR","NR1H3","P2RY12","ANGPTL4","PDGFRA","SORT1","LPAR1","LMF1","EDNRA"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS","pval":0.45546,"padj":0.90517,"ES":0.88551,"NES":1.13136,"nMoreExtreme":27064,"size":15,"leadingEdge":["CD40","HLA-G","CCL2"]} {"pathway":"GO_HIPPO_SIGNALING","pval":0.29792,"padj":0.85717,"ES":0.77859,"NES":1.13121,"nMoreExtreme":20040,"size":37,"leadingEdge":["AMOT","WWC3","MOB1A"]} {"pathway":"GO_POSITIVE_REGULATION_OF_GRANULOCYTE_CHEMOTAXIS","pval":0.39418,"padj":0.89503,"ES":0.86265,"NES":1.13117,"nMoreExtreme":24209,"size":19,"leadingEdge":["CD74","EDN1","DYSF","CAMK1D","CCL19","CXCL8","RIPOR2","DAPK2"]} {"pathway":"GO_REGULATION_OF_MUSCLE_ADAPTATION","pval":0.25913,"padj":0.82758,"ES":0.71317,"NES":1.13082,"nMoreExtreme":19242,"size":70,"leadingEdge":["AGT","CAMK2D","KLF4","P2RX4","EDN1","NR4A3","MYH7","PAK1","SMAD3"]} {"pathway":"GO_SALIVA_SECRETION","pval":0.60943,"padj":0.94703,"ES":0.84564,"NES":1.13076,"nMoreExtreme":32707,"size":6,"leadingEdge":["TIFAB","FGF10","NEUROG1"]} {"pathway":"GO_SEQUESTERING_OF_CALCIUM_ION","pval":0.23994,"padj":0.82313,"ES":0.68418,"NES":1.13064,"nMoreExtreme":18964,"size":103,"leadingEdge":["P2RX7","CXCL11","CXCL10","CXCL9","MCOLN2","CAMK2D","SRI","ANK2","LYN","JPH4","SLC8A1","CCR5","PTPRC","TGFB1","CCL19","CCL3","CX3CL1","PLCB1","CLIC2"]} {"pathway":"GO_CALCIUM_ION_TRANSMEMBRANE_IMPORT_INTO_CYTOSOL","pval":0.23994,"padj":0.82313,"ES":0.68418,"NES":1.13064,"nMoreExtreme":18964,"size":103,"leadingEdge":["P2RX7","CXCL11","CXCL10","CXCL9","MCOLN2","CAMK2D","SRI","ANK2","LYN","JPH4","SLC8A1","CCR5","PTPRC","TGFB1","CCL19","CCL3","CX3CL1","PLCB1","CLIC2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS","pval":0.3497,"padj":0.8843,"ES":0.83346,"NES":1.13038,"nMoreExtreme":22146,"size":24,"leadingEdge":["ZC3H12A","CTNS","STAT3","CFLAR","MIR212","FYN"]} {"pathway":"GO_ENDOCRINE_SYSTEM_DEVELOPMENT","pval":0.24883,"padj":0.82387,"ES":0.69528,"NES":1.13018,"nMoreExtreme":19137,"size":88,"leadingEdge":["ONECUT2","HESX1","SIDT2","IL6","FGF10","TBX19","ASCL1","PDGFRA","CDKN1C","GATA3","SMAD3","BAK1","ARID5B","ALDH1A2","TBX1","SOX2","SIX1"]} {"pathway":"GO_VENTRAL_SPINAL_CORD_INTERNEURON_DIFFERENTIATION","pval":0.60188,"padj":0.94684,"ES":0.87555,"NES":1.13008,"nMoreExtreme":33163,"size":8,"leadingEdge":["ASCL1","GLI2"]} {"pathway":"GO_REGULATION_OF_MAPK_CASCADE","pval":0.11042,"padj":0.69745,"ES":0.62172,"NES":1.13006,"nMoreExtreme":10778,"size":594,"leadingEdge":["CD40","GBP1","CD74","P2RX7","LRRK2","NOD2","CEACAM1","CCL13","HGF","BANK1","ATF3","JAK2","RIPK2","CCL7","FAS","ICAM1","KLF4","CCL15","CCL8","SCIMP","ZC3H12A","CYLD","RAPGEF2","BTN2A2","EDN1","SLAMF1","NCF1","NRK","MIR503","IL1RN","GADD45B","GLIPR2","CCL18","CCL5","LYN","DTNBP1","VRK2","GAREM1","IL6","TLR3","FGF10","GADD45G","SEMA7A","NOTCH2","TNF","FLT1","DUSP10","RASGRP1","CCL1","FGD2","PTPRC","CHI3L1","CCL4","FPR2","CCL2","PTPN2","PAK1","SRC","TGFB1","ROBO1","CCL19","PRDX1","PDGFRA","DUSP5","PTPN1","PKHD1","SH3RF1","LPAR1","GAS6","CCL3","CX3CL1","CFLAR","BIRC7"]} {"pathway":"GO_REGULATION_OF_ANATOMICAL_STRUCTURE_SIZE","pval":0.14536,"padj":0.74662,"ES":0.62747,"NES":1.12993,"nMoreExtreme":13807,"size":407,"leadingEdge":["P2RX7","LRRK2","GCH1","CD38","PLEK","ATP13A2","AGT","SLC12A3","SPTBN4","ICAM1","SCIN","NPR1","TMSB10","EDN1","COMP","NRCAM","SOD2","SEMA7A","SLC8A1","SLC12A7","NTN1","CXCL12","ACTR3C","PTAFR","PAK1","GCLC","SEMA4A","CDC42EP2","KCNMA1","GUCY1A1","P2RY2","ACTN2","MAP2","PTGS2","FOXC1","AP1AR","SEMA4D","SPTA1","SLIT2","SCPEP1","TRIM46","NGF","EDNRA","KCNMB1","RUFY3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MONOCYTE_CHEMOTAXIS","pval":0.45742,"padj":0.90517,"ES":0.88425,"NES":1.12975,"nMoreExtreme":27180,"size":15,"leadingEdge":["CXCL10","CCL5","CCL1","CXCL12","FPR2","CCR1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_KIDNEY_DEVELOPMENT","pval":0.29985,"padj":0.85717,"ES":0.77752,"NES":1.12965,"nMoreExtreme":20170,"size":37,"leadingEdge":["AGT","SOX8","TGFB1","CFLAR","GATA3","LIN28A","PDGFB","SIX1"]} {"pathway":"GO_PURINE_CONTAINING_COMPOUND_CATABOLIC_PROCESS","pval":0.29225,"padj":0.85228,"ES":0.76543,"NES":1.12941,"nMoreExtreme":19973,"size":41,"leadingEdge":["PDE4B","ENPP4","ADA2"]} {"pathway":"GO_PLATELET_AGGREGATION","pval":0.28111,"padj":0.84355,"ES":0.7474,"NES":1.12936,"nMoreExtreme":19681,"size":48,"leadingEdge":["CEACAM1","PLEK","TSPAN32","COMP","LYN","P2RY12","GP1BA","PDGFRA","GAS6"]} {"pathway":"GO_MEMBRANE_BIOGENESIS","pval":0.32542,"padj":0.87041,"ES":0.80828,"NES":1.12924,"nMoreExtreme":21117,"size":29,"leadingEdge":["S100A10","FLOT1","PEX3"]} {"pathway":"GO_REGULATION_OF_VIRAL_ENTRY_INTO_HOST_CELL","pval":0.35123,"padj":0.88663,"ES":0.83258,"NES":1.1292,"nMoreExtreme":22243,"size":24,"leadingEdge":["CD74","IFITM2","IFITM1","TRIM31","IFITM3","TRIM21","TRIM25"]} {"pathway":"GO_REGULATION_OF_ER_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT","pval":0.45844,"padj":0.90517,"ES":0.88343,"NES":1.12871,"nMoreExtreme":27241,"size":15,"leadingEdge":["LRRK2","SAR1A"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS","pval":0.03548,"padj":0.48232,"ES":0.61605,"NES":1.12845,"nMoreExtreme":3543,"size":1343,"leadingEdge":["IRF1","IL31RA","PSME2","AIM2","CD40","CD74","P2RX7","SOCS1","LRRK2","GSAP","IL15","NOD2","CCL13","HGF","TNFSF10","PSME1","BANK1","NMI","JAK2","NUB1","AGT","RIPK2","TLR8","CCL7","IL27","FAS","ACSL1","ICAM1","KLF4","BCL2L11","MUC1","CCL15","SAMD4A","FLT3LG","TNFSF18","CD80","SOAT1","PML","FAM20A","RNF19B","CCL8","C3","MEFV","SCIMP","ZC3H12A","RAPGEF2","CASP4","STAP1","ENPP2","RALB","EDN1","VEGFC","SLAMF1","NCF1","NRK","FAM107A","PMAIP1","IL1RN","GADD45B","STAP2","GLIPR2","BCL6","CCL18","CCL5","LYN","IL12A","PYHIN1","TRABD2A","PARP14","TLR7","CSF1","TNFRSF14","TANK","PARP9","AMER1","GAREM1","IRF4","TNFAIP3","EDEM1","RNF144B","BIRC3","CASP10","IL6","TLR3","FGF10","TXN","LTB","GADD45G","SEMA7A","NOTCH2","TNF","EBI3","FLT1","HPN","CD86","RASGRP1","CCL1","FGD2","LCP2","PTPRC","CHI3L1","PTAFR","CCL4","NR1H3","AUTS2","FPR2","CASP5","F3","SOCS3","CCL2","STAT3","NBN","PAK1","GCLC","SRC","TGFB1","ROBO1","CCL19","CDKN1A","AKIRIN2","PDGFRA","CTSC","DUSP5","PTPN1","NFKBIA","SH3RF1","LPAR1","PLGRKT","PTGS2","GAS6","CCL3","CX3CL1","PRELID1","CFLAR","TCIM","GATA3","BIRC7","CASP1","NKX3-1","NFE2L2","SRCIN1","IL33","LIN28A","SEMA4D","HERPUD1","BBC3","PLCB1","PDGFB","SMAD3"]} {"pathway":"GO_TISSUE_MIGRATION","pval":0.18798,"padj":0.78227,"ES":0.64055,"NES":1.12829,"nMoreExtreme":16861,"size":246,"leadingEdge":["CD40","CEACAM1","AMOT","AGT","KLF4","ZC3H12A","P2RX4","ENPP2","EDN1","VEGFC","MIR503","GLIPR2","GLUL","PRKX","ANXA3","FGF10","EGR3","STAT5A","DUSP10","SRC","TGFB1","SEMA4A","ROBO1","CCR6","ADGRB1","PTGS2","HAS2","GATA3","NFE2L2","MIR212","PDGFB","SLIT2"]} {"pathway":"GO_CYTIDINE_TO_URIDINE_EDITING","pval":0.60291,"padj":0.94684,"ES":0.87405,"NES":1.12815,"nMoreExtreme":33220,"size":8,"leadingEdge":["APOBEC3D","APOBEC3A","APOBEC3G","APOBEC3F"]} {"pathway":"GO_CATION_TRANSMEMBRANE_TRANSPORT","pval":0.115,"padj":0.70006,"ES":0.62078,"NES":1.12803,"nMoreExtreme":11217,"size":587,"leadingEdge":["ATP1B2","P2RX7","CXCL11","PDE4B","CXCL10","SLC31A2","CXCL9","GRIN3A","KCNJ10","AGT","STEAP4","SLC12A3","KCNJ2","MCOLN2","CAMK2D","VPS9D1","KCNJ15","SRI","RASGRF1","CTSS","P2RX4","SLC2A6","C15orf48","SLC25A28","ANK2","DYSF","LYN","SLC25A45","KCNE5","ANXA3","RNF207","STAC3","JPH4","SLC8A1","HPN","SCN9A","CCR5","SLC12A7","GEM","PTPRC","SLC25A25","SLC4A10","KCNE1","PSEN2","CACNA1I","P2RY12","TGFB1","KCNMA1","CCL19","SLC22A1","UCP2","ATP6V1A","SLC7A2","CLCN4","HVCN1","ACTN2","GAS6","PARL","CCL3","CX3CL1","RGS9","MIR212","PLCB1","CLIC2","SLC8A2","GLRX","KCNE1B","STOM","SHISA7","S100A1","ARC","SLC31A1","MAPK8IP2","KCNMB1","SLC9A4"]} {"pathway":"GO_REGULATION_OF_AMYLOID_BETA_FORMATION","pval":0.37664,"padj":0.89036,"ES":0.84843,"NES":1.12789,"nMoreExtreme":23440,"size":21,"leadingEdge":["GSAP","HAP1"]} {"pathway":"GO_CELLULAR_HOMEOSTASIS","pval":0.09179,"padj":0.66374,"ES":0.61812,"NES":1.12759,"nMoreExtreme":9060,"size":739,"leadingEdge":["ATP1B2","CD40","P2RX7","LRRK2","CXCL11","CD38","CXCL10","CCL13","ATP13A2","SLC31A2","CXCL9","JAK2","AGT","SLC12A3","CCL7","KCNJ2","MCOLN2","CAMK2D","ICAM1","SIDT2","CCL15","TGM2","PML","SRI","CCL8","CCRL2","P2RX4","RAB20","EDN1","NCF1","SCO2","ANK2","DGAT2","MT2A","SLAMF8","PTGER4","CCL5","LYN","IL6","TXN","MT1M","JPH4","PTGER2","SLC8A1","CUL1","GPR18","F2RL2","MT1E","CCR5","CCL1","SLC12A7","CXCL12","PTPRC","SLC4A10","AUTS2","FPR2","ACKR4","CCL2","GCLC","TGFB1","KCNMA1","CCL19","CCR6","UCP2","PRDX1","MT1H","ATP6V1A","PDGFRA","C19orf12","HVCN1","P2RY2","GRINA","MCL1","PKHD1","LPAR1","NME8","NCF2","GAS6","CCL3","CX3CL1","CKB","MT1G","NFE2L2","LIN28A","HERPUD1","PLCB1","CLIC2","SLC8A2","NADK","SMAD3","RAB38","RAB39A","GLRX","BAK1"]} {"pathway":"GO_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND","pval":0.0418,"padj":0.51963,"ES":0.61561,"NES":1.12744,"nMoreExtreme":4173,"size":1252,"leadingEdge":["IL18BP","IDO1","CD40","P2RX7","SOCS1","CD274","LRRK2","GCH1","CXCL11","CD38","PDCD1LG2","IL15","PDE4B","CXCL10","NOD2","CEACAM1","HGF","SELL","TNFSF10","ACOD1","CXCL9","EGR2","SSTR2","STAT1","GRIN3A","JAK2","AGT","PIM1","RIPK2","CCL7","ACSL1","XRN1","VCAM1","CYP1A1","ICAM1","SIDT2","KLF4","CD80","CSF2RB","SRI","ZC3H12A","JAK3","P2RX4","RAPGEF2","CASP4","CARD17","STAP1","CARD16","IL12RB2","GJD3","GRAMD1B","EDN1","NCF1","IGF2R","CISH","LILRA2","IL1RN","SBNO2","DGAT2","POLB","PTGER4","CMPK2","LITAF","CCL5","LYN","IL12A","GLUL","TICAM2","LTA","NR4A3","PLSCR4","SOD2","TNFAIP3","IL6","FGF10","TXN","NFKB2","TNF","PTGER2","STAT5A","SLC8A1","VGF","DUSP10","CD86","TRIM72","SMPD3","CCR5","NCOA1","ASCL1","CXCL12","CYP27B1","PTAFR","NR1H3","NR4A2","LILRB1","KCNE1","FPR2","SOCS3","CCL2","SH2B2","MAFA","KMO","STAT3","P2RY12","PTPN2","PAK1","GCLC","SRC","TGFB1","KCNMA1","CCL19","CXCL8","CDKN1A","AKIRIN2","UCP2","TXNIP","PRDX1","ATP6V1A","PDGFRA","NAMPT","RRAGC","PTPN1","P2RY2","RHOQ","SORT1","NFKBIA","ACTN2","LPAR1","PTGS2","NME8","GAS6","ASNS","CCL3","IRF5","CX3CL1","GUCY1B1","TRIM25","CFLAR","RGS9","RRAGD","GATA3","AGTRAP","CASP1","NKX3-1","NFE2L2","PPARGC1B","LIN28A"]} {"pathway":"GO_INTERFERON_GAMMA_SECRETION","pval":0.49982,"padj":0.91966,"ES":0.88963,"NES":1.12732,"nMoreExtreme":29109,"size":13,"leadingEdge":["BTN3A2","BTN3A1","ZC3H12A","RASGRP1","LILRB1","GATA3","CD244"]} {"pathway":"GO_RESPONSE_TO_NICOTINE","pval":0.34165,"padj":0.87818,"ES":0.82107,"NES":1.12727,"nMoreExtreme":21859,"size":26,"leadingEdge":["VCAM1","EDN1","TNF","BAD"]} {"pathway":"GO_SODIUM_ION_EXPORT_ACROSS_PLASMA_MEMBRANE","pval":0.61502,"padj":0.9477,"ES":0.86155,"NES":1.12697,"nMoreExtreme":33429,"size":7,"leadingEdge":["ATP1B2","SLC8A1","ATP1B3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MUSCLE_CONTRACTION","pval":0.37809,"padj":0.89036,"ES":0.84768,"NES":1.1269,"nMoreExtreme":23530,"size":21,"leadingEdge":["SRI","ZC3H12A","KCNMA1","GUCY1A1","PTGS2"]} {"pathway":"GO_AMINO_ACID_IMPORT","pval":0.37814,"padj":0.89036,"ES":0.84765,"NES":1.12686,"nMoreExtreme":23533,"size":21,"leadingEdge":["KCNJ10","AGT","SLC7A2"]} {"pathway":"GO_INHIBITORY_SYNAPSE_ASSEMBLY","pval":0.60362,"padj":0.94684,"ES":0.87294,"NES":1.12671,"nMoreExtreme":33259,"size":8,"leadingEdge":["SEMA4A","SEMA4D","GABRG2"]} {"pathway":"GO_ACTIN_FILAMENT_BASED_MOVEMENT","pval":0.24297,"padj":0.82387,"ES":0.67789,"NES":1.1265,"nMoreExtreme":19382,"size":109,"leadingEdge":["PDE4B","KCNJ2","CAMK2D","SRI","ANK2","KCNE5","MYH7","RNF207","DES","KCNE1","MYO1E","ACTN2","KCNE1B"]} {"pathway":"GO_POSITIVE_REGULATION_OF_T_CELL_MEDIATED_CYTOTOXICITY","pval":0.36279,"padj":0.89036,"ES":0.83585,"NES":1.12638,"nMoreExtreme":22825,"size":23,"leadingEdge":["P2RX7","IL12RB1","HLA-F","HLA-B","HLA-E","HLA-A","HLA-C","B2M","HLA-G","IL12A","PTPRC"]} {"pathway":"GO_MHC_CLASS_I_BIOSYNTHETIC_PROCESS","pval":0.61094,"padj":0.94703,"ES":0.84217,"NES":1.12613,"nMoreExtreme":32788,"size":6,"leadingEdge":["CIITA","NLRC5","IFNL1"]} {"pathway":"GO_MYELOID_LEUKOCYTE_MIGRATION","pval":0.21876,"padj":0.80167,"ES":0.65631,"NES":1.12603,"nMoreExtreme":18511,"size":161,"leadingEdge":["CD74","CXCL11","PDE4B","CXCL10","CCL13","CXCL9","CCL7","MCOLN2","CCL15","CCL8","P2RX4","STAP1","EDN1","VEGFC","IL1RN","DYSF","SLAMF8","PTGER4","CCL18","CCL5","LYN","CSF1","IL6","FLT1","CD47","CAMK1D","CCL1","CXCL12","CCL4","FPR2","CCL2","P2RY12","CCL19","CXCL8","RIPOR2","CCL3","CX3CL1","DAPK2","PLCB1","PDGFB","SLIT2","FCER1G"]} {"pathway":"GO_TOXIN_METABOLIC_PROCESS","pval":0.46208,"padj":0.90517,"ES":0.88094,"NES":1.12553,"nMoreExtreme":27457,"size":15,"leadingEdge":["CYP1A1","SQOR","NFE2L2","CBSL"]} {"pathway":"GO_REGULATION_OF_RESPONSE_TO_WOUNDING","pval":0.23757,"padj":0.82177,"ES":0.67048,"NES":1.12525,"nMoreExtreme":19274,"size":122,"leadingEdge":["SERPING1","CEACAM1","PLEK","KREMEN1","KLF4","SCARF1","ENPP4","EDN1","LYN","TNFAIP3","DUSP10","F3","CDKN1A","GP1BA","PDGFRA","RGMA","NFE2L2","PDGFB","SMAD3","MYOZ1","FCER1G","TLR4"]} {"pathway":"GO_DNA_DEMETHYLATION","pval":0.37987,"padj":0.89036,"ES":0.84634,"NES":1.12511,"nMoreExtreme":23641,"size":21,"leadingEdge":["APOBEC3D","APOBEC3A","APOBEC3G","APOBEC3F","OTUD4","GATA3"]} {"pathway":"GO_RECEPTOR_GUANYLYL_CYCLASE_SIGNALING_PATHWAY","pval":0.59022,"padj":0.94238,"ES":0.81758,"NES":1.12465,"nMoreExtreme":31230,"size":5,"leadingEdge":["NPR1","GUCA1B"]} {"pathway":"GO_ALPHA_BETA_T_CELL_LINEAGE_COMMITMENT","pval":0.42904,"padj":0.89886,"ES":0.86942,"NES":1.12436,"nMoreExtreme":25926,"size":17,"leadingEdge":["IL12RB1","TBX21","SLAMF6","IRF4","IL6","STAT3"]} {"pathway":"GO_FOAM_CELL_DIFFERENTIATION","pval":0.346,"padj":0.88254,"ES":0.81887,"NES":1.12425,"nMoreExtreme":22137,"size":26,"leadingEdge":["STAT1","AGT","SOAT1","CSF1","NR1H3","TGFB1","NFKBIA"]} {"pathway":"GO_CHEMOKINE_BIOSYNTHETIC_PROCESS","pval":0.50336,"padj":0.91988,"ES":0.88692,"NES":1.12389,"nMoreExtreme":29315,"size":13,"leadingEdge":["IL6","TLR3","TNF","TICAM1"]} {"pathway":"GO_RESPONSE_TO_MUSCLE_STRETCH","pval":0.484,"padj":0.91689,"ES":0.88268,"NES":1.1233,"nMoreExtreme":28488,"size":14,"leadingEdge":["EDN1","SLC8A1","NFKBIA","SLC9A1"]} {"pathway":"GO_ACTIN_FILAMENT_DEPOLYMERIZATION","pval":0.29105,"padj":0.85125,"ES":0.74319,"NES":1.123,"nMoreExtreme":20377,"size":48,"leadingEdge":["PLEK","SPTBN4","SCIN","ACTN2","SPTA1"]} {"pathway":"GO_GLYCOSPHINGOLIPID_BIOSYNTHETIC_PROCESS","pval":0.41749,"padj":0.89503,"ES":0.86206,"NES":1.1227,"nMoreExtreme":25400,"size":18,"leadingEdge":["B4GALT5","ST3GAL5","ST8SIA5"]} {"pathway":"GO_RESPONSE_TO_MINERALOCORTICOID","pval":0.38345,"padj":0.89036,"ES":0.84441,"NES":1.12254,"nMoreExtreme":23864,"size":21,"leadingEdge":["EDN1","SRC","CDKN1A","CYBA"]} {"pathway":"GO_VASCULAR_SMOOTH_MUSCLE_CELL_DEVELOPMENT","pval":0.60576,"padj":0.94703,"ES":0.86968,"NES":1.12251,"nMoreExtreme":33377,"size":8,"leadingEdge":["COMP","VEGFA"]} {"pathway":"GO_REGULATION_OF_SODIUM_ION_TRANSPORT","pval":0.27497,"padj":0.83769,"ES":0.71148,"NES":1.12236,"nMoreExtreme":20281,"size":67,"leadingEdge":["ATP1B2","P2RX7","CAMK2D","SPTBN4","P2RX4","SLC8A1","TGFB1","GLRX","STOM","SIK1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT","pval":0.31253,"padj":0.86489,"ES":0.77576,"NES":1.12234,"nMoreExtreme":20935,"size":36,"leadingEdge":["LRRK2","TXN","KCNE1","SP100"]} {"pathway":"GO_HYALURONAN_BIOSYNTHETIC_PROCESS","pval":0.50473,"padj":0.91988,"ES":0.88566,"NES":1.12229,"nMoreExtreme":29395,"size":13,"leadingEdge":["SMPD3","TGFB1","HAS2","PDGFB"]} {"pathway":"GO_REGULATION_OF_PRODUCTION_OF_SMALL_RNA_INVOLVED_IN_GENE_SILENCING_BY_RNA","pval":0.40491,"padj":0.89503,"ES":0.85583,"NES":1.12222,"nMoreExtreme":24868,"size":19,"leadingEdge":["ZC3H12A","TGFB1","LIN28A","ZMPSTE24"]} {"pathway":"GO_REGULATION_OF_VASCULOGENESIS","pval":0.54986,"padj":0.93134,"ES":0.88613,"NES":1.12212,"nMoreExtreme":31396,"size":11,"leadingEdge":["CEACAM1","RAPGEF2","RAP1A"]} {"pathway":"GO_BIOLOGICAL_ADHESION","pval":0.06148,"padj":0.59072,"ES":0.61298,"NES":1.12202,"nMoreExtreme":6129,"size":1111,"leadingEdge":["IRF1","ATP1B2","HLA-DPA1","IDO1","HLA-DMB","GBP1","CD74","SOCS1","HAPLN3","CD274","IL12RB1","SLAMF7","LYPD5","PDCD1LG2","IL15","IL32","LAG3","HLA-DPB1","TBX21","NOD2","CEACAM1","ADGRE5","PLEK","SELL","HLA-E","CHRD","CTLA4","JAK2","ITGA7","RIPK2","ONECUT2","TNFSF13B","GLDN","VCAM1","ICAM1","MDGA1","KLF4","SCARF1","BCL2L11","MUC1","TGM2","RSU1","TNFSF18","CD80","PDCD1","TSPAN32","PML","ZC3H12A","JAK3","CYLD","LGALS3BP","ICAM2","BTN2A2","SLAMF1","MIR503","FAM107A","IL1RN","S100A10","COMP","DYSF","HLA-G","MPZL2","BCL6","CCL5","LYN","IL12A","TNFAIP6","CSF1","NR4A3","TNFRSF14","SSPN","IL7","NRCAM","PTPRU","PRKX","CD83","RND1","CD72","ANXA3","ICAM4","IL6","LILRB4","EGR3","TNF","EBI3","CD226","DUSP10","CD86","CD47","RASGRP1","FARP2","ITGAL","NTN1","CXCL12","PTPRC","PTAFR","CCL4","LILRB1","FPR2","CCL2","P2RY12","PTPN2","ITGB7","PAK1","PODXL","RUNX1","SRC","TGFB1","NTNG2","ICOS","CCDC88B","ROBO1","IL2RA","CCL19","CXCL8","GP1BA","PDGFRA","ACTN2","ADGRB1","PKHD1","GPM6B","RIPOR2","ASTN1","HAS2","GAS6","CX3CL1","AP1AR"]} {"pathway":"GO_CD8_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION","pval":0.40517,"padj":0.89503,"ES":0.85564,"NES":1.12198,"nMoreExtreme":24884,"size":19,"leadingEdge":["IRF1","SOCS1","CD274","HLA-E","GPR18","LILRB1","RUNX1","SH3RF1"]} {"pathway":"GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION_BY_CALCIUM_ION_SIGNALING","pval":0.39435,"padj":0.89503,"ES":0.84973,"NES":1.12182,"nMoreExtreme":24376,"size":20,"leadingEdge":["CAMK2D","ANK2","SLC8A1","CLIC2","HDAC4"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR","pval":0.38461,"padj":0.89083,"ES":0.84372,"NES":1.12163,"nMoreExtreme":23936,"size":21,"leadingEdge":["CD74","MUC1","KDM1A"]} {"pathway":"GO_B_CELL_HOMEOSTASIS","pval":0.34561,"padj":0.88254,"ES":0.81171,"NES":1.12122,"nMoreExtreme":22222,"size":27,"leadingEdge":["CD74","TNFSF13B","BCL2L11","LYN","TNFAIP3","SH2B2","BAK1"]} {"pathway":"GO_SUPEROXIDE_METABOLIC_PROCESS","pval":0.28807,"padj":0.84886,"ES":0.73411,"NES":1.12104,"nMoreExtreme":20393,"size":52,"leadingEdge":["GCH1","AGT","EDN1","NCF1","NCF1B","NCF1C","SOD2","TNF","FPR2","TGFB1","PRDX1","NCF2","NFE2L2"]} {"pathway":"GO_REGULATION_OF_ACTIN_FILAMENT_BASED_PROCESS","pval":0.18005,"padj":0.77529,"ES":0.62712,"NES":1.12093,"nMoreExtreme":16771,"size":333,"leadingEdge":["PDE4B","PLEK","KCNJ2","CAMK2D","SPTBN4","ICAM1","SRI","STAP1","SCIN","TMSB10","EDN1","FAM107A","RHOBTB3","ANK2","S100A10","PTGER4","PPM1E","RND1","RNF207","CD47","CXCL12","ACTR3C","RHOH","PAK1","TGFB1","ARHGAP17","CDC42EP2","PDGFRA","RHOQ","ACTN2","LPAR1","GPM6B","CX3CL1","AP1AR","SMAD3","SPTA1","SLIT2"]} {"pathway":"GO_NITRIC_OXIDE_SYNTHASE_BIOSYNTHETIC_PROCESS","pval":0.46679,"padj":0.90738,"ES":0.87732,"NES":1.1209,"nMoreExtreme":27737,"size":15,"leadingEdge":["LRRK2","NOD2","STAT1","JAK2","EDN1","CCL2","NAMPT","TLR4"]} {"pathway":"GO_BONE_TRABECULA_MORPHOGENESIS","pval":0.52773,"padj":0.92669,"ES":0.88496,"NES":1.12065,"nMoreExtreme":30440,"size":12,"leadingEdge":["SBNO2","PPARGC1B","SEMA4D","MMP2"]} {"pathway":"GO_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY","pval":0.17573,"padj":0.77529,"ES":0.62536,"NES":1.12064,"nMoreExtreme":16489,"size":354,"leadingEdge":["CD74","LRRK2","HGF","TNFSF10","ATF3","JAK2","AGT","BCL2A1","FAS","ICAM1","BCL2L11","MUC1","PML","CYLD","PMAIP1","IL7","SOD2","TNFAIP3","FGF10","TNF","RBCK1","CXCL12","PTPRC","NR4A2","PTPN2","GCLC","SRC","CTSC","PTPN1","IFI6","GRINA","MCL1","SH3RF1","PLEKHF1","PTGS2","CX3CL1","PRELID1","CFLAR","NKX3-1","NFE2L2","HERPUD1","DAPK2","BBC3","SMAD3","TRAF1","BAK1","IL1A"]} {"pathway":"GO_TRANSMEMBRANE_TRANSPORT","pval":0.06324,"padj":0.59455,"ES":0.61213,"NES":1.12048,"nMoreExtreme":6305,"size":1118,"leadingEdge":["SLC6A12","ATP1B2","APOL1","TAP2","PSME2","TAP1","P2RX7","CXCL11","PSMB9","PDE4B","CXCL10","ATP13A2","PSME1","SLC31A2","CXCL9","SLC37A1","GRIN3A","KCNJ10","PSMB10","AGT","ABCC11","STEAP4","SLC12A3","ANO4","PSMB8","KCNJ2","MCOLN2","CAMK2D","VPS9D1","KCNJ15","TMEM144","FLVCR2","SRI","C3","RASGRF1","ABCB1","CTSS","P2RX4","SLC2A6","GJD3","TMEM109","EDN1","C15orf48","SLC25A28","ANK2","SLC18A1","CLIC5","DYSF","CTNS","LYN","SLC25A45","NR4A3","KCNE5","SLC2A13","ANXA3","SLCO4A1","RNF207","SLC49A3","SLC51A","STAC3","RSC1A1","JPH4","TNF","PSMA4","SLC8A1","PSMA2","HPN","SLC25A22","SCN9A","AZIN2","CCR5","SLC12A7","SLC26A11","GEM","PTPRC","SLC25A25","SLC4A10","PTAFR","KCNE1","PSEN2","CACNA1I","P2RY12","TGFB1","KCNMA1","CCL19","SLC22A1","PSMA5","UCP2","ATP6V1A","SLC7A2","CLCN4","HVCN1","RHOQ","SORT1","ACTN2","GABRR2","MCL1","SLC29A3","GAS6","PARL","ABCC2","CCL3","MFSD2A","CX3CL1","RGS9","TMEM63C","SLC44A2","ERLIN1","NFE2L2","ADAMTS8","MIR212","PLCB1","CLIC2","SLC8A2"]} {"pathway":"GO_PROTEIN_LINEAR_POLYUBIQUITINATION","pval":0.59109,"padj":0.9431,"ES":0.81434,"NES":1.1202,"nMoreExtreme":31276,"size":5,"leadingEdge":["RBCK1","RNF31"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_6_SECRETION","pval":0.59321,"padj":0.94378,"ES":0.87682,"NES":1.11996,"nMoreExtreme":33150,"size":9,"leadingEdge":["BANK1","ZC3H12A","GAS6"]} {"pathway":"GO_NUCLEOSIDE_BISPHOSPHATE_CATABOLIC_PROCESS","pval":0.54621,"padj":0.93112,"ES":0.78637,"NES":1.11983,"nMoreExtreme":28427,"size":4,"leadingEdge":["ACAT1","ACOT7","ABCD1","MLYCD"]} {"pathway":"GO_GAMMA_AMINOBUTYRIC_ACID_SECRETION","pval":0.61828,"padj":0.94878,"ES":0.85571,"NES":1.11934,"nMoreExtreme":33606,"size":7,"leadingEdge":["P2RX7","TRPC4"]} {"pathway":"GO_FLUID_TRANSPORT","pval":0.50765,"padj":0.92244,"ES":0.8833,"NES":1.1193,"nMoreExtreme":29565,"size":13,"leadingEdge":["EDN1","HAS2","AQP9"]} {"pathway":"GO_MYELOID_CELL_DIFFERENTIATION","pval":0.18478,"padj":0.77988,"ES":0.62645,"NES":1.1192,"nMoreExtreme":17184,"size":329,"leadingEdge":["IL31RA","UBD","CD74","SNX10","CEACAM1","BATF2","STAT1","JAK2","BATF3","LILRB3","PML","B2M","JAK3","SCIN","IRF7","SBNO2","RELB","BCL6","LYN","CSF1","NR4A3","PRKX","IRF4","TLR3","LILRB4","NOTCH2","TNF","MOV10","FARP2","LILRB1","STAT3","PTPN2","RUNX1","SRC","TGFB1","OCSTAMP","CCL19","C1QC","GP1BA","CDKN1C","NFKBIA","ISG15","CCL3","GATA3","MT1G","PPARGC1B"]} {"pathway":"GO_ALPHA_BETA_T_CELL_PROLIFERATION","pval":0.33929,"padj":0.87818,"ES":0.80105,"NES":1.11914,"nMoreExtreme":22017,"size":29,"leadingEdge":["IRF1","CD274","IL15","HLA-E","RIPK2","TNFRSF14","EBI3","PTPRC","SH3RF1"]} {"pathway":"GO_PHOSPHOLIPID_METABOLIC_PROCESS","pval":0.21426,"padj":0.7999,"ES":0.6396,"NES":1.11904,"nMoreExtreme":18903,"size":217,"leadingEdge":["PLAAT4","SOCS1","NOD2","PLEK","PLAAT3","KLF4","PLA1A","CISH","LYN","TMEM150A","PLA2G4C","LPCAT2","FLT1","PLA2G4A","SMPD3","FPR2","SOCS3","P2RY12","SRC","TGFB1","AGPAT3","CCL19","PDGFRA","PLPP1","PLCB1","PDGFB","PIGY","AGAP2","PLPPR4","LPGAT1","MTMR8"]} {"pathway":"GO_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS","pval":0.26764,"padj":0.83635,"ES":0.68981,"NES":1.11877,"nMoreExtreme":20525,"size":86,"leadingEdge":["GCH1","JAK2","AGT","CYP1A1","ICAM1","KLF4","ZC3H12A","P2RX4","EDN1","CTNS","TNF","CD47","STAT3","SLC7A2","ADGRB1","PTGS2","CFLAR","MIR212","SMAD3","TLR4","ASS1"]} {"pathway":"GO_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE","pval":0.22972,"padj":0.81508,"ES":0.64976,"NES":1.11859,"nMoreExtreme":19586,"size":169,"leadingEdge":["LRRK2","HGF","AGT","TGM2","PML","EDN1","CSF1","CTSZ","FGF10","TNF","SOX8","SOCS3","PAK1","SRC","TGFB1","NKX3-1","SLIT2","HOXD11","EDNRA","MET","PROX1","WNT1","HNF1B","SEMA3E","RERE","LAMA1","SIX1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_RIG_I_SIGNALING_PATHWAY","pval":0.60814,"padj":0.94703,"ES":0.86655,"NES":1.11846,"nMoreExtreme":33508,"size":8,"leadingEdge":["DHX58","UFD1"]} {"pathway":"GO_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS","pval":0.19291,"padj":0.79001,"ES":0.62851,"NES":1.11812,"nMoreExtreme":17736,"size":300,"leadingEdge":["LRRK2","CD38","PDE4B","DPYS","GIMAP7","TYMP","APOBEC3D","ENPP4","APOBEC3A","APOBEC3G","ACOT4","SULT1C2","GTPBP1","DGAT2","CTNS","CMPK2","MYH7","APOBEC3F","SLC25A25","KMO","ATP6V1A","ADA2","RHOQ","ACSM5","ACPP","AK4","NADK","GLRX"]} {"pathway":"GO_RESPONSE_TO_KETONE","pval":0.23638,"padj":0.8216,"ES":0.65382,"NES":1.11804,"nMoreExtreme":19881,"size":154,"leadingEdge":["CD38","ACOD1","XRN1","ICAM1","KLF4","EDN1","PTGER4","PTGER2","NCOA1","PTAFR","NR1H3","SRC","TGFB1","CCL19","CDKN1A","TXNIP","CFLAR","NKX3-1","SLIT2"]} {"pathway":"GO_AMINO_ACID_TRANSMEMBRANE_TRANSPORT","pval":0.28803,"padj":0.84886,"ES":0.72321,"NES":1.11778,"nMoreExtreme":20664,"size":57,"leadingEdge":["SLC6A12","KCNJ10","AGT","SLC25A22","SLC7A2"]} {"pathway":"GO_EPITHELIAL_CELL_APOPTOTIC_PROCESS","pval":0.27315,"padj":0.83739,"ES":0.69519,"NES":1.11774,"nMoreExtreme":20680,"size":79,"leadingEdge":["CD40","JAK2","ICAM1","HLA-G","TNFAIP3","IL6","TNF","CCL2","ANGPTL4","SORT1","GAS6","CFLAR","GATA3","NFE2L2","ZFP36"]} {"pathway":"GO_RESPONSE_TO_STEROID_HORMONE","pval":0.19554,"padj":0.79001,"ES":0.62908,"NES":1.11753,"nMoreExtreme":17916,"size":291,"leadingEdge":["CD38","ACOD1","SSTR2","PADI2","JAK2","ICAM1","PAQR8","BCL2L11","EDN1","FAM107A","IL1RN","EPHX1","NR4A3","PTPRU","ANXA3","IL6","TNF","PTGER2","HNF4G","NCOA1","PTAFR","NR1H3","NR4A2","PAK1","RUNX1","SRC","TGFB1","CDKN1A","TXNIP","CREBRF","PTGS2","PLPP1","CFLAR","NKX3-1","PPARGC1B","ZFP36","SLIT2","RORB","NCOA4","ESRRB","NPC1","ASS1"]} {"pathway":"GO_RESPONSE_TO_INTERLEUKIN_13","pval":0.54667,"padj":0.93112,"ES":0.78469,"NES":1.11743,"nMoreExtreme":28451,"size":4,"leadingEdge":["CD300LF","IL13RA1"]} {"pathway":"GO_RESPONSE_TO_MUSCLE_INACTIVITY","pval":0.61932,"padj":0.94878,"ES":0.85385,"NES":1.11691,"nMoreExtreme":33663,"size":7,"leadingEdge":["HDAC4","PKM"]} {"pathway":"GO_CARDIAC_MUSCLE_CELL_CONTRACTION","pval":0.28981,"padj":0.85125,"ES":0.72247,"NES":1.11664,"nMoreExtreme":20792,"size":57,"leadingEdge":["PDE4B","KCNJ2","CAMK2D","SRI","ANK2","KCNE5","RNF207","KCNE1","KCNE1B"]} {"pathway":"GO_MODIFICATION_OF_MORPHOLOGY_OR_PHYSIOLOGY_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION","pval":0.26866,"padj":0.83693,"ES":0.68356,"NES":1.11651,"nMoreExtreme":20823,"size":92,"leadingEdge":["IFI27","BCL2L11","CCL8","ZC3H12A","KPNA5","CCL5","HPN","SERPINB9","CCL4","TGFB1","CCL3","SMAD3","STOM","GTF2B"]} {"pathway":"GO_ORGANOPHOSPHATE_METABOLIC_PROCESS","pval":0.16482,"padj":0.76986,"ES":0.61843,"NES":1.11649,"nMoreExtreme":15765,"size":443,"leadingEdge":["PLAAT4","SOCS1","LRRK2","CD38","NOD2","PLEK","PLAAT3","GIMAP7","KLF4","ACOT4","PLA1A","SULT1C2","GTPBP1","CISH","DGAT2","CTNS","CMPK2","LYN","TMEM150A","MYH7","PLA2G4C","LPCAT2","FLT1","PFKP","PLA2G4A","SMPD3","SLC25A25","FPR2","SOCS3","KMO","P2RY12","SRC","TGFB1","AGPAT3","CCL19","ATP6V1A","PDGFRA","RHOQ","GPD2","ACSM5","PLPP1","ACPP","AK4","PLCB1","NADK","PDGFB"]} {"pathway":"GO_PYRIMIDINE_RIBONUCLEOSIDE_CATABOLIC_PROCESS","pval":0.59543,"padj":0.94465,"ES":0.87405,"NES":1.11643,"nMoreExtreme":33274,"size":9,"leadingEdge":["APOBEC3D","APOBEC3A","APOBEC3G","APOBEC3F"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS","pval":0.57621,"padj":0.94161,"ES":0.87938,"NES":1.1164,"nMoreExtreme":32524,"size":10,"leadingEdge":["TIFAB","NR1H3","NEUROG1"]} {"pathway":"GO_DIVALENT_INORGANIC_CATION_TRANSPORT","pval":0.18474,"padj":0.77988,"ES":0.6228,"NES":1.11623,"nMoreExtreme":17341,"size":356,"leadingEdge":["P2RX7","CXCL11","PDE4B","CXCL10","CXCL9","GRIN3A","AGT","KCNJ2","MCOLN2","CAMK2D","ICAM1","PML","SRI","CCL8","P2RX4","LILRA2","ANK2","DYSF","CCL5","LYN","STAC3","JPH4","SLC8A1","TCN2","CCR5","CXCL12","GEM","CYP27B1","PTPRC","BSPRY","SLC25A25","CCL4","LILRB1","PSEN2","CCL2","CACNA1I","P2RY12","TGFB1","CCL19","PTGS2","GAS6","PARL","CCL3","CX3CL1","RGS9","SPINK1","PLCB1","CLIC2","SLC8A2","PDGFB"]} {"pathway":"GO_REGULATION_OF_ANIMAL_ORGAN_FORMATION","pval":0.34384,"padj":0.88094,"ES":0.79882,"NES":1.11603,"nMoreExtreme":22312,"size":29,"leadingEdge":["PIM1","FGF10","ROBO1","SIX1","HOXA11"]} {"pathway":"GO_CELLULAR_MONOVALENT_INORGANIC_CATION_HOMEOSTASIS","pval":0.27431,"padj":0.83769,"ES":0.69024,"NES":1.11554,"nMoreExtreme":20922,"size":83,"leadingEdge":["ATP1B2","LRRK2","AGT","KCNJ2","RAB20","SLAMF8","SLC8A1","SLC4A10","KCNMA1","ATP6V1A","RAB38","RAB39A"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CATALYTIC_ACTIVITY","pval":0.13761,"padj":0.73301,"ES":0.61342,"NES":1.11551,"nMoreExtreme":13453,"size":606,"leadingEdge":["C4A","SOCS1","LRRK2","C4B","SERPING1","LAMP3","CEACAM1","AMOT","HGF","LMTK2","AGT","PZP","KLF4","C3","CARD17","CARD16","DTX3L","MVP","GADD45B","PPM1E","LYN","DTNBP1","PARP3","PARP9","IL7","TNFAIP3","ANXA3","BIRC3","TNF","P2RY13","SERPINB9","DUSP10","CYP27B1","PTPRC","RHOH","SOCS3","PTPN2","ANGPTL4","SRC","A2M","CDKN1A","SNX16","TXNIP","ADAR","DUSP5","CDKN1C","UBE2Z","PTPN1","SORT1","MAP2","IFI6","SH3RF1","PTGS2","ELFN1","GAS6","CFLAR","BIRC7","SRCIN1","MIR212","SEMA4D","SERPINB1","SPINK1","HERPUD1","HMSD","ZFP36","SLIT2","MYOZ1","NGF","TNFAIP8"]} {"pathway":"GO_REGULATION_OF_SMALL_MOLECULE_METABOLIC_PROCESS","pval":0.20344,"padj":0.79608,"ES":0.62927,"NES":1.1155,"nMoreExtreme":18540,"size":278,"leadingEdge":["PSME2","PSMB9","CEACAM1","PLEK","PSME1","PSMB10","PSMB8","PMAIP1","TTC39B","DGAT2","NR4A3","TNF","PSMA4","PSMA2","CYP27B1","PTAFR","NR1H3","PTPN2","SRC","PSMA5","PTGS2","ERLIN1","LMF1","SIK1","ESRRB","INSIG2","CPT1A","CD244","LPGAT1","PROX1"]} {"pathway":"GO_CELL_PROLIFERATION_INVOLVED_IN_KIDNEY_DEVELOPMENT","pval":0.42625,"padj":0.89843,"ES":0.85634,"NES":1.11526,"nMoreExtreme":25933,"size":18,"leadingEdge":["STAT1","CFLAR","GATA3","LIN28A","PDGFB"]} {"pathway":"GO_REGULATION_OF_ANATOMICAL_STRUCTURE_MORPHOGENESIS","pval":0.09585,"padj":0.66591,"ES":0.61022,"NES":1.11522,"nMoreExtreme":9514,"size":895,"leadingEdge":["PSME2","CD40","GBP1","LRRK2","PSMB9","CXCL10","CEACAM1","CCL13","AMOT","HGF","PSME1","CXCL9","STAT1","PSMB10","AGT","PIM1","ITGA7","TNFSF13B","STAT2","CCL7","PSMB8","ICAM1","KLF4","FLT3LG","PML","C3","S100A13","ZC3H12A","RAPGEF2","NPR1","ENPP2","EDN1","VEGFC","MIR503","RHOBTB3","IL1RN","S100A10","HLA-G","FMNL2","BCL6","GLUL","CSF1","NRCAM","TNFAIP3","RND1","ANXA3","RNF207","IL6","TLR3","FGF10","PLEKHO1","SEMA7A","TNF","SOX8","PSMA4","FLT1","PSMA2","HPN","ADM2","MOV10","FGD2","NTN1","CXCL12","CHI3L1","RHOH","F3","CCL2","STAT3","PAK1","ANGPTL4","TGIF2","RUNX1","SRC","TGFB1","SEMA4A","CDC42EP2","OCSTAMP","ROBO1","CXCL8","PSMA5","RHOQ","MAP2","ADGRB1","LPAR1","PTGS2","RIPOR2","HAS2","CCL3","CX3CL1","FOXC1","AP1AR","CFLAR","GATA3","NFE2L2","SRCIN1","MIR212","SEMA4D","CD53","ERAP1","FGD6","SYT17","CDC42SE2","SPTA1","SLIT2","IL1A","DDHD1","TRIM46","NGF","PPP1R16B","S100A1","FLOT1","ARC"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SECRETION","pval":0.51182,"padj":0.92419,"ES":0.87997,"NES":1.11507,"nMoreExtreme":29808,"size":13,"leadingEdge":["LRRK2","IFIH1","LILRA2","DDX58","LILRA5","ORM1"]} {"pathway":"GO_REGULATION_OF_ANION_TRANSMEMBRANE_TRANSPORT","pval":0.3854,"padj":0.89163,"ES":0.83255,"NES":1.11463,"nMoreExtreme":24114,"size":22,"leadingEdge":["AGT","ABCB1","PTAFR","ANO9"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MORPHOGENESIS_OF_AN_EPITHELIUM","pval":0.51244,"padj":0.92419,"ES":0.87952,"NES":1.11451,"nMoreExtreme":29844,"size":13,"leadingEdge":["STAT1","TNF","GATA3","CLASP1"]} {"pathway":"GO_NOTCH_SIGNALING_PATHWAY","pval":0.24047,"padj":0.82313,"ES":0.65031,"NES":1.11437,"nMoreExtreme":20309,"size":158,"leadingEdge":["NOD2","STAT1","BHLHE41","DTX3L","BCL6","CHAC1","FGF10","NOTCH2","ASCL1","PSEN2","STAT3","TGFB1","ROBO1","IL2RA","NFKBIA","FOXC1","TCIM","MIR212","SLC35C2","WNT1","HNF1B","MAML2","GDPD5"]} {"pathway":"GO_MEMBRANE_LIPID_BIOSYNTHETIC_PROCESS","pval":0.25702,"padj":0.82758,"ES":0.66444,"NES":1.11419,"nMoreExtreme":20816,"size":121,"leadingEdge":["P2RX7","B4GALT5","TNF","SMPD3","ST3GAL5","ELOVL7","PLPP1","PIGY","KDSR"]} {"pathway":"GO_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS","pval":0.17179,"padj":0.77295,"ES":0.61743,"NES":1.11397,"nMoreExtreme":16402,"size":434,"leadingEdge":["ISG20","ADAR","PRPF3","ERI1","C9orf72","BMT2"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND","pval":0.09723,"padj":0.66591,"ES":0.60945,"NES":1.11391,"nMoreExtreme":9654,"size":904,"leadingEdge":["IL18BP","CD40","P2RX7","SOCS1","CD274","LRRK2","GCH1","CXCL11","PDCD1LG2","IL15","PDE4B","CXCL10","NOD2","CEACAM1","HGF","ACOD1","CXCL9","SSTR2","STAT1","JAK2","AGT","PIM1","RIPK2","CCL7","XRN1","VCAM1","ICAM1","SIDT2","KLF4","CD80","SRI","ZC3H12A","JAK3","P2RX4","RAPGEF2","CASP4","CARD17","STAP1","CARD16","GRAMD1B","EDN1","NCF1","CISH","LILRA2","IL1RN","SBNO2","DGAT2","PTGER4","CMPK2","LITAF","CCL5","LYN","TICAM2","NR4A3","PLSCR4","SOD2","TNFAIP3","IL6","TXN","TNF","PTGER2","STAT5A","SLC8A1","CD86","TRIM72","SMPD3","CCR5","CYP27B1","PTAFR","NR1H3","NR4A2","LILRB1","KCNE1","FPR2","SOCS3","CCL2","SH2B2","KMO","STAT3","P2RY12","PTPN2","PAK1","GCLC","SRC","TGFB1","CXCL8","UCP2","PRDX1","ATP6V1A","PDGFRA","NAMPT","RRAGC","PTPN1","P2RY2","RHOQ","NFKBIA","ACTN2","LPAR1","PTGS2","NME8","GAS6","CCL3","CX3CL1","GUCY1B1","CFLAR","RRAGD","AGTRAP","CASP1","NFE2L2","PPARGC1B","LIN28A","PLCB1","NADK","PDGFB"]} {"pathway":"GO_NUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS","pval":0.29343,"padj":0.85379,"ES":0.71862,"NES":1.11367,"nMoreExtreme":21133,"size":58,"leadingEdge":["ACOT4","SULT1C2","DGAT2","ACSM5","ACSM3"]} {"pathway":"GO_CHEMICAL_HOMEOSTASIS","pval":0.10531,"padj":0.68115,"ES":0.60944,"NES":1.11341,"nMoreExtreme":10443,"size":849,"leadingEdge":["ATP1B2","CD40","P2RX7","LRRK2","SNX10","CXCL11","CD38","CXCL10","CCL13","ATP13A2","SLC31A2","CXCL9","STAT1","KCNJ10","JAK2","SUCNR1","AGT","STEAP4","SLC12A3","CCL7","KCNJ2","MCOLN2","CAMK2D","ICAM1","SIDT2","CCL15","TGM2","SOAT1","PML","FAM20A","SRI","B2M","CCL8","CCRL2","P2RX4","RAB20","NPR1","GRAMD1B","EDN1","SCO2","SLC25A28","ANK2","TTC39B","DGAT2","MT2A","SLAMF8","PTGER4","DYNLT1","CCL5","LYN","SOD2","MT1M","JPH4","PTGER2","SLC8A1","VGF","CUL1","GPR18","F2RL2","MT1E","CCR5","CCL1","SLC12A7","CXCL12","CYP27B1","PTPRC","SLC4A10","LIPG","NR1H3","FPR2","ACKR4","TMTC2","STAT3","PTPN2","ANGPTL4","GCLC","SRC","TGFB1","KCNMA1","CCL19","CCR6","UCP2","MT1H","ATP6V1A","PDGFRA","C19orf12","P2RY2","IFI6","GRINA","PKHD1","LPAR1","HAS2","GAS6","CCL3","CX3CL1","CKB","MT1G","LIN28A","HERPUD1","PLCB1","CLIC2","SLC8A2","NADK","SMAD3","RAB38"]} {"pathway":"GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS","pval":0.25422,"padj":0.82744,"ES":0.66019,"NES":1.11313,"nMoreExtreme":20804,"size":129,"leadingEdge":["ISG20","XRN1","ZC3H12A","PIWIL4","HELZ2","MOV10","ERI1","TSEN34"]} {"pathway":"GO_OUTER_DYNEIN_ARM_ASSEMBLY","pval":0.59761,"padj":0.94558,"ES":0.87143,"NES":1.11308,"nMoreExtreme":33396,"size":9,"leadingEdge":["DNAAF1","LRRC61","DNAH5"]} {"pathway":"GO_ANTERIOR_POSTERIOR_AXON_GUIDANCE","pval":0.54742,"padj":0.93115,"ES":0.78162,"NES":1.11306,"nMoreExtreme":28490,"size":4,"leadingEdge":["UNC5C","NTN1"]} {"pathway":"GO_NEURON_PROJECTION_REGENERATION","pval":0.30491,"padj":0.86182,"ES":0.73433,"NES":1.11263,"nMoreExtreme":21394,"size":49,"leadingEdge":["HGF","KREMEN1","JAK2","KLF4","SCARF1","RGMA"]} {"pathway":"GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE_BY_P53_CLASS_MEDIATOR","pval":0.44273,"padj":0.90221,"ES":0.8603,"NES":1.11256,"nMoreExtreme":26753,"size":17,"leadingEdge":["CD74","MUC1","KDM1A"]} {"pathway":"GO_POSITIVE_REGULATION_OF_AMINO_ACID_TRANSPORT","pval":0.55841,"padj":0.93517,"ES":0.87811,"NES":1.11196,"nMoreExtreme":31884,"size":11,"leadingEdge":["P2RX7","AGT","KMO","ADORA2A"]} {"pathway":"GO_CHONDROCYTE_DEVELOPMENT_INVOLVED_IN_ENDOCHONDRAL_BONE_MORPHOGENESIS","pval":0.43057,"padj":0.89981,"ES":0.8538,"NES":1.11196,"nMoreExtreme":26196,"size":18,"leadingEdge":["SMPD3","COCH","COL27A1"]} {"pathway":"GO_NK_T_CELL_ACTIVATION","pval":0.55855,"padj":0.93517,"ES":0.87795,"NES":1.11176,"nMoreExtreme":31892,"size":11,"leadingEdge":["IL15","IL12A","ELF4"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR","pval":0.34134,"padj":0.87818,"ES":0.78751,"NES":1.11166,"nMoreExtreme":22345,"size":31,"leadingEdge":["CD74","MUC1","KDM1A"]} {"pathway":"GO_REGULATION_OF_CELL_DEATH","pval":0.05986,"padj":0.58367,"ES":0.60682,"NES":1.11153,"nMoreExtreme":5978,"size":1344,"leadingEdge":["IL31RA","IDO1","UBD","CD40","CD74","P2RX7","BCL2L14","CD274","LRRK2","CD38","LAMP3","CXCL10","NOD2","HLA-F","HGF","TNFSF10","ATP13A2","ATF3","STAT1","CTLA4","HCAR2","JAK2","AGT","PIM1","BCL2A1","RIPK2","FAS","CAMK2D","ICAM1","KLF4","BCL2L11","MUC1","TGM2","FLT3LG","TNFSF18","AIFM2","PDCD1","PML","IFIT3","ZC3H12A","JAK3","CYLD","RAPGEF2","IFIT2","CASP4","CARD17","SCIN","ATF5","IRF7","CARD16","TMEM109","EDN1","IGF2R","PMAIP1","GADD45B","COMP","HLA-G","GIMAP8","BCL6","CCL5","LYN","IL12A","CSF1","LTA","NR4A3","C3orf38","IL7","SOD2","TNFAIP3","ARHGEF3","RNF144B","BIRC3","MYD88","CASP10","CTSZ","IL6","TLR3","FGF10","TXN","EGR3","GADD45G","NOTCH2","CHST11","TNF","SOX8","HPN","SERPINB9","RBCK1","CAMK1D","CCR5","FGD2","NCOA1","ASCL1","UNC5C","CXCL12","PTPRC","NR4A2","LILRB1","PSEN2","CASP5","F3","SOCS3","CCL2","KMO","STAT3","PTPN2","MNDA","ANGPTL4","NUAK2","GCLC","SRC","TGFB1","KCNMA1","ROBO1","BCL2L15","CCL19","CDKN1A","UCP2","TXNIP","CTSC","UBE2Z","PTPN1","SORT1","NFKBIA","ACTN2","IFI6","GRINA","MCL1","LIG4","PKHD1","SH3RF1","LPAR1","PLEKHF1","PTGS2","ADAMTS20","GAS6","ASNS","CCL3","IRF5","CX3CL1","FOXC1","PRELID1","CFLAR","TCIM","GATA3","BIRC7","CASP1","NKX3-1","NFE2L2","TNFRSF6B","SEMA4D","HERPUD1","DAPK2","BBC3","RILPL1","SMAD3","TRAF1","ZFP36","SLIT2","BAK1","IL1A","NUPR1","SIK1","FCER1G","PNMA2","NGF","TNFAIP8"]} {"pathway":"GO_NEUROTRANSMITTER_CATABOLIC_PROCESS","pval":0.49563,"padj":0.91907,"ES":0.8734,"NES":1.11149,"nMoreExtreme":29172,"size":14,"leadingEdge":["COLQ","CHDH"]} {"pathway":"GO_RESPONSE_TO_MANGANESE_ION","pval":0.46029,"padj":0.90517,"ES":0.86501,"NES":1.11125,"nMoreExtreme":27572,"size":16,"leadingEdge":["LRRK2","ATP13A2","PTGS2"]} {"pathway":"GO_REGULATION_OF_CELLULAR_COMPONENT_MOVEMENT","pval":0.11601,"padj":0.70006,"ES":0.6084,"NES":1.11113,"nMoreExtreme":11491,"size":811,"leadingEdge":["CD40","CD74","CD274","PDE4B","CXCL10","CEACAM1","AMOT","HGF","CHRD","PADI2","JAK2","AGT","ONECUT2","CCL7","KCNJ2","CAMK2D","ICAM1","KLF4","DNAAF1","IFITM1","TNFSF18","SRI","CCL8","ZC3H12A","P2RX4","RAPGEF2","STAP1","ENPP2","TMSB10","EDN1","VEGFC","MIR503","FAM107A","ANK2","DYSF","GLIPR2","SLAMF8","PTGER4","BCL6","CCL5","LYN","IL12A","GLUL","TNFAIP6","CSF1","NR4A3","TNFRSF14","SOD2","PTPRU","PRKX","RND1","ANXA3","CXCL16","RNF207","NRG4","IL6","FGF10","SEMA7A","TNF","STAT5A","FLT1","SLC8A1","DUSP10","MIIP","GPR18","CAMK1D","SMPD3","CCL1","UNC5C","NTN1","CXCL12","PTPRC","PTAFR","DDX58","CCL4","FPR2","F3","CCL2","STAT3","P2RY12","PAK1","NRG2","PODXL","SRC","TGFB1","SEMA4A","ROBO1","CCL19","CCR6","CXCL8","PDGFRA","MAP2","ADGRB1","PKHD1","LPAR1","PTGS2","RIPOR2","HAS2","GAS6","CCL3","CX3CL1","AP1AR","GATA3","NFE2L2","SRCIN1","IL33","MIR212","SEMA4D","DAPK2","PLCB1","PDGFB","SMAD3"]} {"pathway":"GO_INORGANIC_ION_TRANSMEMBRANE_TRANSPORT","pval":0.15295,"padj":0.75292,"ES":0.61172,"NES":1.11093,"nMoreExtreme":14890,"size":570,"leadingEdge":["ATP1B2","APOL1","P2RX7","CXCL11","PDE4B","CXCL10","SLC31A2","CXCL9","SLC37A1","GRIN3A","KCNJ10","STEAP4","SLC12A3","KCNJ2","MCOLN2","CAMK2D","VPS9D1","KCNJ15","SRI","P2RX4","SLC2A6","C15orf48","SLC25A28","ANK2","CLIC5","DYSF","LYN","KCNE5","RNF207","STAC3","JPH4","SLC8A1","HPN","SCN9A","CCR5","SLC12A7","SLC26A11","GEM","PTPRC","SLC25A25","SLC4A10","PTAFR","KCNE1","PSEN2","CACNA1I","P2RY12","TGFB1","KCNMA1","CCL19","UCP2","ATP6V1A","CLCN4","HVCN1","ACTN2","GABRR2","GAS6","PARL","CCL3","CX3CL1","ADAMTS8","MIR212","PLCB1","CLIC2","SLC8A2","GLRX","KCNE1B","STOM"]} {"pathway":"GO_POSITIVE_REGULATION_OF_HEART_RATE","pval":0.49637,"padj":0.91907,"ES":0.87276,"NES":1.11068,"nMoreExtreme":29216,"size":14,"leadingEdge":["GCH1","EDN1","KCNQ1"]} {"pathway":"GO_REGULATION_OF_SKELETAL_MUSCLE_CONTRACTION","pval":0.59926,"padj":0.94564,"ES":0.86939,"NES":1.11048,"nMoreExtreme":33488,"size":9,"leadingEdge":["KCNJ2","MYH7","SLC8A3"]} {"pathway":"GO_ACTIVATION_OF_JANUS_KINASE_ACTIVITY","pval":0.53697,"padj":0.92816,"ES":0.87682,"NES":1.11034,"nMoreExtreme":30973,"size":12,"leadingEdge":["SOCS1","JAK2","AGT","CCL5"]} {"pathway":"GO_PHOSPHATIDYLSERINE_ACYL_CHAIN_REMODELING","pval":0.55991,"padj":0.93517,"ES":0.87638,"NES":1.10977,"nMoreExtreme":31970,"size":11,"leadingEdge":["PLAAT3","PLA1A","PLA2G4A","OSBPL5"]} {"pathway":"GO_REGULATION_OF_PROTEIN_KINASE_C_SIGNALING","pval":0.51723,"padj":0.9251,"ES":0.87555,"NES":1.10947,"nMoreExtreme":30123,"size":13,"leadingEdge":["CD40","AKAP12","SEZ6L","FLT4"]} {"pathway":"GO_NEUROINFLAMMATORY_RESPONSE","pval":0.30565,"padj":0.86234,"ES":0.72634,"NES":1.10918,"nMoreExtreme":21638,"size":52,"leadingEdge":["LRRK2","TLR8","STAP1","TLR7","IL6","TLR3","TNF","PTPRC","FPR2","NAMPT","CCL3","CX3CL1","IL33"]} {"pathway":"GO_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT","pval":0.22949,"padj":0.81508,"ES":0.63181,"NES":1.10901,"nMoreExtreme":20414,"size":230,"leadingEdge":["P2RX7","CXCL11","PDE4B","CXCL10","CXCL9","GRIN3A","MCOLN2","CAMK2D","SRI","P2RX4","ANK2","DYSF","LYN","STAC3","JPH4","SLC8A1","CCR5","GEM","PTPRC","SLC25A25","PSEN2","CACNA1I","P2RY12","TGFB1","CCL19","GAS6","PARL","CCL3","CX3CL1","PLCB1","CLIC2","SLC8A2"]} {"pathway":"GO_CARDIAC_ATRIUM_DEVELOPMENT","pval":0.36191,"padj":0.89036,"ES":0.80286,"NES":1.10899,"nMoreExtreme":23270,"size":27,"leadingEdge":["ANK2","NOTCH2","HEG1","PROX1"]} {"pathway":"GO_AXONEMAL_DYNEIN_COMPLEX_ASSEMBLY","pval":0.49845,"padj":0.91907,"ES":0.87142,"NES":1.10897,"nMoreExtreme":29338,"size":14,"leadingEdge":["DNAAF1","LRRC61","DNAH5"]} {"pathway":"GO_RESPONSE_TO_DRUG","pval":0.12891,"padj":0.72213,"ES":0.6077,"NES":1.1088,"nMoreExtreme":12730,"size":749,"leadingEdge":["IL18BP","AIM2","CD40","P2RX7","LRRK2","CD38","PDE4B","NOD2","HGF","SELL","ACOD1","STAT1","GRIN3A","KCNJ10","AGT","RIPK2","CCL7","ACSL1","XRN1","VCAM1","CYP1A1","ICAM1","KLF4","B2M","ZC3H12A","ABCB1","P2RX4","EDN1","VEGFC","NUCB1","SLC18A1","S100A10","MT2A","CD69","SLAMF8","POLB","PPM1E","LYN","DTNBP1","LTA","NR4A3","KYNU","TNFAIP3","IL6","TLR3","TXN","TNF","PTGER2","SLC8A1","TCN2","SLC25A22","SMPD3","NCOA1","ASCL1","CXCL12","SLC25A25","PTAFR","NR1H3","NR4A2","STAT3","P2RY12","GCLC","SRC","TGFB1","KCNMA1","SYT5","CCL19","SLC22A1","CDKN1A","TXNIP","SLC7A2","P2RY2","NFKBIA","PTGS2","AMN","GAS6","ASNS","IRF5","GUCY1B1","CFLAR","RGS9","GATA3","NKX3-1","NFE2L2","AK4","PLCB1","PDGFB","NFKBIE","SYT17","SLIT2","BAK1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_GLUTAMATE_SECRETION","pval":0.62258,"padj":0.94878,"ES":0.84762,"NES":1.10875,"nMoreExtreme":33840,"size":7,"leadingEdge":["P2RX7","KMO","ADORA2A"]} {"pathway":"GO_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY","pval":0.05097,"padj":0.55514,"ES":0.60489,"NES":1.10843,"nMoreExtreme":5094,"size":1546,"leadingEdge":["TIFA","GBP5","HLA-DMA","HLA-DMB","AIM2","CD40","GBP1","CD74","P2RX7","LRRK2","HLA-DRA","GCH1","HLA-DRB1","NOD2","PSTPIP2","PLEK","KCTD14","MSRB1","JAK2","ERC2","STEAP4","DPYS","TAPBP","FAS","KCNJ2","MCOLN2","CAMK2D","SPTBN4","ICAM1","BCL2L11","DNAAF1","TGM2","GSDMD","SOAT1","TRIM22","LRRC61","PRRT2","PML","POMP","MEFV","ZC3H12A","CYLD","P2RX4","SCIN","RALB","TMSB10","FAM107A","PMAIP1","SCO2","S100A10","HLA-G","PTGER4","CCL5","GLUL","TRABD2A","CADPS2","NPM2","SOD2","AMER1","TNFAIP3","BIRC3","CTSZ","DECR1","TNF","FCHO1","CUL1","HOPX","TRIM72","RASGRP1","SMPD3","PDE4DIP","FARP2","CXCL12","TCF7L1","MX1","ACTR3C","P2RY12","PAK1","TRIM9","ANGPTL4","SRC","TGFB1","CDC42EP2","SLC22A1","UVRAG","TRIM21","CTSC","ADAR","IKBKE","ACTN2","MAP2","PRPF3","TPPP","IKZF4","CX3CL1","ACPP","AP1AR"]} {"pathway":"GO_MYELOID_DENDRITIC_CELL_ACTIVATION","pval":0.36664,"padj":0.89036,"ES":0.80733,"NES":1.10841,"nMoreExtreme":23458,"size":26,"leadingEdge":["UBD","BATF2","BATF3","FLT3LG","TSPAN32","SLAMF1","RELB","IRF4","CLEC4D","TGFB1"]} {"pathway":"GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE_BY_P53_CLASS_MEDIATOR","pval":0.31996,"padj":0.86901,"ES":0.74839,"NES":1.10832,"nMoreExtreme":21940,"size":42,"leadingEdge":["CD74","MUC1","PML","TMEM109","NUPR1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INTERFERON_BETA_PRODUCTION","pval":0.51864,"padj":0.92533,"ES":0.87447,"NES":1.10811,"nMoreExtreme":30205,"size":13,"leadingEdge":["NMI","RELB","LILRB1"]} {"pathway":"GO_NEGATIVE_REGULATION_BY_HOST_OF_VIRAL_TRANSCRIPTION","pval":0.56161,"padj":0.93517,"ES":0.87486,"NES":1.10785,"nMoreExtreme":32067,"size":11,"leadingEdge":["CCL5","CCL4","CCL3","REST"]} {"pathway":"GO_VESICLE_DOCKING_INVOLVED_IN_EXOCYTOSIS","pval":0.3228,"padj":0.86974,"ES":0.75068,"NES":1.10765,"nMoreExtreme":22061,"size":41,"leadingEdge":["PLEK","RALB","STX3"]} {"pathway":"GO_THYROID_HORMONE_MEDIATED_SIGNALING_PATHWAY","pval":0.59383,"padj":0.94378,"ES":0.80507,"NES":1.10744,"nMoreExtreme":31421,"size":5,"leadingEdge":["NCOA1","MED1"]} {"pathway":"GO_B_CELL_PROLIFERATION","pval":0.30107,"padj":0.85813,"ES":0.70685,"NES":1.10637,"nMoreExtreme":21989,"size":63,"leadingEdge":["CD40","CD74","CD38","CTLA4","TNFSF13B","BCL6","LYN","IL7","PTPRC","MNDA"]} {"pathway":"GO_REGULATION_OF_T_CELL_TOLERANCE_INDUCTION","pval":0.61416,"padj":0.94703,"ES":0.85713,"NES":1.10631,"nMoreExtreme":33840,"size":8,"leadingEdge":["IDO1","HLA-G","IL2RA","LILRB2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE","pval":0.2588,"padj":0.82758,"ES":0.64758,"NES":1.10617,"nMoreExtreme":21709,"size":152,"leadingEdge":["CD74","NOD2","CCL13","RIPK2","CCL7","ICAM1","CCL15","CCL8","SCIMP","RAPGEF2","SLAMF1","GLIPR2","CCL18","CCL5","GAREM1","FGF10","SEMA7A","NOTCH2","TNF","FLT1","RASGRP1","CCL1","PTPRC","CHI3L1","CCL4","FPR2","CCL2","SRC","TGFB1","CCL19","PDGFRA","GAS6","CCL3","CX3CL1","CFLAR"]} {"pathway":"GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_CHEMOTAXIS","pval":0.48335,"padj":0.91689,"ES":0.86552,"NES":1.10582,"nMoreExtreme":28721,"size":15,"leadingEdge":["CCL7","CCL5","CCL4","CCL3","WNK1"]} {"pathway":"GO_RESPONSE_TO_PROGESTERONE","pval":0.3316,"padj":0.87332,"ES":0.75778,"NES":1.10564,"nMoreExtreme":22421,"size":38,"leadingEdge":["CD38","ACOD1","PTGER2","NCOA1","NR1H3","SRC","TGFB1","TXNIP","PTN"]} {"pathway":"GO_HOMEOSTASIS_OF_NUMBER_OF_CELLS","pval":0.24112,"padj":0.82358,"ES":0.63275,"NES":1.10554,"nMoreExtreme":21204,"size":212,"leadingEdge":["CD74","P2RX7","PDE4B","STAT1","HCAR2","JAK2","TNFSF13B","BCL2L11","FLT3LG","B2M","JAK3","CYLD","PMAIP1","POLB","BCL6","LYN","CSF1","IL7","TNFAIP3","IL6","SH2B2","STAT3","PTPN2","TGFB1","IL2RA","PRDX1","ISG15","GATA3","SPTA1","ZFP36","BAK1","FCER1G"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_DEPOLYMERIZATION","pval":0.45127,"padj":0.90517,"ES":0.85483,"NES":1.10549,"nMoreExtreme":27269,"size":17,"leadingEdge":["PLEK","ACTN2","SPAST"]} {"pathway":"GO_APOPTOTIC_SIGNALING_PATHWAY","pval":0.17434,"padj":0.77529,"ES":0.60973,"NES":1.10545,"nMoreExtreme":16886,"size":524,"leadingEdge":["CD74","P2RX7","LRRK2","CD38","HGF","TNFSF10","ATF3","JAK2","AGT","BCL2A1","IFI27","FAS","ICAM1","BCL2L11","MUC1","PML","CYLD","P2RX4","CASP4","TMEM109","PMAIP1","POLB","IL12A","CHAC1","TICAM2","IL7","SOD2","TNFAIP3","CD70","CASP10","TLR3","FGF10","TNF","RBCK1","CUL1","CXCL12","PTPRC","NR4A2","CASP5","NBN","PTPN2","GCLC","SRC","TGFB1","CDKN1A","CTSC","IKBKE","PTPN1","SORT1","IFI6","GRINA","MCL1","SH3RF1","PLEKHF1","PTGS2","CX3CL1","PRELID1","CFLAR","CASP1","NKX3-1","NFE2L2","IL33","HERPUD1","DAPK2","BBC3","SMAD3","TRAF1","BAK1","IL1A","NUPR1","NGF","HIC1","TLR4","FNIP2","MAPK8IP2"]} {"pathway":"GO_INTERLEUKIN_10_PRODUCTION","pval":0.32501,"padj":0.87041,"ES":0.74642,"NES":1.1054,"nMoreExtreme":22286,"size":42,"leadingEdge":["IDO1","CD274","PDCD1LG2","NOD2","HGF","JAK3","CD83","IRF4","CD47","LILRB1","FCER1G","LILRA5","TLR4"]} {"pathway":"GO_REGULATION_OF_PROTEIN_KINASE_C_ACTIVITY","pval":0.59438,"padj":0.94445,"ES":0.80351,"NES":1.10529,"nMoreExtreme":31450,"size":5,"leadingEdge":["TCIM","WNT5A"]} {"pathway":"GO_ORGANIC_ACID_METABOLIC_PROCESS","pval":0.14766,"padj":0.7508,"ES":0.6065,"NES":1.1052,"nMoreExtreme":14531,"size":681,"leadingEdge":["IDO1","PSME2","CD74","PSMB9","CEACAM1","PSME1","ACOD1","IDO2","PSMB10","DPYS","IL4I1","ACSL1","PSMB8","CYP1A1","HSD3B7","OSBPL6","C3","ACOT4","MTHFD2","PPA1","EDN1","DHRS9","DGAT2","CTNS","GGT5","GLUL","NR4A3","KYNU","SLC27A3","PLA2G4C","SDSL","DECR1","CBR1","STAT5A","PSMA4","PSMA2","CH25H","PLA2G4A","ACSL5","NR1H3","ELOVL7","KMO","GCLC","LDHAL6B","ACSS1","HPD","PSMA5","MMAA","NAGK","SLC7A2","PTGS2","ACSM5","ASNS","CES1","ERLIN1","GLS","ACBD5","SCPEP1","SEPHS2","INSIG2","CPT1A","NPC1","SDHB","ASS1","MTHFR","CBSL","ALDH1A2","SDS","LPGAT1","PROX1"]} {"pathway":"GO_ENDOPLASMIC_RETICULUM_CALCIUM_ION_HOMEOSTASIS","pval":0.39716,"padj":0.89503,"ES":0.82551,"NES":1.1052,"nMoreExtreme":24850,"size":22,"leadingEdge":["CAMK2D","TGM2","PML","GRINA","HERPUD1","BAK1"]} {"pathway":"GO_RESPONSE_TO_COPPER_ION","pval":0.33606,"padj":0.87575,"ES":0.7639,"NES":1.10518,"nMoreExtreme":22511,"size":36,"leadingEdge":["CYP1A1","ICAM1","S100A13","MT2A","MT1M","MT1E","MT1H","MT1G","NFE2L2","IL1A"]} {"pathway":"GO_POSITIVE_REGULATION_OF_B_CELL_PROLIFERATION","pval":0.34752,"padj":0.88271,"ES":0.77856,"NES":1.10497,"nMoreExtreme":22853,"size":32,"leadingEdge":["CD40","CD74","CD38","TNFSF13B","BCL6","IL7","PTPRC"]} {"pathway":"GO_CHLORIDE_TRANSMEMBRANE_TRANSPORT","pval":0.31421,"padj":0.86489,"ES":0.72501,"NES":1.10474,"nMoreExtreme":22197,"size":51,"leadingEdge":["APOL1","SLC12A3","CLIC5","SLC12A7","CLCN4","GABRR2","CLIC2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PROTEOLYSIS_INVOLVED_IN_CELLULAR_PROTEIN_CATABOLIC_PROCESS","pval":0.30485,"padj":0.86182,"ES":0.70711,"NES":1.10462,"nMoreExtreme":22202,"size":62,"leadingEdge":["LAMP3","PML","WNT1","PANO1"]} {"pathway":"GO_MONOCYTE_CHEMOTACTIC_PROTEIN_1_PRODUCTION","pval":0.56413,"padj":0.93517,"ES":0.87217,"NES":1.10444,"nMoreExtreme":32211,"size":11,"leadingEdge":["MCOLN2","GSTP1"]} {"pathway":"GO_RESPONSE_TO_THYROID_HORMONE","pval":0.41639,"padj":0.89503,"ES":0.83599,"NES":1.10368,"nMoreExtreme":25738,"size":20,"leadingEdge":["CTSS","CTSL","HPN","GCLC","SIX1"]} {"pathway":"GO_T_HELPER_2_CELL_DIFFERENTIATION","pval":0.50426,"padj":0.91988,"ES":0.86714,"NES":1.10352,"nMoreExtreme":29680,"size":14,"leadingEdge":["BCL6","CD86","GATA3","HLX","PRKCZ"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MAP_KINASE_ACTIVITY","pval":0.30544,"padj":0.86234,"ES":0.70341,"NES":1.10315,"nMoreExtreme":22367,"size":64,"leadingEdge":["LYN","DUSP10","DUSP5","PTPN1","DUSP2"]} {"pathway":"GO_INTRACELLULAR_PROTEIN_TRANSPORT","pval":0.10259,"padj":0.67367,"ES":0.60275,"NES":1.10315,"nMoreExtreme":10222,"size":1064,"leadingEdge":["CD74","LRRK2","STX11","ATP13A2","EGR2","AGT","IFI27","RTP4","PML","ZC3H12A","ACOT4","RAB20","USP6NL","NCF1","NUCB1","GSTK1","ZDHHC19","DYNLT1","KPNA5","TICAM2","EDEM1","TXN","ZDHHC18","RAB24","ZDHHC11B","ATG3","KCNE1","STAT3","PAK1","TGFB1","TBC1D2B","SNX16","AKAP12","TXNIP","PTPN1","PTGS2","GAS6","PARL","SNX8","HERPUD1","RILPL1","NAPA","SMAD3","RAB38","STX3","RAB39A","STX17","STOM","PRR5L","NCOA4","ARC","ZDHHC23","GCC2","XPO6","RUFY3","RAB2B"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_B_CELL_ACTIVATION","pval":0.3738,"padj":0.89036,"ES":0.80345,"NES":1.10309,"nMoreExtreme":23916,"size":26,"leadingEdge":["BANK1","CTLA4","BCL6","LYN","PARP3","TNFAIP3","MNDA"]} {"pathway":"GO_MULTICELLULAR_ORGANISMAL_RESPONSE_TO_STRESS","pval":0.3214,"padj":0.86901,"ES":0.73202,"NES":1.10296,"nMoreExtreme":22432,"size":47,"leadingEdge":["IDO1","GCH1","P2RX4","SCN9A","NR4A2","MAPK8IP2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_BIOSYNTHETIC_PROCESS","pval":0.56567,"padj":0.93517,"ES":0.87072,"NES":1.1026,"nMoreExtreme":32299,"size":11,"leadingEdge":["LRRK2","NOD2","STAT1","JAK2","CCL2","NAMPT","TLR4"]} {"pathway":"GO_SPINAL_CORD_MOTOR_NEURON_CELL_FATE_SPECIFICATION","pval":0.61843,"padj":0.94878,"ES":0.8242,"NES":1.1021,"nMoreExtreme":33190,"size":6,"leadingEdge":["ISL2","GLI2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY","pval":0.25279,"padj":0.82744,"ES":0.63284,"NES":1.102,"nMoreExtreme":22056,"size":200,"leadingEdge":["CD74","LRRK2","HGF","TNFSF10","BCL2A1","FAS","ICAM1","MUC1","IL7","SOD2","TNFAIP3","FGF10","TNF","CXCL12","NR4A2","GCLC","SRC","PTPN1","IFI6","GRINA","MCL1","SH3RF1","PTGS2","CX3CL1","PRELID1","CFLAR","NFE2L2","HERPUD1","IL1A"]} {"pathway":"GO_MUSCLE_ATROPHY","pval":0.62547,"padj":0.94878,"ES":0.84208,"NES":1.10151,"nMoreExtreme":33997,"size":7,"leadingEdge":["IL15","CFLAR"]} {"pathway":"GO_POSITIVE_REGULATION_OF_T_HELPER_CELL_DIFFERENTIATION","pval":0.41923,"padj":0.89569,"ES":0.8343,"NES":1.10145,"nMoreExtreme":25914,"size":20,"leadingEdge":["IL12RB1","RIPK2","CD80","CD86","CCL19","HLX"]} {"pathway":"GO_GANGLIOSIDE_BIOSYNTHETIC_PROCESS","pval":0.60493,"padj":0.94687,"ES":0.86208,"NES":1.10114,"nMoreExtreme":33805,"size":9,"leadingEdge":["B4GALT5","ST3GAL5","ST8SIA4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_LEUKOCYTE_ADHESION_TO_VASCULAR_ENDOTHELIAL_CELL","pval":0.56692,"padj":0.93607,"ES":0.86947,"NES":1.10102,"nMoreExtreme":32370,"size":11,"leadingEdge":["ICAM1","TNF","PTAFR","RHOA"]} {"pathway":"GO_MOVEMENT_IN_ENVIRONMENT_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION","pval":0.34661,"padj":0.88258,"ES":0.76798,"NES":1.10099,"nMoreExtreme":23009,"size":34,"leadingEdge":["PML","TRIM31","CHMP4C","TRIM21","TRIM25"]} {"pathway":"GO_REGULATION_OF_EXTRACELLULAR_MATRIX_CONSTITUENT_SECRETION","pval":0.61878,"padj":0.94878,"ES":0.82332,"NES":1.10092,"nMoreExtreme":33209,"size":6,"leadingEdge":["AGT","TNFRSF1B"]} {"pathway":"GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION_BY_REGULATION_OF_THE_RELEASE_OF_SEQUESTERED_CALCIUM_ION","pval":0.48885,"padj":0.91689,"ES":0.86162,"NES":1.10084,"nMoreExtreme":29048,"size":15,"leadingEdge":["CAMK2D","ANK2","SLC8A1","CLIC2"]} {"pathway":"GO_MITOCHONDRIAL_GENE_EXPRESSION","pval":0.26678,"padj":0.83635,"ES":0.64266,"NES":1.10083,"nMoreExtreme":22514,"size":157,"leadingEdge":["PPARGC1B","ELAC2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_HORMONE_METABOLIC_PROCESS","pval":0.61683,"padj":0.94878,"ES":0.85283,"NES":1.10076,"nMoreExtreme":33987,"size":8,"leadingEdge":["CYP27B1","DKK3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_COMPLEMENT_ACTIVATION","pval":0.62598,"padj":0.94878,"ES":0.84133,"NES":1.10053,"nMoreExtreme":34025,"size":7,"leadingEdge":["SERPING1","A2M","CD59"]} {"pathway":"GO_RESPONSE_TO_PURINE_CONTAINING_COMPOUND","pval":0.2833,"padj":0.84565,"ES":0.65956,"NES":1.10026,"nMoreExtreme":22750,"size":114,"leadingEdge":["P2RX7","SELL","STAT1","XRN1","P2RX4","RAPGEF2","SLC8A1","VGF","PTAFR","KCNE1","P2RY12","P2RY2","PTGS2","PPARGC1B"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MORPHOGENESIS_OF_AN_EPITHELIUM","pval":0.3607,"padj":0.89036,"ES":0.78325,"NES":1.10008,"nMoreExtreme":23513,"size":30,"leadingEdge":["AGT","SOX8","TGFB1","GATA3","SIX1"]} {"pathway":"GO_LIPID_METABOLIC_PROCESS","pval":0.12401,"padj":0.71286,"ES":0.60142,"NES":1.09977,"nMoreExtreme":12329,"size":949,"leadingEdge":["APOL4","APOL1","PLAAT4","P2RX7","SOCS1","APOL2","GK","GOLM1","NOD2","CEACAM1","PLEK","ACOD1","AGT","PLAAT3","ACSL1","CYP1A1","HSD3B7","OSBPL6","KLF4","SOAT1","C3","ACOT4","PLA1A","HSD11B1","ALAS1","LACTB","ENPP2","DHRS9","CISH","IL1RN","TTC39B","DGAT2","SDC3","NAAA","GGT5","LYN","NR4A3","TMEM150A","SLC27A3","B4GALT5","PLA2G4C","DECR1","TNF","CBR1","LPCAT2","FLT1","DGKG","CH25H","PLA2G4A","HELZ2","SMPD3","NCOA1","ACSL5","CYP27B1","LIPG","ST3GAL5","NR1H3","FPR2","ELOVL7","SOCS3","P2RY12","ANGPTL4","SRC","TGFB1","AGPAT3","CCL19","PDGFRA","MMAA","GM2A","PTGS2","PLPP1","CES1"]} {"pathway":"GO_ION_TRANSMEMBRANE_TRANSPORT","pval":0.14657,"padj":0.75017,"ES":0.60226,"NES":1.09954,"nMoreExtreme":14504,"size":784,"leadingEdge":["SLC6A12","ATP1B2","APOL1","P2RX7","CXCL11","PDE4B","CXCL10","ATP13A2","SLC31A2","CXCL9","SLC37A1","GRIN3A","KCNJ10","AGT","STEAP4","SLC12A3","ANO4","KCNJ2","MCOLN2","CAMK2D","VPS9D1","KCNJ15","SRI","RASGRF1","ABCB1","CTSS","P2RX4","SLC2A6","GJD3","TMEM109","C15orf48","SLC25A28","ANK2","CLIC5","DYSF","LYN","SLC25A45","KCNE5","ANXA3","RNF207","STAC3","JPH4","SLC8A1","HPN","SLC25A22","SCN9A","CCR5","SLC12A7","SLC26A11","GEM","PTPRC","SLC25A25","SLC4A10","PTAFR","KCNE1","PSEN2","CACNA1I","P2RY12","TGFB1","KCNMA1","CCL19","SLC22A1","UCP2","ATP6V1A","SLC7A2","CLCN4","HVCN1","ACTN2","GABRR2","GAS6","PARL","CCL3","CX3CL1","RGS9","TMEM63C","ADAMTS8","MIR212","PLCB1","CLIC2","SLC8A2","GLRX","KCNE1B","BAK1","STOM","SHISA7","SLC25A30","S100A1","ARC","SLC35C2","SLC31A1","MAPK8IP2","CPT1A","KCNMB1","SLC9A4"]} {"pathway":"GO_LYMPHOCYTE_HOMEOSTASIS","pval":0.31832,"padj":0.86774,"ES":0.71625,"NES":1.09952,"nMoreExtreme":22658,"size":54,"leadingEdge":["CD74","P2RX7","TNFSF13B","BCL2L11","JAK3","PMAIP1","LYN","TNFAIP3","SH2B2","TGFB1","IL2RA","SPTA1","BAK1"]} {"pathway":"GO_SPERMATOGENESIS_EXCHANGE_OF_CHROMOSOMAL_PROTEINS","pval":0.41442,"padj":0.89503,"ES":0.73714,"NES":1.09949,"nMoreExtreme":20825,"size":2,"leadingEdge":["PSME4","RNF8"]} {"pathway":"GO_PEPTIDE_BIOSYNTHETIC_PROCESS","pval":0.17779,"padj":0.77529,"ES":0.60488,"NES":1.09925,"nMoreExtreme":17345,"size":590,"leadingEdge":["BANK1","XRN1","SAMD4A","ZC3H12A","PPA1","GTPBP1","CNDP2","PIWIL4","MIR503","GGT5","CCL5","CHAC1","IL6","TNF","MOV10","PTAFR","STAT3","TRIM71","GCLC","NFE2L2","LIN28A","MIR212","ZFP36"]} {"pathway":"GO_SPERM_MOTILITY","pval":0.3343,"padj":0.87575,"ES":0.74218,"NES":1.09912,"nMoreExtreme":22923,"size":42,"leadingEdge":["CACNA1I","CCR6","NME8","GAS8","SLC22A16"]} {"pathway":"GO_CILIUM_MOVEMENT","pval":0.34553,"padj":0.88254,"ES":0.75949,"NES":1.0988,"nMoreExtreme":23146,"size":36,"leadingEdge":["DNAAF1","MAATS1","GAS8","DNAH5"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_VITAMIN","pval":0.38029,"padj":0.89036,"ES":0.8001,"NES":1.09848,"nMoreExtreme":24331,"size":26,"leadingEdge":["IL15","PIM1","CYP27B1","GAS6","PTN"]} {"pathway":"GO_APOPTOTIC_PROCESS","pval":0.0686,"padj":0.61251,"ES":0.59927,"NES":1.09814,"nMoreExtreme":6856,"size":1574,"leadingEdge":["IRF1","IL31RA","IDO1","UBD","AIM2","CD40","CD74","P2RX7","BCL2L14","CD274","LRRK2","CD38","LAMP3","CXCL10","NOD2","HGF","KREMEN1","TNFSF10","ATF3","STAT1","CTLA4","HCAR2","JAK2","AGT","PIM1","BCL2A1","IFI27","RIPK2","FAS","CAMK2D","ICAM1","KLF4","BCL2L11","MUC1","TGM2","FLT3LG","TNFSF18","XAF1","AIFM2","PDCD1","PML","IFIT3","ZC3H12A","JAK3","CYLD","P2RX4","RAPGEF2","IFIT2","CASP4","CARD17","DRAM1","SCIN","ATF5","IRF7","CARD16","TRIM69","CASP7","TMEM109","RALB","EDN1","NCF1","IGF2R","PMAIP1","GADD45B","COMP","HLA-G","POLB","XKR6","GIMAP8","BCL6","CCL5","LYN","IL12A","CHAC1","TICAM2","LTA","NR4A3","C3orf38","IL7","CTSL","SOD2","PLSCR1","TNFAIP3","ARHGEF3","RNF144B","CD70","BIRC3","MYD88","CASP10","CTSZ","IL6","TLR3","FGF10","EGR3","GADD45G","NOTCH2","CHST11","TNF","SOX8","HPN","SERPINB9","RBCK1","CUL1","CAMK1D","CCR5","FGD2","NCOA1","ASCL1","UNC5C","NTN1","XKR8","CXCL12","PTPRC","CHI3L1","MX1","ATG3","NR4A2","LILRB1","PSEN2","CASP5","F3","SOCS3","CCL2","STAT3","NBN","PTPN2","PAK1","MNDA","ANGPTL4","NUAK2","GCLC","SRC","TGFB1","KCNMA1","ROBO1","IL2RA","BCL2L15","CCL19","CDKN1A","UCP2","TXNIP","CTSC","IKBKE","RRAGC","UBE2Z","C19orf12","PTPN1","SORT1","NFKBIA","ACTN2","IFI6","GRINA","MCL1","LIG4","PKHD1","SH3RF1","LPAR1","PLEKHF1","PTGS2","ADAMTS20","GAS6","ASNS","CCL3","IRF5","CX3CL1","FOXC1","XKR7","PRELID1","CFLAR","TCIM","GATA3","BIRC7","CASP1","NKX3-1","NFE2L2","TNFRSF6B","IL33","SEMA4D","ELMO2","HERPUD1","DAPK2","BBC3"]} {"pathway":"GO_SMALL_MOLECULE_METABOLIC_PROCESS","pval":0.089,"padj":0.6584,"ES":0.5994,"NES":1.09795,"nMoreExtreme":8889,"size":1322,"leadingEdge":["APOL1","IDO1","PSME2","CD74","LRRK2","GCH1","PSMB9","CD38","APOL2","GK","PDE4B","CEACAM1","PLEK","PSME1","ACOD1","ATF3","IDO2","PSMB10","MYOF","PLAAT3","DPYS","IL4I1","GIMAP7","ACSL1","PSMB8","TYMP","CYP1A1","HSD3B7","OSBPL6","SCARF1","APOBEC3D","ENPP4","SOAT1","APOBEC3A","C3","APOBEC3G","CBR3","ACOT4","MTHFD2","SULT1C2","PPA1","EDN1","GTPBP1","DHRS9","PMAIP1","TTC39B","DGAT2","DYSF","CTNS","GGT5","CMPK2","GLUL","EPHX1","NR4A3","KYNU","SLC27A3","MYH7","APOBEC3F","PLA2G4C","TXN","SDSL","DECR1","TNF","CBR1","STAT5A","PSMA4","PSMA2","PFKP","CH25H","TCN2","PLA2G4A","ACSL5","CYP27B1","SLC25A25","PTAFR","NR1H3","ELOVL7","KMO","PTPN2","GCLC","SRC","LDHAL6B","ACSS1","HPD","PSMA5","ATP6V1A","ADA2","MMAA","NAGK","SLC7A2","RHOQ","PTGS2","GPD2","AMN","ACSM5","ASNS","CES1","ACPP","FUT4","ERLIN1","AK4","PLCB1","GLS","NADK","LMF1","ACBD5","GLRX","SCPEP1","SIK1","RFK","ESRRB","GALM","SEPHS2","KDSR","INSIG2","CPT1A","NPC1","ENTPD2","SDHB","ASS1","MTHFR","CBSL","ALDH1A2"]} {"pathway":"GO_RESPIRATORY_SYSTEM_PROCESS","pval":0.41466,"padj":0.89503,"ES":0.82577,"NES":1.09776,"nMoreExtreme":25806,"size":21,"leadingEdge":["ECEL1","GLS","FLT4"]} {"pathway":"GO_REGULATION_OF_SUPEROXIDE_METABOLIC_PROCESS","pval":0.37734,"padj":0.89036,"ES":0.79448,"NES":1.09741,"nMoreExtreme":24262,"size":27,"leadingEdge":["GCH1","AGT","TNF","FPR2","TGFB1","NFE2L2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_VIRAL_INDUCED_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY","pval":0.57023,"padj":0.93921,"ES":0.86654,"NES":1.09731,"nMoreExtreme":32559,"size":11,"leadingEdge":["DHX58","TSPAN6"]} {"pathway":"GO_RESPONSE_TO_ABIOTIC_STIMULUS","pval":0.12502,"padj":0.71645,"ES":0.59962,"NES":1.097,"nMoreExtreme":12442,"size":1001,"leadingEdge":["IRF1","PSME2","ASCL2","CD40","P2RX7","PSMB9","CD38","CXCL10","PSME1","STAT1","PSMB10","AGT","MYOF","TLR8","CCL7","FAS","PSMB8","KCNJ2","CAMK2D","VCAM1","CYP1A1","ICAM1","PML","S100A13","ABCB1","CTSS","CARD16","TMEM109","EDN1","VEGFC","PMAIP1","HSBP1L1","DYSF","CTNS","POLB","BACH1","PTGER4","RELB","LYN","IL12A","TIFAB","TLR7","CDS1","LTA","TANK","TFEC","MYD88","TLR3","TXN","TNF","PSMA4","SLC8A1","PSMA2","HPN","VGF","UBE2A","ASCL1","CXCL12","PTPRC","CHI3L1","SLC4A10","PTAFR","NR4A2","PSEN2","CASP5","KMO","GUCA1A","PAK1","ANGPTL4","GCLC","SRC","TGFB1","KCNMA1","CDKN1A","PSMA5","UCP2","TXNIP","ATP6V1A","NAMPT","HVCN1","NFKBIA","LIG4","LPAR1","PTGS2","ASNS","CFLAR","TCIM","GATA3","AGTRAP","CASP1","NKX3-1","NFE2L2","RCSD1","SMAD3","MICB","PDZD7","BAK1","IL1A","SIK1"]} {"pathway":"GO_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING","pval":0.2962,"padj":0.85691,"ES":0.66432,"NES":1.09681,"nMoreExtreme":23379,"size":102,"leadingEdge":["CEACAM1","HGF","JAK2","AGT","KLF4","BTN2A2","NCF1","CCL5","LYN","TNF","FLT1","RASGRP1","PIK3AP1","SRC","PDGFRA","NKX3-1","SEMA4D","PDGFB","PRR5L","PPP1R16B"]} {"pathway":"GO_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS","pval":0.22954,"padj":0.81508,"ES":0.61279,"NES":1.0967,"nMoreExtreme":21459,"size":343,"leadingEdge":["PSME2","LRRK2","LAMP3","ATP13A2","PSME1","NUB1","PML","RNF19B","DYSF","PYHIN1","AMER1","TNFAIP3","EDEM1","RNF144B","TNF","AZIN2","GCLC","CTSC","ADGRB1","NFE2L2","IL33","HERPUD1","SMAD3","NUPR1","RNF19A","AGAP2"]} {"pathway":"GO_REGULATION_OF_PHOSPHOLIPASE_C_ACTIVITY","pval":0.3519,"padj":0.88742,"ES":0.76495,"NES":1.09665,"nMoreExtreme":23360,"size":34,"leadingEdge":["ITK","AGT","FLT1","PTAFR","P2RY12","PDGFRA","LPAR1","EDNRA"]} {"pathway":"GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY","pval":0.28303,"padj":0.84565,"ES":0.64702,"NES":1.09654,"nMoreExtreme":23378,"size":137,"leadingEdge":["HGF","TNFSF10","ATF3","AGT","FAS","ICAM1","PML","CYLD","PMAIP1","IL7","TNFAIP3","FGF10","TNF","RBCK1","PTPRC","GCLC","SRC","IFI6","MCL1","SH3RF1","CX3CL1","CFLAR","TRAF1","IL1A"]} {"pathway":"GO_PEPTIDYL_CYSTEINE_MODIFICATION","pval":0.3352,"padj":0.87575,"ES":0.73492,"NES":1.0965,"nMoreExtreme":23191,"size":44,"leadingEdge":["ZDHHC19","ZDHHC18","ZDHHC11B","MIR212","ZDHHC23","NOS2"]} {"pathway":"GO_T_CELL_TOLERANCE_INDUCTION","pval":0.59092,"padj":0.94303,"ES":0.86365,"NES":1.09643,"nMoreExtreme":33354,"size":10,"leadingEdge":["IDO1","HLA-G","ICOS","IL2RA","LILRB2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS","pval":0.08762,"padj":0.65613,"ES":0.59842,"NES":1.09631,"nMoreExtreme":8753,"size":1383,"leadingEdge":["IRF1","GBP5","HLA-DPA1","IDO1","AIM2","CD40","CD74","P2RX7","SOCS1","CD274","LRRK2","GCH1","IL12RB1","CD38","IL15","PDE4B","HLA-DPB1","TBX21","NOD2","HLA-F","CEACAM1","PLEK","AMOT","CLEC9A","HGF","HLA-E","STAT1","HCAR2","JAK2","AGT","PIM1","RIPK2","TLR8","IL27","ACSL1","MCOLN2","CAMK2D","SPTBN4","ICAM1","KLF4","SCARF1","CLEC6A","ZBP1","IFITM1","ENPP4","FLT3LG","CD80","GSDMD","B2M","C3","SLAMF6","ZC3H12A","CYLD","P2RX4","RAPGEF2","SCIN","IRF7","NPR1","IL12RB2","RSAD2","ENPP2","BTN2A2","EDN1","VEGFC","IFIH1","MIR503","LILRA2","IL1RN","DDX60","C21orf91","GLIPR2","HLA-G","PTGER4","BCL6","LYN","IL12A","TLR7","CSF1","LTA","NR4A3","TNFRSF14","IL7","NRCAM","SOD2","CD83","IRF4","TNFAIP3","ANXA3","B4GALT5","RNF207","BIRC3","MYD88","IL6","TLR3","CLEC4E","LILRB4","FGF10","LTB","EGR3","DECR1","GADD45G","SEMA7A","NFKB2","TNF","SOX8","PTGER2","FST","STAT5A","EBI3","FLT1","SLC8A1","HPN","ADM2","CD226","DUSP10","CD86","RASGRP1","CAMK1D","CCL1","NCOA1","ASCL1","NTN1","CXCL12","CYP27B1","PTPRC","CHI3L1","LIPG","PTAFR","DDX58","LILRB1","F3","STAT3","P2RY12","DHX58","PAK1","ANGPTL4","TGIF2","RUNX1","SRC","TGFB1","SEMA4A","OCSTAMP","CCDC88B","ROBO1","IL2RA","CCL19","CGAS","CCR6","CXCL8","AKIRIN2","UCP2","P2RY2","ADGRB1","LIG4","ISG15","LPAR1","GPM6B","PTGS2","HAS2","GAS6","CCL3","IRF5","CX3CL1","FOXC1","CFLAR","GATA3","CASP1","NKX3-1","NFE2L2","IL33","PPARGC1B","LIN28A","SEMA4D"]} {"pathway":"GO_INTERLEUKIN_18_PRODUCTION","pval":0.62801,"padj":0.94878,"ES":0.83795,"NES":1.0961,"nMoreExtreme":34135,"size":7,"leadingEdge":["GBP5","CD84"]} {"pathway":"GO_GLYCEROPHOSPHOLIPID_CATABOLIC_PROCESS","pval":0.44892,"padj":0.90517,"ES":0.84162,"NES":1.09609,"nMoreExtreme":27312,"size":18,"leadingEdge":["ENPP2","PLA2G4C","PLA2G4A","GDE1"]} {"pathway":"GO_LYMPHOCYTE_COSTIMULATION","pval":0.33458,"padj":0.87575,"ES":0.72947,"NES":1.09577,"nMoreExtreme":23287,"size":46,"leadingEdge":["CD274","PDCD1LG2","CTLA4","TNFSF13B","CD80","PDCD1","LYN","TNFRSF14","CD86","PAK1","SRC","ICOS","CCL19"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TRANSPORT","pval":0.22705,"padj":0.81329,"ES":0.60998,"NES":1.09537,"nMoreExtreme":21412,"size":374,"leadingEdge":["GBP1","CD74","LRRK2","HLA-F","CEACAM1","BANK1","TLR8","CAMK2D","ICAM1","PRRT2","PML","SRI","CD300LF","ZC3H12A","CARD17","CARD16","RSAD2","BTN2A2","EDN1","DYSF","PTGER4","TIFAB","KCNE5","TNFAIP3","TXN","RSC1A1","TNF","CD47","GEM","ATG3","NR1H3","LILRB1","KCNE1","P2RY12","TRIM9","TGFB1","SNX16","UCP2","RHBDF2","ACTN2","GPM6B","PTGS2","GAS6","CX3CL1","SRCIN1","IL33","MIR212","ANKRD13A","SPINK1","CLIC2","IL1R2"]} {"pathway":"GO_GLYCOSYL_COMPOUND_METABOLIC_PROCESS","pval":0.32913,"padj":0.87227,"ES":0.72103,"NES":1.09535,"nMoreExtreme":23150,"size":50,"leadingEdge":["LRRK2","GIMAP7","TYMP","GTPBP1","RHOQ","ACPP","AK4"]} {"pathway":"GO_PROTEIN_K48_LINKED_UBIQUITINATION","pval":0.32548,"padj":0.87041,"ES":0.71511,"NES":1.09512,"nMoreExtreme":23110,"size":53,"leadingEdge":["NMI","IFI27","DTX3L","TNFAIP3","UBE2A","RNF115"]} {"pathway":"GO_LEUKOCYTE_MIGRATION","pval":0.23395,"padj":0.81652,"ES":0.61202,"NES":1.095,"nMoreExtreme":21857,"size":341,"leadingEdge":["ATP1B2","CD74","CXCL11","PDE4B","TBX21","CXCL10","CEACAM1","CCL13","SELL","CXCL9","PADI2","CCL7","MCOLN2","VCAM1","ICAM1","HSD3B7","CCL15","TNFSF18","CCL8","P2RX4","STAP1","EDN1","VEGFC","IL1RN","DYSF","SDC3","SLAMF8","PTGER4","CCL18","CCL5","LYN","IL12A","CSF1","TNFRSF14","CXCL16","IL6","TNF","FLT1","CH25H","GPR18","CD47","CAMK1D","SMPD3","CCR5","CCL1","ITGAL","CXCL12","PTAFR","CCL4","FPR2","CCL2","P2RY12","ITGB7","SRC","TGFB1","CCL19","CCR6","CXCL8","RIPOR2","CD48","GAS6","CCL3","CX3CL1","GATA3","IL33","DAPK2","PLCB1","PDGFB"]} {"pathway":"GO_RIBONUCLEOTIDE_CATABOLIC_PROCESS","pval":0.38468,"padj":0.89083,"ES":0.79753,"NES":1.09496,"nMoreExtreme":24612,"size":26,"leadingEdge":["PDE4B","PDE4A"]} {"pathway":"GO_RESPONSE_TO_METAL_ION","pval":0.24314,"padj":0.82387,"ES":0.61647,"NES":1.09491,"nMoreExtreme":22264,"size":290,"leadingEdge":["P2RX7","LRRK2","ATP13A2","SUCNR1","CAMK2D","VCAM1","CYP1A1","ICAM1","B2M","S100A13","P2RX4","EDN1","NCF1","MT2A","MT1M","MT1E","SMPD3","ASCL1","GUCA1A","GCLC","KCNMA1","SYT5","TXNIP","MT1H","HVCN1","LIG4","PTGS2","MT1G","NFE2L2","SYT17","IL1A","KCNMB1","NPC1","ASS1","SLC30A4"]} {"pathway":"GO_T_CELL_APOPTOTIC_PROCESS","pval":0.33903,"padj":0.87818,"ES":0.73661,"NES":1.09482,"nMoreExtreme":23344,"size":43,"leadingEdge":["IDO1","CD274","BCL2L11","PDCD1","JAK3","GIMAP8","CCL5","IL2RA","PRELID1","BAK1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_BLOOD_PRESSURE","pval":0.36574,"padj":0.89036,"ES":0.77509,"NES":1.09413,"nMoreExtreme":23942,"size":31,"leadingEdge":["GCH1","VEGFC","SOD2","ADM2","PTAFR","SCPEP1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY","pval":0.59227,"padj":0.94374,"ES":0.86174,"NES":1.09401,"nMoreExtreme":33430,"size":10,"leadingEdge":["CASP4","CASP1"]} {"pathway":"GO_REGULATION_OF_METANEPHROS_DEVELOPMENT","pval":0.45169,"padj":0.90517,"ES":0.8398,"NES":1.09372,"nMoreExtreme":27481,"size":18,"leadingEdge":["STAT1","PDGFB","HNF1B","WWTR1"]} {"pathway":"GO_REGULATION_OF_HISTONE_MODIFICATION","pval":0.29205,"padj":0.85228,"ES":0.65078,"NES":1.09371,"nMoreExtreme":23752,"size":124,"leadingEdge":["LRRK2","CAMK2D","MUC1","BCL6","AUTS2","TGFB1","GATA3","PAX5","MTHFR"]} {"pathway":"GO_PEPTIDE_CATABOLIC_PROCESS","pval":0.41159,"padj":0.89503,"ES":0.81686,"NES":1.09362,"nMoreExtreme":25753,"size":22,"leadingEdge":["ERAP2","GGT5","CHAC1","ERAP1","ENPEP"]} {"pathway":"GO_STEROID_METABOLIC_PROCESS","pval":0.26446,"padj":0.83501,"ES":0.62425,"NES":1.09341,"nMoreExtreme":23392,"size":221,"leadingEdge":["APOL1","APOL2","AGT","CYP1A1","HSD3B7","OSBPL6","SOAT1","HSD11B1","DHRS9","TTC39B","DGAT2","TNF","CH25H","CYP27B1","PDGFRA","CES1","ERLIN1","LMF1"]} {"pathway":"GO_ASPARTATE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS","pval":0.43951,"padj":0.90126,"ES":0.83379,"NES":1.09332,"nMoreExtreme":26993,"size":19,"leadingEdge":["ASNS","MTHFR","AASS"]} {"pathway":"GO_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS","pval":0.2837,"padj":0.846,"ES":0.64132,"NES":1.09328,"nMoreExtreme":23706,"size":148,"leadingEdge":["PLAAT4","SOCS1","PLEK","PLAAT3","PLA1A","CISH","TMEM150A","PLA2G4C","LPCAT2","PLA2G4A","SOCS3"]} {"pathway":"GO_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION","pval":0.31291,"padj":0.86489,"ES":0.67994,"NES":1.09322,"nMoreExtreme":23690,"size":79,"leadingEdge":["CXCL10","CXCL9","BHLHE41","FLT3LG","EDN1","TRIM72","PAK1","TGFB1","ADGRB1","RIPOR2","CFLAR","CD53","SIK1","FLOT1","TBX1","PROX1","HDAC4"]} {"pathway":"GO_ION_TRANSPORT","pval":0.11828,"padj":0.70259,"ES":0.59703,"NES":1.09307,"nMoreExtreme":11799,"size":1149,"leadingEdge":["SLC6A12","ATP1B2","APOL1","P2RX7","CALHM6","CXCL11","PDE4B","CXCL10","CEACAM1","ATP13A2","SLC31A2","CXCL9","SLC37A1","LMTK2","GRIN3A","KCNJ10","AGT","ABCC11","STEAP4","SLC12A3","ANO4","ACSL1","KCNJ2","MCOLN2","CAMK2D","SPTBN4","ICAM1","VPS9D1","KCNJ15","FLVCR2","PML","SRI","B2M","CCL8","RASGRF1","ABCB1","CTSS","P2RX4","SLC2A6","GJD3","TMEM109","EDN1","C15orf48","SCO2","LILRA2","SLC25A28","ANK2","SLC18A1","CLIC5","DYSF","CTNS","XKR6","CCL5","LYN","DTNBP1","SLC25A45","PLSCR4","KCNE5","PLSCR1","ANXA3","SLC27A3","SLCO4A1","RNF207","SLC51A","STAC3","JPH4","SLC8A1","HPN","TCN2","PLA2G4A","SLC25A22","SCN9A","AZIN2","CCR5","SLC12A7","NCOA1","XKR8","SLC26A11","CXCL12","GEM","CYP27B1","PTPRC","BSPRY","SLC25A25","SLC4A10","PTAFR","CCL4","LILRB1","KCNE1","PSEN2","CALHM5","CCL2","KMO","CACNA1I","P2RY12","TGFB1","KCNMA1","SYT5","CCL19","SLC22A1","SNX16","UCP2","ATP6V1A","SLC7A2","CLCN4","HVCN1","ACTN2","GABRR2","GLTPD2","GPM6B","PTGS2","GAS6","PARL","ABCC2","CCL3","MFSD2A","CX3CL1","XKR7","PRELID1","RGS9","TMEM63C","SLC44A2","ADAMTS8","MIR212","SPINK1","PLCB1","CLIC2","GLS","SLC8A2","PDGFB","NFKBIE","SYT17","GLRX","KCNE1B","BAK1","STOM","SIK1","FCER1G","LILRA5","SHISA7","SLC25A30","S100A1","ARC","SLC35C2","SLC31A1","MAPK8IP2","CCR1","CPT1A","KCNMB1","SLC9A4"]} {"pathway":"GO_NUCLEOSIDE_METABOLIC_PROCESS","pval":0.33949,"padj":0.87818,"ES":0.73005,"NES":1.09301,"nMoreExtreme":23569,"size":45,"leadingEdge":["LRRK2","GIMAP7","TYMP","GTPBP1","RHOQ","ACPP","AK4"]} {"pathway":"GO_ENDOSOME_ORGANIZATION","pval":0.31629,"padj":0.86626,"ES":0.68463,"NES":1.09296,"nMoreExtreme":23710,"size":74,"leadingEdge":["SNX10","CHMP4C","PLEKHF1","DNAJC13","RILP"]} {"pathway":"GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_HORMONE","pval":0.3979,"padj":0.89503,"ES":0.80582,"NES":1.0929,"nMoreExtreme":25199,"size":24,"leadingEdge":["SUCNR1","AGT","EDN1","CTSZ","CES1","ENPEP"]} {"pathway":"GO_ISOTYPE_SWITCHING_TO_IGA_ISOTYPES","pval":0.62935,"padj":0.94878,"ES":0.83548,"NES":1.09287,"nMoreExtreme":34208,"size":7,"leadingEdge":["TGFB1","CCR6","MLH1"]} {"pathway":"GO_RENAL_SYSTEM_PROCESS","pval":0.31354,"padj":0.86489,"ES":0.67968,"NES":1.0928,"nMoreExtreme":23738,"size":79,"leadingEdge":["SUCNR1","AGT","NPR1","EDN1","MYO1E","KCNMA1","HAS2","GAS6","PDGFB","ADORA2A","MYO5B"]} {"pathway":"GO_REGULATION_OF_VASCULATURE_DEVELOPMENT","pval":0.25345,"padj":0.82744,"ES":0.61806,"NES":1.09276,"nMoreExtreme":22951,"size":264,"leadingEdge":["CD40","CXCL10","CEACAM1","AMOT","HGF","STAT1","AGT","KLF4","PML","C3","ZC3H12A","RAPGEF2","NPR1","ENPP2","VEGFC","MIR503","HLA-G","GLUL","SOD2","TNFAIP3","ANXA3","IL6","TLR3","FLT1","ADM2","CHI3L1","F3","STAT3","ANGPTL4","RUNX1","SEMA4A","CXCL8","ADGRB1","PTGS2","CX3CL1","FOXC1","CFLAR","NFE2L2","MIR212","ERAP1","PDGFB"]} {"pathway":"GO_SUBPALLIUM_DEVELOPMENT","pval":0.43056,"padj":0.89981,"ES":0.8273,"NES":1.0922,"nMoreExtreme":26614,"size":20,"leadingEdge":["LRRK2","ASCL1","RARB"]} {"pathway":"GO_PHOSPHATIDYLINOSITOL_METABOLIC_PROCESS","pval":0.31049,"padj":0.86489,"ES":0.67105,"NES":1.09205,"nMoreExtreme":23919,"size":89,"leadingEdge":["SOCS1","PLEK","PLAAT3","CISH","TMEM150A","PLA2G4C","PLA2G4A","SOCS3","PLCB1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ANIMAL_ORGAN_MORPHOGENESIS","pval":0.39368,"padj":0.89503,"ES":0.80017,"NES":1.09194,"nMoreExtreme":25078,"size":25,"leadingEdge":["CEACAM1","STAT1","TNF","FOXC1","GATA3","HNF1B"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_ARSENIC_CONTAINING_SUBSTANCE","pval":0.45378,"padj":0.90517,"ES":0.8384,"NES":1.0919,"nMoreExtreme":27608,"size":18,"leadingEdge":["ATF3","ZC3H12A","GSTO2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES","pval":0.6299,"padj":0.94878,"ES":0.83444,"NES":1.09151,"nMoreExtreme":34238,"size":7,"leadingEdge":["TNF","HDAC6"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION","pval":0.31094,"padj":0.86489,"ES":0.66897,"NES":1.0912,"nMoreExtreme":24039,"size":91,"leadingEdge":["CD40","AGT","ZC3H12A","P2RX4","EDN1","VEGFC","ANXA3","STAT5A","TGFB1","PTGS2","GATA3","NFE2L2","PDGFB","MET","PROX1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_PROLIFERATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS","pval":0.59763,"padj":0.94558,"ES":0.79321,"NES":1.09113,"nMoreExtreme":31622,"size":5,"leadingEdge":["MIR503","NGFR"]} {"pathway":"GO_L_ALPHA_AMINO_ACID_TRANSMEMBRANE_TRANSPORT","pval":0.3549,"padj":0.88844,"ES":0.75082,"NES":1.09086,"nMoreExtreme":23873,"size":37,"leadingEdge":["KCNJ10","AGT","SLC25A22","SLC7A2","SLC25A13"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CYTOSKELETON_ORGANIZATION","pval":0.27497,"padj":0.83769,"ES":0.62614,"NES":1.09051,"nMoreExtreme":24002,"size":201,"leadingEdge":["P2RX7","PLEK","ICAM1","STAP1","SCIN","EDN1","S100A10","PPM1E","CD47","ACTR3C","PAK1","CDC42EP2","ACTN2","LPAR1","CX3CL1","AP1AR","SMAD3"]} {"pathway":"GO_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT","pval":0.27272,"padj":0.83739,"ES":0.62379,"NES":1.09047,"nMoreExtreme":24019,"size":214,"leadingEdge":["LRRK2","ATP13A2","IFI27","ZC3H12A","NUCB1","EDEM1","TXN","KCNE1","PAK1","TGFB1","PTPN1","PTGS2","GAS6","PARL","SMAD3","STOM","PRR5L","ARC","GCC2","RUFY3"]} {"pathway":"GO_SIGNAL_RELEASE_FROM_SYNAPSE","pval":0.29645,"padj":0.85691,"ES":0.64534,"NES":1.09031,"nMoreExtreme":24342,"size":132,"leadingEdge":["P2RX7","LRRK2","STX11","GRIN3A","ERC2","PRRT2","MCTP2","NAAA","DTNBP1","CADPS2","KMO","TRIM9","SYT5","NAPA","STX3","SYT17"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS","pval":0.3788,"padj":0.89036,"ES":0.78031,"NES":1.09017,"nMoreExtreme":24581,"size":29,"leadingEdge":["IDO1","CD74","JAK3","BCL6","CCL5","PRKCQ"]} {"pathway":"GO_PLASMA_LIPOPROTEIN_PARTICLE_CLEARANCE","pval":0.34898,"padj":0.88316,"ES":0.73866,"NES":1.08992,"nMoreExtreme":23850,"size":41,"leadingEdge":["SOAT1","DGAT2","LIPG","AMN","LMF1","NPC1","EHD1"]} {"pathway":"GO_IMPORT_INTO_CELL","pval":0.20613,"padj":0.79637,"ES":0.60016,"NES":1.0897,"nMoreExtreme":20057,"size":564,"leadingEdge":["ATP1B2","APOL1","LRRK2","SNX10","CEACAM1","CLEC9A","KCNJ10","AGT","SLC12A3","ACSL1","KCNJ2","SCARF1","KCNJ15","B2M","C3","CLEC10A","LGALS3BP","STAP1","RAB20","ENPP2","IGF2R","LY75","ANK2","SLC18A1","XKR6","GLUL","DENND1B","CXCL16","ARHGAP25","SLC8A1","FCHO1","SLC12A7","XKR8","NR1H3","LILRB1","FPR2","ACKR4","FCGR1A","MYO1E","SRC","SYT5","CCL19","SLC22A1","CXCL8","SLC7A2","PTPN1","RHOQ","SORT1","ADGRB1","GPM6B","FNBP1","AMN","XKR7","FCGR1B","ANKRD13A","DNAJC13","SYT17","ILDR1","FCER1G","C9orf72","FLOT1","ARC","RINL","SLC31A1","NPC1","SLC9A4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ACTIVATED_T_CELL_PROLIFERATION","pval":0.43388,"padj":0.90066,"ES":0.82532,"NES":1.08959,"nMoreExtreme":26819,"size":20,"leadingEdge":["IL12RB1","IL2RA","IGF1"]} {"pathway":"GO_REGULATION_OF_LOCOMOTION_INVOLVED_IN_LOCOMOTORY_BEHAVIOR","pval":0.4194,"padj":0.8957,"ES":0.7304,"NES":1.08943,"nMoreExtreme":21075,"size":2,"leadingEdge":["VPS35","ARRDC3"]} {"pathway":"GO_REGULATION_OF_PROTEIN_LOCALIZATION","pval":0.16852,"padj":0.77295,"ES":0.59639,"NES":1.08941,"nMoreExtreme":16702,"size":829,"leadingEdge":["AIM2","CD40","GBP1","P2RX7","SOCS1","CD274","LRRK2","CD38","NOD2","CLEC9A","ATP13A2","HLA-E","BANK1","TRIM17","HCAR2","JAK2","IFI27","RIPK2","TLR8","SIDT2","CLEC6A","GSDMD","TRIM22","PML","SRI","TLR10","ZC3H12A","CYLD","CARD17","CARD16","RSAD2","RALB","BTN2A2","VEGFC","IFIH1","DTX3L","PMAIP1","LILRA2","NUCB1","PTGER4","CCL5","LYN","PYHIN1","GLUL","TNFRSF14","PARP9","TNFAIP3","EDEM1","STAC3","IL6","CLEC4E","LILRB4","TXN","TNF","RASGRP1","CCL1","DDX58","NR1H3","LILRB1","KCNE1","PAK1","SRC","TGFB1","CCL19","UCP2","RHBDF2","PTPN1","RHOQ","ACTN2","MAP2","GPM6B","PTGS2","RIPOR2","GAS6","PARL","CCL3","CX3CL1","GATA3","CASP1","NKX3-1","SRCIN1","IL33","ANKRD13A","BBC3","NADK","IL1R2","SMAD3","STX3","GAS8","IL1A","STOM","PRR5L","FCER1G","TRIM46","LILRA5","SHISA7"]} {"pathway":"GO_POSITIVE_REGULATION_OF_B_CELL_MEDIATED_IMMUNITY","pval":0.36515,"padj":0.89036,"ES":0.76353,"NES":1.08941,"nMoreExtreme":24137,"size":33,"leadingEdge":["CD40","TBX21","HLA-E","C3","LTA","TNF","CD226","PTPRC","TGFB1","FCER1G"]} {"pathway":"GO_SYNAPTIC_VESICLE_LOCALIZATION","pval":0.29636,"padj":0.85691,"ES":0.64311,"NES":1.08936,"nMoreExtreme":24457,"size":136,"leadingEdge":["P2RX7","LRRK2","STX11","GRIN3A","ERC2","PRRT2","DTNBP1","CADPS2","TRIM9","SYT5","MAP2","NAPA","STX3","SYT17","TRIM46"]} {"pathway":"GO_ANTIMICROBIAL_HUMORAL_IMMUNE_RESPONSE_MEDIATED_BY_ANTIMICROBIAL_PEPTIDE","pval":0.40993,"padj":0.89503,"ES":0.80819,"NES":1.08911,"nMoreExtreme":25791,"size":23,"leadingEdge":["CXCL11","CXCL10","CCL13","CXCL9","CXCL8","CXCL1"]} {"pathway":"GO_INTERLEUKIN_17_PRODUCTION","pval":0.40345,"padj":0.89503,"ES":0.80294,"NES":1.08899,"nMoreExtreme":25550,"size":24,"leadingEdge":["IL15","NOD2","SLAMF6","IL12A","MYD88","MR1","CCL1","TGFB1","TLR4"]} {"pathway":"GO_REGULATION_OF_HETEROTYPIC_CELL_CELL_ADHESION","pval":0.4572,"padj":0.90517,"ES":0.83617,"NES":1.08899,"nMoreExtreme":27816,"size":18,"leadingEdge":["KLF4","IL1RN","TNF","FLOT1","CD44"]} {"pathway":"GO_RESPONSE_TO_ESTRADIOL","pval":0.31172,"padj":0.86489,"ES":0.66221,"NES":1.08868,"nMoreExtreme":24412,"size":98,"leadingEdge":["CD38","SSTR2","AGT","FGF10","NCOA1","STAT3","TGFB1","TXNIP","PTGS2","CFLAR","RGS9","ASS1","ALDH1A2","PTN"]} {"pathway":"GO_REGULATION_OF_T_HELPER_2_CELL_DIFFERENTIATION","pval":0.57685,"padj":0.94161,"ES":0.8597,"NES":1.08865,"nMoreExtreme":32937,"size":11,"leadingEdge":["BCL6","CD86","HLX","PRKCZ"]} {"pathway":"GO_REGULATION_OF_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS","pval":0.32086,"padj":0.86901,"ES":0.67706,"NES":1.0886,"nMoreExtreme":24292,"size":79,"leadingEdge":["LRRK2","BCL2L11","PMAIP1","EDEM1","PTPN2","PTPN1","GRINA","NFE2L2","HERPUD1","BAK1","EDEM2"]} {"pathway":"GO_REGULATION_OF_THE_FORCE_OF_HEART_CONTRACTION","pval":0.45829,"padj":0.90517,"ES":0.83552,"NES":1.08814,"nMoreExtreme":27882,"size":18,"leadingEdge":["CAMK2D","MYH7","SLC8A1","ATP2B4"]} {"pathway":"GO_MITOCHONDRIAL_DEPOLARIZATION","pval":0.4359,"padj":0.90126,"ES":0.82397,"NES":1.08782,"nMoreExtreme":26944,"size":20,"leadingEdge":["P2RX7","LRRK2","GCLC","SRC","IFI6"]} {"pathway":"GO_BODY_FLUID_SECRETION","pval":0.32774,"padj":0.87134,"ES":0.68596,"NES":1.08767,"nMoreExtreme":24337,"size":70,"leadingEdge":["NPR1","EDN1","OAS2","TIFAB","FGF10","STAT5A","NCOA1","NR1H3","P2RY2","NEUROG1"]} {"pathway":"GO_PREPULSE_INHIBITION","pval":0.62273,"padj":0.94878,"ES":0.81308,"NES":1.08723,"nMoreExtreme":33421,"size":6,"leadingEdge":["GRIN3A","ADORA2A"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CYTOKINE_SECRETION","pval":0.3377,"padj":0.87786,"ES":0.70996,"NES":1.08722,"nMoreExtreme":23978,"size":53,"leadingEdge":["GBP1","BANK1","TLR8","PML","ZC3H12A","CARD17","CARD16","BTN2A2","PTGER4","TNFAIP3","TNF","LILRB1","GAS6","CX3CL1","IL1R2","LILRA5"]} {"pathway":"GO_MACROMOLECULE_CATABOLIC_PROCESS","pval":0.12632,"padj":0.71997,"ES":0.59362,"NES":1.08713,"nMoreExtreme":12611,"size":1234,"leadingEdge":["UBD","PSME2","P2RX7","LRRK2","PSMB9","FBXO6","LAMP3","TBX21","CEACAM1","ATP13A2","PSME1","ISG20","PSMB10","NUB1","IFI27","UBE2L6","PSMB8","XRN1","SIDT2","SAMD4A","PML","RNF19B","ZC3H12A","CTSS","CYLD","CTSO","GTPBP1","DTX3L","PMAIP1","DYSF","SDC3","CHMP4C","OAS2","PYHIN1","CTRL","CTSL","AMER1","TNFAIP3","EDEM1","RNF144B","MYD88","CTSZ","TNF","PSMA4","PSMA2","SPOPL","RBCK1","CUL1","TRIM72","HELZ2","AZIN2","MOV10","UBE2A","TRIM71","TRIM9","GCLC","TGFB1","UVRAG","PSMA5","CTSC","UBE2Z","PTPN1","ADGRB1","ISG15","USP18","TRIM25","ERLIN1","NFE2L2","IL33","LIN28A","HERPUD1","ERI1","GNS","SMAD3","ZFP36","SCPEP1","PRR5L","NUPR1"]} {"pathway":"GO_ORGANIC_HYDROXY_COMPOUND_CATABOLIC_PROCESS","pval":0.34582,"padj":0.88254,"ES":0.72137,"NES":1.08692,"nMoreExtreme":24136,"size":47,"leadingEdge":["GK","HSD3B7","SCARF1","CYP27B1","GPD2","MTMR7"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION","pval":0.40585,"padj":0.89503,"ES":0.8014,"NES":1.0869,"nMoreExtreme":25702,"size":24,"leadingEdge":["RIPK2","CHI3L1","TGFB1","UBE2K"]} {"pathway":"GO_T_CELL_EXTRAVASATION","pval":0.62384,"padj":0.94878,"ES":0.84205,"NES":1.08684,"nMoreExtreme":34373,"size":8,"leadingEdge":["ICAM1","CCL2","CRKL"]} {"pathway":"GO_REGULATION_OF_CHEMOKINE_MEDIATED_SIGNALING_PATHWAY","pval":0.61381,"padj":0.94703,"ES":0.85047,"NES":1.08631,"nMoreExtreme":34301,"size":9,"leadingEdge":["PADI2","EDN1","CCL5","ROBO1","SLIT2"]} {"pathway":"GO_PHOSPHATIDYLCHOLINE_METABOLIC_PROCESS","pval":0.40096,"padj":0.89503,"ES":0.796,"NES":1.08625,"nMoreExtreme":25542,"size":25,"leadingEdge":["PLAAT4","PLAAT3","PLA2G4C","LPCAT2","PLA2G4A"]} {"pathway":"GO_SENSORY_PERCEPTION_OF_UMAMI_TASTE","pval":0.37034,"padj":0.89036,"ES":0.81466,"NES":1.08583,"nMoreExtreme":18530,"size":1,"leadingEdge":["ITPR3"]} {"pathway":"GO_METANEPHRIC_EPITHELIUM_DEVELOPMENT","pval":0.46101,"padj":0.90517,"ES":0.8337,"NES":1.08578,"nMoreExtreme":28048,"size":18,"leadingEdge":["STAT1","SOX8","PKD1"]} {"pathway":"GO_ENTRY_INTO_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION","pval":0.31163,"padj":0.86489,"ES":0.65102,"NES":1.08525,"nMoreExtreme":25001,"size":113,"leadingEdge":["CD74","IFITM2","ICAM1","IFITM1","CD80","SLAMF1","TRIM31","IFITM3","DYNLT1","HAVCR1","TNFRSF14","CD86","CCR5","ITGB7","SRC","CXCL8","UVRAG","TRIM21","GAS6","TRIM25"]} {"pathway":"GO_POSITIVE_REGULATION_OF_LIPID_KINASE_ACTIVITY","pval":0.38256,"padj":0.89036,"ES":0.7721,"NES":1.08442,"nMoreExtreme":24938,"size":30,"leadingEdge":["NOD2","LYN","FLT1","FPR2","P2RY12","SRC","TGFB1","CCL19","PDGFRA","PDGFB","AGAP2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELL_GROWTH_INVOLVED_IN_CARDIAC_MUSCLE_CELL_DEVELOPMENT","pval":0.62509,"padj":0.94878,"ES":0.83999,"NES":1.08418,"nMoreExtreme":34442,"size":8,"leadingEdge":["PAK1","CTDP1"]} {"pathway":"GO_ORGANIC_HYDROXY_COMPOUND_METABOLIC_PROCESS","pval":0.25813,"padj":0.82758,"ES":0.60498,"NES":1.08404,"nMoreExtreme":24211,"size":353,"leadingEdge":["APOL1","GCH1","APOL2","GK","PLEK","MYOF","CYP1A1","HSD3B7","OSBPL6","SOAT1","RAPGEF2","NPR1","DHRS9","TTC39B","DGAT2","DYSF","CTNS","EPHX1","TNF","HPN","CH25H","CYP27B1","PTAFR","NR4A2","ACSS1","GPD2","CES1","GATA3","ERLIN1","PLCB1","LMF1"]} {"pathway":"GO_CGMP_BIOSYNTHETIC_PROCESS","pval":0.62374,"padj":0.94878,"ES":0.81066,"NES":1.084,"nMoreExtreme":33475,"size":6,"leadingEdge":["NPR1","GUCY1A1","GUCY1B1"]} {"pathway":"GO_REGULATION_OF_GLUTAMATE_SECRETION","pval":0.61592,"padj":0.94834,"ES":0.84761,"NES":1.08266,"nMoreExtreme":34419,"size":9,"leadingEdge":["P2RX7","KMO","ADORA2A"]} {"pathway":"GO_GROWTH_HORMONE_RECEPTOR_SIGNALING_PATHWAY_VIA_JAK_STAT","pval":0.61608,"padj":0.94834,"ES":0.84738,"NES":1.08236,"nMoreExtreme":34428,"size":9,"leadingEdge":["JAK2","JAK3","LYN","STAT5A","STAT3","PTPN1"]} {"pathway":"GO_REGULATION_OF_BLOOD_VOLUME_BY_RENIN_ANGIOTENSIN","pval":0.55169,"padj":0.93273,"ES":0.76004,"NES":1.08233,"nMoreExtreme":28712,"size":4,"leadingEdge":["AGT","CYBA"]} {"pathway":"GO_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT","pval":0.32267,"padj":0.86974,"ES":0.65832,"NES":1.08229,"nMoreExtreme":25269,"size":98,"leadingEdge":["IFI27","ZC3H12A","TXN","TGFB1","PTGS2","GAS6","SMAD3"]} {"pathway":"GO_LACTATION","pval":0.36651,"padj":0.89036,"ES":0.74176,"NES":1.08227,"nMoreExtreme":24782,"size":38,"leadingEdge":["OAS2","STAT5A","NCOA1","CAD"]} {"pathway":"GO_ORGANONITROGEN_COMPOUND_BIOSYNTHETIC_PROCESS","pval":0.11372,"padj":0.69895,"ES":0.59062,"NES":1.08222,"nMoreExtreme":11363,"size":1514,"leadingEdge":["IDO1","P2RX7","GCH1","IL15","LAG3","BANK1","NMI","IDO2","TLR8","ACSL1","XRN1","TYMP","KLF4","MUC1","VPS9D1","SAMD4A","CD80","SOAT1","ZC3H12A","PARP10","JAK3","ALAS1","NPR1","TMTC1","PPA1","GTPBP1","CNDP2","PIWIL4","MIR503","SAT1","PCYT1A","GSTK1","SDC3","GCNT3","GGT5","ZDHHC19","CMPK2","CCL5","CHAC1","GLUL","TLR7","CDS1","DSE","PARP9","PLSCR1","IRF4","KYNU","B4GALT5","IL6","TLR3","CHST11","TNF","LPCAT2","HS3ST3B1","ZDHHC18","CD86","PLA2G4A","AZIN2","SMPD3","MOV10","ACSL5","ZDHHC11B","PTPRC","PTAFR","ST3GAL5","NR4A2","ELOVL7","KMO","TMTC2","STAT3","GUCA1A","TRIM71","GCLC","TGFB1","AGPAT3","ACSS1","CCL19","GALNT12","NAMPT","ADA2","MMAA","ST6GALNAC2","GUCY1A1","PTGS2","CHST2","HAS2","PLPP1","ASNS","MFSD2A","GUCY1B1","FUT4","SLC44A2","GATA3","NFE2L2","HS3ST3A1","LIN28A","MIR212","AK4","PLCB1","GLS","NADK","PDGFB","RAB38","LMF1","SPTA1","ZFP36","IL1A","RFK","PIGY","SEPHS2","SLC35C2","TLR4","KDSR","ZDHHC23","NPC1","ASS1","MTHFR","CBSL"]} {"pathway":"GO_BEHAVIORAL_RESPONSE_TO_PAIN","pval":0.6264,"padj":0.94878,"ES":0.83846,"NES":1.08221,"nMoreExtreme":34514,"size":8,"leadingEdge":["P2RX4","SCN9A","TSPO"]} {"pathway":"GO_ORGANOPHOSPHATE_ESTER_TRANSPORT","pval":0.3258,"padj":0.87041,"ES":0.66174,"NES":1.08217,"nMoreExtreme":25307,"size":93,"leadingEdge":["P2RX7","SLC37A1","ABCC11","ANO4","ABCB1","XKR6","PLSCR4","PLSCR1","XKR8","SLC25A25","GLTPD2","MFSD2A","XKR7","PRELID1"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_STEROID_HORMONE_STIMULUS","pval":0.2946,"padj":0.85515,"ES":0.62254,"NES":1.08204,"nMoreExtreme":25597,"size":195,"leadingEdge":["ACOD1","SSTR2","PADI2","JAK2","ICAM1","PAQR8","BCL2L11","EDN1","FAM107A","EPHX1","NR4A3","HNF4G","NCOA1","NR1H3","NR4A2","PAK1","RUNX1","SRC","TGFB1","CREBRF","PLPP1","CFLAR","NKX3-1","PPARGC1B","ZFP36","RORB","NCOA4","ESRRB","NPC1","ASS1"]} {"pathway":"GO_RNA_SPLICING","pval":0.25583,"padj":0.82758,"ES":0.60109,"NES":1.08188,"nMoreExtreme":24262,"size":400,"leadingEdge":["RBM11","RRAGC","PRPF3","CIR1","TSEN34","RBM5"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION","pval":0.35951,"padj":0.89036,"ES":0.72767,"NES":1.08153,"nMoreExtreme":24754,"size":43,"leadingEdge":["CXCL10","BHLHE41","TRIM72","PAK1","CFLAR","PDGFB","NFATC1","EREG","HDAC4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INSULIN_SECRETION","pval":0.35128,"padj":0.88663,"ES":0.71379,"NES":1.08151,"nMoreExtreme":24648,"size":49,"leadingEdge":["CD38","JAK2","SRI","GLUL","NADK"]} {"pathway":"GO_RESPONSE_TO_INTERLEUKIN_4","pval":0.38642,"padj":0.89277,"ES":0.77002,"NES":1.0815,"nMoreExtreme":25190,"size":30,"leadingEdge":["PML","CD300LF","JAK3","RUFY4","PARP14","IL2RG","PTPN2","GATA3","DCSTAMP"]} {"pathway":"GO_MEMBRANE_REPOLARIZATION","pval":0.3712,"padj":0.89036,"ES":0.74736,"NES":1.08125,"nMoreExtreme":24865,"size":36,"leadingEdge":["ATP1B2","KCNJ2","ANK2","KCNE5","RNF207","KCNE1","KCNE1B"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MESONEPHROS_DEVELOPMENT","pval":0.44413,"padj":0.90355,"ES":0.81897,"NES":1.0812,"nMoreExtreme":27453,"size":20,"leadingEdge":["AGT","SOX8","TGFB1","GATA3","SIX1"]} {"pathway":"GO_SMOOTH_MUSCLE_CONTRACTION","pval":0.3354,"padj":0.87575,"ES":0.67444,"NES":1.08101,"nMoreExtreme":25272,"size":77,"leadingEdge":["CD38","SSTR2","AGT","EDN1","COMP","TIFAB","SLC8A1","PTAFR","KCNMA1","GUCY1A1","PTGS2","EDNRA"]} {"pathway":"GO_REGULATION_OF_CARBOHYDRATE_CATABOLIC_PROCESS","pval":0.33924,"padj":0.87818,"ES":0.68158,"NES":1.08073,"nMoreExtreme":25191,"size":70,"leadingEdge":["P2RX7","STAT3","ESRRB","HDAC4"]} {"pathway":"GO_MORPHOGENESIS_OF_AN_EPITHELIUM","pval":0.24979,"padj":0.82413,"ES":0.598,"NES":1.08027,"nMoreExtreme":23936,"size":451,"leadingEdge":["PSME2","PSMB9","CXCL10","CEACAM1","HGF","PSME1","STAT1","PSMB10","AGT","PSMB8","KLF4","DNAAF1","TGM2","PML","EDN1","VEGFC","CSF1","PRKX","RNF207","CTSZ","FGF10","TNF","SOX8","PSMA4","PSMA2","NTN1","SOCS3","PAK1","TRIM71","PODXL","SRC","TGFB1","PSMA5"]} {"pathway":"GO_PEPTIDYL_LYSINE_MODIFICATION","pval":0.26742,"padj":0.83635,"ES":0.60298,"NES":1.08022,"nMoreExtreme":25067,"size":351,"leadingEdge":["EGR2","MUC1","TGM2","JADE2","IFIH1","BAZ1A","IRF4","NCOA1","AUTS2","TGFB1","GATA3","PAX5","GTF2B"]} {"pathway":"GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION","pval":0.31764,"padj":0.86701,"ES":0.64174,"NES":1.08013,"nMoreExtreme":25910,"size":126,"leadingEdge":["CD40","AGT","ZC3H12A","P2RX4","ENPP2","EDN1","VEGFC","GLIPR2","ANXA3","FGF10","STAT5A","SRC","TGFB1","CCR6","PTGS2","HAS2","GATA3","NFE2L2","PDGFB"]} {"pathway":"GO_MONOVALENT_INORGANIC_ANION_HOMEOSTASIS","pval":0.52723,"padj":0.92669,"ES":0.84869,"NES":1.08004,"nMoreExtreme":31032,"size":14,"leadingEdge":["SLC12A3","SLC12A7","CKB","SLC12A2"]} {"pathway":"GO_ZINC_ION_HOMEOSTASIS","pval":0.39232,"padj":0.89503,"ES":0.77304,"NES":1.08002,"nMoreExtreme":25458,"size":29,"leadingEdge":["ATP13A2","MT2A","MT1M","MT1E","MT1H","MT1G","SLC30A4"]} {"pathway":"GO_REGULATION_OF_NEURON_MATURATION","pval":0.60196,"padj":0.94684,"ES":0.85065,"NES":1.07993,"nMoreExtreme":33977,"size":10,"leadingEdge":["LRRK2","MAP3K13"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_AUTOPHAGY","pval":0.34015,"padj":0.87818,"ES":0.67858,"NES":1.07976,"nMoreExtreme":25383,"size":72,"leadingEdge":["LRRK2","HGF","STAT3","NAMPT","MCL1","NPC1","MET","LZTS1"]} {"pathway":"GO_CELL_CELL_SIGNALING_BY_WNT","pval":0.25322,"padj":0.82744,"ES":0.59815,"NES":1.07967,"nMoreExtreme":24208,"size":440,"leadingEdge":["PSME2","LRRK2","PSMB9","KREMEN1","PSME1","DKK2","PSMB10","PSMB8","KLF4","CMAHP","CYLD","TRABD2A","PTPRU","AMER1","TNFAIP3","FGF10","PSMA4","PSMA2","CUL1","MOV10","TCF7L1","NR4A2","RUNX1","SRC","VAX2","PSMA5"]} {"pathway":"GO_LIPID_CATABOLIC_PROCESS","pval":0.29031,"padj":0.85125,"ES":0.61339,"NES":1.0794,"nMoreExtreme":25979,"size":241,"leadingEdge":["PLAAT4","HCAR2","PLAAT3","HSD3B7","SCARF1","PLCXD2","PLA1A","ENPP2","PLA2G4C","DECR1","TNF","PLA2G4A","SMPD3","CYP27B1","LIPG","LIPH","MMAA","GM2A","CES1","PLCB1","ACBD5","DDHD1"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_STARVATION","pval":0.31804,"padj":0.86728,"ES":0.63959,"NES":1.07931,"nMoreExtreme":26060,"size":130,"leadingEdge":["LRRK2","ATF3","FAS","ZC3H12A","RALB","PMAIP1","GLUL","CADPS2","SIK1B","NUAK2","CDKN1A","UCP2","RRAGC","GAS6","ASNS","RRAGD","NFE2L2","SIK1"]} {"pathway":"GO_CELLULAR_TRIGLYCERIDE_HOMEOSTASIS","pval":0.62506,"padj":0.94878,"ES":0.80707,"NES":1.0792,"nMoreExtreme":33546,"size":6,"leadingEdge":["DGAT2","SIRT1"]} {"pathway":"GO_ALCOHOL_METABOLIC_PROCESS","pval":0.30662,"padj":0.86306,"ES":0.62647,"NES":1.07902,"nMoreExtreme":26157,"size":170,"leadingEdge":["APOL1","APOL2","GK","MYOF","SOAT1","DHRS9","TTC39B","DGAT2","DYSF","CH25H","CYP27B1","ACSS1","GPD2","CES1","ERLIN1","PLCB1","LMF1"]} {"pathway":"GO_REGULATION_OF_CD40_SIGNALING_PATHWAY","pval":0.62528,"padj":0.94878,"ES":0.80673,"NES":1.07874,"nMoreExtreme":33558,"size":6,"leadingEdge":["SLAMF1","TNFAIP3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC","pval":0.42334,"padj":0.89613,"ES":0.80048,"NES":1.07872,"nMoreExtreme":26635,"size":23,"leadingEdge":["GLUL","CCL2","KMO","PTGS2","ADORA2A"]} {"pathway":"GO_DEFENSE_RESPONSE_TO_FUNGUS","pval":0.51147,"padj":0.92419,"ES":0.84424,"NES":1.07864,"nMoreExtreme":30392,"size":15,"leadingEdge":["CLEC6A","TGFB1","FAM3A"]} {"pathway":"GO_3_UTR_MEDIATED_MRNA_DESTABILIZATION","pval":0.49637,"padj":0.91907,"ES":0.83917,"NES":1.07805,"nMoreExtreme":29733,"size":16,"leadingEdge":["ZC3H12A","MOV10","TRIM71","ZFP36","PLEKHN1","UPF1"]} {"pathway":"GO_REGULATION_OF_ACTIVIN_RECEPTOR_SIGNALING_PATHWAY","pval":0.46992,"padj":0.9079,"ES":0.82777,"NES":1.07805,"nMoreExtreme":28590,"size":18,"leadingEdge":["FGF10","FST","ZC3H3"]} {"pathway":"GO_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS","pval":0.34235,"padj":0.87929,"ES":0.67513,"NES":1.0778,"nMoreExtreme":25664,"size":74,"leadingEdge":["LRRK2","GCH1","HGF","NR4A3","SOD2","TXN","TNF","MCL1","NFE2L2","TLR4","MET","WNT1"]} {"pathway":"GO_VESICLE_LOCALIZATION","pval":0.28731,"padj":0.84886,"ES":0.6089,"NES":1.07767,"nMoreExtreme":26087,"size":269,"leadingEdge":["P2RX7","LRRK2","STX11","GRIN3A","ERC2","PRRT2","DTNBP1","CADPS2","CTSZ","RASGRP1","TRIM9","SYT5","CTSC","MAP2","AP1AR","NAPA","STX3","SYT17","TRIM46","CADPS","HAP1","ADORA2A","MLPH"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE","pval":0.56594,"padj":0.93517,"ES":0.85068,"NES":1.07723,"nMoreExtreme":32644,"size":12,"leadingEdge":["TBX21","BCL6","HLX","IFNL1"]} {"pathway":"GO_ANTIGEN_PROCESSING_AND_PRESENTATION_VIA_MHC_CLASS_IB","pval":0.51327,"padj":0.92459,"ES":0.84288,"NES":1.0769,"nMoreExtreme":30499,"size":15,"leadingEdge":["TAP2","HLA-F","HLA-B","HLA-E","HLA-A","HLA-C","B2M","HLA-G"]} {"pathway":"GO_SIGNAL_RELEASE","pval":0.27855,"padj":0.84118,"ES":0.60228,"NES":1.0768,"nMoreExtreme":25967,"size":336,"leadingEdge":["P2RX7","LRRK2","CD38","STX11","GRIN3A","HCAR2","JAK2","AGT","ERC2","SIDT2","PRRT2","SRI","MCTP2","EDN1","IL1RN","EXOC3L1","NAAA","CCL5","LYN","DTNBP1","GLUL","CADPS2","IL6","TNF","VGF","SMPD3","MAFA","KMO","TRIM9","SYT5","UCP2","GATA3","NKX3-1","NADK","NAPA","STX3","SYT17","ILDR1"]} {"pathway":"GO_PHOTOPERIODISM","pval":0.44973,"padj":0.90517,"ES":0.81547,"NES":1.07659,"nMoreExtreme":27799,"size":20,"leadingEdge":["PML","SIK1","FBXL3"]} {"pathway":"GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_DIFFERENTIATION","pval":0.39339,"padj":0.89503,"ES":0.76649,"NES":1.07655,"nMoreExtreme":25644,"size":30,"leadingEdge":["SOD2","TGFB1","PDGFB","NFATC1","EREG","SMARCD3"]} {"pathway":"GO_PRI_MIRNA_TRANSCRIPTION_BY_RNA_POLYMERASE_II","pval":0.36874,"padj":0.89036,"ES":0.72669,"NES":1.07618,"nMoreExtreme":25285,"size":42,"leadingEdge":["KLF4","LILRB4","STAT3","TGFB1","PDGFB","SMAD3","HDAC4"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION","pval":0.35526,"padj":0.88844,"ES":0.6978,"NES":1.07577,"nMoreExtreme":25415,"size":56,"leadingEdge":["GBP1","MIR503","FAM107A","BCL6","SRC","CX3CL1","AP1AR","WNT1","SEMA3E"]} {"pathway":"GO_MYELOID_LEUKOCYTE_DIFFERENTIATION","pval":0.31383,"padj":0.86489,"ES":0.62404,"NES":1.07524,"nMoreExtreme":26781,"size":171,"leadingEdge":["IL31RA","UBD","CD74","SNX10","CEACAM1","BATF2","BATF3","LILRB3","IRF7","SBNO2","RELB","LYN","CSF1","IRF4","TLR3","LILRB4","NOTCH2","TNF","FARP2","LILRB1","PTPN2","RUNX1","SRC","TGFB1","OCSTAMP","CCL19","C1QC","CCL3","GATA3","MT1G","PPARGC1B"]} {"pathway":"GO_ER_NUCLEUS_SIGNALING_PATHWAY","pval":0.36689,"padj":0.89036,"ES":0.7179,"NES":1.07483,"nMoreExtreme":25471,"size":45,"leadingEdge":["ATF3","BCL2L11","CCL2","PTPN2","CXCL8","PTPN1","ASNS","ERLIN1","NFE2L2","HERPUD1","INSIG2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE","pval":0.62068,"padj":0.94878,"ES":0.84133,"NES":1.07463,"nMoreExtreme":34685,"size":9,"leadingEdge":["SERPING1","A2M","FCGR2B"]} {"pathway":"GO_REGULATION_OF_SYSTEM_PROCESS","pval":0.27327,"padj":0.83739,"ES":0.59657,"NES":1.07448,"nMoreExtreme":25971,"size":409,"leadingEdge":["ATP1B2","LRRK2","GCH1","CD38","PDE4B","HGF","SSTR2","HCAR2","JAK2","AGT","KCNJ2","CAMK2D","TYMP","SPTBN4","ICAM1","KLF4","SRI","ZC3H12A","P2RX4","NPR1","GJD3","EDN1","ANK2","TIFAB","NR4A3","KCNE5","MYH7","RNF207","FGF10","PTGER2","SLC8A1","DES","PTAFR","NR1H3","KCNE1","PAK1","SRC","KCNMA1","GUCY1A1","PTGS2","GAS6","CCL3","ACPP","NKX3-1","CLIC2","GLS","SLC8A2","PDGFB","SMAD3"]} {"pathway":"GO_REGULATION_OF_NECROTIC_CELL_DEATH","pval":0.42896,"padj":0.89886,"ES":0.79709,"NES":1.07415,"nMoreExtreme":26988,"size":23,"leadingEdge":["CYLD","BIRC3","RBCK1","CFLAR","HEBP2"]} {"pathway":"GO_REGULATION_OF_MRNA_PROCESSING","pval":0.33082,"padj":0.87332,"ES":0.63977,"NES":1.07371,"nMoreExtreme":26840,"size":122,"leadingEdge":["RBM11","RBM5"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MAPK_CASCADE","pval":0.27296,"padj":0.83739,"ES":0.59488,"NES":1.07288,"nMoreExtreme":26030,"size":429,"leadingEdge":["CD40","CD74","P2RX7","LRRK2","NOD2","CCL13","HGF","BANK1","JAK2","RIPK2","CCL7","ICAM1","CCL15","CCL8","SCIMP","ZC3H12A","RAPGEF2","EDN1","SLAMF1","NCF1","NRK","IL1RN","GADD45B","GLIPR2","CCL18","CCL5","GAREM1","IL6","TLR3","FGF10","GADD45G","SEMA7A","NOTCH2","TNF","FLT1","RASGRP1","CCL1","FGD2","PTPRC","CHI3L1","CCL4","FPR2","CCL2","PAK1","SRC","TGFB1","ROBO1","CCL19","PDGFRA","DUSP5","PTPN1","SH3RF1","LPAR1","GAS6","CCL3","CX3CL1","CFLAR","BIRC7","PLCB1","PDGFB"]} {"pathway":"GO_MAINTENANCE_OF_GASTROINTESTINAL_EPITHELIUM","pval":0.6061,"padj":0.94703,"ES":0.84505,"NES":1.07282,"nMoreExtreme":34211,"size":10,"leadingEdge":["NOD2","TLR4","STRAP"]} {"pathway":"GO_L_GLUTAMATE_TRANSMEMBRANE_TRANSPORT","pval":0.48815,"padj":0.91689,"ES":0.82954,"NES":1.07278,"nMoreExtreme":29498,"size":17,"leadingEdge":["KCNJ10","SLC25A22","SLC25A13"]} {"pathway":"GO_CELL_REDOX_HOMEOSTASIS","pval":0.35341,"padj":0.888,"ES":0.67896,"NES":1.07275,"nMoreExtreme":26113,"size":68,"leadingEdge":["NCF1","SCO2","TXN","GCLC","PRDX1","HVCN1","NME8","NCF2","NFE2L2","GLRX","KRIT1"]} {"pathway":"GO_REGULATION_OF_MICROGLIAL_CELL_ACTIVATION","pval":0.46488,"padj":0.90571,"ES":0.81795,"NES":1.07256,"nMoreExtreme":28551,"size":19,"leadingEdge":["LRRK2","STAP1","IL6","TNF","PTPRC","CCL3","CX3CL1"]} {"pathway":"GO_ANTIBIOTIC_BIOSYNTHETIC_PROCESS","pval":0.58895,"padj":0.94172,"ES":0.84671,"NES":1.0722,"nMoreExtreme":33628,"size":11,"leadingEdge":["CYP1A1","CTNS","STAT3","FYN"]} {"pathway":"GO_PROTEIN_AUTOPHOSPHORYLATION","pval":0.31328,"padj":0.86489,"ES":0.61466,"NES":1.07214,"nMoreExtreme":27436,"size":206,"leadingEdge":["LRRK2","ITK","ATP13A2","LMTK2","JAK2","PIM1","CAMK2D","VEGFC","MVP","LYN","VRK2","PRKX","FLT1","PTPRC","NBN","PAK1","SRC","PDGFRA","DAPK2","PDGFB","SIK1"]} {"pathway":"GO_ANION_TRANSMEMBRANE_TRANSPORT","pval":0.31691,"padj":0.86626,"ES":0.6182,"NES":1.0721,"nMoreExtreme":27412,"size":188,"leadingEdge":["SLC6A12","APOL1","SLC37A1","KCNJ10","AGT","SLC12A3","ABCB1","CLIC5","SLC25A22","SLC12A7","SLC26A11","SLC4A10","PTAFR","SLC7A2","CLCN4","GABRR2","ADAMTS8","CLIC2","SLC25A30","SLC35C2","CPT1A"]} {"pathway":"GO_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA","pval":0.37243,"padj":0.89036,"ES":0.71849,"NES":1.07198,"nMoreExtreme":25767,"size":44,"leadingEdge":["HGF","TNFSF10","BCL2L11","PMAIP1","PRELID1","BBC3","BAK1"]} {"pathway":"GO_CAVEOLIN_MEDIATED_ENDOCYTOSIS","pval":0.62243,"padj":0.94878,"ES":0.83925,"NES":1.07197,"nMoreExtreme":34783,"size":9,"leadingEdge":["SRC","NEDD4L"]} {"pathway":"GO_ANIMAL_ORGAN_MORPHOGENESIS","pval":0.22832,"padj":0.81508,"ES":0.58707,"NES":1.07181,"nMoreExtreme":22594,"size":786,"leadingEdge":["PSME2","P2RX7","LRRK2","ETV7","SNX10","PSMB9","CEACAM1","HGF","PSME1","STAT1","PSMB10","AGT","PIM1","TMEM176B","ONECUT2","BHLHE41","PSMB8","BCL2L11","DNAAF1","TGM2","PML","FAM20A","EDN1","VEGFC","COMP","POLB","GCNT3","TIFAB","CSF1","NR4A3","IL7","PRKX","TNFAIP3","MYH7","RNF207","CTSZ","FGF10","NOTCH2","CHST11","TNF","SOX8","PSMA4","PSMA2","HPN","CUL1","SMPD3","NTN1","SLC4A10","AUTS2","CCL2","STAT3","SRC","TGFB1","VAX2","ROBO1","PSMA5","PDGFRA","HAS2","HOXD8","FOXC1","CFLAR","GATA3","NKX3-1","PPARGC1B","TDRD7","SMAD3","PDZD7","SLIT2","BAK1","RORB","PAX5","HLX","HOXD11","COL8A2","ARID5B","HEG1","INSIG2"]} {"pathway":"GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC","pval":0.36979,"padj":0.89036,"ES":0.71349,"NES":1.07175,"nMoreExtreme":25738,"size":46,"leadingEdge":["LRRK2","GRM8","GLUL","TNF","CCL2","KMO","PTGS2","MAPK8IP2","ADORA2A"]} {"pathway":"GO_APICAL_JUNCTION_ASSEMBLY","pval":0.36351,"padj":0.89036,"ES":0.70174,"NES":1.07161,"nMoreExtreme":25734,"size":52,"leadingEdge":["MARVELD2","TNF","RUNX1","SNAI2"]} {"pathway":"GO_REGULATION_OF_TOLL_LIKE_RECEPTOR_4_SIGNALING_PATHWAY","pval":0.48929,"padj":0.91689,"ES":0.82861,"NES":1.07158,"nMoreExtreme":29567,"size":17,"leadingEdge":["ACOD1","LILRA2","LYN","TICAM2","TNFAIP3","NR1H3","WDFY1"]} {"pathway":"GO_NEUROMUSCULAR_PROCESS_CONTROLLING_BALANCE","pval":0.38745,"padj":0.89277,"ES":0.74385,"NES":1.07138,"nMoreExtreme":25823,"size":35,"leadingEdge":["TIFAB","NR4A3","JPH4","NBN","GM2A","NEUROG1"]} {"pathway":"GO_REGULATION_OF_RNA_SPLICING","pval":0.33604,"padj":0.87575,"ES":0.63977,"NES":1.07138,"nMoreExtreme":27155,"size":119,"leadingEdge":["RBM11","RBM5"]} {"pathway":"GO_BLOOD_COAGULATION_INTRINSIC_PATHWAY","pval":0.63198,"padj":0.94878,"ES":0.82999,"NES":1.07128,"nMoreExtreme":34822,"size":8,"leadingEdge":["SERPING1","A2M","GP1BA"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS","pval":0.40092,"padj":0.89503,"ES":0.7627,"NES":1.07122,"nMoreExtreme":26135,"size":30,"leadingEdge":["HGF","TNFSF10","FAS","ICAM1","TNFAIP3","CFLAR"]} {"pathway":"GO_TOLL_LIKE_RECEPTOR_9_SIGNALING_PATHWAY","pval":0.45675,"padj":0.90517,"ES":0.81134,"NES":1.07113,"nMoreExtreme":28233,"size":20,"leadingEdge":["TLR8","RSAD2","TLR7","LILRA4","MYD88","PIK3AP1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS","pval":0.37659,"padj":0.89036,"ES":0.72319,"NES":1.071,"nMoreExtreme":25823,"size":42,"leadingEdge":["LRRK2","PTPN1","GRINA","HERPUD1"]} {"pathway":"GO_COBALAMIN_METABOLIC_PROCESS","pval":0.50475,"padj":0.91988,"ES":0.83333,"NES":1.07055,"nMoreExtreme":30235,"size":16,"leadingEdge":["TCN2","MMAA","AMN","ABCC1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVATING_ADRENERGIC_RECEPTOR_SIGNALING_PATHWAY","pval":0.48461,"padj":0.91689,"ES":0.72639,"NES":1.07019,"nMoreExtreme":24773,"size":3,"leadingEdge":["ATP2B4","ARRDC3","GNAI2"]} {"pathway":"GO_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVATING_ADRENERGIC_RECEPTOR_SIGNALING_PATHWAY_INVOLVED_IN_HEART_PROCESS","pval":0.48461,"padj":0.91689,"ES":0.72639,"NES":1.07019,"nMoreExtreme":24773,"size":3,"leadingEdge":["ATP2B4","NOS1","GNAI2"]} {"pathway":"GO_SECRETORY_GRANULE_LOCALIZATION","pval":0.62374,"padj":0.94878,"ES":0.83776,"NES":1.07008,"nMoreExtreme":34856,"size":9,"leadingEdge":["RASGRP1","MAP2","TRIM46","KIF1B"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN","pval":0.33021,"padj":0.87332,"ES":0.6283,"NES":1.06997,"nMoreExtreme":27539,"size":146,"leadingEdge":["ATF3","OPTN","BCL2L11","EDEM1","CCL2","PTPN2","CXCL8","PTPN1","CREBRF","ASNS","NFE2L2","HERPUD1","BAK1"]} {"pathway":"GO_DEFENSE_RESPONSE_TO_BACTERIUM","pval":0.3394,"padj":0.87818,"ES":0.63986,"NES":1.06985,"nMoreExtreme":27356,"size":117,"leadingEdge":["P2RX7","NOD2","HLA-E","OPTN","RIPK2","GSDMD","GBP6","SLAMF8","IL12A","LTA","TNFRSF14","ANXA3","MYD88","IL6","TLR3","CLEC4D","CLEC4E","TNF","MR1","VGF","ADGRB1","ISG15","MPEG1","FCER1G","IRF8","TLR4","SIGLEC11","PLAC8"]} {"pathway":"GO_CELLULAR_LIPID_METABOLIC_PROCESS","pval":0.24902,"padj":0.82387,"ES":0.58702,"NES":1.06972,"nMoreExtreme":24506,"size":683,"leadingEdge":["PLAAT4","P2RX7","SOCS1","GK","NOD2","PLEK","ACOD1","AGT","PLAAT3","ACSL1","CYP1A1","KLF4","SOAT1","C3","ACOT4","PLA1A","ENPP2","DHRS9","CISH","DGAT2","SDC3","GGT5","LYN","NR4A3","TMEM150A","SLC27A3","B4GALT5","PLA2G4C","DECR1","TNF","CBR1","LPCAT2","FLT1","DGKG","PLA2G4A","SMPD3","ACSL5","LIPG","ST3GAL5","NR1H3","FPR2","ELOVL7","SOCS3","P2RY12","SRC","TGFB1","AGPAT3","CCL19","PDGFRA","MMAA","GM2A","PTGS2","PLPP1","CES1","PLCB1","PDGFB","LMF1","ACBD5","SIK1","PIGY","KDSR","AGAP2","INSIG2","CPT1A","PLPPR4","ALDH1A2","FAM135A"]} {"pathway":"GO_REGULATION_OF_BLOOD_CIRCULATION","pval":0.3199,"padj":0.86901,"ES":0.61419,"NES":1.0697,"nMoreExtreme":27924,"size":201,"leadingEdge":["ATP1B2","GCH1","CD38","PDE4B","JAK2","AGT","KCNJ2","CAMK2D","SPTBN4","ICAM1","SRI","ZC3H12A","P2RX4","NPR1","GJD3","EDN1","ANK2","KCNE5","MYH7","RNF207","PTGER2","SLC8A1","DES","PTAFR","KCNE1"]} {"pathway":"GO_THIOESTER_METABOLIC_PROCESS","pval":0.38338,"padj":0.89036,"ES":0.7297,"NES":1.06938,"nMoreExtreme":26039,"size":39,"leadingEdge":["ACOT4","DGAT2","ACSM5","ACSM3"]} {"pathway":"GO_ENTRAINMENT_OF_CIRCADIAN_CLOCK_BY_PHOTOPERIOD","pval":0.46874,"padj":0.90755,"ES":0.81548,"NES":1.06931,"nMoreExtreme":28788,"size":19,"leadingEdge":["PML","SIK1","FBXL3"]} {"pathway":"GO_SMOOTH_MUSCLE_CELL_PROLIFERATION","pval":0.34025,"padj":0.87818,"ES":0.63903,"NES":1.06928,"nMoreExtreme":27456,"size":118,"leadingEdge":["IL15","STAT1","JAK2","AGT","KLF4","TGM2","NPR1","EDN1","MIR503","CCL5","IL12A","NR4A3","SOD2","TNFAIP3","IL6","TNF","SMPD3","PTAFR","PAK1","CDKN1A","NAMPT","PTGS2","CX3CL1","PDGFB"]} {"pathway":"GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_SECRETION","pval":0.62449,"padj":0.94878,"ES":0.83705,"NES":1.06916,"nMoreExtreme":34898,"size":9,"leadingEdge":["HLA-E","IL6","IL33"]} {"pathway":"GO_TRANSPOSITION","pval":0.45971,"padj":0.90517,"ES":0.80951,"NES":1.06872,"nMoreExtreme":28416,"size":20,"leadingEdge":["APOBEC3D","APOBEC3A","APOBEC3G","PIWIL4","TDRD9","APOBEC3F","MOV10"]} {"pathway":"GO_GLAND_MORPHOGENESIS","pval":0.34639,"padj":0.88258,"ES":0.64929,"NES":1.0686,"nMoreExtreme":27174,"size":99,"leadingEdge":["CEACAM1","HGF","TGM2","PML","POLB","CSF1","TNFAIP3","FGF10","TNF","HPN","NTN1","SRC","TGFB1","CFLAR","NKX3-1"]} {"pathway":"GO_COFACTOR_TRANSPORT","pval":0.38771,"padj":0.89277,"ES":0.73543,"NES":1.0685,"nMoreExtreme":26080,"size":37,"leadingEdge":["P2RX7","FLVCR2","SLC25A45","TCN2","AMN"]} {"pathway":"GO_VITAMIN_D_METABOLIC_PROCESS","pval":0.60918,"padj":0.94703,"ES":0.84142,"NES":1.06821,"nMoreExtreme":34385,"size":10,"leadingEdge":["CYP1A1","CYP27B1","LRP2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INTERLEUKIN_10_PRODUCTION","pval":0.41655,"padj":0.89503,"ES":0.7731,"NES":1.06788,"nMoreExtreme":26783,"size":27,"leadingEdge":["CD274","NOD2","HGF","CD83","IRF4","FCER1G","LILRA5","TLR4"]} {"pathway":"GO_PROTEIN_MATURATION","pval":0.3204,"padj":0.86901,"ES":0.60905,"NES":1.06779,"nMoreExtreme":28401,"size":225,"leadingEdge":["P2RX7","LRRK2","RIPK2","CTSS","CARD16","C1RL","COMP","C1R","CHAC1","BIRC3","CTSZ","HPN","PSEN2","F3","SRC","PLGRKT","CES1","BIRC7","CASP1","IL1R2","LMF1","KLK1","BAK1","NGF"]} {"pathway":"GO_PROSTATE_GLAND_MORPHOGENESIS","pval":0.43766,"padj":0.90126,"ES":0.79221,"NES":1.06757,"nMoreExtreme":27536,"size":23,"leadingEdge":["FGF10","NKX3-1","TNC"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS","pval":0.27741,"padj":0.84047,"ES":0.5889,"NES":1.06731,"nMoreExtreme":26847,"size":517,"leadingEdge":["GBP1","P2RX7","SOCS1","LRRK2","CEACAM1","HGF","ATF3","LMTK2","KLF4","ZC3H12A","PARP10","CYLD","BTN2A2","DTX3L","MIR503","MVP","GADD45B","DYSF","PPM1E","LYN","DTNBP1","PARP14","TNFAIP3","TNF","SPOPL","DUSP10","PTPRC","SOCS3","PTPN2","GCLC","TGFB1","CDKN1A","TRIM21","ADAR","DUSP5","CDKN1C","PTPN1","ADGRB1","ISG15","ELFN1","SRCIN1","MIR212","SEMA4D","SPINK1","SLIT2","BAK1","PRR5L","MYOZ1","PAX5","C9orf72","PPP1R16B","HEG1","TLR4"]} {"pathway":"GO_KERATINOCYTE_PROLIFERATION","pval":0.41283,"padj":0.89503,"ES":0.76802,"NES":1.06731,"nMoreExtreme":26667,"size":28,"leadingEdge":["FGF10","HAS2","ZFP36","EREG","SNAI2"]} {"pathway":"GO_NATURAL_KILLER_CELL_ACTIVATION","pval":0.36906,"padj":0.89036,"ES":0.69229,"NES":1.06727,"nMoreExtreme":26402,"size":56,"leadingEdge":["SLAMF7","IL15","HLA-F","HLA-E","FLT3LG","IL12A","RASGRP1","PTPRC","PRDX1","GAS6","IL21R","MICB"]} {"pathway":"GO_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION","pval":0.32795,"padj":0.87134,"ES":0.61481,"NES":1.06695,"nMoreExtreme":28411,"size":190,"leadingEdge":["CD74","CEACAM1","STAT1","LILRB3","B2M","SCIN","IRF7","LYN","CSF1","NR4A3","TLR3","LILRB4","NOTCH2","TNF","MOV10","LILRB1","STAT3","PTPN2","RUNX1","TGFB1","OCSTAMP","C1QC","GP1BA","NFKBIA","ISG15","CCL3","PPARGC1B","ZFP36","TLR4","CCR1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_DIFFERENTIATION","pval":0.61025,"padj":0.94703,"ES":0.84026,"NES":1.06674,"nMoreExtreme":34445,"size":10,"leadingEdge":["SOD2","TGFB1","SMARCD3","PIAS1"]} {"pathway":"GO_PROTEIN_K63_LINKED_UBIQUITINATION","pval":0.37965,"padj":0.89036,"ES":0.71228,"NES":1.06642,"nMoreExtreme":26357,"size":45,"leadingEdge":["NOD2","PARP10","RNF115"]} {"pathway":"GO_REGULATION_OF_MYOBLAST_DIFFERENTIATION","pval":0.38741,"padj":0.89277,"ES":0.72482,"NES":1.06595,"nMoreExtreme":26407,"size":40,"leadingEdge":["CXCL10","CXCL9","FLT3LG","TNF","SOX8","TGFB1","RIPOR2","PLCB1","BOC","PRICKLE1"]} {"pathway":"GO_HOMOTYPIC_CELL_CELL_ADHESION","pval":0.36845,"padj":0.89036,"ES":0.67937,"NES":1.06546,"nMoreExtreme":26981,"size":64,"leadingEdge":["CEACAM1","PLEK","TSPAN32","COMP","CCL5","LYN","PTPRU","P2RY12","GP1BA","PDGFRA","GAS6"]} {"pathway":"GO_REGULATION_OF_INTERFERON_GAMMA_SECRETION","pval":0.64054,"padj":0.94878,"ES":0.81441,"NES":1.06532,"nMoreExtreme":34816,"size":7,"leadingEdge":["ZC3H12A","RASGRP1","CD244"]} {"pathway":"GO_METANEPHRIC_NEPHRON_EPITHELIUM_DEVELOPMENT","pval":0.52594,"padj":0.92669,"ES":0.83371,"NES":1.06518,"nMoreExtreme":31252,"size":15,"leadingEdge":["STAT1","SOX8","PKD1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS","pval":0.34589,"padj":0.88254,"ES":0.63172,"NES":1.06514,"nMoreExtreme":28306,"size":129,"leadingEdge":["GSAP","SAMD4A","CCL5","IL6","TNF","SMPD3","PTAFR","NFE2L2","LIN28A"]} {"pathway":"GO_HEART_PROCESS","pval":0.33033,"padj":0.87332,"ES":0.61155,"NES":1.0651,"nMoreExtreme":28834,"size":201,"leadingEdge":["ATP1B2","GCH1","PDE4B","JAK2","AGT","KCNJ2","CAMK2D","SPTBN4","SRI","ZC3H12A","P2RX4","NPR1","GJD3","EDN1","ANK2","KCNE5","MYH7","RNF207","SLC8A1","DES","KCNE1","SRC"]} {"pathway":"GO_INTEGRIN_ACTIVATION","pval":0.49699,"padj":0.91907,"ES":0.82349,"NES":1.06495,"nMoreExtreme":30032,"size":17,"leadingEdge":["PLEK","PTGER4","FARP2","CXCL12","P2RY12","SRC","CX3CL1"]} {"pathway":"GO_UTERINE_SMOOTH_MUSCLE_CONTRACTION","pval":0.63013,"padj":0.94878,"ES":0.79619,"NES":1.06465,"nMoreExtreme":33818,"size":6,"leadingEdge":["AGT","GPER1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY","pval":0.39861,"padj":0.89503,"ES":0.74259,"NES":1.06459,"nMoreExtreme":26461,"size":34,"leadingEdge":["ACOD1","CD300LF","LILRA2","LYN","TICAM2","IRF4","TNFAIP3","LILRA4","TLR3","OTUD4","TLR4","TICAM1"]} {"pathway":"GO_CELLULAR_PROTEIN_CONTAINING_COMPLEX_LOCALIZATION","pval":0.43018,"padj":0.89981,"ES":0.77996,"NES":1.06436,"nMoreExtreme":27403,"size":25,"leadingEdge":["TNFAIP2","EXOC3L4","RALB","EXOC3L1","NUP133"]} {"pathway":"GO_MOTILE_CILIUM_ASSEMBLY","pval":0.51168,"padj":0.92419,"ES":0.82844,"NES":1.06427,"nMoreExtreme":30650,"size":16,"leadingEdge":["DNAAF1","MKS1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELL_DEATH","pval":0.25437,"padj":0.82744,"ES":0.58287,"NES":1.06415,"nMoreExtreme":25171,"size":787,"leadingEdge":["IL31RA","IDO1","CD74","LRRK2","CD38","LAMP3","NOD2","HLA-F","HGF","TNFSF10","ATP13A2","JAK2","PIM1","BCL2A1","RIPK2","FAS","ICAM1","KLF4","MUC1","FLT3LG","TNFSF18","PDCD1","IFIT3","ZC3H12A","JAK3","ATF5","IRF7","CARD16","TMEM109","EDN1","COMP","BCL6","CCL5","CSF1","NR4A3","IL7","SOD2","TNFAIP3","RNF144B","BIRC3","MYD88","IL6","FGF10","TXN","EGR3","NOTCH2","CHST11","TNF","SOX8","HPN","SERPINB9","RBCK1","CAMK1D","CCR5","ASCL1","CXCL12","NR4A2","LILRB1","SOCS3","CCL2","STAT3","ANGPTL4","NUAK2","GCLC","SRC","CCL19","CDKN1A","UCP2","UBE2Z","PTPN1","NFKBIA","IFI6","GRINA","MCL1","LIG4","PKHD1","SH3RF1","PTGS2","ADAMTS20","GAS6","ASNS","CX3CL1","FOXC1","PRELID1","CFLAR","TCIM","GATA3","BIRC7","NFE2L2","TNFRSF6B","SEMA4D","HERPUD1"]} {"pathway":"GO_REGULATION_OF_ATPASE_ACTIVITY","pval":0.36839,"padj":0.89036,"ES":0.67571,"NES":1.06401,"nMoreExtreme":27103,"size":66,"leadingEdge":["ATP1B2","PLSCR1","FGF10","SNX16","NAPA"]} {"pathway":"GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE","pval":0.39316,"padj":0.89503,"ES":0.72924,"NES":1.06401,"nMoreExtreme":26584,"size":38,"leadingEdge":["CD74","MUC1","CXCL12","KDM1A"]} {"pathway":"GO_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING","pval":0.35026,"padj":0.88512,"ES":0.63391,"NES":1.06387,"nMoreExtreme":28417,"size":122,"leadingEdge":["CEACAM1","HGF","JAK2","AGT","KLF4","BTN2A2","EDN1","NCF1","CCL5","LYN","NYAP2","TNF","FLT1","RASGRP1","PIK3AP1","SRC","PDGFRA","GATA3","NKX3-1","SEMA4D","PDGFB","PRR5L","PPP1R16B"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_VITAMIN_D","pval":0.47577,"padj":0.91085,"ES":0.81119,"NES":1.0637,"nMoreExtreme":29220,"size":19,"leadingEdge":["IL15","PIM1","CYP27B1","PTN"]} {"pathway":"GO_ESTABLISHMENT_OR_MAINTENANCE_OF_TRANSMEMBRANE_ELECTROCHEMICAL_GRADIENT","pval":0.63585,"padj":0.94878,"ES":0.8241,"NES":1.06368,"nMoreExtreme":35035,"size":8,"leadingEdge":["ATP1B2","SLC22A1","BAK1"]} {"pathway":"GO_RESPONSE_TO_FUNGUS","pval":0.43131,"padj":0.89981,"ES":0.77942,"NES":1.06363,"nMoreExtreme":27475,"size":25,"leadingEdge":["CLEC6A","TGFB1","BAK1","TLR4","BTK"]} {"pathway":"GO_NITRIC_OXIDE_MEDIATED_SIGNAL_TRANSDUCTION","pval":0.45004,"padj":0.90517,"ES":0.79431,"NES":1.06343,"nMoreExtreme":28159,"size":22,"leadingEdge":["AGT","MAFA","GUCY1A1","GUCY1B1","SPINK1","NOS2"]} {"pathway":"GO_CELL_CELL_SIGNALING","pval":0.20657,"padj":0.79637,"ES":0.58064,"NES":1.06333,"nMoreExtreme":20623,"size":1228,"leadingEdge":["PSME2","P2RX7","LRRK2","CXCL11","PSMB9","CD38","IL15","CXCL10","ADGRE5","CCL13","HGF","KREMEN1","TNFSF10","STX11","PSME1","CXCL9","EGR2","DKK2","GRIN3A","KCNJ10","HCAR2","JAK2","PSMB10","AGT","ERC2","CCL7","PSMB8","SIDT2","KLF4","CCL15","GRM8","TNFSF18","TSPAN32","PRRT2","SRI","CCL8","C3","RASGRF1","CMAHP","CYLD","P2RX4","RAPGEF2","MCTP2","EDN1","FAM107A","IL1RN","ANK2","COLQ","EXOC3L1","NAAA","CCL18","CCL5","LYN","DTNBP1","GLUL","TRABD2A","TNFAIP6","CADPS2","LTA","AKAP7","KCNE5","IL7","PTPRU","AMER1","TNFAIP3","CD70","RNF207","STAC3","IL6","FGF10","TXN","LTB","JPH4","EGR3","TNF","PSMA4","PSMA2","VGF","CUL1","SMPD3","CCR5","MOV10","SLC12A7","TCF7L1","CCL4","NR4A2","INSL4","GPR50","CCL2","MAFA","KMO","STAT3","TRIM9","RUNX1","SRC","VAX2","NTNG2","SYT5","CGAS","AKAP12","PSMA5","UCP2","NAMPT","GUCY1A1","IL17C","GABRR2","ADGRB1","PTGS2","CCL3","CX3CL1","GUCY1B1","GATA3","NKX3-1","PLCB1","GLS","SLC8A2","NADK","PDGFB","NAPA","SMAD3","STX3","SYT17"]} {"pathway":"GO_CORTICAL_CYTOSKELETON_ORGANIZATION","pval":0.387,"padj":0.89277,"ES":0.71537,"NES":1.06325,"nMoreExtreme":26647,"size":43,"leadingEdge":["PLEK","FMNL2","TNF","RHOQ","PAFAH1B1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION","pval":0.29934,"padj":0.85717,"ES":0.58896,"NES":1.06318,"nMoreExtreme":28624,"size":441,"leadingEdge":["GBP1","CD74","P2RX7","LRRK2","PLEK","BANK1","ATF3","OPTN","STAT1","BCL2A1","KLF4","MUC1","SRI","ZC3H12A","CYLD","BTN2A2","MIR503","HLA-G","BCL6","LITAF","LYN","TANK","SOD2","TNFAIP3","ARHGAP25","DUSP10","CXCL12","PTPRC","RHOH","SIK1B","PTPN2","DHX58","SRC","STMN3","DUSP5","PTPN1","GRINA","MCL1","PKHD1","LPAR1","PTGS2","RIPOR2","NFE2L2","SPINK1","HERPUD1","CLIC2","SLIT2","SIK1","MYOZ1","UBR1","HEG1","TLR4"]} {"pathway":"GO_REGULATION_OF_KIDNEY_DEVELOPMENT","pval":0.38254,"padj":0.89036,"ES":0.70533,"NES":1.06275,"nMoreExtreme":26699,"size":47,"leadingEdge":["STAT1","AGT","PRKX","SOX8","TGFB1","CFLAR","GATA3","LIN28A","PDGFB","HNF1B","SIX1"]} {"pathway":"GO_REGULATION_OF_PROTEIN_KINASE_A_SIGNALING","pval":0.52857,"padj":0.92669,"ES":0.83172,"NES":1.06263,"nMoreExtreme":31408,"size":15,"leadingEdge":["LRRK2","AKAP7","AKAP12","TCIM"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NEUROINFLAMMATORY_RESPONSE","pval":0.51353,"padj":0.92459,"ES":0.8271,"NES":1.06255,"nMoreExtreme":30761,"size":16,"leadingEdge":["LRRK2","STAP1","IL6","TNF","CCL3","IL33"]} {"pathway":"GO_CHRONIC_INFLAMMATORY_RESPONSE","pval":0.5288,"padj":0.92669,"ES":0.8315,"NES":1.06235,"nMoreExtreme":31422,"size":15,"leadingEdge":["IDO1","VCAM1","CCL5","LTA","TNFAIP3","TNF"]} {"pathway":"GO_REGULATION_OF_LEUKOCYTE_TETHERING_OR_ROLLING","pval":0.6044,"padj":0.94684,"ES":0.77227,"NES":1.06232,"nMoreExtreme":31980,"size":5,"leadingEdge":["CXCL12","PTAFR","ITGA4"]} {"pathway":"GO_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION","pval":0.18323,"padj":0.77986,"ES":0.57944,"NES":1.06183,"nMoreExtreme":18313,"size":1543,"leadingEdge":["TIFA","APOL3","UBD","CD40","GBP1","CD74","P2RX7","LRRK2","NOD2","CEACAM1","CCL13","PLEK","AMOT","HGF","TNFSF10","TAGAP","SECTM1","BANK1","ATF3","OPTN","STAT1","JAK2","AGT","BCL2A1","RIPK2","CCL7","FAS","CAMK2D","ICAM1","RMI2","KLF4","BCL2L11","CLEC6A","ARAP2","MUC1","CCL15","TGM2","CD80","TRIM22","PML","SRI","CCL8","SCIMP","S100A13","RASGRF1","ZC3H12A","CYLD","P2RX4","RAPGEF2","CARD16","NPR1","BTN2A2","EDN1","SLAMF1","NCF1","NRK","MIR503","PMAIP1","IL1RN","GADD45B","DDX60","GLIPR2","HLA-G","BCL6","CCL18","LITAF","CCL5","LYN","PYHIN1","DTNBP1","IFIT5","TLR7","TICAM2","CSF1","VRK2","TANK","AKAP7","SOD2","GAREM1","TNFAIP3","ARHGEF3","BIRC3","MYD88","CASP10","ARHGAP25","NRG4","IL6","TLR3","FGF10","TXN","JPH4","GADD45G","SEMA7A","NOTCH2","TNF","FLT1","RBCK1","DUSP10","CD86","GPR18","RASGRP1","F2RL2","PIK3AP1","CCL1","FARP2","FGD2","CXCL12","PTPRC","CHI3L1","RHOH","CCL4","AUTS2","FPR2","SIK1B","F3","CCL2","SH2B2","NBN","GUCA1A","P2RY12","PTPN2","DHX58","PAK1","NRG2","SRC","TGFB1","ARHGAP17","A2M","IQSEC3","ICOS","ROBO1","CCL19","CGAS","STMN3","AKAP12","PRDX1","PDGFRA","IKBKE","RRAGC","DUSP5","GUCY1A1","PTPN1","RHOQ","NFKBIA","GRINA","MCL1","PKHD1","SH3RF1","LPAR1","PLEKHF1","PTGS2","RIPOR2","SEZ6L","GAS6","CCL3","CX3CL1","TRIM25","CFLAR","TCIM","SLC44A2","RRAGD","GATA3","BIRC7","CASP1","NKX3-1","NFE2L2","LIN28A","SEMA4D","SPINK1","HERPUD1","DAPK2","PLCB1","CLIC2"]} {"pathway":"GO_CELLULAR_AMINO_ACID_CATABOLIC_PROCESS","pval":0.37583,"padj":0.89036,"ES":0.67959,"NES":1.06162,"nMoreExtreme":27372,"size":62,"leadingEdge":["IL4I1","SDSL","HPD","GLS","SDS","NOS2"]} {"pathway":"GO_AUTOPHAGOSOME_MATURATION","pval":0.40332,"padj":0.89503,"ES":0.74035,"NES":1.06138,"nMoreExtreme":26774,"size":34,"leadingEdge":["CALCOCO2","UVRAG","STX17","LAMP2"]} {"pathway":"GO_REGULATION_OF_PHOSPHATASE_ACTIVITY","pval":0.34661,"padj":0.88258,"ES":0.62177,"NES":1.06125,"nMoreExtreme":29038,"size":150,"leadingEdge":["PLEK","LMTK2","JAK2","TNF","PTPRC","ELFN1","PPARGC1B","SEMA4D","SMAD3","MYOZ1","PPP1R16B","PTN"]} {"pathway":"GO_POSITIVE_REGULATION_OF_T_HELPER_2_CELL_DIFFERENTIATION","pval":0.64214,"padj":0.94878,"ES":0.81122,"NES":1.06114,"nMoreExtreme":34903,"size":7,"leadingEdge":["CD86","PRKCZ"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SODIUM_ION_TRANSPORT","pval":0.5303,"padj":0.92803,"ES":0.83052,"NES":1.06111,"nMoreExtreme":31511,"size":15,"leadingEdge":["CAMK2D","NEDD4L"]} {"pathway":"GO_MEMBRANE_ORGANIZATION","pval":0.27343,"padj":0.83739,"ES":0.58181,"NES":1.06099,"nMoreExtreme":26967,"size":716,"leadingEdge":["TAP2","TAP1","P2RX7","STX11","SAMD9L","MYOF","ANO4","TAPBP","GLDN","SPTBN4","RTP4","BCL2L11","PRRT2","C3","ABCB1","STAP1","RAB20","GRAMD1B","IGF2R","PMAIP1","ANK2","S100A10","COLQ","DYSF","XKR6","CHMP4C","PLSCR4","NRCAM","PLSCR1","ARHGAP25","CTSZ","LPCAT2","FCHO1","TRIM72","AZIN2","CCR5","XKR8","PTPRC","MX1","VCPIP1","FCGR1A","STAT3","TRIM9","PARP11","UVRAG","CTSC","SAMD9","ADGRB1","GLTPD2","FNBP1","GAS6","XKR7","PRELID1","MITD1","BBC3","RILPL1","NAPA","STX3","RAB39A","SPTA1","STX17","BAK1","FCER1G","REEP4","SHISA7","FLOT1","ARC","RAPSN","NPC1"]} {"pathway":"GO_PROTEIN_HOMOTETRAMERIZATION","pval":0.37328,"padj":0.89036,"ES":0.66891,"NES":1.06063,"nMoreExtreme":27719,"size":70,"leadingEdge":["GBP5","DPYS","KCNJ2","SOD2","DECR1","ACTN2","ACPP","GLS"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION","pval":0.43126,"padj":0.89981,"ES":0.77238,"NES":1.06044,"nMoreExtreme":27592,"size":26,"leadingEdge":["HGF","MIR212","BAK1","MLXIPL"]} {"pathway":"GO_GLOMERULAR_EPITHELIAL_CELL_DEVELOPMENT","pval":0.64262,"padj":0.94878,"ES":0.81041,"NES":1.06007,"nMoreExtreme":34929,"size":7,"leadingEdge":["MYO1E","PODXL","JAG1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION","pval":0.41657,"padj":0.89503,"ES":0.75472,"NES":1.06001,"nMoreExtreme":27155,"size":30,"leadingEdge":["KLF4","MIR503","TGFB1","MIR212","TBXA2R"]} {"pathway":"GO_G_PROTEIN_COUPLED_PURINERGIC_NUCLEOTIDE_RECEPTOR_SIGNALING_PATHWAY","pval":0.58055,"padj":0.94163,"ES":0.83696,"NES":1.05986,"nMoreExtreme":33487,"size":12,"leadingEdge":["P2RY14","P2RY13","PTAFR","P2RY12","P2RY2","GPR171"]} {"pathway":"GO_REGULATION_OF_SENSORY_PERCEPTION","pval":0.45471,"padj":0.90517,"ES":0.79161,"NES":1.05982,"nMoreExtreme":28451,"size":22,"leadingEdge":["EDN1","PTAFR","CCL3","ACPP","MGLL"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INTERLEUKIN_2_PRODUCTION","pval":0.42345,"padj":0.89613,"ES":0.76255,"NES":1.05971,"nMoreExtreme":27353,"size":28,"leadingEdge":["PDE4B","RIPK2","CD80","CD83","IRF4","CD86","PTPRC","RUNX1","IL1A"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PROTEIN_BINDING","pval":0.36583,"padj":0.89036,"ES":0.65115,"NES":1.05967,"nMoreExtreme":28182,"size":89,"leadingEdge":["LRRK2","B2M","IFIT2","CARD16","XIRP1","RALB","DTNBP1","CTSZ","TEX14","MAP2","RIPOR2","MITD1","NKX3-1","PDGFB"]} {"pathway":"GO_IRON_IMPORT_INTO_CELL","pval":0.5547,"padj":0.93396,"ES":0.74413,"NES":1.05967,"nMoreExtreme":28869,"size":4,"leadingEdge":["HFE","PICALM","CUBN","SLC11A2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_DNA_METABOLIC_PROCESS","pval":0.37038,"padj":0.89036,"ES":0.6537,"NES":1.05909,"nMoreExtreme":28359,"size":85,"leadingEdge":["XRN1","RMI2","BCL6","PARP3","NBN","SRC","CGAS","HELB","STN1","GATA3"]} {"pathway":"GO_SYNCYTIUM_FORMATION","pval":0.39536,"padj":0.89503,"ES":0.71774,"NES":1.05905,"nMoreExtreme":27020,"size":41,"leadingEdge":["CXCL10","CXCL9","MYOF","FLT3LG","SBNO2","PLEKHO1","OCSTAMP","ADGRB1","RIPOR2","CFLAR","CD53","FLOT1","WNT1","DCSTAMP","EHD1"]} {"pathway":"GO_LYMPHOCYTE_MIGRATION","pval":0.3707,"padj":0.89036,"ES":0.6536,"NES":1.05893,"nMoreExtreme":28384,"size":85,"leadingEdge":["CXCL11","TBX21","CXCL10","CCL13","PADI2","CCL7","ICAM1","HSD3B7","CCL15","CCL8","CCL18","CCL5","TNFRSF14","CXCL16","CH25H","CCL1","CXCL12","CCL4","CCL2","ITGB7","CCL19","CCR6","RIPOR2","GAS6","CCL3","CX3CL1","GATA3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SUPRAMOLECULAR_FIBER_ORGANIZATION","pval":0.34782,"padj":0.8829,"ES":0.61195,"NES":1.05857,"nMoreExtreme":29926,"size":181,"leadingEdge":["PLEK","ICAM1","SCIN","EDN1","S100A10","PPM1E","CD47","ACTR3C","PAK1","CDC42EP2","ACTN2","LPAR1","CX3CL1","AP1AR","SMAD3","MET","PROX1","LIMK1"]} {"pathway":"GO_MUSCLE_CONTRACTION","pval":0.33647,"padj":0.8762,"ES":0.60021,"NES":1.0584,"nMoreExtreme":30274,"size":251,"leadingEdge":["CD38","PDE4B","SSTR2","AGT","MYOF","KCNJ2","CAMK2D","SRI","ZC3H12A","P2RX4","EDN1","ANK2","COMP","DYSF","TIFAB","SSPN","KCNE5","MYH7","RNF207","STAC3","SLC8A1","DES","TRIM72","PTAFR","KCNE1","KCNMA1","GUCY1A1","ACTN2","PTGS2","CLIC2","RCSD1","KCNE1B","EDNRA","ARHGEF11"]} {"pathway":"GO_SYNAPTIC_VESICLE_CYCLE","pval":0.35271,"padj":0.888,"ES":0.61926,"NES":1.05838,"nMoreExtreme":29622,"size":153,"leadingEdge":["P2RX7","LRRK2","STX11","GRIN3A","ERC2","PRRT2","SLC18A1","DTNBP1","CADPS2","TRIM9","SYT5","NAPA","STX3","SYT17"]} {"pathway":"GO_PROTEIN_LIPID_COMPLEX_ASSEMBLY","pval":0.45683,"padj":0.90517,"ES":0.79017,"NES":1.05789,"nMoreExtreme":28584,"size":22,"leadingEdge":["SOAT1","ABCA7"]} {"pathway":"GO_DNA_MODIFICATION","pval":0.36993,"padj":0.89036,"ES":0.65071,"NES":1.05772,"nMoreExtreme":28451,"size":88,"leadingEdge":["APOBEC3D","APOBEC3A","APOBEC3G","PIWIL4","TDRD9","PARP3","APOBEC3F","OTUD4","GATA3","KDM1B"]} {"pathway":"GO_REGULATION_OF_WOUND_HEALING","pval":0.36721,"padj":0.89036,"ES":0.64468,"NES":1.05771,"nMoreExtreme":28652,"size":96,"leadingEdge":["SERPING1","CEACAM1","PLEK","ENPP4","EDN1","LYN","TNFAIP3","DUSP10","F3","CDKN1A","GP1BA","PDGFRA","NFE2L2","PDGFB","SMAD3","MYOZ1","FCER1G","TLR4"]} {"pathway":"GO_AXIS_ELONGATION","pval":0.4302,"padj":0.89981,"ES":0.7657,"NES":1.05767,"nMoreExtreme":27661,"size":27,"leadingEdge":["FGF10","TGFB1","HNF1B","SIX1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NIK_NF_KAPPAB_SIGNALING","pval":0.37919,"padj":0.89036,"ES":0.66936,"NES":1.05758,"nMoreExtreme":28018,"size":68,"leadingEdge":["NOD2","EDN1","TLR7","TLR3","TNF","RBCK1","CHI3L1","CCL19","TCIM","TLR4"]} {"pathway":"GO_REGULATION_OF_JUN_KINASE_ACTIVITY","pval":0.37622,"padj":0.89036,"ES":0.65757,"NES":1.05726,"nMoreExtreme":28483,"size":79,"leadingEdge":["RIPK2","EDN1","NRK","DTNBP1","TNF","DUSP10","FGD2","PAK1","CCL19","PTPN1","BIRC7"]} {"pathway":"GO_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL","pval":0.3833,"padj":0.89036,"ES":0.67513,"NES":1.05672,"nMoreExtreme":27995,"size":63,"leadingEdge":["CXCL11","CXCL10","CXCL9","CAMK2D","SRI","ANK2","LYN","JPH4","SLC8A1","TGFB1","CX3CL1","CLIC2"]} {"pathway":"GO_DRUG_CATABOLIC_PROCESS","pval":0.38402,"padj":0.89083,"ES":0.67644,"NES":1.0567,"nMoreExtreme":27968,"size":62,"leadingEdge":["DPYS","COLQ","SDSL","PRDX1","ADA2","SDS"]} {"pathway":"GO_ANTIBIOTIC_METABOLIC_PROCESS","pval":0.38928,"padj":0.89426,"ES":0.69538,"NES":1.05638,"nMoreExtreme":27381,"size":50,"leadingEdge":["CYP1A1","CTNS","STAT3","ACSS1","PRDX1","ALDH3B1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SIGNALING","pval":0.24559,"padj":0.82387,"ES":0.57704,"NES":1.05625,"nMoreExtreme":24488,"size":1113,"leadingEdge":["PSME2","GBP1","CD74","P2RX7","SOCS1","LRRK2","PSMB9","CD38","CEACAM1","PLEK","HGF","KREMEN1","NLRC5","TNFSF10","PSME1","ACOD1","BANK1","CHRD","DKK2","ATF3","PADI2","OPTN","STAT1","PSMB10","AGT","BCL2A1","ONECUT2","FAS","PSMB8","ICAM1","KLF4","MUC1","SRI","CD300LF","ZC3H12A","CYLD","STAP1","CARD16","BTN2A2","EDN1","SLAMF1","MIR503","CISH","MVP","LILRA2","IL1RN","HLA-G","BCL6","LITAF","CCL5","LYN","CHAC1","TRABD2A","PARP14","TICAM2","TANK","IL7","SOD2","PTPRU","AMER1","IRF4","TNFAIP3","LILRA4","ARHGAP25","IL6","TLR3","LILRB4","FGF10","HTRA4","CHST11","TNF","FST","PSMA4","PSMA2","DUSP10","TRIM72","CD47","RGS7BP","NTN1","CXCL12","PTPRC","RHOH","NR1H3","NR4A2","SIK1B","SOCS3","PTPN2","DHX58","GCLC","SRC","TGFB1","ROBO1","STMN3","CXCL8","PSMA5","UCP2","DUSP5","PTPN1","NFKBIA","IFI6","GRINA","MCL1","PKHD1","SH3RF1","LPAR1","OTUD4","CREBRF","PTGS2","RIPOR2","GAS6","RGS1","CX3CL1","PRELID1","AP1AR","CFLAR","RGS9","TCIM","GATA3","NKX3-1","NFE2L2","SPINK1","HERPUD1","CLIC2","IL1R2","SMAD3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INTERLEUKIN_5_PRODUCTION","pval":0.60189,"padj":0.94684,"ES":0.83396,"NES":1.05606,"nMoreExtreme":34367,"size":11,"leadingEdge":["GATA3","IL33","PRKCZ"]} {"pathway":"GO_NEUROTRANSMITTER_BIOSYNTHETIC_PROCESS","pval":0.3833,"padj":0.89036,"ES":0.66675,"NES":1.05502,"nMoreExtreme":28370,"size":69,"leadingEdge":["GCH1","JAK2","AGT","ICAM1","KLF4","ZC3H12A","P2RX4","EDN1","TNF","CD47","SLC7A2","PTGS2","MIR212","SMAD3","TLR4","ASS1"]} {"pathway":"GO_RESPONSE_TO_HERBICIDE","pval":0.64019,"padj":0.94878,"ES":0.81725,"NES":1.05484,"nMoreExtreme":35274,"size":8,"leadingEdge":["CYP1A1","ZC3H12A","HTRA2"]} {"pathway":"GO_DRUG_METABOLIC_PROCESS","pval":0.3486,"padj":0.88316,"ES":0.60141,"NES":1.05476,"nMoreExtreme":30930,"size":227,"leadingEdge":["DPYS","CYP1A1","SQOR","MTHFD2","NPR1","DHRS9","COLQ","CTNS","MYH7","SDSL","CBR1","TCN2","SLC25A25","NR4A2","STAT3","ACSS1","PRDX1","ATP6V1A","ADA2","MMAA","AMN","ACPP","CKB","AK4","NADK","RFK"]} {"pathway":"GO_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION","pval":0.36146,"padj":0.89036,"ES":0.6197,"NES":1.05464,"nMoreExtreme":30096,"size":145,"leadingEdge":["PSME2","PSMB9","PLEK","PSME1","PSMB10","PSMB8","FST","PSMA4","PSMA2","SMPD3","PTPRC","RUNX1","TGFB1","PSMA5","PDGFRA","LIG4","FOXC1","GATA3","NFE2L2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS","pval":0.39835,"padj":0.89503,"ES":0.70436,"NES":1.05456,"nMoreExtreme":27655,"size":45,"leadingEdge":["IDO1","CD74","NOD2","JAK3","IRF7","BCL6","CCL5","CCR5","CXCL12","LILRB1","CCL19","GAS6"]} {"pathway":"GO_RESPONSE_TO_FLUID_SHEAR_STRESS","pval":0.41607,"padj":0.89503,"ES":0.7391,"NES":1.05455,"nMoreExtreme":27503,"size":33,"leadingEdge":["P2RX7","KLF4","P2RX4","SRC","TGFB1","PTGS2","HAS2","NFE2L2","ASS1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INTERLEUKIN_8_PRODUCTION","pval":0.40911,"padj":0.89503,"ES":0.72583,"NES":1.05455,"nMoreExtreme":27520,"size":37,"leadingEdge":["NOD2","TLR8","TLR7","MYD88","TLR3","TNF","DDX58","TLR4","CD244","TLR1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORT","pval":0.61987,"padj":0.94878,"ES":0.83053,"NES":1.05438,"nMoreExtreme":34988,"size":10,"leadingEdge":["CAMK2D","NEDD4L"]} {"pathway":"GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_RENIN_ANGIOTENSIN","pval":0.49834,"padj":0.91907,"ES":0.80953,"NES":1.05429,"nMoreExtreme":30319,"size":18,"leadingEdge":["SUCNR1","AGT","CTSZ","CES1","ENPEP"]} {"pathway":"GO_PLATELET_DEGRANULATION","pval":0.37334,"padj":0.89036,"ES":0.63671,"NES":1.0542,"nMoreExtreme":29611,"size":105,"leadingEdge":["SERPING1","PLEK","HGF","LGALS3BP","SCG3","VEGFC","LYN","TUBA4A","TGFB1","A2M","ACTN2","GAS6","ENDOD1","PDGFB","FCER1G"]} {"pathway":"GO_POSITIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT","pval":0.36089,"padj":0.89036,"ES":0.615,"NES":1.05386,"nMoreExtreme":30479,"size":158,"leadingEdge":["CD40","CEACAM1","HGF","KLF4","C3","ZC3H12A","RAPGEF2","VEGFC","MIR503","SOD2","ANXA3","TLR3","FLT1","ADM2","CHI3L1","F3","STAT3","ANGPTL4","RUNX1","CXCL8","PTGS2","CX3CL1","CFLAR","NFE2L2","ERAP1","PDGFB","IL1A","PPP1R16B","S100A1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_NEURON_DEATH","pval":0.48758,"padj":0.91689,"ES":0.80356,"NES":1.05368,"nMoreExtreme":29945,"size":19,"leadingEdge":["NR4A3","WNT1"]} {"pathway":"GO_ACTIVATION_OF_JUN_KINASE_ACTIVITY","pval":0.41226,"padj":0.89503,"ES":0.72811,"NES":1.05341,"nMoreExtreme":27616,"size":36,"leadingEdge":["RIPK2","CCL19","PTPN1","BIRC7","MLKL"]} {"pathway":"GO_L_GLUTAMATE_IMPORT","pval":0.58653,"padj":0.94167,"ES":0.83167,"NES":1.05316,"nMoreExtreme":33832,"size":12,"leadingEdge":["KCNJ10","SLC1A3"]} {"pathway":"GO_ALCOHOL_CATABOLIC_PROCESS","pval":0.4047,"padj":0.89503,"ES":0.71356,"NES":1.05288,"nMoreExtreme":27658,"size":41,"leadingEdge":["GK","HSD3B7","SCARF1","GPD2","MTMR7"]} {"pathway":"GO_REGULATION_OF_INTESTINAL_ABSORPTION","pval":0.43771,"padj":0.90126,"ES":0.70585,"NES":1.05282,"nMoreExtreme":21995,"size":2,"leadingEdge":["HAMP","APOA1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_BINDING","pval":0.38123,"padj":0.89036,"ES":0.6476,"NES":1.05173,"nMoreExtreme":29295,"size":87,"leadingEdge":["LRRK2","RIPK2","B2M","RAPGEF2","RALB","DTX3L","HERPUD1","SPTA1","FLOT1"]} {"pathway":"GO_MEMBRANE_LIPID_METABOLIC_PROCESS","pval":0.3647,"padj":0.89036,"ES":0.61061,"NES":1.05171,"nMoreExtreme":31112,"size":170,"leadingEdge":["P2RX7","B4GALT5","TNF","SMPD3","ST3GAL5","ELOVL7","GM2A","PLPP1","PIGY","KDSR"]} {"pathway":"GO_REGULATION_OF_ACTION_POTENTIAL","pval":0.41174,"padj":0.89503,"ES":0.72074,"NES":1.0516,"nMoreExtreme":27840,"size":38,"leadingEdge":["KCNJ2","CAMK2D","ANK2","RNF207","GPR35"]} {"pathway":"GO_SECOND_MESSENGER_MEDIATED_SIGNALING","pval":0.34698,"padj":0.88271,"ES":0.59072,"NES":1.05159,"nMoreExtreme":31968,"size":304,"leadingEdge":["GBP1","P2RX7","LRRK2","CXCL11","CXCL10","ADGRE5","PLEK","RXFP1","CXCL9","AGT","CAMK2D","VCAM1","SRI","CCRL2","P2RX4","RAPGEF2","MCTP2","NPR1","EDN1","ANK2","ADGRG5","PTGER4","JPH4","TNF","PTGER2","SLC8A1","ADM2","CCR5","PTPRC","CCL4","FPR2","ACKR4","MAFA","GUCA1A","P2RY12","CGAS","CCR6","CXCL8","GUCY1A1","ADGRB1","LPAR1","CCL3","GUCY1B1","SPINK1","CLIC2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS","pval":0.54057,"padj":0.92889,"ES":0.82304,"NES":1.05155,"nMoreExtreme":32121,"size":15,"leadingEdge":["IDO1","P2RX7","CD274","PDCD1","CCL5","PRELID1"]} {"pathway":"GO_INOSITOL_LIPID_MEDIATED_SIGNALING","pval":0.36763,"padj":0.89036,"ES":0.6148,"NES":1.05132,"nMoreExtreme":30921,"size":154,"leadingEdge":["CEACAM1","HGF","JAK2","AGT","KLF4","BTN2A2","EDN1","NCF1","CCL5","LYN","NYAP2","TNF","FLT1","RASGRP1","PIK3AP1","PTAFR","SRC","PDGFRA","GATA3","NKX3-1","SEMA4D","PLCB1","PDGFB","PRR5L","NGF","PPP1R16B"]} {"pathway":"GO_RENAL_FILTRATION","pval":0.54068,"padj":0.92889,"ES":0.82284,"NES":1.0513,"nMoreExtreme":32128,"size":15,"leadingEdge":["MYO1E","GAS6","PDGFB","ITGA3"]} {"pathway":"GO_REGULATION_OF_CHEMOTAXIS","pval":0.36474,"padj":0.89036,"ES":0.60933,"NES":1.05126,"nMoreExtreme":31201,"size":175,"leadingEdge":["CD74","CXCL10","PADI2","SUCNR1","CCL7","P2RX4","STAP1","EDN1","VEGFC","DYSF","SLAMF8","CCL5","LYN","IL12A","CSF1","IL6","FGF10","SEMA7A","GPR18","CAMK1D","CCL1","CXCL12","CCL4","FPR2","F3","CCL2","P2RY12","PTPN2","TGFB1","SEMA4A","ROBO1","CCL19","CCR6","CXCL8","PDGFRA","LPAR1","RIPOR2","GAS6","CCL3","SEMA4D","DAPK2","PDGFB","SMAD3","STX3","SLIT2"]} {"pathway":"GO_REGULATION_OF_CELL_DIFFERENTIATION","pval":0.2374,"padj":0.82177,"ES":0.57365,"NES":1.05108,"nMoreExtreme":23721,"size":1458,"leadingEdge":["IRF1","PSME2","ASCL2","GBP1","CD74","HLA-DOA","SOCS1","LRRK2","IL12RB1","PSMB9","CD38","IL15","TBX21","CXCL10","CEACAM1","HGF","KREMEN1","PSME1","CXCL9","CHRD","STAT1","CTLA4","JAK2","PSMB10","AGT","TMEM176A","TMEM176B","RIPK2","BHLHE41","IL27","PSMB8","KLF4","SCARF1","LILRB3","IFITM1","FLT3LG","CD80","B2M","ZC3H12A","JAK3","CYLD","P2RX4","RAPGEF2","STAP1","SCIN","IRF7","BTN2A2","EDN1","VEGFC","MAFF","C21orf91","S100A10","GLIPR2","HLA-G","SLAMF8","DYNLT1","BCL6","LYN","CSF1","LTA","NR4A3","IL7","CTSL","NRCAM","SOD2","PRKX","CD83","IRF4","CTSZ","IL6","TLR3","LILRB4","FGF10","EGR3","TBX19","SEMA7A","NOTCH2","TNF","SOX8","PSMA4","PSMA2","HPN","DUSP10","CD86","HOPX","TRIM72","RASGRP1","CAMK1D","MOV10","NCOA1","ASCL1","NTN1","CXCL12","CYP27B1","PTPRC","NR1H3","LILRB1","SOCS3","STAT3","P2RY12","PTPN2","PAK1","TGIF2","RUNX1","TGFB1","SEMA4A","OCSTAMP","ROBO1","IL2RA","CCL19","C1QC","PSMA5","GP1BA","PDGFRA","CDKN1C","ISL2","SORT1","NFKBIA","MAP2","RGMA","ADGRB1","LIG4","ISG15","SH3RF1","LPAR1","PTGS2","RIPOR2","ADAMTS20","HAS2","GAS6","CCL3","CX3CL1","FOXC1","PRELID1","AP1AR","CFLAR","GATA3","NFE2L2","SRCIN1","PPARGC1B","LIN28A","SEMA4D","CD53","PLCB1","PDGFB","SMAD3","SYT17","DENND5A","ZFP36","SLIT2","SIK1","NFAM1","RORB","BOC","TRIM46","HLX","NGF","ESRRB"]} {"pathway":"GO_INTERLEUKIN_4_SECRETION","pval":0.60651,"padj":0.94703,"ES":0.76402,"NES":1.05097,"nMoreExtreme":32092,"size":5,"leadingEdge":["GATA3","NOTCH1"]} {"pathway":"GO_TISSUE_REGENERATION","pval":0.40543,"padj":0.89503,"ES":0.70432,"NES":1.05084,"nMoreExtreme":28050,"size":44,"leadingEdge":["DYSF","FGF10","DUSP10","CDKN1A","CFLAR","MYOZ1","SOX2","IFRD1"]} {"pathway":"GO_RESPONSE_TO_PEPTIDE","pval":0.34004,"padj":0.87818,"ES":0.58383,"NES":1.05071,"nMoreExtreme":32242,"size":398,"leadingEdge":["CD40","SOCS1","NOD2","CEACAM1","TNFSF10","EGR2","STAT1","JAK2","AGT","RIPK2","VCAM1","ICAM1","KLF4","JAK3","CASP4","EDN1","CISH","LYN","NR4A3","TNFAIP3","STAT5A","VGF","TRIM72","SMPD3","CXCL12","NR4A2","FPR2","SOCS3","SH2B2","STAT3","PTPN2","PAK1","GCLC","SRC","TGFB1","UCP2","ATP6V1A","NAMPT","PTPN1","RHOQ","SORT1","NFKBIA","ACTN2","PTGS2","IRF5","CFLAR","AGTRAP","NFE2L2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY","pval":0.55641,"padj":0.93517,"ES":0.82559,"NES":1.05065,"nMoreExtreme":32750,"size":14,"leadingEdge":["ATP1B2","ANK2","RNF207","ACTN2"]} {"pathway":"GO_MAMMARY_GLAND_MORPHOGENESIS","pval":0.41138,"padj":0.89503,"ES":0.71687,"NES":1.05058,"nMoreExtreme":27941,"size":39,"leadingEdge":["PML","CSF1","FGF10","NTN1","SRC","TGFB1","CAPN1"]} {"pathway":"GO_REGULATION_OF_DEPHOSPHORYLATION","pval":0.36642,"padj":0.89036,"ES":0.60739,"NES":1.0503,"nMoreExtreme":31503,"size":180,"leadingEdge":["PLEK","LMTK2","JAK2","TNF","PTPRC","TGFB1","ELFN1","PPARGC1B","SEMA4D","SMAD3","MYOZ1","PPP1R16B","PTN","LILRB2","EIF2AK2"]} {"pathway":"GO_REGULATION_OF_STEM_CELL_DIFFERENTIATION","pval":0.38019,"padj":0.89036,"ES":0.63718,"NES":1.05011,"nMoreExtreme":29911,"size":100,"leadingEdge":["PSME2","PSMB9","PSME1","PSMB10","PSMB8","PSMA4","PSMA2","STAT3","RUNX1","PSMA5","PDGFRA","FOXC1","GATA3","NFE2L2"]} {"pathway":"GO_GLYCEROLIPID_BIOSYNTHETIC_PROCESS","pval":0.36569,"padj":0.89036,"ES":0.60386,"NES":1.04994,"nMoreExtreme":31799,"size":196,"leadingEdge":["GK","ACSL1","C3","PCYT1A","DGAT2","CDS1","PLSCR1","LPCAT2","PLA2G4A","NR1H3","FPR2","AGPAT3","MFSD2A","SLC44A2","PDGFB","RAB38","SIK1","PIGY","AGAP2","MTMR8"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS","pval":0.25423,"padj":0.82744,"ES":0.57313,"NES":1.04983,"nMoreExtreme":25393,"size":1327,"leadingEdge":["PSME2","GBP1","CD74","P2RX7","SOCS1","LRRK2","PSMB9","SERPING1","TBX21","HLA-F","CEACAM1","PLEK","HGF","KREMEN1","NLRC5","TNFSF10","PSME1","HLA-E","ACOD1","BANK1","CHRD","DKK2","ATF3","NMI","PADI2","OPTN","STAT1","GRIN3A","PSMB10","AGT","TRAFD1","BCL2A1","ONECUT2","FAS","PSMB8","ICAM1","RMI2","KLF4","MUC1","SRI","CD300LF","MEFV","ZC3H12A","JAK3","CYLD","STAP1","CARD16","BTN2A2","EDN1","SLAMF1","MIR503","CISH","LILRA2","IL1RN","HLA-G","SLAMF8","PTGER4","BCL6","LITAF","CCL5","LYN","CHAC1","TRABD2A","TNFAIP6","PARP14","TICAM2","NR4A3","TNFRSF14","TANK","PARP3","IL7","SOD2","PTPRU","AMER1","IRF4","TNFAIP3","LILRA4","ARHGAP25","IL6","TLR3","LILRB4","FGF10","TXN","HTRA4","SEMA7A","CHST11","TNF","FST","PSMA4","PSMA2","SERPINB9","DUSP10","TRIM72","GPR18","CD47","RGS7BP","NTN1","CXCL12","PTPRC","RHOH","NR1H3","NR4A2","LILRB1","SIK1B","SOCS3","CCL2","PTPN2","DHX58","GCLC","SRC","TGFB1","SEMA4A","A2M","ROBO1","IL2RA","CGAS","STMN3","CXCL8","CDKN1A","PSMA5","GP1BA","UCP2","PDGFRA","NAMPT","DUSP5","HELB","PTPN1","NFKBIA","RGMA","IFI6","GRINA","MCL1","PKHD1","SH3RF1","LPAR1","OTUD4","CREBRF","PTGS2","RIPOR2","GAS6","RGS1","CX3CL1","PRELID1","CFLAR","RGS9","TCIM","GATA3","NKX3-1","NFE2L2","IL33","SEMA4D","SPINK1","HERPUD1","CLIC2","IL1R2","PDGFB","SMAD3"]} {"pathway":"GO_STEROID_CATABOLIC_PROCESS","pval":0.4674,"padj":0.90738,"ES":0.78414,"NES":1.04981,"nMoreExtreme":29245,"size":22,"leadingEdge":["HSD3B7","SCARF1","CYP27B1","HSD17B6"]} {"pathway":"GO_METANEPHRIC_LOOP_OF_HENLE_DEVELOPMENT","pval":0.4392,"padj":0.90126,"ES":0.70366,"NES":1.04955,"nMoreExtreme":22070,"size":2,"leadingEdge":["PKD1","PKD2"]} {"pathway":"GO_MAMMARY_GLAND_FORMATION","pval":0.63501,"padj":0.94878,"ES":0.78475,"NES":1.04935,"nMoreExtreme":34080,"size":6,"leadingEdge":["FGF10","FGFR2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PHOSPHORYLATION","pval":0.34899,"padj":0.88316,"ES":0.58345,"NES":1.04847,"nMoreExtreme":32966,"size":381,"leadingEdge":["GBP1","P2RX7","SOCS1","LRRK2","CEACAM1","HGF","ATF3","KLF4","ZC3H12A","CYLD","STAP1","BTN2A2","MIR503","MVP","GADD45B","PPM1E","LYN","DTNBP1","PARP14","TNFAIP3","DUSP10","PTPRC","RHOH","SOCS3","PTPN2","TGFB1","CDKN1A","ADAR","DUSP5","CDKN1C","PTPN1","SRCIN1","MIR212","SEMA4D","SPINK1","SLIT2","BAK1","PRR5L","C9orf72","HEG1","TLR4"]} {"pathway":"GO_POSTTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE_TRANSLOCATION","pval":0.60714,"padj":0.94703,"ES":0.7622,"NES":1.04847,"nMoreExtreme":32125,"size":5,"leadingEdge":["SEC62","SEC63","HSPA5","SEC61A1","SEC61B"]} {"pathway":"GO_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS","pval":0.35331,"padj":0.888,"ES":0.58545,"NES":1.04821,"nMoreExtreme":33068,"size":346,"leadingEdge":["IDO1","CD74","CEACAM1","ACOD1","ACSL1","CYP1A1","HSD3B7","OSBPL6","C3","ACOT4","EDN1","DGAT2","GGT5","NR4A3","KYNU","SLC27A3","PLA2G4C","DECR1","CBR1","CH25H","PLA2G4A","ACSL5","NR1H3","ELOVL7","KMO","LDHAL6B","ACSS1","PTGS2","ACSM5","CES1","ERLIN1"]} {"pathway":"GO_REGULATION_OF_INTEGRIN_ACTIVATION","pval":0.63705,"padj":0.94878,"ES":0.82061,"NES":1.04817,"nMoreExtreme":35600,"size":9,"leadingEdge":["PLEK","PTGER4","FARP2","P2RY12","SRC"]} {"pathway":"GO_REGULATION_OF_HYDROGEN_PEROXIDE_BIOSYNTHETIC_PROCESS","pval":0.60719,"padj":0.94703,"ES":0.76191,"NES":1.04807,"nMoreExtreme":32128,"size":5,"leadingEdge":["CTNS","STAT3","FYN"]} {"pathway":"GO_REGULATION_OF_CARDIAC_CONDUCTION","pval":0.40321,"padj":0.89503,"ES":0.6899,"NES":1.04805,"nMoreExtreme":28361,"size":50,"leadingEdge":["ATP1B2","AGT","CAMK2D","SRI","NPR1","ANK2","RNF207","SLC8A1","SLC8A2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY","pval":0.38572,"padj":0.89183,"ES":0.64324,"NES":1.04804,"nMoreExtreme":29772,"size":90,"leadingEdge":["HGF","TNFSF10","FAS","ICAM1","IL7","TNFAIP3","FGF10","TNF","GCLC","SRC","IFI6","MCL1","SH3RF1","CX3CL1","CFLAR","IL1A"]} {"pathway":"GO_POSITIVE_REGULATION_OF_EPIDERMIS_DEVELOPMENT","pval":0.4482,"padj":0.90517,"ES":0.76336,"NES":1.04804,"nMoreExtreme":28676,"size":26,"leadingEdge":["TNF","FST","CYP27B1","FOXC1","PRKCH"]} {"pathway":"GO_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_POTENTIAL","pval":0.3979,"padj":0.89503,"ES":0.66814,"NES":1.04784,"nMoreExtreme":29138,"size":64,"leadingEdge":["P2RX7","LRRK2","PMAIP1","CTNS","GCLC","SRC","UCP2","IFI6","PRELID1","BAK1"]} {"pathway":"GO_RESPONSE_TO_WOUNDING","pval":0.33802,"padj":0.87818,"ES":0.57854,"NES":1.04782,"nMoreExtreme":32645,"size":503,"leadingEdge":["IRF1","CD40","P2RX7","SERPING1","CEACAM1","PLEK","KREMEN1","JAK2","MYOF","CYP1A1","KLF4","SCARF1","ENPP4","TSPAN32","P2RX4","EDN1","MAFF","COMP","DYSF","LYN","DTNBP1","PLSCR1","TNFAIP3","IL6","FGF10","PROCR","DGKG","DUSP10","TRIM72","F2RL2","LCP2","F3","SH2B2","P2RY12","PAK1","SRC","TGFB1","A2M","CDKN1A","GP1BA","PDGFRA","RGMA","GAS6","CX3CL1","CFLAR","GATA3","IRF2","NFE2L2","PDGFB","SMAD3","ZFP36","IL1A","MYOZ1","FCER1G"]} {"pathway":"GO_PEPTIDYL_LYSINE_ACETYLATION","pval":0.37564,"padj":0.89036,"ES":0.61345,"NES":1.04744,"nMoreExtreme":31483,"size":151,"leadingEdge":["MUC1","JADE2","BAZ1A","IRF4","NCOA1","AUTS2","TGFB1","GATA3","GTF2B"]} {"pathway":"GO_GASTRULATION_WITH_MOUTH_FORMING_SECOND","pval":0.47016,"padj":0.9079,"ES":0.78233,"NES":1.04739,"nMoreExtreme":29418,"size":22,"leadingEdge":["AMOT","CHRD","LRP6"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_KETONE","pval":0.39581,"padj":0.89503,"ES":0.65517,"NES":1.04723,"nMoreExtreme":29721,"size":75,"leadingEdge":["ACOD1","XRN1","ICAM1","KLF4","PTGER4","PTGER2","SRC","TGFB1","CFLAR","ASS1"]} {"pathway":"GO_NEUROTROPHIN_TRK_RECEPTOR_SIGNALING_PATHWAY","pval":0.43531,"padj":0.90091,"ES":0.74534,"NES":1.04684,"nMoreExtreme":28377,"size":30,"leadingEdge":["AGT","SRC","SORT1","NGF","HAP1"]} {"pathway":"GO_HEPATICOBILIARY_SYSTEM_DEVELOPMENT","pval":0.38465,"padj":0.89083,"ES":0.62352,"NES":1.04645,"nMoreExtreme":31207,"size":122,"leadingEdge":["CEACAM1","HGF","ONECUT2","CYP1A1","DNAAF1","IGF2R","EPHX1","TNFAIP3","HPN","TGFB1","UCP2","ASNS","CFLAR","AK4","SMAD3","HLX","ARID5B","ASS1","ALDH1A2","COBL","MET","PROX1","LSR","PTN","WNT1","HNF1B"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_NEUROTRANSMITTER_UPTAKE","pval":0.636,"padj":0.94878,"ES":0.78227,"NES":1.04604,"nMoreExtreme":34133,"size":6,"leadingEdge":["GPM6B","NOS1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS","pval":0.32607,"padj":0.87041,"ES":0.57352,"NES":1.04598,"nMoreExtreme":32166,"size":727,"leadingEdge":["IRF1","ASCL2","GBP1","CD74","SOCS1","LRRK2","CD38","TBX21","CXCL10","CEACAM1","AMOT","KREMEN1","CHRD","STAT1","CTLA4","AGT","TMEM176A","TMEM176B","BHLHE41","KLF4","LILRB3","PDCD1","PML","B2M","ZC3H12A","JAK3","RAPGEF2","STAP1","NPR1","MIR503","HLA-G","DYNLT1","BCL6","LYN","PARP3","CTSZ","IL6","TLR3","LILRB4","FGF10","SEMA7A","TNF","SOX8","HPN","DUSP10","HOPX","TRIM72","ASCL1","NTN1","NR1H3","LILRB1","STAT3","P2RY12","PTPN2","PAK1","RUNX1","TGFB1","SEMA4A","ROBO1","C1QC","CDKN1A","NAMPT","ISL2","SORT1","NFKBIA","MAP2","RGMA","ADGRB1","LPAR1","GAS6","CCL3","CX3CL1","FOXC1","AP1AR","CFLAR","GATA3","NKX3-1","NFE2L2","LIN28A","MIR212","SEMA4D","PDGFB","SMAD3","DENND5A","ZFP36","SLIT2","MYOZ1","RORB","TRIM46","HLX","ESRRB"]} {"pathway":"GO_POSITIVE_REGULATION_OF_BINDING","pval":0.37886,"padj":0.89036,"ES":0.60887,"NES":1.0454,"nMoreExtreme":32110,"size":163,"leadingEdge":["LRRK2","JAK2","RIPK2","KLF4","B2M","RAPGEF2","RALB","DTX3L","S100A10","PYHIN1","PARP9","IRF4","TXN","TGFB1","RIPOR2","FOXC1","GATA3","HERPUD1","CLIC2","SPTA1","NGF","FLOT1","GTF2B"]} {"pathway":"GO_MESODERM_DEVELOPMENT","pval":0.39048,"padj":0.89495,"ES":0.63713,"NES":1.04532,"nMoreExtreme":30468,"size":96,"leadingEdge":["SECTM1","CHRD","JAK2","OVOL1","KLF4","NR4A3","FOXC1","SMAD3"]} {"pathway":"GO_NEUTRAL_LIPID_BIOSYNTHETIC_PROCESS","pval":0.43771,"padj":0.90126,"ES":0.74418,"NES":1.0452,"nMoreExtreme":28533,"size":30,"leadingEdge":["GK","ACSL1","C3","DGAT2","NR1H3","SIK1"]} {"pathway":"GO_OLFACTORY_LOBE_DEVELOPMENT","pval":0.47301,"padj":0.90882,"ES":0.78058,"NES":1.04505,"nMoreExtreme":29596,"size":22,"leadingEdge":["LRRK2","ATF5","SEMA7A","ROBO1","SLIT2"]} {"pathway":"GO_RESPONSE_TO_CATECHOLAMINE","pval":0.43455,"padj":0.90066,"ES":0.74032,"NES":1.04504,"nMoreExtreme":28447,"size":31,"leadingEdge":["LRRK2","PDE4B","NR4A3","KCNQ1"]} {"pathway":"GO_AMYLOID_PRECURSOR_PROTEIN_METABOLIC_PROCESS","pval":0.4092,"padj":0.89503,"ES":0.68762,"NES":1.04459,"nMoreExtreme":28782,"size":50,"leadingEdge":["GSAP","SOAT1","LYN","PSEN2","HAP1"]} {"pathway":"GO_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION","pval":0.37363,"padj":0.89036,"ES":0.59364,"NES":1.04435,"nMoreExtreme":33413,"size":240,"leadingEdge":["P2RX7","CXCL11","CD38","CXCL10","CXCL9","JAK2","AGT","MCOLN2","CAMK2D","TGM2","PML","SRI","CCRL2","P2RX4","EDN1","ANK2","PTGER4","LYN","JPH4","PTGER2","SLC8A1","GPR18","F2RL2","CCR5","CCL1","PTPRC","FPR2","ACKR4","TGFB1","CCL19","CCR6","PDGFRA","LPAR1","CCL3","CX3CL1","PLCB1","CLIC2","SMAD3"]} {"pathway":"GO_DEFENSE_RESPONSE_TO_GRAM_POSITIVE_BACTERIUM","pval":0.42515,"padj":0.89739,"ES":0.7184,"NES":1.04376,"nMoreExtreme":28599,"size":37,"leadingEdge":["P2RX7","HLA-E","RIPK2","GSDMD","IL12A","LTA","TNFRSF14","MYD88","IL6","TNF"]} {"pathway":"GO_REGENERATION","pval":0.38363,"padj":0.89036,"ES":0.61226,"NES":1.04374,"nMoreExtreme":32056,"size":148,"leadingEdge":["HGF","KREMEN1","JAK2","KLF4","SCARF1","IGF2R","DYSF","NR4A3","PTPRU","ANXA3","FGF10","DUSP10","CXCL12","TGFB1","CDKN1A","UCP2","RGMA","GAS6","CFLAR","BAK1","MYOZ1"]} {"pathway":"GO_NON_CANONICAL_WNT_SIGNALING_PATHWAY","pval":0.38769,"padj":0.89277,"ES":0.61662,"NES":1.04371,"nMoreExtreme":31950,"size":135,"leadingEdge":["PSME2","PSMB9","PSME1","PSMB10","PSMB8","PSMA4","PSMA2","MOV10","PSMA5","PLCB1"]} {"pathway":"GO_GLIAL_CELL_PROLIFERATION","pval":0.42202,"padj":0.89612,"ES":0.71218,"NES":1.0437,"nMoreExtreme":28664,"size":39,"leadingEdge":["ASCL2","LYN","CSF1","LTA","IL6","TNF","CX3CL1","IL33","PTN"]} {"pathway":"GO_RESPONSE_TO_OXYGEN_RADICAL","pval":0.46214,"padj":0.90517,"ES":0.76941,"NES":1.04351,"nMoreExtreme":29267,"size":24,"leadingEdge":["GCH1","SOD2","TNF","UCP2","PRDX1","NFE2L2"]} {"pathway":"GO_ACTIVATION_OF_NF_KAPPAB_INDUCING_KINASE_ACTIVITY","pval":0.52186,"padj":0.9256,"ES":0.80684,"NES":1.04342,"nMoreExtreme":31535,"size":17,"leadingEdge":["TLR3","CHI3L1","TRAF4"]} {"pathway":"GO_PERIPHERAL_NERVOUS_SYSTEM_DEVELOPMENT","pval":0.40888,"padj":0.89503,"ES":0.67169,"NES":1.04296,"nMoreExtreme":29535,"size":59,"leadingEdge":["EGR2","ONECUT2","EGR3","SOX8","RUNX1","ISL2","ADGRB1","NGF"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MACROPHAGE_ACTIVATION","pval":0.46296,"padj":0.90517,"ES":0.76897,"NES":1.04292,"nMoreExtreme":29319,"size":24,"leadingEdge":["LRRK2","STAP1","CCL3","IL33","TLR4"]} {"pathway":"GO_PYRIDINE_CONTAINING_COMPOUND_METABOLIC_PROCESS","pval":0.43247,"padj":0.90066,"ES":0.73084,"NES":1.04276,"nMoreExtreme":28587,"size":33,"leadingEdge":["CD38","KMO","NADK","MDH1"]} {"pathway":"GO_COBALAMIN_TRANSPORT","pval":0.64981,"padj":0.94878,"ES":0.79706,"NES":1.04262,"nMoreExtreme":35320,"size":7,"leadingEdge":["TCN2","AMN","ABCC1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY","pval":0.46999,"padj":0.9079,"ES":0.77356,"NES":1.04244,"nMoreExtreme":29570,"size":23,"leadingEdge":["LAG3","HLA-F","HLA-E","SLAMF6","HLA-G","IL12A","CD226","RASGRP1","MICB","IL18RAP"]} {"pathway":"GO_RESPONSE_TO_PEPTIDOGLYCAN","pval":0.61271,"padj":0.94703,"ES":0.8231,"NES":1.0423,"nMoreExtreme":34985,"size":11,"leadingEdge":["NOD2","RIPK2","IL6","IRF5"]} {"pathway":"GO_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS","pval":0.4386,"padj":0.90126,"ES":0.7382,"NES":1.04205,"nMoreExtreme":28712,"size":31,"leadingEdge":["IDO1","CD274","PDCD1","JAK3","GIMAP8","CCL5","PRELID1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ISOTYPE_SWITCHING_TO_IGA_ISOTYPES","pval":0.60819,"padj":0.94703,"ES":0.75749,"NES":1.04199,"nMoreExtreme":32181,"size":5,"leadingEdge":["TGFB1","MLH1"]} {"pathway":"GO_LEUKOCYTE_CHEMOTAXIS","pval":0.38532,"padj":0.89163,"ES":0.60314,"NES":1.04194,"nMoreExtreme":33062,"size":178,"leadingEdge":["CD74","CXCL11","PDE4B","CXCL10","CCL13","CXCL9","PADI2","CCL7","HSD3B7","CCL15","CCL8","STAP1","EDN1","VEGFC","IL1RN","DYSF","SLAMF8","CCL18","CCL5","LYN","IL12A","CSF1","CXCL16","IL6","FLT1","CH25H","GPR18","CAMK1D","CCR5","CCL1","CXCL12","CCL4","FPR2","CCL2","CCL19","CCR6","CXCL8","RIPOR2","GAS6","CCL3","CX3CL1","DAPK2","PDGFB","SLIT2","FCER1G"]} {"pathway":"GO_CD8_POSITIVE_ALPHA_BETA_T_CELL_DIFFERENTIATION","pval":0.61294,"padj":0.94703,"ES":0.82271,"NES":1.04181,"nMoreExtreme":34998,"size":11,"leadingEdge":["IRF1","SOCS1","GPR18","RUNX1"]} {"pathway":"GO_CRANIOFACIAL_SUTURE_MORPHOGENESIS","pval":0.55102,"padj":0.93224,"ES":0.81539,"NES":1.04177,"nMoreExtreme":32742,"size":15,"leadingEdge":["TIFAB","TGFB1","INSIG2","NEUROG1"]} {"pathway":"GO_TYPE_B_PANCREATIC_CELL_PROLIFERATION","pval":0.55142,"padj":0.93271,"ES":0.81506,"NES":1.04135,"nMoreExtreme":32766,"size":15,"leadingEdge":["SIDT2","NR4A3","BAD"]} {"pathway":"GO_CD40_SIGNALING_PATHWAY","pval":0.64707,"padj":0.94878,"ES":0.80673,"NES":1.04125,"nMoreExtreme":35653,"size":8,"leadingEdge":["SLAMF1","TNFAIP3","RNF31"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ATPASE_ACTIVITY","pval":0.41604,"padj":0.89503,"ES":0.68896,"NES":1.04105,"nMoreExtreme":29128,"size":48,"leadingEdge":["ATP1B2","PLSCR1","FGF10","NAPA"]} {"pathway":"GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE","pval":0.41119,"padj":0.89503,"ES":0.66755,"NES":1.04103,"nMoreExtreme":29883,"size":61,"leadingEdge":["SUCNR1","AGT","EDN1","SOD2","CTSZ","GAS6","CES1","PDGFB","KLK1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS","pval":0.33258,"padj":0.87414,"ES":0.56975,"NES":1.04096,"nMoreExtreme":32986,"size":860,"leadingEdge":["IL31RA","CD40","CD74","P2RX7","SOCS1","LRRK2","IL15","NOD2","CCL13","PLEK","HGF","BANK1","JAK2","AGT","RIPK2","CCL7","FAS","ACSL1","ICAM1","CCL15","FLT3LG","TNFSF18","CD80","FAM20A","CCL8","C3","SCIMP","ZC3H12A","RAPGEF2","STAP1","ENPP2","RALB","EDN1","VEGFC","SLAMF1","NCF1","NRK","IL1RN","GADD45B","STAP2","GLIPR2","CCL18","CCL5","LYN","IL12A","PARP14","CSF1","TNFRSF14","PARP9","GAREM1","IL6","TLR3","FGF10","TXN","GADD45G","SEMA7A","NOTCH2","TNF","FLT1","RASGRP1","CCL1","FGD2","LCP2","PTPRC","CHI3L1","CCL4","FPR2","SOCS3","CCL2","STAT3","NBN","P2RY12","PAK1","SRC","TGFB1","ROBO1","CCL19","CDKN1A","PDGFRA","DUSP5","PTPN1","SH3RF1","LPAR1","PTGS2","GAS6","CCL3","CX3CL1","CFLAR","TCIM","BIRC7","NKX3-1","SRCIN1","PPARGC1B","SEMA4D","PLCB1","PDGFB","SMAD3"]} {"pathway":"GO_GLIAL_CELL_DEVELOPMENT","pval":0.39848,"padj":0.89503,"ES":0.63882,"NES":1.04085,"nMoreExtreme":30757,"size":90,"leadingEdge":["KCNJ10","LYN","B4GALT5","IL6","TNF","ASCL1","FPR2","TGFB1","LPAR1","TLR4","ADORA2A"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS","pval":0.36393,"padj":0.89036,"ES":0.57543,"NES":1.04064,"nMoreExtreme":34987,"size":470,"leadingEdge":["GBP1","P2RX7","SOCS1","LRRK2","CEACAM1","HGF","ATF3","LMTK2","KLF4","ZC3H12A","CYLD","STAP1","BTN2A2","MIR503","MVP","GADD45B","PPM1E","LYN","DTNBP1","PARP14","TNFAIP3","TNF","DUSP10","PTPRC","RHOH","SOCS3","PTPN2","TGFB1","CDKN1A","ADAR","DUSP5","CDKN1C","PTPN1","ELFN1","SRCIN1","MIR212","SEMA4D","SPINK1","SLIT2","BAK1","PRR5L","MYOZ1","C9orf72","PPP1R16B","HEG1","TLR4"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_IONIZING_RADIATION","pval":0.40799,"padj":0.89503,"ES":0.6576,"NES":1.04054,"nMoreExtreme":30197,"size":69,"leadingEdge":["TMEM109","TANK","TGFB1","CDKN1A","NAMPT","LIG4","GATA3","KDM1A"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS","pval":0.32494,"padj":0.87041,"ES":0.56863,"NES":1.0402,"nMoreExtreme":32332,"size":985,"leadingEdge":["IL31RA","CD40","CD74","P2RX7","SOCS1","LRRK2","IL15","NOD2","CCL13","HGF","BANK1","NMI","JAK2","AGT","RIPK2","CCL7","FAS","ACSL1","ICAM1","MUC1","CCL15","FLT3LG","TNFSF18","CD80","FAM20A","CCL8","C3","SCIMP","ZC3H12A","RAPGEF2","STAP1","ENPP2","RALB","EDN1","VEGFC","SLAMF1","NCF1","NRK","FAM107A","IL1RN","GADD45B","STAP2","GLIPR2","BCL6","CCL18","CCL5","LYN","IL12A","TRABD2A","PARP14","CSF1","TNFRSF14","TANK","PARP9","AMER1","GAREM1","BIRC3","IL6","TLR3","FGF10","TXN","GADD45G","SEMA7A","NOTCH2","TNF","FLT1","RASGRP1","CCL1","FGD2","LCP2","PTPRC","CHI3L1","CCL4","AUTS2","FPR2","SOCS3","CCL2","STAT3","NBN","PAK1","SRC","TGFB1","ROBO1","CCL19","CDKN1A","PDGFRA","DUSP5","PTPN1","SH3RF1","LPAR1","PTGS2","GAS6","CCL3","CX3CL1","CFLAR","TCIM","GATA3","BIRC7","NKX3-1","SRCIN1","SEMA4D"]} {"pathway":"GO_REGULATION_OF_PHOSPHATIDYLINOSITOL_DEPHOSPHORYLATION","pval":0.60872,"padj":0.94703,"ES":0.75614,"NES":1.04013,"nMoreExtreme":32209,"size":5,"leadingEdge":["MTMR1","MTMR2","MTMR3","MTMR9","MTMR4"]} {"pathway":"GO_REGULATION_OF_TRANSPOSITION","pval":0.53914,"padj":0.92855,"ES":0.80952,"NES":1.03996,"nMoreExtreme":32295,"size":16,"leadingEdge":["APOBEC3D","APOBEC3A","APOBEC3G","PIWIL4","TDRD9","APOBEC3F","MOV10"]} {"pathway":"GO_NITRIC_OXIDE_BIOSYNTHETIC_PROCESS","pval":0.41341,"padj":0.89503,"ES":0.66678,"NES":1.03983,"nMoreExtreme":30044,"size":61,"leadingEdge":["GCH1","JAK2","AGT","ICAM1","KLF4","ZC3H12A","P2RX4","EDN1","TNF","CD47","SLC7A2","PTGS2","MIR212","SMAD3","TLR4","ASS1"]} {"pathway":"GO_REGULATION_OF_HORMONE_METABOLIC_PROCESS","pval":0.44234,"padj":0.90221,"ES":0.7363,"NES":1.03936,"nMoreExtreme":28957,"size":31,"leadingEdge":["TNF","HPN","CYP27B1","GATA3","DKK3"]} {"pathway":"GO_G1_TO_G0_TRANSITION","pval":0.64788,"padj":0.94878,"ES":0.80521,"NES":1.0393,"nMoreExtreme":35698,"size":8,"leadingEdge":["SMPD3","CYP27B1","RAB11FIP4","CAPN3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS","pval":0.39528,"padj":0.89503,"ES":0.61235,"NES":1.03927,"nMoreExtreme":32756,"size":140,"leadingEdge":["BANK1","XRN1","SAMD4A","ZC3H12A","MIR503","MOV10","STAT3","TRIM71","LIN28A","MIR212","ZFP36","HAP1","PLEKHN1","BTG2"]} {"pathway":"GO_ALPHA_LINOLENIC_ACID_METABOLIC_PROCESS","pval":0.59917,"padj":0.94564,"ES":0.82049,"NES":1.039,"nMoreExtreme":34561,"size":12,"leadingEdge":["ACSL1","ELOVL5"]} {"pathway":"GO_REGULATION_OF_CATION_CHANNEL_ACTIVITY","pval":0.39962,"padj":0.89503,"ES":0.61858,"NES":1.03874,"nMoreExtreme":32458,"size":123,"leadingEdge":["PDE4B","CAMK2D","SRI","RASGRF1","CTSS","ANK2","DYSF","KCNE5","ANXA3","RNF207","STAC3","JPH4","GEM","KCNE1","ACTN2","RGS9","MIR212","CLIC2","KCNE1B","STOM","SHISA7","S100A1","ARC","MAPK8IP2","GPR35","HAP1"]} {"pathway":"GO_HISTONE_H4_ACETYLATION","pval":0.41434,"padj":0.89503,"ES":0.66357,"NES":1.03862,"nMoreExtreme":30262,"size":63,"leadingEdge":["MUC1","JADE2","IRF4","NCOA1","AUTS2","MSL3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MYOTUBE_DIFFERENTIATION","pval":0.47487,"padj":0.91067,"ES":0.77071,"NES":1.0386,"nMoreExtreme":29877,"size":23,"leadingEdge":["CXCL9","FLT3LG","ADGRB1","RIPOR2","CD53","FLOT1","TBX1","EHD1","CYP26B1"]} {"pathway":"GO_REGULATION_OF_COAGULATION","pval":0.41798,"padj":0.89503,"ES":0.67368,"NES":1.03859,"nMoreExtreme":29902,"size":56,"leadingEdge":["SERPING1","CEACAM1","PLEK","ENPP4","EDN1","LYN","PROCR","F3","GP1BA","PDGFRA","NFE2L2","PDGFB","FCER1G","TLR4"]} {"pathway":"GO_RECEPTOR_METABOLIC_PROCESS","pval":0.39473,"padj":0.89503,"ES":0.60656,"NES":1.03844,"nMoreExtreme":33275,"size":156,"leadingEdge":["CEACAM1","LMTK2","OPTN","EDN1","DTX3L","TNF","NR1H3","LILRB1","TGFB1","CXCL8","UVRAG","PTPN1","AP1AR","ANKRD13A","FCER1G","FLOT1","ARC"]} {"pathway":"GO_REGULATION_OF_CELL_POPULATION_PROLIFERATION","pval":0.31293,"padj":0.86489,"ES":0.56696,"NES":1.03839,"nMoreExtreme":31249,"size":1262,"leadingEdge":["IRF1","HLA-DPA1","PLAAT4","IL31RA","IDO1","HLA-DMB","ASCL2","CD40","CD74","CD274","LRRK2","IL12RB1","CXCL11","CD38","PDCD1LG2","IL15","HLA-DPB1","CXCL10","NOD2","CEACAM1","HLA-E","CXCL9","CHRD","ATF3","SSTR2","STAT1","CTLA4","JAK2","AGT","PIM1","RIPK2","OVOL1","TNFSF13B","IL27","VCAM1","KLF4","TGM2","IFITM1","FLT3LG","TNFSF18","CD80","TSPAN32","PML","CCL8","S100A13","IFIT3","PARP10","JAK3","RAPGEF2","SCIN","ATF5","NPR1","IL12RB2","BTN2A2","EDN1","VEGFC","SLAMF1","NRK","MIR503","SAT1","COMP","DYSF","HLA-G","BCL6","CCL5","LYN","IL12A","GLUL","CSF1","LTA","NR4A3","TNFRSF14","IL7","SOD2","PTPRU","GAREM1","TNFAIP3","CTSZ","IL6","FGF10","EGR3","TBX19","CHST11","TNF","SOX8","PTGER2","STAT5A","EBI3","FLT1","HPN","CUL1","DUSP10","CD86","PLA2G4A","CD47","SMPD3","UBE2A","ASCL1","NTN1","CXCL12","CYP27B1","PTPRC","PTAFR","LILRB1","F3","CCL2","STAT3","PTPN2","PAK1","TRIM71","MNDA","TGFB1","OCSTAMP","CCDC88B","ROBO1","IL2RA","CCL19","CXCL8","CDKN1A","AKIRIN2","TXNIP","PDGFRA","NAMPT","CDKN1C","NFKBIA","EGR4","ADGRB1","LIG4","PKHD1","SH3RF1","PTGS2","HAS2","PLPP1","RARRES1","GAS6","CX3CL1","TNS3","CFLAR","ESM1","LIFR","GATA3","BIRC7","NKX3-1","LIN28A","ADAMTS8","CCNA1"]} {"pathway":"GO_REGULATION_OF_PROGRAMMED_NECROTIC_CELL_DEATH","pval":0.51599,"padj":0.92482,"ES":0.79711,"NES":1.03812,"nMoreExtreme":31393,"size":18,"leadingEdge":["CYLD","BIRC3","RBCK1","CFLAR","YBX3"]} {"pathway":"GO_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY","pval":0.41358,"padj":0.89503,"ES":0.65785,"NES":1.03777,"nMoreExtreme":30505,"size":67,"leadingEdge":["PDE4B","CAMK2D","SRI","ANK2","DYSF","STAC3","JPH4","GEM","CLIC2","S100A1","GPR35","HAP1"]} {"pathway":"GO_IMMUNOGLOBULIN_PRODUCTION_INVOLVED_IN_IMMUNOGLOBULIN_MEDIATED_IMMUNE_RESPONSE","pval":0.42044,"padj":0.89612,"ES":0.68312,"NES":1.03776,"nMoreExtreme":29573,"size":50,"leadingEdge":["CD40","TBX21","HLA-DQB1","GCNT3","BCL6","PARP3","PTPRC","NBN","TGFB1","CCR6","LIG4"]} {"pathway":"GO_RESPONSE_TO_INSECTICIDE","pval":0.63168,"padj":0.94878,"ES":0.81725,"NES":1.03753,"nMoreExtreme":35655,"size":10,"leadingEdge":["CYP1A1","ZC3H12A","KIF1B"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS","pval":0.50656,"padj":0.92092,"ES":0.79123,"NES":1.03753,"nMoreExtreme":31111,"size":19,"leadingEdge":["IDO1","JAK3","CCL5","PRKCQ"]} {"pathway":"GO_SODIUM_ION_TRANSPORT","pval":0.39963,"padj":0.89503,"ES":0.61116,"NES":1.03725,"nMoreExtreme":33117,"size":140,"leadingEdge":["ATP1B2","P2RX7","SLC12A3","CAMK2D","SPTBN4","P2RX4","SLC8A1","SCN9A","SLC4A10","TGFB1","SLC8A2","GLRX","STOM","SIK1"]} {"pathway":"GO_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME","pval":0.41017,"padj":0.89503,"ES":0.63985,"NES":1.03666,"nMoreExtreme":31406,"size":85,"leadingEdge":["RBM11","RBM5"]} {"pathway":"GO_REGULATION_OF_BRANCHING_INVOLVED_IN_LUNG_MORPHOGENESIS","pval":0.639,"padj":0.94878,"ES":0.77511,"NES":1.03646,"nMoreExtreme":34294,"size":6,"leadingEdge":["TNF","WNT2"]} {"pathway":"GO_ADENYLATE_CYCLASE_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY","pval":0.41488,"padj":0.89503,"ES":0.64738,"NES":1.03634,"nMoreExtreme":31213,"size":76,"leadingEdge":["CXCL11","CXCL10","ADGRE5","RXFP1","CXCL9","RAPGEF2","ADGRG5","PTGER4","PTGER2","ADM2","ADGRB1"]} {"pathway":"GO_INTERLEUKIN_4_PRODUCTION","pval":0.45723,"padj":0.90517,"ES":0.74529,"NES":1.03572,"nMoreExtreme":29535,"size":28,"leadingEdge":["ITK","HLA-E","CD83","IRF4","CD86","GATA3","IL33","FCER1G"]} {"pathway":"GO_POSITIVE_REGULATION_OF_FIBROBLAST_MIGRATION","pval":0.61809,"padj":0.94878,"ES":0.81782,"NES":1.03562,"nMoreExtreme":35292,"size":11,"leadingEdge":["SLC8A1","PAK1","TGFB1","PAK3"]} {"pathway":"GO_REGULATION_OF_VASCULAR_SMOOTH_MUSCLE_CELL_DIFFERENTIATION","pval":0.58631,"padj":0.94167,"ES":0.81718,"NES":1.03551,"nMoreExtreme":34146,"size":13,"leadingEdge":["SOD2","PDGFB","NFATC1","NFATC3"]} {"pathway":"GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_OXIDATIVE_STRESS","pval":0.43636,"padj":0.90126,"ES":0.70966,"NES":1.03543,"nMoreExtreme":29505,"size":38,"leadingEdge":["JAK2","PML","SOD2","MCL1","NFE2L2"]} {"pathway":"GO_PHAGOLYSOSOME_ASSEMBLY","pval":0.58687,"padj":0.94167,"ES":0.81676,"NES":1.03498,"nMoreExtreme":34179,"size":13,"leadingEdge":["P2RX7","RAB20","RAB39A"]} {"pathway":"GO_TOOTH_ERUPTION","pval":0.60973,"padj":0.94703,"ES":0.75233,"NES":1.03488,"nMoreExtreme":32262,"size":5,"leadingEdge":["SNX10","FAM20A","COL1A1"]} {"pathway":"GO_REGULATION_OF_EPIDERMIS_DEVELOPMENT","pval":0.42444,"padj":0.89678,"ES":0.67126,"NES":1.03484,"nMoreExtreme":30364,"size":56,"leadingEdge":["MAFF","CTSL","TNF","FST","CYP27B1","RUNX1","FOXC1","ZFP36","MYCL"]} {"pathway":"GO_MITOCHONDRION_ORGANIZATION","pval":0.38155,"padj":0.89036,"ES":0.57187,"NES":1.0348,"nMoreExtreme":36744,"size":484,"leadingEdge":["P2RX7","LRRK2","HGF","TNFSF10","ATP13A2","OPTN","STAT2","TYMP","BCL2L11","AIFM2","IFIT2","ALAS1","PMAIP1","SCO2","SOD2","MX1","ATG3","STAT3","GCLC","IFI6","PARL","PRELID1","BBC3","RAB38","BAK1","DDHD1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MICROGLIAL_CELL_ACTIVATION","pval":0.61877,"padj":0.94878,"ES":0.81705,"NES":1.03465,"nMoreExtreme":35331,"size":11,"leadingEdge":["LRRK2","STAP1","CCL3"]} {"pathway":"GO_URETER_MORPHOGENESIS","pval":0.65314,"padj":0.94878,"ES":0.79091,"NES":1.03458,"nMoreExtreme":35501,"size":7,"leadingEdge":["SOX8","GATA3","LZTS2"]} {"pathway":"GO_ATRIAL_SEPTUM_MORPHOGENESIS","pval":0.60297,"padj":0.94684,"ES":0.81671,"NES":1.03422,"nMoreExtreme":34780,"size":12,"leadingEdge":["NOTCH2","TGFB2"]} {"pathway":"GO_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY_INVOLVED_IN_CELL_CELL_SIGNALING","pval":0.38228,"padj":0.89036,"ES":0.5708,"NES":1.03415,"nMoreExtreme":36957,"size":510,"leadingEdge":["PSME2","P2RX7","LRRK2","PSMB9","KREMEN1","PSME1","DKK2","PSMB10","PSMB8","KLF4","C3","CMAHP","CYLD","P2RX4","TRABD2A","PTPRU","AMER1","TNFAIP3","FGF10","PSMA4","PSMA2","CUL1","MOV10","TCF7L1","NR4A2","RUNX1","SRC","VAX2","PSMA5"]} {"pathway":"GO_REGULATION_OF_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_ALPHA_SIGNALING_PATHWAY","pval":0.55885,"padj":0.93517,"ES":0.72599,"NES":1.03383,"nMoreExtreme":29085,"size":4,"leadingEdge":["PHF14","IFT20","CBL","CBLB"]} {"pathway":"GO_REGULATION_OF_REGULATED_SECRETORY_PATHWAY","pval":0.40952,"padj":0.89503,"ES":0.61337,"NES":1.03353,"nMoreExtreme":33469,"size":128,"leadingEdge":["LRRK2","HLA-F","CEACAM1","GRIN3A","LYN","DTNBP1","PTAFR","CACNA1I","TRIM9","SYT5","NAPA","SYT17","FCER1G"]} {"pathway":"GO_GLYCOSYLATION","pval":0.4016,"padj":0.89503,"ES":0.58991,"NES":1.03346,"nMoreExtreme":35543,"size":222,"leadingEdge":["IL15","MUC1","TMTC1","GCNT3","B4GALT5","ST3GAL5","TMTC2","GALNT12","ST6GALNAC2","FUT4","LMF1","SLC35C2","NPC1","GALNT3","FUT1","GCNT1","B3GALT5"]} {"pathway":"GO_REGULATION_OF_MESONEPHROS_DEVELOPMENT","pval":0.48787,"padj":0.91689,"ES":0.77177,"NES":1.03326,"nMoreExtreme":30526,"size":22,"leadingEdge":["AGT","SOX8","TGFB1","GATA3","HNF1B","SIX1"]} {"pathway":"GO_ASPARTATE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS","pval":0.51161,"padj":0.92419,"ES":0.78788,"NES":1.03313,"nMoreExtreme":31421,"size":19,"leadingEdge":["SDSL","SDS","AASS"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MULTI_ORGANISM_PROCESS","pval":0.40705,"padj":0.89503,"ES":0.60277,"NES":1.03291,"nMoreExtreme":34378,"size":158,"leadingEdge":["CD74","ACOD1","OPTN","RIPK2","BCL2L11","DDX60","CHMP4C","CCL5","HPN","PTAFR","DHX58","TRIM21","ADAR","PLCB1","STOM","GTF2B"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION","pval":0.42642,"padj":0.89849,"ES":0.66637,"NES":1.03269,"nMoreExtreme":30711,"size":58,"leadingEdge":["JAK2","RASGRF1","LYN","CSF1","FGF10","NOTCH2","GPR18","RASGRP1","F2RL2","AUTS2","SRC","ROBO1","LPAR1","NGF","GPR35"]} {"pathway":"GO_GRANULOCYTE_MACROPHAGE_COLONY_STIMULATING_FACTOR_PRODUCTION","pval":0.62037,"padj":0.94878,"ES":0.81528,"NES":1.0324,"nMoreExtreme":35422,"size":11,"leadingEdge":["CD80","LILRA2","RASGRP1","DDX58","CD84"]} {"pathway":"GO_MYELOID_CELL_HOMEOSTASIS","pval":0.41144,"padj":0.89503,"ES":0.61337,"NES":1.03239,"nMoreExtreme":33562,"size":126,"leadingEdge":["PDE4B","STAT1","HCAR2","JAK2","BCL2L11","B2M","JAK3","BCL6","LYN","IL6","STAT3","PTPN2","PRDX1","ISG15","GATA3","ZFP36","BAK1","FCER1G"]} {"pathway":"GO_VESICLE_MEDIATED_TRANSPORT_IN_SYNAPSE","pval":0.40773,"padj":0.89503,"ES":0.59932,"NES":1.03226,"nMoreExtreme":34783,"size":170,"leadingEdge":["P2RX7","LRRK2","STX11","GRIN3A","ERC2","PRRT2","DTNBP1","CADPS2","TRIM9","SYT5","MAP2","NAPA","STX3","SYT17","TRIM46","ARC","CADPS","ADORA2A"]} {"pathway":"GO_POSITIVE_REGULATION_OF_AMINE_TRANSPORT","pval":0.50425,"padj":0.91988,"ES":0.78166,"NES":1.03195,"nMoreExtreme":31169,"size":20,"leadingEdge":["P2RX7","AGT","CXCL12","KMO","ADORA2A"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS","pval":0.43542,"padj":0.90091,"ES":0.69145,"NES":1.03164,"nMoreExtreme":30125,"size":44,"leadingEdge":["PML","WNT1","PANO1"]} {"pathway":"GO_REGULATION_OF_MAP_KINASE_ACTIVITY","pval":0.4017,"padj":0.89503,"ES":0.58044,"NES":1.03161,"nMoreExtreme":36852,"size":294,"leadingEdge":["CD40","CD74","P2RX7","LRRK2","NOD2","HGF","JAK2","RIPK2","EDN1","NRK","GADD45B","LYN","DTNBP1","FGF10","GADD45G","TNF","FLT1","DUSP10","RASGRP1","FGD2","PTPRC","PAK1","SRC","TGFB1","ROBO1","CCL19","DUSP5","PTPN1","LPAR1"]} {"pathway":"GO_MYOBLAST_PROLIFERATION","pval":0.62103,"padj":0.94878,"ES":0.81457,"NES":1.0315,"nMoreExtreme":35460,"size":11,"leadingEdge":["HGF","IGF1"]} {"pathway":"GO_DNA_CATABOLIC_PROCESS","pval":0.45197,"padj":0.90517,"ES":0.72657,"NES":1.03118,"nMoreExtreme":29722,"size":32,"leadingEdge":["ISG20","ERI1","CECR2","DNASE1L1"]} {"pathway":"GO_REGULATION_OF_KERATINOCYTE_PROLIFERATION","pval":0.49047,"padj":0.91801,"ES":0.77014,"NES":1.03107,"nMoreExtreme":30689,"size":22,"leadingEdge":["FGF10","HAS2","ZFP36","SNAI2"]} {"pathway":"GO_MAMMARY_GLAND_DUCT_MORPHOGENESIS","pval":0.46057,"padj":0.90517,"ES":0.73801,"NES":1.03107,"nMoreExtreme":29887,"size":29,"leadingEdge":["PML","CSF1","FGF10","NTN1","SRC","TGFB1"]} {"pathway":"GO_TIGHT_JUNCTION_ORGANIZATION","pval":0.43425,"padj":0.90066,"ES":0.68412,"NES":1.03079,"nMoreExtreme":30308,"size":47,"leadingEdge":["MARVELD2","TNF","RUNX1","LSR"]} {"pathway":"GO_MODULATION_BY_HOST_OF_VIRAL_PROCESS","pval":0.4849,"padj":0.91689,"ES":0.76489,"NES":1.03076,"nMoreExtreme":30508,"size":23,"leadingEdge":["IFI27","CCL8","ZC3H12A","STOM"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY","pval":0.57649,"padj":0.94161,"ES":0.80979,"NES":1.03054,"nMoreExtreme":33932,"size":14,"leadingEdge":["CARD16","PTPN2","GAS6","GSTP1"]} {"pathway":"GO_B_CELL_DIFFERENTIATION","pval":0.41877,"padj":0.89569,"ES":0.62926,"NES":1.03029,"nMoreExtreme":32592,"size":94,"leadingEdge":["VCAM1","JAK3","CYLD","SLAMF8","BCL6","NOTCH2","PTPRC","TPD52","KLF6","PTPN2","BAK1","NFAM1","BLNK"]} {"pathway":"GO_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS","pval":0.41541,"padj":0.89503,"ES":0.60894,"NES":1.03016,"nMoreExtreme":34187,"size":134,"leadingEdge":["P2RX7","LRRK2","GCH1","ACOD1","AGT","ZC3H12A","EDN1","NCF1","PMAIP1","NCF1B","NCF1C","SOD2","TNF","FPR2","TGFB1","CDKN1A","PRDX1","IFI6","NCF2","PARL","NFE2L2","PDGFB","RFK"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_BINDING","pval":0.41512,"padj":0.89503,"ES":0.60511,"NES":1.02981,"nMoreExtreme":34564,"size":145,"leadingEdge":["LRRK2","JAK2","SRI","B2M","IFIT2","CARD16","XIRP1","RALB","DTNBP1","CTSZ","TEX14","NFKBIA","MAP2","RIPOR2","MITD1","NKX3-1","PDGFB","C9orf72"]} {"pathway":"GO_WALKING_BEHAVIOR","pval":0.49904,"padj":0.91909,"ES":0.77451,"NES":1.02962,"nMoreExtreme":31058,"size":21,"leadingEdge":["KCNJ10","SPTBN4","CTNS","NPC1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY","pval":0.40848,"padj":0.89503,"ES":0.57935,"NES":1.02927,"nMoreExtreme":37433,"size":292,"leadingEdge":["CD40","CD74","P2RX7","LRRK2","NOD2","HGF","JAK2","RIPK2","ACSL1","FAM20A","RAPGEF2","RALB","EDN1","NRK","GADD45B","FGF10","GADD45G","TNF","FLT1","RASGRP1","FGD2","PTPRC","PAK1","SRC","TGFB1","ROBO1","CCL19","DUSP5","PTPN1","LPAR1","TCIM","BIRC7"]} {"pathway":"GO_REGULATION_OF_SYNAPTIC_PLASTICITY","pval":0.41664,"padj":0.89503,"ES":0.60433,"NES":1.02915,"nMoreExtreme":34747,"size":146,"leadingEdge":["CD38","EGR2","KCNJ10","AGT","PRRT2","RASGRF1","RAPGEF2","FAM107A","JPH4","ADGRB1","PTGS2","CX3CL1","SLC8A2","STX3","SHISA7","ARC","ADORA2A","PTN","LZTS1"]} {"pathway":"GO_CALCIUM_MEDIATED_SIGNALING","pval":0.41531,"padj":0.89503,"ES":0.59768,"NES":1.02893,"nMoreExtreme":35411,"size":169,"leadingEdge":["GBP1","P2RX7","LRRK2","PLEK","CAMK2D","VCAM1","SRI","CCRL2","P2RX4","MCTP2","EDN1","ANK2","JPH4","TNF","SLC8A1","CCR5","PTPRC","CCL4","FPR2","ACKR4","P2RY12","CCR6","CXCL8"]} {"pathway":"GO_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA","pval":0.43416,"padj":0.90066,"ES":0.6718,"NES":1.0288,"nMoreExtreme":30827,"size":53,"leadingEdge":["HGF","TNFSF10","BCL2L11","PMAIP1","SOD2","IFI6","PRELID1","BBC3","BAK1"]} {"pathway":"GO_ACTIVATION_OF_PROTEIN_KINASE_ACTIVITY","pval":0.41078,"padj":0.89503,"ES":0.57938,"NES":1.02845,"nMoreExtreme":37555,"size":286,"leadingEdge":["CD74","P2RX7","SOCS1","LRRK2","NOD2","HGF","JAK2","AGT","RIPK2","NRK","GADD45B","CCL5","TLR3","FGF10","TXN","GADD45G","TNF","PTPRC","CHI3L1","PAK1","SRC","CCL19","DUSP5","PTPN1","LPAR1","GAS6","BIRC7","PDGFB","MAP3K8","NGF"]} {"pathway":"GO_AMINOGLYCAN_METABOLIC_PROCESS","pval":0.4227,"padj":0.89612,"ES":0.61829,"NES":1.0282,"nMoreExtreme":33760,"size":110,"leadingEdge":["IL15","HGF","PIM1","SDC3","DSE","B4GALT5","CHST11","HS3ST3B1","SMPD3","TGFB1","CHST2","HAS2","FOXC1","HS3ST3A1","PDGFB"]} {"pathway":"GO_REGULATION_OF_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES","pval":0.45824,"padj":0.90517,"ES":0.72834,"NES":1.02813,"nMoreExtreme":29998,"size":31,"leadingEdge":["LRRK2","GCH1","HGF","NR4A3","TXN","TNF","NFE2L2"]} {"pathway":"GO_PROTEIN_OXIDATION","pval":0.57914,"padj":0.94163,"ES":0.8076,"NES":1.02775,"nMoreExtreme":34088,"size":14,"leadingEdge":["TRABD2A","LOX"]} {"pathway":"GO_REGULATION_OF_B_CELL_APOPTOTIC_PROCESS","pval":0.53922,"padj":0.92855,"ES":0.79458,"NES":1.02757,"nMoreExtreme":32584,"size":17,"leadingEdge":["CD74","BCL6","LYN","BTK"]} {"pathway":"GO_REGULATION_OF_MUSCLE_HYPERTROPHY","pval":0.43799,"padj":0.90126,"ES":0.67638,"NES":1.02752,"nMoreExtreme":30807,"size":50,"leadingEdge":["AGT","CAMK2D","P2RX4","EDN1","NR4A3","PAK1","SMAD3"]} {"pathway":"GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_VACUOLE","pval":0.44627,"padj":0.90517,"ES":0.70113,"NES":1.02751,"nMoreExtreme":30311,"size":39,"leadingEdge":["TNFAIP3","SNX16","NCOA4","GCC2","M6PR"]} {"pathway":"GO_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS","pval":0.4375,"padj":0.90126,"ES":0.66462,"NES":1.02723,"nMoreExtreme":31388,"size":57,"leadingEdge":["ACSL1","CYP1A1","ACOT4","SLC27A3","PLA2G4C","CBR1","PLA2G4A","ACSL5","PTGS2","CPT1A"]} {"pathway":"GO_PROSTATIC_BUD_FORMATION","pval":0.65603,"padj":0.94878,"ES":0.78475,"NES":1.02652,"nMoreExtreme":35658,"size":7,"leadingEdge":["FGF10","GLI2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CATALYTIC_ACTIVITY","pval":0.37464,"padj":0.89036,"ES":0.5605,"NES":1.02639,"nMoreExtreme":37395,"size":1213,"leadingEdge":["ATP1B2","PSME2","AIM2","CD40","CD74","P2RX7","SOCS1","LRRK2","GCH1","ITK","NOD2","CCL13","PLEK","HGF","TNFSF10","PSME1","TAGAP","JAK2","AGT","RIPK2","CCL7","FAS","ACSL1","ICAM1","KLF4","BCL2L11","ARAP2","CCL15","VPS9D1","RSU1","PML","FAM20A","CCL8","MEFV","RASGRF1","RAPGEF2","CASP4","STAP1","USP6NL","RALB","EDN1","NCF1","DTX3L","NRK","PMAIP1","GADD45B","S100A10","NCF1B","CCL18","NCF1C","CCL5","LYN","CSF1","NPM2","TANK","PLSCR1","DENND1B","CASP10","ARHGAP25","TLR3","RASGEF1B","FGF10","TXN","GADD45G","TNF","FLT1","RASGRP1","AZIN2","CCL1","FGD2","CYP27B1","LCP2","PTPRC","CHI3L1","PTAFR","CCL4","NR1H3","NR4A2","FPR2","PSEN2","CASP5","F3","CCL2","STAT3","NBN","GUCA1A","P2RY12","PAK1","SRC","TGFB1","ARHGAP17","TBC1D2B","CDC42EP2","ROBO1","CCL19","CDKN1A","AKIRIN2","PDGFRA","GM2A","DUSP5","PTPN1","LPAR1","NCF2","GAS6","CCL3","RGS1","CX3CL1","PRELID1","CFLAR","RGS9","TCIM","BIRC7","CASP1","NKX3-1","SRCIN1","PPARGC1B","SEMA4D","BBC3","PLCB1","ELMOD1","PDGFB","NAPA","SMAD3","LMF1","BAK1","NUPR1","MAP3K8","RFK","NGF","LILRA5","EDNRA","ARHGEF11","S100A1","CXCL1","RINL","TLR4","AGAP2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_HORMONE_METABOLIC_PROCESS","pval":0.59539,"padj":0.94465,"ES":0.80981,"NES":1.02618,"nMoreExtreme":34675,"size":13,"leadingEdge":["TNF","HPN","GATA3","PEBP1"]} {"pathway":"GO_RECEPTOR_CATABOLIC_PROCESS","pval":0.46384,"padj":0.90527,"ES":0.73056,"NES":1.02608,"nMoreExtreme":30237,"size":30,"leadingEdge":["DTX3L","TGFB1","UVRAG","PTPN1","AP2B1"]} {"pathway":"GO_CELL_MOTILITY","pval":0.37519,"padj":0.89036,"ES":0.56025,"NES":1.02602,"nMoreExtreme":37458,"size":1234,"leadingEdge":["ATP1B2","CD40","CD74","CD274","LRRK2","CXCL11","PDE4B","TBX21","CXCL10","PSTPIP2","CEACAM1","CCL13","AMOT","HGF","SELL","CXCL9","CHRD","PADI2","JAK2","AGT","ONECUT2","CCL7","MCOLN2","VCAM1","ICAM1","HSD3B7","MDGA1","KLF4","CCL15","IFITM1","TNFSF18","PML","CCL8","ZC3H12A","CCRL2","P2RX4","RAPGEF2","STAP1","ENPP2","TMSB10","EDN1","VEGFC","MIR503","FAM107A","IL1RN","DYSF","GLIPR2","SDC3","SLAMF8","PTGER4","CCL18","CCL5","LYN","IL12A","GLUL","TNFAIP6","CSF1","NR4A3","TNFRSF14","PARP9","NRCAM","SOD2","PTPRU","PRKX","TNFAIP3","RND1","ANXA3","CXCL16","NRG4","IL6","FGF10","PLEKHO1","EGR3","SEMA7A","TNF","SOX8","STAT5A","FLT1","SLC8A1","DUSP10","CH25H","MIIP","GPR18","CD47","CAMK1D","SMPD3","CCR5","CCL1","ITGAL","ASCL1","UNC5C","NTN1","CXCL12","IGSF8","PTPRC","PTAFR","DDX58","CCL4","NR4A2","AUTS2","FPR2","ACKR4","F3","CCL2","STAT3","CACNA1I","P2RY12","ITGB7","PAK1","NRG2","PODXL","SRC","TGFB1","SEMA4A","ROBO1","CCL19","CCR6","CXCL8","SCYL3","PDGFRA","ADGRB1","SH3RF1","LPAR1","PTGS2","RIPOR2","NME8","ASTN1","HAS2","CD48","PLPP1","GAS6","CCL3","CX3CL1","FOXC1","TNS3","AP1AR","GATA3","NFE2L2","SRCIN1","IL33","MIR212","SEMA4D","ELMO2","DAPK2","PLCB1","PDGFB","SMAD3"]} {"pathway":"GO_REGULATION_OF_PROTEIN_TARGETING","pval":0.43363,"padj":0.90066,"ES":0.64254,"NES":1.02576,"nMoreExtreme":32507,"size":74,"leadingEdge":["LRRK2","NUCB1","KCNE1","PAK1","PARL","STOM"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELL_PROJECTION_ORGANIZATION","pval":0.41656,"padj":0.89503,"ES":0.57469,"NES":1.02569,"nMoreExtreme":38647,"size":321,"leadingEdge":["P2RX7","HGF","AGT","SCARF1","RAPGEF2","ENPP2","C21orf91","LYN","SEMA7A","CAMK1D","NTN1","CXCL12","AUTS2","P2RY12","PAK1","SRC","CDC42EP2","ROBO1","CCL19","RHOQ","LPAR1","RIPOR2","CX3CL1","CFLAR","NFE2L2","SEMA4D","SYT17","SLIT2","NGF","RUFY3","COBL","HAP1","LIMK1","PTN","WNT1","HDAC4","MAP6"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION","pval":0.43465,"padj":0.90066,"ES":0.64456,"NES":1.02564,"nMoreExtreme":32435,"size":72,"leadingEdge":["CXCL9","FLT3LG","EDN1","SOD2","TGFB1","ADGRB1","RIPOR2","CD53","BOC","FLOT1","TBX1","PROX1","MAPK11","SMARCD3","EHD1"]} {"pathway":"GO_LEUKOCYTE_HOMEOSTASIS","pval":0.43395,"padj":0.90066,"ES":0.64163,"NES":1.02559,"nMoreExtreme":32585,"size":75,"leadingEdge":["CD74","P2RX7","PDE4B","HCAR2","TNFSF13B","BCL2L11","JAK3","PMAIP1","LYN","TNFAIP3","IL6","SH2B2","TGFB1","IL2RA","SPTA1","BAK1","FCER1G"]} {"pathway":"GO_RESPONSE_TO_AMINO_ACID","pval":0.42871,"padj":0.89886,"ES":0.6249,"NES":1.02526,"nMoreExtreme":33451,"size":96,"leadingEdge":["SOCS1","ICAM1","EDN1","LYN","TNF","GCLC","PDGFRA","RRAGC","ASNS","RRAGD","UBR1","ASS1","MTHFR","PTN"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MYOBLAST_DIFFERENTIATION","pval":0.54183,"padj":0.9293,"ES":0.79274,"NES":1.02519,"nMoreExtreme":32742,"size":17,"leadingEdge":["CXCL9","FLT3LG","RIPOR2","PLCB1","BOC"]} {"pathway":"GO_RESPONSE_TO_PROSTAGLANDIN_D","pval":0.45315,"padj":0.90517,"ES":0.68732,"NES":1.02518,"nMoreExtreme":22771,"size":2,"leadingEdge":["TNC","PTGFR"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INTERLEUKIN_17_PRODUCTION","pval":0.6111,"padj":0.94703,"ES":0.80947,"NES":1.02505,"nMoreExtreme":35249,"size":12,"leadingEdge":["IL15","NOD2","SLAMF6","MYD88","CCL1","TGFB1","PRKCQ"]} {"pathway":"GO_REGULATION_OF_PROTEIN_STABILITY","pval":0.42233,"padj":0.89612,"ES":0.58168,"NES":1.0246,"nMoreExtreme":37883,"size":246,"leadingEdge":["ATP1B2","LRRK2","FAM107A","ANK2","PYHIN1","B4GALT5","SRC","CDKN1A","TRIM21","USP18","SMAD3","FLOT1"]} {"pathway":"GO_POSITIVE_REGULATION_BY_HOST_OF_VIRAL_TRANSCRIPTION","pval":0.54266,"padj":0.92999,"ES":0.79214,"NES":1.02442,"nMoreExtreme":32792,"size":17,"leadingEdge":["HPN","GTF2B","CTDP1"]} {"pathway":"GO_TRANSITION_BETWEEN_FAST_AND_SLOW_FIBER","pval":0.65674,"padj":0.94878,"ES":0.78311,"NES":1.02436,"nMoreExtreme":35697,"size":7,"leadingEdge":["MYH7","TNNT1"]} {"pathway":"GO_REGULATION_OF_CELLULAR_COMPONENT_SIZE","pval":0.42082,"padj":0.89612,"ES":0.57371,"NES":1.02428,"nMoreExtreme":39071,"size":323,"leadingEdge":["P2RX7","PLEK","ATP13A2","SLC12A3","SPTBN4","ICAM1","SCIN","TMSB10","EDN1","NRCAM","SEMA7A","SLC12A7","NTN1","CXCL12","ACTR3C","PAK1","SEMA4A","CDC42EP2","KCNMA1","ACTN2","MAP2","AP1AR","SEMA4D","SPTA1","SLIT2","TRIM46","NGF"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE","pval":0.46645,"padj":0.90732,"ES":0.72926,"NES":1.02426,"nMoreExtreme":30407,"size":30,"leadingEdge":["CD74","MUC1","CXCL12","KDM1A"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_DENDRITE_MORPHOGENESIS","pval":0.62697,"padj":0.94878,"ES":0.80876,"NES":1.02414,"nMoreExtreme":35799,"size":11,"leadingEdge":["RAPGEF2","NFATC4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_GLUCONEOGENESIS","pval":0.62706,"padj":0.94878,"ES":0.80863,"NES":1.02398,"nMoreExtreme":35804,"size":11,"leadingEdge":["DGAT2","PTPN2","SIRT1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MOLECULAR_FUNCTION","pval":0.37269,"padj":0.89036,"ES":0.55874,"NES":1.02379,"nMoreExtreme":37243,"size":1507,"leadingEdge":["ATP1B2","PSME2","AIM2","CD40","CD74","P2RX7","SOCS1","LRRK2","GCH1","ITK","NOD2","CCL13","PLEK","HGF","RHEBL1","TNFSF10","PSME1","TAGAP","JAK2","AGT","RIPK2","CCL7","FAS","ACSL1","ICAM1","KLF4","BCL2L11","ARAP2","CCL15","VPS9D1","RSU1","TNFSF18","TRIM22","PML","FAM20A","B2M","CCL8","MEFV","RASGRF1","ABCB1","CTSS","RAPGEF2","CASP4","STAP1","CARD16","USP6NL","RALB","EDN1","NCF1","DTX3L","NRK","PMAIP1","GADD45B","ANK2","TRIM31","S100A10","NCF1B","CCL18","NCF1C","CCL5","LYN","PYHIN1","SYNGR3","CSF1","NPM2","TANK","PARP9","PLSCR1","IRF4","DENND1B","ANXA3","RNF207","MYD88","CASP10","ARHGAP25","STAC3","IL6","TLR3","RASGEF1B","FGF10","TXN","GADD45G","NFKB2","TNF","FLT1","RBCK1","RASGRP1","CAMK1D","AZIN2","CCL1","FGD2","CYP27B1","LCP2","PTPRC","CHI3L1","PTAFR","DDX58","CCL4","NR1H3","NR4A2","FPR2","PSEN2","CASP5","F3","CCL2","STAT3","NBN","GUCA1A","P2RY12","PAK1","SRC","TGFB1","ARHGAP17","TBC1D2B","CDC42EP2","ROBO1","CCL19","CDKN1A","AKIRIN2","PDGFRA","TRIM21","GM2A","DUSP5","PTPN1","ACTN2","LPAR1","RIPOR2","NCF2","GAS6","CCL3","RGS1","CX3CL1","FOXC1","PRELID1","TRIM25","CFLAR","RGS9","TCIM","GATA3","BIRC7","CASP1","NKX3-1","SRCIN1","PPARGC1B","SEMA4D","HERPUD1","BBC3","PLCB1","CLIC2","ELMOD1","PDGFB","NAPA","SMAD3","TRAF1","LMF1","SPTA1","GLRX","BAK1","NUPR1","MAP3K8","NFAM1","RFK","NGF","LILRA5","EDNRA","ARHGEF11","S100A1","ARID5B","FLOT1","ARC","CXCL1","RINL","TLR4","AGAP2","IL18RAP","GTF2B"]} {"pathway":"GO_PARTURITION","pval":0.59793,"padj":0.94558,"ES":0.8076,"NES":1.02338,"nMoreExtreme":34823,"size":13,"leadingEdge":["CYP1A1","EDN1","NRK","MAFF","PLA2G4C","PTAFR"]} {"pathway":"GO_POSITIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS","pval":0.45823,"padj":0.90517,"ES":0.71047,"NES":1.0233,"nMoreExtreme":30541,"size":35,"leadingEdge":["CD274","ACOD1","OPTN","RIPK2","DDX60","IL12A","CD226","DHX58"]} {"pathway":"GO_REGULATION_OF_GLUCONEOGENESIS","pval":0.45825,"padj":0.90517,"ES":0.71045,"NES":1.02327,"nMoreExtreme":30542,"size":35,"leadingEdge":["DGAT2","PTPN2","SIK1","PDK2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS","pval":0.4224,"padj":0.89612,"ES":0.56675,"NES":1.02315,"nMoreExtreme":40401,"size":442,"leadingEdge":["GBP5","AIM2","P2RX7","PLEK","ATP13A2","AGT","ICAM1","BCL2L11","SCIN","RALB","EDN1","PMAIP1","S100A10","PPM1E","TRABD2A","TNF","CD47","SMPD3","ACTR3C","AUTS2","P2RY12","PAK1","SRC","TGFB1","SEMA4A","CDC42EP2","CCL19","RHOQ","ADGRB1","LPAR1","TPPP","RIPOR2","CX3CL1","AP1AR","SEMA4D","SMAD3"]} {"pathway":"GO_LYMPHOCYTE_CHEMOTAXIS","pval":0.44687,"padj":0.90517,"ES":0.67898,"NES":1.02305,"nMoreExtreme":31189,"size":47,"leadingEdge":["CXCL11","CXCL10","CCL13","PADI2","CCL7","HSD3B7","CCL15","CCL8","CCL18","CCL5","CXCL16","CH25H","CCL1","CCL4","CCL2","CCL19","GAS6","CCL3","CX3CL1"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE","pval":0.42687,"padj":0.8986,"ES":0.58348,"NES":1.02296,"nMoreExtreme":37839,"size":225,"leadingEdge":["GBP1","VAMP5","OPTN","SPTBN4","RAPGEF2","ANK2","S100A10","FYB1","TMEM150A","STAC3","TNF","TGFB1","RHOQ","ACTN2","PLEKHF1","AMN","GAS6","RILPL1","STX3","FCER1G","FLOT1","ZDHHC23"]} {"pathway":"GO_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS","pval":0.45846,"padj":0.90517,"ES":0.70679,"NES":1.02255,"nMoreExtreme":30711,"size":36,"leadingEdge":["IL31RA","HLA-E","ICAM1","C3","LTA","TNF","RASGRP1","IL2RA","GATA3","FCER1G"]} {"pathway":"GO_POSITIVE_REGULATION_OF_VASCULAR_SMOOTH_MUSCLE_CELL_PROLIFERATION","pval":0.463,"padj":0.90517,"ES":0.71655,"NES":1.02238,"nMoreExtreme":30605,"size":33,"leadingEdge":["JAK2","AGT","EDN1","NR4A3","TNF","PAK1","PDGFB"]} {"pathway":"GO_ORGANIC_ACID_BIOSYNTHETIC_PROCESS","pval":0.42896,"padj":0.89886,"ES":0.58369,"NES":1.02237,"nMoreExtreme":37943,"size":221,"leadingEdge":["IDO1","CD74","CEACAM1","CYP1A1","HSD3B7","OSBPL6","EDN1","DHRS9","GGT5","GLUL","KYNU","CBR1","CH25H","PLA2G4A","NR1H3","ELOVL7","KMO","ACSS1","PTGS2","ACSM5","ASNS","ERLIN1","GLS","SEPHS2","INSIG2","ASS1","MTHFR","CBSL","ALDH1A2","SDS","LPGAT1","PROX1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_RECEPTOR_SIGNALING_PATHWAY_VIA_STAT","pval":0.53498,"padj":0.92816,"ES":0.78493,"NES":1.02226,"nMoreExtreme":32548,"size":18,"leadingEdge":["SOCS1","PARP14","SOCS3","PTPN2"]} {"pathway":"GO_CARDIAC_CONDUCTION","pval":0.43469,"padj":0.90066,"ES":0.61859,"NES":1.02225,"nMoreExtreme":34357,"size":103,"leadingEdge":["ATP1B2","AGT","KCNJ2","CAMK2D","SPTBN4","SRI","NPR1","GJD3","ANK2","KCNE5","RNF207","SLC8A1","KCNE1"]} {"pathway":"GO_INNER_DYNEIN_ARM_ASSEMBLY","pval":0.65678,"padj":0.94878,"ES":0.79193,"NES":1.02216,"nMoreExtreme":36188,"size":8,"leadingEdge":["DNAAF1","DNAH1"]} {"pathway":"GO_OSTEOCLAST_PROLIFERATION","pval":0.65765,"padj":0.94878,"ES":0.78136,"NES":1.02208,"nMoreExtreme":35746,"size":7,"leadingEdge":["FLT3LG","CSF1","TNFAIP3","OCSTAMP"]} {"pathway":"GO_REGULATION_OF_TRANSPORTER_ACTIVITY","pval":0.43141,"padj":0.89981,"ES":0.58819,"NES":1.02192,"nMoreExtreme":37453,"size":194,"leadingEdge":["ATP1B2","PDE4B","CAMK2D","SRI","RASGRF1","ABCB1","CTSS","ANK2","DYSF","SYNGR3","KCNE5","ANXA3","RNF207","STAC3","JPH4","GEM","PTAFR","KCNE1","ACTN2","RGS9","MIR212","CLIC2","GLRX","KCNE1B","STOM","SHISA7","S100A1","ARC","MAPK8IP2","GPR35","HAP1"]} {"pathway":"GO_CAMERA_TYPE_EYE_PHOTORECEPTOR_CELL_DIFFERENTIATION","pval":0.62869,"padj":0.94878,"ES":0.80692,"NES":1.02182,"nMoreExtreme":35897,"size":11,"leadingEdge":["SOX8","RORB","PTN","PROM1"]} {"pathway":"GO_ENTRAINMENT_OF_CIRCADIAN_CLOCK","pval":0.49785,"padj":0.91907,"ES":0.75778,"NES":1.02118,"nMoreExtreme":31323,"size":23,"leadingEdge":["ARNTL2","PML","SIK1","FBXL3"]} {"pathway":"GO_CELLULAR_DEFENSE_RESPONSE","pval":0.46189,"padj":0.90517,"ES":0.70877,"NES":1.02084,"nMoreExtreme":30785,"size":35,"leadingEdge":["ITK","CXCL9","LGALS3BP","NCF1","HLA-G","CCR5","MNDA","CCR6","NCF2"]} {"pathway":"GO_RESPONSE_TO_LEUKEMIA_INHIBITORY_FACTOR","pval":0.43825,"padj":0.90126,"ES":0.62706,"NES":1.02046,"nMoreExtreme":33761,"size":89,"leadingEdge":["SNX10","PADI2","ICAM1","KLF4","PML","VEGFC","SBNO2","MRAS","TEX14","PFKP","BSPRY","SOCS3","TRIM25","ILDR1","ARID5B"]} {"pathway":"GO_RESPONSE_TO_RETINOIC_ACID","pval":0.44099,"padj":0.90126,"ES":0.6314,"NES":1.02045,"nMoreExtreme":33635,"size":83,"leadingEdge":["CD38","KLF4","IGF2R","LYN","NCOA1","ASCL1","MICB","RORB","ALDH1A2","TBX1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_IN_ABSENCE_OF_LIGAND","pval":0.4726,"padj":0.90882,"ES":0.72635,"NES":1.02016,"nMoreExtreme":30808,"size":30,"leadingEdge":["IL7","FGF10","TNF","IFI6","MCL1","CX3CL1","IL1A","FYN"]} {"pathway":"GO_RENAL_VESICLE_DEVELOPMENT","pval":0.55994,"padj":0.93517,"ES":0.79407,"NES":1.02011,"nMoreExtreme":33541,"size":16,"leadingEdge":["STAT1","SOX8","SALL1"]} {"pathway":"GO_ADULT_LOCOMOTORY_BEHAVIOR","pval":0.44929,"padj":0.90517,"ES":0.66613,"NES":1.02011,"nMoreExtreme":31901,"size":53,"leadingEdge":["KCNJ10","SPTBN4","CTNS","CXCL12","NR4A2","SEZ6L","NPC1"]} {"pathway":"GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE","pval":0.43943,"padj":0.90126,"ES":0.62105,"NES":1.01996,"nMoreExtreme":34345,"size":97,"leadingEdge":["CD74","BCL2A1","BCL2L11","MUC1","PML","TMEM109","POLB","TNF","CXCL12","IKBKE","MCL1","BAK1","NUPR1","HIC1","FNIP2"]} {"pathway":"GO_ANAPHASE_PROMOTING_COMPLEX_DEPENDENT_CATABOLIC_PROCESS","pval":0.44309,"padj":0.90252,"ES":0.63521,"NES":1.01971,"nMoreExtreme":33468,"size":78,"leadingEdge":["PSME2","PSMB9","PSME1","PSMB10","PSMB8","PSMA4","PSMA2","PSMA5"]} {"pathway":"GO_MODULATION_OF_EXCITATORY_POSTSYNAPTIC_POTENTIAL","pval":0.47002,"padj":0.9079,"ES":0.71817,"NES":1.01926,"nMoreExtreme":30909,"size":32,"leadingEdge":["LRRK2","PRKCZ"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION","pval":0.48331,"padj":0.91689,"ES":0.73781,"NES":1.01914,"nMoreExtreme":31076,"size":27,"leadingEdge":["CXCL10","BHLHE41","TRIM72","PAK1","CFLAR","HDAC4"]} {"pathway":"GO_NERVE_DEVELOPMENT","pval":0.45096,"padj":0.90517,"ES":0.66381,"NES":1.01902,"nMoreExtreme":32099,"size":54,"leadingEdge":["EGR2","VCAM1","TIFAB","LPAR1","NGF","TBX1","NPTX1","NEUROG1","SEMA3F","SIX1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL","pval":0.46061,"padj":0.90517,"ES":0.69521,"NES":1.01884,"nMoreExtreme":31285,"size":39,"leadingEdge":["P2RX7","CXCL11","CXCL10","CXCL9","SRI","P2RX4","CX3CL1","BAK1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_COFACTOR_METABOLIC_PROCESS","pval":0.64431,"padj":0.94878,"ES":0.76191,"NES":1.01881,"nMoreExtreme":34579,"size":6,"leadingEdge":["CTNS","STAT3","FYN"]} {"pathway":"GO_SOMATIC_RECOMBINATION_OF_IMMUNOGLOBULIN_GENE_SEGMENTS","pval":0.4541,"padj":0.90517,"ES":0.67608,"NES":1.01868,"nMoreExtreme":31694,"size":47,"leadingEdge":["CD40","TBX21","POLB","BCL6","PARP3","PTPRC","NBN","TGFB1","CCR6","LIG4"]} {"pathway":"GO_LOCOMOTION","pval":0.40562,"padj":0.89503,"ES":0.55599,"NES":1.01863,"nMoreExtreme":40526,"size":1409,"leadingEdge":["ATP1B2","CD40","CD74","CD274","LRRK2","CXCL11","PDE4B","TBX21","CXCL10","PSTPIP2","CEACAM1","CCL13","AMOT","HGF","SELL","CXCL9","CHRD","EGR2","PADI2","JAK2","SUCNR1","AGT","ONECUT2","CCL7","MCOLN2","TYMP","VCAM1","SPTBN4","ICAM1","HSD3B7","MDGA1","KLF4","CCL15","IFITM1","TNFSF18","PML","CCL8","ZC3H12A","CCRL2","P2RX4","RAPGEF2","STAP1","ENPP2","TMSB10","EDN1","VEGFC","MIR503","FAM107A","IL1RN","TRIM31","DYSF","GLIPR2","SDC3","SLAMF8","CHMP4C","PTGER4","CCL18","CCL5","LYN","IL12A","GLUL","TNFAIP6","CSF1","NR4A3","TNFRSF14","PARP9","NRCAM","SOD2","PTPRU","PRKX","TNFAIP3","RND1","ANXA3","CXCL16","NRG4","IL6","FGF10","PLEKHO1","EGR3","SEMA7A","TNF","SOX8","STAT5A","FLT1","SLC8A1","DUSP10","CH25H","MIIP","GPR18","CD47","CAMK1D","SMPD3","CCR5","CCL1","ITGAL","ASCL1","UNC5C","NTN1","CXCL12","IGSF8","PTPRC","PTAFR","DDX58","CCL4","NR4A2","AUTS2","FPR2","ACKR4","F3","CCL2","STAT3","CACNA1I","P2RY12","PTPN2","ITGB7","PAK1","NRG2","PODXL","SRC","TGFB1","SEMA4A","ROBO1","CCL19","CCR6","CXCL8","SCYL3","PDGFRA","TRIM21","ISL2","ADGRB1","SH3RF1","LPAR1","PLGRKT","PTGS2","RIPOR2","NME8","ASTN1","HAS2","CD48","PLPP1","GAS6","CCL3","CX3CL1","FOXC1","TNS3","TRIM25","AP1AR","EPHA10","GATA3","NFE2L2","SRCIN1","IL33","MIR212","SEMA4D","ELMO2","DAPK2","PLCB1","PDGFB","SMAD3"]} {"pathway":"GO_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION","pval":0.54971,"padj":0.93134,"ES":0.78756,"NES":1.01849,"nMoreExtreme":33218,"size":17,"leadingEdge":["CD74","HLA-DOA","NOD2","HLA-DOB","TAPBPL","CCL19"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_1_SECRETION","pval":0.61675,"padj":0.94878,"ES":0.80425,"NES":1.01844,"nMoreExtreme":35575,"size":12,"leadingEdge":["PML","ZC3H12A","CARD17","CARD16","TNFAIP3","GAS6","IL1R2"]} {"pathway":"GO_REGULATION_OF_PLASMA_LIPOPROTEIN_PARTICLE_LEVELS","pval":0.4505,"padj":0.90517,"ES":0.6516,"NES":1.0179,"nMoreExtreme":32810,"size":62,"leadingEdge":["AGT","SOAT1","DGAT2","LIPG","AMN","LMF1","NPC1","EHD1"]} {"pathway":"GO_EXPORT_ACROSS_PLASMA_MEMBRANE","pval":0.52186,"padj":0.9256,"ES":0.77068,"NES":1.01746,"nMoreExtreme":32258,"size":20,"leadingEdge":["ATP1B2","KCNE5","SLC8A1","KCNE1","KCNE1B"]} {"pathway":"GO_PROTEIN_CHROMOPHORE_LINKAGE","pval":0.49532,"padj":0.91907,"ES":0.69039,"NES":1.01714,"nMoreExtreme":25321,"size":3,"leadingEdge":["CRY1","OPN3","CRY2"]} {"pathway":"GO_FOREBRAIN_DORSAL_VENTRAL_PATTERN_FORMATION","pval":0.45784,"padj":0.90517,"ES":0.68187,"NES":1.01705,"nMoreExtreme":23007,"size":2,"leadingEdge":["GLI3","TTC21B"]} {"pathway":"GO_PROTEIN_TRIMERIZATION","pval":0.45862,"padj":0.90517,"ES":0.68165,"NES":1.01702,"nMoreExtreme":31730,"size":44,"leadingEdge":["CD74","STEAP4","TRIM22","HLA-G","TRIM21"]} {"pathway":"GO_LEUKOCYTE_ADHESION_TO_VASCULAR_ENDOTHELIAL_CELL","pval":0.48155,"padj":0.91676,"ES":0.73179,"NES":1.01696,"nMoreExtreme":31106,"size":28,"leadingEdge":["SELL","VCAM1","ICAM1","KLF4","TNF","CXCL12","PTAFR","ITGB7"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION","pval":0.44925,"padj":0.90517,"ES":0.63137,"NES":1.01647,"nMoreExtreme":34091,"size":80,"leadingEdge":["RIPK2","IL6","TXN","TNF","PAK1","TGFB1","PTGS2","GAS6","FNIP2","SH2D3C"]} {"pathway":"GO_APOPTOTIC_MITOCHONDRIAL_CHANGES","pval":0.4459,"padj":0.90517,"ES":0.61157,"NES":1.0163,"nMoreExtreme":35571,"size":109,"leadingEdge":["HGF","TNFSF10","BCL2L11","AIFM2","IFIT2","PMAIP1","SOD2","ATG3","GCLC","IFI6","PRELID1","BBC3","BAK1"]} {"pathway":"GO_GLYCEROLIPID_METABOLIC_PROCESS","pval":0.44703,"padj":0.90517,"ES":0.58551,"NES":1.01579,"nMoreExtreme":38700,"size":189,"leadingEdge":["PLAAT4","SOCS1","GK","PLEK","PLAAT3","PLA1A","CISH","DGAT2","TMEM150A","PLA2G4C","LPCAT2","DGKG","PLA2G4A","SOCS3","PLCB1","LMF1","PIGY","INSIG2","CPT1A","LPGAT1","MTMR8"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA","pval":0.55295,"padj":0.93341,"ES":0.78536,"NES":1.01565,"nMoreExtreme":33414,"size":17,"leadingEdge":["HGF","PRELID1","IGF1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PLATELET_AGGREGATION","pval":0.65981,"padj":0.94905,"ES":0.78683,"NES":1.01557,"nMoreExtreme":36355,"size":8,"leadingEdge":["CEACAM1","SERPINE2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SYNAPTIC_VESICLE_ENDOCYTOSIS","pval":0.64509,"padj":0.94878,"ES":0.7594,"NES":1.01545,"nMoreExtreme":34621,"size":6,"leadingEdge":["LRRK2","DNM1L"]} {"pathway":"GO_REGULATION_OF_SYNAPTIC_VESICLE_RECYCLING","pval":0.50041,"padj":0.91978,"ES":0.74856,"NES":1.01524,"nMoreExtreme":31691,"size":24,"leadingEdge":["LRRK2","SYT7"]} {"pathway":"GO_METANEPHROS_MORPHOGENESIS","pval":0.50055,"padj":0.91978,"ES":0.74847,"NES":1.01512,"nMoreExtreme":31700,"size":24,"leadingEdge":["STAT1","FGF10","SOX8","PKD1"]} {"pathway":"GO_REGULATION_OF_ISOTYPE_SWITCHING","pval":0.47389,"padj":0.90926,"ES":0.71134,"NES":1.01494,"nMoreExtreme":31325,"size":33,"leadingEdge":["CD40","TBX21","BCL6","PARP3","PTPRC","TGFB1"]} {"pathway":"GO_PROTEIN_PHOSPHORYLATION","pval":0.42041,"padj":0.89612,"ES":0.55383,"NES":1.01493,"nMoreExtreme":42025,"size":1612,"leadingEdge":["IL31RA","PSME2","CD40","GBP1","CD74","P2RX7","SOCS1","LRRK2","ITK","PSMB9","IL15","CXCL10","NOD2","CEACAM1","CCL13","HGF","ATP13A2","PSME1","IL3RA","BANK1","ATF3","LMTK2","LIMK2","JAK2","PSMB10","AGT","PIM1","RIPK2","TLR8","STAT2","CCL7","FAS","ACSL1","PSMB8","CAMK2D","SPTBN4","ICAM1","KLF4","CCL15","FLT3LG","TNFSF18","CD80","PML","FAM20A","CSF2RB","CCL8","C3","SCIMP","RASGRF1","ZC3H12A","JAK3","CYLD","RAPGEF2","STAP1","NPR1","IL12RB2","ENPP2","RALB","BTN2A2","EDN1","VEGFC","SLAMF1","NCF1","NRK","MIR503","MVP","IL1RN","GADD45B","STAP2","GLIPR2","PTGER4","PPM1E","CCL18","CCL5","LYN","IL12A","DTNBP1","PARP14","TLR7","CDKL1","CSF1","VRK2","TNFRSF14","PARP9","IL7","PRKX","GAREM1","TNFAIP3","NRG4","IL6","TLR3","FGF10","IL2RG","TXN","AURKC","GADD45G","SEMA7A","NOTCH2","TNF","TEX14","PSMA4","FLT1","PSMA2","ADM2","CUL1","DUSP10","RASGRP1","CAMK1D","SMPD3","CCR5","CCL1","FGD2","LCP2","PTPRC","CHI3L1","CCL4","FPR2","SIK1B","SIK3","SOCS3","CCL2","STAT3","NBN","PTPN2","PAK1","NRG2","NUAK2","SRC","TGFB1","ROBO1","IL2RA","CCL19","CDKN1A","UVRAG","PSMA5","SCYL3","PRDX1","PDGFRA","ADAR","IKBKE","DUSP5","CDKN1C","PTPN1","ACTN2","PKHD1","CCNL1","SH3RF1","LPAR1","PTGS2","GAS6","CCL3","CX3CL1","CFLAR","TCIM","EPHA10","BIRC7","NKX3-1","SRCIN1","MIR212","SEMA4D","CCNA1","SPINK1","DAPK2","NEK11","PLCB1"]} {"pathway":"GO_REGULATION_OF_CELL_SUBSTRATE_ADHESION","pval":0.44875,"padj":0.90517,"ES":0.58678,"NES":1.01465,"nMoreExtreme":38582,"size":180,"leadingEdge":["GBP1","JAK2","ONECUT2","RSU1","MIR503","FAM107A","S100A10","BCL6","CSF1","SRC","GPM6B","HAS2","CX3CL1","AP1AR","SMAD3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_PRODUCTION","pval":0.47045,"padj":0.9079,"ES":0.70122,"NES":1.0145,"nMoreExtreme":31514,"size":36,"leadingEdge":["CD40","TBX21","HLA-E","IL6","PTPRC","TGFB1","IL33"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_KERATINOCYTE_DIFFERENTIATION","pval":0.45946,"padj":0.90517,"ES":0.67996,"NES":1.0142,"nMoreExtreme":23088,"size":2,"leadingEdge":["MSX2","SRSF6"]} {"pathway":"GO_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY","pval":0.48622,"padj":0.91689,"ES":0.72954,"NES":1.01383,"nMoreExtreme":31408,"size":28,"leadingEdge":["IGF2R","TRIM72","NKX3-1","PLCB1","WNT1"]} {"pathway":"GO_REGULATION_OF_GTPASE_ACTIVITY","pval":0.4523,"padj":0.90517,"ES":0.56211,"NES":1.01362,"nMoreExtreme":43115,"size":427,"leadingEdge":["CD40","LRRK2","CCL13","AMOT","TAGAP","CCL7","ICAM1","ARAP2","CCL15","VPS9D1","RSU1","CCL8","RASGRF1","RAPGEF2","USP6NL","S100A10","BCL6","CCL18","CCL5","DENND1B","ARHGAP25","RASGEF1B","RASGRP1","CCL1","FGD2","RHOH","CCL4","CCL2","ARHGAP17","TBC1D2B","CDC42EP2","CCL19","STMN3","CCL3","RGS1","CX3CL1","RGS9","SEMA4D","PLCB1","ELMOD1","FGD6","SLIT2"]} {"pathway":"GO_MONOCARBOXYLIC_ACID_TRANSPORT","pval":0.45138,"padj":0.90517,"ES":0.61271,"NES":1.01358,"nMoreExtreme":35747,"size":104,"leadingEdge":["SLC6A12","P2RX7","CEACAM1","ACSL1","P2RX4","EDN1","SLC27A3","SLC51A","PLA2G4A","NCOA1","MFSD2A"]} {"pathway":"GO_CELL_CHEMOTAXIS","pval":0.4515,"padj":0.90517,"ES":0.57652,"NES":1.01356,"nMoreExtreme":40317,"size":237,"leadingEdge":["CD74","CXCL11","PDE4B","CXCL10","CCL13","HGF","CXCL9","PADI2","CCL7","VCAM1","HSD3B7","CCL15","CCL8","CCRL2","P2RX4","STAP1","EDN1","VEGFC","IL1RN","DYSF","SLAMF8","CCL18","CCL5","LYN","IL12A","CSF1","CXCL16","IL6","EGR3","FLT1","CH25H","GPR18","CAMK1D","CCR5","CCL1","CXCL12","CCL4","FPR2","ACKR4","CCL2","CCL19","CCR6","CXCL8","PDGFRA","LPAR1","RIPOR2","GAS6","CCL3","CX3CL1","ELMO2","DAPK2","PDGFB"]} {"pathway":"GO_GOLGI_ORGANIZATION","pval":0.45063,"padj":0.90517,"ES":0.60263,"NES":1.01352,"nMoreExtreme":36711,"size":125,"leadingEdge":["LRRK2","OPTN","USP6NL","TICAM2","PDE4DIP","VCPIP1","STX17","GCC2","RAB43"]} {"pathway":"GO_POSITIVE_REGULATION_OF_GLYCOLYTIC_PROCESS","pval":0.57989,"padj":0.94163,"ES":0.79322,"NES":1.01345,"nMoreExtreme":34458,"size":15,"leadingEdge":["P2RX7","ESRRB","MLXIPL"]} {"pathway":"GO_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS","pval":0.4512,"padj":0.90517,"ES":0.55502,"NES":1.01329,"nMoreExtreme":44649,"size":787,"leadingEdge":["GBP5","AIM2","P2RX7","LRRK2","PLEK","ATP13A2","AGT","SPTBN4","ICAM1","MDGA1","BCL2L11","PRRT2","MEFV","PARP10","CYLD","RAPGEF2","STAP1","SCIN","RALB","TMSB10","EDN1","FAM107A","PMAIP1","S100A10","COLQ","CHMP4C","PTGER4","PPM1E","TRABD2A","CDKL1","TNF","CD47","SMPD3","FARP2","NTN1","ACTR3C","ATG3","AUTS2","P2RY12","PAK1","TRIM9","PODXL","RUNX1","SRC","TGFB1","SEMA4A","NTNG2","CDC42EP2","CCL19","RHOQ","MAP2","ADGRB1","LPAR1","TPPP","GPM6B","RIPOR2","HAS2","CX3CL1","AP1AR","SEMA4D","NAPA","SMAD3","SPTA1","SLIT2"]} {"pathway":"GO_ACTIVATION_OF_PHOSPHOLIPASE_C_ACTIVITY","pval":0.52027,"padj":0.9256,"ES":0.762,"NES":1.013,"nMoreExtreme":32379,"size":21,"leadingEdge":["ITK","AGT","P2RY12","LPAR1","EDNRA"]} {"pathway":"GO_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS","pval":0.45304,"padj":0.90517,"ES":0.62243,"NES":1.01294,"nMoreExtreme":34901,"size":89,"leadingEdge":["LRRK2","HGF","AGT","TYMP","EDN1","PTAFR","SRC","CCL3","ACPP","SHISA7","GPR35","NPTX1"]} {"pathway":"GO_PROTEIN_TETRAMERIZATION","pval":0.45238,"padj":0.90517,"ES":0.60675,"NES":1.01281,"nMoreExtreme":36357,"size":115,"leadingEdge":["GBP5","CD74","DPYS","KCNJ2","S100A10","CCL5","SOD2","DECR1","ACTN2","ACPP","GLS"]} {"pathway":"GO_CYCLIC_NUCLEOTIDE_CATABOLIC_PROCESS","pval":0.64883,"padj":0.94878,"ES":0.79754,"NES":1.0125,"nMoreExtreme":36623,"size":10,"leadingEdge":["PDE4B","PDE4A"]} {"pathway":"GO_ACTIVATION_OF_MAPK_ACTIVITY","pval":0.45468,"padj":0.90517,"ES":0.59847,"NES":1.01184,"nMoreExtreme":37379,"size":133,"leadingEdge":["CD74","P2RX7","LRRK2","NOD2","HGF","RIPK2","FGF10","TNF","PTPRC","CCL19","DUSP5","PTPN1","LPAR1","BIRC7"]} {"pathway":"GO_HOMEOSTATIC_PROCESS","pval":0.44185,"padj":0.90177,"ES":0.55218,"NES":1.01172,"nMoreExtreme":44150,"size":1442,"leadingEdge":["ATP1B2","IL31RA","CD40","CD74","P2RX7","LRRK2","SNX10","CXCL11","CD38","IL15","PDE4B","CXCL10","NOD2","CCL13","ATP13A2","SLC31A2","CXCL9","STAT1","KCNJ10","HCAR2","JAK2","SUCNR1","AGT","STEAP4","SLC12A3","TNFSF13B","CCL7","ACSL1","XRN1","KCNJ2","MCOLN2","CAMK2D","ICAM1","SIDT2","BCL2L11","CCL15","TGM2","FLT3LG","SOAT1","PML","FAM20A","SRI","B2M","CCL8","CCRL2","JAK3","CYLD","P2RX4","RAB20","NPR1","GRAMD1B","EDN1","NCF1","PIWIL4","PMAIP1","SCO2","SLC25A28","ANK2","TTC39B","DGAT2","MT2A","SLAMF8","POLB","PTGER4","DYNLT1","BCL6","CCL5","LYN","CSF1","NR4A3","PARP3","IL7","SOD2","IRF4","TNFAIP3","IL6","TXN","MT1M","JPH4","DECR1","GADD45G","TNF","PTGER2","SLC8A1","VGF","CUL1","GPR18","F2RL2","MT1E","CCR5","CCL1","SLC12A7","CXCL12","CYP27B1","PTPRC","SLC4A10","LIPG","NR1H3","AUTS2","FPR2","ACKR4","CCL2","SH2B2","TMTC2","STAT3","NBN","PTPN2","ANGPTL4","GCLC","SRC","TGFB1","KCNMA1","IL2RA","CCL19","CCR6","UCP2","PRDX1","MT1H","ATP6V1A","PDGFRA","C19orf12","STN1","HVCN1","P2RY2","IFI6","GRINA","MCL1","ISG15","PKHD1","LPAR1","PTGS2","NME8","HAS2","NCF2","GAS6","CCL3","CX3CL1","FOXC1","GATA3","CKB","MT1G","NFE2L2","PPARGC1B","LIN28A","HERPUD1","PLCB1","CLIC2","SLC8A2","NADK","SMAD3","RAB38","RAB39A","SPTA1","ZFP36","GLRX","BAK1","IL1A"]} {"pathway":"GO_REGULATION_OF_TRANS_SYNAPTIC_SIGNALING","pval":0.45699,"padj":0.90517,"ES":0.56581,"NES":1.0116,"nMoreExtreme":42603,"size":336,"leadingEdge":["LRRK2","CD38","EGR2","GRIN3A","KCNJ10","JAK2","AGT","GRM8","PRRT2","RASGRF1","RAPGEF2","MCTP2","EDN1","FAM107A","DTNBP1","GLUL","AKAP7","JPH4","TNF","CCL2","KMO","STAT3","SRC","NTNG2","AKAP12","GUCY1A1","ADGRB1","PTGS2","CX3CL1","GUCY1B1","PLCB1","SLC8A2","NAPA","STX3","RNF19A","NGF","SHISA7","FLOT1","ARC","RAPSN","MAPK8IP2","CLSTN3","HAP1","ADORA2A","PTN","LZTS1","NPTX1"]} {"pathway":"GO_DETOXIFICATION","pval":0.45751,"padj":0.90517,"ES":0.62267,"NES":1.01125,"nMoreExtreme":35157,"size":87,"leadingEdge":["GCH1","GSTK1","MT2A","SOD2","TXN","MT1M","TNF","MT1E","PRDX1","MT1H","PTGS2","MT1G","NFE2L2","CLIC2"]} {"pathway":"GO_ALTERNATIVE_MRNA_SPLICING_VIA_SPLICEOSOME","pval":0.46047,"padj":0.90517,"ES":0.63989,"NES":1.01102,"nMoreExtreme":34024,"size":68,"leadingEdge":["RBM11","RBM5"]} {"pathway":"GO_C21_STEROID_HORMONE_METABOLIC_PROCESS","pval":0.50248,"padj":0.91978,"ES":0.74042,"NES":1.0104,"nMoreExtreme":32009,"size":25,"leadingEdge":["DHRS9","TSPOAP1","STARD3NL"]} {"pathway":"GO_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORT","pval":0.4583,"padj":0.90517,"ES":0.61577,"NES":1.01028,"nMoreExtreme":35760,"size":96,"leadingEdge":["SLC6A12","KCNJ10","AGT","SLC25A22","SLC7A2","SLC25A30","CPT1A"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_NITROGEN_COMPOUND","pval":0.46371,"padj":0.90527,"ES":0.55759,"NES":1.0102,"nMoreExtreme":44830,"size":510,"leadingEdge":["P2RX7","SOCS1","LRRK2","PDE4B","NOD2","CEACAM1","STAT1","JAK2","AGT","RIPK2","XRN1","VCAM1","ICAM1","KLF4","JAK3","P2RX4","RAPGEF2","CASP4","CASP7","RALB","EDN1","IFIH1","CISH","LYN","NR4A3","TLR3","TNF","STAT5A","SLC8A1","TRIM72","SMPD3","PTAFR","DDX58","NR4A2","KCNE1","FPR2","SOCS3","SH2B2","STAT3","P2RY12","PTPN2","PAK1","GCLC","SRC","TGFB1","CGAS","UCP2","ATP6V1A","PDGFRA","NAMPT","RRAGC","PTPN1","P2RY2","RHOQ","ACTN2","PTGS2","GUCY1B1","CFLAR","RRAGD","AGTRAP","NFE2L2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS","pval":0.45789,"padj":0.90517,"ES":0.60368,"NES":1.01013,"nMoreExtreme":36949,"size":118,"leadingEdge":["CHRD","AGT","ONECUT2","MIR503","HTRA4","CHST11","TGFB1","PTPN1","CFLAR","GATA3","SMAD3","SLIT2","SHISA2","WNT1","EID2"]} {"pathway":"GO_RESPONSE_TO_ENDOGENOUS_STIMULUS","pval":0.45622,"padj":0.90517,"ES":0.55145,"NES":1.00995,"nMoreExtreme":45556,"size":1256,"leadingEdge":["P2RX7","SOCS1","LRRK2","CD38","PDE4B","NOD2","CEACAM1","RXFP1","TNFSF10","ACOD1","CHRD","EGR2","SSTR2","PADI2","STAT1","JAK2","AGT","RIPK2","ONECUT2","ACSL1","XRN1","VCAM1","ICAM1","PAQR8","KLF4","BCL2L11","PML","CTSS","JAK3","P2RX4","RAPGEF2","CASP4","CASP7","EDN1","MIR503","FAM107A","CISH","IL1RN","COMP","PTGER4","CCL5","LYN","EPHX1","NR4A3","CTSL","PTPRU","GAREM1","ANXA3","MYD88","IL6","FGF10","EGR3","HTRA4","CHST11","TNF","PTGER2","STAT5A","SLC8A1","HPN","VGF","TRIM72","HNF4G","SMPD3","NCOA1","ASCL1","CXCL12","PTAFR","NR1H3","NR4A2","KCNE1","FPR2","SOCS3","CCL2","SH2B2","STAT3","P2RY12","PTPN2","PAK1","TRIM71","GCLC","RUNX1","SRC","TGFB1","CCL19","CXCL8","CDKN1A","UCP2","TXNIP","ATP6V1A","PDGFRA","NAMPT","RRAGC","CDKN1C","PTPN1","P2RY2","RHOQ","SORT1","ACTN2","RGMA","CREBRF","PTGS2","HAS2","PLPP1","GPR150","ASNS","FOXC1","CFLAR","RGS9","RRAGD","GATA3","AGTRAP","NKX3-1","NFE2L2","PPARGC1B","MIR212"]} {"pathway":"GO_NEUTROPHIL_HOMEOSTASIS","pval":0.58349,"padj":0.94167,"ES":0.79041,"NES":1.00986,"nMoreExtreme":34672,"size":15,"leadingEdge":["PDE4B","HCAR2","IL6","PIK3CB"]} {"pathway":"GO_MOTOR_LEARNING","pval":0.48603,"padj":0.91689,"ES":0.75765,"NES":1.00984,"nMoreExtreme":24319,"size":1,"leadingEdge":["DKK1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_EXOCYTOSIS","pval":0.462,"padj":0.90517,"ES":0.63459,"NES":1.00977,"nMoreExtreme":34476,"size":72,"leadingEdge":["HLA-F","ATP13A2","CADPS2","SMPD3","PTAFR","CACNA1I","FCER1G","RAB2B"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING","pval":0.46302,"padj":0.90517,"ES":0.63545,"NES":1.00929,"nMoreExtreme":34459,"size":71,"leadingEdge":["HGF","JAK2","AGT","NCF1","CCL5","LYN","TNF","FLT1","PIK3AP1","SRC","PDGFRA","NKX3-1","SEMA4D","PDGFB","PRR5L"]} {"pathway":"GO_REGULATION_OF_ORGANELLE_ASSEMBLY","pval":0.46076,"padj":0.90517,"ES":0.58597,"NES":1.00927,"nMoreExtreme":39307,"size":170,"leadingEdge":["LRRK2","CYLD","RALB","EDN1","CHMP4C","CDKL1","TNF","ATG3","SRC","C9orf72","PROX1","HAP1"]} {"pathway":"GO_TISSUE_MORPHOGENESIS","pval":0.47134,"padj":0.90863,"ES":0.55578,"NES":1.00833,"nMoreExtreme":45753,"size":544,"leadingEdge":["PSME2","PSMB9","CXCL10","CEACAM1","HGF","PSME1","CHRD","STAT1","PSMB10","AGT","PSMB8","KLF4","DNAAF1","TGM2","PML","EDN1","VEGFC","GCNT3","CSF1","NR4A3","PRKX","MYH7","RNF207","CTSZ","FGF10","TNF","SOX8","PSMA4","PSMA2","NTN1","SOCS3","PAK1","TRIM71","PODXL","SRC","TGFB1","ROBO1","PSMA5"]} {"pathway":"GO_MUSCLE_CELL_PROLIFERATION","pval":0.46265,"padj":0.90517,"ES":0.58717,"NES":1.00814,"nMoreExtreme":39211,"size":163,"leadingEdge":["IL15","STAT1","JAK2","AGT","PIM1","KLF4","TGM2","NPR1","EDN1","MIR503","CCL5","IL12A","NR4A3","SOD2","TNFAIP3","IL6","TNF","SMPD3","PTAFR","STAT3","PAK1","CDKN1A","NAMPT","PTGS2","CX3CL1","FOXC1","CFLAR","PDGFB"]} {"pathway":"GO_CYTOLYSIS","pval":0.59782,"padj":0.94558,"ES":0.79209,"NES":1.00801,"nMoreExtreme":35187,"size":14,"leadingEdge":["APOL1","P2RX7","GSDMD","LILRB1","TGFB1","MICB"]} {"pathway":"GO_CELLULAR_MACROMOLECULE_LOCALIZATION","pval":0.45965,"padj":0.90517,"ES":0.54998,"NES":1.00795,"nMoreExtreme":45954,"size":1705,"leadingEdge":["GBP2","GBP5","GBP1","CD74","VAMP5","LRRK2","SNX10","TNFAIP2","AMOT","STX11","ATP13A2","EGR2","OPTN","AGT","IFI27","EXOC3L4","SPTBN4","RTP4","BCL2L11","PML","ZC3H12A","CYLD","ACOT4","RAPGEF2","RAB20","SCIN","SCG3","USP6NL","RALB","TMSB10","NCF1","DTX3L","PMAIP1","ANK2","NUCB1","GSTK1","S100A10","COLQ","EXOC3L1","FYB1","ZDHHC19","DYNLT1","KPNA5","PYHIN1","TICAM2","PARP3","TMEM150A","PARP9","PTPRU","TNFAIP3","EDEM1","STAC3","LILRB4","FGF10","TXN","TNF","ZDHHC18","RAB24","ITGAL","ZDHHC11B","ATG3","KCNE1","STAT3","ITGB7","PAK1","SRC","TGFB1","TBC1D2B","SNX16","AKAP12","TXNIP","RRAGC","PTPN1","RHOQ","ACTN2","MAP2","PLEKHF1","GPM6B","PTGS2","RIPOR2","AMN","GAS6","PARL","CNTLN","AP1AR","SNX8","RRAGD","ANKRD13A","HERPUD1","BBC3","RILPL1","NAPA","SMAD3","RAB38","STX3","RAB39A","GAS8","ZFP36","STX17","STOM","PRR5L","FCER1G","NCOA4","TRIM46","SHISA7","FLOT1","ARC","RAPSN","ZDHHC23","GCC2","NPC1","XPO6","RUFY3"]} {"pathway":"GO_AXONEME_ASSEMBLY","pval":0.48342,"padj":0.91689,"ES":0.70286,"NES":1.00763,"nMoreExtreme":32091,"size":34,"leadingEdge":["DNAAF1","LRRC61","CFAP74","GAS8"]} {"pathway":"GO_CELL_MATURATION","pval":0.46489,"padj":0.90571,"ES":0.60068,"NES":1.00727,"nMoreExtreme":37652,"size":121,"leadingEdge":["LRRK2","IL15","GLDN","SPTBN4","SCARF1","C3","NRCAM","RND1","B4GALT5","SOX8","FARP2","ASCL1","NR4A2","CCL19","CCR6","CDKN1A","CDKN1C","CX3CL1","GATA3","SPINK1"]} {"pathway":"GO_PROTEIN_LIPID_COMPLEX_SUBUNIT_ORGANIZATION","pval":0.48948,"padj":0.91689,"ES":0.71343,"NES":1.00708,"nMoreExtreme":32043,"size":31,"leadingEdge":["AGT","SOAT1","LIPG","ABCA7"]} {"pathway":"GO_LIPID_MODIFICATION","pval":0.46879,"padj":0.90755,"ES":0.57791,"NES":1.00652,"nMoreExtreme":40921,"size":201,"leadingEdge":["SOCS1","AGT","CYP1A1","SOAT1","CISH","DGAT2","NR4A3","TMEM150A","DECR1","DGKG","SOCS3","PLPP1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_GRANULOCYTE_MACROPHAGE_COLONY_STIMULATING_FACTOR_PRODUCTION","pval":0.66141,"padj":0.94905,"ES":0.7878,"NES":1.00626,"nMoreExtreme":36961,"size":9,"leadingEdge":["CD80","RASGRP1","DDX58"]} {"pathway":"GO_RESPONSE_TO_INTERLEUKIN_6","pval":0.49253,"padj":0.91907,"ES":0.71621,"NES":1.00593,"nMoreExtreme":32107,"size":30,"leadingEdge":["STAT1","JAK2","ICAM1","SBNO2","IL6","CHI3L1","SOCS3","STAT3","PTPN2"]} {"pathway":"GO_REGULATION_OF_RESPIRATORY_GASEOUS_EXCHANGE_BY_NEUROLOGICAL_SYSTEM_PROCESS","pval":0.6637,"padj":0.94905,"ES":0.76899,"NES":1.0059,"nMoreExtreme":36075,"size":7,"leadingEdge":["GLS","TSHZ3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_FIBROBLAST_PROLIFERATION","pval":0.5087,"padj":0.9232,"ES":0.73702,"NES":1.00576,"nMoreExtreme":32405,"size":25,"leadingEdge":["PARP10","LTA","NUPR1","B4GALT7"]} {"pathway":"GO_LIPID_BIOSYNTHETIC_PROCESS","pval":0.48172,"padj":0.91676,"ES":0.55425,"NES":1.00516,"nMoreExtreme":46695,"size":534,"leadingEdge":["CD74","P2RX7","GK","CEACAM1","PLAAT3","ACSL1","CYP1A1","HSD3B7","OSBPL6","C3","HSD11B1","EDN1","DHRS9","PCYT1A","DGAT2","CDS1","PLSCR1","B4GALT5","TNF","CBR1","LPCAT2","CH25H","PLA2G4A","SMPD3","CYP27B1","ST3GAL5","NR1H3","FPR2","ELOVL7","AGPAT3","ACSS1","PTGS2","ACSM5","PLPP1","CES1","MFSD2A","SLC44A2","ERLIN1","PDGFB","RAB38","SIK1","PIGY","KDSR","AGAP2","INSIG2","ALDH1A2","LPGAT1","PROX1","MTMR8"]} {"pathway":"GO_ASPARTATE_TRANSMEMBRANE_TRANSPORT","pval":0.66512,"padj":0.94905,"ES":0.77856,"NES":1.00489,"nMoreExtreme":36648,"size":8,"leadingEdge":["SLC25A22","SLC25A13"]} {"pathway":"GO_MULTICELLULAR_ORGANISM_AGING","pval":0.51364,"padj":0.92459,"ES":0.74081,"NES":1.00473,"nMoreExtreme":32529,"size":24,"leadingEdge":["LRRK2","EDN1","COMP","CGAS","ERCC1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_BLOOD_VESSEL_DIAMETER","pval":0.47695,"padj":0.9125,"ES":0.66266,"NES":1.00404,"nMoreExtreme":33466,"size":49,"leadingEdge":["CD38","AGT","ICAM1","EDN1","COMP","SLC8A1","PTAFR","PTGS2","EDNRA"]} {"pathway":"GO_RESPONSE_TO_HORMONE","pval":0.48862,"padj":0.91689,"ES":0.55049,"NES":1.00397,"nMoreExtreme":48201,"size":727,"leadingEdge":["SOCS1","CD38","CEACAM1","RXFP1","TNFSF10","ACOD1","EGR2","SSTR2","PADI2","STAT1","JAK2","AGT","ACSL1","XRN1","ICAM1","PAQR8","BCL2L11","CTSS","JAK3","EDN1","FAM107A","CISH","IL1RN","PTGER4","LYN","EPHX1","NR4A3","CTSL","PTPRU","ANXA3","IL6","FGF10","TNF","PTGER2","STAT5A","HPN","VGF","TRIM72","HNF4G","NCOA1","CXCL12","PTAFR","NR1H3","NR4A2","SOCS3","SH2B2","STAT3","PTPN2","PAK1","GCLC","RUNX1","SRC","TGFB1","CCL19","CDKN1A","UCP2","TXNIP","ATP6V1A","PTPN1","RHOQ","SORT1","ACTN2","CREBRF","PTGS2","PLPP1","GPR150","ASNS","CFLAR","RGS9","AGTRAP","NKX3-1","NFE2L2","PPARGC1B"]} {"pathway":"GO_ZYMOGEN_ACTIVATION","pval":0.4868,"padj":0.91689,"ES":0.69372,"NES":1.00365,"nMoreExtreme":32609,"size":36,"leadingEdge":["RIPK2","C1RL","C1R","CTSZ","HPN","PLGRKT","KLK1","BAK1"]} {"pathway":"GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE","pval":0.48625,"padj":0.91689,"ES":0.55411,"NES":1.00353,"nMoreExtreme":46956,"size":502,"leadingEdge":["LRRK2","AGT","BCL2L11","PML","ZC3H12A","ACOT4","PMAIP1","GSTK1","KPNA5","TNFAIP3","STAT3","TGFB1","SNX16","TXNIP","PTGS2","PARL","BBC3","SMAD3","NCOA4","ARC","GCC2"]} {"pathway":"GO_VESICLE_DOCKING","pval":0.47567,"padj":0.91085,"ES":0.6435,"NES":1.00352,"nMoreExtreme":34569,"size":61,"leadingEdge":["PLEK","STX11","RALB","STX3","STX17"]} {"pathway":"GO_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION","pval":0.47293,"padj":0.90882,"ES":0.60876,"NES":1.00327,"nMoreExtreme":37207,"size":100,"leadingEdge":["CEACAM1","STAT1","MAFF","CTSL","PRKX","TNF","ASCL1","CYP27B1","RUNX1","CDKN1C","FOXC1","GATA3","ZFP36"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION","pval":0.47546,"padj":0.91084,"ES":0.64093,"NES":1.00319,"nMoreExtreme":34726,"size":63,"leadingEdge":["CEACAM1","LILRB3","LYN","TLR3","LILRB4","LILRB1","PTPN2","C1QC","NFKBIA","CCL3","ZFP36","TLR4","GPR171"]} {"pathway":"GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS_VIA_GERMLINE_RECOMBINATION_WITHIN_A_SINGLE_LOCUS","pval":0.47832,"padj":0.91418,"ES":0.65158,"NES":1.00251,"nMoreExtreme":34147,"size":55,"leadingEdge":["CD40","TBX21","POLB","BCL6","PARP3","PTPRC","NBN","TGFB1","CCR6","LIG4"]} {"pathway":"GO_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS","pval":0.47584,"padj":0.91085,"ES":0.63354,"NES":1.00247,"nMoreExtreme":35219,"size":69,"leadingEdge":["JAK2","AGT","ICAM1","KLF4","ZC3H12A","P2RX4","EDN1","CTNS","TNF","CD47","STAT3","ADGRB1","PTGS2","CFLAR","MIR212","SMAD3","TLR4","ASS1","TICAM1","HDAC4"]} {"pathway":"GO_REGULATION_OF_CELL_PROLIFERATION_INVOLVED_IN_KIDNEY_DEVELOPMENT","pval":0.63038,"padj":0.94878,"ES":0.79153,"NES":1.00233,"nMoreExtreme":36361,"size":12,"leadingEdge":["CFLAR","GATA3","LIN28A","PDGFB"]} {"pathway":"GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND","pval":0.4844,"padj":0.91689,"ES":0.67922,"NES":1.00221,"nMoreExtreme":33105,"size":41,"leadingEdge":["IL7","FGF10","TNF","IFI6","MCL1","CX3CL1","IL1A","FYN"]} {"pathway":"GO_RESPONSE_TO_SALT","pval":0.60354,"padj":0.94684,"ES":0.78729,"NES":1.0019,"nMoreExtreme":35524,"size":14,"leadingEdge":["ZC3H12A","EDN1","TGFB1","HSPA5"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_OXYGEN_RADICAL","pval":0.54099,"padj":0.92919,"ES":0.75873,"NES":1.00168,"nMoreExtreme":33440,"size":20,"leadingEdge":["GCH1","SOD2","TNF","PRDX1","NFE2L2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TOR_SIGNALING","pval":0.49348,"padj":0.91907,"ES":0.70197,"NES":1.00157,"nMoreExtreme":32620,"size":33,"leadingEdge":["RRAGC","GAS6","RRAGD","LIN28A","CLEC16A"]} {"pathway":"GO_METANEPHRIC_NEPHRON_DEVELOPMENT","pval":0.49802,"padj":0.91907,"ES":0.70934,"NES":1.00131,"nMoreExtreme":32602,"size":31,"leadingEdge":["STAT1","SOX8","PDGFRA","PDGFB","PKD1"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_INORGANIC_SUBSTANCE","pval":0.47922,"padj":0.91524,"ES":0.58005,"NES":1.0013,"nMoreExtreme":41053,"size":176,"leadingEdge":["LRRK2","ATP13A2","CAMK2D","CYP1A1","B2M","P2RX4","EDN1","NCF1","MT2A","MT1M","MT1E","SMPD3","GUCA1A","SYT5","MT1H","HVCN1","LIG4","PTGS2","GUCY1B1","CFLAR","MT1G","NFE2L2","SYT17"]} {"pathway":"GO_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC","pval":0.47932,"padj":0.91524,"ES":0.64086,"NES":1.00113,"nMoreExtreme":34909,"size":62,"leadingEdge":["LRRK2","GRM8","GLUL","TNF","CCL2","KMO","PTGS2","NAPA","MAPK8IP2","CLSTN3","ADORA2A"]} {"pathway":"GO_RESPONSE_TO_AXON_INJURY","pval":0.48033,"padj":0.91608,"ES":0.64326,"NES":1.00111,"nMoreExtreme":34816,"size":60,"leadingEdge":["KREMEN1","JAK2","KLF4","SCARF1","P2RX4","LYN","P2RY12","RGMA"]} {"pathway":"GO_AXON_REGENERATION","pval":0.48627,"padj":0.91689,"ES":0.67826,"NES":1.0008,"nMoreExtreme":33233,"size":41,"leadingEdge":["KREMEN1","JAK2","KLF4","SCARF1","RGMA"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MAP_KINASE_ACTIVITY","pval":0.48517,"padj":0.91689,"ES":0.57053,"NES":1.00061,"nMoreExtreme":43047,"size":227,"leadingEdge":["CD40","CD74","P2RX7","LRRK2","NOD2","HGF","JAK2","RIPK2","EDN1","NRK","GADD45B","FGF10","GADD45G","TNF","FLT1","RASGRP1","FGD2","PTPRC","PAK1","SRC","TGFB1","ROBO1","CCL19","DUSP5","PTPN1","LPAR1"]} {"pathway":"GO_LACRIMAL_GLAND_DEVELOPMENT","pval":0.6171,"padj":0.94878,"ES":0.72727,"NES":1.00042,"nMoreExtreme":32652,"size":5,"leadingEdge":["FGF10","FOXC1","FGFR2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_BLOOD_CIRCULATION","pval":0.48851,"padj":0.91689,"ES":0.68022,"NES":1.00036,"nMoreExtreme":33298,"size":40,"leadingEdge":["GCH1","CD38","ICAM1","EDN1","RNF207","PTGER2","PTAFR","PTGS2"]} {"pathway":"GO_COMPLEMENT_ACTIVATION_ALTERNATIVE_PATHWAY","pval":0.66761,"padj":0.94905,"ES":0.77446,"NES":0.9996,"nMoreExtreme":36785,"size":8,"leadingEdge":["CFH","CFB","C3"]} {"pathway":"GO_REGULATION_OF_PROTEIN_BINDING","pval":0.48521,"padj":0.91689,"ES":0.57502,"NES":0.99945,"nMoreExtreme":42159,"size":195,"leadingEdge":["LRRK2","RIPK2","B2M","CYLD","RAPGEF2","IFIT2","CARD16","XIRP1","RALB","DTX3L","DTNBP1","CTSZ","TEX14","SRC","MAP2","RIPOR2","MITD1","NKX3-1","HERPUD1","PDGFB","GAS8","SPTA1","BAK1","FLOT1"]} {"pathway":"GO_MACROPHAGE_DIFFERENTIATION","pval":0.49461,"padj":0.91907,"ES":0.69365,"NES":0.99907,"nMoreExtreme":32966,"size":35,"leadingEdge":["IL31RA","CSF1","PTPN2","TGFB1","C1QC"]} {"pathway":"GO_BILE_ACID_SECRETION","pval":0.61745,"padj":0.94878,"ES":0.72629,"NES":0.99906,"nMoreExtreme":32671,"size":5,"leadingEdge":["SLC51A","ABCB4"]} {"pathway":"GO_PROTEIN_AUTOUBIQUITINATION","pval":0.48369,"padj":0.91689,"ES":0.64194,"NES":0.99906,"nMoreExtreme":35060,"size":60,"leadingEdge":["LRRK2","TRIM17","RNF19B","DTX3L","UBE2A","TRIM71","TRIM21","SH3RF1"]} {"pathway":"GO_COMPLEMENT_ACTIVATION_LECTIN_PATHWAY","pval":0.61745,"padj":0.94878,"ES":0.72622,"NES":0.99897,"nMoreExtreme":32671,"size":5,"leadingEdge":["SERPING1","A2M"]} {"pathway":"GO_URATE_TRANSPORT","pval":0.50354,"padj":0.91988,"ES":0.74934,"NES":0.99876,"nMoreExtreme":25195,"size":1,"leadingEdge":["SLC2A9"]} {"pathway":"GO_NETRIN_ACTIVATED_SIGNALING_PATHWAY","pval":0.66574,"padj":0.94905,"ES":0.7816,"NES":0.99835,"nMoreExtreme":37203,"size":9,"leadingEdge":["UNC5C","NTN1","UNC5CL"]} {"pathway":"GO_REGULATION_OF_HEART_RATE_BY_CARDIAC_CONDUCTION","pval":0.49726,"padj":0.91907,"ES":0.69636,"NES":0.99831,"nMoreExtreme":33010,"size":34,"leadingEdge":["KCNJ2","CAMK2D","ANK2","KCNE5","KCNE1","KCNE1B"]} {"pathway":"GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_MIGRATION","pval":0.50373,"padj":0.91988,"ES":0.71077,"NES":0.99828,"nMoreExtreme":32837,"size":30,"leadingEdge":["CXCL10","CCL7","CCL5","TNFRSF14","CXCL12","CCL4","CCL3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ORGANELLE_ASSEMBLY","pval":0.49539,"padj":0.91907,"ES":0.68965,"NES":0.99776,"nMoreExtreme":33185,"size":36,"leadingEdge":["LRRK2","PHF23"]} {"pathway":"GO_TRANSLATIONAL_INITIATION","pval":0.48884,"padj":0.91689,"ES":0.57638,"NES":0.9977,"nMoreExtreme":42116,"size":183,"leadingEdge":["BANK1","CCL5","TNF","EIF2AK2"]} {"pathway":"GO_REGULATION_OF_LIPOPROTEIN_PARTICLE_CLEARANCE","pval":0.62142,"padj":0.94878,"ES":0.7872,"NES":0.99752,"nMoreExtreme":36191,"size":13,"leadingEdge":["LIPG","MYLIP"]} {"pathway":"GO_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS","pval":0.52395,"padj":0.92669,"ES":0.54434,"NES":0.99742,"nMoreExtreme":52359,"size":1514,"leadingEdge":["IL31RA","CD40","GBP1","CD74","P2RX7","SOCS1","LRRK2","IL15","CXCL10","NOD2","CEACAM1","CCL13","HGF","BANK1","ATF3","LMTK2","NMI","JAK2","AGT","RIPK2","TLR8","STAT2","CCL7","FAS","ACSL1","CAMK2D","SPTBN4","ICAM1","KLF4","MUC1","CCL15","FLT3LG","TNFSF18","CD80","PML","FAM20A","CCL8","C3","SCIMP","ZC3H12A","PARP10","CYLD","RAPGEF2","STAP1","ENPP2","RALB","BTN2A2","EDN1","VEGFC","SLAMF1","NCF1","DTX3L","NRK","MIR503","FAM107A","MVP","IL1RN","GADD45B","STAP2","DYSF","GLIPR2","BCL6","PPM1E","CCL18","CCL5","LYN","IL12A","DTNBP1","TRABD2A","PARP14","TLR7","CSF1","VRK2","TNFRSF14","TANK","PARP9","IL7","AMER1","GAREM1","TNFAIP3","BIRC3","IL6","TLR3","FGF10","TXN","GADD45G","SEMA7A","NOTCH2","TNF","FLT1","SPOPL","DUSP10","RASGRP1","SMPD3","CCL1","FGD2","LCP2","PTPRC","CHI3L1","CCL4","AUTS2","FPR2","SOCS3","CCL2","STAT3","NBN","PTPN2","PAK1","GCLC","SRC","TGFB1","ROBO1","CCL19","CDKN1A","UVRAG","PRDX1","PDGFRA","TRIM21","ADAR","DUSP5","CDKN1C","PTPN1","ADGRB1","ISG15","PKHD1","CCNL1","SH3RF1","LPAR1","OTUD4","PTGS2","ELFN1","GAS6","CCL3","CX3CL1","CFLAR","TCIM","GATA3","BIRC7","NKX3-1","SRCIN1","MIR212","SEMA4D","CCNA1","SPINK1","HERPUD1","PLCB1"]} {"pathway":"GO_ENSHEATHMENT_OF_NEURONS","pval":0.48412,"padj":0.91689,"ES":0.60351,"NES":0.99733,"nMoreExtreme":38264,"size":103,"leadingEdge":["HGF","EGR2","KCNJ10","TYMP","ANK2","B4GALT5","TGFB1","LPAR1"]} {"pathway":"GO_BRANCH_ELONGATION_OF_AN_EPITHELIUM","pval":0.56331,"padj":0.93517,"ES":0.76575,"NES":0.99728,"nMoreExtreme":34272,"size":18,"leadingEdge":["FGF10","TGFB1","HNF1B","SIX1"]} {"pathway":"GO_PROTEIN_CONTAINING_COMPLEX_DISASSEMBLY","pval":0.49795,"padj":0.91907,"ES":0.56031,"NES":0.99725,"nMoreExtreme":45849,"size":303,"leadingEdge":["CALCOCO2","PLEK","SPTBN4","SCIN","AMER1","TNF","STMN3","UVRAG","STMND1","ACTN2","NAPA","SPTA1","STX17"]} {"pathway":"GO_REGULATION_OF_BINDING","pval":0.49766,"padj":0.91907,"ES":0.55799,"NES":0.997,"nMoreExtreme":46299,"size":330,"leadingEdge":["LRRK2","JAK2","RIPK2","KLF4","SRI","B2M","CYLD","RAPGEF2","IFIT2","CARD16","XIRP1","RALB","DTX3L","S100A10","PYHIN1","DTNBP1","PARP9","IRF4","CTSZ","TXN","TEX14","SRC","TGFB1","NFKBIA","MAP2","RIPOR2","FOXC1","GATA3","MITD1","NKX3-1","HERPUD1","CLIC2","PDGFB","SMAD3","GAS8","SPTA1","BAK1","NGF","C9orf72","FLOT1","GTF2B"]} {"pathway":"GO_MONOCARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS","pval":0.488,"padj":0.91689,"ES":0.58741,"NES":0.99695,"nMoreExtreme":40440,"size":140,"leadingEdge":["IDO1","CD74","CEACAM1","CYP1A1","HSD3B7","OSBPL6","EDN1","CBR1","CH25H","NR1H3","ELOVL7","KMO","ACSS1","PTGS2","ACSM5","ERLIN1"]} {"pathway":"GO_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS","pval":0.50198,"padj":0.91978,"ES":0.55623,"NES":0.99691,"nMoreExtreme":47120,"size":356,"leadingEdge":["GSAP","BANK1","XRN1","SAMD4A","ZC3H12A","PIWIL4","MIR503","CCL5","IL6","TNF","SMPD3","MOV10","PTAFR","STAT3","TRIM71","NFE2L2","LIN28A","MIR212","ZFP36"]} {"pathway":"GO_ODONTOGENESIS","pval":0.48557,"padj":0.91689,"ES":0.61093,"NES":0.99652,"nMoreExtreme":37540,"size":91,"leadingEdge":["SNX10","BCL2L11","FAM20A","EDN1","CSF1","FGF10","SMPD3","TGFB1","PDGFRA","FOXC1"]} {"pathway":"GO_AMEBOIDAL_TYPE_CELL_MIGRATION","pval":0.50008,"padj":0.91966,"ES":0.55758,"NES":0.99642,"nMoreExtreme":46552,"size":331,"leadingEdge":["CD40","CEACAM1","AMOT","AGT","KLF4","PML","ZC3H12A","P2RX4","ENPP2","EDN1","VEGFC","MIR503","GLIPR2","GLUL","PRKX","ANXA3","FGF10","EGR3","SEMA7A","SOX8","STAT5A","SLC8A1","DUSP10","P2RY12","ITGB7","PAK1","SRC","TGFB1","SEMA4A","ROBO1","CCR6","ADGRB1","PTGS2","HAS2","GATA3","NFE2L2","MIR212","SEMA4D","PDGFB","SLIT2","PRR5L"]} {"pathway":"GO_PEPTIDYL_SERINE_MODIFICATION","pval":0.49816,"padj":0.91907,"ES":0.56341,"NES":0.99637,"nMoreExtreme":45143,"size":265,"leadingEdge":["LRRK2","HGF","LMTK2","RIPK2","CAMK2D","SPTBN4","VRK2","PRKX","IL6","TXN","AURKC","TNF","PAK1","SRC","TGFB1","IKBKE","PTGS2","GAS6","MIR212","PDGFB","BAK1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION","pval":0.64816,"padj":0.94878,"ES":0.78683,"NES":0.99637,"nMoreExtreme":37009,"size":11,"leadingEdge":["CEACAM1","CCM2L"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_17_PRODUCTION","pval":0.6482,"padj":0.94878,"ES":0.78673,"NES":0.99624,"nMoreExtreme":37011,"size":11,"leadingEdge":["IL12A","TGFB1","TLR4"]} {"pathway":"GO_TAXIS","pval":0.51227,"padj":0.92419,"ES":0.54987,"NES":0.99623,"nMoreExtreme":49524,"size":510,"leadingEdge":["CD74","CXCL11","PDE4B","CXCL10","CCL13","AMOT","HGF","CXCL9","EGR2","PADI2","SUCNR1","CCL7","TYMP","VCAM1","SPTBN4","HSD3B7","CCL15","CCL8","CCRL2","P2RX4","STAP1","ENPP2","EDN1","VEGFC","IL1RN","DYSF","SLAMF8","CCL18","CCL5","LYN","IL12A","CSF1","NR4A3","NRCAM","CXCL16","IL6","FGF10","EGR3","SEMA7A","FLT1","CH25H","GPR18","CAMK1D","CCR5","CCL1","UNC5C","NTN1","CXCL12","PTAFR","CCL4","FPR2","ACKR4","F3","CCL2","P2RY12","PTPN2","SRC","TGFB1","SEMA4A","ROBO1","CCL19","CCR6","CXCL8","PDGFRA","ISL2","LPAR1","PLGRKT","RIPOR2","GAS6","CCL3","CX3CL1","EPHA10","GATA3","SEMA4D","ELMO2","DAPK2","PDGFB","SMAD3","STX3","SPTA1","SLIT2","FCER1G","BOC"]} {"pathway":"GO_PYROPTOSIS","pval":0.6671,"padj":0.94905,"ES":0.77991,"NES":0.99618,"nMoreExtreme":37279,"size":9,"leadingEdge":["AIM2","GSDMD","GSDMB"]} {"pathway":"GO_REGULATION_OF_CATECHOLAMINE_METABOLIC_PROCESS","pval":0.63566,"padj":0.94878,"ES":0.78639,"NES":0.99583,"nMoreExtreme":36666,"size":12,"leadingEdge":["NR4A2","DRD4"]} {"pathway":"GO_EOSINOPHIL_MIGRATION","pval":0.54854,"padj":0.93125,"ES":0.75412,"NES":0.99559,"nMoreExtreme":33907,"size":20,"leadingEdge":["CCL13","CCL7","CCL15","CCL8","PTGER4","CCL5","CCL1","CCL4","CCL2","CCL3","CX3CL1","DAPK2"]} {"pathway":"GO_PANCREAS_DEVELOPMENT","pval":0.49099,"padj":0.9183,"ES":0.6469,"NES":0.99531,"nMoreExtreme":35051,"size":55,"leadingEdge":["ONECUT2","SIDT2","DNAAF1","IL6","FGF10","BAK1","ALDH1A2","MET","PROX1","HNF1B","NR5A2"]} {"pathway":"GO_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS","pval":0.48925,"padj":0.91689,"ES":0.63192,"NES":0.99505,"nMoreExtreme":35995,"size":66,"leadingEdge":["PLEK","TNF","CYP27B1","PTAFR","ERLIN1","CD244","NFYA"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_ETHANOL","pval":0.63641,"padj":0.94878,"ES":0.78573,"NES":0.99499,"nMoreExtreme":36709,"size":12,"leadingEdge":["CCL7","KCNMB1","SPI1"]} {"pathway":"GO_REGULATION_OF_PRESYNAPSE_ORGANIZATION","pval":0.54945,"padj":0.93134,"ES":0.75364,"NES":0.99496,"nMoreExtreme":33963,"size":20,"leadingEdge":["MDGA1","NTNG2","CLSTN3"]} {"pathway":"GO_VIRION_ASSEMBLY","pval":0.49883,"padj":0.91907,"ES":0.68462,"NES":0.99468,"nMoreExtreme":33555,"size":37,"leadingEdge":["USP6NL","CHMP4C","RAB43","VTA1"]} {"pathway":"GO_PHENOL_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS","pval":0.5165,"padj":0.92482,"ES":0.71982,"NES":0.99429,"nMoreExtreme":33210,"size":27,"leadingEdge":["GCH1","RAPGEF2","CTNS","NR4A2","GATA3"]} {"pathway":"GO_BRADYKININ_CATABOLIC_PROCESS","pval":0.56481,"padj":0.93517,"ES":0.69796,"NES":0.99392,"nMoreExtreme":29395,"size":4,"leadingEdge":["CTSH","XPNPEP1","ECE1","IDE"]} {"pathway":"GO_SIGNAL_TRANSDUCTION_IN_ABSENCE_OF_LIGAND","pval":0.49239,"padj":0.91907,"ES":0.63614,"NES":0.99375,"nMoreExtreme":35861,"size":62,"leadingEdge":["BCL2A1","BCL2L11","IL7","FGF10","TNF","IFI6","MCL1","CX3CL1","BAK1","IL1A"]} {"pathway":"GO_MORPHOGENESIS_OF_AN_EPITHELIAL_BUD","pval":0.63738,"padj":0.94878,"ES":0.78474,"NES":0.99373,"nMoreExtreme":36765,"size":12,"leadingEdge":["FGF10","FGFR2"]} {"pathway":"GO_REGULATION_OF_NOTCH_SIGNALING_PATHWAY","pval":0.49015,"padj":0.9179,"ES":0.61331,"NES":0.99365,"nMoreExtreme":37530,"size":85,"leadingEdge":["NOD2","BCL6","CHAC1","FGF10","ASCL1","STAT3","ROBO1","NFKBIA","TCIM","MIR212","SLC35C2","WNT1","MAML2","GDPD5"]} {"pathway":"GO_EXTRACELLULAR_MATRIX_CONSTITUENT_SECRETION","pval":0.66109,"padj":0.94905,"ES":0.78252,"NES":0.99343,"nMoreExtreme":37315,"size":10,"leadingEdge":["AGT","TNFRSF1B"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY","pval":0.50563,"padj":0.92004,"ES":0.56121,"NES":0.99343,"nMoreExtreme":45928,"size":270,"leadingEdge":["GBP1","VAMP5","OPTN","SPTBN4","RAPGEF2","ANK2","S100A10","FYB1","TMEM150A","STAC3","TNF","TGFB1","RHOQ","ACTN2","PLEKHF1","AMN","GAS6","RILPL1","STX3","FCER1G","FLOT1","RAPSN","ZDHHC23"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING","pval":0.63773,"padj":0.94878,"ES":0.78448,"NES":0.99341,"nMoreExtreme":36785,"size":12,"leadingEdge":["GBP1","AP1AR"]} {"pathway":"GO_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY","pval":0.52538,"padj":0.92669,"ES":0.54661,"NES":0.99336,"nMoreExtreme":51258,"size":590,"leadingEdge":["P2RY14","LRRK2","CXCL11","PDE4B","CXCL10","ADGRE5","CCL13","PLEK","RXFP1","CYSLTR2","CXCL9","SSTR2","HCAR2","JAK2","SUCNR1","AGT","HCAR3","ECEL1","CCL7","CCL15","TGM2","GRM8","NXPH2","CCL8","C3","CCRL2","RAPGEF2","NPR1","GPR31","EDN1","IGF2R","CISH","ADGRG5","PTGER4","DYNLT1","CCL18","CCL5","DTNBP1","ARHGEF3","CXCL16","PTGER2","P2RY13","ADM2","DGKG","GPR18","F2RL2","RGS7BP","CCR5","CCL1","FGD2","CXCL12","PTAFR","CCL4","FPR2","GPR50","ACKR4","CCL2","GUCA1A","P2RY12","SRC","CCL19","CCR6","GPR85","CXCL8","AKAP12","GP1BA","OGFR","P2RY2","SORT1","ACTN2","GABRR2","ADGRB1","LPAR1","PLPP1","GPR150","CCL3","RGS1","CX3CL1","ACPP","RGS9","GNG10","AGTRAP"]} {"pathway":"GO_REGULATION_OF_CELL_PROJECTION_ORGANIZATION","pval":0.52588,"padj":0.92669,"ES":0.54687,"NES":0.99318,"nMoreExtreme":51197,"size":571,"leadingEdge":["P2RX7","LRRK2","CD38","HGF","KREMEN1","AGT","ICAM1","KLF4","SCARF1","B2M","CYLD","RAPGEF2","STAP1","ENPP2","C21orf91","LYN","CDKL1","NRCAM","CTSZ","SEMA7A","CAMK1D","MOV10","NTN1","CXCL12","ATG3","AUTS2","P2RY12","PAK1","PODXL","SRC","SEMA4A","CDC42EP2","ROBO1","CCL19","RHOQ","MAP2","RGMA","LPAR1","RIPOR2","CX3CL1","CFLAR","GATA3","NFE2L2","SRCIN1","SEMA4D","SYT17","DENND5A","SLIT2","TRIM46","NGF","PPP1R16B","ARC","RUFY3","COBL","MCF2","HAP1","LIMK1","PTN","LZTS1","WNT1","SEMA3F"]} {"pathway":"GO_REGULATION_OF_T_HELPER_1_TYPE_IMMUNE_RESPONSE","pval":0.52907,"padj":0.92669,"ES":0.73208,"NES":0.99289,"nMoreExtreme":33506,"size":24,"leadingEdge":["IL12RB1","RIPK2","IL27","CD80","JAK3","CCL19","IL33","HLX"]} {"pathway":"GO_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION","pval":0.5022,"padj":0.91978,"ES":0.68317,"NES":0.99258,"nMoreExtreme":33782,"size":37,"leadingEdge":["RIPK2","CHI3L1","TGFB1","SIRT2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION","pval":0.61307,"padj":0.94703,"ES":0.77994,"NES":0.99255,"nMoreExtreme":36085,"size":14,"leadingEdge":["CYP27B1","FOXC1","PRKCH"]} {"pathway":"GO_METANEPHRIC_DISTAL_TUBULE_DEVELOPMENT","pval":0.50182,"padj":0.91978,"ES":0.67365,"NES":0.99248,"nMoreExtreme":25653,"size":3,"leadingEdge":["PKD1","PKD2","PAX8"]} {"pathway":"GO_ENDOMEMBRANE_SYSTEM_ORGANIZATION","pval":0.51652,"padj":0.92482,"ES":0.55261,"NES":0.99229,"nMoreExtreme":48711,"size":373,"leadingEdge":["P2RX7","LRRK2","SNX10","OPTN","MYOF","ANO4","USP6NL","ANK2","DYSF","XKR6","CHMP4C","DTNBP1","TICAM2","PLSCR4","PLSCR1","FCHO1","TRIM72","PDE4DIP","XKR8","PTPRC","VCPIP1","PARP11","PLEKHF1","XKR7","DNAJC13","RAB38","SPTA1","STX17","REEP4","FLOT1","GCC2"]} {"pathway":"GO_MEMBRANE_PROTEIN_PROTEOLYSIS","pval":0.49569,"padj":0.91907,"ES":0.64637,"NES":0.99224,"nMoreExtreme":35283,"size":54,"leadingEdge":["P2RX7","TNF","PSEN2","TGFB1","SPPL2A","PARL","ERAP1","PRKCQ"]} {"pathway":"GO_BLOOD_VESSEL_REMODELING","pval":0.50805,"padj":0.92271,"ES":0.69526,"NES":0.992,"nMoreExtreme":33583,"size":33,"leadingEdge":["CEACAM1","AGT","TGM2","FGF10","TGFB1","FOXC1","BAK1"]} {"pathway":"GO_NEPHRON_MORPHOGENESIS","pval":0.49527,"padj":0.91907,"ES":0.62978,"NES":0.99169,"nMoreExtreme":36438,"size":66,"leadingEdge":["STAT1","AGT","SOX8","TGFB1","GATA3","HOXD11","WNT1","HNF1B","SIX1"]} {"pathway":"GO_REGULATION_OF_SKELETAL_MUSCLE_ADAPTATION","pval":0.63929,"padj":0.94878,"ES":0.7831,"NES":0.99165,"nMoreExtreme":36875,"size":12,"leadingEdge":["MYH7","GTF2IRD1"]} {"pathway":"GO_REGULATION_OF_CELL_MORPHOGENESIS","pval":0.52232,"padj":0.9256,"ES":0.54993,"NES":0.99125,"nMoreExtreme":49741,"size":419,"leadingEdge":["GBP1","LRRK2","CCL13","ITGA7","CCL7","ICAM1","S100A13","RAPGEF2","ENPP2","RHOBTB3","S100A10","FMNL2","NRCAM","RND1","PLEKHO1","SEMA7A","HPN","MOV10","FGD2","NTN1","CXCL12","RHOH","CCL2","PAK1","SRC","SEMA4A","CDC42EP2","ROBO1","RHOQ","MAP2","LPAR1","HAS2","CCL3","AP1AR","SRCIN1","SEMA4D","FGD6","SYT17","CDC42SE2","SPTA1","SLIT2","TRIM46","NGF","ARC","RUFY3","MCF2","LIMK1","PTN","COCH","LZTS1","SEMA3F"]} {"pathway":"GO_ACUTE_INFLAMMATORY_RESPONSE","pval":0.49608,"padj":0.91907,"ES":0.61744,"NES":0.99118,"nMoreExtreme":37471,"size":78,"leadingEdge":["IL31RA","APOL2","HLA-E","VCAM1","ICAM1","C3","PLSCR1","IL6","TNF","F3","STAT3","PTGS2","GATA3","IL1A","NUPR1","FCER1G","SAA2","ASS1"]} {"pathway":"GO_CHROMATIN_MEDIATED_MAINTENANCE_OF_TRANSCRIPTION","pval":0.66985,"padj":0.94905,"ES":0.77598,"NES":0.99116,"nMoreExtreme":37433,"size":9,"leadingEdge":["PADI2","ARID1B"]} {"pathway":"GO_RESPONSE_TO_NITROGEN_COMPOUND","pval":0.54006,"padj":0.92877,"ES":0.54318,"NES":0.99114,"nMoreExtreme":53352,"size":752,"leadingEdge":["CD40","P2RX7","SOCS1","LRRK2","PDE4B","NOD2","CEACAM1","SELL","TNFSF10","EGR2","STAT1","JAK2","AGT","RIPK2","XRN1","VCAM1","ICAM1","KLF4","JAK3","P2RX4","RAPGEF2","CASP4","CASP7","RALB","EDN1","IFIH1","PMAIP1","CISH","LYN","NR4A3","KYNU","TNFAIP3","MYD88","IL6","TLR3","TNF","STAT5A","SLC8A1","VGF","TRIM72","SMPD3","ASCL1","CXCL12","PTAFR","DDX58","NR4A2","KCNE1","FPR2","SOCS3","SH2B2","STAT3","P2RY12","PTPN2","PAK1","GCLC","SRC","TGFB1","CCL19","CGAS","CDKN1A","UCP2","ATP6V1A","PDGFRA","NAMPT","RRAGC","PTPN1","P2RY2","RHOQ","SORT1","NFKBIA","ACTN2","PTGS2","ASNS","IRF5","GUCY1B1","CFLAR","RGS9","RRAGD","AGTRAP","NFE2L2","PPARGC1B"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_PEPTIDE","pval":0.5173,"padj":0.9251,"ES":0.55659,"NES":0.99035,"nMoreExtreme":47590,"size":301,"leadingEdge":["SOCS1","NOD2","CEACAM1","STAT1","JAK2","AGT","RIPK2","VCAM1","ICAM1","KLF4","JAK3","CASP4","EDN1","CISH","LYN","NR4A3","STAT5A","TRIM72","SMPD3","NR4A2","FPR2","SOCS3","SH2B2","STAT3","PTPN2","PAK1","GCLC","SRC","TGFB1","UCP2","ATP6V1A","NAMPT","PTPN1","RHOQ","ACTN2","CFLAR","AGTRAP","NFE2L2"]} {"pathway":"GO_CELLULAR_SENESCENCE","pval":0.49829,"padj":0.91907,"ES":0.63776,"NES":0.99027,"nMoreExtreme":35994,"size":59,"leadingEdge":["PML","HLA-G","BCL6","CGAS","CDKN1A","NAMPT","ZNF277","MAGEA2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_HORMONE_SECRETION","pval":0.49783,"padj":0.91907,"ES":0.61103,"NES":0.98996,"nMoreExtreme":38118,"size":85,"leadingEdge":["CD38","HCAR2","JAK2","SRI","EDN1","GLUL","NKX3-1","NADK","ILDR1"]} {"pathway":"GO_IRON_ION_TRANSMEMBRANE_TRANSPORT","pval":0.60453,"padj":0.94684,"ES":0.77471,"NES":0.9898,"nMoreExtreme":35922,"size":15,"leadingEdge":["STEAP4","SLC25A28","HFE"]} {"pathway":"GO_AMMONIUM_TRANSPORT","pval":0.49991,"padj":0.91966,"ES":0.63228,"NES":0.98966,"nMoreExtreme":36512,"size":63,"leadingEdge":["EDN1","SLC18A1","LYN","DTNBP1","SLC25A45","AZIN2","CXCL12","LILRB1","SYT5","SLC22A1","GPM6B","SLC44A2","SYT17","FCER1G","ADORA2A"]} {"pathway":"GO_METANEPHRIC_RENAL_VESICLE_MORPHOGENESIS","pval":0.64107,"padj":0.94878,"ES":0.78148,"NES":0.98961,"nMoreExtreme":36978,"size":12,"leadingEdge":["STAT1","SALL1"]} {"pathway":"GO_RESPONSE_TO_LIPOTEICHOIC_ACID","pval":0.67128,"padj":0.94905,"ES":0.77424,"NES":0.98895,"nMoreExtreme":37513,"size":9,"leadingEdge":["RIPK2","TLR4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS","pval":0.65434,"padj":0.94878,"ES":0.78046,"NES":0.9883,"nMoreExtreme":37362,"size":11,"leadingEdge":["IDO1","CD274","PDCD1","CCL5","PRELID1"]} {"pathway":"GO_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS","pval":0.51599,"padj":0.92482,"ES":0.56453,"NES":0.9877,"nMoreExtreme":45525,"size":217,"leadingEdge":["CHRD","AGT","MYOF","ONECUT2","VEGFC","MIR503","FGF10","HTRA4","CHST11","FLT1","TGFB1","ROBO1","CDKN1C","PTPN1","CFLAR","GATA3","SMAD3","SLIT2","SHISA2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PEPTIDE_HORMONE_SECRETION","pval":0.50293,"padj":0.91978,"ES":0.63597,"NES":0.9875,"nMoreExtreme":36329,"size":59,"leadingEdge":["CD38","JAK2","SRI","GLUL","NADK","ILDR1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_RNA_BIOSYNTHETIC_PROCESS","pval":0.57799,"padj":0.94163,"ES":0.53867,"NES":0.98666,"nMoreExtreme":57726,"size":1300,"leadingEdge":["IRF1","IL31RA","ASCL2","CD40","CD74","CIITA","CD38","TBX21","CXCL10","NOD2","HGF","NLRC5","EGR2","ATF3","PADI2","STAT1","AGT","RIPK2","ONECUT2","OVOL1","CASZ1","KLF4","MUC1","ARNTL2","FLT3LG","CD80","PML","ZC3H12A","EBF4","ATF5","IRF7","EDN1","NCF1","DTX3L","SBNO2","MAFF","BACH1","RELB","LITAF","PYHIN1","NR4A3","PARP9","TFEC","PLSCR1","IRF4","NFE2L3","IL6","TLR3","FGF10","RFX5","EGR3","TBX19","NFKB2","TNF","SOX8","CD86","HELZ2","HNF4G","NCOA1","ASCL1","DDX58","NR1H3","NR4A2","AUTS2","LILRB1","KLF6","MAFA","STAT3","MACC1","RUNX1","SRC","TGFB1","STAT4","AKIRIN2","NAMPT","CDKN1C","RHOQ","NFKBIA","ACTN2","RGMA","EGR4","CREBRF","IKZF4","HOXD8","IRF5","CX3CL1","FOXC1","GATA3","ERLIN1","PCGF5","NKX3-1","IRF2","NFE2L2","IL33","PPARGC1B"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_VIRAL_ENTRY_INTO_HOST_CELL","pval":0.60822,"padj":0.94703,"ES":0.77222,"NES":0.98662,"nMoreExtreme":36141,"size":15,"leadingEdge":["IFITM2","IFITM1","TRIM31","IFITM3","TRIM25"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELL_DIFFERENTIATION","pval":0.56147,"padj":0.93517,"ES":0.54032,"NES":0.98646,"nMoreExtreme":55563,"size":786,"leadingEdge":["CD74","SOCS1","IL12RB1","IL15","CEACAM1","HGF","CXCL9","STAT1","JAK2","AGT","RIPK2","SCARF1","IFITM1","FLT3LG","CD80","ZC3H12A","CYLD","P2RX4","RAPGEF2","SCIN","BTN2A2","EDN1","VEGFC","C21orf91","S100A10","GLIPR2","HLA-G","BCL6","LYN","CSF1","LTA","IL7","NRCAM","SOD2","CD83","IL6","LILRB4","EGR3","SEMA7A","TNF","SOX8","DUSP10","CD86","RASGRP1","CAMK1D","NCOA1","ASCL1","NTN1","CXCL12","CYP27B1","PTPRC","SOCS3","STAT3","P2RY12","PAK1","TGIF2","RUNX1","TGFB1","OCSTAMP","ROBO1","IL2RA","CCL19","ADGRB1","LIG4","ISG15","LPAR1","PTGS2","RIPOR2","ADAMTS20","HAS2","GAS6","CCL3","CX3CL1","FOXC1","CFLAR","GATA3","NFE2L2","PPARGC1B","LIN28A","SEMA4D","CD53","PLCB1","SMAD3","SYT17","ZFP36","SLIT2","BOC","HLX","NGF"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING","pval":0.58547,"padj":0.94167,"ES":0.76266,"NES":0.98629,"nMoreExtreme":35379,"size":17,"leadingEdge":["SRI","PSEN1"]} {"pathway":"GO_MYOBLAST_DIFFERENTIATION","pval":0.50515,"padj":0.91988,"ES":0.62767,"NES":0.98627,"nMoreExtreme":37068,"size":65,"leadingEdge":["CXCL10","CXCL9","FLT3LG","TNF","SOX8","TGFB1","RIPOR2","PLCB1","BOC"]} {"pathway":"GO_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION","pval":0.50617,"padj":0.92065,"ES":0.60175,"NES":0.98616,"nMoreExtreme":39438,"size":95,"leadingEdge":["CD74","CEACAM1","LILRB3","IRF7","LYN","CSF1","TLR3","LILRB4","NOTCH2","TNF","LILRB1","PTPN2","RUNX1","TGFB1","OCSTAMP","C1QC","CCL3","PPARGC1B"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_ENDOGENOUS_STIMULUS","pval":0.57643,"padj":0.94161,"ES":0.53867,"NES":0.98587,"nMoreExtreme":57441,"size":1066,"leadingEdge":["P2RX7","SOCS1","LRRK2","PDE4B","NOD2","CEACAM1","RXFP1","ACOD1","CHRD","SSTR2","PADI2","STAT1","JAK2","AGT","RIPK2","ONECUT2","ACSL1","XRN1","VCAM1","ICAM1","PAQR8","KLF4","BCL2L11","PML","CTSS","JAK3","P2RX4","RAPGEF2","CASP4","CASP7","EDN1","MIR503","FAM107A","CISH","COMP","PTGER4","CCL5","LYN","EPHX1","NR4A3","CTSL","GAREM1","FGF10","EGR3","HTRA4","CHST11","TNF","PTGER2","STAT5A","SLC8A1","TRIM72","HNF4G","SMPD3","NCOA1","PTAFR","NR1H3","NR4A2","KCNE1","FPR2","SOCS3","CCL2","SH2B2","STAT3","P2RY12","PTPN2","PAK1","TRIM71","GCLC","RUNX1","SRC","TGFB1","CXCL8","UCP2","ATP6V1A","PDGFRA","NAMPT","RRAGC","CDKN1C","PTPN1","P2RY2","RHOQ","SORT1","ACTN2","RGMA","CREBRF","PTGS2","HAS2","PLPP1","GPR150","ASNS","FOXC1","CFLAR","RRAGD","GATA3","AGTRAP","NKX3-1","NFE2L2","PPARGC1B","MIR212"]} {"pathway":"GO_CELL_FATE_COMMITMENT","pval":0.51511,"padj":0.92459,"ES":0.57235,"NES":0.9858,"nMoreExtreme":43944,"size":170,"leadingEdge":["IL12RB1","TBX21","ONECUT2","KLF4","PML","SLAMF6","CYLD","SLAMF8","EPOP","IL7","IRF4","IL6","FGF10","TBX19","NOTCH2","SOX8","ASCL1","STAT3","ISL2","MCL1","GATA3"]} {"pathway":"GO_SKELETAL_MUSCLE_TISSUE_REGENERATION","pval":0.53878,"padj":0.92855,"ES":0.72669,"NES":0.98558,"nMoreExtreme":34121,"size":24,"leadingEdge":["DYSF","CFLAR","MYOZ1","IFRD1"]} {"pathway":"GO_INSULIN_SECRETION","pval":0.51409,"padj":0.92459,"ES":0.57869,"NES":0.9855,"nMoreExtreme":42875,"size":146,"leadingEdge":["CD38","JAK2","SIDT2","SRI","IL1RN","CCL5","GLUL","TNF","VGF","MAFA","UCP2","NADK","CPT1A","PIM3"]} {"pathway":"GO_STARTLE_RESPONSE","pval":0.63284,"padj":0.94878,"ES":0.77751,"NES":0.98524,"nMoreExtreme":36856,"size":13,"leadingEdge":["GRIN3A","ADORA2A"]} {"pathway":"GO_PURINERGIC_RECEPTOR_SIGNALING_PATHWAY","pval":0.52635,"padj":0.92669,"ES":0.7087,"NES":0.98487,"nMoreExtreme":34000,"size":28,"leadingEdge":["P2RY14","P2RX7","P2RX4","P2RY13","PTAFR","P2RY12","P2RY2","ACPP"]} {"pathway":"GO_REGULATION_OF_GLIAL_CELL_PROLIFERATION","pval":0.5269,"padj":0.92669,"ES":0.70845,"NES":0.98452,"nMoreExtreme":34036,"size":28,"leadingEdge":["ASCL2","LYN","LTA","IL6","TNF","PTN"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INFLAMMATORY_RESPONSE","pval":0.51047,"padj":0.92413,"ES":0.59573,"NES":0.98448,"nMoreExtreme":40347,"size":103,"leadingEdge":["HGF","ACOD1","KLF4","MEFV","ZC3H12A","SLAMF8","PTGER4","TNFAIP6","TNFAIP3","DUSP10","PTPRC","NR1H3","SOCS3","PTPN2","IL2RA","CX3CL1","GATA3","IL1R2","SMAD3"]} {"pathway":"GO_MUSCLE_HYPERTROPHY","pval":0.50819,"padj":0.92274,"ES":0.62086,"NES":0.98444,"nMoreExtreme":37738,"size":70,"leadingEdge":["AGT","CAMK2D","P2RX4","EDN1","NR4A3","MYH7","PAK1","SMAD3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_DENDRITIC_CELL_ANTIGEN_PROCESSING_AND_PRESENTATION","pval":0.65413,"padj":0.94878,"ES":0.73602,"NES":0.98419,"nMoreExtreme":35106,"size":6,"leadingEdge":["CD74","NOD2","CCL19"]} {"pathway":"GO_REGULATION_OF_NEUTROPHIL_MIGRATION","pval":0.52745,"padj":0.92669,"ES":0.7082,"NES":0.98418,"nMoreExtreme":34071,"size":28,"leadingEdge":["CD74","EDN1","DYSF","SLAMF8","CAMK1D","CCL19","CXCL8","RIPOR2","DAPK2","SLIT2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_6_PRODUCTION","pval":0.51694,"padj":0.9251,"ES":0.68324,"NES":0.98408,"nMoreExtreme":34454,"size":35,"leadingEdge":["HGF","BANK1","ZC3H12A","SLAMF1","TNFAIP3","TNF","GAS6","CX3CL1","TLR4"]} {"pathway":"GO_REGULATION_OF_CELL_PROJECTION_ASSEMBLY","pval":0.51771,"padj":0.92515,"ES":0.57645,"NES":0.9839,"nMoreExtreme":43373,"size":150,"leadingEdge":["P2RX7","ICAM1","CYLD","STAP1","CDKL1","ATG3","AUTS2","P2RY12","PODXL","SRC","CDC42EP2","CCL19","RHOQ","RIPOR2","SLIT2","PPP1R16B","COBL","HAP1","WNT1","HDAC4"]} {"pathway":"GO_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS","pval":0.59776,"padj":0.94558,"ES":0.53688,"NES":0.98353,"nMoreExtreme":59718,"size":1375,"leadingEdge":["IL31RA","CD40","GBP1","CD74","P2RX7","SOCS1","LRRK2","IL15","CXCL10","NOD2","CEACAM1","CCL13","PLEK","HGF","NLRC5","BANK1","ATF3","LMTK2","JAK2","AGT","RIPK2","TLR8","STAT2","CCL7","FAS","ACSL1","SPTBN4","ICAM1","KLF4","CCL15","FLT3LG","TNFSF18","CD80","PML","FAM20A","CCL8","C3","SCIMP","ZC3H12A","CYLD","RAPGEF2","STAP1","ENPP2","RALB","BTN2A2","EDN1","VEGFC","SLAMF1","NCF1","NRK","MIR503","CISH","MVP","IL1RN","GADD45B","STAP2","GLIPR2","SLAMF8","PPM1E","CCL18","CCL5","LYN","IL12A","DTNBP1","PARP14","TLR7","CSF1","VRK2","TNFRSF14","PARP9","IL7","GAREM1","TNFAIP3","IL6","TLR3","FGF10","TXN","GADD45G","SEMA7A","NOTCH2","TNF","FLT1","DUSP10","RASGRP1","SMPD3","CCL1","FGD2","LCP2","PTPRC","CHI3L1","RHOH","CCL4","FPR2","SOCS3","CCL2","STAT3","NBN","P2RY12","PTPN2","PAK1","SRC","TGFB1","ROBO1","CCL19","CDKN1A","UVRAG","PRDX1","PDGFRA","ADAR","DUSP5","CDKN1C","PTPN1","PKHD1","CCNL1","SH3RF1","LPAR1","PTGS2","ELFN1","GAS6","CCL3","CX3CL1","CFLAR","TCIM","BIRC7","NKX3-1","SRCIN1","PPARGC1B","MIR212","SEMA4D","CCNA1","SPINK1","PLCB1","PDGFB","SMAD3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION","pval":0.51246,"padj":0.92419,"ES":0.64341,"NES":0.98254,"nMoreExtreme":36279,"size":52,"leadingEdge":["BCL6","ARHGAP25","STMN3","RIPOR2","SLIT2","HEG1","MET","ITGA3"]} {"pathway":"GO_HORMONE_BIOSYNTHETIC_PROCESS","pval":0.51248,"padj":0.92419,"ES":0.64153,"NES":0.98244,"nMoreExtreme":36388,"size":53,"leadingEdge":["HSD11B1","TNF","CYP27B1","TSPOAP1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS","pval":0.51756,"padj":0.92515,"ES":0.67028,"NES":0.98231,"nMoreExtreme":35153,"size":39,"leadingEdge":["ACOD1","AGT","ZC3H12A","TNF","FPR2","TGFB1","CDKN1A","NFE2L2","PDGFB"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELL_POPULATION_PROLIFERATION","pval":0.57474,"padj":0.94135,"ES":0.53851,"NES":0.98213,"nMoreExtreme":56695,"size":721,"leadingEdge":["HLA-DPA1","IL31RA","HLA-DMB","CD40","CD74","CD274","IL12RB1","CD38","PDCD1LG2","IL15","HLA-DPB1","CXCL10","NOD2","HLA-E","CHRD","ATF3","STAT1","JAK2","AGT","PIM1","RIPK2","TNFSF13B","VCAM1","TGM2","FLT3LG","CD80","PML","S100A13","JAK3","IL12RB2","EDN1","VEGFC","SLAMF1","MIR503","COMP","DYSF","BCL6","CCL5","LYN","IL12A","GLUL","CSF1","LTA","NR4A3","IL7","GAREM1","TNFAIP3","CTSZ","IL6","FGF10","EGR3","TNF","SOX8","STAT5A","EBI3","FLT1","HPN","CD86","CD47","SMPD3","UBE2A","ASCL1","NTN1","CXCL12","PTPRC","PTAFR","F3","STAT3","PAK1","TGFB1","OCSTAMP","CCDC88B","IL2RA","CCL19","CDKN1A","AKIRIN2","PDGFRA","NAMPT","EGR4","LIG4","PKHD1","PTGS2","HAS2","GAS6","CX3CL1","TNS3","CFLAR","ESM1","LIFR","NKX3-1","LIN28A","CCNA1"]} {"pathway":"GO_REGULATION_OF_SYNAPTIC_VESICLE_ENDOCYTOSIS","pval":0.59014,"padj":0.94238,"ES":0.7594,"NES":0.98207,"nMoreExtreme":35661,"size":17,"leadingEdge":["LRRK2","SYT7"]} {"pathway":"GO_POSITIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS","pval":0.5173,"padj":0.9251,"ES":0.66747,"NES":0.98162,"nMoreExtreme":35261,"size":40,"leadingEdge":["JAK2","AGT","ICAM1","KLF4","P2RX4","EDN1","TNF","ADGRB1","PTGS2","SMAD3","TLR4","ASS1","TICAM1","HDAC4"]} {"pathway":"GO_REGULATION_OF_ODONTOGENESIS","pval":0.62432,"padj":0.94878,"ES":0.77126,"NES":0.98151,"nMoreExtreme":36747,"size":14,"leadingEdge":["EDN1","CSF1","TGFB1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MUSCLE_HYPERTROPHY","pval":0.53386,"padj":0.92816,"ES":0.71046,"NES":0.98135,"nMoreExtreme":34326,"size":27,"leadingEdge":["AGT","CAMK2D","EDN1","NR4A3","IGF1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PLASMINOGEN_ACTIVATION","pval":0.62105,"padj":0.94878,"ES":0.71336,"NES":0.98128,"nMoreExtreme":32861,"size":5,"leadingEdge":["CTSZ","SERPINE1"]} {"pathway":"GO_ANION_TRANSPORT","pval":0.55488,"padj":0.93402,"ES":0.5444,"NES":0.98114,"nMoreExtreme":52827,"size":416,"leadingEdge":["SLC6A12","APOL1","P2RX7","CEACAM1","SLC37A1","KCNJ10","AGT","ABCC11","SLC12A3","ANO4","ACSL1","ABCB1","P2RX4","EDN1","CLIC5","CTNS","XKR6","PLSCR4","PLSCR1","SLC27A3","SLCO4A1","SLC51A","PLA2G4A","SLC25A22","SLC12A7","NCOA1","XKR8","SLC26A11","SLC25A25","SLC4A10","PTAFR","KMO","SLC7A2","CLCN4","GABRR2","GLTPD2","ABCC2","MFSD2A","XKR7","PRELID1","ADAMTS8","CLIC2","GLS","NFKBIE"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_BIOSYNTHETIC_PROCESS","pval":0.60682,"padj":0.94703,"ES":0.53563,"NES":0.98101,"nMoreExtreme":60600,"size":1266,"leadingEdge":["IRF1","ASCL2","CIITA","ETV7","CD38","LAG3","TBX21","CEACAM1","PLEK","BANK1","ATF3","NMI","STAT1","IFI27","OVOL1","BATF3","BHLHE41","XRN1","KLF4","MUC1","SAMD4A","TRIM22","PML","ZC3H12A","JAK3","RAPGEF2","ZNFX1","ATF5","IRF7","EDN1","MIR503","SBNO2","HSBP1L1","CTNS","BACH1","RELB","BCL6","NR4A3","ZMYND15","PARP3","PARP9","TFEC","NFE2L3","IL6","LILRB4","TXN","RFX5","TNF","SOX8","FST","SMPD3","MOV10","ASCL1","CYP27B1","PTPRC","NR1H3","NR4A2","LILRB1","STAT3","PTPN2","TRIM71","TGIF2","GCLC","RUNX1","SRC","TGFB1","VAX2","AKIRIN2","TXNIP","CDKN1C","STN1","CREG1","IKZF4","HOXD8","GAS6","ARID5A","FOXC1","CFLAR","GATA3","ERLIN1","NKX3-1","IRF2","PPARGC1B","LIN28A","CIR1","MIR212","SEMA4D","PLCB1","PDGFB","SMAD3","ZFP36","SIK1","MYOZ1","RORB","ZBTB42","PAX5","BCL6B","CDYL2","S100A1","ARID5B","HIC1","IRF8"]} {"pathway":"GO_MESENCHYMAL_TO_EPITHELIAL_TRANSITION","pval":0.6138,"padj":0.94703,"ES":0.76781,"NES":0.98099,"nMoreExtreme":36473,"size":15,"leadingEdge":["STAT1","GATA3"]} {"pathway":"GO_RESPIRATORY_ELECTRON_TRANSPORT_CHAIN","pval":0.51649,"padj":0.92482,"ES":0.59786,"NES":0.98089,"nMoreExtreme":40300,"size":96,"leadingEdge":["AIFM2","SLC25A22","GPD2","SDHB","NDUFAB1"]} {"pathway":"GO_REGULATION_OF_CELL_FATE_COMMITMENT","pval":0.56041,"padj":0.93517,"ES":0.73773,"NES":0.98073,"nMoreExtreme":34877,"size":21,"leadingEdge":["IL12RB1","TBX21","HNF1B"]} {"pathway":"GO_DEVELOPMENTAL_INDUCTION","pval":0.53498,"padj":0.92816,"ES":0.70994,"NES":0.98064,"nMoreExtreme":34398,"size":27,"leadingEdge":["FGF10","SOX8","ROBO1","WNT1","SIX1","HOXA11"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS","pval":0.60257,"padj":0.94684,"ES":0.76328,"NES":0.98055,"nMoreExtreme":36095,"size":16,"leadingEdge":["KLF4","MIR503","TBXA2R"]} {"pathway":"GO_MUSCLE_SYSTEM_PROCESS","pval":0.54755,"padj":0.93115,"ES":0.54886,"NES":0.98045,"nMoreExtreme":50915,"size":327,"leadingEdge":["CD38","IL15","PDE4B","SSTR2","AGT","MYOF","KCNJ2","CAMK2D","KLF4","SRI","ZC3H12A","P2RX4","EDN1","ANK2","COMP","DYSF","TIFAB","NR4A3","SSPN","KCNE5","MYH7","RNF207","STAC3","SLC8A1","DES","TRIM72","PTAFR","KCNE1","PAK1","KCNMA1","GUCY1A1","ACTN2","PTGS2","CFLAR","CLIC2","RCSD1","SMAD3","KCNE1B","MYOZ1","EDNRA","ARHGEF11"]} {"pathway":"GO_POSITIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS","pval":0.60478,"padj":0.94687,"ES":0.53544,"NES":0.98004,"nMoreExtreme":60283,"size":1095,"leadingEdge":["IDO1","CD40","CD74","P2RX7","SOCS1","CD274","IL12RB1","IL15","TBX21","CEACAM1","AMOT","HGF","CXCL9","STAT1","JAK2","AGT","PIM1","RIPK2","TNFSF13B","SPTBN4","KLF4","SCARF1","IFITM1","FLT3LG","CD80","C3","ZC3H12A","CYLD","P2RX4","RAPGEF2","SCIN","ENPP2","BTN2A2","EDN1","VEGFC","MIR503","C21orf91","S100A10","GLIPR2","HLA-G","BCL6","LYN","CSF1","LTA","IL7","NRCAM","SOD2","CD83","TNFAIP3","ANXA3","B4GALT5","IL6","TLR3","LILRB4","FGF10","EGR3","SEMA7A","TNF","SOX8","FST","FLT1","SLC8A1","HPN","ADM2","DUSP10","CD86","RASGRP1","CAMK1D","NCOA1","ASCL1","NTN1","CXCL12","CYP27B1","PTPRC","CHI3L1","F3","SOCS3","STAT3","P2RY12","PAK1","ANGPTL4","TGIF2","RUNX1","SRC","TGFB1","SEMA4A","OCSTAMP","ROBO1","IL2RA","CCL19","CGAS","CXCL8","ADGRB1","LIG4","ISG15","LPAR1","GPM6B","PTGS2","RIPOR2","ADAMTS20","HAS2","GAS6","CCL3","CX3CL1","FOXC1","CFLAR","GATA3","NFE2L2","PPARGC1B","LIN28A","SEMA4D","CD53","ERAP1","PLCB1","PDGFB","SMAD3","SYT17","ZFP36","SLIT2","IL1A","DDHD1","BOC","HLX","NGF","ESRRB","PPP1R16B","S100A1","FLOT1"]} {"pathway":"GO_ERYTHROCYTE_HOMEOSTASIS","pval":0.52042,"padj":0.9256,"ES":0.5934,"NES":0.97972,"nMoreExtreme":41077,"size":102,"leadingEdge":["STAT1","JAK2","B2M","JAK3","BCL6","LYN","STAT3","PTPN2","PRDX1","ISG15","GATA3","ZFP36"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_DSRNA","pval":0.5618,"padj":0.93517,"ES":0.73692,"NES":0.97965,"nMoreExtreme":34964,"size":21,"leadingEdge":["P2RX7","RALB","IFIH1","TLR3","DDX58","CGAS","FLOT1"]} {"pathway":"GO_RESPONSE_TO_CISPLATIN","pval":0.67376,"padj":0.94976,"ES":0.74876,"NES":0.97943,"nMoreExtreme":36622,"size":7,"leadingEdge":["NUCB1","SLC31A1"]} {"pathway":"GO_HEMATOPOIETIC_STEM_CELL_MIGRATION","pval":0.62148,"padj":0.94878,"ES":0.71201,"NES":0.97943,"nMoreExtreme":32884,"size":5,"leadingEdge":["PTPRC","GAS6","GPLD1"]} {"pathway":"GO_RESPONSE_TO_PROTOZOAN","pval":0.6153,"padj":0.94794,"ES":0.76654,"NES":0.97937,"nMoreExtreme":36562,"size":15,"leadingEdge":["CD40","BATF2","TSPAN32","IRF4","CCDC88B","IRF8"]} {"pathway":"GO_LONG_CHAIN_FATTY_ACID_IMPORT_INTO_CELL","pval":0.63807,"padj":0.94878,"ES":0.77284,"NES":0.97932,"nMoreExtreme":37161,"size":13,"leadingEdge":["ACSL1","SLC27A5"]} {"pathway":"GO_RESPONSE_TO_ORGANOPHOSPHORUS","pval":0.52221,"padj":0.9256,"ES":0.59063,"NES":0.97886,"nMoreExtreme":41484,"size":106,"leadingEdge":["P2RX7","SELL","STAT1","P2RX4","RAPGEF2","SLC8A1","VGF","PTAFR","KCNE1","P2RY12","P2RY2","LPAR1","PTGS2","PPARGC1B"]} {"pathway":"GO_FC_RECEPTOR_MEDIATED_STIMULATORY_SIGNALING_PATHWAY","pval":0.51923,"padj":0.92533,"ES":0.60797,"NES":0.97879,"nMoreExtreme":39401,"size":80,"leadingEdge":["LYN","NR4A3","PLSCR1","CD226","CD47","PTPRC","FCGR1A","PAK1","SRC","ELMO2","FCER1G","LIMK1"]} {"pathway":"GO_MODIFICATION_BY_SYMBIONT_OF_HOST_MORPHOLOGY_OR_PHYSIOLOGY","pval":0.52185,"padj":0.9256,"ES":0.66551,"NES":0.97873,"nMoreExtreme":35571,"size":40,"leadingEdge":["BCL2L11","CCL8","ZC3H12A","KPNA5","SERPINB9","TGFB1","SMAD3","EIF2AK2"]} {"pathway":"GO_RAB_PROTEIN_SIGNAL_TRANSDUCTION","pval":0.51902,"padj":0.92533,"ES":0.62652,"NES":0.97872,"nMoreExtreme":37801,"size":62,"leadingEdge":["RAB20","RAB24","RAB38","RAB39A","RAB2B","RAB43"]} {"pathway":"GO_ACTION_POTENTIAL","pval":0.52149,"padj":0.9256,"ES":0.59834,"NES":0.97849,"nMoreExtreme":40508,"size":93,"leadingEdge":["KCNJ2","CAMK2D","SRI","P2RX4","ANK2","KCNE5","NRCAM","RNF207","SLC8A1","SCN9A","KCNE1","CACNA1I","KCNE1B"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SMALL_MOLECULE_METABOLIC_PROCESS","pval":0.51945,"padj":0.92533,"ES":0.63889,"NES":0.9784,"nMoreExtreme":36883,"size":53,"leadingEdge":["CEACAM1","PLEK","DGAT2","CYP27B1","ERLIN1","SIK1","INSIG2","PROX1"]} {"pathway":"GO_DIOL_BIOSYNTHETIC_PROCESS","pval":0.58563,"padj":0.94167,"ES":0.75119,"NES":0.97832,"nMoreExtreme":35630,"size":18,"leadingEdge":["GCH1","EPHX1","SPHK2"]} {"pathway":"GO_EMBRYONIC_CAMERA_TYPE_EYE_DEVELOPMENT","pval":0.53504,"padj":0.92816,"ES":0.6999,"NES":0.97784,"nMoreExtreme":34720,"size":29,"leadingEdge":["FGF10","ALDH1A2","PROX1","HIPK2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY","pval":0.52228,"padj":0.9256,"ES":0.65787,"NES":0.97779,"nMoreExtreme":35962,"size":43,"leadingEdge":["NOD2","FGF10","ASCL1","STAT3","ROBO1","MIR212","SLC35C2","WNT1","MAML2"]} {"pathway":"GO_RESPONSE_TO_AMINO_ACID_STARVATION","pval":0.52217,"padj":0.9256,"ES":0.6508,"NES":0.97758,"nMoreExtreme":36344,"size":46,"leadingEdge":["ATF3","FAS","CDKN1A","UCP2","RRAGC","RRAGD","EIF2AK2","BMT2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT","pval":0.54632,"padj":0.93112,"ES":0.55617,"NES":0.9775,"nMoreExtreme":48751,"size":236,"leadingEdge":["HGF","AGT","SCARF1","RAPGEF2","C21orf91","LYN","SEMA7A","CAMK1D","NTN1","CXCL12","PAK1","ROBO1","LPAR1","CX3CL1","CFLAR","NFE2L2","SEMA4D","SYT17","SLIT2","NGF","RUFY3","COBL","LIMK1","PTN"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_MEMBRANE","pval":0.57873,"padj":0.94163,"ES":0.53868,"NES":0.97748,"nMoreExtreme":56208,"size":547,"leadingEdge":["GBP1","VAMP5","OPTN","SPTBN4","RTP4","BCL2L11","RAPGEF2","NCF1","PMAIP1","ANK2","S100A10","COLQ","FYB1","ZDHHC19","TMEM150A","STAC3","TNF","ZDHHC18","ITGAL","ZDHHC11B","ATG3","KCNE1","ITGB7","PAK1","TGFB1","RHOQ","ACTN2","PLEKHF1","AMN","GAS6","BBC3","RILPL1","RAB38","STX3","STOM","FCER1G","SHISA7","FLOT1","RAPSN","ZDHHC23","NPC1"]} {"pathway":"GO_REGULATION_OF_LIPID_LOCALIZATION","pval":0.52605,"padj":0.92669,"ES":0.59241,"NES":0.97712,"nMoreExtreme":41441,"size":101,"leadingEdge":["P2RX7","AGT","C3","ZC3H12A","P2RX4","EDN1","TTC39B","IL6","TNF","LIPG","NR1H3","PTPN2","IKBKE","NFKBIA","PRELID1","NKX3-1"]} {"pathway":"GO_CELLULAR_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY","pval":0.60864,"padj":0.94703,"ES":0.53446,"NES":0.97696,"nMoreExtreme":60453,"size":909,"leadingEdge":["GBP5","HLA-DMA","HLA-DMB","HLA-DRA","HLA-DRB1","PSTPIP2","MSRB1","JAK2","ERC2","TAPBP","SPTBN4","ICAM1","DNAAF1","LRRC61","PRRT2","POMP","MEFV","SCIN","RALB","TMSB10","FAM107A","SCO2","CADPS2","FCHO1","HOPX","PDE4DIP","MX1","ACTR3C","PAK1","TRIM9","SRC","TGFB1","CDC42EP2","UVRAG","ADAR","MAP2","PRPF3","TPPP"]} {"pathway":"GO_ENDOCRINE_PANCREAS_DEVELOPMENT","pval":0.5318,"padj":0.92816,"ES":0.68823,"NES":0.97675,"nMoreExtreme":34972,"size":32,"leadingEdge":["ONECUT2","SIDT2","IL6","BAK1","BAD"]} {"pathway":"GO_REGULATION_OF_RESPIRATORY_SYSTEM_PROCESS","pval":0.6728,"padj":0.94963,"ES":0.76898,"NES":0.97624,"nMoreExtreme":37976,"size":10,"leadingEdge":["GLS","MTG2"]} {"pathway":"GO_ACTIVIN_RECEPTOR_SIGNALING_PATHWAY","pval":0.53917,"padj":0.92855,"ES":0.70239,"NES":0.97611,"nMoreExtreme":34828,"size":28,"leadingEdge":["FGF10","FST","TGIF2","SMAD3","ZC3H3"]} {"pathway":"GO_NCRNA_TRANSCRIPTION","pval":0.52708,"padj":0.92669,"ES":0.59369,"NES":0.97603,"nMoreExtreme":41278,"size":98,"leadingEdge":["ELL2","GTF2B","POLR2J"]} {"pathway":"GO_MAINTENANCE_OF_PROTEIN_LOCALIZATION_IN_ORGANELLE","pval":0.52918,"padj":0.92669,"ES":0.67439,"NES":0.97568,"nMoreExtreme":35448,"size":36,"leadingEdge":["PML","TXN","HSPA5"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_GTPASE_ACTIVITY","pval":0.526,"padj":0.92669,"ES":0.65872,"NES":0.97552,"nMoreExtreme":36069,"size":42,"leadingEdge":["LRRK2","AMOT","RHOH","SLIT2"]} {"pathway":"GO_REGULATION_OF_TAU_PROTEIN_KINASE_ACTIVITY","pval":0.67869,"padj":0.94976,"ES":0.76371,"NES":0.97548,"nMoreExtreme":37927,"size":9,"leadingEdge":["HGF","HSP90AA1"]} {"pathway":"GO_MECHANOSENSORY_BEHAVIOR","pval":0.67344,"padj":0.94976,"ES":0.76817,"NES":0.97522,"nMoreExtreme":38012,"size":10,"leadingEdge":["TIFAB","NEUROG1"]} {"pathway":"GO_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC","pval":0.55887,"padj":0.93517,"ES":0.54911,"NES":0.975,"nMoreExtreme":51136,"size":288,"leadingEdge":["PADI2","ZC3H12A","ZNFX1","MIR503","MOV10","STAT3","TRIM71","TGFB1","TAF1A","ADAR","PCGF5","LIN28A","MIR212","SMAD3","ZFP36","KDM1B"]} {"pathway":"GO_POSITIVE_REGULATION_OF_GENE_EXPRESSION","pval":0.65088,"padj":0.94878,"ES":0.53205,"NES":0.97496,"nMoreExtreme":65060,"size":1575,"leadingEdge":["IRF1","IL31RA","ASCL2","CD40","CD74","P2RX7","CIITA","CD38","LAMP3","TBX21","CXCL10","NOD2","HGF","NLRC5","EGR2","ATF3","PADI2","STAT1","AGT","RIPK2","ONECUT2","OVOL1","CASZ1","KLF4","MUC1","ARNTL2","SAMD4A","FLT3LG","CD80","ZC3H12A","EBF4","STAP1","ATF5","IRF7","EDN1","NCF1","DTX3L","SBNO2","ANK2","MAFF","BACH1","RELB","LITAF","CCL5","PYHIN1","DTNBP1","CSF1","NR4A3","PARP9","TFEC","PLSCR1","IRF4","RNF207","NFE2L3","MYD88","IL6","TLR3","FGF10","RFX5","EGR3","TBX19","NFKB2","TNF","SOX8","HPN","SERPINB9","ADM2","CD86","HELZ2","HNF4G","MOV10","NCOA1","ASCL1","PTAFR","DDX58","NR1H3","NR4A2","AUTS2","LILRB1","KLF6","MAFA","STAT3","MACC1","RUNX1","SRC","TGFB1","ROBO1","STAT4","AKIRIN2","NAMPT","TAF1A","CDKN1C","RHOQ","NFKBIA","RGMA","EGR4","CREBRF","PLGRKT","IKZF4","HOXD8","GAS6","CCL3","IRF5","CX3CL1","FOXC1","GATA3","ERLIN1","PCGF5","NKX3-1","IRF2","NFE2L2","IL33","PPARGC1B","LIN28A","MIR212"]} {"pathway":"GO_REGULATION_OF_VASOCONSTRICTION","pval":0.53219,"padj":0.92816,"ES":0.67999,"NES":0.97485,"nMoreExtreme":35329,"size":34,"leadingEdge":["CD38","AGT","ICAM1","EDN1","PTAFR","PTGS2"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_MICROTUBULE_ORGANIZING_CENTER","pval":0.5367,"padj":0.92816,"ES":0.69054,"NES":0.97478,"nMoreExtreme":35134,"size":31,"leadingEdge":["SNX10","MARK4"]} {"pathway":"GO_POLYOL_METABOLIC_PROCESS","pval":0.5243,"padj":0.92669,"ES":0.62895,"NES":0.9747,"nMoreExtreme":37761,"size":58,"leadingEdge":["GK","MYOF","DGAT2","DYSF","PLCB1"]} {"pathway":"GO_RESPONSE_TO_AMYLOID_BETA","pval":0.53157,"padj":0.92816,"ES":0.6766,"NES":0.97451,"nMoreExtreme":35429,"size":35,"leadingEdge":["VCAM1","ICAM1","CASP4","FPR2","NAMPT","TLR4"]} {"pathway":"GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_CLEARANCE","pval":0.54686,"padj":0.93115,"ES":0.70971,"NES":0.97438,"nMoreExtreme":34989,"size":26,"leadingEdge":["SOAT1","DGAT2","NPC1","EHD1"]} {"pathway":"GO_RESPONSE_TO_FIBROBLAST_GROWTH_FACTOR","pval":0.53286,"padj":0.92816,"ES":0.5837,"NES":0.97435,"nMoreExtreme":42825,"size":115,"leadingEdge":["MIR503","CCL5","FGF10","EGR3","CCL2","TRIM71","GCLC","CXCL8","GATA3","ZFP36","SHISA2","TBX1","GALNT3"]} {"pathway":"GO_ENDOCYTOSIS","pval":0.58113,"padj":0.94167,"ES":0.53902,"NES":0.97425,"nMoreExtreme":55775,"size":461,"leadingEdge":["APOL1","LRRK2","SNX10","CEACAM1","CLEC9A","SCARF1","B2M","C3","CLEC10A","LGALS3BP","STAP1","RAB20","ENPP2","IGF2R","LY75","ANK2","XKR6","DENND1B","CXCL16","ARHGAP25","FCHO1","XKR8","NR1H3","LILRB1","FPR2","ACKR4","FCGR1A","MYO1E","SRC","SYT5","CCL19","CXCL8","PTPN1","RHOQ","SORT1","ADGRB1","FNBP1","AMN","XKR7","FCGR1B","ANKRD13A","DNAJC13","SYT17","ILDR1","FCER1G","C9orf72","FLOT1","ARC","RINL","NPC1"]} {"pathway":"GO_FATTY_ACYL_COA_METABOLIC_PROCESS","pval":0.65698,"padj":0.94878,"ES":0.7284,"NES":0.974,"nMoreExtreme":35259,"size":6,"leadingEdge":["DGAT2","FAR2"]} {"pathway":"GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_MEDIATED_BY_A_CHEMICAL_SIGNAL","pval":0.53781,"padj":0.92855,"ES":0.68999,"NES":0.974,"nMoreExtreme":35207,"size":31,"leadingEdge":["SUCNR1","AGT","EDN1","SOD2","CTSZ","CES1"]} {"pathway":"GO_POST_EMBRYONIC_ANIMAL_ORGAN_DEVELOPMENT","pval":0.6207,"padj":0.94878,"ES":0.76233,"NES":0.97399,"nMoreExtreme":36883,"size":15,"leadingEdge":["KLF4","BCL2L11","MYO1E","BAK1","ERCC1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_HAIR_CYCLE","pval":0.50691,"padj":0.92131,"ES":0.66084,"NES":0.97361,"nMoreExtreme":25913,"size":3,"leadingEdge":["CDH3","FERMT1","SMO"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PRI_MIRNA_TRANSCRIPTION_BY_RNA_POLYMERASE_II","pval":0.65416,"padj":0.94878,"ES":0.76881,"NES":0.97356,"nMoreExtreme":37733,"size":12,"leadingEdge":["LILRB4","PDGFB","HDAC4"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS","pval":0.55853,"padj":0.93517,"ES":0.55188,"NES":0.97317,"nMoreExtreme":50255,"size":251,"leadingEdge":["SERPING1","CEACAM1","HGF","KREMEN1","ACOD1","PADI2","GRIN3A","KLF4","MEFV","ZC3H12A","STAP1","CARD16","EDN1","LILRA2","SLAMF8","PTGER4","TNFAIP6","TNFAIP3","SEMA7A","DUSP10","GPR18","PTPRC","NR1H3","SOCS3","CCL2","PTPN2","DHX58","SEMA4A","ROBO1","IL2RA","CDKN1A","GP1BA","PDGFRA","RGMA","CX3CL1","GATA3","SEMA4D","IL1R2","PDGFB","SMAD3","MICB","SLIT2","MYOZ1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_CHEMOTAXIS","pval":0.63195,"padj":0.94878,"ES":0.76457,"NES":0.97299,"nMoreExtreme":37196,"size":14,"leadingEdge":["P2RX4","MET"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY","pval":0.56832,"padj":0.93754,"ES":0.68311,"NES":0.97278,"nMoreExtreme":29578,"size":4,"leadingEdge":["F3","SRC","HIP1R"]} {"pathway":"GO_EPOXYGENASE_P450_PATHWAY","pval":0.62282,"padj":0.94878,"ES":0.70716,"NES":0.97276,"nMoreExtreme":32955,"size":5,"leadingEdge":["CYP1A1","EPHX2"]} {"pathway":"GO_COVALENT_CHROMATIN_MODIFICATION","pval":0.58003,"padj":0.94163,"ES":0.53998,"NES":0.9725,"nMoreExtreme":55116,"size":408,"leadingEdge":["LRRK2","PADI2","JAK2","CAMK2D","MUC1","JADE2","DTX3L","BAZ1A","BCL6","EPOP","IRF4","AURKC","ATXN7","UBE2A","NCOA1","AUTS2","TGFB1","GATA3","PCGF5","NEK11","KDM1B","PAX5","GTF2B","MTHFR"]} {"pathway":"GO_PROTEIN_ACYLATION","pval":0.55464,"padj":0.93396,"ES":0.55562,"NES":0.97237,"nMoreExtreme":48968,"size":218,"leadingEdge":["MUC1","JADE2","BAZ1A","ZDHHC19","GLUL","IRF4","ZDHHC18","NCOA1","ZDHHC11B","AUTS2","TGFB1","GATA3","NUPR1","ZDHHC23","GTF2B"]} {"pathway":"GO_REGULATION_OF_PROTEIN_ADP_RIBOSYLATION","pval":0.65776,"padj":0.94878,"ES":0.72713,"NES":0.97231,"nMoreExtreme":35301,"size":6,"leadingEdge":["PNKP","HPF1","XRCC1","PUM3","ADNP","KAT2B"]} {"pathway":"GO_EMBRYONIC_SKELETAL_SYSTEM_MORPHOGENESIS","pval":0.53101,"padj":0.92816,"ES":0.61303,"NES":0.97203,"nMoreExtreme":39432,"size":70,"leadingEdge":["CHST11","AUTS2","PDGFRA","SMAD3","PAX5","TBX1","SIX1","HOXA11"]} {"pathway":"GO_POSITIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION","pval":0.53109,"padj":0.92816,"ES":0.64706,"NES":0.97198,"nMoreExtreme":36965,"size":46,"leadingEdge":["CXCL9","FLT3LG","EDN1","TGFB1","ADGRB1","RIPOR2","CD53","FLOT1","TBX1","PROX1","EHD1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_GLUCOSE_TRANSMEMBRANE_TRANSPORT","pval":0.53869,"padj":0.92855,"ES":0.68483,"NES":0.97194,"nMoreExtreme":35425,"size":32,"leadingEdge":["C3","NR4A3","RHOQ","NFE2L2","ADIPOR2"]} {"pathway":"GO_MYELOID_CELL_APOPTOTIC_PROCESS","pval":0.54523,"padj":0.93104,"ES":0.69925,"NES":0.97174,"nMoreExtreme":35220,"size":28,"leadingEdge":["NOD2","HCAR2","IRF7","CTSL","IL6","CCR5","FCER1G"]} {"pathway":"GO_CENTRAL_NERVOUS_SYSTEM_NEURON_DEVELOPMENT","pval":0.53199,"padj":0.92816,"ES":0.61938,"NES":0.97137,"nMoreExtreme":38958,"size":64,"leadingEdge":["SPTBN4","RAPGEF2","ATF5","B4GALT5","ASCL1","SLC4A10","NR4A2","AUTS2","ROBO1","MAP2","SLIT2","BTG2"]} {"pathway":"GO_REGULATION_OF_CARBOHYDRATE_BIOSYNTHETIC_PROCESS","pval":0.53266,"padj":0.92816,"ES":0.60505,"NES":0.97129,"nMoreExtreme":40234,"size":78,"leadingEdge":["PLEK","DGAT2","SMPD3","PTAFR","PTPN2","TGFB1","HAS2","PDGFB","SIK1","ESRRB","CD244"]} {"pathway":"GO_DICARBOXYLIC_ACID_CATABOLIC_PROCESS","pval":0.66736,"padj":0.94905,"ES":0.76674,"NES":0.97094,"nMoreExtreme":38105,"size":11,"leadingEdge":["ACOT4","GLUL","ACOT8"]} {"pathway":"GO_POSITIVE_REGULATION_OF_JUN_KINASE_ACTIVITY","pval":0.53321,"padj":0.92816,"ES":0.61538,"NES":0.97077,"nMoreExtreme":39329,"size":67,"leadingEdge":["RIPK2","EDN1","NRK","TNF","FGD2","PAK1","CCL19","PTPN1","BIRC7"]} {"pathway":"GO_VITAMIN_BIOSYNTHETIC_PROCESS","pval":0.58581,"padj":0.94167,"ES":0.74028,"NES":0.97071,"nMoreExtreme":35978,"size":19,"leadingEdge":["TNF","CYP27B1","MMAA","RFK","SNAI2"]} {"pathway":"GO_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE","pval":0.5386,"padj":0.92855,"ES":0.58368,"NES":0.97064,"nMoreExtreme":43017,"size":110,"leadingEdge":["ATF3","BCL2L11","EDEM1","CCL2","PTPN2","CXCL8","PTPN1","CREBRF","ASNS","NFE2L2","HERPUD1","BAK1"]} {"pathway":"GO_DIGESTIVE_SYSTEM_PROCESS","pval":0.53277,"padj":0.92816,"ES":0.63073,"NES":0.97043,"nMoreExtreme":38034,"size":55,"leadingEdge":["SNX10","NOD2","TYMP","GCNT3","TIFAB","FGF10","NR1H3","TLR4","SLC9A4","NEUROG1"]} {"pathway":"GO_BUD_ELONGATION_INVOLVED_IN_LUNG_BRANCHING","pval":0.67724,"padj":0.94976,"ES":0.74185,"NES":0.9704,"nMoreExtreme":36811,"size":7,"leadingEdge":["FGF10","FGFR2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_B_CELL_APOPTOTIC_PROCESS","pval":0.66774,"padj":0.94905,"ES":0.76631,"NES":0.97038,"nMoreExtreme":38127,"size":11,"leadingEdge":["CD74","BCL6"]} {"pathway":"GO_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY_COUPLED_TO_CYCLIC_NUCLEOTIDE_SECOND_MESSENGER","pval":0.54618,"padj":0.93112,"ES":0.57201,"NES":0.97034,"nMoreExtreme":45207,"size":139,"leadingEdge":["CXCL11","CXCL10","ADGRE5","RXFP1","CXCL9","SSTR2","AGT","GRM8","RAPGEF2","EDN1","ADGRG5","PTGER4","PTGER2","ADM2","FPR2","CCL2","P2RY12","AKAP12","ADGRB1","LPAR1","RGS1"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_CADMIUM_ION","pval":0.54541,"padj":0.93112,"ES":0.69045,"NES":0.96974,"nMoreExtreme":35554,"size":30,"leadingEdge":["NCF1","MT2A","MT1M","MT1E","MT1H","MT1G"]} {"pathway":"GO_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS","pval":0.59969,"padj":0.94564,"ES":0.53578,"NES":0.96944,"nMoreExtreme":57745,"size":483,"leadingEdge":["IDO1","GCH1","GK","PLEK","IDO2","PLAAT3","ACSL1","VPS9D1","PARP10","NPR1","PCYT1A","CMPK2","CDS1","PARP9","PLSCR1","KYNU","LPCAT2","PLA2G4A","ACSL5","PTAFR","FPR2","ELOVL7","KMO","STAT3","GUCA1A","TGFB1","AGPAT3","ACSS1","NAMPT","GUCY1A1","PTGS2","MFSD2A","GUCY1B1","SLC44A2","AK4","PLCB1","NADK","PDGFB","RAB38"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_WOUNDING","pval":0.53567,"padj":0.92816,"ES":0.61812,"NES":0.96939,"nMoreExtreme":39227,"size":64,"leadingEdge":["SERPING1","CEACAM1","KREMEN1","EDN1","DUSP10","CDKN1A","GP1BA","PDGFRA","RGMA","PDGFB","SMAD3","MYOZ1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_10_PRODUCTION","pval":0.6256,"padj":0.94878,"ES":0.75856,"NES":0.96917,"nMoreExtreme":37174,"size":15,"leadingEdge":["IDO1","CD274","PDCD1LG2","JAK3","LILRB1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CATABOLIC_PROCESS","pval":0.56982,"padj":0.93919,"ES":0.54917,"NES":0.96914,"nMoreExtreme":51369,"size":255,"leadingEdge":["LRRK2","LAMP3","HGF","ATP13A2","HCAR2","PML","DYSF","MYD88","TNF","AZIN2","STAT3","NAMPT","MCL1","ADGRB1","SMAD3","ZFP36","AGAP2","NPC1","MET","TENT5C","LZTS1","WNT1","HDAC4"]} {"pathway":"GO_MULTICELLULAR_ORGANISMAL_SIGNALING","pval":0.54919,"padj":0.93134,"ES":0.57203,"NES":0.96895,"nMoreExtreme":45323,"size":136,"leadingEdge":["ATP1B2","AGT","KCNJ2","CAMK2D","TYMP","SPTBN4","SRI","P2RX4","NPR1","GJD3","ANK2","KCNE5","NRCAM","RNF207","SLC8A1","SCN9A","KCNE1","CACNA1I"]} {"pathway":"GO_MATERNAL_PROCESS_INVOLVED_IN_FEMALE_PREGNANCY","pval":0.53568,"padj":0.92816,"ES":0.63583,"NES":0.96886,"nMoreExtreme":37843,"size":51,"leadingEdge":["APOL2","UBE2A","CYP27B1","PTGS2","JUNB"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MUSCLE_ADAPTATION","pval":0.68259,"padj":0.94976,"ES":0.75806,"NES":0.96828,"nMoreExtreme":38145,"size":9,"leadingEdge":["KLF4","SMAD3","ATP2B4"]} {"pathway":"GO_CELL_PROLIFERATION_IN_HINDBRAIN","pval":0.66953,"padj":0.94905,"ES":0.76442,"NES":0.968,"nMoreExtreme":38229,"size":11,"leadingEdge":["ATF5","RERE"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_VASCULAR_ASSOCIATED_SMOOTH_MUSCLE_CELL_APOPTOTIC_PROCESS","pval":0.48809,"padj":0.91689,"ES":0.64896,"NES":0.96796,"nMoreExtreme":24527,"size":2,"leadingEdge":["IGF1","DNMT1"]} {"pathway":"GO_REGULATION_OF_MELANIN_BIOSYNTHETIC_PROCESS","pval":0.68286,"padj":0.94976,"ES":0.74965,"NES":0.96758,"nMoreExtreme":37625,"size":8,"leadingEdge":["RAPGEF2","CDH3"]} {"pathway":"GO_PROTEIN_KINASE_C_SIGNALING","pval":0.56577,"padj":0.93517,"ES":0.71793,"NES":0.96748,"nMoreExtreme":35596,"size":23,"leadingEdge":["CD40","PLEK","AKAP12","SEZ6L","PDGFB","FLOT1"]} {"pathway":"GO_T_CELL_HOMEOSTASIS","pval":0.54698,"padj":0.93115,"ES":0.68526,"NES":0.96732,"nMoreExtreme":35807,"size":31,"leadingEdge":["P2RX7","BCL2L11","JAK3","PMAIP1","TGFB1","IL2RA"]} {"pathway":"GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL","pval":0.56237,"padj":0.93517,"ES":0.71317,"NES":0.96725,"nMoreExtreme":35615,"size":24,"leadingEdge":["CAMK2D","ANK2","RNF207","DSG2"]} {"pathway":"GO_REGULATION_OF_HORMONE_LEVELS","pval":0.58719,"padj":0.94167,"ES":0.54019,"NES":0.96717,"nMoreExtreme":54958,"size":346,"leadingEdge":["CD38","HCAR2","JAK2","AGT","CYP1A1","SIDT2","SRI","HSD11B1","EDN1","DHRS9","IL1RN","DGAT2","COLQ","EXOC3L1","CCL5","LYN","GLUL","SLCO4A1","CTSZ","IL6","TNF","SOX8","HPN","VGF","SMPD3","CYP27B1","MAFA","SLC22A1","UCP2","PDGFRA","CES1","GATA3","NKX3-1","NADK","ILDR1","SCPEP1","NGF"]} {"pathway":"GO_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY","pval":0.54625,"padj":0.93112,"ES":0.58349,"NES":0.96703,"nMoreExtreme":43394,"size":106,"leadingEdge":["LRRK2","PLEK","C3","EDN1","DYNLT1","CCL5","DTNBP1","GUCA1A","CXCL8","RGS1","ACPP","RGS9","PLCB1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_KINASE_ACTIVITY","pval":0.60902,"padj":0.94703,"ES":0.53405,"NES":0.96675,"nMoreExtreme":58721,"size":492,"leadingEdge":["CD40","CD74","P2RX7","SOCS1","LRRK2","NOD2","HGF","JAK2","AGT","RIPK2","ACSL1","FAM20A","RAPGEF2","STAP1","RALB","EDN1","NCF1","NRK","GADD45B","CCL5","LYN","CSF1","TLR3","FGF10","TXN","GADD45G","TNF","FLT1","RASGRP1","FGD2","LCP2","PTPRC","CHI3L1","FPR2","NBN","P2RY12","PAK1","SRC","TGFB1","ROBO1","CCL19","CDKN1A","PDGFRA","DUSP5","PTPN1","LPAR1","GAS6","TCIM","BIRC7","SRCIN1"]} {"pathway":"GO_CELL_MATRIX_ADHESION","pval":0.56321,"padj":0.93517,"ES":0.55764,"NES":0.96674,"nMoreExtreme":48693,"size":187,"leadingEdge":["LYPD5","ITGA7","ONECUT2","VCAM1","BCL2L11","FAM107A","S100A10","BCL6","CSF1","ITGAL","ITGB7","SRC","ACTN2","GPM6B","CX3CL1","TECTA","SMAD3"]} {"pathway":"GO_EPITHELIAL_CILIUM_MOVEMENT","pval":0.60819,"padj":0.94703,"ES":0.74749,"NES":0.96667,"nMoreExtreme":36752,"size":17,"leadingEdge":["DNAAF1","GAS8","OFD1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SYNAPTIC_VESICLE_RECYCLING","pval":0.68345,"padj":0.94976,"ES":0.74856,"NES":0.96618,"nMoreExtreme":37658,"size":8,"leadingEdge":["LRRK2","DNM1L"]} {"pathway":"GO_POSITIVE_REGULATION_OF_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS","pval":0.54484,"padj":0.93088,"ES":0.66764,"NES":0.96591,"nMoreExtreme":36497,"size":36,"leadingEdge":["BCL2L11","PMAIP1","EDEM1","PTPN2","PTPN1","NFE2L2","HERPUD1","BAK1","EDEM2"]} {"pathway":"GO_REGULATION_OF_NEUROINFLAMMATORY_RESPONSE","pval":0.55415,"padj":0.93396,"ES":0.69486,"NES":0.96563,"nMoreExtreme":35796,"size":28,"leadingEdge":["LRRK2","STAP1","IL6","TNF","PTPRC","CCL3","CX3CL1","IL33"]} {"pathway":"GO_CELLULAR_MODIFIED_AMINO_ACID_BIOSYNTHETIC_PROCESS","pval":0.54478,"padj":0.93088,"ES":0.66138,"NES":0.96499,"nMoreExtreme":36836,"size":38,"leadingEdge":["GCH1","CNDP2","GGT5","CHAC1","PLSCR1","GCLC","NFE2L2"]} {"pathway":"GO_NAD_METABOLIC_PROCESS","pval":0.58586,"padj":0.94167,"ES":0.7309,"NES":0.96493,"nMoreExtreme":36214,"size":20,"leadingEdge":["CD38","KMO","NADK","MDH1"]} {"pathway":"GO_CYCLIC_NUCLEOTIDE_MEDIATED_SIGNALING","pval":0.55618,"padj":0.93517,"ES":0.57221,"NES":0.96479,"nMoreExtreme":45516,"size":129,"leadingEdge":["CXCL11","CXCL10","ADGRE5","RXFP1","CXCL9","RAPGEF2","NPR1","ADGRG5","PTGER4","PTGER2","ADM2","GUCA1A","CGAS","ADGRB1","LPAR1","GUCY1B1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELLULAR_CATABOLIC_PROCESS","pval":0.57238,"padj":0.94008,"ES":0.55232,"NES":0.96468,"nMoreExtreme":50295,"size":211,"leadingEdge":["LRRK2","LAMP3","HGF","ATP13A2","PML","MYD88","STAT3","NAMPT","MCL1","ZFP36","NPC1","MET","TENT5C","LZTS1","WNT1"]} {"pathway":"GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS","pval":0.54419,"padj":0.93088,"ES":0.6174,"NES":0.96448,"nMoreExtreme":39634,"size":62,"leadingEdge":["CD40","TBX21","POLB","BCL6","PARP3","PTPRC","NBN","TGFB1","CCR6","LIG4"]} {"pathway":"GO_TETRAHYDROBIOPTERIN_BIOSYNTHETIC_PROCESS","pval":0.67939,"padj":0.94976,"ES":0.73732,"NES":0.96447,"nMoreExtreme":36928,"size":7,"leadingEdge":["GCH1","SPR"]} {"pathway":"GO_TETRAHYDROFOLATE_BIOSYNTHETIC_PROCESS","pval":0.67939,"padj":0.94976,"ES":0.73732,"NES":0.96447,"nMoreExtreme":36928,"size":7,"leadingEdge":["GCH1","MTHFD1"]} {"pathway":"GO_POST_EMBRYONIC_DEVELOPMENT","pval":0.54641,"padj":0.93112,"ES":0.59885,"NES":0.96411,"nMoreExtreme":41464,"size":80,"leadingEdge":["KLF4","BCL2L11","ATF5","IGF2R","CHST11","SCN9A","SLC4A10","NR4A2","MYO1E","GATA3","BAK1","ARID5B","HEG1"]} {"pathway":"GO_ASCENDING_AORTA_DEVELOPMENT","pval":0.57005,"padj":0.93921,"ES":0.67683,"NES":0.96384,"nMoreExtreme":29668,"size":4,"leadingEdge":["TGFB2","LOX","HES1","SOX4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT","pval":0.54362,"padj":0.93045,"ES":0.62931,"NES":0.96373,"nMoreExtreme":38599,"size":53,"leadingEdge":["CXCL11","CXCL10","CXCL9","SRI","ANK2","STAC3","CX3CL1","S100A1","HAP1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA","pval":0.55753,"padj":0.93517,"ES":0.69325,"NES":0.9634,"nMoreExtreme":36014,"size":28,"leadingEdge":["TNFSF10","BCL2L11","PMAIP1","BBC3","BAK1","BAD"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_GLIOGENESIS","pval":0.55429,"padj":0.93396,"ES":0.68571,"NES":0.96309,"nMoreExtreme":36133,"size":30,"leadingEdge":["ASCL2","STAP1","DUSP10","LIN28A","PTN"]} {"pathway":"GO_ACTIVATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY","pval":0.6522,"padj":0.94878,"ES":0.75987,"NES":0.96289,"nMoreExtreme":37984,"size":13,"leadingEdge":["RIPK2","BAK1","BAD"]} {"pathway":"GO_HISTONE_DEUBIQUITINATION","pval":0.57681,"padj":0.94161,"ES":0.71899,"NES":0.96259,"nMoreExtreme":36091,"size":22,"leadingEdge":["EPOP","ATXN7","USP15"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS","pval":0.54663,"padj":0.93112,"ES":0.63884,"NES":0.96257,"nMoreExtreme":38152,"size":47,"leadingEdge":["LAMP3","PANO1"]} {"pathway":"GO_GLOMERULAR_EPITHELIUM_DEVELOPMENT","pval":0.62237,"padj":0.94878,"ES":0.74926,"NES":0.96254,"nMoreExtreme":37281,"size":16,"leadingEdge":["MYO1E","PODXL","FOXC1","PROM1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY","pval":0.63262,"padj":0.94878,"ES":0.75331,"NES":0.96245,"nMoreExtreme":37591,"size":15,"leadingEdge":["MIR503","GATA3","SHISA2","FUZ"]} {"pathway":"GO_SYNAPTIC_MEMBRANE_ADHESION","pval":0.59544,"padj":0.94465,"ES":0.73364,"NES":0.962,"nMoreExtreme":36570,"size":19,"leadingEdge":["MDGA1","NTNG2","GPC4"]} {"pathway":"GO_EPIBOLY","pval":0.55876,"padj":0.93517,"ES":0.68799,"NES":0.96119,"nMoreExtreme":36259,"size":29,"leadingEdge":["CEACAM1","CD44"]} {"pathway":"GO_GENITALIA_MORPHOGENESIS","pval":0.6748,"padj":0.94976,"ES":0.75885,"NES":0.96094,"nMoreExtreme":38530,"size":11,"leadingEdge":["TIFAB","FGF10","NEUROG1","SYCP2"]} {"pathway":"GO_FAT_SOLUBLE_VITAMIN_METABOLIC_PROCESS","pval":0.56246,"padj":0.93517,"ES":0.69551,"NES":0.96071,"nMoreExtreme":36165,"size":27,"leadingEdge":["CYP1A1","TNF","CBR1","CYP27B1","ALDH1A2","CYP26B1"]} {"pathway":"GO_PROTEIN_KINASE_A_SIGNALING","pval":0.57892,"padj":0.94163,"ES":0.71751,"NES":0.96061,"nMoreExtreme":36223,"size":22,"leadingEdge":["LRRK2","AKAP7","AKAP12","TCIM","LCP1"]} {"pathway":"GO_MESONEPHROS_DEVELOPMENT","pval":0.5544,"padj":0.93396,"ES":0.59432,"NES":0.96053,"nMoreExtreme":42285,"size":83,"leadingEdge":["AGT","FGF10","SOX8","TGFB1","FOXC1","GATA3","SMAD3","SLIT2","HOXD11","WNT1","HNF1B","SIX1"]} {"pathway":"GO_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR_VIA_NONHOMOLOGOUS_END_JOINING","pval":0.5797,"padj":0.94163,"ES":0.71717,"NES":0.96015,"nMoreExtreme":36272,"size":22,"leadingEdge":["DTX3L","PARP3","PARP9","RIF1"]} {"pathway":"GO_PEPTIDE_HORMONE_SECRETION","pval":0.57628,"padj":0.94161,"ES":0.55675,"NES":0.95968,"nMoreExtreme":49219,"size":172,"leadingEdge":["CD38","JAK2","SIDT2","SRI","EDN1","IL1RN","EXOC3L1","CCL5","GLUL","IL6","TNF","VGF","SMPD3","MAFA","UCP2","NADK","ILDR1","CPT1A","PIM3"]} {"pathway":"GO_ZYGOTIC_DETERMINATION_OF_ANTERIOR_POSTERIOR_AXIS_EMBRYO","pval":0.62577,"padj":0.94878,"ES":0.69747,"NES":0.95942,"nMoreExtreme":33111,"size":5,"leadingEdge":["TIFAB","NEUROG1"]} {"pathway":"GO_RESPONSE_TO_INSULIN","pval":0.58689,"padj":0.94167,"ES":0.54834,"NES":0.95919,"nMoreExtreme":51757,"size":216,"leadingEdge":["SOCS1","CEACAM1","TNFSF10","EGR2","STAT1","AGT","ICAM1","CISH","LYN","VGF","TRIM72","SOCS3","SH2B2","PTPN2","PAK1","GCLC","SRC","UCP2","ATP6V1A","PTPN1","RHOQ","SORT1","CFLAR"]} {"pathway":"GO_PEPTIDYL_THREONINE_MODIFICATION","pval":0.56181,"padj":0.93517,"ES":0.57772,"NES":0.95914,"nMoreExtreme":44748,"size":108,"leadingEdge":["LRRK2","LMTK2","RIPK2","CAMK2D","VRK2","CHI3L1","TGFB1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II","pval":0.68373,"padj":0.94976,"ES":0.52432,"NES":0.95865,"nMoreExtreme":67943,"size":929,"leadingEdge":["IRF1","ASCL2","CD40","CIITA","CXCL10","NOD2","HGF","NLRC5","EGR2","ATF3","STAT1","RIPK2","ONECUT2","OVOL1","KLF4","MUC1","ARNTL2","FLT3LG","ZC3H12A","EBF4","ATF5","IRF7","EDN1","SBNO2","MAFF","BACH1","RELB","LITAF","NR4A3","TFEC","PLSCR1","IRF4","IL6","TLR3","FGF10","RFX5","EGR3","TBX19","NFKB2","TNF","SOX8","HELZ2","HNF4G","NCOA1","ASCL1","DDX58","NR1H3","NR4A2","AUTS2","LILRB1","KLF6","MAFA","STAT3","MACC1","RUNX1","TGFB1","STAT4","AKIRIN2","NAMPT","RHOQ","NFKBIA","RGMA","EGR4","CREBRF","IKZF4","HOXD8","IRF5","CX3CL1","FOXC1","GATA3","ERLIN1","PCGF5","NKX3-1","IRF2","NFE2L2","IL33","PPARGC1B"]} {"pathway":"GO_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORT","pval":0.55459,"padj":0.93396,"ES":0.60584,"NES":0.95864,"nMoreExtreme":41048,"size":69,"leadingEdge":["APOL1","SLC37A1","SLC12A3","CLIC5","SLC12A7","SLC26A11","PTAFR","CLCN4","GABRR2","ADAMTS8","CLIC2","SLC25A30"]} {"pathway":"GO_VIRION_ATTACHMENT_TO_HOST_CELL","pval":0.68694,"padj":0.94995,"ES":0.74264,"NES":0.95853,"nMoreExtreme":37850,"size":8,"leadingEdge":["ICAM1","GAS6","CD209"]} {"pathway":"GO_REGULATION_OF_RESPONSE_TO_DRUG","pval":0.5563,"padj":0.93517,"ES":0.61413,"NES":0.95771,"nMoreExtreme":40429,"size":61,"leadingEdge":["LRRK2","HGF","AGT","DTNBP1","NR4A3","TXN","NCOA1","CXCL12","SYT5","NFE2L2","SYT17","MET","ADORA2A"]} {"pathway":"GO_ORGANIC_HYDROXY_COMPOUND_BIOSYNTHETIC_PROCESS","pval":0.58719,"padj":0.94167,"ES":0.55001,"NES":0.95755,"nMoreExtreme":51210,"size":199,"leadingEdge":["GCH1","PLEK","HSD3B7","OSBPL6","RAPGEF2","CTNS","EPHX1","TNF","CH25H","CYP27B1","PTAFR","NR4A2","CES1","GATA3","ERLIN1","PLCB1","INSIG2","CD244","PROX1"]} {"pathway":"GO_MUSCLE_STRUCTURE_DEVELOPMENT","pval":0.63977,"padj":0.94878,"ES":0.52881,"NES":0.95752,"nMoreExtreme":61743,"size":497,"leadingEdge":["VAMP5","CXCL10","CXCL9","EGR2","ATF3","AGT","PIM1","ITGA7","MYOF","BHLHE41","FLT3LG","SRI","EDN1","ANK2","MAFF","COMP","DYSF","ASB2","MRAS","TIFAB","SOD2","MYH7","STAC3","FGF10","PLEKHO1","EGR3","TNF","SOX8","SLC8A1","TRIM72","IGSF8","PAK1","TGFB1","PDGFRA","SORT1","ACTN2","ADGRB1","RIPOR2","FOXC1","CFLAR","CD53","PLCB1","PDGFB","SMAD3","NUPR1","SIK1","MYOZ1","FOXN2","ZBTB42","BOC","PAX5","HLX","ARID5B","FLOT1","HEG1","ASS1","NFATC1","EREG","TBX1","PROX1","MAPK11","NEUROG1","WNT1","BTG2","PRICKLE1","HDAC4"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_ORGANELLE","pval":0.67875,"padj":0.94976,"ES":0.52416,"NES":0.95747,"nMoreExtreme":67277,"size":832,"leadingEdge":["GBP2","GBP5","GBP1","LRRK2","SNX10","OPTN","AGT","BCL2L11","PML","ZC3H12A","ACOT4","SCG3","DTX3L","PMAIP1","ANK2","GSTK1","KPNA5","PYHIN1","PARP3","PARP9","TNFAIP3","LILRB4","TXN","STAT3","SRC","TGFB1","SNX16","TXNIP","PTGS2","PARL","CNTLN","ANKRD13A","BBC3","SMAD3","GAS8"]} {"pathway":"GO_SYNAPTIC_SIGNALING","pval":0.64069,"padj":0.94878,"ES":0.52856,"NES":0.95737,"nMoreExtreme":61885,"size":504,"leadingEdge":["P2RX7","LRRK2","CD38","STX11","EGR2","GRIN3A","KCNJ10","JAK2","AGT","ERC2","GRM8","PRRT2","RASGRF1","P2RX4","RAPGEF2","MCTP2","EDN1","FAM107A","COLQ","NAAA","DTNBP1","GLUL","CADPS2","AKAP7","STAC3","JPH4","EGR3","TNF","SLC12A7","CCL2","KMO","STAT3","TRIM9","SRC","NTNG2","SYT5","AKAP12","GUCY1A1","GABRR2","ADGRB1","PTGS2","CX3CL1","GUCY1B1","PLCB1","GLS","SLC8A2","NAPA","STX3","SYT17","RNF19A","NGF","SHISA7","FLOT1","ARC","RAPSN","MAPK8IP2","KCNMB1"]} {"pathway":"GO_REGULATION_OF_ANION_TRANSPORT","pval":0.55735,"padj":0.93517,"ES":0.60688,"NES":0.95735,"nMoreExtreme":41110,"size":67,"leadingEdge":["P2RX7","AGT","ABCB1","P2RX4","EDN1","PTAFR","KMO","PRELID1"]} {"pathway":"GO_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION","pval":0.58933,"padj":0.94172,"ES":0.72013,"NES":0.95733,"nMoreExtreme":36677,"size":21,"leadingEdge":["AGT","CSF1","NR1H3","NFKBIA","PRKCH"]} {"pathway":"GO_POSITIVE_REGULATION_OF_BIOSYNTHETIC_PROCESS","pval":0.74309,"padj":0.95954,"ES":0.52224,"NES":0.95703,"nMoreExtreme":74281,"size":1611,"leadingEdge":["IRF1","IL31RA","ASCL2","CD40","CD74","CIITA","LRRK2","CD38","IL15","TBX21","CXCL10","NOD2","HGF","NLRC5","EGR2","ATF3","PADI2","STAT1","JAK2","AGT","RIPK2","TLR8","ONECUT2","OVOL1","IL27","ICAM1","CASZ1","KLF4","MUC1","ARNTL2","SAMD4A","FLT3LG","CD80","SOAT1","PML","ZC3H12A","EBF4","P2RX4","ATF5","IRF7","EDN1","NCF1","DTX3L","SBNO2","MAFF","DGAT2","BACH1","RELB","LITAF","CCL5","PYHIN1","TLR7","NR4A3","NPM2","PARP9","TFEC","PLSCR1","IRF4","NFE2L3","IL6","TLR3","FGF10","RFX5","LTB","EGR3","TBX19","NFKB2","TNF","SOX8","EBI3","CD86","HELZ2","HNF4G","SMPD3","NCOA1","ASCL1","PTPRC","PTAFR","DDX58","NR1H3","NR4A2","AUTS2","LILRB1","FPR2","KLF6","CCL2","MAFA","STAT3","GUCA1A","PTPN2","MACC1","RUNX1","SRC","TGFB1","CCL19","STAT4","AKIRIN2","NAMPT","CDKN1C","STN1","RHOQ","NFKBIA","ACTN2","RGMA","EGR4","ADGRB1","CREBRF","PTGS2","HAS2","IKZF4","HOXD8","IRF5","CX3CL1","FOXC1","GATA3","ERLIN1","PCGF5","NKX3-1","IRF2","NFE2L2","IL33","PPARGC1B","LIN28A","PLCB1","PDGFB","SMAD3","RAB38"]} {"pathway":"GO_ORGANIC_HYDROXY_COMPOUND_TRANSPORT","pval":0.58035,"padj":0.94163,"ES":0.5595,"NES":0.95625,"nMoreExtreme":48740,"size":153,"leadingEdge":["CEACAM1","AGT","OSBPL6","SOAT1","GRAMD1B","TTC39B","SLC18A1","DTNBP1","SLC2A13","SLC51A","NCOA1","CXCL12","LIPG","NR1H3","LILRB1","P2RY12","SYT5","SLC22A1","NFKBIA","GPM6B","CES1","SYT17","FCER1G"]} {"pathway":"GO_DNA_METHYLATION_ON_CYTOSINE","pval":0.51174,"padj":0.92419,"ES":0.64899,"NES":0.95615,"nMoreExtreme":26160,"size":3,"leadingEdge":["DNMT3B","DNMT3A","DNMT1"]} {"pathway":"GO_ORGANELLE_DISASSEMBLY","pval":0.56453,"padj":0.93517,"ES":0.58521,"NES":0.95587,"nMoreExtreme":43756,"size":92,"leadingEdge":["ATP13A2","OPTN","ATG3","SPAST"]} {"pathway":"GO_HARD_PALATE_DEVELOPMENT","pval":0.66253,"padj":0.94905,"ES":0.71477,"NES":0.95577,"nMoreExtreme":35557,"size":6,"leadingEdge":["MMP25","DLG1"]} {"pathway":"GO_TUMOR_NECROSIS_FACTOR_SECRETION","pval":0.60277,"padj":0.94684,"ES":0.72882,"NES":0.95568,"nMoreExtreme":37020,"size":19,"leadingEdge":["LRRK2","ZC3H12A","IFIH1","LILRA2","DDX58","CX3CL1","LILRA5","ORM1"]} {"pathway":"GO_SULFUR_COMPOUND_METABOLIC_PROCESS","pval":0.58447,"padj":0.94167,"ES":0.55677,"NES":0.95566,"nMoreExtreme":49503,"size":162,"leadingEdge":["SQOR","ACOT4","SULT1C2","GSTK1","DGAT2","CTNS","GGT5","STAT5A","HS3ST3B1","CHST2","ACSM5","ACPP","MTHFR","CBSL"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY","pval":0.59756,"padj":0.94558,"ES":0.72374,"NES":0.95549,"nMoreExtreme":36937,"size":20,"leadingEdge":["RSAD2","TICAM2","TLR3","NR1H3","WDFY1","TREML4","FLOT1","TLR1"]} {"pathway":"GO_ORGANOPHOSPHATE_CATABOLIC_PROCESS","pval":0.56983,"padj":0.93919,"ES":0.57699,"NES":0.95532,"nMoreExtreme":45196,"size":105,"leadingEdge":["PDE4B","ENPP2","PLA2G4C","PLA2G4A","SMPD3","LIPG","GPD2","ENTPD2"]} {"pathway":"GO_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS","pval":0.68157,"padj":0.94976,"ES":0.5232,"NES":0.95521,"nMoreExtreme":67449,"size":782,"leadingEdge":["LRRK2","IL15","GK","HGF","PIM1","GIMAP7","ACSL1","TYMP","MUC1","VPS9D1","SOAT1","JAK3","ACOT4","NPR1","SULT1C2","TMTC1","GTPBP1","DGAT2","SDC3","CTNS","GCNT3","CMPK2","DSE","EDEM1","MYH7","B4GALT5","CHST11","HS3ST3B1","PFKP","SMPD3","ACSL5","SLC25A25","ST3GAL5","ELOVL7","TMTC2","STAT3","TGFB1","ACSS1","CCL19","GALNT12","ATP6V1A","ADA2","NAGK","GM2A","ST6GALNAC2","GUCY1A1","RHOQ","CHST2","HAS2","GPD2","ACSM5","FOXC1","ACPP","GUCY1B1","FUT4","HS3ST3A1","AK4","PLCB1","NADK","PDGFB","LMF1"]} {"pathway":"GO_CELL_DIFFERENTIATION_INVOLVED_IN_METANEPHROS_DEVELOPMENT","pval":0.60354,"padj":0.94684,"ES":0.72831,"NES":0.95502,"nMoreExtreme":37067,"size":19,"leadingEdge":["STAT1","PDGFB","WWTR1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELL_PROJECTION_ORGANIZATION","pval":0.58466,"padj":0.94167,"ES":0.55725,"NES":0.95491,"nMoreExtreme":49378,"size":158,"leadingEdge":["LRRK2","CD38","KREMEN1","B2M","RAPGEF2","STAP1","CTSZ","SEMA7A","NTN1","SEMA4A","MAP2","RGMA","LPAR1","SEMA4D","DENND5A","SLIT2","TRIM46","RUFY3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NITRIC_OXIDE_BIOSYNTHETIC_PROCESS","pval":0.5637,"padj":0.93517,"ES":0.66921,"NES":0.95483,"nMoreExtreme":37262,"size":33,"leadingEdge":["JAK2","AGT","ICAM1","KLF4","P2RX4","EDN1","TNF","PTGS2","SMAD3","TLR4","ASS1","TICAM1"]} {"pathway":"GO_NEURON_DEVELOPMENT","pval":0.69629,"padj":0.94995,"ES":0.52233,"NES":0.95466,"nMoreExtreme":69137,"size":903,"leadingEdge":["LRRK2","CD38","HGF","KREMEN1","EGR2","GRIN3A","JAK2","AGT","ONECUT2","GLDN","SPTBN4","KLF4","SCARF1","B2M","C3","RASGRF1","RAPGEF2","ATF5","NRK","C21orf91","LYN","DTNBP1","NR4A3","NYAP2","NRCAM","RND1","B4GALT5","CTSZ","IL6","SEMA7A","DGKG","CAMK1D","MOV10","FARP2","ASCL1","UNC5C","NTN1","CXCL12","SLC4A10","NR4A2","AUTS2","PAK1","RUNX1","SRC","VAX2","SEMA4A","NTNG2","ROBO1","STMN3","STMND1","CDKN1C","ISL2","MAP2","RGMA","ADGRB1","LPAR1","GPM6B","CX3CL1","CFLAR","EPHA10","GATA3","NFE2L2","SRCIN1","SEMA4D","STX3","SYT17","DENND5A","PDZD7","SPTA1","SLIT2","RORB","BOC","TRIM46","NGF","C9orf72","FLOT1","ARC","MAPK8IP2","RUFY3","PLPPR4","COBL","MCF2","ADORA2A","LIMK1","PTN","LZTS1","NPTX1","SEMA3F","BTG2"]} {"pathway":"GO_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS","pval":0.65284,"padj":0.94878,"ES":0.52648,"NES":0.9546,"nMoreExtreme":63253,"size":526,"leadingEdge":["IDO1","CD74","GCH1","PDE4B","CEACAM1","PLEK","ATF3","TYMP","CYP1A1","HSD3B7","OSBPL6","EDN1","DHRS9","DGAT2","GGT5","GLUL","EPHX1","KYNU","TNF","CBR1","CH25H","PLA2G4A","CYP27B1","PTAFR","NR1H3","ELOVL7","KMO","PTPN2","ACSS1","ADA2","MMAA","PTGS2","GPD2","ACSM5","ASNS","CES1","ERLIN1","PLCB1","GLS","SIK1","RFK","SEPHS2","INSIG2","ENTPD2","ASS1","MTHFR","CBSL","ALDH1A2","CD244","SDS","LPGAT1","PROX1"]} {"pathway":"GO_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION","pval":0.55989,"padj":0.93517,"ES":0.64676,"NES":0.95432,"nMoreExtreme":38265,"size":41,"leadingEdge":["ENPP2","AUTS2","SRC","SLIT2","WNT1","HDAC4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION","pval":0.56081,"padj":0.93517,"ES":0.62486,"NES":0.95421,"nMoreExtreme":39702,"size":52,"leadingEdge":["CD40","P2RX4","VEGFC","STAT5A","TGFB1","PTGS2","NFE2L2","PDGFB"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS","pval":0.56277,"padj":0.93517,"ES":0.66244,"NES":0.95412,"nMoreExtreme":37509,"size":35,"leadingEdge":["PLEK","SMPD3","STAT3","TGFB1","SIK1","HDAC4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ANION_TRANSPORT","pval":0.56242,"padj":0.93517,"ES":0.6591,"NES":0.95357,"nMoreExtreme":37675,"size":36,"leadingEdge":["P2RX7","AGT","ABCB1","P2RX4","EDN1","PTAFR","KMO","PRELID1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_T_CELL_DIFFERENTIATION_IN_THYMUS","pval":0.66341,"padj":0.94905,"ES":0.71306,"NES":0.95349,"nMoreExtreme":35604,"size":6,"leadingEdge":["PTPN2","TMEM131L"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TRANSPORTER_ACTIVITY","pval":0.56692,"padj":0.93607,"ES":0.59147,"NES":0.9534,"nMoreExtreme":43072,"size":81,"leadingEdge":["ATP1B2","ABCB1","CTSS","ANK2","SYNGR3","RNF207","STAC3","PTAFR","ACTN2","RGS9","GLRX","S100A1","ARC","HAP1"]} {"pathway":"GO_PHAGOSOME_MATURATION","pval":0.56208,"padj":0.93517,"ES":0.64817,"NES":0.95323,"nMoreExtreme":38313,"size":40,"leadingEdge":["P2RX7","RAB20","SLAMF8","ATP6V1A","RAB38","RAB39A","RAB43"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PRODUCTION_OF_MIRNAS_INVOLVED_IN_GENE_SILENCING_BY_MIRNA","pval":0.68809,"padj":0.94995,"ES":0.75071,"NES":0.95305,"nMoreExtreme":38839,"size":10,"leadingEdge":["TGFB1","LIN28A","DDX5"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_RNA_BIOSYNTHETIC_PROCESS","pval":0.71342,"padj":0.9532,"ES":0.52092,"NES":0.95303,"nMoreExtreme":71006,"size":1004,"leadingEdge":["IRF1","ASCL2","CIITA","ETV7","CD38","TBX21","ATF3","STAT1","IFI27","OVOL1","BATF3","BHLHE41","KLF4","MUC1","TRIM22","PML","ZNFX1","ATF5","IRF7","EDN1","SBNO2","HSBP1L1","BACH1","RELB","BCL6","NR4A3","ZMYND15","PARP9","TFEC","NFE2L3","LILRB4","TXN","RFX5","TNF","SOX8","FST","ASCL1","NR1H3","NR4A2","STAT3","PTPN2","TGIF2","GCLC","RUNX1","SRC","TGFB1","VAX2","AKIRIN2","TXNIP","CDKN1C","CREG1","IKZF4","HOXD8","GAS6","ARID5A","FOXC1","GATA3","NKX3-1","IRF2","PPARGC1B","CIR1","SEMA4D","PLCB1","PDGFB","SMAD3","ZFP36","MYOZ1","RORB","ZBTB42","PAX5","BCL6B","CDYL2","S100A1","ARID5B","HIC1","IRF8"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELL_DEVELOPMENT","pval":0.61474,"padj":0.94747,"ES":0.53859,"NES":0.95303,"nMoreExtreme":55785,"size":268,"leadingEdge":["ASCL2","GBP1","LRRK2","CD38","KREMEN1","B2M","RAPGEF2","STAP1","DYNLT1","CTSZ","IL6","SEMA7A","TNF","SOX8","DUSP10","ASCL1","NTN1","LILRB1","STAT3","PAK1","TGFB1","SEMA4A","ISL2","MAP2","RGMA","LPAR1","CX3CL1","AP1AR","LIN28A","SEMA4D","DENND5A","SLIT2","TRIM46"]} {"pathway":"GO_MIDDLE_EAR_MORPHOGENESIS","pval":0.63207,"padj":0.94878,"ES":0.74174,"NES":0.95289,"nMoreExtreme":37862,"size":16,"leadingEdge":["EDN1","INSIG2","TBX1","SIX1"]} {"pathway":"GO_REGULATION_OF_MEMBRANE_POTENTIAL","pval":0.61907,"padj":0.94878,"ES":0.53614,"NES":0.95288,"nMoreExtreme":56794,"size":294,"leadingEdge":["ATP1B2","P2RX7","LRRK2","GRIN3A","KCNJ10","KCNJ2","CAMK2D","SRI","P2RX4","EDN1","PMAIP1","ANK2","CTNS","KCNE5","NRCAM","RNF207","SLC8A1","SCN9A","RGS7BP","KCNE1","CACNA1I","GCLC","SRC","KCNMA1","SNX16","UCP2","ACTN2","GABRR2","IFI6","PRELID1","GLRX","KCNE1B","BAK1"]} {"pathway":"GO_SENSORY_PERCEPTION_OF_SWEET_TASTE","pval":0.49852,"padj":0.91907,"ES":0.63885,"NES":0.95288,"nMoreExtreme":25051,"size":2,"leadingEdge":["ITPR3","REEP2"]} {"pathway":"GO_PROTEIN_TARGETING_TO_MITOCHONDRION","pval":0.5722,"padj":0.94008,"ES":0.58017,"NES":0.95282,"nMoreExtreme":44723,"size":97,"leadingEdge":["LRRK2","PARL","AGK"]} {"pathway":"GO_FATTY_ACID_DERIVATIVE_METABOLIC_PROCESS","pval":0.68362,"padj":0.94976,"ES":0.7284,"NES":0.9528,"nMoreExtreme":37158,"size":7,"leadingEdge":["DGAT2","FAR2"]} {"pathway":"GO_REGULATION_OF_T_CELL_MIGRATION","pval":0.56465,"padj":0.93517,"ES":0.66149,"NES":0.95275,"nMoreExtreme":37634,"size":35,"leadingEdge":["CXCL10","CCL5","TNFRSF14","CXCL12","CCR6","RIPOR2"]} {"pathway":"GO_REGULATION_OF_MONOOXYGENASE_ACTIVITY","pval":0.5624,"padj":0.93517,"ES":0.63628,"NES":0.95262,"nMoreExtreme":39045,"size":45,"leadingEdge":["GCH1","TNF","CYP27B1","MIR212","S100A1"]} {"pathway":"GO_REGULATION_OF_FC_RECEPTOR_MEDIATED_STIMULATORY_SIGNALING_PATHWAY","pval":0.68145,"padj":0.94976,"ES":0.75186,"NES":0.95209,"nMoreExtreme":38910,"size":11,"leadingEdge":["LYN","PLSCR1","CD226","CD47","PTPRC"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT","pval":0.56484,"padj":0.93517,"ES":0.61577,"NES":0.95172,"nMoreExtreme":40524,"size":57,"leadingEdge":["ZC3H12A","TGFB1","PTGS2","GAS6","SMAD3","CDH1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MACROPHAGE_MIGRATION","pval":0.64337,"padj":0.94878,"ES":0.74482,"NES":0.95161,"nMoreExtreme":38230,"size":15,"leadingEdge":["P2RX4","CCL5","CSF1","P2RY12","CCL3"]} {"pathway":"GO_CELLULAR_EXTRAVASATION","pval":0.56361,"padj":0.93517,"ES":0.62798,"NES":0.95149,"nMoreExtreme":39547,"size":49,"leadingEdge":["SELL","VCAM1","ICAM1","PTGER4","TNF","CD47","CXCL12","PTAFR","CCL2","ITGB7","RIPOR2","CX3CL1","PLCB1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELL_AGING","pval":0.67197,"padj":0.94905,"ES":0.75136,"NES":0.95146,"nMoreExtreme":38760,"size":12,"leadingEdge":["HLA-G","CGAS","ARG2"]} {"pathway":"GO_EXCITATORY_CHEMICAL_SYNAPTIC_TRANSMISSION","pval":0.51301,"padj":0.92459,"ES":0.64579,"NES":0.95143,"nMoreExtreme":26225,"size":3,"leadingEdge":["SSH1","GRIN2D","PDLIM4"]} {"pathway":"GO_REGULATION_OF_LYMPHOCYTE_MIGRATION","pval":0.56557,"padj":0.93517,"ES":0.62407,"NES":0.95093,"nMoreExtreme":39954,"size":51,"leadingEdge":["CXCL10","PADI2","CCL7","CCL5","TNFRSF14","CXCL12","CCL4","CCL2","CCR6","RIPOR2","CCL3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS","pval":0.68249,"padj":0.94976,"ES":0.75071,"NES":0.95063,"nMoreExtreme":38969,"size":11,"leadingEdge":["NR4A3","CPT1A"]} {"pathway":"GO_RENAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_BLOOD_VOLUME","pval":0.6929,"padj":0.94995,"ES":0.74369,"NES":0.94992,"nMoreExtreme":38721,"size":9,"leadingEdge":["GAS6","PDGFB","CYBA"]} {"pathway":"GO_REGULATION_OF_GLOMERULAR_FILTRATION","pval":0.6929,"padj":0.94995,"ES":0.74369,"NES":0.94992,"nMoreExtreme":38721,"size":9,"leadingEdge":["GAS6","PDGFB","CYBA"]} {"pathway":"GO_REGULATION_OF_SECONDARY_METABOLIC_PROCESS","pval":0.68343,"padj":0.94976,"ES":0.74964,"NES":0.94928,"nMoreExtreme":39023,"size":11,"leadingEdge":["RAPGEF2","CDH3"]} {"pathway":"GO_CELLULAR_MODIFIED_AMINO_ACID_METABOLIC_PROCESS","pval":0.5779,"padj":0.94163,"ES":0.68723,"NES":0.94927,"nMoreExtreme":37158,"size":27,"leadingEdge":["HPN","GATA3","MRI1"]} {"pathway":"GO_FIBROBLAST_PROLIFERATION","pval":0.57326,"padj":0.94062,"ES":0.59364,"NES":0.94888,"nMoreExtreme":43046,"size":75,"leadingEdge":["CD74","AGT","PML","PARP10","LTA","FGF10","TGFB1","CDKN1A","PDGFRA","LIG4","GAS6","PDGFB","NUPR1","EREG","WNT1"]} {"pathway":"GO_RAC_PROTEIN_SIGNAL_TRANSDUCTION","pval":0.57316,"padj":0.94062,"ES":0.66491,"NES":0.94869,"nMoreExtreme":37887,"size":33,"leadingEdge":["RASGRF1","FARP2","AUTS2","STMN3","ALS2"]} {"pathway":"GO_ADHESION_OF_SYMBIONT_TO_HOST_CELL","pval":0.69358,"padj":0.94995,"ES":0.74263,"NES":0.94857,"nMoreExtreme":38759,"size":9,"leadingEdge":["ICAM1","GAS6","CD209"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ISOTYPE_SWITCHING_TO_IGG_ISOTYPES","pval":0.69173,"padj":0.94995,"ES":0.7348,"NES":0.94842,"nMoreExtreme":38114,"size":8,"leadingEdge":["CD40","TBX21","PTPRC"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II","pval":0.69517,"padj":0.94995,"ES":0.5202,"NES":0.94811,"nMoreExtreme":68451,"size":689,"leadingEdge":["ASCL2","CIITA","ETV7","TBX21","ATF3","STAT1","IFI27","OVOL1","BATF3","BHLHE41","KLF4","IRF7","EDN1","BACH1","RELB","BCL6","NR4A3","PARP9","NFE2L3","LILRB4","TXN","RFX5","TNF","FST","ASCL1","NR1H3","NR4A2","STAT3","PTPN2","TGIF2","RUNX1","TGFB1","VAX2","AKIRIN2","TXNIP","CDKN1C","HOXD8","ARID5A","FOXC1","GATA3","IRF2","SEMA4D","PDGFB","SMAD3","ZFP36","MYOZ1","ZBTB42","PAX5","BCL6B","S100A1","ARID5B","HIC1","IRF8"]} {"pathway":"GO_ORGANIC_ANION_TRANSPORT","pval":0.64011,"padj":0.94878,"ES":0.53036,"NES":0.94797,"nMoreExtreme":59628,"size":333,"leadingEdge":["SLC6A12","P2RX7","CEACAM1","SLC37A1","KCNJ10","AGT","ABCC11","ANO4","ACSL1","ABCB1","P2RX4","EDN1","CTNS","XKR6","PLSCR4","PLSCR1","SLC27A3","SLCO4A1","SLC51A","PLA2G4A","SLC25A22","NCOA1","XKR8","SLC25A25","SLC4A10","KMO","SLC7A2","GLTPD2","ABCC2","MFSD2A","XKR7","PRELID1","GLS","NFKBIE"]} {"pathway":"GO_MEMBRANE_DOCKING","pval":0.60492,"padj":0.94687,"ES":0.54974,"NES":0.94758,"nMoreExtreme":51665,"size":172,"leadingEdge":["PLEK","STX11","VCAM1","ICAM1","RALB","PSEN2","TUBA4A","STX3","STX17"]} {"pathway":"GO_RESPONSE_TO_DEXAMETHASONE","pval":0.57666,"padj":0.94161,"ES":0.66757,"NES":0.94744,"nMoreExtreme":37922,"size":32,"leadingEdge":["ICAM1","EDN1","PTAFR","TGFB1","CFLAR","ASS1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_NIK_NF_KAPPAB_SIGNALING","pval":0.62823,"padj":0.94878,"ES":0.7322,"NES":0.9469,"nMoreExtreme":37963,"size":17,"leadingEdge":["ZC3H12A","CYLD","LITAF","TSPAN6"]} {"pathway":"GO_METANEPHROS_DEVELOPMENT","pval":0.57554,"padj":0.94161,"ES":0.5991,"NES":0.94657,"nMoreExtreme":42527,"size":68,"leadingEdge":["STAT1","FGF10","SOX8","PDGFRA","GATA3","NKX3-1","PDGFB","HNF1B","SIX1"]} {"pathway":"GO_DETECTION_OF_MECHANICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION","pval":0.61407,"padj":0.94703,"ES":0.7216,"NES":0.94621,"nMoreExtreme":37714,"size":19,"leadingEdge":["HPN","CXCL12","PDZD7","FYN"]} {"pathway":"GO_AMYLOID_BETA_METABOLIC_PROCESS","pval":0.57468,"padj":0.94135,"ES":0.65094,"NES":0.94574,"nMoreExtreme":38658,"size":37,"leadingEdge":["GSAP","PSEN2","HAP1"]} {"pathway":"GO_POLYOL_BIOSYNTHETIC_PROCESS","pval":0.578,"padj":0.94163,"ES":0.60294,"NES":0.94559,"nMoreExtreme":42327,"size":64,"leadingEdge":["GCH1","PLEK","EPHX1","CYP27B1","PTAFR","PLCB1","CD244"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_HORMONE_STIMULUS","pval":0.67998,"padj":0.94976,"ES":0.52158,"NES":0.94545,"nMoreExtreme":65833,"size":520,"leadingEdge":["SOCS1","CEACAM1","RXFP1","ACOD1","SSTR2","PADI2","STAT1","JAK2","AGT","ACSL1","ICAM1","PAQR8","BCL2L11","CTSS","JAK3","EDN1","FAM107A","CISH","PTGER4","LYN","EPHX1","NR4A3","CTSL","PTGER2","STAT5A","TRIM72","HNF4G","NCOA1","NR1H3","NR4A2","SOCS3","SH2B2","STAT3","PTPN2","PAK1","GCLC","RUNX1","SRC","TGFB1","UCP2","ATP6V1A","PTPN1","RHOQ","ACTN2","CREBRF","PLPP1","GPR150","ASNS","CFLAR","AGTRAP","NKX3-1","NFE2L2","PPARGC1B","PLCB1","ZFP36","SLIT2","RORB","NCOA4","ESRRB"]} {"pathway":"GO_ATRIAL_CARDIAC_MUSCLE_CELL_TO_AV_NODE_CELL_SIGNALING","pval":0.63,"padj":0.94878,"ES":0.73106,"NES":0.94542,"nMoreExtreme":38070,"size":17,"leadingEdge":["ANK2","KCNE5","RNF207","KCNQ1"]} {"pathway":"GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_CIRCULATORY_RENIN_ANGIOTENSIN","pval":0.66786,"padj":0.94905,"ES":0.74595,"NES":0.94525,"nMoreExtreme":38896,"size":13,"leadingEdge":["SUCNR1","CTSZ","CES1","ENPEP"]} {"pathway":"GO_CATECHOLAMINE_UPTAKE","pval":0.69287,"padj":0.94995,"ES":0.74439,"NES":0.94503,"nMoreExtreme":39109,"size":10,"leadingEdge":["SLC22A1","DRD4"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ACTIVIN_RECEPTOR_SIGNALING_PATHWAY","pval":0.68703,"padj":0.94995,"ES":0.7222,"NES":0.94469,"nMoreExtreme":37343,"size":7,"leadingEdge":["FST","FSTL3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_OSSIFICATION","pval":0.5767,"padj":0.94161,"ES":0.61117,"NES":0.9446,"nMoreExtreme":41375,"size":57,"leadingEdge":["KREMEN1","CHRD","TNF","TGFB1","CCL3","SEMA4D","SMAD3","RORB","CCR1","HDAC4"]} {"pathway":"GO_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL","pval":0.57695,"padj":0.94161,"ES":0.61268,"NES":0.94454,"nMoreExtreme":41275,"size":56,"leadingEdge":["KCNJ2","CAMK2D","ANK2","KCNE5","RNF207","SLC8A1","KCNE1","KCNE1B"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY","pval":0.58718,"padj":0.94167,"ES":0.57885,"NES":0.9442,"nMoreExtreme":45396,"size":91,"leadingEdge":["CHRD","ONECUT2","HTRA4","CHST11","FST","TGFB1","SMAD3","WNT1","EID2"]} {"pathway":"GO_PLATELET_ACTIVATION","pval":0.59819,"padj":0.94558,"ES":0.56132,"NES":0.94404,"nMoreExtreme":48733,"size":125,"leadingEdge":["CD40","CEACAM1","PLEK","TSPAN32","COMP","LYN","PLSCR1","IL6","DGKG","F2RL2","LCP2","P2RY12","SRC","GP1BA","PDGFRA","GAS6","PDGFB","FCER1G","TLR4","ENTPD2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CHROMATIN_ORGANIZATION","pval":0.58774,"padj":0.94167,"ES":0.58072,"NES":0.94396,"nMoreExtreme":45203,"size":88,"leadingEdge":["LRRK2","MUC1","BCL6","AUTS2","TGFB1","GATA3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS","pval":0.59485,"padj":0.94458,"ES":0.69525,"NES":0.94294,"nMoreExtreme":37672,"size":24,"leadingEdge":["LAG3","NMI","KLF4","IL6","PTPRC","LILRB1","ZFP36"]} {"pathway":"GO_PROTEIN_POLY_ADP_RIBOSYLATION","pval":0.6876,"padj":0.94995,"ES":0.72076,"NES":0.94281,"nMoreExtreme":37374,"size":7,"leadingEdge":["PARP10","PARP3","PARP15"]} {"pathway":"GO_ADHESION_OF_SYMBIONT_TO_HOST","pval":0.69438,"padj":0.94995,"ES":0.74263,"NES":0.9428,"nMoreExtreme":39194,"size":10,"leadingEdge":["ICAM1","GAS6","SCARB1"]} {"pathway":"GO_GAMMA_DELTA_T_CELL_ACTIVATION","pval":0.66064,"padj":0.94905,"ES":0.74036,"NES":0.94218,"nMoreExtreme":38885,"size":14,"leadingEdge":["NOD2","EGR3","GPR18","PTPRC","LILRB1","MICB"]} {"pathway":"GO_FOLIC_ACID_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS","pval":0.69718,"padj":0.94995,"ES":0.73732,"NES":0.94178,"nMoreExtreme":38960,"size":9,"leadingEdge":["GCH1","MTHFD1"]} {"pathway":"GO_MORPHOGENESIS_OF_AN_EPITHELIAL_SHEET","pval":0.58047,"padj":0.94163,"ES":0.61991,"NES":0.94174,"nMoreExtreme":40829,"size":50,"leadingEdge":["CEACAM1","LAMA1","DVL2"]} {"pathway":"GO_HORMONE_TRANSPORT","pval":0.63115,"padj":0.94878,"ES":0.53733,"NES":0.94163,"nMoreExtreme":55898,"size":223,"leadingEdge":["CD38","HCAR2","JAK2","AGT","SIDT2","SRI","EDN1","IL1RN","EXOC3L1","CCL5","LYN","GLUL","SLCO4A1","IL6","TNF","VGF","SMPD3","MAFA","SLC22A1","UCP2","GATA3","NKX3-1","NADK","ILDR1"]} {"pathway":"GO_REGULATION_OF_PROTEIN_TARGETING_TO_MEMBRANE","pval":0.58598,"padj":0.94167,"ES":0.66302,"NES":0.94098,"nMoreExtreme":38535,"size":32,"leadingEdge":["KCNE1","PAK1","STOM","FYN"]} {"pathway":"GO_EXTRACELLULAR_MATRIX_ASSEMBLY","pval":0.60108,"padj":0.94649,"ES":0.69806,"NES":0.94069,"nMoreExtreme":37818,"size":23,"leadingEdge":["AGT","SMPD3","TGFB1","GPM6B","HAS2","GAS6","SMAD3"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_CILIUM","pval":0.58048,"padj":0.94163,"ES":0.63753,"NES":0.94069,"nMoreExtreme":39672,"size":41,"leadingEdge":["SNX10","GAS8","EHD1"]} {"pathway":"GO_ALCOHOL_BIOSYNTHETIC_PROCESS","pval":0.61227,"padj":0.94703,"ES":0.55302,"NES":0.9402,"nMoreExtreme":50893,"size":143,"leadingEdge":["GCH1","PLEK","EPHX1","TNF","CYP27B1","PTAFR","CES1","ERLIN1","PLCB1","INSIG2","CD244"]} {"pathway":"GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS","pval":0.59849,"padj":0.94558,"ES":0.57115,"NES":0.93999,"nMoreExtreme":46951,"size":99,"leadingEdge":["ZC3H12A","DTX3L","PYHIN1","PARP9","LILRB4","SRC","TGFB1","PTGS2","SMAD3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_CELL_DEATH","pval":0.67224,"padj":0.94905,"ES":0.74175,"NES":0.93992,"nMoreExtreme":39151,"size":13,"leadingEdge":["MCL1","TLR4","HDAC6"]} {"pathway":"GO_3_PHOSPHOADENOSINE_5_PHOSPHOSULFATE_METABOLIC_PROCESS","pval":0.66288,"padj":0.94905,"ES":0.73825,"NES":0.93949,"nMoreExtreme":39017,"size":14,"leadingEdge":["SULT1C2","IMPAD1"]} {"pathway":"GO_CELL_COMMUNICATION_INVOLVED_IN_CARDIAC_CONDUCTION","pval":0.58345,"padj":0.94167,"ES":0.62731,"NES":0.93919,"nMoreExtreme":40506,"size":45,"leadingEdge":["ATP1B2","CAMK2D","SRI","GJD3","ANK2","KCNE5","RNF207","SLC8A1"]} {"pathway":"GO_EPITHELIAL_CELL_PROLIFERATION","pval":0.65667,"padj":0.94878,"ES":0.52767,"NES":0.93889,"nMoreExtreme":60411,"size":301,"leadingEdge":["NOD2","CEACAM1","HGF","STAT1","SIDT2","VEGFC","MIR503","DYSF","GLUL","NR4A3","PRKX","TNFAIP3","FGF10","EGR3","TNF","STAT5A","FLT1","HPN","DUSP10","CXCL12","F3","CCL2","STAT3","TGFB1","ROBO1","CDKN1C","HAS2","CFLAR","GATA3","NKX3-1","PDGFB","SMAD3","ZFP36","COL8A2","PPP1R16B","ALDH1A2","EREG","TBX1","PROX1","SOX2","PTN"]} {"pathway":"GO_PTERIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS","pval":0.66367,"padj":0.94905,"ES":0.73732,"NES":0.93831,"nMoreExtreme":39063,"size":14,"leadingEdge":["GCH1","MTHFD1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION","pval":0.61333,"padj":0.94703,"ES":0.70579,"NES":0.93826,"nMoreExtreme":38171,"size":21,"leadingEdge":["MIR503","NFE2L2","SLIT2","MEF2C"]} {"pathway":"GO_ANIMAL_ORGAN_FORMATION","pval":0.58543,"padj":0.94167,"ES":0.6209,"NES":0.93822,"nMoreExtreme":40988,"size":48,"leadingEdge":["PIM1","FGF10","ROBO1","SMARCD3","SIX1","HOXA11"]} {"pathway":"GO_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION","pval":0.58644,"padj":0.94167,"ES":0.64559,"NES":0.93798,"nMoreExtreme":39449,"size":37,"leadingEdge":["MAFF","CTSL","CYP27B1","RUNX1","FOXC1","ZFP36","MYCL"]} {"pathway":"GO_REGULATION_OF_CELL_JUNCTION_ASSEMBLY","pval":0.59737,"padj":0.94558,"ES":0.5803,"NES":0.93787,"nMoreExtreme":45563,"size":83,"leadingEdge":["AGT","RAPGEF2","FAM107A","S100A10","TNF","RUNX1","SRC","GPM6B","SMAD3","FLOT1"]} {"pathway":"GO_METANEPHRIC_NEPHRON_MORPHOGENESIS","pval":0.61393,"padj":0.94703,"ES":0.70548,"NES":0.93786,"nMoreExtreme":38208,"size":21,"leadingEdge":["STAT1","SOX8","PKD1"]} {"pathway":"GO_REGULATION_OF_MITOCHONDRION_ORGANIZATION","pval":0.62508,"padj":0.94878,"ES":0.54608,"NES":0.93758,"nMoreExtreme":52978,"size":163,"leadingEdge":["LRRK2","HGF","TNFSF10","ATP13A2","OPTN","STAT2","BCL2L11","PMAIP1","PARL","PRELID1","BBC3","BAK1","DDHD1"]} {"pathway":"GO_REGULATION_OF_SUPRAMOLECULAR_FIBER_ORGANIZATION","pval":0.66189,"padj":0.94905,"ES":0.52644,"NES":0.93748,"nMoreExtreme":61048,"size":306,"leadingEdge":["PLEK","SPTBN4","ICAM1","SCIN","TMSB10","EDN1","S100A10","PTGER4","PPM1E","CD47","CXCL12","ACTR3C","PAK1","CDC42EP2","ACTN2","MAP2","LPAR1","CX3CL1","AP1AR","SMAD3","SPTA1","SLIT2","C9orf72","MET","PROX1","LIMK1"]} {"pathway":"GO_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_BETA_SIGNALING_PATHWAY","pval":0.66426,"padj":0.94905,"ES":0.73666,"NES":0.93747,"nMoreExtreme":39098,"size":14,"leadingEdge":["PTPN2","SRC","PTPN1","PDGFB","ABL1"]} {"pathway":"GO_ESTABLISHMENT_OF_ENDOTHELIAL_BARRIER","pval":0.58817,"padj":0.94167,"ES":0.65076,"NES":0.9373,"nMoreExtreme":39202,"size":35,"leadingEdge":["ICAM1","RAPGEF2","MARVELD2","TNF","PPP1R16B"]} {"pathway":"GO_MUSCLE_CELL_MIGRATION","pval":0.59463,"padj":0.94453,"ES":0.58636,"NES":0.93725,"nMoreExtreme":44650,"size":75,"leadingEdge":["AGT","MIR503","CCL5","NR4A3","PLEKHO1","PAK1","SRC","LPAR1","HAS2","NFE2L2","PDGFB","SLIT2","HDAC4","SIX1"]} {"pathway":"GO_CARBOHYDRATE_TRANSPORT","pval":0.60737,"padj":0.94703,"ES":0.56441,"NES":0.93704,"nMoreExtreme":48377,"size":108,"leadingEdge":["SLC37A1","TMEM144","C3","SLC2A6","SLC45A4","EDN1","NR4A3","RSC1A1","TNF","SMPD3","RHOQ","SORT1","MFSD2A","NFE2L2","EDNRA"]} {"pathway":"GO_RESPIRATORY_GASEOUS_EXCHANGE","pval":0.58779,"padj":0.94167,"ES":0.62764,"NES":0.93644,"nMoreExtreme":40667,"size":44,"leadingEdge":["ECEL1","CSF2RB","EDN1","CHST11","NR4A2","GLS","EDNRA"]} {"pathway":"GO_PEPTIDYL_TYROSINE_AUTOPHOSPHORYLATION","pval":0.59376,"padj":0.94378,"ES":0.66673,"NES":0.93642,"nMoreExtreme":38706,"size":30,"leadingEdge":["ITK","LYN","SRC","FGR"]} {"pathway":"GO_EXTRACELLULAR_STRUCTURE_ORGANIZATION","pval":0.67033,"padj":0.94905,"ES":0.52385,"NES":0.93634,"nMoreExtreme":62443,"size":333,"leadingEdge":["AGT","ITGA7","COL9A2","VCAM1","ICAM1","SOAT1","CTSS","ICAM2","COMP","COLQ","MMP25","CTSL","ICAM4","IL6","NFKB2","TNF","TEX14","HPN","CD47","SMPD3","ITGAL","LIPG","ITGB7","MYO1E","TGFB1","A2M","PDGFRA","CAPNS2","GPM6B","ADAMTS20","HAS2","GAS6","FOXC1","CFLAR","PDGFB","SMAD3","CRISPLD2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MEIOSIS_I","pval":0.59469,"padj":0.94453,"ES":0.7025,"NES":0.93633,"nMoreExtreme":29756,"size":1,"leadingEdge":["UBE2B"]} {"pathway":"GO_CELLULAR_MAGNESIUM_ION_HOMEOSTASIS","pval":0.5188,"padj":0.92533,"ES":0.63551,"NES":0.93629,"nMoreExtreme":26521,"size":3,"leadingEdge":["XK","TRPM7","SLC41A1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION","pval":0.60342,"padj":0.94684,"ES":0.57065,"NES":0.93626,"nMoreExtreme":47083,"size":96,"leadingEdge":["PSME2","PSMB9","PSME1","PSMB10","PSMB8","ATF5","CHMP4C","PSMA4","PSMA2","CUL1","MIIP","NBN","PSMA5"]} {"pathway":"GO_REGULATION_OF_LIPOPOLYSACCHARIDE_MEDIATED_SIGNALING_PATHWAY","pval":0.61,"padj":0.94703,"ES":0.69929,"NES":0.93622,"nMoreExtreme":38168,"size":22,"leadingEdge":["ACOD1","CARD16","LILRA2","TNFAIP3","CX3CL1"]} {"pathway":"GO_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY","pval":0.59862,"padj":0.94558,"ES":0.58151,"NES":0.93619,"nMoreExtreme":45426,"size":80,"leadingEdge":["AGT","STAP1","NCF1","MVP","CCL5","PTPRC","PTPN2","SRC","PTPN1","GAS6","SRCIN1","PDGFB","LILRA5","EREG"]} {"pathway":"GO_PHYSIOLOGICAL_CARDIAC_MUSCLE_HYPERTROPHY","pval":0.61026,"padj":0.94703,"ES":0.69919,"NES":0.93608,"nMoreExtreme":38184,"size":22,"leadingEdge":["AGT","EDN1","PAK1","IGF1"]} {"pathway":"GO_RESPONSE_TO_SODIUM_ARSENITE","pval":0.63032,"padj":0.94878,"ES":0.68025,"NES":0.93574,"nMoreExtreme":33352,"size":5,"leadingEdge":["ZC3H12A","HNRNPA1"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_SODIUM_ARSENITE","pval":0.63032,"padj":0.94878,"ES":0.68025,"NES":0.93574,"nMoreExtreme":33352,"size":5,"leadingEdge":["ZC3H12A","HNRNPA1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION","pval":0.60429,"padj":0.94684,"ES":0.6898,"NES":0.93555,"nMoreExtreme":38270,"size":24,"leadingEdge":["CHRD","STAT1","TBX1","SIX1"]} {"pathway":"GO_PROTEIN_HETEROOLIGOMERIZATION","pval":0.60014,"padj":0.94564,"ES":0.58101,"NES":0.93539,"nMoreExtreme":45541,"size":80,"leadingEdge":["CD74","GCH1","S100A10","BIRC3","IKZF4"]} {"pathway":"GO_CARDIAC_MUSCLE_CELL_MEMBRANE_REPOLARIZATION","pval":0.59584,"padj":0.94465,"ES":0.66566,"NES":0.93493,"nMoreExtreme":38842,"size":30,"leadingEdge":["KCNJ2","ANK2","KCNE5","RNF207","KCNE1","KCNE1B"]} {"pathway":"GO_BRANCHING_MORPHOGENESIS_OF_AN_EPITHELIAL_TUBE","pval":0.61966,"padj":0.94878,"ES":0.55398,"NES":0.93486,"nMoreExtreme":50776,"size":130,"leadingEdge":["AGT","PML","EDN1","CSF1","CTSZ","FGF10","TNF","SOX8","PAK1","SRC","TGFB1","NKX3-1","SLIT2","HOXD11","EDNRA","MET","WNT1","HNF1B","SEMA3E","LAMA1","SIX1"]} {"pathway":"GO_CELL_COMMUNICATION_BY_ELECTRICAL_COUPLING","pval":0.60876,"padj":0.94703,"ES":0.69363,"NES":0.93473,"nMoreExtreme":38301,"size":23,"leadingEdge":["ATP1B2","CAMK2D","SRI","GJD3","SLC8A1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MACROPHAGE_CHEMOTAXIS","pval":0.69927,"padj":0.94995,"ES":0.73625,"NES":0.93469,"nMoreExtreme":39470,"size":10,"leadingEdge":["CCL5","CSF1","MAPK3"]} {"pathway":"GO_REGULATION_OF_DELAYED_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY","pval":0.68431,"padj":0.94976,"ES":0.73806,"NES":0.93462,"nMoreExtreme":39472,"size":12,"leadingEdge":["KCNE5","RNF207","KCNE1","KCNE1B","KCNG1"]} {"pathway":"GO_INORGANIC_ANION_TRANSPORT","pval":0.61387,"padj":0.94703,"ES":0.56166,"NES":0.9346,"nMoreExtreme":49061,"size":111,"leadingEdge":["APOL1","SLC37A1","SLC12A3","ANO4","ABCB1","CLIC5","SLC12A7","SLC26A11","SLC4A10","PTAFR","CLCN4","GABRR2","ADAMTS8","CLIC2","SLC25A30"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORT","pval":0.62357,"padj":0.94878,"ES":0.70768,"NES":0.93428,"nMoreExtreme":38545,"size":20,"leadingEdge":["ATP1B2","GLRX"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS","pval":0.6423,"padj":0.94878,"ES":0.53632,"NES":0.93371,"nMoreExtreme":56016,"size":199,"leadingEdge":["LRRK2","NUB1","RNF19B","PYHIN1","AMER1","TNFAIP3","EDEM1","RNF144B","TNF","GCLC","CTSC","NFE2L2","IL33","HERPUD1","NUPR1","RNF19A"]} {"pathway":"GO_NEUTRAL_LIPID_METABOLIC_PROCESS","pval":0.60529,"padj":0.94703,"ES":0.57768,"NES":0.93363,"nMoreExtreme":46167,"size":83,"leadingEdge":["GK","PLAAT3","ACSL1","C3","DGAT2","DGKG","NR1H3","LMF1","SIK1","INSIG2","CPT1A","FABP4"]} {"pathway":"GO_G_PROTEIN_COUPLED_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY","pval":0.69915,"padj":0.94995,"ES":0.72283,"NES":0.93297,"nMoreExtreme":38523,"size":8,"leadingEdge":["GRM8","HOMER2"]} {"pathway":"GO_CELLULAR_GLUCOSE_HOMEOSTASIS","pval":0.62049,"padj":0.94878,"ES":0.5587,"NES":0.93261,"nMoreExtreme":49868,"size":115,"leadingEdge":["ICAM1","SIDT2","SRI","GCLC","UCP2","GAS6","LIN28A","NADK","PIM3"]} {"pathway":"GO_ISOTYPE_SWITCHING_TO_IGG_ISOTYPES","pval":0.69594,"padj":0.94995,"ES":0.73479,"NES":0.93048,"nMoreExtreme":39737,"size":11,"leadingEdge":["CD40","TBX21","PTPRC"]} {"pathway":"GO_ACYLGLYCEROL_TRANSPORT","pval":0.51519,"padj":0.92459,"ES":0.62357,"NES":0.93009,"nMoreExtreme":25889,"size":2,"leadingEdge":["VAMP7","CD36"]} {"pathway":"GO_ACTIN_FILAMENT_ORGANIZATION","pval":0.68925,"padj":0.94995,"ES":0.51951,"NES":0.92993,"nMoreExtreme":64477,"size":344,"leadingEdge":["PSTPIP2","PLEK","MSRB1","JAK2","SPTBN4","ICAM1","SCIN","XIRP1","TMSB10","FAM107A","RHOBTB3","S100A10","PTGER4","PPM1E","RND1","ARHGAP25","CD47","CXCL12","ACTR3C","RHOH","PAK1","SRC","ARHGAP17","CDC42EP2","RHOQ","ACTN2","LPAR1","CX3CL1","AP1AR","PPARGC1B","SMAD3","SPTA1","SLIT2","C9orf72","MARCKS","RUFY3","COBL","MET","PROX1","LIMK1"]} {"pathway":"GO_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS","pval":0.61419,"padj":0.94703,"ES":0.57247,"NES":0.92972,"nMoreExtreme":47198,"size":87,"leadingEdge":["GCH1","ACOD1","AGT","ZC3H12A","TNF","FPR2","TGFB1","CDKN1A","PARL","NFE2L2","PDGFB"]} {"pathway":"GO_CELL_MIGRATION_INVOLVED_IN_GASTRULATION","pval":0.70073,"padj":0.94995,"ES":0.72021,"NES":0.92958,"nMoreExtreme":38610,"size":8,"leadingEdge":["AMOT","MEGF8"]} {"pathway":"GO_REGULATION_OF_DNA_RECOMBINATION","pval":0.61316,"padj":0.94703,"ES":0.57501,"NES":0.92932,"nMoreExtreme":46767,"size":83,"leadingEdge":["CD40","TBX21","RMI2","BCL6","PARP3","PTPRC","TGFB1","CGAS","HELB"]} {"pathway":"GO_REGULATION_OF_LYMPHOCYTE_CHEMOTAXIS","pval":0.63007,"padj":0.94878,"ES":0.70382,"NES":0.92919,"nMoreExtreme":38947,"size":20,"leadingEdge":["CXCL10","PADI2","CCL7","CCL5","CCL4","CCL2","CCL3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ION_TRANSPORT","pval":0.62411,"padj":0.94878,"ES":0.56003,"NES":0.92815,"nMoreExtreme":49579,"size":106,"leadingEdge":["CAMK2D","ICAM1","SRI","DYSF","KCNE5","GEM","LILRB1","KCNE1","TGFB1","SNX16","ACTN2","GPM6B","PTGS2","MIR212","SPINK1","CLIC2","KCNE1B","GPR35"]} {"pathway":"GO_ACTIN_FILAMENT_BASED_PROCESS","pval":0.75032,"padj":0.9603,"ES":0.50991,"NES":0.92812,"nMoreExtreme":73539,"size":635,"leadingEdge":["PDE4B","PSTPIP2","PLEK","AMOT","LIMK2","MSRB1","JAK2","KCNJ2","CAMK2D","SPTBN4","ICAM1","SRI","FRMD3","STAP1","SCIN","XIRP1","TMSB10","EDN1","NRK","FAM107A","RHOBTB3","ANK2","S100A10","FMNL2","MRAS","PTGER4","BCL6","PPM1E","DTNBP1","KCNE5","RND1","MYH7","RNF207","ARHGAP25","FGF10","TNF","DES","CD47","FARP2","FGD2","CXCL12","ACTR3C","RHOH","AUTS2","KCNE1","SH2B2","PAK1","MYO1E","NUAK2","SRC","TGFB1","ARHGAP17","IQSEC3","CDC42EP2","PDGFRA","PTPN1","RHOQ","ACTN2","LPAR1","GPM6B","CX3CL1","AP1AR","CFLAR","PPARGC1B","SMAD3","FGD6","SPTA1","SLIT2","KCNE1B","MYOZ1","C9orf72","ARHGEF11","MARCKS","CXCL1"]} {"pathway":"GO_MEMBRANE_DEPOLARIZATION_DURING_ACTION_POTENTIAL","pval":0.60765,"padj":0.94703,"ES":0.66741,"NES":0.92749,"nMoreExtreme":39252,"size":28,"leadingEdge":["KCNJ2","ANK2","SLC8A1","SCN9A","CACNA1I","SCN3A"]} {"pathway":"GO_REGULATION_OF_CELL_MATURATION","pval":0.64211,"padj":0.94878,"ES":0.71184,"NES":0.92707,"nMoreExtreme":39066,"size":18,"leadingEdge":["LRRK2","SIRT2"]} {"pathway":"GO_B_CELL_APOPTOTIC_PROCESS","pval":0.6186,"padj":0.94878,"ES":0.68792,"NES":0.92704,"nMoreExtreme":38920,"size":23,"leadingEdge":["CD74","BCL2L11","BCL6","LYN","BAK1"]} {"pathway":"GO_CHOLESTEROL_STORAGE","pval":0.6583,"padj":0.94878,"ES":0.72161,"NES":0.92703,"nMoreExtreme":39433,"size":16,"leadingEdge":["SOAT1","TTC39B","NR1H3","EHD1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MUSCLE_HYPERTROPHY","pval":0.62216,"padj":0.94878,"ES":0.69224,"NES":0.92678,"nMoreExtreme":38929,"size":22,"leadingEdge":["P2RX4","PAK1","SMAD3","TNFRSF1B"]} {"pathway":"GO_REGULATION_OF_REMOVAL_OF_SUPEROXIDE_RADICALS","pval":0.70238,"padj":0.95003,"ES":0.71748,"NES":0.92606,"nMoreExtreme":38701,"size":8,"leadingEdge":["GCH1","TNF","NFE2L2"]} {"pathway":"GO_PHOSPHOLIPID_HOMEOSTASIS","pval":0.69394,"padj":0.94995,"ES":0.70795,"NES":0.92605,"nMoreExtreme":37719,"size":7,"leadingEdge":["LIPG","APOA1"]} {"pathway":"GO_ENGULFMENT_OF_APOPTOTIC_CELL","pval":0.67454,"padj":0.94976,"ES":0.72766,"NES":0.92602,"nMoreExtreme":39703,"size":14,"leadingEdge":["XKR6","XKR8","ADGRB1","XKR7","RHOBTB2"]} {"pathway":"GO_REGULATION_OF_INOSITOL_PHOSPHATE_BIOSYNTHETIC_PROCESS","pval":0.69951,"padj":0.94995,"ES":0.73107,"NES":0.92577,"nMoreExtreme":39941,"size":11,"leadingEdge":["PLEK","PTAFR","CD244"]} {"pathway":"GO_CRANIAL_SKELETAL_SYSTEM_DEVELOPMENT","pval":0.60945,"padj":0.94703,"ES":0.60039,"NES":0.92559,"nMoreExtreme":43600,"size":56,"leadingEdge":["TIFAB","CHST11","AUTS2","TGFB1","PDGFRA","SMAD3","PAX5","INSIG2","TBX1","NEUROG1","SIX1"]} {"pathway":"GO_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS","pval":0.72587,"padj":0.95562,"ES":0.51226,"NES":0.92554,"nMoreExtreme":69590,"size":455,"leadingEdge":["CD40","TBX21","XRN1","RMI2","PML","ZC3H12A","DTX3L","BCL6","OAS2","PARP3","OAS3","PARP9","ANXA3","FGF10","RBM11","PTPRC","NBN","SRC","TGFB1","CGAS","HELB","STN1","OTUD4","GATA3","LIN28A","ZFP36","OASL","KDM1B"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION","pval":0.60771,"padj":0.94703,"ES":0.63858,"NES":0.92388,"nMoreExtreme":40709,"size":36,"leadingEdge":["AGT","CCL5","NR4A3","PAK1","SRC","LPAR1","HAS2","PDGFB","HDAC4"]} {"pathway":"GO_LINOLEIC_ACID_METABOLIC_PROCESS","pval":0.70648,"padj":0.9508,"ES":0.72754,"NES":0.92363,"nMoreExtreme":39877,"size":10,"leadingEdge":["ACSL1","ELOVL5"]} {"pathway":"GO_RESPONSE_TO_ALCOHOL","pval":0.65878,"padj":0.94878,"ES":0.53581,"NES":0.92357,"nMoreExtreme":56265,"size":172,"leadingEdge":["GRIN3A","CCL7","XRN1","VCAM1","ICAM1","KLF4","GRAMD1B","POLB","PTGER4","PTGER2","CCR5","STAT3","TGFB1","CCL19","CDKN1A","CCL3","GATA3","SLIT2","BAK1"]} {"pathway":"GO_REGULATION_OF_CYTOSKELETON_ORGANIZATION","pval":0.73481,"padj":0.95787,"ES":0.51063,"NES":0.92351,"nMoreExtreme":70649,"size":471,"leadingEdge":["P2RX7","PLEK","SPTBN4","ICAM1","CYLD","STAP1","SCIN","ATF5","TMSB10","EDN1","FAM107A","RHOBTB3","S100A10","CHMP4C","PTGER4","PPM1E","PARP3","RND1","CD47","CXCL12","ACTR3C","RHOH","PAK1","TGFB1","ARHGAP17","CDC42EP2","STMN3","STMND1","PDGFRA","RHOQ","ACTN2","MAP2","PKHD1","LPAR1","GPM6B","CX3CL1","AP1AR","SMAD3","SPTA1","SLIT2"]} {"pathway":"GO_RESPONSE_TO_GRANULOCYTE_MACROPHAGE_COLONY_STIMULATING_FACTOR","pval":0.70777,"padj":0.9508,"ES":0.72295,"NES":0.92343,"nMoreExtreme":39552,"size":9,"leadingEdge":["ZFP36","CD4"]} {"pathway":"GO_ENDOTHELIAL_CELL_PROLIFERATION","pval":0.64052,"padj":0.94878,"ES":0.55084,"NES":0.92316,"nMoreExtreme":51840,"size":120,"leadingEdge":["STAT1","VEGFC","MIR503","DYSF","PRKX","EGR3","TNF","STAT5A","FLT1","CXCL12","F3","CCL2","STAT3","PDGFB","PPP1R16B","ALDH1A2","PROX1"]} {"pathway":"GO_MUSCLE_CELL_DIFFERENTIATION","pval":0.69209,"padj":0.94995,"ES":0.52056,"NES":0.92279,"nMoreExtreme":63075,"size":278,"leadingEdge":["CXCL10","CXCL9","AGT","MYOF","BHLHE41","FLT3LG","EDN1","ANK2","COMP","DYSF","SOD2","STAC3","FGF10","PLEKHO1","SLC8A1","TRIM72","PAK1","TGFB1","PDGFRA","SORT1","ACTN2","ADGRB1","RIPOR2","CFLAR","CD53","PDGFB","SIK1","MYOZ1","BOC","FLOT1","NFATC1","EREG","TBX1","PROX1","MAPK11","WNT1"]} {"pathway":"GO_SECONDARY_METABOLIC_PROCESS","pval":0.60942,"padj":0.94703,"ES":0.62744,"NES":0.92275,"nMoreExtreme":41540,"size":40,"leadingEdge":["CYP1A1","SQOR","RAPGEF2","CTNS","NFE2L2","CBSL"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NEUTROPHIL_MIGRATION","pval":0.62782,"padj":0.94878,"ES":0.68897,"NES":0.9224,"nMoreExtreme":39283,"size":22,"leadingEdge":["CD74","EDN1","DYSF","CAMK1D","CCL19","CXCL8","RIPOR2","DAPK2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT","pval":0.63112,"padj":0.94878,"ES":0.5626,"NES":0.92199,"nMoreExtreme":49173,"size":95,"leadingEdge":["CXCL10","AMOT","STAT1","AGT","KLF4","PML","NPR1","MIR503","HLA-G","SEMA4A","ADGRB1","FOXC1","MIR212","PDGFB"]} {"pathway":"GO_POSITIVE_CHEMOTAXIS","pval":0.61603,"padj":0.94834,"ES":0.59782,"NES":0.92163,"nMoreExtreme":44071,"size":56,"leadingEdge":["CXCL10","HGF","CCL15","VEGFC","CCL5","FGF10","CXCL12","FPR2","F3","CXCL8","CCL3","CX3CL1","PDGFB","SMAD3","SAA2","MET"]} {"pathway":"GO_SULFUR_COMPOUND_BIOSYNTHETIC_PROCESS","pval":0.65518,"padj":0.94878,"ES":0.54027,"NES":0.92156,"nMoreExtreme":54821,"size":149,"leadingEdge":["ACSL1","CNDP2","GSTK1","GGT5","CHAC1","DSE","B4GALT5","CHST11","ACSL5","ELOVL7","GCLC","ACSS1","CHST2","NFE2L2"]} {"pathway":"GO_REGULATION_OF_PROTEIN_MATURATION","pval":0.61382,"padj":0.94703,"ES":0.608,"NES":0.92121,"nMoreExtreme":43070,"size":49,"leadingEdge":["LRRK2","CARD16","CHAC1","BIRC3","CTSZ","HPN","SRC","PLGRKT","BIRC7","IL1R2"]} {"pathway":"GO_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING","pval":0.61227,"padj":0.94703,"ES":0.61738,"NES":0.92112,"nMoreExtreme":42361,"size":44,"leadingEdge":["GBP1","S100A10","HAS2","AP1AR"]} {"pathway":"GO_APPENDAGE_DEVELOPMENT","pval":0.65498,"padj":0.94878,"ES":0.54181,"NES":0.92059,"nMoreExtreme":54383,"size":142,"leadingEdge":["KREMEN1","BCL2L11","COMP","FGF10","CHST11","BAK1","ALDH1A2"]} {"pathway":"GO_ORGANIC_CATION_TRANSPORT","pval":0.62007,"padj":0.94878,"ES":0.67047,"NES":0.92052,"nMoreExtreme":39673,"size":26,"leadingEdge":["SLC25A45","AZIN2","SLC22A1","SLC44A2","ADORA2A","SLC22A16"]} {"pathway":"GO_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING","pval":0.63058,"padj":0.94878,"ES":0.56887,"NES":0.92046,"nMoreExtreme":48179,"size":84,"leadingEdge":["GBP1","LRRK2","PLEK","CAMK2D","SRI","P2RX4","JPH4","TNF","CCL4","CCL3","CLIC2","MYOZ1"]} {"pathway":"GO_RESPONSE_TO_PEPTIDE_HORMONE","pval":0.71225,"padj":0.95313,"ES":0.51478,"NES":0.91994,"nMoreExtreme":66303,"size":331,"leadingEdge":["SOCS1","CEACAM1","TNFSF10","EGR2","STAT1","JAK2","AGT","ICAM1","JAK3","EDN1","CISH","LYN","NR4A3","STAT5A","VGF","TRIM72","CXCL12","NR4A2","SOCS3","SH2B2","STAT3","PTPN2","PAK1","GCLC","SRC","TGFB1","UCP2","ATP6V1A","PTPN1","RHOQ","SORT1","ACTN2","PTGS2","CFLAR","AGTRAP","NFE2L2"]} {"pathway":"GO_TRIPARTITE_REGIONAL_SUBDIVISION","pval":0.70389,"padj":0.9504,"ES":0.72642,"NES":0.91988,"nMoreExtreme":40191,"size":11,"leadingEdge":["TIFAB","HOXD8","NEUROG1"]} {"pathway":"GO_NERVOUS_SYSTEM_PROCESS","pval":0.77527,"padj":0.96098,"ES":0.50531,"NES":0.91983,"nMoreExtreme":76018,"size":639,"leadingEdge":["P2RX7","LRRK2","HLA-DRA","GCH1","HGF","EGR2","GRIN3A","KCNJ10","AGT","TYMP","SPTBN4","ICAM1","RTP4","GRM8","PRRT2","RASGRF1","CBR3","P2RX4","MARVELD2","EDN1","FAM107A","CLIC5","COMP","CTNS","TIFAB","NR4A3","NRCAM","SOD2","ATXN7","JPH4","TNF","HPN","SCN9A","CXCL12","PTAFR","KCNE1","CCL2","CACNA1I","NBN","GUCA1A","SRC","VAX2","GM2A","GABRR2","PTGS2","RIPOR2","CCL3","ACPP","RGS9","PLCB1","GLS","SLC8A2","TECTA","PDZD7","RORB","NGF","OR2A5","SHISA7"]} {"pathway":"GO_REGULATION_OF_VITAMIN_D_BIOSYNTHETIC_PROCESS","pval":0.70547,"padj":0.9508,"ES":0.71264,"NES":0.91982,"nMoreExtreme":38871,"size":8,"leadingEdge":["TNF","CYP27B1","SNAI2"]} {"pathway":"GO_TRANSITION_METAL_ION_HOMEOSTASIS","pval":0.64335,"padj":0.94878,"ES":0.5522,"NES":0.91975,"nMoreExtreme":51519,"size":112,"leadingEdge":["ATP13A2","SLC31A2","STEAP4","SRI","B2M","SCO2","SLC25A28","MT2A","MT1M","CUL1","MT1E","MT1H","ATP6V1A","MT1G","NCOA4","SLC31A1","SLC30A4"]} {"pathway":"GO_BASE_CONVERSION_OR_SUBSTITUTION_EDITING","pval":0.66626,"padj":0.94905,"ES":0.71576,"NES":0.91951,"nMoreExtreme":39910,"size":16,"leadingEdge":["APOBEC3D","APOBEC3A","APOBEC3G","APOBEC3F","ADAR"]} {"pathway":"GO_HIS_PURKINJE_SYSTEM_DEVELOPMENT","pval":0.52484,"padj":0.92669,"ES":0.62405,"NES":0.91941,"nMoreExtreme":26830,"size":3,"leadingEdge":["DSG2","ID2","TBX3"]} {"pathway":"GO_ESTROUS_CYCLE","pval":0.69688,"padj":0.94995,"ES":0.72573,"NES":0.91901,"nMoreExtreme":40197,"size":12,"leadingEdge":["NCOA1","HAS2","PTN"]} {"pathway":"GO_CELL_PROLIFERATION_IN_BONE_MARROW","pval":0.69665,"padj":0.94995,"ES":0.70228,"NES":0.91863,"nMoreExtreme":37866,"size":7,"leadingEdge":["FLT3LG","FGFR2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NK_T_CELL_ACTIVATION","pval":0.69665,"padj":0.94995,"ES":0.70227,"NES":0.91863,"nMoreExtreme":37866,"size":7,"leadingEdge":["IL12A","RASAL3"]} {"pathway":"GO_VITAMIN_D_RECEPTOR_SIGNALING_PATHWAY","pval":0.70619,"padj":0.9508,"ES":0.71145,"NES":0.91827,"nMoreExtreme":38911,"size":8,"leadingEdge":["PIM1","CYP27B1","SNAI2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION","pval":0.83282,"padj":0.97443,"ES":0.50164,"NES":0.9179,"nMoreExtreme":82942,"size":1021,"leadingEdge":["GBP5","AIM2","P2RX7","CALCOCO2","LRRK2","PLEK","HGF","TNFSF10","CXCL9","OPTN","AGT","ICAM1","SCARF1","BCL2L11","MUC1","FLT3LG","PML","B2M","C3","RAPGEF2","STAP1","SCIN","ENPP2","RALB","EDN1","PMAIP1","C21orf91","S100A10","BCL6","PPM1E","LYN","TRABD2A","NPM2","IL6","SEMA7A","TNF","CD47","CAMK1D","SMPD3","NTN1","CXCL12","ACTR3C","AUTS2","NBN","P2RY12","PAK1","SRC","TGFB1","SEMA4A","CDC42EP2","OCSTAMP","ROBO1","CCL19","UVRAG","RHOQ","ACTN2","ADGRB1","LIG4","LPAR1","TPPP","RIPOR2","HAS2","CX3CL1","AP1AR","CFLAR","GATA3","NFE2L2","SEMA4D","CD53","BBC3","PLCB1","PDGFB","SMAD3","SYT17","SLIT2","BAK1","IL1A","DDHD1"]} {"pathway":"GO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY","pval":0.63837,"padj":0.94878,"ES":0.56483,"NES":0.91731,"nMoreExtreme":49056,"size":87,"leadingEdge":["MYOF","VEGFC","NCF1","FGF10","FLT1","SRC","PTPN1","NCF2","FOXC1","ELMO2","MAPK11"]} {"pathway":"GO_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT","pval":0.74238,"padj":0.95912,"ES":0.50861,"NES":0.91702,"nMoreExtreme":70753,"size":425,"leadingEdge":["LRRK2","CD38","HGF","KREMEN1","AGT","KLF4","SCARF1","B2M","RAPGEF2","C21orf91","LYN","NRCAM","CTSZ","SEMA7A","CAMK1D","MOV10","NTN1","CXCL12","PAK1","SEMA4A","ROBO1","MAP2","RGMA","LPAR1","CX3CL1","CFLAR","GATA3","NFE2L2","SRCIN1","SEMA4D","SYT17","DENND5A","SLIT2","TRIM46","NGF","ARC","RUFY3","COBL","MCF2","LIMK1","PTN","LZTS1","SEMA3F"]} {"pathway":"GO_POSITIVE_REGULATION_OF_LIPID_STORAGE","pval":0.66917,"padj":0.94905,"ES":0.71378,"NES":0.91696,"nMoreExtreme":40084,"size":16,"leadingEdge":["C3","ZC3H12A","IKBKE","EHD1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ISOTYPE_SWITCHING","pval":0.6272,"padj":0.94878,"ES":0.67154,"NES":0.9164,"nMoreExtreme":39954,"size":25,"leadingEdge":["CD40","TBX21","PTPRC","TGFB1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_HYDROGEN_PEROXIDE_BIOSYNTHETIC_PROCESS","pval":0.62616,"padj":0.94878,"ES":0.6875,"NES":0.91635,"nMoreExtreme":31331,"size":1,"leadingEdge":["ZNF205"]} {"pathway":"GO_CELL_COMMUNICATION_BY_ELECTRICAL_COUPLING_INVOLVED_IN_CARDIAC_CONDUCTION","pval":0.64609,"padj":0.94878,"ES":0.69364,"NES":0.91574,"nMoreExtreme":39937,"size":20,"leadingEdge":["ATP1B2","CAMK2D","SRI","GJD3","SLC8A1"]} {"pathway":"GO_EMBRYONIC_AXIS_SPECIFICATION","pval":0.62685,"padj":0.94878,"ES":0.66691,"NES":0.91563,"nMoreExtreme":40107,"size":26,"leadingEdge":["TIFAB","HOXD8","COBL","NEUROG1","WNT1"]} {"pathway":"GO_NATURAL_KILLER_CELL_DIFFERENTIATION","pval":0.6627,"padj":0.94905,"ES":0.70801,"NES":0.91561,"nMoreExtreme":40046,"size":17,"leadingEdge":["IL15","FLT3LG","RASGRP1","PTPRC","GAS6"]} {"pathway":"GO_EPIDERMAL_CELL_DIFFERENTIATION","pval":0.66009,"padj":0.94905,"ES":0.54354,"NES":0.91521,"nMoreExtreme":53868,"size":127,"leadingEdge":["OVOL1","KLF4","MAFF","CTSL","CYP27B1","RUNX1","TXNIP","FOXC1","PDZD7","ZFP36","EREG"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_EARLY_ENDOSOME","pval":0.70774,"padj":0.9508,"ES":0.70904,"NES":0.91517,"nMoreExtreme":38996,"size":8,"leadingEdge":["DTX3L","EZR"]} {"pathway":"GO_MEMBRANE_INVAGINATION","pval":0.63201,"padj":0.94878,"ES":0.5824,"NES":0.91513,"nMoreExtreme":46377,"size":65,"leadingEdge":["C3","STAP1","XKR6","ARHGAP25","XKR8","FCGR1A","ADGRB1","XKR7","FCER1G"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION","pval":0.64608,"padj":0.94878,"ES":0.55708,"NES":0.9149,"nMoreExtreme":50497,"size":97,"leadingEdge":["GBP1","LRRK2","LILRB4","TXN","KCNE1","TGFB1","RHOQ","ACTN2","GPM6B","RIPOR2","ANKRD13A"]} {"pathway":"GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR","pval":0.63321,"padj":0.94878,"ES":0.57695,"NES":0.91482,"nMoreExtreme":47022,"size":70,"leadingEdge":["CD74","MUC1","PML","TMEM109","PMAIP1","NUPR1"]} {"pathway":"GO_GLOMERULAR_EPITHELIAL_CELL_DIFFERENTIATION","pval":0.69355,"padj":0.94995,"ES":0.72192,"NES":0.9148,"nMoreExtreme":40392,"size":13,"leadingEdge":["MYO1E","PODXL","PROM1"]} {"pathway":"GO_INTERLEUKIN_2_BIOSYNTHETIC_PROCESS","pval":0.65644,"padj":0.94878,"ES":0.70224,"NES":0.91457,"nMoreExtreme":39938,"size":18,"leadingEdge":["LAG3","CD80","IRF4","CD86","PTPRC","ZFP36","IL1A","PRKCQ"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT","pval":0.66395,"padj":0.94905,"ES":0.54008,"NES":0.91416,"nMoreExtreme":54717,"size":135,"leadingEdge":["LRRK2","CD38","KREMEN1","B2M","RAPGEF2","CTSZ","SEMA7A","NTN1","SEMA4A","MAP2","RGMA","LPAR1","SEMA4D","DENND5A","SLIT2","TRIM46","RUFY3","MCF2","SEMA3F"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_NECROTIC_CELL_DEATH","pval":0.68616,"padj":0.94976,"ES":0.71824,"NES":0.91402,"nMoreExtreme":40387,"size":14,"leadingEdge":["BIRC3","RBCK1","CFLAR","YBX3"]} {"pathway":"GO_CRANIAL_SUTURE_MORPHOGENESIS","pval":0.70835,"padj":0.95117,"ES":0.70792,"NES":0.91372,"nMoreExtreme":39030,"size":8,"leadingEdge":["TGFB1","INSIG2","GLI3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_HORMONE_BIOSYNTHETIC_PROCESS","pval":0.71326,"padj":0.9532,"ES":0.71532,"NES":0.91368,"nMoreExtreme":39859,"size":9,"leadingEdge":["TNF","HIF1A"]} {"pathway":"GO_REGULATION_OF_INTERLEUKIN_4_PRODUCTION","pval":0.63503,"padj":0.94878,"ES":0.67784,"NES":0.91345,"nMoreExtreme":39954,"size":23,"leadingEdge":["HLA-E","CD83","IRF4","CD86","GATA3","IL33","FCER1G","PRKCQ"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PHAGOCYTOSIS_ENGULFMENT","pval":0.70144,"padj":0.94995,"ES":0.72129,"NES":0.91339,"nMoreExtreme":40460,"size":12,"leadingEdge":["C3","STAP1","ABCA7"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS","pval":0.62362,"padj":0.94878,"ES":0.626,"NES":0.91338,"nMoreExtreme":42167,"size":38,"leadingEdge":["CEACAM1","CYP27B1","ERLIN1","PDGFB","SIK1","INSIG2","PROX1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ENDOCYTOSIS","pval":0.6425,"padj":0.94878,"ES":0.56652,"NES":0.91318,"nMoreExtreme":48814,"size":81,"leadingEdge":["LRRK2","B2M","C3","STAP1","CCL19","FLOT1"]} {"pathway":"GO_REGULATION_OF_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS","pval":0.65803,"padj":0.94878,"ES":0.70114,"NES":0.91313,"nMoreExtreme":40035,"size":18,"leadingEdge":["HLA-E","C3","LTA","TNF","FCER1G"]} {"pathway":"GO_ETHANOL_OXIDATION","pval":0.67483,"padj":0.94976,"ES":0.68265,"NES":0.91282,"nMoreExtreme":36217,"size":6,"leadingEdge":["ACSS1","ACSS2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS","pval":0.63726,"padj":0.94878,"ES":0.57831,"NES":0.91228,"nMoreExtreme":47004,"size":67,"leadingEdge":["ZC3H12A","DTX3L","PYHIN1","PARP9","SRC","TGFB1","PTGS2","SMAD3"]} {"pathway":"GO_DETECTION_OF_VIRUS","pval":0.67522,"padj":0.94976,"ES":0.68142,"NES":0.91117,"nMoreExtreme":36238,"size":6,"leadingEdge":["IFIH1","TLR3","DDX58"]} {"pathway":"GO_CELLULAR_TRANSITION_METAL_ION_HOMEOSTASIS","pval":0.65024,"padj":0.94878,"ES":0.55974,"NES":0.91092,"nMoreExtreme":50093,"size":89,"leadingEdge":["ATP13A2","SLC31A2","SRI","SCO2","MT2A","MT1M","CUL1","MT1E","MT1H","ATP6V1A","MT1G","NCOA4","SLC31A1","SLC30A4"]} {"pathway":"GO_REGULATION_OF_OSSIFICATION","pval":0.68049,"padj":0.94976,"ES":0.53297,"NES":0.91041,"nMoreExtreme":57083,"size":152,"leadingEdge":["P2RX7","HGF","KREMEN1","CHRD","EGR2","IFITM1","COMP","PTGER4","CSF1","IL6","TNF","SLC8A1","CYP27B1","TGFB1","ISG15","GPM6B","CCL3","SEMA4D","SMAD3","RORB"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PROGRAMMED_NECROTIC_CELL_DEATH","pval":0.69748,"padj":0.94995,"ES":0.71824,"NES":0.91014,"nMoreExtreme":40621,"size":13,"leadingEdge":["BIRC3","RBCK1","CFLAR","YBX3"]} {"pathway":"GO_RESPONSE_TO_MACROPHAGE_COLONY_STIMULATING_FACTOR","pval":0.71112,"padj":0.95246,"ES":0.71872,"NES":0.91012,"nMoreExtreme":40604,"size":11,"leadingEdge":["STAP1","CSF1","PTPN2","TLR4","DCSTAMP"]} {"pathway":"GO_CENTRAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION","pval":0.66977,"padj":0.94905,"ES":0.54069,"NES":0.91006,"nMoreExtreme":54635,"size":126,"leadingEdge":["SPTBN4","MDGA1","RAPGEF2","ATF5","C21orf91","B4GALT5","ASCL1","SLC4A10","NR4A2","AUTS2","ROBO1","ISL2","MAP2","SLIT2","PROX1","WNT1","BTG2","GDPD5"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SMALL_MOLECULE_METABOLIC_PROCESS","pval":0.64551,"padj":0.94878,"ES":0.5698,"NES":0.90964,"nMoreExtreme":48391,"size":74,"leadingEdge":["PMAIP1","DGAT2","NR4A3","TNF","PTAFR","NR1H3","PTPN2","SRC","PTGS2","ESRRB","CPT1A","CD244","LPGAT1"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_SALT","pval":0.67559,"padj":0.94976,"ES":0.68025,"NES":0.90961,"nMoreExtreme":36258,"size":6,"leadingEdge":["ZC3H12A","HNRNPA1"]} {"pathway":"GO_REGULATION_OF_BICELLULAR_TIGHT_JUNCTION_ASSEMBLY","pval":0.65756,"padj":0.94878,"ES":0.69346,"NES":0.90932,"nMoreExtreme":40385,"size":19,"leadingEdge":["TNF","RUNX1","SNAI2"]} {"pathway":"GO_HISTONE_UBIQUITINATION","pval":0.63085,"padj":0.94878,"ES":0.60722,"NES":0.90912,"nMoreExtreme":43797,"size":45,"leadingEdge":["DTX3L","UBE2A","PCGF5","KDM1A"]} {"pathway":"GO_VITAMIN_D3_METABOLIC_PROCESS","pval":0.58112,"padj":0.94167,"ES":0.63832,"NES":0.909,"nMoreExtreme":30244,"size":4,"leadingEdge":["CYP27B1","CYP27A1"]} {"pathway":"GO_STRIATED_MUSCLE_CELL_DIFFERENTIATION","pval":0.7022,"padj":0.95003,"ES":0.52075,"NES":0.9088,"nMoreExtreme":61591,"size":208,"leadingEdge":["CXCL10","CXCL9","AGT","MYOF","BHLHE41","FLT3LG","EDN1","COMP","DYSF","STAC3","PLEKHO1","SLC8A1","TRIM72","PAK1","TGFB1","PDGFRA","SORT1","ACTN2","ADGRB1","RIPOR2","CFLAR","CD53","SIK1","MYOZ1","FLOT1"]} {"pathway":"GO_PROTEIN_DEPHOSPHORYLATION","pval":0.72651,"padj":0.95562,"ES":0.51259,"NES":0.90854,"nMoreExtreme":66191,"size":277,"leadingEdge":["LMTK2","JAK2","DAPP1","PPM1E","PTPRU","TNF","DUSP10","PTPRC","PTPN2","PPM1N","TGFB1","DUSP5","PTPN1","PLPP1","ELFN1","PPTC7","MYOZ1","PPP1R16B","MTMR8","PTN","DUSP2","LILRB2","EIF2AK2"]} {"pathway":"GO_ARACHIDONIC_ACID_METABOLIC_PROCESS","pval":0.63327,"padj":0.94878,"ES":0.65366,"NES":0.90838,"nMoreExtreme":40907,"size":28,"leadingEdge":["CYP1A1","PLA2G4C","CBR1","PLA2G4A","PTGS2"]} {"pathway":"GO_BONE_TRABECULA_FORMATION","pval":0.71638,"padj":0.95386,"ES":0.71091,"NES":0.90805,"nMoreExtreme":40033,"size":9,"leadingEdge":["PPARGC1B","MMP2"]} {"pathway":"GO_MEMBRANE_DEPOLARIZATION_DURING_SA_NODE_CELL_ACTION_POTENTIAL","pval":0.63622,"padj":0.94878,"ES":0.66009,"NES":0.90801,"nMoreExtreme":33664,"size":5,"leadingEdge":["ANK2","CACNA1G"]} {"pathway":"GO_VENTRICULAR_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT","pval":0.63254,"padj":0.94878,"ES":0.61303,"NES":0.90786,"nMoreExtreme":43375,"size":42,"leadingEdge":["MYH7","TGFB1","FOXC1","HEG1","PROX1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TRANSFERASE_ACTIVITY","pval":0.71769,"padj":0.95427,"ES":0.51608,"NES":0.90774,"nMoreExtreme":64149,"size":239,"leadingEdge":["SOCS1","CEACAM1","DTX3L","MVP","GADD45B","PPM1E","LYN","DTNBP1","PARP3","TNFAIP3","DUSP10","PTPRC","RHOH","SOCS3","PTPN2","SRC","CDKN1A","ADAR","DUSP5","CDKN1C","PTPN1","SRCIN1","ZFP36"]} {"pathway":"GO_LONG_CHAIN_FATTY_ACID_TRANSPORT","pval":0.63485,"padj":0.94878,"ES":0.60403,"NES":0.90733,"nMoreExtreme":44187,"size":46,"leadingEdge":["ACSL1","SLC27A3","PLA2G4A","CPT1A","FABP4"]} {"pathway":"GO_REGULATION_OF_CHROMATIN_ORGANIZATION","pval":0.68748,"padj":0.94995,"ES":0.53051,"NES":0.90717,"nMoreExtreme":57824,"size":154,"leadingEdge":["LRRK2","PADI2","CAMK2D","MUC1","PARP10","BCL6","AUTS2","TGFB1","GATA3","PAX5","MTHFR"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION","pval":0.71149,"padj":0.95246,"ES":0.7026,"NES":0.90685,"nMoreExtreme":39203,"size":8,"leadingEdge":["CD74","NOD2","CCL19"]} {"pathway":"GO_POSTSYNAPTIC_MEMBRANE_ORGANIZATION","pval":0.63367,"padj":0.94878,"ES":0.63553,"NES":0.90678,"nMoreExtreme":41887,"size":33,"leadingEdge":["COLQ","SHISA7","RAPSN","PTN"]} {"pathway":"GO_MUSCLE_ADAPTATION","pval":0.6589,"padj":0.94878,"ES":0.55769,"NES":0.90653,"nMoreExtreme":50676,"size":88,"leadingEdge":["IL15","AGT","CAMK2D","KLF4","P2RX4","EDN1","NR4A3","MYH7","PAK1","CFLAR","SMAD3","MYOZ1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS","pval":0.70083,"padj":0.94995,"ES":0.71531,"NES":0.90642,"nMoreExtreme":40816,"size":13,"leadingEdge":["TNF","SREBF1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROGRAMMED_NECROTIC_CELL_DEATH","pval":0.53334,"padj":0.92816,"ES":0.60767,"NES":0.90638,"nMoreExtreme":26801,"size":2,"leadingEdge":["RIPK3","RIPK1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MYOBLAST_DIFFERENTIATION","pval":0.66572,"padj":0.94905,"ES":0.69595,"NES":0.90637,"nMoreExtreme":40503,"size":18,"leadingEdge":["CXCL10","TNF","SOX8","TGFB1","PRICKLE1"]} {"pathway":"GO_ENDOCRINE_PROCESS","pval":0.64079,"padj":0.94878,"ES":0.59183,"NES":0.90632,"nMoreExtreme":45499,"size":53,"leadingEdge":["HCAR2","SUCNR1","AGT","EDN1","CTSZ","CES1","GATA3","NKX3-1"]} {"pathway":"GO_UNSATURATED_FATTY_ACID_METABOLIC_PROCESS","pval":0.63805,"padj":0.94878,"ES":0.59791,"NES":0.90594,"nMoreExtreme":44770,"size":49,"leadingEdge":["ACSL1","CYP1A1","PLA2G4C","CBR1","PLA2G4A","PTGS2"]} {"pathway":"GO_SULFIDE_OXIDATION","pval":0.63662,"padj":0.94878,"ES":0.65858,"NES":0.90593,"nMoreExtreme":33685,"size":5,"leadingEdge":["SQOR","ETHE1"]} {"pathway":"GO_IMMUNE_RESPONSE_TO_TUMOR_CELL","pval":0.70131,"padj":0.94995,"ES":0.71485,"NES":0.90584,"nMoreExtreme":40844,"size":13,"leadingEdge":["CD274","CEACAM1","IL12A","CD226"]} {"pathway":"GO_NEURON_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_OXIDATIVE_STRESS","pval":0.71231,"padj":0.95313,"ES":0.70156,"NES":0.90552,"nMoreExtreme":39248,"size":8,"leadingEdge":["MCL1","HIF1A"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS","pval":0.65572,"padj":0.94878,"ES":0.56244,"NES":0.9055,"nMoreExtreme":49759,"size":80,"leadingEdge":["CD74","RMI2","MUC1","CXCL12","CGAS","HELB"]} {"pathway":"GO_XENOBIOTIC_METABOLIC_PROCESS","pval":0.64844,"padj":0.94878,"ES":0.57617,"NES":0.90535,"nMoreExtreme":47583,"size":65,"leadingEdge":["ACSL1","CYP1A1","CBR3","EPHX1","CES1"]} {"pathway":"GO_MESENCHYMAL_CELL_PROLIFERATION","pval":0.63624,"padj":0.94878,"ES":0.61769,"NES":0.90524,"nMoreExtreme":43214,"size":39,"leadingEdge":["CHRD","STAT1","TBX1","PTN","SIX1"]} {"pathway":"GO_REGULATION_OF_RESPONSE_TO_TUMOR_CELL","pval":0.71468,"padj":0.9532,"ES":0.71486,"NES":0.90523,"nMoreExtreme":40807,"size":11,"leadingEdge":["CD274","CEACAM1","IL12A","CD226"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INTERLEUKIN_18_PRODUCTION","pval":0.5343,"padj":0.92816,"ES":0.60689,"NES":0.90521,"nMoreExtreme":26849,"size":2,"leadingEdge":["DHX9","TLR2"]} {"pathway":"GO_SKELETAL_SYSTEM_MORPHOGENESIS","pval":0.70204,"padj":0.94999,"ES":0.52372,"NES":0.9052,"nMoreExtreme":60315,"size":179,"leadingEdge":["P2RX7","COMP","TIFAB","CHST11","SMPD3","AUTS2","TGFB1","PDGFRA","HAS2","HOXD8","FOXC1","PPARGC1B","SMAD3","PAX5","ARID5B","INSIG2","TBX1","COCH","NEUROG1","COL27A1","SIX1"]} {"pathway":"GO_REGULATION_OF_INTRACELLULAR_TRANSPORT","pval":0.76082,"padj":0.96082,"ES":0.50398,"NES":0.90503,"nMoreExtreme":71752,"size":374,"leadingEdge":["LRRK2","ATP13A2","GRIN3A","IFI27","ZC3H12A","NUCB1","LYN","DTNBP1","EDEM1","TXN","KCNE1","PAK1","SRC","TGFB1","PTPN1","ACTN2","MAP2","PTGS2","GAS6","PARL","DNAJC13","NAPA","SMAD3","STOM","PRR5L","FCER1G","TRIM46","ARC","GCC2","RUFY3","HAP1","CD84","ADORA2A"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_KINASE_ACTIVITY","pval":0.71336,"padj":0.9532,"ES":0.51779,"NES":0.90491,"nMoreExtreme":62778,"size":213,"leadingEdge":["SOCS1","CEACAM1","MVP","GADD45B","PPM1E","LYN","DTNBP1","TNFAIP3","DUSP10","PTPRC","RHOH","SOCS3","PTPN2","CDKN1A","ADAR","DUSP5","CDKN1C","PTPN1","SRCIN1"]} {"pathway":"GO_LONG_TERM_MEMORY","pval":0.64087,"padj":0.94878,"ES":0.65909,"NES":0.90488,"nMoreExtreme":41004,"size":26,"leadingEdge":["RASGRF1","CTNS","ARC"]} {"pathway":"GO_DENDRITIC_CELL_ANTIGEN_PROCESSING_AND_PRESENTATION","pval":0.71908,"padj":0.95459,"ES":0.71269,"NES":0.90478,"nMoreExtreme":40588,"size":10,"leadingEdge":["CD74","NOD2","CCL19"]} {"pathway":"GO_VITAMIN_D_BIOSYNTHETIC_PROCESS","pval":0.71913,"padj":0.95459,"ES":0.71264,"NES":0.90472,"nMoreExtreme":40591,"size":10,"leadingEdge":["TNF","CYP27B1","SNAI2"]} {"pathway":"GO_ASTROCYTE_ACTIVATION","pval":0.65893,"padj":0.94878,"ES":0.68512,"NES":0.9045,"nMoreExtreme":40731,"size":20,"leadingEdge":["IL6","TNF","FPR2","ADORA2A"]} {"pathway":"GO_LYMPH_VESSEL_DEVELOPMENT","pval":0.64698,"padj":0.94878,"ES":0.67096,"NES":0.90418,"nMoreExtreme":40706,"size":23,"leadingEdge":["VEGFC","FOXC1","HEG1","TBX1","PROX1","PKD1"]} {"pathway":"GO_AMELOGENESIS","pval":0.68229,"padj":0.94976,"ES":0.7037,"NES":0.90402,"nMoreExtreme":40870,"size":16,"leadingEdge":["FAM20A","TBX1"]} {"pathway":"GO_BRANCHING_INVOLVED_IN_MAMMARY_GLAND_DUCT_MORPHOGENESIS","pval":0.65107,"padj":0.94878,"ES":0.67517,"NES":0.90393,"nMoreExtreme":40738,"size":22,"leadingEdge":["PML","CSF1","SRC","TGFB1","LRP6"]} {"pathway":"GO_VIRAL_RNA_GENOME_REPLICATION","pval":0.63878,"padj":0.94878,"ES":0.64353,"NES":0.90385,"nMoreExtreme":41641,"size":30,"leadingEdge":["APOBEC3D","APOBEC3G","APOBEC3F","CXCL8","ATG5"]} {"pathway":"GO_REGULATION_OF_ACTIN_FILAMENT_ORGANIZATION","pval":0.72319,"padj":0.95562,"ES":0.51502,"NES":0.90373,"nMoreExtreme":64264,"size":229,"leadingEdge":["PLEK","SPTBN4","ICAM1","SCIN","TMSB10","S100A10","PTGER4","PPM1E","CD47","CXCL12","ACTR3C","PAK1","CDC42EP2","ACTN2","LPAR1","CX3CL1","AP1AR","SMAD3","SPTA1","SLIT2","C9orf72"]} {"pathway":"GO_ENDOCHONDRAL_BONE_MORPHOGENESIS","pval":0.64802,"padj":0.94878,"ES":0.58308,"NES":0.90361,"nMoreExtreme":46671,"size":58,"leadingEdge":["COMP","SMPD3","FOXC1","COCH","COL27A1","HOXA11"]} {"pathway":"GO_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS","pval":0.6388,"padj":0.94878,"ES":0.61658,"NES":0.90361,"nMoreExtreme":43388,"size":39,"leadingEdge":["P2RX7","TNF","PSEN2","SPPL2A","ERAP1","PRKCQ"]} {"pathway":"GO_LUNG_MORPHOGENESIS","pval":0.63953,"padj":0.94878,"ES":0.61015,"NES":0.90359,"nMoreExtreme":43854,"size":42,"leadingEdge":["CTSZ","FGF10","TNF","LAMA1"]} {"pathway":"GO_SYNAPTIC_VESICLE_PRIMING","pval":0.67524,"padj":0.94976,"ES":0.69866,"NES":0.90352,"nMoreExtreme":40804,"size":17,"leadingEdge":["ERC2","CADPS2","NAPA"]} {"pathway":"GO_IONOTROPIC_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY","pval":0.69674,"padj":0.94995,"ES":0.70961,"NES":0.90305,"nMoreExtreme":41010,"size":14,"leadingEdge":["GRIN3A","GRIN2D"]} {"pathway":"GO_POSITIVE_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS","pval":0.68339,"padj":0.94976,"ES":0.70287,"NES":0.90296,"nMoreExtreme":40936,"size":16,"leadingEdge":["TNF","MCL1","TLR4"]} {"pathway":"GO_REGULATION_OF_RESPIRATORY_BURST","pval":0.72028,"padj":0.95459,"ES":0.7112,"NES":0.90289,"nMoreExtreme":40656,"size":10,"leadingEdge":["SLAMF8","DUSP10","CAMK1D","GRN"]} {"pathway":"GO_MESONEPHRIC_TUBULE_MORPHOGENESIS","pval":0.64837,"padj":0.94878,"ES":0.58414,"NES":0.90283,"nMoreExtreme":46517,"size":57,"leadingEdge":["AGT","SOX8","TGFB1","GATA3","HOXD11","WNT1","HNF1B","SIX1","HOXA11"]} {"pathway":"GO_CONNECTIVE_TISSUE_DEVELOPMENT","pval":0.71894,"padj":0.95459,"ES":0.51644,"NES":0.90279,"nMoreExtreme":63320,"size":214,"leadingEdge":["PLAAT3","SCIN","EDN1","DGAT2","COMP","CSF1","AMER1","CHST11","SOX8","SMPD3","CHI3L1","SLC25A25","TGFB1","SNORC","CFLAR","PDGFB","SMAD3","ARID5B"]} {"pathway":"GO_RESPONSE_TO_IONIZING_RADIATION","pval":0.69142,"padj":0.94995,"ES":0.53154,"NES":0.90268,"nMoreExtreme":57357,"size":141,"leadingEdge":["CXCL10","CCL7","VCAM1","ICAM1","PML","TMEM109","POLB","TANK","PTPRC","TGFB1","CDKN1A","NAMPT","LIG4","GATA3","BAK1"]} {"pathway":"GO_VASCULOGENESIS","pval":0.65102,"padj":0.94878,"ES":0.57994,"NES":0.90256,"nMoreExtreme":47189,"size":60,"leadingEdge":["CEACAM1","AMOT","RAPGEF2","MYO1E","TGFB1","HAS2","HEG1"]} {"pathway":"GO_PIRNA_METABOLIC_PROCESS","pval":0.70246,"padj":0.95003,"ES":0.68998,"NES":0.90254,"nMoreExtreme":38182,"size":7,"leadingEdge":["PIWIL4","TDRD9","MOV10L1"]} {"pathway":"GO_L_AMINO_ACID_TRANSPORT","pval":0.64161,"padj":0.94878,"ES":0.60275,"NES":0.90243,"nMoreExtreme":44544,"size":45,"leadingEdge":["KCNJ10","AGT","CTNS","SLC25A22","SLC7A2"]} {"pathway":"GO_FAT_SOLUBLE_VITAMIN_BIOSYNTHETIC_PROCESS","pval":0.7103,"padj":0.95214,"ES":0.71263,"NES":0.90242,"nMoreExtreme":40971,"size":12,"leadingEdge":["TNF","CYP27B1","SNAI2"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_OXIDISED_LOW_DENSITY_LIPOPROTEIN_PARTICLE_STIMULUS","pval":0.72078,"padj":0.95459,"ES":0.71059,"NES":0.90211,"nMoreExtreme":40684,"size":10,"leadingEdge":["MYD88","SMPD3","TLR4","TICAM1"]} {"pathway":"GO_REGULATION_OF_INSULIN_SECRETION","pval":0.68384,"padj":0.94976,"ES":0.53735,"NES":0.90183,"nMoreExtreme":55482,"size":122,"leadingEdge":["CD38","JAK2","SIDT2","SRI","CCL5","GLUL","TNF","UCP2","NADK","CPT1A","PIM3"]} {"pathway":"GO_EMBRYONIC_CRANIAL_SKELETON_MORPHOGENESIS","pval":0.64191,"padj":0.94878,"ES":0.6132,"NES":0.9018,"nMoreExtreme":43755,"size":40,"leadingEdge":["CHST11","AUTS2","PDGFRA","SMAD3","PAX5","TBX1","SIX1"]} {"pathway":"GO_RESPONSE_TO_TUMOR_CELL","pval":0.67077,"padj":0.94905,"ES":0.69238,"NES":0.90173,"nMoreExtreme":40810,"size":18,"leadingEdge":["CD274","CEACAM1","IL12A","CD226","TXNIP"]} {"pathway":"GO_REGULATION_OF_KINASE_ACTIVITY","pval":0.83954,"padj":0.97458,"ES":0.49426,"NES":0.9017,"nMoreExtreme":82885,"size":741,"leadingEdge":["CD40","CD74","P2RX7","SOCS1","LRRK2","CXCL10","NOD2","CEACAM1","HGF","NLRC5","JAK2","AGT","RIPK2","ACSL1","KLF4","FAM20A","RAPGEF2","STAP1","RALB","EDN1","NCF1","NRK","CISH","MVP","GADD45B","SLAMF8","PPM1E","CCL5","LYN","DTNBP1","CSF1","TNFAIP3","TLR3","FGF10","TXN","GADD45G","TNF","FLT1","DUSP10","RASGRP1","FGD2","LCP2","PTPRC","CHI3L1","RHOH","FPR2","SOCS3","NBN","P2RY12","PTPN2","PAK1","SRC","TGFB1","ROBO1","CCL19","CDKN1A","UVRAG","PDGFRA","ADAR","DUSP5","CDKN1C","PTPN1","CCNL1","LPAR1","GAS6","TCIM","BIRC7","SRCIN1","CCNA1"]} {"pathway":"GO_PHOSPHATIDYLSERINE_METABOLIC_PROCESS","pval":0.6915,"padj":0.94995,"ES":0.70561,"NES":0.90152,"nMoreExtreme":41090,"size":15,"leadingEdge":["PLAAT3","PLA1A","PLA2G4A","OSBPL5"]} {"pathway":"GO_BRANCHING_INVOLVED_IN_SALIVARY_GLAND_MORPHOGENESIS","pval":0.6638,"padj":0.94905,"ES":0.68201,"NES":0.9004,"nMoreExtreme":41032,"size":20,"leadingEdge":["HGF","TGM2","FGF10","TNF","LAMA1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_DNA_BINDING","pval":0.64784,"padj":0.94878,"ES":0.59258,"NES":0.90022,"nMoreExtreme":45568,"size":50,"leadingEdge":["JAK2","KLF4","PYHIN1","IRF4","TXN","TGFB1","FOXC1","GATA3","NGF","GTF2B"]} {"pathway":"GO_VITAMIN_METABOLIC_PROCESS","pval":0.67712,"padj":0.94976,"ES":0.54668,"NES":0.89972,"nMoreExtreme":53120,"size":99,"leadingEdge":["CYP1A1","CBR3","MTHFD2","TNF","CBR1","TCN2","CYP27B1","GCLC","MMAA","AMN","ACPP","RFK","MTHFR","ALDH1A2"]} {"pathway":"GO_RESPONSE_TO_CALCIUM_ION","pval":0.6863,"padj":0.94976,"ES":0.53824,"NES":0.89925,"nMoreExtreme":55238,"size":116,"leadingEdge":["P2RX7","SUCNR1","CAMK2D","EDN1","GUCA1A","KCNMA1","SYT5","TXNIP","SYT17","KCNMB1","KCNMB4","JUNB"]} {"pathway":"GO_AMINO_ACID_TRANSPORT","pval":0.67809,"padj":0.94976,"ES":0.54638,"NES":0.89922,"nMoreExtreme":53196,"size":99,"leadingEdge":["SLC6A12","P2RX7","KCNJ10","AGT","CTNS","SLC25A22","KMO","SLC7A2","GLS","NFKBIE"]} {"pathway":"GO_REGULATION_OF_ENDOCYTOSIS","pval":0.71259,"padj":0.95313,"ES":0.5218,"NES":0.89909,"nMoreExtreme":60810,"size":171,"leadingEdge":["LRRK2","B2M","C3","STAP1","RAB20","NR1H3","LILRB1","SRC","CCL19","PTPN1","ANKRD13A","FLOT1","ARC"]} {"pathway":"GO_THYROID_HORMONE_GENERATION","pval":0.70368,"padj":0.9504,"ES":0.68731,"NES":0.89905,"nMoreExtreme":38248,"size":7,"leadingEdge":["HPN","GATA3","CPQ"]} {"pathway":"GO_CELLULAR_COMPONENT_MAINTENANCE","pval":0.64926,"padj":0.94878,"ES":0.59464,"NES":0.89854,"nMoreExtreme":45457,"size":48,"leadingEdge":["ERC2","MTHFR","DLG3"]} {"pathway":"GO_DISTAL_CONVOLUTED_TUBULE_DEVELOPMENT","pval":0.65392,"padj":0.94878,"ES":0.67357,"NES":0.89778,"nMoreExtreme":32720,"size":1,"leadingEdge":["PAX8"]} {"pathway":"GO_CHONDROCYTE_DEVELOPMENT","pval":0.64843,"padj":0.94878,"ES":0.61041,"NES":0.8977,"nMoreExtreme":44199,"size":40,"leadingEdge":["COMP","CHST11","SMPD3","COCH","COL27A1"]} {"pathway":"GO_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORT","pval":0.65101,"padj":0.94878,"ES":0.59244,"NES":0.89765,"nMoreExtreme":45680,"size":49,"leadingEdge":["ATP1B2","CAMK2D","GLRX","STOM"]} {"pathway":"GO_OXIDATION_REDUCTION_PROCESS","pval":0.8537,"padj":0.97645,"ES":0.49169,"NES":0.89746,"nMoreExtreme":84415,"size":768,"leadingEdge":["IDO1","ASPHD2","IDO2","MSRB1","STEAP4","IL4I1","VCAM1","CYP1A1","HSD3B7","SQOR","AIFM2","CMAHP","CBR3","HSD11B1","MTHFD2","C15orf48","DHRS9","NCF1","SCO2","GSTK1","DGAT2","NCF1B","NCF1C","TRABD2A","NR4A3","SOD2","TXN","DECR1","CBR1","CH25H","SLC25A22","IFI30","CYP27B1","SLC25A25","KMO","LDHAL6B","ACSS1","HPD","PRDX1","PTGS2","CYB561A3","GPD2","NCF2","PRELID1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS","pval":0.65929,"padj":0.94899,"ES":0.57779,"NES":0.89715,"nMoreExtreme":47624,"size":59,"leadingEdge":["DGAT2","TNF","SMPD3","NR1H3","FPR2","PTGS2","RAB38","AGAP2","LPGAT1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELL_MOTILITY","pval":0.73709,"padj":0.95787,"ES":0.51179,"NES":0.89707,"nMoreExtreme":65303,"size":224,"leadingEdge":["CHRD","PADI2","KLF4","IFITM1","STAP1","MIR503","SLAMF8","PTGER4","PTPRU","DUSP10","MIIP","GPR18","CXCL12","CCL2","STAT3","TGFB1","ROBO1","ADGRB1","RIPOR2","CX3CL1","AP1AR","GATA3","NFE2L2","IL33","MIR212","PLCB1","SLIT2"]} {"pathway":"GO_REGULATION_OF_NK_T_CELL_ACTIVATION","pval":0.72191,"padj":0.95512,"ES":0.70227,"NES":0.89701,"nMoreExtreme":40342,"size":9,"leadingEdge":["IL12A","RASAL3"]} {"pathway":"GO_MAINTENANCE_OF_PROTEIN_LOCATION_IN_NUCLEUS","pval":0.66391,"padj":0.94905,"ES":0.67442,"NES":0.89657,"nMoreExtreme":41319,"size":21,"leadingEdge":["PML","TXN","SP100"]} {"pathway":"GO_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT","pval":0.68557,"padj":0.94976,"ES":0.54093,"NES":0.8965,"nMoreExtreme":54461,"size":106,"leadingEdge":["P2RX7","LRRK2","GRIN3A","MCTP2","DTNBP1","LILRB1","KMO","GPM6B","NAPA","FLOT1"]} {"pathway":"GO_REGULATION_OF_MACROPHAGE_DIFFERENTIATION","pval":0.68294,"padj":0.94976,"ES":0.69308,"NES":0.89631,"nMoreExtreme":41269,"size":17,"leadingEdge":["CSF1","PTPN2","TGFB1","C1QC","CASP8"]} {"pathway":"GO_GLANDULAR_EPITHELIAL_CELL_DIFFERENTIATION","pval":0.64862,"padj":0.94878,"ES":0.62224,"NES":0.89622,"nMoreExtreme":43231,"size":35,"leadingEdge":["IL31RA","SIDT2","ASCL1","PROX1"]} {"pathway":"GO_GLUTAMINE_TRANSPORT","pval":0.58437,"padj":0.94167,"ES":0.62926,"NES":0.89608,"nMoreExtreme":30413,"size":4,"leadingEdge":["SLC38A7","SLC1A5","SLC1A4","SLC38A2"]} {"pathway":"GO_REGULATION_OF_GROWTH","pval":0.82131,"padj":0.97278,"ES":0.49362,"NES":0.89583,"nMoreExtreme":79802,"size":549,"leadingEdge":["SOCS1","CD38","CEACAM1","AGT","PIM1","CAMK2D","SPTBN4","BCL2L11","PML","NPR1","EDN1","NRK","FAM107A","CISH","MT2A","COLQ","BCL6","CSF1","LTA","IL7","NRCAM","CXCL16","MT1M","SEMA7A","NOTCH2","TNF","STAT5A","HPN","DUSP10","MT1E","NTN1","CXCL12","CYP27B1","SOCS3","STAT3","PAK1","TGFB1","SEMA4A","CDKN1A","MT1H","OGFR","CREG1","MAP2","GAS6","FOXC1","MT1G","SEMA4D","PLCB1","SMAD3","SYT17","SLIT2","MYOZ1","TRIM46","HLX","NGF","ARHGEF11","IRF8"]} {"pathway":"GO_CARDIAC_VENTRICLE_DEVELOPMENT","pval":0.68576,"padj":0.94976,"ES":0.542,"NES":0.89569,"nMoreExtreme":54202,"size":103,"leadingEdge":["MYH7","TGFB1","ROBO1","FOXC1","GATA3","SLIT2","HEG1","PROX1","SMARCD3","AP2B1"]} {"pathway":"GO_REGULATION_OF_DENDRITIC_SPINE_MORPHOGENESIS","pval":0.65261,"padj":0.94878,"ES":0.61071,"NES":0.895,"nMoreExtreme":44326,"size":39,"leadingEdge":["LRRK2","SRCIN1","ARC","ARHGAP33"]} {"pathway":"GO_NUCLEAR_POLYADENYLATION_DEPENDENT_TRNA_CATABOLIC_PROCESS","pval":0.63926,"padj":0.94878,"ES":0.65058,"NES":0.89493,"nMoreExtreme":33825,"size":5,"leadingEdge":["EXOSC7","EXOSC3","EXOSC8","EXOSC9","EXOSC2"]} {"pathway":"GO_RNA_SPLICING_VIA_TRANSESTERIFICATION_REACTIONS","pval":0.76909,"padj":0.96082,"ES":0.50152,"NES":0.89475,"nMoreExtreme":71274,"size":317,"leadingEdge":["RBM11","PRPF3","RBM5"]} {"pathway":"GO_NEURON_DIFFERENTIATION","pval":0.89647,"padj":0.98354,"ES":0.48877,"NES":0.89461,"nMoreExtreme":89349,"size":1082,"leadingEdge":["ASCL2","LRRK2","CD38","HGF","KREMEN1","EGR2","GRIN3A","JAK2","AGT","ONECUT2","GLDN","VCAM1","SPTBN4","MDGA1","KLF4","SCARF1","B2M","C3","RASGRF1","RAPGEF2","ATF5","NRK","C21orf91","BCL6","LYN","DTNBP1","NR4A3","EPOP","NYAP2","NRCAM","RND1","B4GALT5","CTSZ","IL6","SEMA7A","SOX8","DGKG","CAMK1D","MOV10","FARP2","NCOA1","ASCL1","UNC5C","NTN1","CXCL12","SLC4A10","NR4A2","AUTS2","STAT3","PAK1","TGIF2","RUNX1","SRC","VAX2","SEMA4A","NTNG2","ROBO1","STMN3","STMND1","CDKN1C","ISL2","MAP2","RGMA","ADGRB1","LPAR1","GPM6B","CX3CL1","CFLAR","EPHA10","GATA3","NFE2L2","SRCIN1","LIN28A","SEMA4D","NAPA","STX3","SYT17","DENND5A","PDZD7","SPTA1","SLIT2","RORB","BOC","TRIM46","NGF","C9orf72","FLOT1","ARC","MAPK8IP2","RUFY3","PLPPR4","ALDH1A2","COBL","MET","PROX1","MCF2","ADORA2A","SOX2","LIMK1","PTN","LZTS1","NPTX1","NEUROG1","WNT1","SEMA3F","BTG2"]} {"pathway":"GO_TRANSITION_METAL_ION_TRANSPORT","pval":0.68371,"padj":0.94976,"ES":0.54589,"NES":0.89461,"nMoreExtreme":53271,"size":95,"leadingEdge":["SLC31A2","LMTK2","STEAP4","FLVCR2","B2M","SCO2","SLC25A28","TCN2","ATP6V1A"]} {"pathway":"GO_CELLULAR_COMPONENT_DISASSEMBLY","pval":0.81234,"padj":0.97053,"ES":0.49405,"NES":0.89403,"nMoreExtreme":78240,"size":485,"leadingEdge":["CALCOCO2","C1QB","PLEK","ATP13A2","PADI2","OPTN","SPTBN4","C3","CTSS","SCIN","CTSL","AMER1","IL6","TNF","HPN","ATG3","TGFB1","A2M","STMN3","C1QC","UVRAG","STMND1","CAPNS2","ACTN2","CX3CL1","NAPA","SPTA1","STX17"]} {"pathway":"GO_CELL_SUBSTRATE_ADHESION","pval":0.7648,"padj":0.96082,"ES":0.50324,"NES":0.89397,"nMoreExtreme":70076,"size":291,"leadingEdge":["GBP1","LYPD5","JAK2","ITGA7","ONECUT2","VCAM1","BCL2L11","RSU1","MIR503","FAM107A","S100A10","BCL6","CSF1","PRKX","ITGAL","ITGB7","SRC","ACTN2","GPM6B","HAS2","GAS6","CX3CL1","AP1AR","SRCIN1","TECTA","SMAD3"]} {"pathway":"GO_TRANSCRIPTION_BY_RNA_POLYMERASE_I","pval":0.66368,"padj":0.94905,"ES":0.57681,"NES":0.89389,"nMoreExtreme":47799,"size":58,"leadingEdge":["TAF1A","DHX33"]} {"pathway":"GO_REGULATION_OF_CELLULAR_LOCALIZATION","pval":0.86125,"padj":0.97645,"ES":0.48978,"NES":0.89386,"nMoreExtreme":85119,"size":761,"leadingEdge":["GBP1","P2RX7","LRRK2","CXCL11","CXCL10","ATP13A2","CXCL9","GRIN3A","IFI27","CAMK2D","SIDT2","PML","SRI","ZC3H12A","CYLD","P2RX4","MCTP2","RALB","DTX3L","PMAIP1","ANK2","NUCB1","LYN","PYHIN1","DTNBP1","PARP9","EDEM1","STAC3","LILRB4","TXN","JPH4","TNF","SLC8A1","KCNE1","KMO","PAK1","SRC","TGFB1","UCP2","PTPN1","RHOQ","ACTN2","MAP2","GPM6B","PTGS2","RIPOR2","GAS6","PARL","CX3CL1","ANKRD13A","DNAJC13","BBC3","CLIC2","NADK","NAPA","SMAD3","STX3","GAS8","ZFP36","BAK1","STOM","PRR5L","FCER1G","TRIM46","SHISA7"]} {"pathway":"GO_NEUROPEPTIDE_SIGNALING_PATHWAY","pval":0.65446,"padj":0.94878,"ES":0.60577,"NES":0.89384,"nMoreExtreme":44728,"size":41,"leadingEdge":["CYSLTR2","SSTR2","ECEL1","NXPH2","RAPGEF2","SORT1"]} {"pathway":"GO_STEROID_BIOSYNTHETIC_PROCESS","pval":0.70969,"padj":0.95201,"ES":0.52623,"NES":0.89366,"nMoreExtreme":58873,"size":141,"leadingEdge":["HSD3B7","OSBPL6","HSD11B1","TNF","CH25H","CYP27B1","CES1","ERLIN1","INSIG2","PROX1","TSPOAP1"]} {"pathway":"GO_ENAMEL_MINERALIZATION","pval":0.7257,"padj":0.95562,"ES":0.70371,"NES":0.89339,"nMoreExtreme":40962,"size":10,"leadingEdge":["FAM20A","TBX1"]} {"pathway":"GO_SALIVARY_GLAND_DEVELOPMENT","pval":0.65284,"padj":0.94878,"ES":0.62946,"NES":0.89335,"nMoreExtreme":42932,"size":32,"leadingEdge":["HGF","TGM2","POLB","FGF10","TNF","TGFB1","NKX3-1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION","pval":0.65284,"padj":0.94878,"ES":0.62945,"NES":0.89334,"nMoreExtreme":42932,"size":32,"leadingEdge":["STAT1","MIR503","TNF","FLT1","CCL2","KRIT1"]} {"pathway":"GO_CYTOLYSIS_IN_OTHER_ORGANISM","pval":0.66114,"padj":0.94905,"ES":0.67009,"NES":0.89314,"nMoreExtreme":33081,"size":1,"leadingEdge":["ROMO1"]} {"pathway":"GO_VIRAL_TRANSLATIONAL_TERMINATION_REINITIATION","pval":0.63966,"padj":0.94878,"ES":0.64918,"NES":0.89299,"nMoreExtreme":33846,"size":5,"leadingEdge":["EIF3L","EIF3D","EIF3B","EIF3A","EIF3G"]} {"pathway":"GO_POSITIVE_REGULATION_OF_VIRAL_PROCESS","pval":0.6898,"padj":0.94995,"ES":0.54183,"NES":0.89296,"nMoreExtreme":54270,"size":100,"leadingEdge":["CD74","CHMP4C","CCL5","HPN","TRIM21","ADAR","STOM","GTF2B"]} {"pathway":"GO_CHEMICAL_SYNAPTIC_TRANSMISSION_POSTSYNAPTIC","pval":0.67586,"padj":0.94976,"ES":0.55933,"NES":0.89292,"nMoreExtreme":50666,"size":74,"leadingEdge":["P2RX7","LRRK2","P2RX4","MAPK8IP2","ADORA2A"]} {"pathway":"GO_ADIPOSE_TISSUE_DEVELOPMENT","pval":0.65401,"padj":0.94878,"ES":0.61958,"NES":0.89239,"nMoreExtreme":43590,"size":35,"leadingEdge":["PLAAT3","DGAT2","CSF1","AMER1","SOX8","SLC25A25","ARID5B"]} {"pathway":"GO_PROTEIN_KINASE_B_SIGNALING","pval":0.73783,"padj":0.95793,"ES":0.51199,"NES":0.89205,"nMoreExtreme":64451,"size":202,"leadingEdge":["CD40","HGF","BANK1","KLF4","CD80","P2RX4","BTN2A2","HLA-G","CCL5","NRG4","FGF10","TXN","TNF","CD86","PIK3AP1","SMPD3","CHI3L1","F3","CCL2","P2RY12","NRG2","SRC","TGFB1","ICOS","CCL19","PDGFRA","PKHD1","GAS6","CCL3","CX3CL1","GATA3","NKX3-1","LIN28A","PDGFB"]} {"pathway":"GO_STEROID_HORMONE_MEDIATED_SIGNALING_PATHWAY","pval":0.71554,"padj":0.95345,"ES":0.5238,"NES":0.89202,"nMoreExtreme":59676,"size":146,"leadingEdge":["PADI2","JAK2","PAQR8","NR4A3","HNF4G","NCOA1","NR1H3","NR4A2","PAK1","RUNX1","SRC","CREBRF","PLPP1","NKX3-1","PPARGC1B","RORB","NCOA4","ESRRB"]} {"pathway":"GO_SENSORY_PERCEPTION","pval":0.77553,"padj":0.96098,"ES":0.49997,"NES":0.89199,"nMoreExtreme":71871,"size":317,"leadingEdge":["P2RX7","KCNJ10","SPTBN4","ICAM1","RTP4","GRM8","P2RX4","MARVELD2","EDN1","CLIC5","ATXN7","HPN","SCN9A","CXCL12","PTAFR","KCNE1","CCL2","GUCA1A","VAX2","GABRR2","PTGS2","RIPOR2","CCL3","ACPP","RGS9","TECTA","PDZD7","RORB","OR2A5"]} {"pathway":"GO_TOOTH_MINERALIZATION","pval":0.71311,"padj":0.9532,"ES":0.70371,"NES":0.89172,"nMoreExtreme":41531,"size":13,"leadingEdge":["FAM20A","TBX1"]} {"pathway":"GO_CELLULAR_PROTEIN_COMPLEX_DISASSEMBLY","pval":0.74089,"padj":0.95908,"ES":0.51103,"NES":0.89078,"nMoreExtreme":64789,"size":204,"leadingEdge":["PLEK","SPTBN4","SCIN","STMN3","STMND1","ACTN2","NAPA","SPTA1"]} {"pathway":"GO_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS","pval":0.72689,"padj":0.95562,"ES":0.51825,"NES":0.89067,"nMoreExtreme":61732,"size":165,"leadingEdge":["P2RX7","PLEK","PMAIP1","DGAT2","SMPD3","PTAFR","STAT3","PTPN2","SRC","TGFB1","HAS2","PDGFB","SIK1","ESRRB","CD244"]} {"pathway":"GO_AXONAL_TRANSPORT","pval":0.66382,"padj":0.94905,"ES":0.58451,"NES":0.89066,"nMoreExtreme":46895,"size":51,"leadingEdge":["DTNBP1","MAP2","TRIM46","HAP1","PAFAH1B1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MACROPHAGE_CHEMOTAXIS","pval":0.68081,"padj":0.94976,"ES":0.66588,"NES":0.8904,"nMoreExtreme":36538,"size":6,"leadingEdge":["STAP1","SLAMF8","DDT"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS","pval":0.66891,"padj":0.94905,"ES":0.57856,"NES":0.89017,"nMoreExtreme":47753,"size":55,"leadingEdge":["CEACAM1","DGAT2","CYP27B1","ERLIN1","PDGFB","SIK1","INSIG2","PROX1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS","pval":0.72783,"padj":0.95596,"ES":0.70116,"NES":0.89014,"nMoreExtreme":41082,"size":10,"leadingEdge":["HLA-E","C3","LTA","TNF","FCER1G"]} {"pathway":"GO_EPITHELIAL_STRUCTURE_MAINTENANCE","pval":0.68939,"padj":0.94995,"ES":0.68816,"NES":0.88995,"nMoreExtreme":41659,"size":17,"leadingEdge":["NOD2","PIWIL4","TLR4"]} {"pathway":"GO_ANIMAL_ORGAN_REGENERATION","pval":0.67447,"padj":0.94976,"ES":0.56631,"NES":0.88985,"nMoreExtreme":49493,"size":65,"leadingEdge":["HGF","IGF2R","NR4A3","PTPRU","ANXA3","CXCL12","TGFB1","CDKN1A","UCP2","GAS6","BAK1"]} {"pathway":"GO_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY","pval":0.68986,"padj":0.94995,"ES":0.68762,"NES":0.88925,"nMoreExtreme":41687,"size":17,"leadingEdge":["JAK2","FAS","SMAD3","PLAUR"]} {"pathway":"GO_RESPONSE_TO_ACTIVITY","pval":0.66469,"padj":0.94905,"ES":0.58819,"NES":0.88879,"nMoreExtreme":46537,"size":48,"leadingEdge":["AGT","EDN1","SLC25A25","GCLC","PTN"]} {"pathway":"GO_POSITIVE_REGULATION_OF_VASOCONSTRICTION","pval":0.68431,"padj":0.94976,"ES":0.68242,"NES":0.88876,"nMoreExtreme":41634,"size":18,"leadingEdge":["CD38","ICAM1","PTAFR","PTGS2","TBXA2R"]} {"pathway":"GO_RESPONSE_TO_IRON_ION","pval":0.66054,"padj":0.94905,"ES":0.63599,"NES":0.88854,"nMoreExtreme":42864,"size":29,"leadingEdge":["CYP1A1","B2M","HFE"]} {"pathway":"GO_REGULATION_OF_DENDRITE_MORPHOGENESIS","pval":0.68635,"padj":0.94976,"ES":0.55252,"NES":0.88835,"nMoreExtreme":51964,"size":79,"leadingEdge":["LRRK2","RAPGEF2","SRCIN1","SEMA4D","ARC","LZTS1"]} {"pathway":"GO_SMOOTH_MUSCLE_CELL_MIGRATION","pval":0.67693,"padj":0.94976,"ES":0.56636,"NES":0.88822,"nMoreExtreme":49572,"size":64,"leadingEdge":["AGT","MIR503","CCL5","NR4A3","PAK1","SRC","LPAR1","HAS2","NFE2L2","PDGFB","SLIT2"]} {"pathway":"GO_PERK_MEDIATED_UNFOLDED_PROTEIN_RESPONSE","pval":0.67946,"padj":0.94976,"ES":0.67218,"NES":0.88741,"nMoreExtreme":42000,"size":20,"leadingEdge":["ATF3","CCL2","PTPN2","CXCL8","PTPN1","ASNS","NFE2L2","HERPUD1"]} {"pathway":"GO_SPLEEN_DEVELOPMENT","pval":0.66269,"padj":0.94905,"ES":0.64205,"NES":0.88687,"nMoreExtreme":42610,"size":27,"leadingEdge":["BCL2L11","POLB","FGF10","NFKB2","RC3H2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_T_CELL_MIGRATION","pval":0.66504,"padj":0.94905,"ES":0.64986,"NES":0.88682,"nMoreExtreme":42365,"size":25,"leadingEdge":["CXCL10","CCL5","TNFRSF14","CXCL12"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION_GABAERGIC","pval":0.70772,"padj":0.9508,"ES":0.67776,"NES":0.88656,"nMoreExtreme":38468,"size":7,"leadingEdge":["HAP1","ADORA2A","CA2"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_STIMULUS","pval":0.67072,"padj":0.94905,"ES":0.58172,"NES":0.8864,"nMoreExtreme":47383,"size":51,"leadingEdge":["VCAM1","VEGFC","EGR3","FLT1","ROBO1","PDGFRA","FOXC1","MT1G","VEGFD"]} {"pathway":"GO_STEM_CELL_DIFFERENTIATION","pval":0.7515,"padj":0.9603,"ES":0.50823,"NES":0.88626,"nMoreExtreme":65776,"size":205,"leadingEdge":["PSME2","PSMB9","PSME1","PSMB10","PSMB8","EDN1","EPOP","SEMA7A","SOX8","PSMA4","PSMA2","ASCL1","PTPRC","STAT3","RUNX1","SEMA4A","A2M","PSMA5","PDGFRA","FOXC1","GATA3","NFE2L2","LIN28A","SEMA4D"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NEURON_DIFFERENTIATION","pval":0.78585,"padj":0.96311,"ES":0.49786,"NES":0.88586,"nMoreExtreme":72296,"size":301,"leadingEdge":["HGF","AGT","SCARF1","RAPGEF2","C21orf91","BCL6","LYN","NRCAM","SEMA7A","CAMK1D","NCOA1","ASCL1","NTN1","CXCL12","PAK1","TGIF2","ROBO1","LPAR1","CX3CL1","CFLAR","NFE2L2","LIN28A","SEMA4D","SYT17","SLIT2","NGF","RUFY3","COBL","PROX1","LIMK1","PTN","NEUROG1","GDPD5","MAP6"]} {"pathway":"GO_REGULATION_OF_CELL_MATRIX_ADHESION","pval":0.70436,"padj":0.9504,"ES":0.53636,"NES":0.88554,"nMoreExtreme":55596,"size":102,"leadingEdge":["ONECUT2","FAM107A","S100A10","BCL6","CSF1","SRC","GPM6B","CX3CL1","SMAD3"]} {"pathway":"GO_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL_INVOLVED_IN_CONTRACTION","pval":0.66788,"padj":0.94905,"ES":0.6001,"NES":0.88547,"nMoreExtreme":45645,"size":41,"leadingEdge":["KCNJ2","ANK2","KCNE5","RNF207","KCNE1","KCNE1B"]} {"pathway":"GO_HORMONE_MEDIATED_SIGNALING_PATHWAY","pval":0.73853,"padj":0.95821,"ES":0.51493,"NES":0.8854,"nMoreExtreme":62812,"size":166,"leadingEdge":["RXFP1","SSTR2","PADI2","JAK2","ACSL1","PAQR8","NR4A3","HNF4G","NCOA1","NR1H3","NR4A2","PAK1","RUNX1","SRC","CREBRF","PLPP1","NKX3-1","PPARGC1B","RORB","NCOA4","ESRRB"]} {"pathway":"GO_COENZYME_A_METABOLIC_PROCESS","pval":0.6414,"padj":0.94878,"ES":0.64356,"NES":0.88527,"nMoreExtreme":33938,"size":5,"leadingEdge":["CROT","ACAT1","HMGCR","ACLY","MCCC2"]} {"pathway":"GO_PIGMENT_BIOSYNTHETIC_PROCESS","pval":0.67036,"padj":0.94905,"ES":0.58584,"NES":0.88524,"nMoreExtreme":46934,"size":48,"leadingEdge":["RAPGEF2","ALAS1","CTNS","COX10"]} {"pathway":"GO_METHIONINE_METABOLIC_PROCESS","pval":0.68209,"padj":0.94976,"ES":0.66183,"NES":0.88498,"nMoreExtreme":36607,"size":6,"leadingEdge":["MTHFR","MTHFD1"]} {"pathway":"GO_SULFUR_COMPOUND_CATABOLIC_PROCESS","pval":0.66779,"padj":0.94905,"ES":0.60884,"NES":0.88459,"nMoreExtreme":44921,"size":37,"leadingEdge":["GGT5","CHAC1","GNS","ARSB"]} {"pathway":"GO_REGULATION_OF_MYELINATION","pval":0.66576,"padj":0.94905,"ES":0.63306,"NES":0.88445,"nMoreExtreme":43203,"size":29,"leadingEdge":["HGF","TYMP","RNF10"]} {"pathway":"GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_ENDOSOME","pval":0.72472,"padj":0.95562,"ES":0.69828,"NES":0.88425,"nMoreExtreme":41803,"size":12,"leadingEdge":["DTX3L","ANKRD13A","EZR"]} {"pathway":"GO_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS","pval":0.75849,"padj":0.9603,"ES":0.50635,"NES":0.88414,"nMoreExtreme":66603,"size":210,"leadingEdge":["PLAAT3","PCYT1A","CDS1","PLSCR1","LPCAT2","PLA2G4A","FPR2","AGPAT3","MFSD2A","SLC44A2","PDGFB","RAB38","PIGY","AGAP2","LPGAT1","MTMR8"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION","pval":0.71997,"padj":0.95459,"ES":0.6977,"NES":0.88411,"nMoreExtreme":41931,"size":13,"leadingEdge":["KCNMA1","GUCY1A1","PTGS2"]} {"pathway":"GO_EPITHELIUM_DEVELOPMENT","pval":0.89508,"padj":0.98309,"ES":0.48385,"NES":0.8841,"nMoreExtreme":88797,"size":870,"leadingEdge":["IL31RA","PSME2","PSMB9","CXCL10","CEACAM1","HGF","PSME1","CHRD","STAT1","JAK2","PSMB10","AGT","ONECUT2","OVOL1","BHLHE41","PSMB8","CYP1A1","ICAM1","SIDT2","KLF4","DNAAF1","TGM2","PML","RAPGEF2","MARVELD2","EDN1","VEGFC","DHRS9","GSTK1","MAFF","CSF1","CTSL","PRKX","RNF207","CTSZ","FGF10","TNF","SOX8","CBR1","FST","PSMA4","PSMA2","DUSP10","ASCL1","NTN1","CYP27B1","SOCS3","PAK1","TRIM71","MYO1E","PODXL","RUNX1","SRC","TGFB1","ROBO1","CDKN1A","PSMA5","TXNIP","CDKN1C","CES1","FOXC1","GATA3","NKX3-1","TDRD7","RILPL1","PDGFB","SMAD3","PDZD7","ZFP36","SLIT2","HOXD11","EDNRA","PPP1R16B","HEG1","GPR161","CPT1A","SLC9A4","MTHFR","ALDH1A2","EREG","COBL","TBX1","MET","PROX1"]} {"pathway":"GO_CYCLOOXYGENASE_PATHWAY","pval":0.73151,"padj":0.95656,"ES":0.69609,"NES":0.88372,"nMoreExtreme":41290,"size":10,"leadingEdge":["CBR1","PTGS2","PTGS1"]} {"pathway":"GO_REGULATION_OF_PROTEIN_TARGETING_TO_MITOCHONDRION","pval":0.67077,"padj":0.94905,"ES":0.59872,"NES":0.88343,"nMoreExtreme":45843,"size":41,"leadingEdge":["LRRK2","PARL"]} {"pathway":"GO_CELL_PROJECTION_ORGANIZATION","pval":0.93469,"padj":0.98762,"ES":0.48227,"NES":0.88329,"nMoreExtreme":93338,"size":1270,"leadingEdge":["P2RX7","LRRK2","SNX10","CD38","PLEK","HGF","KREMEN1","EGR2","GRIN3A","JAK2","AGT","ONECUT2","GLDN","SPTBN4","ICAM1","KLF4","SCARF1","DNAAF1","LRRC61","B2M","RASGRF1","CYLD","RAPGEF2","STAP1","ENPP2","NRK","C21orf91","LYN","DTNBP1","FAM92A","CDKL1","NR4A3","NYAP2","NRCAM","B4GALT5","CTSZ","IL6","PLEKHO1","SEMA7A","CAMK1D","MOV10","FGD2","UNC5C","NTN1","CXCL12","ATG3","NR4A2","AUTS2","TUBA4A","P2RY12","PAK1","PODXL","SRC","VAX2","SEMA4A","NTNG2","CDC42EP2","ROBO1","CCL19","STMN3","STMND1","ISL2","RHOQ","ACTN2","MAP2","RGMA","ADGRB1","PKHD1","LPAR1","GPM6B","RIPOR2","NME8","CX3CL1","CFAP74","CFLAR","EPHA10","GATA3","NFE2L2","SRCIN1","SEMA4D","RILPL1","FGD6","STX3","SYT17","DENND5A","GAS8","PDZD7","SPTA1","SLIT2","BOC","TRIM46","NGF","C9orf72","PPP1R16B","FLOT1","ARC"]} {"pathway":"GO_REGULATION_OF_HORMONE_BIOSYNTHETIC_PROCESS","pval":0.67783,"padj":0.94976,"ES":0.65913,"NES":0.88245,"nMoreExtreme":42412,"size":22,"leadingEdge":["TNF","CYP27B1","DKK3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_OSSIFICATION","pval":0.69209,"padj":0.94995,"ES":0.55544,"NES":0.88222,"nMoreExtreme":51507,"size":71,"leadingEdge":["P2RX7","HGF","IFITM1","IL6","SLC8A1","TGFB1","ISG15","GPM6B","SMAD3"]} {"pathway":"GO_REGULATION_OF_VASCULAR_PERMEABILITY","pval":0.66895,"padj":0.94905,"ES":0.63139,"NES":0.88211,"nMoreExtreme":43410,"size":29,"leadingEdge":["CEACAM1","NPR1","SRC","TGFB1","SLIT2","ADORA2A"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION","pval":0.73105,"padj":0.95656,"ES":0.69639,"NES":0.88184,"nMoreExtreme":41742,"size":11,"leadingEdge":["AGT","CSF1","PRKCH"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT","pval":0.58859,"padj":0.94167,"ES":0.61924,"NES":0.88182,"nMoreExtreme":30633,"size":4,"leadingEdge":["STAT1","OSR1"]} {"pathway":"GO_REGULATION_OF_CHROMATIN_ASSEMBLY_OR_DISASSEMBLY","pval":0.72269,"padj":0.95558,"ES":0.68311,"NES":0.8817,"nMoreExtreme":39820,"size":8,"leadingEdge":["PADI2","PARP10","TPR"]} {"pathway":"GO_REGULATION_OF_GASTRULATION","pval":0.66963,"padj":0.94905,"ES":0.61783,"NES":0.88152,"nMoreExtreme":44264,"size":33,"leadingEdge":["KLF4","IL1RN","TGIF2","HNF1B"]} {"pathway":"GO_PROTEIN_CONTAINING_COMPLEX_REMODELING","pval":0.70397,"padj":0.9504,"ES":0.68618,"NES":0.88151,"nMoreExtreme":42169,"size":16,"leadingEdge":["AGT","LIPG","SCARB1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_COAGULATION","pval":0.67112,"padj":0.94905,"ES":0.61469,"NES":0.88123,"nMoreExtreme":44552,"size":34,"leadingEdge":["SERPING1","CEACAM1","EDN1","PROCR","GP1BA","PDGFRA","PDGFB"]} {"pathway":"GO_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_ACTIVITY","pval":0.67226,"padj":0.94905,"ES":0.60906,"NES":0.88116,"nMoreExtreme":45033,"size":36,"leadingEdge":["GCH1","TNF","MIR212","S100A1"]} {"pathway":"GO_FOREBRAIN_DEVELOPMENT","pval":0.79334,"padj":0.96518,"ES":0.49604,"NES":0.88101,"nMoreExtreme":72648,"size":290,"leadingEdge":["LRRK2","CHRD","SSTR2","BCL2A1","HESX1","RAPGEF2","ATF5","C21orf91","NR4A3","ANXA3","FGF10","TBX19","SEMA7A","SLC8A1","NCOA1","ASCL1","CXCL12","SLC4A10","NR4A2","AUTS2","P2RY12","SRC","VAX2","ROBO1","LPAR1","MFSD2A","PLCB1","SLIT2","PAX5","ALDH1A2","PROX1","HAP1","SOX2","PTN","WNT1","BTG2","GDPD5"]} {"pathway":"GO_AMINOPHOSPHOLIPID_TRANSPORT","pval":0.54012,"padj":0.92877,"ES":0.59793,"NES":0.88093,"nMoreExtreme":27611,"size":3,"leadingEdge":["ATP11B","TMEM30A","SCARB2"]} {"pathway":"GO_RESPONSE_TO_ETHANOL","pval":0.70651,"padj":0.9508,"ES":0.54237,"NES":0.88084,"nMoreExtreme":54292,"size":87,"leadingEdge":["GRIN3A","CCL7","VCAM1","ICAM1","POLB","STAT3","GATA3","BAK1","KCNMB1"]} {"pathway":"GO_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION","pval":0.67175,"padj":0.94905,"ES":0.62384,"NES":0.88062,"nMoreExtreme":43975,"size":31,"leadingEdge":["CHRD","STAT1","TBX1","PTN","SIX1"]} {"pathway":"GO_REGULATION_OF_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY","pval":0.68734,"padj":0.94995,"ES":0.66688,"NES":0.88043,"nMoreExtreme":42487,"size":20,"leadingEdge":["F3","PTPN2","SRC","NDRG4"]} {"pathway":"GO_TISSUE_HOMEOSTASIS","pval":0.74397,"padj":0.95959,"ES":0.515,"NES":0.88018,"nMoreExtreme":62482,"size":153,"leadingEdge":["P2RX7","SNX10","CD38","NOD2","FLT3LG","B2M","P2RX4","PIWIL4","CSF1","IL7","TNFAIP3","IL6","SRC","PRDX1","FOXC1","PPARGC1B"]} {"pathway":"GO_RESPONSE_TO_ELECTRICAL_STIMULUS","pval":0.67333,"padj":0.94976,"ES":0.64481,"NES":0.87993,"nMoreExtreme":42893,"size":25,"leadingEdge":["P2RX7","S100A13","SRC","BTG2"]} {"pathway":"GO_LOCOMOTORY_BEHAVIOR","pval":0.73437,"padj":0.95787,"ES":0.51977,"NES":0.87977,"nMoreExtreme":60521,"size":135,"leadingEdge":["IDO1","LRRK2","KCNJ10","SPTBN4","CTNS","CXCL12","SLC4A10","NR4A2","ASTN1","SEZ6L"]} {"pathway":"GO_RESPONSE_TO_ANGIOTENSIN","pval":0.67812,"padj":0.94976,"ES":0.65272,"NES":0.8796,"nMoreExtreme":42665,"size":23,"leadingEdge":["AGT","SRC","ACTN2","PTGS2","AGTRAP","NFE2L2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS","pval":0.67838,"padj":0.94976,"ES":0.59557,"NES":0.87878,"nMoreExtreme":46363,"size":41,"leadingEdge":["HGF","PTAFR","RNF10"]} {"pathway":"GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION","pval":0.74621,"padj":0.96025,"ES":0.51451,"NES":0.8785,"nMoreExtreme":62542,"size":151,"leadingEdge":["NOD2","VEGFC","MIR503","DYSF","GLUL","NR4A3","TNFAIP3","FGF10","EGR3","STAT5A","HPN","CXCL12","F3","STAT3","TGFB1","HAS2","CFLAR","PDGFB","PPP1R16B","TBX1","PROX1","PTN"]} {"pathway":"GO_ICOSANOID_BIOSYNTHETIC_PROCESS","pval":0.67388,"padj":0.94976,"ES":0.63212,"NES":0.87844,"nMoreExtreme":43530,"size":28,"leadingEdge":["CD74","EDN1","CBR1","PLA2G4A","PTGS2"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_ALCOHOL","pval":0.70069,"padj":0.94995,"ES":0.55103,"NES":0.87833,"nMoreExtreme":52408,"size":73,"leadingEdge":["CCL7","XRN1","KLF4","GRAMD1B","PTGER4","PTGER2","KCNMB1"]} {"pathway":"GO_GLOMERULAR_MESANGIAL_CELL_PROLIFERATION","pval":0.73153,"padj":0.95656,"ES":0.68751,"NES":0.87816,"nMoreExtreme":40880,"size":9,"leadingEdge":["CFLAR","PDGFB","PDGFRB"]} {"pathway":"GO_CEREBRAL_CORTEX_NEURON_DIFFERENTIATION","pval":0.71944,"padj":0.95459,"ES":0.68983,"NES":0.87788,"nMoreExtreme":42346,"size":14,"leadingEdge":["C21orf91","ASCL1","GDPD5","PAFAH1B1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS","pval":0.67982,"padj":0.94976,"ES":0.5968,"NES":0.87767,"nMoreExtreme":46339,"size":40,"leadingEdge":["B2M","C3","CCL19","SELE"]} {"pathway":"GO_MONOTERPENOID_METABOLIC_PROCESS","pval":0.55662,"padj":0.93517,"ES":0.58835,"NES":0.87756,"nMoreExtreme":27971,"size":2,"leadingEdge":["CYP2D6","CYP1A2"]} {"pathway":"GO_B_CELL_LINEAGE_COMMITMENT","pval":0.58969,"padj":0.94209,"ES":0.61592,"NES":0.87709,"nMoreExtreme":30690,"size":4,"leadingEdge":["SLAMF8","TCF3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS","pval":0.71564,"padj":0.95345,"ES":0.53565,"NES":0.87702,"nMoreExtreme":55698,"size":94,"leadingEdge":["DTX3L","PMAIP1","PYHIN1","PARP3","PARP9","FGF10","NKX3-1","HIC1"]} {"pathway":"GO_MITOCHONDRIAL_TRANSPORT","pval":0.78485,"padj":0.96311,"ES":0.4988,"NES":0.87623,"nMoreExtreme":69963,"size":234,"leadingEdge":["LRRK2","BCL2L11","PMAIP1","SLC25A28","SLC25A22","PSEN2","STAT3","UCP2","PARL","BBC3","BAK1","SLC25A30","CPT1A"]} {"pathway":"GO_REGULATION_OF_ORGANIC_ACID_TRANSPORT","pval":0.68146,"padj":0.94976,"ES":0.60025,"NES":0.8758,"nMoreExtreme":46078,"size":38,"leadingEdge":["P2RX7","AGT","P2RX4","EDN1","KMO","ADORA2A"]} {"pathway":"GO_BLOOD_VESSEL_ENDOTHELIAL_CELL_PROLIFERATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS","pval":0.69807,"padj":0.94995,"ES":0.67245,"NES":0.87576,"nMoreExtreme":42471,"size":18,"leadingEdge":["MIR503","PPP1R16B","NGFR"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TRANSFERASE_ACTIVITY","pval":0.86718,"padj":0.97662,"ES":0.4823,"NES":0.87558,"nMoreExtreme":84344,"size":561,"leadingEdge":["CD40","CD74","P2RX7","SOCS1","LRRK2","NOD2","HGF","JAK2","AGT","RIPK2","ACSL1","KLF4","FAM20A","RAPGEF2","STAP1","RALB","EDN1","NCF1","DTX3L","NRK","GADD45B","CCL5","LYN","CSF1","TLR3","FGF10","TXN","GADD45G","TNF","FLT1","RASGRP1","FGD2","LCP2","PTPRC","CHI3L1","FPR2","NBN","P2RY12","PAK1","SRC","TGFB1","ROBO1","CCL19","CDKN1A","PDGFRA","DUSP5","PTPN1","LPAR1","GAS6","TCIM","BIRC7","SRCIN1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_T_HELPER_1_TYPE_IMMUNE_RESPONSE","pval":0.70391,"padj":0.9504,"ES":0.67698,"NES":0.87549,"nMoreExtreme":42536,"size":17,"leadingEdge":["IL12RB1","RIPK2","CD80","CCL19","HLX"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION","pval":0.682,"padj":0.94976,"ES":0.60242,"NES":0.87525,"nMoreExtreme":45877,"size":37,"leadingEdge":["CHRD","TNF","SEMA4D","SMAD3","RORB","HDAC4"]} {"pathway":"GO_CELLULAR_DETOXIFICATION","pval":0.70759,"padj":0.9508,"ES":0.54671,"NES":0.87518,"nMoreExtreme":53235,"size":76,"leadingEdge":["GCH1","GSTK1","SOD2","TXN","TNF","PRDX1","PTGS2","NFE2L2","CLIC2"]} {"pathway":"GO_REGULATION_OF_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_BETA_SIGNALING_PATHWAY","pval":0.7252,"padj":0.95562,"ES":0.67806,"NES":0.87518,"nMoreExtreme":39958,"size":8,"leadingEdge":["PTPN2","SRC","LOX"]} {"pathway":"GO_CARBOHYDRATE_CATABOLIC_PROCESS","pval":0.75389,"padj":0.9603,"ES":0.5123,"NES":0.87509,"nMoreExtreme":63240,"size":152,"leadingEdge":["P2RX7","GK","PFKP","STAT3","GM2A","GPD2","FUT4","ESRRB","GALM","STBD1","HDAC4","FUT1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION","pval":0.68065,"padj":0.94976,"ES":0.64107,"NES":0.87482,"nMoreExtreme":43359,"size":25,"leadingEdge":["ENPP2","AUTS2","SRC","WNT1","HDAC4"]} {"pathway":"GO_ODONTOGENESIS_OF_DENTIN_CONTAINING_TOOTH","pval":0.69822,"padj":0.94995,"ES":0.56088,"NES":0.87468,"nMoreExtreme":50743,"size":61,"leadingEdge":["BCL2L11","FAM20A","CSF1","FGF10","SMPD3","PDGFRA","FOXC1","TBX1"]} {"pathway":"GO_AORTIC_VALVE_DEVELOPMENT","pval":0.67916,"padj":0.94976,"ES":0.6331,"NES":0.8745,"nMoreExtreme":43669,"size":27,"leadingEdge":["TGFB1","ROBO1","GATA3","SLIT2","SNAI2"]} {"pathway":"GO_SNARE_COMPLEX_ASSEMBLY","pval":0.705,"padj":0.9508,"ES":0.67606,"NES":0.8743,"nMoreExtreme":42602,"size":17,"leadingEdge":["PRRT2","TRIM9","UVRAG","VPS41"]} {"pathway":"GO_REGULATION_OF_POSTSYNAPTIC_MEMBRANE_POTENTIAL","pval":0.72098,"padj":0.95459,"ES":0.53593,"NES":0.87419,"nMoreExtreme":55741,"size":91,"leadingEdge":["P2RX7","LRRK2","GRIN3A","P2RX4","SLC8A1","RGS7BP","GABRR2"]} {"pathway":"GO_FEEDING_BEHAVIOR","pval":0.68627,"padj":0.94976,"ES":0.58813,"NES":0.87414,"nMoreExtreme":47254,"size":43,"leadingEdge":["AGT","NR4A3","ADM2","STAT3","GLS","CPT1A","ADORA2A"]} {"pathway":"GO_HEART_VALVE_DEVELOPMENT","pval":0.69364,"padj":0.94995,"ES":0.57229,"NES":0.87393,"nMoreExtreme":49106,"size":52,"leadingEdge":["NOTCH2","TGFB1","ROBO1","GATA3","SLIT2","SNAI2"]} {"pathway":"GO_AMINE_TRANSPORT","pval":0.69496,"padj":0.94995,"ES":0.57023,"NES":0.87325,"nMoreExtreme":49345,"size":53,"leadingEdge":["P2RX7","AGT","SLC18A1","DTNBP1","CXCL12","KMO","P2RY12","SYT5","SYT17"]} {"pathway":"GO_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS","pval":0.68996,"padj":0.94995,"ES":0.6521,"NES":0.87304,"nMoreExtreme":43171,"size":22,"leadingEdge":["TYMP","TIFAB","FGF10","NR1H3","NEUROG1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_DNA_RECOMBINATION","pval":0.68603,"padj":0.94976,"ES":0.59826,"NES":0.8729,"nMoreExtreme":46387,"size":38,"leadingEdge":["CD40","TBX21","PTPRC","TGFB1"]} {"pathway":"GO_REGULATION_OF_GLOMERULUS_DEVELOPMENT","pval":0.73817,"padj":0.95809,"ES":0.68751,"NES":0.87281,"nMoreExtreme":41666,"size":10,"leadingEdge":["CFLAR","PDGFB","EGR1"]} {"pathway":"GO_OSTEOCLAST_DIFFERENTIATION","pval":0.71501,"padj":0.95345,"ES":0.5421,"NES":0.87275,"nMoreExtreme":54258,"size":80,"leadingEdge":["SNX10","LILRB3","SBNO2","CSF1","TLR3","LILRB4","NOTCH2","TNF","FARP2","LILRB1","SRC","TGFB1","OCSTAMP","CCL3","PPARGC1B","FCER1G","TLR4","CCR1"]} {"pathway":"GO_THYROID_HORMONE_METABOLIC_PROCESS","pval":0.73835,"padj":0.95815,"ES":0.68729,"NES":0.87254,"nMoreExtreme":41676,"size":10,"leadingEdge":["HPN","GATA3","TG"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION","pval":0.70169,"padj":0.94995,"ES":0.66997,"NES":0.87253,"nMoreExtreme":42691,"size":18,"leadingEdge":["FAM107A","SRC","CORO1C"]} {"pathway":"GO_DIACYLGLYCEROL_METABOLIC_PROCESS","pval":0.7336,"padj":0.95773,"ES":0.68901,"NES":0.8725,"nMoreExtreme":42315,"size":12,"leadingEdge":["DGAT2","DGKG","DGKA"]} {"pathway":"GO_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION","pval":0.72796,"padj":0.95596,"ES":0.53109,"NES":0.87221,"nMoreExtreme":56897,"size":97,"leadingEdge":["HGF","CHRD","IFITM1","IL6","TNF","SEMA4D","SMAD3","RORB"]} {"pathway":"GO_POSITIVE_REGULATION_OF_RESPONSE_TO_WOUNDING","pval":0.69081,"padj":0.94995,"ES":0.58055,"NES":0.87206,"nMoreExtreme":48082,"size":46,"leadingEdge":["PLEK","SCARF1","ENPP4","F3","NFE2L2","TLR4"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_MIGRATION","pval":0.68475,"padj":0.94976,"ES":0.60539,"NES":0.87195,"nMoreExtreme":45639,"size":35,"leadingEdge":["PADI2","STAP1","SLAMF8","PTGER4","GPR18","CXCL12","CCL2","RIPOR2","IL33","PLCB1","SLIT2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_DNA_METABOLIC_PROCESS","pval":0.75716,"padj":0.9603,"ES":0.51163,"NES":0.87173,"nMoreExtreme":63212,"size":147,"leadingEdge":["CD40","TBX21","PML","DTX3L","PARP3","PARP9","ANXA3","FGF10","PTPRC","NBN","TGFB1","OTUD4"]} {"pathway":"GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_MEMBRANE_REPOLARIZATION","pval":0.69165,"padj":0.94995,"ES":0.65104,"NES":0.87162,"nMoreExtreme":43277,"size":22,"leadingEdge":["ANK2","KCNE5","RNF207","KCNE1","KCNE1B"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION","pval":0.71687,"padj":0.95386,"ES":0.54202,"NES":0.87146,"nMoreExtreme":54275,"size":79,"leadingEdge":["STAT1","JAK2","AGT","TGM2","EDN1","CCL5","NR4A3","IL6","TNF","SMPD3","PTAFR","PAK1","NAMPT","PTGS2","CX3CL1","PDGFB"]} {"pathway":"GO_THYMIC_T_CELL_SELECTION","pval":0.72023,"padj":0.95459,"ES":0.68193,"NES":0.87126,"nMoreExtreme":42797,"size":15,"leadingEdge":["CD74","PTPRC","PTPN2","GATA3"]} {"pathway":"GO_GLOMERULAR_MESANGIUM_DEVELOPMENT","pval":0.73043,"padj":0.95646,"ES":0.68749,"NES":0.87118,"nMoreExtreme":42540,"size":13,"leadingEdge":["CFLAR","PDGFB","ACTA2"]} {"pathway":"GO_REGULATION_OF_MITOTIC_SPINDLE_ASSEMBLY","pval":0.69789,"padj":0.94995,"ES":0.65967,"NES":0.8709,"nMoreExtreme":43139,"size":20,"leadingEdge":["CHMP4C","TPR"]} {"pathway":"GO_PROTEIN_STABILIZATION","pval":0.76117,"padj":0.96082,"ES":0.50998,"NES":0.87077,"nMoreExtreme":63796,"size":151,"leadingEdge":["ATP1B2","ANK2","PYHIN1","CDKN1A","SMAD3","FLOT1"]} {"pathway":"GO_SOMATIC_STEM_CELL_POPULATION_MAINTENANCE","pval":0.70176,"padj":0.94995,"ES":0.56579,"NES":0.87051,"nMoreExtreme":50098,"size":55,"leadingEdge":["ASCL2","KLF4","FGF10","STAT3","LIG4","LIN28A","SOX2","HNF1B"]} {"pathway":"GO_POSITIVE_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL","pval":0.6858,"padj":0.94976,"ES":0.61333,"NES":0.87046,"nMoreExtreme":45099,"size":32,"leadingEdge":["CXCL11","CXCL10","CXCL9","SRI","CX3CL1"]} {"pathway":"GO_ALPHA_AMINO_ACID_BIOSYNTHETIC_PROCESS","pval":0.70056,"padj":0.94995,"ES":0.56954,"NES":0.86973,"nMoreExtreme":49596,"size":52,"leadingEdge":["GGT5","GLUL","ASNS","GLS","SEPHS2","ASS1","MTHFR","CBSL","AASS"]} {"pathway":"GO_MITOCHONDRIAL_GENOME_MAINTENANCE","pval":0.69999,"padj":0.94995,"ES":0.65841,"NES":0.86924,"nMoreExtreme":43269,"size":20,"leadingEdge":["TYMP","LIG3"]} {"pathway":"GO_PROSTATE_GLAND_DEVELOPMENT","pval":0.69314,"padj":0.94995,"ES":0.59069,"NES":0.86869,"nMoreExtreme":47247,"size":40,"leadingEdge":["FGF10","NKX3-1","FKBP4"]} {"pathway":"GO_BASE_EXCISION_REPAIR_GAP_FILLING","pval":0.64561,"padj":0.94878,"ES":0.63087,"NES":0.86781,"nMoreExtreme":34161,"size":5,"leadingEdge":["POLB","POLD1"]} {"pathway":"GO_COLLAGEN_CATABOLIC_PROCESS","pval":0.69249,"padj":0.94995,"ES":0.59972,"NES":0.86765,"nMoreExtreme":46388,"size":36,"leadingEdge":["CTSS","MMP25","CTSL","FAP"]} {"pathway":"GO_HETEROPHILIC_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES","pval":0.68986,"padj":0.94995,"ES":0.61131,"NES":0.86759,"nMoreExtreme":45366,"size":32,"leadingEdge":["VCAM1","ICAM1","ITGAL","SELE"]} {"pathway":"GO_TISSUE_REMODELING","pval":0.754,"padj":0.9603,"ES":0.51541,"NES":0.8675,"nMoreExtreme":61506,"size":126,"leadingEdge":["P2RX7","SNX10","CD38","IL15","CEACAM1","AGT","TGM2","IL7","TNFAIP3","IL6","FGF10","NOTCH2","SRC","TGFB1","FOXC1","PPARGC1B","BAK1","IL1A"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS","pval":0.72912,"padj":0.95596,"ES":0.6815,"NES":0.86728,"nMoreExtreme":42916,"size":14,"leadingEdge":["LRRK2","GPR35"]} {"pathway":"GO_REGULATION_OF_TRANSMISSION_OF_NERVE_IMPULSE","pval":0.72879,"padj":0.95596,"ES":0.67185,"NES":0.86717,"nMoreExtreme":40156,"size":8,"leadingEdge":["AGT","TYMP","GPR35"]} {"pathway":"GO_RECEPTOR_MEDIATED_ENDOCYTOSIS","pval":0.80466,"padj":0.96677,"ES":0.49338,"NES":0.86714,"nMoreExtreme":71804,"size":236,"leadingEdge":["APOL1","CEACAM1","CLEC9A","SCARF1","B2M","C3","LGALS3BP","ENPP2","IGF2R","CXCL16","FCHO1","LILRB1","FPR2","ACKR4","FCGR1A","CCL19","CXCL8","AMN","FCGR1B","ANKRD13A","DNAJC13","ILDR1","FCER1G","FLOT1","ARC"]} {"pathway":"GO_ALKALOID_METABOLIC_PROCESS","pval":0.54605,"padj":0.93112,"ES":0.58838,"NES":0.86686,"nMoreExtreme":27914,"size":3,"leadingEdge":["CYP2D6","BCHE","CYP1A2"]} {"pathway":"GO_DEFENSE_RESPONSE_TO_GRAM_NEGATIVE_BACTERIUM","pval":0.68957,"padj":0.94995,"ES":0.62032,"NES":0.86665,"nMoreExtreme":44748,"size":29,"leadingEdge":["OPTN","GSDMD","TNFRSF14","IL6","MR1","ADGRB1","TLR4"]} {"pathway":"GO_DNA_METHYLATION","pval":0.70146,"padj":0.94995,"ES":0.57351,"NES":0.86661,"nMoreExtreme":49112,"size":48,"leadingEdge":["PIWIL4","TDRD9","KDM1B","KMT2E"]} {"pathway":"GO_BLOOD_VESSEL_MORPHOGENESIS","pval":0.87165,"padj":0.97717,"ES":0.47864,"NES":0.86627,"nMoreExtreme":83985,"size":487,"leadingEdge":["CD40","CXCL10","CEACAM1","TNFAIP2","AMOT","HGF","STAT1","AGT","TYMP","KLF4","PML","C3","ZC3H12A","RAPGEF2","NPR1","ENPP2","EDN1","VEGFC","MIR503","SAT1","COMP","DYSF","HLA-G","GLUL","NRCAM","PRKX","TNFAIP3","ANXA3","IL6","TLR3","FGF10","EGR3","FLT1","ADM2","CHI3L1","F3","CCL2","STAT3","MYO1E","ANGPTL4","RUNX1","TGFB1","SEMA4A","ROBO1","CXCL8","PDGFRA","ADGRB1","PTGS2","HAS2","CX3CL1","FOXC1","ESM1","NFE2L2","MIR212","ERAP1","SLIT2","BAK1","IL1A","EDNRA","COL8A2","PPP1R16B","S100A1","HEG1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELL_FATE_COMMITMENT","pval":0.72939,"padj":0.95596,"ES":0.671,"NES":0.86607,"nMoreExtreme":40189,"size":8,"leadingEdge":["TBX21","DKK1"]} {"pathway":"GO_CARDIOVASCULAR_SYSTEM_DEVELOPMENT","pval":0.89108,"padj":0.9819,"ES":0.47651,"NES":0.86599,"nMoreExtreme":86944,"size":591,"leadingEdge":["CD40","CXCL10","CEACAM1","TNFAIP2","AMOT","HGF","STAT1","AGT","TYMP","KLF4","PML","C3","ZC3H12A","RAPGEF2","NPR1","ENPP2","EDN1","VEGFC","MIR503","SAT1","COMP","DYSF","HLA-G","GLUL","NRCAM","SOD2","PRKX","TNFAIP3","ANXA3","IL6","TLR3","FGF10","EGR3","FLT1","ADM2","CHI3L1","F3","SOCS3","CCL2","STAT3","MYO1E","ANGPTL4","RUNX1","TGFB1","SEMA4A","ROBO1","CXCL8","PDGFRA","ADGRB1","PTGS2","HAS2","CX3CL1","FOXC1","CFLAR","ESM1","NKX3-1","NFE2L2","MIR212","ERAP1","PDGFB","SLIT2","BAK1","IL1A","EDNRA","COL8A2","PPP1R16B","S100A1","HEG1"]} {"pathway":"GO_LYMPH_NODE_DEVELOPMENT","pval":0.72512,"padj":0.95562,"ES":0.67776,"NES":0.86594,"nMoreExtreme":43088,"size":15,"leadingEdge":["IL15","POLB","LTA","LTB","TGFB1"]} {"pathway":"GO_FOREBRAIN_NEURON_DIFFERENTIATION","pval":0.69445,"padj":0.94995,"ES":0.6036,"NES":0.86533,"nMoreExtreme":46101,"size":34,"leadingEdge":["RAPGEF2","ATF5","ASCL1","SLC4A10","AUTS2","ROBO1","SLIT2","PROX1"]} {"pathway":"GO_REGULATION_OF_DNA_METABOLIC_PROCESS","pval":0.81607,"padj":0.971,"ES":0.49004,"NES":0.86452,"nMoreExtreme":73542,"size":253,"leadingEdge":["CD40","TBX21","XRN1","RMI2","PML","DTX3L","BCL6","PARP3","PARP9","ANXA3","FGF10","PTPRC","NBN","SRC","TGFB1","CGAS","HELB","STN1","OTUD4","GATA3"]} {"pathway":"GO_RESPONSE_TO_GROWTH_FACTOR","pval":0.89026,"padj":0.98144,"ES":0.47602,"NES":0.86451,"nMoreExtreme":86672,"size":571,"leadingEdge":["HGF","CHRD","AGT","MYOF","ONECUT2","VCAM1","KLF4","PML","RAPGEF2","EDN1","VEGFC","MIR503","COMP","CCL5","GAREM1","ANXA3","FGF10","EGR3","HTRA4","CHST11","FLT1","SMPD3","ASCL1","CCL2","TRIM71","GCLC","SRC","TGFB1","ROBO1","CXCL8","PDGFRA","CDKN1C","PTPN1","SORT1","RGMA","EGR4","HAS2","GAS6","FOXC1","CFLAR","GATA3","MT1G","MIR212","PDGFB","SMAD3","ZFP36","SLIT2"]} {"pathway":"GO_ATP_METABOLIC_PROCESS","pval":0.69765,"padj":0.94995,"ES":0.59737,"NES":0.86425,"nMoreExtreme":46734,"size":36,"leadingEdge":["CTNS","MYH7","SLC25A25","ATP6V1A","AK4","NADK","BAD"]} {"pathway":"GO_POSITIVE_REGULATION_OF_GLIOGENESIS","pval":0.71559,"padj":0.95345,"ES":0.5549,"NES":0.86359,"nMoreExtreme":51869,"size":60,"leadingEdge":["P2RX4","LYN","CSF1","LTA","IL6","TNF","SOX8","P2RY12","TGFB1","CCL3"]} {"pathway":"GO_PROTEIN_ACTIVATION_CASCADE","pval":0.74091,"padj":0.95908,"ES":0.68181,"NES":0.86339,"nMoreExtreme":42737,"size":12,"leadingEdge":["SERPING1","F3","A2M","GP1BA"]} {"pathway":"GO_POSITIVE_REGULATION_OF_GLIAL_CELL_MIGRATION","pval":0.7436,"padj":0.95959,"ES":0.68005,"NES":0.86335,"nMoreExtreme":41972,"size":10,"leadingEdge":["P2RX4","CSF1","P2RY12","CCL3"]} {"pathway":"GO_HISTONE_H4_K5_ACETYLATION","pval":0.72192,"padj":0.95512,"ES":0.67202,"NES":0.86332,"nMoreExtreme":43244,"size":16,"leadingEdge":["JADE2","PHF20"]} {"pathway":"GO_SULFATION","pval":0.74103,"padj":0.95908,"ES":0.68166,"NES":0.86321,"nMoreExtreme":42744,"size":12,"leadingEdge":["SULT1C2","HS3ST3B1","NDST1"]} {"pathway":"GO_NEGATIVE_T_CELL_SELECTION","pval":0.73075,"padj":0.95656,"ES":0.66865,"NES":0.86303,"nMoreExtreme":40264,"size":8,"leadingEdge":["CD74","PTPRC","ATG5"]} {"pathway":"GO_MACROPHAGE_CHEMOTAXIS","pval":0.69473,"padj":0.94995,"ES":0.62099,"NES":0.86298,"nMoreExtreme":44877,"size":28,"leadingEdge":["STAP1","SLAMF8","CCL5","CSF1","CCL2","CCL3","CX3CL1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_FIBROBLAST_PROLIFERATION","pval":0.70692,"padj":0.9508,"ES":0.57105,"NES":0.86289,"nMoreExtreme":49494,"size":48,"leadingEdge":["CD74","AGT","PML","FGF10","TGFB1","CDKN1A","PDGFRA","LIG4","GAS6","PDGFB","EREG","WNT1"]} {"pathway":"GO_RESPONSE_TO_CADMIUM_ION","pval":0.70993,"padj":0.95201,"ES":0.56618,"NES":0.86272,"nMoreExtreme":50153,"size":51,"leadingEdge":["B2M","NCF1","MT2A","MT1M","MT1E","GCLC","MT1H","MT1G","NPC1","MTF1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_DNA_RECOMBINATION","pval":0.69776,"padj":0.94995,"ES":0.61086,"NES":0.8623,"nMoreExtreme":45678,"size":31,"leadingEdge":["RMI2","BCL6","PARP3","CGAS","HELB"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION","pval":0.74959,"padj":0.9603,"ES":0.52176,"NES":0.86223,"nMoreExtreme":59247,"size":103,"leadingEdge":["CEACAM1","STAT1","MIR503","TNF","FLT1","HPN","DUSP10","CCL2","TGFB1","ROBO1","CDKN1C","GATA3","NKX3-1","EREG","SOX2","PTN"]} {"pathway":"GO_DORSAL_VENTRAL_PATTERN_FORMATION","pval":0.71714,"padj":0.95386,"ES":0.55781,"NES":0.86213,"nMoreExtreme":51451,"size":57,"leadingEdge":["CHRD","EDN1","ASCL1","VAX2","HOXD11","GPR161"]} {"pathway":"GO_EMBRYONIC_DIGIT_MORPHOGENESIS","pval":0.71152,"padj":0.95246,"ES":0.56556,"NES":0.86177,"nMoreExtreme":50265,"size":51,"leadingEdge":["BCL2L11","CHST11","HOXA11"]} {"pathway":"GO_EXECUTION_PHASE_OF_APOPTOSIS","pval":0.72091,"padj":0.95459,"ES":0.55162,"NES":0.86172,"nMoreExtreme":52505,"size":62,"leadingEdge":["ZC3H12A","CASP7","XKR6","CASP10","XKR8","XKR7","CASP1","BBC3","CECR2"]} {"pathway":"GO_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS","pval":0.71695,"padj":0.95386,"ES":0.55894,"NES":0.86168,"nMoreExtreme":51291,"size":56,"leadingEdge":["SOCS1","AGT","CISH","TRIM72","SOCS3","PTPN2","PAK1","SRC","PTPN1"]} {"pathway":"GO_REGULATION_OF_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY","pval":0.69798,"padj":0.94995,"ES":0.6311,"NES":0.86122,"nMoreExtreme":44463,"size":25,"leadingEdge":["MIR503","GATA3","SHISA2","FUZ"]} {"pathway":"GO_LEUKOCYTE_TETHERING_OR_ROLLING","pval":0.7115,"padj":0.95246,"ES":0.65647,"NES":0.86081,"nMoreExtreme":43698,"size":19,"leadingEdge":["SELL","VCAM1","TNF","CXCL12","PTAFR","ITGB7","GCNT1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_FC_RECEPTOR_MEDIATED_STIMULATORY_SIGNALING_PATHWAY","pval":0.71716,"padj":0.95386,"ES":0.65805,"NES":0.86078,"nMoreExtreme":38981,"size":7,"leadingEdge":["LYN","CD226","PTPRC"]} {"pathway":"GO_ANATOMICAL_STRUCTURE_FORMATION_INVOLVED_IN_MORPHOGENESIS","pval":0.93308,"padj":0.98762,"ES":0.471,"NES":0.86053,"nMoreExtreme":92547,"size":860,"leadingEdge":["CD40","CXCL10","CEACAM1","TNFAIP2","AMOT","HGF","CXCL9","CHRD","EGR2","STAT1","AGT","PIM1","ITGA7","MYOF","TNFSF13B","BHLHE41","TYMP","KLF4","BCL2L11","TGM2","FLT3LG","PML","FAM20A","C3","ZC3H12A","NPR1","ENPP2","EDN1","VEGFC","MIR503","SAT1","SBNO2","ANK2","DYSF","HLA-G","BCL6","TIFAB","GLUL","NR4A3","NRCAM","PRKX","TNFAIP3","ANXA3","IL6","TLR3","FGF10","PLEKHO1","EGR3","NFKB2","TNF","SOX8","FLT1","ADM2","HOPX","SMPD3","CHI3L1","F3","CCL2","STAT3","TRIM71","ANGPTL4","PODXL","RUNX1","TGFB1","SEMA4A","OCSTAMP","ROBO1","CXCL8","PDGFRA","ACTN2","ADGRB1","PTGS2","RIPOR2","CX3CL1","FOXC1","CFLAR","ESM1","GATA3","NKX3-1","NFE2L2","PPARGC1B","MIR212","CD53","ERAP1"]} {"pathway":"GO_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY","pval":0.87653,"padj":0.9791,"ES":0.4762,"NES":0.85983,"nMoreExtreme":83879,"size":445,"leadingEdge":["CD40","CD74","P2RX7","LRRK2","NOD2","HGF","JAK2","RIPK2","ACSL1","FAM20A","RAPGEF2","RALB","EDN1","NRK","GADD45B","LYN","DTNBP1","TNFAIP3","FGF10","GADD45G","TNF","FLT1","DUSP10","RASGRP1","FGD2","PTPRC","PAK1","SRC","TGFB1","ROBO1","CCL19","CDKN1A","UVRAG","DUSP5","CDKN1C","PTPN1","CCNL1","LPAR1","TCIM","BIRC7","CCNA1","PDGFB"]} {"pathway":"GO_CELL_GROWTH","pval":0.86461,"padj":0.97662,"ES":0.47791,"NES":0.85974,"nMoreExtreme":81912,"size":393,"leadingEdge":["CD38","CEACAM1","AGT","CAMK2D","PML","NPR1","EDN1","FAM107A","CISH","BCL6","NRCAM","CXCL16","SEMA7A","HPN","NTN1","CXCL12","CYP27B1","AUTS2","PAK1","TGFB1","SEMA4A","CDKN1A","OGFR","MAP2","SEMA4D","SMAD3","SYT17","SLIT2","TRIM46","NGF","C9orf72","ARHGEF11","RUFY3","COBL","CLSTN3","LIMK1"]} {"pathway":"GO_SKELETAL_MUSCLE_ORGAN_DEVELOPMENT","pval":0.77196,"padj":0.96084,"ES":0.50905,"NES":0.85903,"nMoreExtreme":63256,"size":130,"leadingEdge":["VAMP5","EGR2","ATF3","MAFF","ASB2","STAC3","SOX8","IGSF8","TGFB1","RIPOR2","CFLAR","NUPR1","MYOZ1","FOXN2","PAX5","HLX","FLOT1","ASS1","TBX1","BTG2","HDAC4"]} {"pathway":"GO_VOCALIZATION_BEHAVIOR","pval":0.73609,"padj":0.95787,"ES":0.67483,"NES":0.85878,"nMoreExtreme":43326,"size":14,"leadingEdge":["TIFAB","AUTS2","NEUROG1","NRXN3"]} {"pathway":"GO_PROTEIN_SULFATION","pval":0.64794,"padj":0.94878,"ES":0.62399,"NES":0.85835,"nMoreExtreme":34284,"size":5,"leadingEdge":["HS3ST3B1","NDST1"]} {"pathway":"GO_SPECIFICATION_OF_ANIMAL_ORGAN_IDENTITY","pval":0.70189,"padj":0.94996,"ES":0.62478,"NES":0.85778,"nMoreExtreme":44908,"size":26,"leadingEdge":["FGF10","ROBO1","SMARCD3","SIX1","HOXA11"]} {"pathway":"GO_TUBE_LUMEN_CAVITATION","pval":0.55062,"padj":0.93215,"ES":0.58211,"NES":0.85761,"nMoreExtreme":28148,"size":3,"leadingEdge":["TGM2","NFIB"]} {"pathway":"GO_GAP_JUNCTION_ASSEMBLY","pval":0.74189,"padj":0.95912,"ES":0.67127,"NES":0.85742,"nMoreExtreme":41459,"size":9,"leadingEdge":["AGT","GJD3","CTNNA1"]} {"pathway":"GO_REGULATION_OF_TELOMERE_MAINTENANCE","pval":0.74019,"padj":0.95908,"ES":0.53472,"NES":0.85706,"nMoreExtreme":55774,"size":77,"leadingEdge":["XRN1","PML","NBN","SRC","STN1","PRKCQ"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_1_PRODUCTION","pval":0.70592,"padj":0.9508,"ES":0.63592,"NES":0.85695,"nMoreExtreme":44414,"size":23,"leadingEdge":["CEACAM1","PML","MEFV","ZC3H12A","CARD17","CARD16","TNFAIP3","GAS6","CX3CL1","IL1R2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELL_MATRIX_ADHESION","pval":0.70708,"padj":0.9508,"ES":0.59767,"NES":0.85683,"nMoreExtreme":46939,"size":34,"leadingEdge":["FAM107A","BCL6","SRC","SEMA3E"]} {"pathway":"GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_SIGNALING_PATHWAY","pval":0.90759,"padj":0.98435,"ES":0.47086,"NES":0.85558,"nMoreExtreme":88530,"size":586,"leadingEdge":["IL31RA","SOCS1","CEACAM1","HGF","LMTK2","JAK2","AGT","MYOF","CD7","JAK3","RAPGEF2","STAP1","VEGFC","NCF1","MIR503","IGF2R","CISH","MVP","LYN","CSF1","NR4A3","GAREM1","NRG4","FGF10","STAT5A","FLT1","HPN","TRIM72","SMPD3","LCP2","PSEN2","F3","SOCS3","SH2B2","STAT3","PTPN2","PAK1","NRG2","TRIM71","MYO1E","SRC","TGFB1","ROBO1","TXNIP","ATP6V1A","PDGFRA","RHBDF2","PTPN1","RHOQ","SORT1","IFI6","NCF2","ANGPTL1","FOXC1","ESM1","EPHA10","GATA3","NKX3-1","ELMO2","PLCB1","PDGFB"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION","pval":0.76011,"padj":0.96073,"ES":0.51971,"NES":0.85534,"nMoreExtreme":59630,"size":99,"leadingEdge":["JAK2","RSU1","S100A10","CSF1","HAS2","CX3CL1","SMAD3","PTN"]} {"pathway":"GO_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY","pval":0.8782,"padj":0.97973,"ES":0.47457,"NES":0.85524,"nMoreExtreme":83588,"size":415,"leadingEdge":["IDO1","P2RX7","STEAP4","AIFM2","C15orf48","NCF1","NR4A3","PFKP","VGF","SLC25A22","SLC25A25","STAT3","ACSS1","GPD2","NCF2","PRELID1"]} {"pathway":"GO_ESTABLISHMENT_OF_ORGANELLE_LOCALIZATION","pval":0.88401,"padj":0.98086,"ES":0.47382,"NES":0.85513,"nMoreExtreme":84484,"size":438,"leadingEdge":["P2RX7","LRRK2","STX11","GRIN3A","ERC2","PRRT2","S100A13","CHMP4C","DYNLT1","LYN","DTNBP1","CADPS2","NR4A3","CTSZ","FGF10","MEI1","RASGRP1","NTN1","GEM","TRIM9","SYT5","CTSC","MAP2","AP1AR","NAPA","STX3","SYT17","FCER1G","TRIM46"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TROPHOBLAST_CELL_MIGRATION","pval":0.64883,"padj":0.94878,"ES":0.62137,"NES":0.85474,"nMoreExtreme":34331,"size":5,"leadingEdge":["SYDE1","C1QBP","SMURF2","AGO2","ACVR1B"]} {"pathway":"GO_REGULATION_OF_CYTOPLASMIC_TRANSPORT","pval":0.70765,"padj":0.9508,"ES":0.63017,"NES":0.85467,"nMoreExtreme":44816,"size":24,"leadingEdge":["LRRK2","SRC","MAP2","DNAJC13","TRIM46"]} {"pathway":"GO_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS","pval":0.81655,"padj":0.971,"ES":0.49008,"NES":0.85462,"nMoreExtreme":71470,"size":205,"leadingEdge":["CD74","RMI2","MUC1","PML","DTX3L","PMAIP1","PYHIN1","PARP3","PARP9","FGF10","CXCL12","CGAS","HELB","MCL1","NKX3-1"]} {"pathway":"GO_NEPHRIC_DUCT_FORMATION","pval":0.55211,"padj":0.93307,"ES":0.58,"NES":0.85451,"nMoreExtreme":28224,"size":3,"leadingEdge":["GATA3","HNF1B"]} {"pathway":"GO_ORGANIC_ACID_TRANSPORT","pval":0.82296,"padj":0.97426,"ES":0.48801,"NES":0.85441,"nMoreExtreme":72734,"size":219,"leadingEdge":["SLC6A12","P2RX7","CEACAM1","KCNJ10","AGT","ACSL1","P2RX4","EDN1","CTNS","SLC27A3","SLC51A","PLA2G4A","SLC25A22","NCOA1","KMO","SLC7A2","ABCC2","MFSD2A","GLS","NFKBIE"]} {"pathway":"GO_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS","pval":0.79226,"padj":0.96486,"ES":0.50133,"NES":0.85417,"nMoreExtreme":66142,"size":147,"leadingEdge":["CEACAM1","C3","DGAT2","TNF","SMPD3","CYP27B1","NR1H3","FPR2","PTGS2","ERLIN1","PDGFB","RAB38","SIK1","AGAP2","INSIG2","LPGAT1","PROX1"]} {"pathway":"GO_FOREBRAIN_NEURON_DEVELOPMENT","pval":0.71457,"padj":0.9532,"ES":0.64252,"NES":0.85415,"nMoreExtreme":44472,"size":21,"leadingEdge":["RAPGEF2","ATF5","SLC4A10","AUTS2","ROBO1","SLIT2"]} {"pathway":"GO_ERBB_SIGNALING_PATHWAY","pval":0.77957,"padj":0.96109,"ES":0.5078,"NES":0.85404,"nMoreExtreme":63510,"size":125,"leadingEdge":["CEACAM1","AGT","NCF1","MVP","GAREM1","NRG4","PTPN2","NRG2","SRC","TGFB1","RHBDF2","IFI6"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT","pval":0.83512,"padj":0.97443,"ES":0.48456,"NES":0.85394,"nMoreExtreme":75015,"size":248,"leadingEdge":["ASCL2","LRRK2","CD38","KREMEN1","B2M","RAPGEF2","STAP1","DYNLT1","CTSZ","IL6","SEMA7A","TNF","SOX8","DUSP10","ASCL1","NTN1","STAT3","TGFB1","SEMA4A","ISL2","MAP2","RGMA","LPAR1","CX3CL1","LIN28A","SEMA4D","DENND5A","SLIT2","TRIM46","GPR161","RUFY3"]} {"pathway":"GO_PHOSPHATIDYLCHOLINE_ACYL_CHAIN_REMODELING","pval":0.73157,"padj":0.95656,"ES":0.66452,"NES":0.85369,"nMoreExtreme":43822,"size":16,"leadingEdge":["PLAAT3","PLA2G4C","LPCAT2","PLA2G4A"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSPORT","pval":0.70985,"padj":0.95201,"ES":0.60771,"NES":0.85354,"nMoreExtreme":46274,"size":30,"leadingEdge":["ATP1B2","GLRX"]} {"pathway":"GO_REGULATION_OF_ENDOTHELIAL_CELL_CHEMOTAXIS","pval":0.72598,"padj":0.95562,"ES":0.65998,"NES":0.85351,"nMoreExtreme":43870,"size":17,"leadingEdge":["P2RX4","MET"]} {"pathway":"GO_POLYOL_CATABOLIC_PROCESS","pval":0.71267,"padj":0.95313,"ES":0.63741,"NES":0.85337,"nMoreExtreme":44592,"size":22,"leadingEdge":["GK","GPD2","MTMR7"]} {"pathway":"GO_REGULATION_OF_EXECUTION_PHASE_OF_APOPTOSIS","pval":0.71054,"padj":0.95219,"ES":0.63312,"NES":0.85319,"nMoreExtreme":44705,"size":23,"leadingEdge":["ZC3H12A","SIRT2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY","pval":0.73258,"padj":0.95708,"ES":0.55286,"NES":0.85232,"nMoreExtreme":52409,"size":56,"leadingEdge":["PLEK","S100A10","PPM1E","CD47","PAK1","LPAR1","CX3CL1","SMAD3","LIMK1"]} {"pathway":"GO_ADULT_BEHAVIOR","pval":0.76164,"padj":0.96082,"ES":0.52177,"NES":0.85224,"nMoreExtreme":59034,"size":92,"leadingEdge":["KCNJ10","SPTBN4","CTNS","NR4A3","CXCL12","NR4A2","SEZ6L","PAX5","NPC1"]} {"pathway":"GO_REGULATION_OF_PLATELET_AGGREGATION","pval":0.74178,"padj":0.95912,"ES":0.66968,"NES":0.85224,"nMoreExtreme":43661,"size":14,"leadingEdge":["CEACAM1","LYN","PRKCQ"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS","pval":0.82469,"padj":0.97439,"ES":0.48759,"NES":0.85214,"nMoreExtreme":72576,"size":213,"leadingEdge":["CD40","TBX21","PML","DTX3L","PARP3","PARP9","ANXA3","FGF10","PTPRC","NBN","TGFB1","OTUD4","LIN28A","ZFP36"]} {"pathway":"GO_NEUROTRANSMITTER_RECEPTOR_TRANSPORT_POSTSYNAPTIC_ENDOSOME_TO_LYSOSOME","pval":0.55326,"padj":0.93347,"ES":0.57839,"NES":0.85213,"nMoreExtreme":28283,"size":3,"leadingEdge":["AP3D1","CACNG4","CACNG8"]} {"pathway":"GO_INTERLEUKIN_10_SECRETION","pval":0.7357,"padj":0.95787,"ES":0.65998,"NES":0.85185,"nMoreExtreme":40537,"size":8,"leadingEdge":["CD274","LILRB1","LILRA5"]} {"pathway":"GO_REGULATION_OF_LIPID_TRANSPORT","pval":0.75076,"padj":0.9603,"ES":0.53095,"NES":0.85102,"nMoreExtreme":56570,"size":77,"leadingEdge":["P2RX7","AGT","P2RX4","EDN1","TTC39B","LIPG","NR1H3","NFKBIA","PRELID1","NKX3-1"]} {"pathway":"GO_ACIDIC_AMINO_ACID_TRANSPORT","pval":0.72822,"padj":0.95596,"ES":0.5601,"NES":0.85087,"nMoreExtreme":51222,"size":50,"leadingEdge":["P2RX7","KCNJ10","SLC25A22","KMO","GLS","ADORA2A","TSPOAP1"]} {"pathway":"GO_CARDIAC_VENTRICLE_MORPHOGENESIS","pval":0.73571,"padj":0.95787,"ES":0.55167,"NES":0.85049,"nMoreExtreme":52633,"size":56,"leadingEdge":["MYH7","TGFB1","FOXC1","GATA3","HEG1","PROX1","SMARCD3"]} {"pathway":"GO_MICROTUBULE_BUNDLE_FORMATION","pval":0.73731,"padj":0.95787,"ES":0.54759,"NES":0.85026,"nMoreExtreme":53260,"size":59,"leadingEdge":["DNAAF1","LRRC61","CCSER2","MAP2","TPPP","CFAP74","GAS8","TRIM46"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_THYMOCYTE_APOPTOTIC_PROCESS","pval":0.73643,"padj":0.95787,"ES":0.65861,"NES":0.85008,"nMoreExtreme":40577,"size":8,"leadingEdge":["JAK3","HIF1A"]} {"pathway":"GO_REGULATION_OF_ASPARTIC_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS","pval":0.74626,"padj":0.96025,"ES":0.66507,"NES":0.84949,"nMoreExtreme":41703,"size":9,"leadingEdge":["LYN","PICALM"]} {"pathway":"GO_CYTOPLASMIC_SEQUESTERING_OF_PROTEIN","pval":0.71447,"padj":0.9532,"ES":0.62623,"NES":0.84933,"nMoreExtreme":45248,"size":24,"leadingEdge":["SRI","NFKBIA","NFKBIE","PKD1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_GENE_SILENCING","pval":0.72256,"padj":0.95558,"ES":0.64332,"NES":0.84931,"nMoreExtreme":44664,"size":20,"leadingEdge":["ZC3H12A","TGFB1","ELAVL1"]} {"pathway":"GO_CHONDROBLAST_DIFFERENTIATION","pval":0.55465,"padj":0.93396,"ES":0.57642,"NES":0.84923,"nMoreExtreme":28354,"size":3,"leadingEdge":["RARA","FGF2","CCN1"]} {"pathway":"GO_SODIUM_ION_TRANSMEMBRANE_TRANSPORT","pval":0.76735,"padj":0.96082,"ES":0.51853,"NES":0.84899,"nMoreExtreme":59723,"size":94,"leadingEdge":["ATP1B2","SLC12A3","CAMK2D","SLC8A1","SCN9A","SLC8A2","GLRX","STOM","SLC9A4"]} {"pathway":"GO_REGULATION_OF_MEMBRANE_REPOLARIZATION","pval":0.7139,"padj":0.9532,"ES":0.61433,"NES":0.84858,"nMoreExtreme":45903,"size":27,"leadingEdge":["KCNJ2","ANK2","KCNE5","RNF207","KCNE1","KCNE1B"]} {"pathway":"GO_RESPONSE_TO_ANTINEOPLASTIC_AGENT","pval":0.75573,"padj":0.9603,"ES":0.5292,"NES":0.84822,"nMoreExtreme":56945,"size":77,"leadingEdge":["XRN1","ICAM1","ZC3H12A","EDN1","NUCB1","PTAFR","TGFB1","ASNS","CFLAR","PDGFB","SLC31A1","ASS1"]} {"pathway":"GO_GROWTH_PLATE_CARTILAGE_CHONDROCYTE_DIFFERENTIATION","pval":0.73171,"padj":0.95656,"ES":0.65571,"NES":0.84798,"nMoreExtreme":44216,"size":17,"leadingEdge":["COCH","COL27A1","COL12A1"]} {"pathway":"GO_SENSORY_ORGAN_DEVELOPMENT","pval":0.88507,"padj":0.98086,"ES":0.47165,"NES":0.84796,"nMoreExtreme":83715,"size":386,"leadingEdge":["ASCL2","C1QB","LIMK2","CYP1A1","KLF4","BCL2L11","EDN1","SCO2","CTNS","TIFAB","NR4A3","FGF10","SOX8","HPN","ASCL1","NTN1","SLC25A25","STAT3","TGIF2","TGFB1","VAX2","PDGFRA","CDKN1C","GPD2","FOXC1","GATA3","TDRD7","SMAD3","PDZD7","BAK1","RAB11FIP4","RORB","ESRRB","COL8A2","INSIG2","PLPPR4","ALDH1A2","TBX1","PROX1","SOX2","PTN","NEUROG1","WNT1"]} {"pathway":"GO_MUSCLE_HYPERTROPHY_IN_RESPONSE_TO_STRESS","pval":0.73179,"padj":0.95656,"ES":0.6556,"NES":0.84783,"nMoreExtreme":44221,"size":17,"leadingEdge":["MYH7","SMAD3","HDAC4"]} {"pathway":"GO_NUCLEOSIDE_PHOSPHATE_BIOSYNTHETIC_PROCESS","pval":0.84195,"padj":0.97458,"ES":0.48251,"NES":0.8476,"nMoreExtreme":75053,"size":234,"leadingEdge":["IDO1","IDO2","ACSL1","VPS9D1","PARP10","NPR1","CMPK2","CDS1","PARP9","KYNU","ACSL5","ELOVL7","KMO","STAT3","GUCA1A","TGFB1","AGPAT3","ACSS1","NAMPT","GUCY1A1","PTGS2","GUCY1B1","AK4","NADK","RFK"]} {"pathway":"GO_RESPONSE_TO_ISCHEMIA","pval":0.72539,"padj":0.95562,"ES":0.57632,"NES":0.84756,"nMoreExtreme":49445,"size":40,"leadingEdge":["P2RX7","P2RX4","CSF1","CX3CL1","PANX2"]} {"pathway":"GO_PROTON_TRANSMEMBRANE_TRANSPORT","pval":0.78696,"padj":0.96311,"ES":0.50687,"NES":0.8475,"nMoreExtreme":63432,"size":117,"leadingEdge":["VPS9D1","SLC2A6","C15orf48","SLC4A10","UCP2","ATP6V1A","CLCN4","HVCN1","SLC9A4"]} {"pathway":"GO_T_CELL_CHEMOTAXIS","pval":0.727,"padj":0.95562,"ES":0.64599,"NES":0.84707,"nMoreExtreme":44650,"size":19,"leadingEdge":["CXCL11","CXCL10","CCL5","CXCL16","CCL3"]} {"pathway":"GO_NUCLEIC_ACID_PHOSPHODIESTER_BOND_HYDROLYSIS","pval":0.85091,"padj":0.97645,"ES":0.47984,"NES":0.84702,"nMoreExtreme":76755,"size":256,"leadingEdge":["ISG20","XRN1","ZC3H12A","HORMAD1","ENPP2","PIWIL4","HELZ2","MOV10","ERI1","ENDOD1","ZFP36","TSEN34","CECR2"]} {"pathway":"GO_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION","pval":0.72271,"padj":0.95558,"ES":0.6371,"NES":0.84695,"nMoreExtreme":44978,"size":21,"leadingEdge":["CEACAM1","CCL5","LYN","PRKCQ"]} {"pathway":"GO_NOSE_DEVELOPMENT","pval":0.75253,"padj":0.9603,"ES":0.66855,"NES":0.8466,"nMoreExtreme":43407,"size":12,"leadingEdge":["ASCL1","PROX1","SIX1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INTERLEUKIN_4_PRODUCTION","pval":0.72848,"padj":0.95596,"ES":0.64499,"NES":0.84576,"nMoreExtreme":44741,"size":19,"leadingEdge":["HLA-E","IRF4","CD86","GATA3","IL33","FCER1G","PRKCQ"]} {"pathway":"GO_TRANSMISSION_OF_NERVE_IMPULSE","pval":0.72893,"padj":0.95596,"ES":0.57314,"NES":0.84569,"nMoreExtreme":49818,"size":41,"leadingEdge":["AGT","TYMP","SPTBN4","P2RX4","NRCAM","SCN9A","CACNA1I","GPR35","KCNMB4","SCN3A"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MACROPHAGE_MIGRATION","pval":0.7486,"padj":0.9603,"ES":0.66151,"NES":0.84495,"nMoreExtreme":41834,"size":9,"leadingEdge":["STAP1","SLAMF8","CD200"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_B_CELL_PROLIFERATION","pval":0.7438,"padj":0.95959,"ES":0.66125,"NES":0.84484,"nMoreExtreme":44198,"size":15,"leadingEdge":["CTLA4","LYN","MNDA","BTK"]} {"pathway":"GO_ENZYME_LINKED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY","pval":0.95025,"padj":0.99215,"ES":0.46241,"NES":0.84462,"nMoreExtreme":94169,"size":826,"leadingEdge":["IL31RA","SOCS1","CEACAM1","HGF","CHRD","LMTK2","JAK2","AGT","MYOF","CD7","ONECUT2","PML","JAK3","RAPGEF2","STAP1","NPR1","VEGFC","NCF1","MIR503","IGF2R","CISH","MVP","COMP","LYN","CSF1","NR4A3","PTPRU","GAREM1","NRG4","FGF10","HTRA4","CHST11","FST","STAT5A","FLT1","HPN","TRIM72","SMPD3","LCP2","PSEN2","F3","SOCS3","SH2B2","STAT3","PTPN2","PAK1","NRG2","TRIM71","MYO1E","TGIF2","SRC","TGFB1","ROBO1","TXNIP","ATP6V1A","PDGFRA","RHBDF2","CDKN1C","PTPN1","RHOQ","SORT1","RGMA","IFI6","NCF2","GAS6","ANGPTL1","FOXC1","ESM1","EPHA10","LIFR","GATA3","NKX3-1","MIR212","ELMO2","PLCB1","PDGFB","SMAD3"]} {"pathway":"GO_NITROGEN_UTILIZATION","pval":0.5987,"padj":0.94558,"ES":0.59302,"NES":0.84448,"nMoreExtreme":31159,"size":4,"leadingEdge":["GLUL","BAX"]} {"pathway":"GO_REGULATION_OF_ASPARTIC_TYPE_PEPTIDASE_ACTIVITY","pval":0.75456,"padj":0.9603,"ES":0.66507,"NES":0.84432,"nMoreExtreme":42591,"size":10,"leadingEdge":["LYN","GRN"]} {"pathway":"GO_GLAND_DEVELOPMENT","pval":0.88379,"padj":0.98086,"ES":0.47115,"NES":0.84416,"nMoreExtreme":82878,"size":352,"leadingEdge":["CEACAM1","HGF","JAK2","ONECUT2","CYP1A1","HESX1","BCL2L11","DNAAF1","TGM2","PML","IGF2R","POLB","OAS2","CSF1","EPHX1","TNFAIP3","FGF10","TBX19","TNF","STAT5A","HPN","NCOA1","ASCL1","NTN1","SRC","TGFB1","ROBO1","UCP2","PDGFRA","CDKN1C","ASNS","FOXC1","CFLAR","GATA3","NKX3-1","AK4","SMAD3","HLX","ARID5B","ASS1","ALDH1A2","COBL","TBX1","MET","PROX1","LSR","SOX2","PTN","WNT1","HNF1B"]} {"pathway":"GO_CIRCULATORY_SYSTEM_DEVELOPMENT","pval":0.95526,"padj":0.9934,"ES":0.46184,"NES":0.84387,"nMoreExtreme":94766,"size":866,"leadingEdge":["CD40","CXCL10","CEACAM1","TNFAIP2","AMOT","HGF","STAT1","AGT","PIM1","TYMP","VCAM1","KLF4","DNAAF1","PML","SRI","C3","ZC3H12A","RAPGEF2","NPR1","XIRP1","ENPP2","EDN1","VEGFC","MIR503","SAT1","ANK2","COMP","DYSF","HLA-G","GLUL","CDKL1","NRCAM","SOD2","PRKX","TNFAIP3","ANXA3","MYH7","RNF207","IL6","TLR3","FGF10","EGR3","NOTCH2","FLT1","SLC8A1","ADM2","ASCL1","CHI3L1","F3","SOCS3","CCL2","STAT3","PAK1","MYO1E","ANGPTL4","RUNX1","TGFB1","SEMA4A","ROBO1","CXCL8","CDKN1A","PDGFRA","ACTN2","ADGRB1","PTGS2","HAS2","CX3CL1","FOXC1","CFLAR","ESM1","GATA3","NKX3-1","NFE2L2","MIR212","ERAP1","PDGFB","SMAD3","SLIT2","BAK1","IL1A","SIK1","EDNRA","COL8A2","PPP1R16B","S100A1","HEG1"]} {"pathway":"GO_FATTY_ACID_METABOLIC_PROCESS","pval":0.8348,"padj":0.97443,"ES":0.48489,"NES":0.84383,"nMoreExtreme":72743,"size":198,"leadingEdge":["ACOD1","ACSL1","CYP1A1","C3","ACOT4","DGAT2","GGT5","NR4A3","SLC27A3","PLA2G4C","DECR1","CBR1","PLA2G4A","ACSL5","PTGS2","CES1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PEPTIDYL_LYSINE_ACETYLATION","pval":0.72131,"padj":0.95476,"ES":0.60716,"NES":0.84376,"nMoreExtreme":46594,"size":28,"leadingEdge":["MUC1","AUTS2","TGFB1","GATA3","SNAI2"]} {"pathway":"GO_ATRIAL_SEPTUM_PRIMUM_MORPHOGENESIS","pval":0.65166,"padj":0.94878,"ES":0.61328,"NES":0.84361,"nMoreExtreme":34481,"size":5,"leadingEdge":["TGFB2","NSD2","ACVR1","SOX4","GATA4"]} {"pathway":"GO_MRNA_METABOLIC_PROCESS","pval":0.91285,"padj":0.9862,"ES":0.46601,"NES":0.84349,"nMoreExtreme":87990,"size":490,"leadingEdge":["XRN1","RBM11","STAT3","ELAVL4","ADAR","PRPF3","CIR1","TSEN34","EREG"]} {"pathway":"GO_TUBE_MORPHOGENESIS","pval":0.93777,"padj":0.98783,"ES":0.46273,"NES":0.84341,"nMoreExtreme":92351,"size":690,"leadingEdge":["CD40","CXCL10","CEACAM1","TNFAIP2","AMOT","HGF","STAT1","AGT","TYMP","KLF4","BCL2L11","DNAAF1","TGM2","PML","C3","ZC3H12A","RAPGEF2","NPR1","ENPP2","EDN1","VEGFC","MIR503","SAT1","COMP","DYSF","HLA-G","GLUL","CSF1","NR4A3","NRCAM","PRKX","TNFAIP3","ANXA3","RNF207","CTSZ","IL6","TLR3","FGF10","EGR3","TNF","SOX8","FLT1","ADM2","NTN1","CHI3L1","F3","CCL2","STAT3","PAK1","TRIM71","MYO1E","ANGPTL4","PODXL","RUNX1","SRC","TGFB1","SEMA4A","ROBO1","CXCL8","PDGFRA","ADGRB1","PTGS2","HAS2","CX3CL1","FOXC1","ESM1","GATA3","NKX3-1","NFE2L2","MIR212","ERAP1","SMAD3","SLIT2","BAK1","IL1A","HLX","HOXD11","EDNRA","COL8A2","PPP1R16B","S100A1","HEG1"]} {"pathway":"GO_RENAL_ABSORPTION","pval":0.7552,"padj":0.9603,"ES":0.66584,"NES":0.84316,"nMoreExtreme":43561,"size":12,"leadingEdge":["HAS2","GAS6","KCNQ1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS","pval":0.73713,"padj":0.95787,"ES":0.65192,"NES":0.84308,"nMoreExtreme":44544,"size":17,"leadingEdge":["HCAR2","TNF","ACACB"]} {"pathway":"GO_NUCLEOSIDE_PHOSPHATE_CATABOLIC_PROCESS","pval":0.74908,"padj":0.9603,"ES":0.54389,"NES":0.84288,"nMoreExtreme":53950,"size":58,"leadingEdge":["PDE4B","ENTPD2"]} {"pathway":"GO_NEUROGENESIS","pval":0.97943,"padj":0.99901,"ES":0.46018,"NES":0.84287,"nMoreExtreme":97818,"size":1289,"leadingEdge":["ASCL2","LRRK2","CD38","HGF","KREMEN1","EGR2","GRIN3A","KCNJ10","JAK2","AGT","ONECUT2","BHLHE41","GLDN","VCAM1","SPTBN4","MDGA1","KLF4","SCARF1","B2M","C3","RASGRF1","P2RX4","RAPGEF2","STAP1","ATF5","VEGFC","NRK","C21orf91","DYNLT1","BCL6","LYN","DTNBP1","CHAC1","CSF1","LTA","NR4A3","EPOP","NYAP2","NRCAM","RND1","B4GALT5","CTSZ","IL6","FGF10","SEMA7A","TNF","SOX8","DGKG","DUSP10","CAMK1D","MOV10","FARP2","NCOA1","ASCL1","UNC5C","NTN1","CXCL12","SLC4A10","NR4A2","AUTS2","FPR2","CCL2","STAT3","P2RY12","PAK1","TGIF2","RUNX1","SRC","TGFB1","VAX2","SEMA4A","NTNG2","ROBO1","STMN3","STMND1","CDKN1C","ISL2","MAP2","RGMA","ADGRB1","LIG4","SH3RF1","LPAR1","GPM6B","ASTN1","GAS6","CCL3","CX3CL1","CFLAR","EPHA10","GATA3","NFE2L2","SRCIN1","IL33","LIN28A","SEMA4D","NAPA","STX3","SYT17","DENND5A","PDZD7","SPTA1","SLIT2","RORB","BOC","TRIM46","NGF","C9orf72","FLOT1","ARC","TLR4","MAPK8IP2","RUFY3","PLPPR4","ALDH1A2","COBL","MET","PROX1","MCF2","HAP1","ADORA2A","SOX2","LIMK1","PTN","LZTS1","NPTX1","NEUROG1","WNT1","SEMA3F","BTG2"]} {"pathway":"GO_RESPONSE_TO_PHORBOL_13_ACETATE_12_MYRISTATE","pval":0.55812,"padj":0.93517,"ES":0.5717,"NES":0.84228,"nMoreExtreme":28531,"size":3,"leadingEdge":["MAP4K1","CDK4","ADAM15"]} {"pathway":"GO_CELLULAR_DETOXIFICATION_OF_ALDEHYDE","pval":0.59945,"padj":0.94564,"ES":0.59128,"NES":0.84201,"nMoreExtreme":31198,"size":4,"leadingEdge":["RDH11","PARK7","AKR1A1","RDH12"]} {"pathway":"GO_POSITIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION","pval":0.72365,"padj":0.95562,"ES":0.62068,"NES":0.8418,"nMoreExtreme":45829,"size":24,"leadingEdge":["GTF2B","HNF1B","PSMC4"]} {"pathway":"GO_DOPAMINE_RECEPTOR_SIGNALING_PATHWAY","pval":0.72474,"padj":0.95562,"ES":0.60526,"NES":0.84112,"nMoreExtreme":46816,"size":28,"leadingEdge":["LRRK2","DTNBP1","RGS9"]} {"pathway":"GO_NUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS","pval":0.75532,"padj":0.9603,"ES":0.53842,"NES":0.8411,"nMoreExtreme":55011,"size":62,"leadingEdge":["ACSL1","ACSL5","ELOVL7","ACSS1","PDK2"]} {"pathway":"GO_REGULATION_OF_MEMBRANE_INVAGINATION","pval":0.74717,"padj":0.96029,"ES":0.6583,"NES":0.84107,"nMoreExtreme":44398,"size":15,"leadingEdge":["C3","STAP1","ABCA7"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_PEPTIDE_HORMONE_STIMULUS","pval":0.86042,"padj":0.97645,"ES":0.47702,"NES":0.84065,"nMoreExtreme":77288,"size":248,"leadingEdge":["SOCS1","CEACAM1","STAT1","JAK2","AGT","JAK3","EDN1","CISH","LYN","NR4A3","STAT5A","TRIM72","NR4A2","SOCS3","SH2B2","STAT3","PTPN2","PAK1","GCLC","SRC","TGFB1","UCP2","ATP6V1A","PTPN1","RHOQ","ACTN2","CFLAR","AGTRAP","NFE2L2"]} {"pathway":"GO_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY","pval":0.74857,"padj":0.9603,"ES":0.54888,"NES":0.84055,"nMoreExtreme":53152,"size":53,"leadingEdge":["JAK2","NR4A3","SMPD3","F3","PTPN2","MYO1E","SRC","TXNIP","PDGFRA","PTPN1","PDGFB","ARID5B"]} {"pathway":"GO_METHIONINE_BIOSYNTHETIC_PROCESS","pval":0.75694,"padj":0.9603,"ES":0.66181,"NES":0.84019,"nMoreExtreme":42725,"size":10,"leadingEdge":["MTHFR","MRI1"]} {"pathway":"GO_NUCLEUS_ORGANIZATION","pval":0.79604,"padj":0.96646,"ES":0.50492,"NES":0.84018,"nMoreExtreme":63621,"size":111,"leadingEdge":["GOLM1","PML","CHMP4C","ATXN7","PARP11","REEP4"]} {"pathway":"GO_ASYMMETRIC_NEUROBLAST_DIVISION","pval":0.69497,"padj":0.94995,"ES":0.62798,"NES":0.83972,"nMoreExtreme":37298,"size":6,"leadingEdge":["TEAD3","RAB10","ARHGEF2","DOCK7","FGF13","SOX5"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ORGANIC_ACID_TRANSPORT","pval":0.72942,"padj":0.95596,"ES":0.62713,"NES":0.83961,"nMoreExtreme":45640,"size":22,"leadingEdge":["P2RX7","AGT","P2RX4","EDN1","KMO","ADORA2A"]} {"pathway":"GO_NEURON_PROJECTION_ARBORIZATION","pval":0.74092,"padj":0.95908,"ES":0.64923,"NES":0.83961,"nMoreExtreme":44773,"size":17,"leadingEdge":["LRRK2","MOV10","DVL2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ORGANELLE_ORGANIZATION","pval":0.92676,"padj":0.987,"ES":0.4625,"NES":0.83945,"nMoreExtreme":90068,"size":553,"leadingEdge":["P2RX7","CALCOCO2","LRRK2","PLEK","TNFSF10","OPTN","ICAM1","BCL2L11","MUC1","PML","STAP1","SCIN","RALB","EDN1","PMAIP1","S100A10","BCL6","PPM1E","NPM2","TNF","CD47","SMPD3","ACTR3C","AUTS2","NBN","PAK1","SRC","TGFB1","CDC42EP2","UVRAG","ACTN2","LIG4","LPAR1","CX3CL1","AP1AR","GATA3","BBC3","PLCB1","PDGFB","SMAD3","BAK1","IL1A","DDHD1"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS","pval":0.83508,"padj":0.97443,"ES":0.48631,"NES":0.83877,"nMoreExtreme":71389,"size":174,"leadingEdge":["SOCS1","CEACAM1","STAT1","AGT","CISH","TRIM72","SOCS3","SH2B2","PTPN2","PAK1","GCLC","SRC","UCP2","ATP6V1A","PTPN1","RHOQ","CFLAR"]} {"pathway":"GO_REGULATION_OF_TRANSFERASE_ACTIVITY","pval":0.95756,"padj":0.9934,"ES":0.45905,"NES":0.83853,"nMoreExtreme":94912,"size":832,"leadingEdge":["CD40","CD74","P2RX7","SOCS1","LRRK2","CXCL10","NOD2","CEACAM1","HGF","NLRC5","JAK2","AGT","RIPK2","ACSL1","KLF4","FAM20A","RAPGEF2","STAP1","RALB","EDN1","NCF1","DTX3L","NRK","CISH","MVP","GADD45B","SLAMF8","PPM1E","CCL5","LYN","DTNBP1","CSF1","PARP3","TNFAIP3","TLR3","FGF10","TXN","GADD45G","TNF","FLT1","DUSP10","RASGRP1","FGD2","LCP2","PTPRC","CHI3L1","RHOH","FPR2","SOCS3","NBN","P2RY12","PTPN2","PAK1","SRC","TGFB1","ROBO1","CCL19","CDKN1A","UVRAG","PDGFRA","ADAR","DUSP5","CDKN1C","PTPN1","CCNL1","LPAR1","GAS6","TCIM","BIRC7","SRCIN1","CCNA1"]} {"pathway":"GO_RESPIRATORY_BURST","pval":0.72943,"padj":0.95596,"ES":0.60267,"NES":0.83752,"nMoreExtreme":47119,"size":28,"leadingEdge":["NCF1","SLAMF8","NCF1B","NCF1C","DUSP10","CAMK1D","NCF2"]} {"pathway":"GO_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION","pval":0.88429,"padj":0.98086,"ES":0.47025,"NES":0.83732,"nMoreExtreme":81538,"size":305,"leadingEdge":["AMOT","TAGAP","JAK2","ARAP2","RASGRF1","BCL6","LYN","CSF1","ARHGEF3","ARHGAP25","FGF10","NOTCH2","GPR18","RASGRP1","F2RL2","FARP2","FGD2","RHOH","AUTS2","SH2B2","SRC","ARHGAP17","A2M","IQSEC3","ROBO1","STMN3","RHOQ","LPAR1","RIPOR2","FGD6","CDC42SE2","SLIT2","NGF","ARHGEF11","FLOT1","HEG1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_DEPHOSPHORYLATION","pval":0.78926,"padj":0.96429,"ES":0.51138,"NES":0.83728,"nMoreExtreme":61428,"size":94,"leadingEdge":["LMTK2","TNF","ELFN1","SEMA4D","MYOZ1","PPP1R16B","PTN","DLG3"]} {"pathway":"GO_OSSIFICATION","pval":0.88599,"padj":0.98086,"ES":0.46947,"NES":0.83685,"nMoreExtreme":81897,"size":311,"leadingEdge":["P2RX7","SNX10","HGF","KREMEN1","CHRD","EGR2","IFITM1","SBNO2","COMP","PTGER4","CSF1","IL6","SEMA7A","TNF","SOX8","SLC8A1","SMPD3","CYP27B1","TGFB1","SORT1","ISG15","GPM6B","PTGS2","CCL3","FOXC1","PPARGC1B","SEMA4D","DNAJC13","SMAD3"]} {"pathway":"GO_PROTEIN_KINASE_C_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY","pval":0.73287,"padj":0.95712,"ES":0.62495,"NES":0.83669,"nMoreExtreme":45856,"size":22,"leadingEdge":["EDN1","CISH","DGKG","PLPP1","ADORA2A"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_GLUCOSE_STARVATION","pval":0.7422,"padj":0.95912,"ES":0.56701,"NES":0.83664,"nMoreExtreme":50725,"size":41,"leadingEdge":["ZC3H12A","PMAIP1","SIK1B","NUAK2","ASNS","NFE2L2","SIK1"]} {"pathway":"GO_REGULATION_OF_CELL_SIZE","pval":0.82993,"padj":0.97439,"ES":0.48843,"NES":0.83664,"nMoreExtreme":70042,"size":157,"leadingEdge":["P2RX7","PLEK","SLC12A3","EDN1","NRCAM","SEMA7A","SLC12A7","NTN1","CXCL12","PAK1","SEMA4A","KCNMA1","MAP2","SEMA4D","TRIM46","NGF","RUFY3"]} {"pathway":"GO_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION","pval":0.7443,"padj":0.95959,"ES":0.56286,"NES":0.83657,"nMoreExtreme":51250,"size":43,"leadingEdge":["STAT1","B2M","LYN","STAT3","ISG15","ZFP36"]} {"pathway":"GO_EMBRYONIC_MORPHOGENESIS","pval":0.91816,"padj":0.987,"ES":0.46257,"NES":0.83575,"nMoreExtreme":88026,"size":455,"leadingEdge":["AMOT","CHRD","ITGA7","KLF4","BCL2L11","DNAAF1","EDN1","VEGFC","IL1RN","TIFAB","NR4A3","RNF207","FGF10","CHST11","SOX8","FLT1","HPN","NCOA1","NTN1","AUTS2","SOCS3","TRIM71","TGIF2","TGFB1","VAX2","PDGFRA","CDKN1C","FOXC1","GATA3","SMAD3","PDZD7","PAX5","HLX","INSIG2","MTHFR","ALDH1A2","COBL","TBX1","PROX1","SOX2","NEUROG1","WNT1","HNF1B","PRICKLE1"]} {"pathway":"GO_LYMPH_VESSEL_MORPHOGENESIS","pval":0.74529,"padj":0.96025,"ES":0.64613,"NES":0.83559,"nMoreExtreme":45037,"size":17,"leadingEdge":["VEGFC","FOXC1","PROX1","PKD1"]} {"pathway":"GO_SEMI_LUNAR_VALVE_DEVELOPMENT","pval":0.73657,"padj":0.95787,"ES":0.58553,"NES":0.83544,"nMoreExtreme":48689,"size":33,"leadingEdge":["NOTCH2","TGFB1","ROBO1","GATA3","SLIT2","SNAI2"]} {"pathway":"GO_CELLULAR_COMPONENT_MORPHOGENESIS","pval":0.96662,"padj":0.99537,"ES":0.45688,"NES":0.83524,"nMoreExtreme":96037,"size":918,"leadingEdge":["GBP1","P2RX7","LRRK2","CCL13","HGF","EGR2","PSMB10","ITGA7","CCL7","SPTBN4","ICAM1","SIDT2","S100A13","RAPGEF2","ENPP2","EDN1","NRK","RHOBTB3","ANK2","S100A10","FMNL2","BCL6","DTNBP1","NR4A3","NYAP2","NRCAM","RND1","B4GALT5","PLEKHO1","SEMA7A","HPN","MOV10","FGD2","UNC5C","NTN1","CXCL12","RHOH","NR4A2","AUTS2","CCL2","ITGB7","PAK1","SRC","VAX2","SEMA4A","NTNG2","CDC42EP2","ROBO1","GP1BA","PDGFRA","ISL2","RHOQ","ACTN2","MAP2","ADGRB1","LPAR1","HAS2","CCL3","AP1AR","CFLAR","EPHA10","GATA3","SRCIN1","SEMA4D","RILPL1","FGD6","SYT17","CDC42SE2","PDZD7","SPTA1","SLIT2","MYOZ1","BOC","TRIM46","NGF","C9orf72","FLOT1","ARC","HEG1","MAPK8IP2","RUFY3","PLPPR4","NBEAL2","COBL","MET","PROX1","MCF2","ADORA2A","LIMK1","PTN","COCH","LZTS1","NPTX1"]} {"pathway":"GO_REGULATION_OF_ERBB_SIGNALING_PATHWAY","pval":0.78507,"padj":0.96311,"ES":0.51733,"NES":0.83389,"nMoreExtreme":59646,"size":81,"leadingEdge":["CEACAM1","AGT","NCF1","PTPN2","RHBDF2","IFI6","EREG","RNF115","HAP1"]} {"pathway":"GO_SIALYLATION","pval":0.74703,"padj":0.96029,"ES":0.64479,"NES":0.83385,"nMoreExtreme":45142,"size":17,"leadingEdge":["ST3GAL5","ST6GALNAC2","ST3GAL1"]} {"pathway":"GO_ORGAN_INDUCTION","pval":0.74353,"padj":0.95959,"ES":0.64001,"NES":0.83352,"nMoreExtreme":45237,"size":18,"leadingEdge":["FGF10","ROBO1","SIX1","HOXA11"]} {"pathway":"GO_REGULATION_OF_NEURON_DIFFERENTIATION","pval":0.93403,"padj":0.98762,"ES":0.45938,"NES":0.83341,"nMoreExtreme":90646,"size":541,"leadingEdge":["LRRK2","CD38","HGF","KREMEN1","AGT","KLF4","SCARF1","B2M","RAPGEF2","C21orf91","BCL6","LYN","NRCAM","CTSZ","SEMA7A","SOX8","CAMK1D","MOV10","NCOA1","ASCL1","NTN1","CXCL12","PAK1","TGIF2","SEMA4A","ROBO1","ISL2","MAP2","RGMA","LPAR1","CX3CL1","CFLAR","GATA3","NFE2L2","SRCIN1","LIN28A","SEMA4D","SYT17","DENND5A","SLIT2","TRIM46","NGF","ARC","RUFY3","COBL","PROX1","MCF2","SOX2","LIMK1","PTN","LZTS1","NEUROG1","SEMA3F","GDPD5","MAP6","SEMA3E"]} {"pathway":"GO_POSITIVE_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION","pval":0.74069,"padj":0.95908,"ES":0.63126,"NES":0.8334,"nMoreExtreme":45785,"size":20,"leadingEdge":["AGT","IL6","TGFB1","CFLAR","SMAD3","PHLDB1"]} {"pathway":"GO_MACROPHAGE_MIGRATION","pval":0.74464,"padj":0.95978,"ES":0.5686,"NES":0.83329,"nMoreExtreme":50577,"size":39,"leadingEdge":["MCOLN2","P2RX4","STAP1","SLAMF8","CCL5","CSF1","CCL2","P2RY12","CCL3","CX3CL1"]} {"pathway":"GO_THIOESTER_BIOSYNTHETIC_PROCESS","pval":0.75481,"padj":0.9603,"ES":0.55135,"NES":0.83312,"nMoreExtreme":52847,"size":48,"leadingEdge":["ACSL1","ACSL5","ELOVL7","ACSS1","PDK2"]} {"pathway":"GO_DIGESTION","pval":0.7694,"padj":0.96082,"ES":0.53227,"NES":0.83312,"nMoreExtreme":56195,"size":63,"leadingEdge":["SNX10","NOD2","TYMP","GCNT3","TIFAB","FGF10","ADM2","NR1H3"]} {"pathway":"GO_REGULATION_OF_NEUROTRANSMITTER_UPTAKE","pval":0.75205,"padj":0.9603,"ES":0.64845,"NES":0.83304,"nMoreExtreme":45049,"size":16,"leadingEdge":["GPM6B","FLOT1","DRD4"]} {"pathway":"GO_EPITHELIAL_TUBE_BRANCHING_INVOLVED_IN_LUNG_MORPHOGENESIS","pval":0.73524,"padj":0.95787,"ES":0.61019,"NES":0.83269,"nMoreExtreme":46837,"size":25,"leadingEdge":["CTSZ","FGF10","TNF","LAMA1"]} {"pathway":"GO_RESPONSE_TO_ACID_CHEMICAL","pval":0.88146,"padj":0.98086,"ES":0.47034,"NES":0.83245,"nMoreExtreme":80036,"size":269,"leadingEdge":["SOCS1","CD38","ACSL1","ICAM1","KLF4","ZC3H12A","EDN1","IGF2R","DGAT2","PTGER4","LYN","TNF","PTGER2","NCOA1","ASCL1","PTAFR","GCLC","SRC","CCL19","UCP2","PDGFRA","RRAGC","PTGS2","ASNS","RRAGD","PDGFB","MICB","RORB","UBR1","INSIG2","CPT1A","KCNMB1","ASS1","MTHFR","ALDH1A2","TBX1"]} {"pathway":"GO_C_TERMINAL_PROTEIN_DEGLUTAMYLATION","pval":0.75347,"padj":0.9603,"ES":0.62454,"NES":0.83243,"nMoreExtreme":37701,"size":1,"leadingEdge":["AGTPBP1"]} {"pathway":"GO_SINGLE_STRANDED_VIRAL_RNA_REPLICATION_VIA_DOUBLE_STRANDED_DNA_INTERMEDIATE","pval":0.74845,"padj":0.9603,"ES":0.64357,"NES":0.83228,"nMoreExtreme":45228,"size":17,"leadingEdge":["APOBEC3D","APOBEC3G","APOBEC3F","CXCL8"]} {"pathway":"GO_T_CELL_DIFFERENTIATION_IN_THYMUS","pval":0.7676,"padj":0.96082,"ES":0.53695,"NES":0.83212,"nMoreExtreme":55284,"size":58,"leadingEdge":["CD74","B2M","EGR3","RASGRP1","PTPRC","PTPN2","CCR6","LIG4","GATA3"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_DEXAMETHASONE_STIMULUS","pval":0.73599,"padj":0.95787,"ES":0.61351,"NES":0.83208,"nMoreExtreme":46611,"size":24,"leadingEdge":["ICAM1","TGFB1","CFLAR","ASS1"]} {"pathway":"GO_CRANIAL_NERVE_DEVELOPMENT","pval":0.73978,"padj":0.95899,"ES":0.58922,"NES":0.83174,"nMoreExtreme":48429,"size":31,"leadingEdge":["EGR2","TIFAB","LPAR1","TBX1","NEUROG1","SEMA3F","SIX1"]} {"pathway":"GO_DETERMINATION_OF_ADULT_LIFESPAN","pval":0.75908,"padj":0.9603,"ES":0.65341,"NES":0.83153,"nMoreExtreme":44679,"size":14,"leadingEdge":["LRRK2","CGAS"]} {"pathway":"GO_ATP_HYDROLYSIS_COUPLED_CATION_TRANSMEMBRANE_TRANSPORT","pval":0.75267,"padj":0.9603,"ES":0.55725,"NES":0.83142,"nMoreExtreme":52075,"size":44,"leadingEdge":["ATP13A2","ATP6V1A","ATP2C1"]} {"pathway":"GO_REGULATION_OF_GLYCOPROTEIN_BIOSYNTHETIC_PROCESS","pval":0.7425,"padj":0.95912,"ES":0.58255,"NES":0.83119,"nMoreExtreme":49081,"size":33,"leadingEdge":["IL15","SOAT1","JAK3","CCL19","PLCB1"]} {"pathway":"GO_RESPONSE_TO_STILBENOID","pval":0.75519,"padj":0.9603,"ES":0.62353,"NES":0.83108,"nMoreExtreme":37787,"size":1,"leadingEdge":["CD36"]} {"pathway":"GO_OTOLITH_DEVELOPMENT","pval":0.56369,"padj":0.93517,"ES":0.56395,"NES":0.83086,"nMoreExtreme":28816,"size":3,"leadingEdge":["ATG5","LRIG3","LRIG1"]} {"pathway":"GO_SUPRAMOLECULAR_FIBER_ORGANIZATION","pval":0.94021,"padj":0.98812,"ES":0.45752,"NES":0.83078,"nMoreExtreme":91503,"size":567,"leadingEdge":["PSTPIP2","PLEK","MSRB1","JAK2","SPTBN4","ICAM1","SCIN","XIRP1","TMSB10","EDN1","FAM107A","RHOBTB3","S100A10","COMP","PTGER4","PPM1E","RND1","ARHGAP25","DES","CD47","CXCL12","ACTR3C","RHOH","PAK1","SRC","ARHGAP17","CDC42EP2","CCDC88B","STMN3","STMND1","PDGFRA","RHOQ","ACTN2","MAP2","LPAR1","TPPP","CX3CL1","FOXC1","AP1AR","CFLAR","PPARGC1B","SMAD3","SPTA1","SLIT2","MYOZ1","C9orf72","MARCKS"]} {"pathway":"GO_RAS_PROTEIN_SIGNAL_TRANSDUCTION","pval":0.91552,"padj":0.987,"ES":0.46147,"NES":0.83037,"nMoreExtreme":86768,"size":395,"leadingEdge":["JAK2","RASGRF1","RAPGEF2","RAB20","RALB","RHOBTB3","MRAS","BCL6","LYN","CSF1","RND1","ARHGEF3","FGF10","NOTCH2","GPR18","RASGRP1","F2RL2","FARP2","RAB24","FGD2","NTN1","RHOH","AUTS2","SH2B2","RALGDS","IQSEC3","CDC42EP2","ROBO1","STMN3","CDKN1A","RHOQ","LPAR1","RIPOR2","RAB38","FGD6","RAB39A","CDC42SE2","NGF","ARHGEF11","FLOT1","HEG1","RAB2B","GPR35","MET","MCF2","GRAP","LIMK1","MAPK11","RAB43"]} {"pathway":"GO_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY","pval":0.77781,"padj":0.96098,"ES":0.52633,"NES":0.83029,"nMoreExtreme":57371,"size":67,"leadingEdge":["GRIN3A","GRM8","RASGRF1","ANXA3","ACTN2","CX3CL1","RGS9","PLCB1","SHISA7","ARC","MAPK8IP2"]} {"pathway":"GO_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION","pval":0.92773,"padj":0.98702,"ES":0.45894,"NES":0.82998,"nMoreExtreme":89191,"size":470,"leadingEdge":["GBP1","LRRK2","ATP13A2","IFI27","ZC3H12A","CYLD","RALB","DTX3L","PMAIP1","NUCB1","PYHIN1","PARP9","EDEM1","STAC3","LILRB4","TXN","TNF","KCNE1","PAK1","SRC","TGFB1","PTPN1","RHOQ","ACTN2","MAP2","GPM6B","PTGS2","RIPOR2","GAS6","PARL","ANKRD13A","BBC3","SMAD3","STX3","GAS8","STOM","PRR5L","FCER1G","TRIM46","SHISA7","ARC","GCC2","RUFY3"]} {"pathway":"GO_TENDON_DEVELOPMENT","pval":0.69789,"padj":0.94995,"ES":0.62054,"NES":0.82977,"nMoreExtreme":37455,"size":6,"leadingEdge":["COMP","COL11A1"]} {"pathway":"GO_V_D_J_RECOMBINATION","pval":0.76581,"padj":0.96082,"ES":0.65483,"NES":0.82922,"nMoreExtreme":44173,"size":12,"leadingEdge":["POLB","LIG4","TCF3"]} {"pathway":"GO_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION","pval":0.93551,"padj":0.98762,"ES":0.45767,"NES":0.82901,"nMoreExtreme":90383,"size":505,"leadingEdge":["AMOT","TAGAP","JAK2","ARAP2","RASGRF1","RAPGEF2","RAB20","RALB","RHOBTB3","MRAS","BCL6","LYN","CSF1","RND1","ARHGEF3","ARHGAP25","RASGEF1B","FGF10","NOTCH2","GPR18","RASGRP1","F2RL2","FARP2","RAB24","FGD2","NTN1","RHOH","AUTS2","SH2B2","RALGDS","SRC","ARHGAP17","A2M","IQSEC3","CDC42EP2","ROBO1","STMN3","CDKN1A","RRAGC","RHOQ","LPAR1","RIPOR2","RAB38","FGD6","RAB39A","CDC42SE2","SLIT2","NGF","ARHGEF11","FLOT1","HEG1","RAB2B","GPR35","MET","MCF2","GRAP","LIMK1","MAPK11","RAB43"]} {"pathway":"GO_REGULATION_OF_CGMP_MEDIATED_SIGNALING","pval":0.76625,"padj":0.96082,"ES":0.65446,"NES":0.82875,"nMoreExtreme":43752,"size":11,"leadingEdge":["NPR1","GUCA1A","CGAS"]} {"pathway":"GO_PROTEIN_DEPOLYMERIZATION","pval":0.80763,"padj":0.96828,"ES":0.50452,"NES":0.82857,"nMoreExtreme":63124,"size":97,"leadingEdge":["PLEK","SPTBN4","SCIN","STMN3","STMND1","ACTN2","SPTA1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_LOCOMOTION","pval":0.88711,"padj":0.98086,"ES":0.46841,"NES":0.82836,"nMoreExtreme":80391,"size":265,"leadingEdge":["CHRD","PADI2","KLF4","IFITM1","PML","STAP1","MIR503","SLAMF8","PTGER4","PTPRU","SEMA7A","DUSP10","MIIP","GPR18","CXCL12","CCL2","STAT3","PTPN2","TGFB1","SEMA4A","ROBO1","TRIM21","ADGRB1","RIPOR2","CX3CL1","TRIM25","AP1AR","GATA3","NFE2L2","IL33","MIR212","SEMA4D","PLCB1","SLIT2"]} {"pathway":"GO_G_PROTEIN_COUPLED_PURINERGIC_RECEPTOR_SIGNALING_PATHWAY","pval":0.74279,"padj":0.95933,"ES":0.6186,"NES":0.82819,"nMoreExtreme":46477,"size":22,"leadingEdge":["P2RY14","P2RY13","PTAFR","P2RY12","P2RY2","ACPP","GPR171","ADORA2A"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_MITOCHONDRION","pval":0.83139,"padj":0.97439,"ES":0.4897,"NES":0.82794,"nMoreExtreme":68349,"size":133,"leadingEdge":["LRRK2","BCL2L11","PMAIP1","PARL","BBC3"]} {"pathway":"GO_PEPTIDYL_LYSINE_OXIDATION","pval":0.65605,"padj":0.94878,"ES":0.60182,"NES":0.82785,"nMoreExtreme":34713,"size":5,"leadingEdge":["LOX","LOXL3","LOXL1","LOXL2","LOXL4"]} {"pathway":"GO_MULTI_ORGANISM_REPRODUCTIVE_PROCESS","pval":0.95217,"padj":0.99283,"ES":0.45457,"NES":0.82774,"nMoreExtreme":93474,"size":648,"leadingEdge":["IDO1","LRRK2","CD38","APOL2","ACOD1","SSTR2","LIMK2","AGT","OVOL1","PZP","CYP1A1","SPTBN4","PAQR8","BCL2L11","HORMAD1","SPATA9","EDN1","NRK","PIWIL4","IGF2R","MAFF","CLIC5","BCL6","TDRD9","TNFAIP6","NPM2","ZMYND15","BIRC3","PLA2G4C","AURKC","SOX8","TEX14","VGF","MEI1","AZIN2","UBE2A","NCOA1","CYP27B1","IGSF8","PTAFR","INSL4","STAT3","SRC","TGFB1","PARP11","CCR6","UCP2","NAMPT","HVCN1","PTGS2","NME8","PLPP1","FOXC1","TDRD7","LIN28A","CCNA1","SPINK1","PLCB1"]} {"pathway":"GO_PROTEIN_HOMOTRIMERIZATION","pval":0.74204,"padj":0.95912,"ES":0.61021,"NES":0.8276,"nMoreExtreme":46994,"size":24,"leadingEdge":["STEAP4","HLA-G","MLKL"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_GROWTH","pval":0.86993,"padj":0.97681,"ES":0.47345,"NES":0.82743,"nMoreExtreme":76557,"size":213,"leadingEdge":["AGT","PML","NPR1","MT2A","BCL6","LTA","MT1M","SEMA7A","NOTCH2","TNF","DUSP10","MT1E","NTN1","CYP27B1","PAK1","TGFB1","SEMA4A","CDKN1A","MT1H","MAP2","MT1G","SEMA4D","SMAD3","SLIT2","MYOZ1","TRIM46","IRF8","PLAC8","MAPK11","SEMA3F","BST2","SEMA3E","WWC3","DCSTAMP"]} {"pathway":"GO_DIENCEPHALON_DEVELOPMENT","pval":0.75896,"padj":0.9603,"ES":0.55254,"NES":0.82725,"nMoreExtreme":52691,"size":45,"leadingEdge":["HESX1","FGF10","TBX19","NCOA1","NR4A2","ALDH1A2","HAP1","SOX2","PTN","WNT1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_ACETYLATION","pval":0.75132,"padj":0.9603,"ES":0.57166,"NES":0.82706,"nMoreExtreme":50329,"size":36,"leadingEdge":["MUC1","AUTS2","TGFB1","GATA3","SNAI2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC","pval":0.76452,"padj":0.96082,"ES":0.54728,"NES":0.82698,"nMoreExtreme":53527,"size":48,"leadingEdge":["PADI2","TAF1A","BAZ1B"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TRANSPORTER_ACTIVITY","pval":0.7776,"padj":0.96098,"ES":0.52988,"NES":0.82633,"nMoreExtreme":56512,"size":61,"leadingEdge":["CAMK2D","SRI","DYSF","KCNE5","GEM","KCNE1","ACTN2","MIR212","CLIC2","KCNE1B","GPR35"]} {"pathway":"GO_RESPONSE_TO_AMMONIUM_ION","pval":0.80022,"padj":0.96646,"ES":0.51091,"NES":0.82572,"nMoreExtreme":61035,"size":83,"leadingEdge":["LRRK2","CASP7","PTAFR","PLCB1","ASS1"]} {"pathway":"GO_RESPONSE_TO_GROWTH_HORMONE","pval":0.74632,"padj":0.96025,"ES":0.59361,"NES":0.82494,"nMoreExtreme":48210,"size":28,"leadingEdge":["JAK2","JAK3","LYN","STAT5A","STAT3","PTPN1","ASS1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PRI_MIRNA_TRANSCRIPTION_BY_RNA_POLYMERASE_II","pval":0.74544,"padj":0.96025,"ES":0.59695,"NES":0.82457,"nMoreExtreme":47931,"size":27,"leadingEdge":["STAT3","TGFB1","PDGFB","SMAD3","NGFR"]} {"pathway":"GO_POSITIVE_REGULATION_OF_BLOOD_VESSEL_REMODELING","pval":0.76644,"padj":0.96082,"ES":0.61814,"NES":0.8239,"nMoreExtreme":38350,"size":1,"leadingEdge":["TMBIM1"]} {"pathway":"GO_SUCKLING_BEHAVIOR","pval":0.75963,"padj":0.96046,"ES":0.64475,"NES":0.82355,"nMoreExtreme":42450,"size":9,"leadingEdge":["GLS","DERL2"]} {"pathway":"GO_HEART_INDUCTION","pval":0.69993,"padj":0.94995,"ES":0.61553,"NES":0.82307,"nMoreExtreme":37564,"size":6,"leadingEdge":["ROBO1","DKK1"]} {"pathway":"GO_EPIDERMAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY","pval":0.82115,"padj":0.97273,"ES":0.49707,"NES":0.82301,"nMoreExtreme":65129,"size":105,"leadingEdge":["CEACAM1","AGT","NCF1","GAREM1","PTPN2","SRC","TGFB1","RHBDF2","IFI6","EREG","RNF115","HAP1"]} {"pathway":"GO_REGULATION_OF_VITAMIN_METABOLIC_PROCESS","pval":0.77019,"padj":0.96082,"ES":0.64977,"NES":0.82281,"nMoreExtreme":43977,"size":11,"leadingEdge":["TNF","CYP27B1","SNAI2"]} {"pathway":"GO_B_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE","pval":0.78974,"padj":0.96445,"ES":0.52244,"NES":0.82266,"nMoreExtreme":58103,"size":66,"leadingEdge":["CD40","TBX21","BCL6","PARP3","NOTCH2","PTPRC","NBN","TGFB1","CCR6","LIG4"]} {"pathway":"GO_ADIPONECTIN_ACTIVATED_SIGNALING_PATHWAY","pval":0.73054,"padj":0.95646,"ES":0.62886,"NES":0.82259,"nMoreExtreme":39708,"size":7,"leadingEdge":["ACSL1","ADIPOR2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MONOOXYGENASE_ACTIVITY","pval":0.75018,"padj":0.9603,"ES":0.61423,"NES":0.82233,"nMoreExtreme":46939,"size":22,"leadingEdge":["GCH1","TNF","S100A1"]} {"pathway":"GO_REGULATION_OF_HORMONE_SECRETION","pval":0.86732,"padj":0.97662,"ES":0.47537,"NES":0.82232,"nMoreExtreme":74625,"size":181,"leadingEdge":["CD38","HCAR2","JAK2","AGT","SIDT2","SRI","EDN1","CCL5","GLUL","TNF","UCP2","NKX3-1","NADK","ILDR1","CPT1A","PIM3","ADORA2A"]} {"pathway":"GO_LYMPHANGIOGENESIS","pval":0.76761,"padj":0.96082,"ES":0.64615,"NES":0.82229,"nMoreExtreme":45181,"size":14,"leadingEdge":["VEGFC","FOXC1","PROX1","FLT4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION_INVOLVED_IN_WOUND_HEALING","pval":0.65739,"padj":0.94878,"ES":0.59772,"NES":0.82222,"nMoreExtreme":34784,"size":5,"leadingEdge":["FGF10","B4GALT1"]} {"pathway":"GO_MITOCHONDRIAL_TRANSCRIPTION","pval":0.76512,"padj":0.96082,"ES":0.64324,"NES":0.82183,"nMoreExtreme":45465,"size":15,"leadingEdge":["PPARGC1B","POLRMT"]} {"pathway":"GO_INFLAMMATORY_RESPONSE_TO_WOUNDING","pval":0.76852,"padj":0.96082,"ES":0.6472,"NES":0.82164,"nMoreExtreme":43379,"size":10,"leadingEdge":["TGFB1","IL1A","GRN"]} {"pathway":"GO_ADRENAL_GLAND_DEVELOPMENT","pval":0.7542,"padj":0.9603,"ES":0.62222,"NES":0.82146,"nMoreExtreme":46620,"size":20,"leadingEdge":["ASCL1","PDGFRA","CDKN1C","SMAD3","ARID5B","DKK3"]} {"pathway":"GO_AXO_DENDRITIC_TRANSPORT","pval":0.78593,"padj":0.96311,"ES":0.52672,"NES":0.82141,"nMoreExtreme":57117,"size":61,"leadingEdge":["DTNBP1","MAP2","TRIM46","HAP1","KIF17","PAFAH1B1"]} {"pathway":"GO_EXOCRINE_SYSTEM_DEVELOPMENT","pval":0.76258,"padj":0.96082,"ES":0.55977,"NES":0.82034,"nMoreExtreme":51796,"size":39,"leadingEdge":["HGF","TGM2","POLB","FGF10","TNF","TGFB1","FOXC1","NKX3-1"]} {"pathway":"GO_VESICLE_MEDIATED_TRANSPORT_BETWEEN_ENDOSOMAL_COMPARTMENTS","pval":0.76523,"padj":0.96082,"ES":0.55773,"NES":0.82022,"nMoreExtreme":52161,"size":40,"leadingEdge":["LMTK2","SRC","SNX16","DNAJC13","RILP"]} {"pathway":"GO_FATTY_ACID_TRANSPORT","pval":0.79417,"padj":0.96574,"ES":0.52083,"NES":0.82013,"nMoreExtreme":58429,"size":66,"leadingEdge":["P2RX7","ACSL1","P2RX4","EDN1","SLC27A3","PLA2G4A","MFSD2A","CPT1A","FABP4"]} {"pathway":"GO_RESPONSE_TO_EPIDERMAL_GROWTH_FACTOR","pval":0.76815,"padj":0.96082,"ES":0.55367,"NES":0.81995,"nMoreExtreme":52674,"size":42,"leadingEdge":["GAREM1","ASCL1","FOXC1","CFLAR","ZFP36","SNAI2"]} {"pathway":"GO_REGULATION_OF_CELL_DEVELOPMENT","pval":0.96951,"padj":0.99625,"ES":0.44923,"NES":0.81984,"nMoreExtreme":95813,"size":760,"leadingEdge":["ASCL2","GBP1","LRRK2","CD38","HGF","KREMEN1","AGT","BHLHE41","KLF4","SCARF1","B2M","P2RX4","RAPGEF2","STAP1","EDN1","VEGFC","C21orf91","S100A10","SLAMF8","DYNLT1","BCL6","LYN","CSF1","LTA","NRCAM","CTSZ","IL6","SEMA7A","NOTCH2","TNF","SOX8","DUSP10","CAMK1D","MOV10","NCOA1","ASCL1","NTN1","CXCL12","LILRB1","STAT3","P2RY12","PAK1","TGIF2","TGFB1","SEMA4A","ROBO1","ISL2","MAP2","RGMA","LIG4","LPAR1","HAS2","CCL3","CX3CL1","AP1AR","CFLAR","GATA3","NFE2L2","SRCIN1","LIN28A","SEMA4D"]} {"pathway":"GO_REGULATION_OF_TYPE_B_PANCREATIC_CELL_DEVELOPMENT","pval":0.73166,"padj":0.95656,"ES":0.62605,"NES":0.81892,"nMoreExtreme":39769,"size":7,"leadingEdge":["BAD","RFX3","GSK3B","GSK3A","RHEB","ARNTL","CLOCK"]} {"pathway":"GO_MHC_CLASS_II_BIOSYNTHETIC_PROCESS","pval":0.76989,"padj":0.96082,"ES":0.64499,"NES":0.81884,"nMoreExtreme":43456,"size":10,"leadingEdge":["CIITA","TLR4"]} {"pathway":"GO_REGULATION_OF_ATRIAL_CARDIAC_MUSCLE_CELL_MEMBRANE_REPOLARIZATION","pval":0.65814,"padj":0.94878,"ES":0.59524,"NES":0.8188,"nMoreExtreme":34824,"size":5,"leadingEdge":["KCNE5","KCNQ1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_LIPID_LOCALIZATION","pval":0.79353,"padj":0.96526,"ES":0.52273,"NES":0.81819,"nMoreExtreme":57958,"size":63,"leadingEdge":["P2RX7","C3","ZC3H12A","P2RX4","EDN1","LIPG","NR1H3","IKBKE","NFKBIA","PRELID1","NKX3-1"]} {"pathway":"GO_REGULATION_OF_TOLL_LIKE_RECEPTOR_9_SIGNALING_PATHWAY","pval":0.73208,"padj":0.95661,"ES":0.62549,"NES":0.81818,"nMoreExtreme":39792,"size":7,"leadingEdge":["RSAD2","LILRA4","PTPRS"]} {"pathway":"GO_SENSORY_SYSTEM_DEVELOPMENT","pval":0.90445,"padj":0.98417,"ES":0.46233,"NES":0.81795,"nMoreExtreme":82047,"size":267,"leadingEdge":["LIMK2","CYP1A1","KLF4","C3","SCO2","CTNS","FGF10","SOX8","SLC25A25","STAT3","P2RY12","TGIF2","TGFB1","VAX2","PDGFRA","CDKN1C","GPD2","FOXC1","GATA3","TDRD7","SMAD3","BAK1","RAB11FIP4","RORB","COL8A2","ALDH1A2","PROX1","SOX2","PTN"]} {"pathway":"GO_NON_RECOMBINATIONAL_REPAIR","pval":0.80944,"padj":0.96934,"ES":0.5087,"NES":0.8179,"nMoreExtreme":61283,"size":79,"leadingEdge":["DTX3L","POLB","PARP3","PARP9","NBN","UVRAG","LIG4"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_AMINO_ACID_STIMULUS","pval":0.79426,"padj":0.96574,"ES":0.52246,"NES":0.81777,"nMoreExtreme":58011,"size":63,"leadingEdge":["SOCS1","TNF","GCLC","PDGFRA","RRAGC","RRAGD","UBR1","ASS1","SIX1"]} {"pathway":"GO_RESPONSE_TO_AUDITORY_STIMULUS","pval":0.76889,"padj":0.96082,"ES":0.6398,"NES":0.81743,"nMoreExtreme":45689,"size":15,"leadingEdge":["CXCL10","TIFAB","NEUROG1"]} {"pathway":"GO_REGULATION_OF_PROTEIN_EXPORT_FROM_NUCLEUS","pval":0.76768,"padj":0.96082,"ES":0.55748,"NES":0.81699,"nMoreExtreme":52142,"size":39,"leadingEdge":["IFI27","TXN","GAS6","AKAP8L"]} {"pathway":"GO_MUSCLE_ORGAN_DEVELOPMENT","pval":0.91847,"padj":0.987,"ES":0.45843,"NES":0.81689,"nMoreExtreme":84836,"size":309,"leadingEdge":["VAMP5","CXCL10","EGR2","ATF3","PIM1","ITGA7","SRI","EDN1","MAFF","ASB2","MRAS","TIFAB","MYH7","STAC3","EGR3","SOX8","TRIM72","IGSF8","PAK1","TGFB1","ADGRB1","RIPOR2","FOXC1","CFLAR","SMAD3","NUPR1","MYOZ1","FOXN2","ZBTB42","PAX5","HLX","ARID5B","FLOT1","HEG1","ASS1","TBX1","PROX1","MAPK11","NEUROG1","BTG2"]} {"pathway":"GO_TUBE_DEVELOPMENT","pval":0.97568,"padj":0.99825,"ES":0.44713,"NES":0.81675,"nMoreExtreme":96709,"size":831,"leadingEdge":["CD40","CXCL10","CEACAM1","TNFAIP2","AMOT","HGF","CHRD","STAT1","AGT","TYMP","CYP1A1","KLF4","BCL2L11","DNAAF1","TGM2","PML","C3","ZC3H12A","RAPGEF2","HSD11B1","NPR1","ENPP2","EDN1","VEGFC","MIR503","SAT1","COMP","DYSF","HLA-G","GLUL","CSF1","NR4A3","NRCAM","PRKX","TNFAIP3","ANXA3","RNF207","CTSZ","IL6","TLR3","FGF10","EGR3","TNF","SOX8","FLT1","ADM2","SMPD3","ASCL1","NTN1","CHI3L1","F3","CCL2","STAT3","PAK1","TRIM71","MYO1E","ANGPTL4","PODXL","RUNX1","SRC","TGFB1","SEMA4A","ROBO1","CXCL8","CDKN1A","PDGFRA","ADGRB1","PTGS2","HAS2","CX3CL1","FOXC1","TNS3","ESM1","GATA3","NKX3-1","NFE2L2","MIR212","ERAP1","SMAD3","CRISPLD2","SLIT2","BAK1","IL1A","HLX","HOXD11","EDNRA","COL8A2","PPP1R16B","S100A1","HEG1","GPR161"]} {"pathway":"GO_POSITIVE_REGULATION_OF_VIRAL_LIFE_CYCLE","pval":0.79117,"padj":0.96486,"ES":0.52945,"NES":0.81623,"nMoreExtreme":56601,"size":56,"leadingEdge":["CD74","CHMP4C","CCL5","TRIM21","ADAR","STOM"]} {"pathway":"GO_REGULATION_OF_AORTA_MORPHOGENESIS","pval":0.61272,"padj":0.94703,"ES":0.54712,"NES":0.81607,"nMoreExtreme":30790,"size":2,"leadingEdge":["EFNB2","NOTCH1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_INFLAMMATORY_RESPONSE","pval":0.77447,"padj":0.96098,"ES":0.64379,"NES":0.8158,"nMoreExtreme":45105,"size":13,"leadingEdge":["MEFV","ZC3H12A","IL1R2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELL_JUNCTION_ASSEMBLY","pval":0.76076,"padj":0.96082,"ES":0.58061,"NES":0.81548,"nMoreExtreme":49593,"size":30,"leadingEdge":["AGT","S100A10","SMAD3","FLOT1"]} {"pathway":"GO_BONE_GROWTH","pval":0.76696,"padj":0.96082,"ES":0.56364,"NES":0.81545,"nMoreExtreme":51377,"size":36,"leadingEdge":["COMP","SMPD3","COCH","COL27A1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELL_JUNCTION_ASSEMBLY","pval":0.75911,"padj":0.9603,"ES":0.60907,"NES":0.81543,"nMoreExtreme":47498,"size":22,"leadingEdge":["FAM107A","TNF","SRC","ROCK1"]} {"pathway":"GO_REGULATION_OF_COLLAGEN_FIBRIL_ORGANIZATION","pval":0.65901,"padj":0.94878,"ES":0.59272,"NES":0.81533,"nMoreExtreme":34870,"size":5,"leadingEdge":["CHADL","AEBP1","COLGALT1","EMILIN1","RB1"]} {"pathway":"GO_GROWTH","pval":0.97503,"padj":0.99814,"ES":0.44646,"NES":0.81522,"nMoreExtreme":96521,"size":794,"leadingEdge":["SOCS1","CD38","CEACAM1","AGT","PIM1","CAMK2D","SPTBN4","BCL2L11","PML","ATF5","NPR1","EDN1","NRK","FAM107A","CISH","MT2A","COMP","COLQ","DYSF","BCL6","CSF1","LTA","IL7","NRCAM","CXCL16","FGF10","MT1M","SEMA7A","NOTCH2","CHST11","TNF","STAT5A","HPN","DUSP10","MT1E","SMPD3","NTN1","CXCL12","CYP27B1","SLC25A25","SLC4A10","AUTS2","SOCS3","STAT3","NBN","PAK1","SRC","TGFB1","SEMA4A","CDKN1A","MT1H","CDKN1C","OGFR","CREG1","MAP2","GPD2","GAS6","FOXC1","CFLAR","GATA3","MT1G","SEMA4D","PLCB1","SMAD3","SYT17","SLIT2","MYOZ1","TRIM46","HLX","NGF","C9orf72","ARHGEF11","ARID5B","IRF8","HEG1","RUFY3","EREG","COBL","PLAC8","PROX1","CLSTN3","SOX2","LIMK1","COCH","MAPK11","SEMA3F","COL27A1","HNF1B"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_AMMONIUM_ION","pval":0.77875,"padj":0.96098,"ES":0.54262,"NES":0.81508,"nMoreExtreme":54203,"size":46,"leadingEdge":["LRRK2","CASP7","PTAFR","PLCB1","ASS1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_NEURON_PROJECTION_REGENERATION","pval":0.77311,"padj":0.96098,"ES":0.64044,"NES":0.81503,"nMoreExtreme":45505,"size":14,"leadingEdge":["KREMEN1","RGMA","RTN4R"]} {"pathway":"GO_POLYSACCHARIDE_BIOSYNTHETIC_PROCESS","pval":0.80013,"padj":0.96646,"ES":0.5196,"NES":0.81489,"nMoreExtreme":58594,"size":64,"leadingEdge":["B4GALT5","SMPD3","TGFB1","HAS2","PDGFB","ESRRB","IGF1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION","pval":0.76306,"padj":0.96082,"ES":0.62571,"NES":0.81489,"nMoreExtreme":46425,"size":18,"leadingEdge":["PML","MEFV","ZC3H12A","CARD17","CARD16","TNFAIP3","CX3CL1"]} {"pathway":"GO_HEART_FORMATION","pval":0.7591,"padj":0.9603,"ES":0.60396,"NES":0.81389,"nMoreExtreme":47760,"size":23,"leadingEdge":["PIM1","ROBO1","SMARCD3","SIX1"]} {"pathway":"GO_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT","pval":0.80422,"padj":0.96671,"ES":0.51662,"NES":0.81349,"nMoreExtreme":59169,"size":66,"leadingEdge":["LRRK2","C21orf91","LPAR1","SRCIN1","ARC"]} {"pathway":"GO_POSITIVE_REGULATION_OF_RESPONSE_TO_TUMOR_CELL","pval":0.75215,"padj":0.9603,"ES":0.62985,"NES":0.81295,"nMoreExtreme":41443,"size":8,"leadingEdge":["CD274","IL12A","CD226"]} {"pathway":"GO_INTERLEUKIN_13_PRODUCTION","pval":0.76524,"padj":0.96082,"ES":0.62413,"NES":0.81284,"nMoreExtreme":46558,"size":18,"leadingEdge":["HLA-E","IRF4","GATA3","IL33","LILRA5","IFNL1"]} {"pathway":"GO_MEMBRANE_DEPOLARIZATION_DURING_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL","pval":0.76473,"padj":0.96082,"ES":0.61958,"NES":0.81244,"nMoreExtreme":46967,"size":19,"leadingEdge":["KCNJ2","ANK2","SLC8A1","CACNA1G"]} {"pathway":"GO_POSITIVE_REGULATION_OF_HETEROTYPIC_CELL_CELL_ADHESION","pval":0.76532,"padj":0.96082,"ES":0.63602,"NES":0.81239,"nMoreExtreme":42768,"size":9,"leadingEdge":["TNF","FLOT1","CD44"]} {"pathway":"GO_CELL_ADHESION_MEDIATED_BY_INTEGRIN","pval":0.79895,"padj":0.96646,"ES":0.52199,"NES":0.81237,"nMoreExtreme":57912,"size":60,"leadingEdge":["ICAM1","MUC1","CCL5","LYN","P2RY12","ITGB7","PODXL"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS","pval":0.77689,"padj":0.96098,"ES":0.64101,"NES":0.81227,"nMoreExtreme":45246,"size":13,"leadingEdge":["CEACAM1","ERLIN1","INSIG2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT","pval":0.78186,"padj":0.96269,"ES":0.54429,"NES":0.81208,"nMoreExtreme":54094,"size":44,"leadingEdge":["ICAM1","SRI","DYSF","GEM","LILRB1","TGFB1","PTGS2","SPINK1","CLIC2","GPR35","LILRB2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION_INVOLVED_IN_LUNG_MORPHOGENESIS","pval":0.6599,"padj":0.94905,"ES":0.59008,"NES":0.8117,"nMoreExtreme":34917,"size":5,"leadingEdge":["FGFR2","WNT2","SRSF6","FOXP2","FGF7"]} {"pathway":"GO_BENZENE_CONTAINING_COMPOUND_METABOLIC_PROCESS","pval":0.76562,"padj":0.96082,"ES":0.63547,"NES":0.81169,"nMoreExtreme":42785,"size":9,"leadingEdge":["KMO","AADAT"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY","pval":0.76934,"padj":0.96082,"ES":0.62764,"NES":0.81168,"nMoreExtreme":46490,"size":17,"leadingEdge":["LRRK2","CYP27B1","MIR212"]} {"pathway":"GO_POST_EMBRYONIC_ANIMAL_ORGAN_MORPHOGENESIS","pval":0.75276,"padj":0.9603,"ES":0.6287,"NES":0.81147,"nMoreExtreme":41477,"size":8,"leadingEdge":["BCL2L11","BAK1"]} {"pathway":"GO_EAR_MORPHOGENESIS","pval":0.82411,"padj":0.97439,"ES":0.5028,"NES":0.81144,"nMoreExtreme":62707,"size":82,"leadingEdge":["EDN1","TIFAB","NR4A3","FGF10","HPN","NTN1","GATA3","PDZD7","INSIG2","TBX1","PROX1","NEUROG1","WNT1","SIX1"]} {"pathway":"GO_SYNAPSE_PRUNING","pval":0.77437,"padj":0.96098,"ES":0.63842,"NES":0.81049,"nMoreExtreme":43709,"size":10,"leadingEdge":["C1QB","C3","C1QC","CX3CL1"]} {"pathway":"GO_REGULATION_OF_GENE_SILENCING","pval":0.84185,"padj":0.97458,"ES":0.48993,"NES":0.81047,"nMoreExtreme":66671,"size":104,"leadingEdge":["ZC3H12A","STAT3","TRIM71","TGFB1","LIN28A","ZFP36","POLR2J"]} {"pathway":"GO_NEPHRON_DEVELOPMENT","pval":0.85184,"padj":0.97645,"ES":0.48507,"NES":0.81042,"nMoreExtreme":68562,"size":116,"leadingEdge":["STAT1","AGT","SOX8","MYO1E","PODXL","TGFB1","PDGFRA","FOXC1","CFLAR","GATA3","PDGFB","HOXD11","WNT1","HNF1B","SIX1"]} {"pathway":"GO_SYNAPTIC_VESICLE_ENDOSOMAL_PROCESSING","pval":0.73499,"padj":0.95787,"ES":0.61942,"NES":0.81025,"nMoreExtreme":39950,"size":7,"leadingEdge":["AP3D1","GRIPAP1","DNM1L","EEA1","VAMP4","AP3B1","STX6"]} {"pathway":"GO_EPITHELIAL_TUBE_MORPHOGENESIS","pval":0.91816,"padj":0.987,"ES":0.4576,"NES":0.81014,"nMoreExtreme":83432,"size":271,"leadingEdge":["CXCL10","AGT","DNAAF1","PML","EDN1","CSF1","PRKX","RNF207","CTSZ","FGF10","TNF","SOX8","NTN1","PAK1","TRIM71","PODXL","SRC","TGFB1","GATA3","NKX3-1","SMAD3","SLIT2","HOXD11","EDNRA","MTHFR","COBL","MET","PROX1","WNT1","HNF1B","PRICKLE1","SEMA3E","LAMA1","SIX1"]} {"pathway":"GO_CYTOPLASMIC_SEQUESTERING_OF_TRANSCRIPTION_FACTOR","pval":0.77073,"padj":0.96084,"ES":0.62626,"NES":0.80989,"nMoreExtreme":46574,"size":17,"leadingEdge":["SRI","NFKBIA","NFKBIE","PKD1"]} {"pathway":"GO_METANEPHRIC_NEPHRON_TUBULE_MORPHOGENESIS","pval":0.70401,"padj":0.9504,"ES":0.60524,"NES":0.80932,"nMoreExtreme":37783,"size":6,"leadingEdge":["SOX8","PKD1"]} {"pathway":"GO_REGULATION_OF_PEPTIDYL_LYSINE_ACETYLATION","pval":0.79943,"padj":0.96646,"ES":0.52711,"NES":0.80917,"nMoreExtreme":56904,"size":54,"leadingEdge":["MUC1","AUTS2","TGFB1","GATA3","SNAI2"]} {"pathway":"GO_CARBOHYDRATE_BIOSYNTHETIC_PROCESS","pval":0.88344,"padj":0.98086,"ES":0.47039,"NES":0.80912,"nMoreExtreme":75214,"size":167,"leadingEdge":["PLEK","ATF3","DGAT2","B4GALT5","CHST11","SMPD3","PTAFR","PTPN2","TGFB1","HAS2","GPD2","PDGFB","SIK1","ESRRB","CD244","SDS"]} {"pathway":"GO_REGULATION_OF_FAT_CELL_DIFFERENTIATION","pval":0.84316,"padj":0.97458,"ES":0.491,"NES":0.80808,"nMoreExtreme":66146,"size":99,"leadingEdge":["ZC3H12A","IL6","TNF","DUSP10","TGFB1","SORT1","PTGS2","GATA3","SMAD3","ZFP36","WNT1"]} {"pathway":"GO_LUNG_VASCULATURE_DEVELOPMENT","pval":0.70473,"padj":0.95065,"ES":0.60393,"NES":0.80756,"nMoreExtreme":37822,"size":6,"leadingEdge":["FOXF1","ERRFI1","TCF21","ID1","LIF","STRA6"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY","pval":0.78005,"padj":0.96128,"ES":0.63764,"NES":0.80746,"nMoreExtreme":44540,"size":11,"leadingEdge":["PTPN2","NDRG4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NEURON_DEATH","pval":0.82962,"padj":0.97439,"ES":0.50081,"NES":0.80726,"nMoreExtreme":63031,"size":81,"leadingEdge":["BCL2L11","CTSZ","TNF","ASCL1","KMO","MCL1","CCL3","RAPSN","TLR4","HDAC4"]} {"pathway":"GO_HORMONE_METABOLIC_PROCESS","pval":0.87263,"padj":0.97746,"ES":0.47534,"NES":0.80723,"nMoreExtreme":72390,"size":141,"leadingEdge":["CYP1A1","HSD11B1","DHRS9","DGAT2","COLQ","CTSZ","TNF","HPN","CYP27B1","PDGFRA","CES1","GATA3","SCPEP1","NGF","ALDH1A2"]} {"pathway":"GO_ENDOTHELIAL_CELL_DEVELOPMENT","pval":0.79768,"padj":0.96646,"ES":0.52976,"NES":0.80723,"nMoreExtreme":56352,"size":51,"leadingEdge":["ICAM1","RAPGEF2","MARVELD2","TNF","PPP1R16B","HEG1","MET"]} {"pathway":"GO_TRANSCRIPTION_PREINITIATION_COMPLEX_ASSEMBLY","pval":0.78455,"padj":0.96311,"ES":0.54882,"NES":0.80713,"nMoreExtreme":53478,"size":40,"leadingEdge":["GTF2B","PSMC4"]} {"pathway":"GO_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT","pval":0.77857,"padj":0.96098,"ES":0.63131,"NES":0.80658,"nMoreExtreme":46264,"size":15,"leadingEdge":["STAT1","PRKX","GATA3","PROM1"]} {"pathway":"GO_RESPONSE_TO_CAMP","pval":0.82312,"padj":0.97429,"ES":0.5051,"NES":0.80636,"nMoreExtreme":61706,"size":74,"leadingEdge":["STAT1","RAPGEF2","SLC8A1","VGF","PTAFR","KCNE1","PPARGC1B","ASS1","JUNB","AQP9"]} {"pathway":"GO_GLUTATHIONE_DERIVATIVE_BIOSYNTHETIC_PROCESS","pval":0.7744,"padj":0.96098,"ES":0.62337,"NES":0.80616,"nMoreExtreme":46796,"size":17,"leadingEdge":["GSTK1","MGST1"]} {"pathway":"GO_REGULATION_OF_ARTERY_MORPHOGENESIS","pval":0.57732,"padj":0.94163,"ES":0.54715,"NES":0.80612,"nMoreExtreme":29513,"size":3,"leadingEdge":["AKT3","EFNB2","NOTCH1"]} {"pathway":"GO_HINDBRAIN_DEVELOPMENT","pval":0.85845,"padj":0.97645,"ES":0.48291,"NES":0.80609,"nMoreExtreme":68993,"size":115,"leadingEdge":["EGR2","SSTR2","ATF5","NCOA1","ASCL1","PAK1","LPAR1","SEZ6L","FOXC1","CKB","ALDH1A2","PROX1","HAP1","PTN","WNT1","HNF1B","RERE"]} {"pathway":"GO_T_CELL_MIGRATION","pval":0.79765,"padj":0.96646,"ES":0.5319,"NES":0.80592,"nMoreExtreme":55969,"size":49,"leadingEdge":["CXCL11","CXCL10","ICAM1","CCL5","TNFRSF14","CXCL16","CXCL12","CCL2","ITGB7","CCR6","RIPOR2","CCL3"]} {"pathway":"GO_THYROID_GLAND_DEVELOPMENT","pval":0.77789,"padj":0.96098,"ES":0.62718,"NES":0.80572,"nMoreExtreme":46597,"size":16,"leadingEdge":["FGF10","SMAD3","TBX1","SIX1"]} {"pathway":"GO_ORGANELLE_LOCALIZATION","pval":0.97183,"padj":0.99724,"ES":0.44258,"NES":0.80531,"nMoreExtreme":95163,"size":623,"leadingEdge":["P2RX7","LRRK2","PLEK","STX11","GRIN3A","ERC2","PRRT2","S100A13","RALB","CHMP4C","DYNLT1","LYN","DTNBP1","CADPS2","NR4A3","CTSZ","FGF10","MEI1","RASGRP1","NTN1","GEM","PSEN2","TUBA4A","TRIM9","SYT5","UVRAG","CTSC","MAP2","AP1AR","NAPA","STX3","SYT17","STX17","FCER1G","TRIM46"]} {"pathway":"GO_EPITHELIAL_TO_MESENCHYMAL_TRANSITION","pval":0.861,"padj":0.97645,"ES":0.48243,"NES":0.80422,"nMoreExtreme":69077,"size":113,"leadingEdge":["HGF","GLIPR2","IL6","HPN","TGFB1","HAS2","FOXC1","SMAD3"]} {"pathway":"GO_CARBOHYDRATE_METABOLIC_PROCESS","pval":0.95815,"padj":0.9934,"ES":0.44516,"NES":0.80421,"nMoreExtreme":91844,"size":452,"leadingEdge":["P2RX7","GK","PLEK","ATF3","MYOF","PMAIP1","DGAT2","DYSF","GCNT3","B4GALT5","CHST11","TNF","SMPD3","CHI3L1","PTAFR","ST3GAL5","STAT3","PTPN2","SRC","TGFB1","LDHAL6B","NAGK","HEXD","CHST2","HAS2","GPD2","FUT4","PDGFB","SIK1","ESRRB","GALM","CHI3L2","CPT1A","CD244","STBD1","SDS"]} {"pathway":"GO_ADENYLATE_CYCLASE_INHIBITING_ADRENERGIC_RECEPTOR_SIGNALING_PATHWAY","pval":0.62468,"padj":0.94878,"ES":0.53909,"NES":0.80409,"nMoreExtreme":31391,"size":2,"leadingEdge":["RGS2","ADRA2A"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELL_PROLIFERATION_INVOLVED_IN_KIDNEY_DEVELOPMENT","pval":0.61278,"padj":0.94703,"ES":0.56462,"NES":0.80404,"nMoreExtreme":31892,"size":4,"leadingEdge":["GATA3","FLCN"]} {"pathway":"GO_REPRODUCTIVE_BEHAVIOR","pval":0.77391,"padj":0.96098,"ES":0.60874,"NES":0.80366,"nMoreExtreme":47838,"size":20,"leadingEdge":["NCOA1","CREBRF","MAPK8IP2","HDAC4","ZFX"]} {"pathway":"GO_REGULATION_OF_EXTRACELLULAR_MATRIX_ASSEMBLY","pval":0.76972,"padj":0.96082,"ES":0.62911,"NES":0.80356,"nMoreExtreme":43014,"size":9,"leadingEdge":["AGT","TGFB1","HAS2","SMAD3"]} {"pathway":"GO_GLYCOPROTEIN_BIOSYNTHETIC_PROCESS","pval":0.93233,"padj":0.98762,"ES":0.45263,"NES":0.80335,"nMoreExtreme":85199,"size":285,"leadingEdge":["IL15","MUC1","SOAT1","JAK3","TMTC1","GCNT3","DSE","B4GALT5","CHST11","HS3ST3B1","ST3GAL5","TMTC2","CCL19","GALNT12","ST6GALNAC2","FUT4","HS3ST3A1","PLCB1","LMF1","SLC35C2","NPC1","HS3ST2"]} {"pathway":"GO_FATTY_ACID_BIOSYNTHETIC_PROCESS","pval":0.85977,"padj":0.97645,"ES":0.48294,"NES":0.80312,"nMoreExtreme":68669,"size":110,"leadingEdge":["CD74","CEACAM1","CYP1A1","EDN1","CBR1","NR1H3","ELOVL7","ACSS1","PTGS2","ACSM5","ERLIN1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_COAGULATION","pval":0.77492,"padj":0.96098,"ES":0.61243,"NES":0.80306,"nMoreExtreme":47593,"size":19,"leadingEdge":["PLEK","ENPP4","F3","NFE2L2","TLR4"]} {"pathway":"GO_RESPONSE_TO_AMPHETAMINE","pval":0.77232,"padj":0.96095,"ES":0.59581,"NES":0.80291,"nMoreExtreme":48592,"size":23,"leadingEdge":["ICAM1","NR4A2","RGS9","ADORA2A"]} {"pathway":"GO_POSITIVE_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION","pval":0.77473,"padj":0.96098,"ES":0.60812,"NES":0.80284,"nMoreExtreme":47889,"size":20,"leadingEdge":["CSF1","TNF","OCSTAMP","PPARGC1B","CCR1","TYROBP"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER","pval":0.77763,"padj":0.96098,"ES":0.62072,"NES":0.80272,"nMoreExtreme":46991,"size":17,"leadingEdge":["GTF2B","HNF1B","PSMC4"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_NEURON_DIFFERENTIATION","pval":0.9019,"padj":0.98417,"ES":0.46337,"NES":0.80255,"nMoreExtreme":77802,"size":185,"leadingEdge":["LRRK2","CD38","KREMEN1","B2M","RAPGEF2","CTSZ","SEMA7A","SOX8","ASCL1","NTN1","SEMA4A","ISL2","MAP2","RGMA","LPAR1","SEMA4D","DENND5A","SLIT2","TRIM46","RUFY3","MCF2","SOX2","SEMA3F"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ION_TRANSMEMBRANE_TRANSPORT","pval":0.83051,"padj":0.97439,"ES":0.50193,"NES":0.8023,"nMoreExtreme":62363,"size":75,"leadingEdge":["CAMK2D","SRI","DYSF","KCNE5","GEM","KCNE1","TGFB1","ACTN2","MIR212","CLIC2","KCNE1B","GPR35"]} {"pathway":"GO_DNA_LIGATION_INVOLVED_IN_DNA_REPAIR","pval":0.77038,"padj":0.96082,"ES":0.62806,"NES":0.80223,"nMoreExtreme":43051,"size":9,"leadingEdge":["POLB","LIG4","LIG3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CAMP_MEDIATED_SIGNALING","pval":0.77896,"padj":0.96098,"ES":0.63181,"NES":0.8021,"nMoreExtreme":43968,"size":10,"leadingEdge":["RAPGEF2","CGAS","GIPR"]} {"pathway":"GO_CHONDROCYTE_DIFFERENTIATION","pval":0.85408,"padj":0.97645,"ES":0.48772,"NES":0.80182,"nMoreExtreme":66887,"size":98,"leadingEdge":["SCIN","COMP","CHST11","SMPD3","TGFB1","SMAD3","COCH","COL27A1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_NEURON_DEATH","pval":0.89532,"padj":0.98309,"ES":0.46672,"NES":0.80133,"nMoreExtreme":75883,"size":163,"leadingEdge":["LRRK2","HLA-F","ATP13A2","JAK2","CSF1","NR4A3","SOD2","NR4A2","CCL2","STAT3","GCLC","LIG4","CX3CL1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELL_DEVELOPMENT","pval":0.96104,"padj":0.9934,"ES":0.44391,"NES":0.80125,"nMoreExtreme":91879,"size":440,"leadingEdge":["HGF","AGT","SCARF1","P2RX4","RAPGEF2","EDN1","VEGFC","C21orf91","S100A10","BCL6","LYN","CSF1","LTA","NRCAM","IL6","SEMA7A","TNF","SOX8","CAMK1D","NCOA1","ASCL1","NTN1","CXCL12","P2RY12","PAK1","TGIF2","TGFB1","ROBO1","LIG4","LPAR1","HAS2","CCL3","CX3CL1","CFLAR","NFE2L2","LIN28A","SEMA4D","SYT17","SLIT2","NGF","RUFY3","COBL","PROX1","HAP1","LIMK1","PTN","NEUROG1"]} {"pathway":"GO_NEPHRON_EPITHELIUM_DEVELOPMENT","pval":0.84392,"padj":0.97458,"ES":0.49321,"NES":0.80099,"nMoreExtreme":64852,"size":87,"leadingEdge":["STAT1","AGT","SOX8","MYO1E","PODXL","TGFB1","FOXC1","GATA3","HOXD11","WNT1","HNF1B","SIX1"]} {"pathway":"GO_AORTA_DEVELOPMENT","pval":0.79975,"padj":0.96646,"ES":0.53311,"NES":0.8008,"nMoreExtreme":55665,"size":46,"leadingEdge":["ROBO1","NKX3-1","TBX1","PROX1","PRICKLE1","SIX1","AP2B1"]} {"pathway":"GO_PROTEIN_ACETYLATION","pval":0.90235,"padj":0.98417,"ES":0.46362,"NES":0.80053,"nMoreExtreme":77338,"size":177,"leadingEdge":["MUC1","JADE2","BAZ1A","IRF4","NCOA1","AUTS2","TGFB1","GATA3","NUPR1","GTF2B"]} {"pathway":"GO_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES","pval":0.90395,"padj":0.98417,"ES":0.46233,"NES":0.80028,"nMoreExtreme":77881,"size":183,"leadingEdge":["CEACAM1","SELL","VCAM1","ICAM1","MDGA1","KLF4","IL1RN","MPZL2","ANXA3","ITGAL","NTNG2","ROBO1","CX3CL1"]} {"pathway":"GO_REGULATION_OF_TISSUE_REMODELING","pval":0.81534,"padj":0.971,"ES":0.51959,"NES":0.79943,"nMoreExtreme":58207,"size":55,"leadingEdge":["P2RX7","CD38","IL15","CEACAM1","AGT","TNFAIP3","IL6","SRC","TGFB1"]} {"pathway":"GO_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS","pval":0.97312,"padj":0.99756,"ES":0.44025,"NES":0.79933,"nMoreExtreme":94680,"size":563,"leadingEdge":["IL15","GK","ACSL1","TYMP","MUC1","VPS9D1","SOAT1","JAK3","NPR1","TMTC1","SDC3","GCNT3","CMPK2","DSE","B4GALT5","CHST11","HS3ST3B1","SMPD3","ACSL5","ST3GAL5","ELOVL7","TMTC2","STAT3","TGFB1","ACSS1","CCL19","GALNT12","ADA2","NAGK","ST6GALNAC2","GUCY1A1","CHST2","HAS2","GUCY1B1","FUT4","HS3ST3A1","AK4","PLCB1","PDGFB","LMF1","RFK","PIGY"]} {"pathway":"GO_CENTRAL_NERVOUS_SYSTEM_NEURON_AXONOGENESIS","pval":0.78304,"padj":0.96311,"ES":0.56617,"NES":0.79921,"nMoreExtreme":51261,"size":31,"leadingEdge":["SPTBN4","B4GALT5","NR4A2","SLIT2","MYCBP2"]} {"pathway":"GO_TRANSCYTOSIS","pval":0.78147,"padj":0.96254,"ES":0.61776,"NES":0.7989,"nMoreExtreme":47223,"size":17,"leadingEdge":["PTAFR","SRC","MFSD2A","VPS35"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PLASMA_MEMBRANE_BOUNDED_CELL_PROJECTION_ASSEMBLY","pval":0.84674,"padj":0.97536,"ES":0.49309,"NES":0.79888,"nMoreExtreme":64835,"size":85,"leadingEdge":["P2RX7","AUTS2","P2RY12","CDC42EP2","CCL19","RHOQ","RIPOR2","COBL","HAP1","WNT1","HDAC4"]} {"pathway":"GO_NEURAL_RETINA_DEVELOPMENT","pval":0.79528,"padj":0.96642,"ES":0.5447,"NES":0.79827,"nMoreExtreme":54017,"size":39,"leadingEdge":["SOX8","RAB11FIP4","RORB","PTN","SMARCD3","PROM1"]} {"pathway":"GO_POST_EMBRYONIC_ANIMAL_MORPHOGENESIS","pval":0.78142,"padj":0.96254,"ES":0.62869,"NES":0.79814,"nMoreExtreme":44107,"size":10,"leadingEdge":["BCL2L11","BAK1"]} {"pathway":"GO_BILE_ACID_AND_BILE_SALT_TRANSPORT","pval":0.78803,"padj":0.96351,"ES":0.6302,"NES":0.79804,"nMoreExtreme":45455,"size":12,"leadingEdge":["CEACAM1","SLC51A","NCOA1","AQP9"]} {"pathway":"GO_SKELETAL_MUSCLE_ACETYLCHOLINE_GATED_CHANNEL_CLUSTERING","pval":0.78632,"padj":0.96311,"ES":0.63015,"NES":0.79797,"nMoreExtreme":44898,"size":11,"leadingEdge":["COLQ","PTN"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION","pval":0.79883,"padj":0.96646,"ES":0.54074,"NES":0.79789,"nMoreExtreme":54595,"size":41,"leadingEdge":["IL6","TNF","TGFB1","SORT1","GATA3","SMAD3","WNT1"]} {"pathway":"GO_REGULATION_OF_NMDA_RECEPTOR_ACTIVITY","pval":0.77817,"padj":0.96098,"ES":0.59207,"NES":0.79787,"nMoreExtreme":48960,"size":23,"leadingEdge":["RASGRF1","ANXA3","ACTN2","RGS9","MAPK8IP2","DLG3"]} {"pathway":"GO_REGULATION_OF_EMBRYONIC_DEVELOPMENT","pval":0.87097,"padj":0.97717,"ES":0.47872,"NES":0.79736,"nMoreExtreme":69747,"size":112,"leadingEdge":["AMOT","KLF4","NRK","IL1RN","B4GALT5","RNF207","TGIF2","GATA3","NFE2L2","PLCB1","GPR161","WNT1","HNF1B","LAMA1","SIX1"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_EXOGENOUS_DSRNA","pval":0.785,"padj":0.96311,"ES":0.62054,"NES":0.79718,"nMoreExtreme":47023,"size":16,"leadingEdge":["RALB","IFIH1","TLR3","DDX58","CGAS","FLOT1"]} {"pathway":"GO_REGULATION_OF_PLATELET_ACTIVATION","pval":0.77964,"padj":0.96109,"ES":0.58751,"NES":0.79681,"nMoreExtreme":49375,"size":24,"leadingEdge":["CEACAM1","PLEK","LYN","PDGFRA","PDGFB","FCER1G","TLR4"]} {"pathway":"GO_STEM_CELL_PROLIFERATION","pval":0.85413,"padj":0.97645,"ES":0.48924,"NES":0.79619,"nMoreExtreme":65800,"size":89,"leadingEdge":["LRRK2","OVOL1","ABCB1","VEGFC","ASCL1","PTPRC","TRIM71","RUNX1","TGFB1","CX3CL1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_ADAPTATION","pval":0.80675,"padj":0.96769,"ES":0.59719,"NES":0.79597,"nMoreExtreme":40367,"size":1,"leadingEdge":["PPP3CA"]} {"pathway":"GO_CELLULAR_LIPID_CATABOLIC_PROCESS","pval":0.90532,"padj":0.98417,"ES":0.46279,"NES":0.79575,"nMoreExtreme":76997,"size":166,"leadingEdge":["ENPP2","PLA2G4C","DECR1","PLA2G4A","SMPD3","LIPG","MMAA","GM2A","ACBD5","CPT1A","FABP4"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_HISTONE_H3_K9_TRIMETHYLATION","pval":0.70783,"padj":0.9508,"ES":0.59507,"NES":0.79572,"nMoreExtreme":37988,"size":6,"leadingEdge":["KDM4A","SIRT1","SMARCB1","PIH1D1","KDM4C"]} {"pathway":"GO_POSITIVE_REGULATION_OF_HISTONE_H4_ACETYLATION","pval":0.74056,"padj":0.95908,"ES":0.60785,"NES":0.79511,"nMoreExtreme":40253,"size":7,"leadingEdge":["MUC1","AUTS2","SMARCB1"]} {"pathway":"GO_EMBRYONIC_ORGAN_MORPHOGENESIS","pval":0.92285,"padj":0.987,"ES":0.45536,"NES":0.79486,"nMoreExtreme":80982,"size":209,"leadingEdge":["DNAAF1","EDN1","TIFAB","NR4A3","RNF207","FGF10","CHST11","HPN","NTN1","AUTS2","VAX2","PDGFRA","GATA3","SMAD3","PDZD7","PAX5","HLX","INSIG2","TBX1","PROX1","NEUROG1","WNT1","HNF1B"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_ACTIVITY","pval":0.78602,"padj":0.96311,"ES":0.61424,"NES":0.79435,"nMoreExtreme":47498,"size":17,"leadingEdge":["GCH1","TNF","S100A1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_HISTONE_H4_ACETYLATION","pval":0.66497,"padj":0.94905,"ES":0.57726,"NES":0.79407,"nMoreExtreme":35185,"size":5,"leadingEdge":["ATG5","SPI1","SIRT1","PIH1D1"]} {"pathway":"GO_IN_UTERO_EMBRYONIC_DEVELOPMENT","pval":0.94844,"padj":0.9911,"ES":0.44637,"NES":0.79388,"nMoreExtreme":87139,"size":298,"leadingEdge":["ASCL2","AMOT","BCL2L11","HORMAD1","EDN1","NRK","MAFF","NPM2","SOX8","HOPX","UBE2A","NCOA1","SOCS3","NBN","MYO1E","STMN3","PDGFRA","CDKN1C","LIG4","FOXC1","GATA3","PDGFB","SMAD3"]} {"pathway":"GO_SPINAL_CORD_PATTERNING","pval":0.79171,"padj":0.96486,"ES":0.62619,"NES":0.7935,"nMoreExtreme":46109,"size":13,"leadingEdge":["CHRD","ASCL1","GLI2"]} {"pathway":"GO_RESPONSE_TO_UV_B","pval":0.78844,"padj":0.96385,"ES":0.61756,"NES":0.79335,"nMoreExtreme":47229,"size":16,"leadingEdge":["IL12A","CDKN1A","HYAL2"]} {"pathway":"GO_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS","pval":0.85593,"padj":0.97645,"ES":0.48908,"NES":0.79321,"nMoreExtreme":65642,"size":86,"leadingEdge":["LRRK2","GRIN3A","DTNBP1","CACNA1I","TRIM9","SYT5","NAPA","SYT17"]} {"pathway":"GO_INDOLE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS","pval":0.81084,"padj":0.96976,"ES":0.59511,"NES":0.7932,"nMoreExtreme":40572,"size":1,"leadingEdge":["TPH2"]} {"pathway":"GO_NEPHRON_TUBULE_FORMATION","pval":0.79154,"padj":0.96486,"ES":0.62289,"NES":0.79268,"nMoreExtreme":46590,"size":14,"leadingEdge":["SOX8","GATA3","HNF1B","SIX1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY","pval":0.78661,"padj":0.96311,"ES":0.60836,"NES":0.7923,"nMoreExtreme":47858,"size":18,"leadingEdge":["LRRK2","C3","ACPP"]} {"pathway":"GO_PIGMENT_ACCUMULATION","pval":0.79268,"padj":0.96486,"ES":0.62539,"NES":0.79194,"nMoreExtreme":45723,"size":12,"leadingEdge":["RAB38","AP3D1"]} {"pathway":"GO_PARANODAL_JUNCTION_ASSEMBLY","pval":0.70891,"padj":0.95173,"ES":0.59219,"NES":0.79187,"nMoreExtreme":38046,"size":6,"leadingEdge":["ANK2","EPB41L3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NITRIC_OXIDE_MEDIATED_SIGNAL_TRANSDUCTION","pval":0.58705,"padj":0.94167,"ES":0.53721,"NES":0.79146,"nMoreExtreme":30010,"size":3,"leadingEdge":["GUCY1A1","EGFR"]} {"pathway":"GO_REGULATION_OF_NEUROTRANSMITTER_SECRETION","pval":0.85682,"padj":0.97645,"ES":0.4896,"NES":0.79128,"nMoreExtreme":65352,"size":83,"leadingEdge":["LRRK2","GRIN3A","MCTP2","DTNBP1","KMO","NAPA","ADORA2A","KCNMB4"]} {"pathway":"GO_MONOCYTE_EXTRAVASATION","pval":0.76178,"padj":0.96082,"ES":0.61286,"NES":0.79103,"nMoreExtreme":41974,"size":8,"leadingEdge":["CD47","PLCB1"]} {"pathway":"GO_PROTEIN_INSERTION_INTO_MITOCHONDRIAL_OUTER_MEMBRANE","pval":0.66593,"padj":0.94905,"ES":0.57473,"NES":0.79059,"nMoreExtreme":35236,"size":5,"leadingEdge":["HSP90AA1","TOMM22","SAMM50","PDCD5"]} {"pathway":"GO_RESPIRATORY_SYSTEM_DEVELOPMENT","pval":0.91331,"padj":0.98626,"ES":0.45979,"NES":0.79058,"nMoreExtreme":77677,"size":166,"leadingEdge":["DNAAF1","HSD11B1","CTSZ","FGF10","TNF","SMPD3","ASCL1","CHI3L1","PDGFRA","TNS3","CRISPLD2","HEG1","ASS1","ALDH1A2","PROX1","PTN","LAMA1","SIX1"]} {"pathway":"GO_EPIDERMIS_MORPHOGENESIS","pval":0.78921,"padj":0.96429,"ES":0.60248,"NES":0.79002,"nMoreExtreme":48471,"size":19,"leadingEdge":["KLF4","FGF10","FGFR2"]} {"pathway":"GO_RENAL_VESICLE_FORMATION","pval":0.7622,"padj":0.96082,"ES":0.61201,"NES":0.78993,"nMoreExtreme":41997,"size":8,"leadingEdge":["SOX8","SALL1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY","pval":0.80146,"padj":0.96646,"ES":0.55088,"NES":0.78975,"nMoreExtreme":53205,"size":34,"leadingEdge":["BCL6","CHAC1","NFKBIA","TCIM","GDPD5"]} {"pathway":"GO_MULTICELLULAR_ORGANISMAL_HOMEOSTASIS","pval":0.96114,"padj":0.9934,"ES":0.44119,"NES":0.78929,"nMoreExtreme":89776,"size":340,"leadingEdge":["P2RX7","SNX10","CD38","IL15","NOD2","JAK2","ACSL1","FLT3LG","B2M","P2RX4","PIWIL4","CSF1","NR4A3","IL7","IRF4","TNFAIP3","IL6","DECR1","GADD45G","TNF","NR1H3","STAT3","SRC","UCP2","PRDX1","PTGS2","HAS2","FOXC1","PPARGC1B"]} {"pathway":"GO_REGULATION_OF_MEGAKARYOCYTE_DIFFERENTIATION","pval":0.81657,"padj":0.971,"ES":0.527,"NES":0.78902,"nMoreExtreme":56691,"size":45,"leadingEdge":["SCIN","NR4A3","MOV10","RUNX1","GP1BA","PRKCQ"]} {"pathway":"GO_ENDOCYTIC_RECYCLING","pval":0.81598,"padj":0.971,"ES":0.5285,"NES":0.78852,"nMoreExtreme":56455,"size":44,"leadingEdge":["LMTK2","DENND1B","ACTN2","RAB11FIP4","EHD1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS","pval":0.79053,"padj":0.96481,"ES":0.60125,"NES":0.7884,"nMoreExtreme":48552,"size":19,"leadingEdge":["CYP27B1","ERLIN1","INSIG2","PROX1","SNAI2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_GONAD_DEVELOPMENT","pval":0.76325,"padj":0.96082,"ES":0.61053,"NES":0.78802,"nMoreExtreme":42055,"size":8,"leadingEdge":["SRC","SEMA3A"]} {"pathway":"GO_NEURON_DEATH","pval":0.95396,"padj":0.9932,"ES":0.44364,"NES":0.78765,"nMoreExtreme":87257,"size":287,"leadingEdge":["LRRK2","HLA-F","ATP13A2","JAK2","BCL2L11","POLB","CCL5","CSF1","NR4A3","SOD2","CTSZ","TNF","ASCL1","NR4A2","CCL2","KMO","STAT3","GCLC","NAMPT","MCL1","LIG4","CCL3","CX3CL1","GATA3","RILPL1","NGF","RAPSN","TLR4","AGAP2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TRANSLATIONAL_INITIATION","pval":0.79154,"padj":0.96486,"ES":0.57705,"NES":0.78746,"nMoreExtreme":50423,"size":25,"leadingEdge":["CCL5","TNF","DHX29"]} {"pathway":"GO_REGULATION_OF_ORGANELLE_ORGANIZATION","pval":0.99652,"padj":1,"ES":0.42999,"NES":0.7871,"nMoreExtreme":99370,"size":1120,"leadingEdge":["P2RX7","CALCOCO2","LRRK2","PLEK","HGF","TNFSF10","ATP13A2","PADI2","OPTN","STAT2","XRN1","CAMK2D","SPTBN4","ICAM1","RMI2","BCL2L11","MUC1","PRRT2","PML","PARP10","CYLD","HORMAD1","STAP1","SCIN","ATF5","USP6NL","RALB","TMSB10","EDN1","FAM107A","RHOBTB3","PMAIP1","S100A10","CHMP4C","PTGER4","BCL6","PPM1E","CDKL1","NPM2","PARP3","RND1","TNF","TEX14","CD47","SMPD3","PDE4DIP","CXCL12","ACTR3C","RHOH","ATG3","AUTS2","NBN","PAK1","TRIM9","SRC","TGFB1","ARHGAP17","CDC42EP2","STMN3","UVRAG","STMND1","PDGFRA","CDKN1C","STN1","RHOQ","ACTN2","MAP2","LIG4","PKHD1","LPAR1","GPM6B","PARL","CX3CL1","PRELID1","AP1AR","GATA3","CCNA1","BBC3","PLCB1","PDGFB","SMAD3","SPTA1","SLIT2","BAK1","IL1A","DDHD1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION","pval":0.85719,"padj":0.97645,"ES":0.49101,"NES":0.78701,"nMoreExtreme":64590,"size":77,"leadingEdge":["CD74","STAT1","SCIN","CSF1","TNF","STAT3","RUNX1","TGFB1","OCSTAMP","ISG15","PPARGC1B"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY","pval":0.82668,"padj":0.97439,"ES":0.51919,"NES":0.78666,"nMoreExtreme":58006,"size":49,"leadingEdge":["AGT","STAP1","NCF1","CCL5","SRC","PTPN1","GAS6","SRCIN1","PDGFB","LILRA5","EREG"]} {"pathway":"GO_REGULATION_OF_MACROPHAGE_CHEMOTAXIS","pval":0.79244,"padj":0.96486,"ES":0.59991,"NES":0.78665,"nMoreExtreme":48669,"size":19,"leadingEdge":["STAP1","SLAMF8","CCL5","CSF1"]} {"pathway":"GO_COGNITION","pval":0.93731,"padj":0.98783,"ES":0.44976,"NES":0.7865,"nMoreExtreme":82602,"size":215,"leadingEdge":["HLA-DRA","EGR2","AGT","RASGRF1","CBR3","FAM107A","CTNS","TIFAB","JPH4","TNF","GM2A","PTGS2","PLCB1","SLC8A2","NGF","SHISA7","ARC","MAPK8IP2","PTN","NEUROG1","BTG2"]} {"pathway":"GO_RESPONSE_TO_COLD","pval":0.81645,"padj":0.971,"ES":0.53103,"NES":0.78642,"nMoreExtreme":55986,"size":42,"leadingEdge":["CXCL10","VGF","UCP2","NFKBIA","PLAC8"]} {"pathway":"GO_REGULATION_OF_CELLULAR_EXTRAVASATION","pval":0.79229,"padj":0.96486,"ES":0.59133,"NES":0.78611,"nMoreExtreme":49309,"size":21,"leadingEdge":["ICAM1","PTGER4","CXCL12","PTAFR","RIPOR2","PLCB1"]} {"pathway":"GO_GASTRULATION","pval":0.9114,"padj":0.98539,"ES":0.46132,"NES":0.78562,"nMoreExtreme":76011,"size":146,"leadingEdge":["AMOT","CHRD","ITGA7","KLF4","IL1RN","NR4A3","TGIF2","FOXC1","SMAD3"]} {"pathway":"GO_GLOMERULAR_BASEMENT_MEMBRANE_DEVELOPMENT","pval":0.76449,"padj":0.96082,"ES":0.60822,"NES":0.78504,"nMoreExtreme":42123,"size":8,"leadingEdge":["MYO1E","MPV17"]} {"pathway":"GO_FOREBRAIN_GENERATION_OF_NEURONS","pval":0.81966,"padj":0.97144,"ES":0.52808,"NES":0.78488,"nMoreExtreme":56439,"size":43,"leadingEdge":["RAPGEF2","ATF5","ASCL1","SLC4A10","AUTS2","ROBO1","SLIT2","PROX1"]} {"pathway":"GO_PIGMENT_METABOLIC_PROCESS","pval":0.83826,"padj":0.97458,"ES":0.50992,"NES":0.78456,"nMoreExtreme":59843,"size":55,"leadingEdge":["RAPGEF2","ALAS1","CTNS","COX10"]} {"pathway":"GO_HISTONE_H4_K12_ACETYLATION","pval":0.74426,"padj":0.95959,"ES":0.59955,"NES":0.78426,"nMoreExtreme":40454,"size":7,"leadingEdge":["JADE2","JADE3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELL_CYCLE","pval":0.9858,"padj":0.99994,"ES":0.43134,"NES":0.78315,"nMoreExtreme":95913,"size":563,"leadingEdge":["IRF1","PSME2","PSMB9","FBXO6","PSME1","PSMB10","PLAAT3","OVOL1","PSMB8","KLF4","MUC1","PML","HORMAD1","ATF5","BTN2A2","MIR503","FAM107A","HLA-G","CHMP4C","BCL6","IL12A","TNFAIP3","FGF10","NOTCH2","TNF","TEX14","PSMA4","PSMA2","CUL1","MIIP","LILRB1","CCL2","NBN","TGFB1","CXCL8","CDKN1A","PSMA5","RRAGC","CDKN1C","PTGS2","GAS6","FOXC1","RRAGD","GATA3","NKX3-1","NEK11","SMAD3"]} {"pathway":"GO_RAP_PROTEIN_SIGNAL_TRANSDUCTION","pval":0.80046,"padj":0.96646,"ES":0.61471,"NES":0.78227,"nMoreExtreme":47115,"size":14,"leadingEdge":["RAPGEF2","TIMP2"]} {"pathway":"GO_EPITHELIAL_CELL_DEVELOPMENT","pval":0.92157,"padj":0.987,"ES":0.45677,"NES":0.782,"nMoreExtreme":77687,"size":156,"leadingEdge":["ONECUT2","ICAM1","SIDT2","RAPGEF2","MARVELD2","TNF","SOX8","MYO1E","PODXL","CDKN1A","RILPL1","PDGFB","PDZD7","PPP1R16B","HEG1","SLC9A4","MET","PROX1"]} {"pathway":"GO_PHOSPHATIDYLGLYCEROL_ACYL_CHAIN_REMODELING","pval":0.76579,"padj":0.96082,"ES":0.60579,"NES":0.7819,"nMoreExtreme":42195,"size":8,"leadingEdge":["PLA2G4A","LPGAT1"]} {"pathway":"GO_REGULATION_OF_SYNAPTIC_VESICLE_TRANSPORT","pval":0.85314,"padj":0.97645,"ES":0.49654,"NES":0.78189,"nMoreExtreme":62768,"size":66,"leadingEdge":["LRRK2","GRIN3A","DTNBP1","MAP2","NAPA","ADORA2A"]} {"pathway":"GO_REGULATION_OF_NEUROMUSCULAR_JUNCTION_DEVELOPMENT","pval":0.79136,"padj":0.96486,"ES":0.61574,"NES":0.7817,"nMoreExtreme":44668,"size":10,"leadingEdge":["COLQ","PTN","SIX1"]} {"pathway":"GO_METANEPHRIC_TUBULE_MORPHOGENESIS","pval":0.76598,"padj":0.96082,"ES":0.60524,"NES":0.78119,"nMoreExtreme":42205,"size":8,"leadingEdge":["SOX8","PKD1"]} {"pathway":"GO_DETECTION_OF_STIMULUS","pval":0.93306,"padj":0.98762,"ES":0.45229,"NES":0.78033,"nMoreExtreme":79818,"size":175,"leadingEdge":["C4B","NOD2","RTP4","CDS1","HPN","CXCL12","GUCA1A","PDZD7","OR2A5","TLR4","KCNMB1","KCNMB4","PKD2L1","TLR1"]} {"pathway":"GO_BEHAVIOR","pval":0.97923,"padj":0.99901,"ES":0.43289,"NES":0.78029,"nMoreExtreme":93254,"size":419,"leadingEdge":["IDO1","LRRK2","EGR2","KCNJ10","AGT","SPTBN4","RASGRF1","P2RX4","CTNS","TIFAB","NR4A3","JPH4","ADM2","SCN9A","NCOA1","CXCL12","SLC4A10","NR4A2","AUTS2","STAT3","GM2A","CREBRF","PTGS2","ASTN1","SEZ6L","CCL3","PLCB1","GLS","SLC8A2","PAX5","NGF","SHISA7","ARC","MAPK8IP2","CPT1A","NPC1"]} {"pathway":"GO_IRON_ION_TRANSPORT","pval":0.85124,"padj":0.97645,"ES":0.5009,"NES":0.77956,"nMoreExtreme":61702,"size":60,"leadingEdge":["LMTK2","STEAP4","FLVCR2","B2M","SLC25A28","ATP6V1A"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION","pval":0.98905,"padj":1,"ES":0.42886,"NES":0.77955,"nMoreExtreme":96562,"size":596,"leadingEdge":["GBP1","LRRK2","CD38","CXCL10","HGF","KREMEN1","XRN1","SPTBN4","PRRT2","B2M","MEFV","HORMAD1","RAPGEF2","STAP1","SCIN","TMSB10","FAM107A","PTGER4","CTSZ","SEMA7A","TNF","TEX14","NTN1","NR1H3","LILRB1","NBN","TRIM9","SRC","TGFB1","SEMA4A","STN1","MAP2","RGMA","LPAR1","PRELID1","AP1AR","CFLAR","SEMA4D","ANKRD13A","DENND5A","SPTA1","SLIT2","TRIM46","PAX5"]} {"pathway":"GO_PROTEIN_TARGETING_TO_VACUOLE","pval":0.81309,"padj":0.97053,"ES":0.549,"NES":0.77915,"nMoreExtreme":53470,"size":32,"leadingEdge":["SNX16","NCOA4","GCC2","M6PR"]} {"pathway":"GO_ORGAN_OR_TISSUE_SPECIFIC_IMMUNE_RESPONSE","pval":0.80286,"padj":0.96646,"ES":0.61211,"NES":0.77897,"nMoreExtreme":47256,"size":14,"leadingEdge":["GCNT3","IL6","NOS2"]} {"pathway":"GO_RNA_POLYMERASE_I_PREINITIATION_COMPLEX_ASSEMBLY","pval":0.78235,"padj":0.96269,"ES":0.60977,"NES":0.77886,"nMoreExtreme":43720,"size":9,"leadingEdge":["BAZ2A","RRN3","SMARCB1","TAF1C","PIH1D1","UBTF","TAF1B","SMARCA4","POLR1E"]} {"pathway":"GO_ACTIN_CYTOSKELETON_REORGANIZATION","pval":0.88592,"padj":0.98086,"ES":0.47656,"NES":0.77839,"nMoreExtreme":68667,"size":92,"leadingEdge":["PLEK","STAP1","NRK","DTNBP1","FGF10","FARP2","AUTS2","PAK1","TGFB1","PDGFRA","PTPN1"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_GROWTH_HORMONE_STIMULUS","pval":0.80255,"padj":0.96646,"ES":0.60186,"NES":0.77834,"nMoreExtreme":48497,"size":17,"leadingEdge":["JAK2","JAK3","LYN","STAT5A","STAT3","PTPN1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELLULAR_SENESCENCE","pval":0.80305,"padj":0.96646,"ES":0.60559,"NES":0.77797,"nMoreExtreme":48104,"size":16,"leadingEdge":["BCL6","NAMPT","SIRT1"]} {"pathway":"GO_CELL_AGING","pval":0.88994,"padj":0.98144,"ES":0.47465,"NES":0.77715,"nMoreExtreme":69264,"size":94,"leadingEdge":["ICAM1","PML","HLA-G","BCL6","CGAS","CDKN1A","NAMPT","ZNF277","WNT1","MAGEA2"]} {"pathway":"GO_REGULATION_OF_PROTEIN_ACETYLATION","pval":0.85986,"padj":0.97645,"ES":0.49449,"NES":0.777,"nMoreExtreme":63097,"size":65,"leadingEdge":["MUC1","AUTS2","TGFB1","GATA3","MAGEA2"]} {"pathway":"GO_AUTONOMIC_NERVOUS_SYSTEM_DEVELOPMENT","pval":0.81927,"padj":0.97133,"ES":0.54187,"NES":0.77683,"nMoreExtreme":54387,"size":34,"leadingEdge":["EGR2","VCAM1","SOX8","ASCL1","GATA3","HLX","EDNRA","TBX1","SEMA3F","SIX1"]} {"pathway":"GO_DSRNA_TRANSPORT","pval":0.67009,"padj":0.94905,"ES":0.56461,"NES":0.77667,"nMoreExtreme":35456,"size":5,"leadingEdge":["SIDT2","FLOT1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ORGANELLE_ASSEMBLY","pval":0.85791,"padj":0.97645,"ES":0.49711,"NES":0.77657,"nMoreExtreme":62483,"size":62,"leadingEdge":["RALB","EDN1","TNF","SRC","PROX1","HAP1","LCP1"]} {"pathway":"GO_SKELETAL_SYSTEM_DEVELOPMENT","pval":0.98217,"padj":0.99935,"ES":0.43141,"NES":0.77654,"nMoreExtreme":93174,"size":402,"leadingEdge":["P2RX7","HAPLN3","CHRD","COL9A2","SCIN","EDN1","COMP","PTGER4","TIFAB","AMER1","NOTCH2","CHST11","SMPD3","PTPRC","CHI3L1","AUTS2","LILRB1","SRC","TGFB1","SNORC","PRDX1","PDGFRA","CDKN1C","HAS2","HOXD8","FOXC1","PPARGC1B","SEMA4D","SMAD3","PAX5","ARID5B","INSIG2","KIAA1217","TBX1","COCH","NEUROG1","WNT1","COL27A1","HDAC4"]} {"pathway":"GO_SENSORY_PERCEPTION_OF_MECHANICAL_STIMULUS","pval":0.90207,"padj":0.98417,"ES":0.46753,"NES":0.77619,"nMoreExtreme":71851,"size":108,"leadingEdge":["SPTBN4","ICAM1","P2RX4","MARVELD2","CLIC5","HPN","CXCL12","KCNE1","RIPOR2","TECTA","PDZD7","TBX1","COCH"]} {"pathway":"GO_PROGESTERONE_BIOSYNTHETIC_PROCESS","pval":0.62335,"padj":0.94878,"ES":0.54494,"NES":0.77601,"nMoreExtreme":32442,"size":4,"leadingEdge":["EGR1","STARD3","DGKQ","ADM"]} {"pathway":"GO_SCHWANN_CELL_DIFFERENTIATION","pval":0.81494,"padj":0.971,"ES":0.5497,"NES":0.77596,"nMoreExtreme":53349,"size":31,"leadingEdge":["EGR2","GPC1"]} {"pathway":"GO_MESODERM_MORPHOGENESIS","pval":0.85382,"padj":0.97645,"ES":0.50193,"NES":0.77577,"nMoreExtreme":61257,"size":57,"leadingEdge":["CHRD","KLF4","NR4A3","FOXC1","SMAD3"]} {"pathway":"GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY","pval":0.805,"padj":0.96696,"ES":0.5755,"NES":0.77554,"nMoreExtreme":50648,"size":23,"leadingEdge":["SOD2","MCL1","NFE2L2","SIRT1"]} {"pathway":"GO_SUBSTANTIA_NIGRA_DEVELOPMENT","pval":0.82836,"padj":0.97439,"ES":0.52881,"NES":0.77497,"nMoreExtreme":56264,"size":39,"leadingEdge":["PADI2","SYNGR3","CASP5","CKB","S100A1"]} {"pathway":"GO_REGULATION_OF_LUTEINIZING_HORMONE_SECRETION","pval":0.83802,"padj":0.97458,"ES":0.5813,"NES":0.77479,"nMoreExtreme":41932,"size":1,"leadingEdge":["SMAD4"]} {"pathway":"GO_FORMATION_OF_ANATOMICAL_BOUNDARY","pval":0.83802,"padj":0.97458,"ES":0.5813,"NES":0.77479,"nMoreExtreme":41932,"size":1,"leadingEdge":["SMAD4"]} {"pathway":"GO_REGULATION_OF_NUCLEASE_ACTIVITY","pval":0.80516,"padj":0.96696,"ES":0.58685,"NES":0.77477,"nMoreExtreme":49770,"size":20,"leadingEdge":["OAS2","OAS3","OASL"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS","pval":0.84135,"padj":0.97458,"ES":0.514,"NES":0.77447,"nMoreExtreme":58723,"size":47,"leadingEdge":["BCL2L11","CTSZ","TNF","ASCL1","MCL1","CCL3","RAPSN","HDAC4"]} {"pathway":"GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_MEMBRANE_REPOLARIZATION","pval":0.80565,"padj":0.96708,"ES":0.58246,"NES":0.77431,"nMoreExtreme":50140,"size":21,"leadingEdge":["ANK2","KCNE5","RNF207","KCNE1","KCNE1B"]} {"pathway":"GO_REGULATION_OF_SERINE_TYPE_PEPTIDASE_ACTIVITY","pval":0.67081,"padj":0.94905,"ES":0.5625,"NES":0.77376,"nMoreExtreme":35494,"size":5,"leadingEdge":["SPINK1","SPINK6"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SERINE_TYPE_PEPTIDASE_ACTIVITY","pval":0.67081,"padj":0.94905,"ES":0.5625,"NES":0.77376,"nMoreExtreme":35494,"size":5,"leadingEdge":["SPINK1","SPINK6"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INTERLEUKIN_2_BIOSYNTHETIC_PROCESS","pval":0.80582,"padj":0.96708,"ES":0.61081,"NES":0.77348,"nMoreExtreme":46481,"size":12,"leadingEdge":["CD80","IRF4","CD86","PTPRC","IL1A","PRKCQ"]} {"pathway":"GO_CRANIAL_NERVE_MORPHOGENESIS","pval":0.8066,"padj":0.96769,"ES":0.58574,"NES":0.7733,"nMoreExtreme":49859,"size":20,"leadingEdge":["EGR2","TIFAB","TBX1","NEUROG1","SEMA3F","SIX1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELL_MATRIX_ADHESION","pval":0.83742,"padj":0.97458,"ES":0.52011,"NES":0.77304,"nMoreExtreme":57662,"size":43,"leadingEdge":["S100A10","CSF1","CX3CL1","SMAD3"]} {"pathway":"GO_RESPONSE_TO_IRON_II_ION","pval":0.67111,"padj":0.94905,"ES":0.56165,"NES":0.7726,"nMoreExtreme":35510,"size":5,"leadingEdge":["MAP1LC3A","ACO1","BECN1","IREB2","SNCA"]} {"pathway":"GO_GLYCOLIPID_BIOSYNTHETIC_PROCESS","pval":0.85544,"padj":0.97645,"ES":0.50215,"NES":0.77259,"nMoreExtreme":61070,"size":55,"leadingEdge":["B4GALT5","ST3GAL5","PIGY","DPM1"]} {"pathway":"GO_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT","pval":0.99632,"padj":1,"ES":0.42328,"NES":0.77226,"nMoreExtreme":98381,"size":745,"leadingEdge":["ASCL2","LRRK2","CD38","HGF","KREMEN1","AGT","BHLHE41","TYMP","MDGA1","KLF4","SCARF1","B2M","P2RX4","RAPGEF2","STAP1","VEGFC","C21orf91","COLQ","DYNLT1","BCL6","LYN","CSF1","LTA","NRCAM","CTSZ","IL6","SEMA7A","TNF","SOX8","DUSP10","CAMK1D","MOV10","NCOA1","ASCL1","NTN1","CXCL12","STAT3","P2RY12","PAK1","TGIF2","TGFB1","SEMA4A","NTNG2","ROBO1","ISL2","MAP2","RGMA","ADGRB1","LIG4","LPAR1","CCL3","CX3CL1","CFLAR","GATA3","NFE2L2","SRCIN1","LIN28A","SEMA4D"]} {"pathway":"GO_CLATHRIN_COAT_ASSEMBLY","pval":0.80887,"padj":0.96899,"ES":0.601,"NES":0.77209,"nMoreExtreme":48453,"size":16,"leadingEdge":["FCHO1","AP2B1"]} {"pathway":"GO_CELL_PROJECTION_ASSEMBLY","pval":0.99056,"padj":1,"ES":0.42653,"NES":0.77186,"nMoreExtreme":95405,"size":485,"leadingEdge":["P2RX7","SNX10","ONECUT2","ICAM1","DNAAF1","LRRC61","CYLD","RAPGEF2","STAP1","FAM92A","CDKL1","FGD2","NTN1","ATG3","AUTS2","TUBA4A","P2RY12","PODXL","SRC","CDC42EP2","CCL19","RHOQ","ACTN2","PKHD1","LPAR1","RIPOR2","NME8","CFAP74","RILPL1","FGD6","GAS8","SLIT2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELL_GROWTH","pval":0.92362,"padj":0.987,"ES":0.45737,"NES":0.77182,"nMoreExtreme":75683,"size":130,"leadingEdge":["CD38","EDN1","CXCL16","SEMA7A","HPN","NTN1","CXCL12","PAK1","SEMA4D","SYT17","NGF","RUFY3","LIMK1"]} {"pathway":"GO_OSTEOBLAST_DIFFERENTIATION","pval":0.94466,"padj":0.98973,"ES":0.44737,"NES":0.7716,"nMoreExtreme":80757,"size":174,"leadingEdge":["HGF","CHRD","IFITM1","IL6","SEMA7A","TNF","SOX8","CCL3","SEMA4D","DNAJC13","SMAD3","RORB"]} {"pathway":"GO_PRESYNAPSE_ORGANIZATION","pval":0.82547,"padj":0.97439,"ES":0.54048,"NES":0.77116,"nMoreExtreme":54566,"size":33,"leadingEdge":["MDGA1","NTNG2","CLSTN3"]} {"pathway":"GO_REGULATION_OF_NEUROTRANSMITTER_RECEPTOR_ACTIVITY","pval":0.84852,"padj":0.97602,"ES":0.51022,"NES":0.77098,"nMoreExtreme":59408,"size":48,"leadingEdge":["RASGRF1","ANXA3","SRC","ACTN2","RGS9","SHISA7","ARC","MAPK8IP2","NPTX1","DLG3"]} {"pathway":"GO_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION","pval":0.96948,"padj":0.99625,"ES":0.43621,"NES":0.77077,"nMoreExtreme":87666,"size":261,"leadingEdge":["GBP1","LRRK2","RAPGEF2","S100A10","NRCAM","SEMA7A","NTN1","CXCL12","PAK1","SEMA4A","ROBO1","MAP2","HAS2","AP1AR","SRCIN1","SEMA4D","SLIT2","TRIM46","NGF","ARC","RUFY3","MCF2","LIMK1","LZTS1","SEMA3F","MAP6","SEMA3E"]} {"pathway":"GO_REGULATION_OF_HISTONE_H4_ACETYLATION","pval":0.81015,"padj":0.96941,"ES":0.60783,"NES":0.77023,"nMoreExtreme":47183,"size":13,"leadingEdge":["MUC1","AUTS2","ATG5"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_COLD_INDUCED_THERMOGENESIS","pval":0.84179,"padj":0.97458,"ES":0.51783,"NES":0.76965,"nMoreExtreme":57963,"size":43,"leadingEdge":["IL15","NR1H3","TLR4"]} {"pathway":"GO_REGULATION_OF_ISOMERASE_ACTIVITY","pval":0.78704,"padj":0.96311,"ES":0.6023,"NES":0.76933,"nMoreExtreme":43982,"size":9,"leadingEdge":["NOD2","PLSCR1"]} {"pathway":"GO_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_ACTIVATION","pval":0.74923,"padj":0.9603,"ES":0.58801,"NES":0.76916,"nMoreExtreme":40724,"size":7,"leadingEdge":["LTBP1","HSP90AB1","ITGB8","ITGB6","LRRC32","ITGAV","FURIN"]} {"pathway":"GO_REGULATION_OF_LIPID_CATABOLIC_PROCESS","pval":0.83626,"padj":0.97458,"ES":0.52482,"NES":0.76913,"nMoreExtreme":56800,"size":39,"leadingEdge":["HCAR2","TNF","CPT1A"]} {"pathway":"GO_PHAGOSOME_ACIDIFICATION","pval":0.81329,"padj":0.97053,"ES":0.56709,"NES":0.76912,"nMoreExtreme":51506,"size":24,"leadingEdge":["RAB20","SLAMF8","ATP6V1A","RAB38","RAB39A"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION","pval":0.9297,"padj":0.98762,"ES":0.45509,"NES":0.76887,"nMoreExtreme":76342,"size":132,"leadingEdge":["S100A10","SEMA7A","NTN1","CXCL12","PAK1","ROBO1","HAS2","SEMA4D","SLIT2","NGF","RUFY3","LIMK1","MAP6"]} {"pathway":"GO_RESPONSE_TO_BRONCHODILATOR","pval":0.83674,"padj":0.97458,"ES":0.52462,"NES":0.76884,"nMoreExtreme":56833,"size":39,"leadingEdge":["ICAM1","NR4A2","CCL19","GUCY1B1","CFLAR","RGS9","ADORA2A"]} {"pathway":"GO_REGULATION_OF_PROSTAGLANDIN_SECRETION","pval":0.78722,"padj":0.96316,"ES":0.60184,"NES":0.76873,"nMoreExtreme":43992,"size":9,"leadingEdge":["P2RX7","P2RX4","EDN1"]} {"pathway":"GO_REGULATION_OF_DENDRITE_DEVELOPMENT","pval":0.92412,"padj":0.987,"ES":0.45707,"NES":0.76871,"nMoreExtreme":75286,"size":125,"leadingEdge":["LRRK2","RAPGEF2","C21orf91","CAMK1D","LPAR1","SRCIN1","SEMA4D","ARC","COBL","LZTS1"]} {"pathway":"GO_REGULATION_OF_ODONTOGENESIS_OF_DENTIN_CONTAINING_TOOTH","pval":0.74939,"padj":0.9603,"ES":0.58755,"NES":0.76856,"nMoreExtreme":40733,"size":7,"leadingEdge":["CSF1","RSPO2"]} {"pathway":"GO_ATRIAL_CARDIAC_MUSCLE_CELL_MEMBRANE_REPOLARIZATION","pval":0.77156,"padj":0.96084,"ES":0.59523,"NES":0.76827,"nMoreExtreme":42513,"size":8,"leadingEdge":["KCNE5","KCNQ1"]} {"pathway":"GO_SKELETAL_MUSCLE_SATELLITE_CELL_ACTIVATION","pval":0.60446,"padj":0.94684,"ES":0.52115,"NES":0.7678,"nMoreExtreme":30900,"size":3,"leadingEdge":["CAPN3","MEGF10","EPHB1"]} {"pathway":"GO_OPTIC_NERVE_MORPHOGENESIS","pval":0.60446,"padj":0.94684,"ES":0.52115,"NES":0.7678,"nMoreExtreme":30900,"size":3,"leadingEdge":["GLI3","EPHB2","EPHB1"]} {"pathway":"GO_ESTABLISHMENT_OR_MAINTENANCE_OF_CELL_POLARITY","pval":0.9549,"padj":0.9934,"ES":0.44273,"NES":0.76779,"nMoreExtreme":82599,"size":188,"leadingEdge":["AMOT","RHOBTB3","DYNLT1","RND1","FGF10","RHOH","CCL4","PAK1","CCL19","RHOQ","MAP2","RIPOR2","GATA3","ARHGEF11","RUFY3"]} {"pathway":"GO_NATURAL_KILLER_CELL_MEDIATED_IMMUNE_RESPONSE_TO_TUMOR_CELL","pval":0.77176,"padj":0.96084,"ES":0.5948,"NES":0.76772,"nMoreExtreme":42524,"size":8,"leadingEdge":["CEACAM1","IL12A","CD226"]} {"pathway":"GO_REGULATION_OF_PEPTIDE_HORMONE_SECRETION","pval":0.93531,"padj":0.98762,"ES":0.45234,"NES":0.7677,"nMoreExtreme":77509,"size":140,"leadingEdge":["CD38","JAK2","SIDT2","SRI","CCL5","GLUL","TNF","UCP2","NADK","ILDR1","CPT1A","PIM3"]} {"pathway":"GO_EYE_PHOTORECEPTOR_CELL_DIFFERENTIATION","pval":0.82012,"padj":0.97171,"ES":0.5553,"NES":0.76704,"nMoreExtreme":52733,"size":27,"leadingEdge":["SOX8","STAT3","RORB","PTN","PROM1"]} {"pathway":"GO_CARBOHYDRATE_TRANSMEMBRANE_TRANSPORT","pval":0.89529,"padj":0.98309,"ES":0.47457,"NES":0.76699,"nMoreExtreme":68286,"size":83,"leadingEdge":["TMEM144","C3","SLC2A6","EDN1","NR4A3","RSC1A1","TNF","RHOQ","SORT1","NFE2L2","EDNRA"]} {"pathway":"GO_TRNA_AMINOACYLATION_FOR_MITOCHONDRIAL_PROTEIN_TRANSLATION","pval":0.71649,"padj":0.95386,"ES":0.57337,"NES":0.7667,"nMoreExtreme":38453,"size":6,"leadingEdge":["EARS2","WARS2","DARS2","AARS2","YARS2","TARS2"]} {"pathway":"GO_CELL_CYCLE_ARREST","pval":0.96535,"padj":0.99537,"ES":0.43764,"NES":0.76656,"nMoreExtreme":85390,"size":221,"leadingEdge":["IRF1","MUC1","PML","IL12A","FGF10","NOTCH2","CUL1","NBN","TGFB1","CXCL8","CDKN1A","RRAGC","CDKN1C","GAS6","RRAGD","NKX3-1","SMAD3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_PROLIFERATION","pval":0.81413,"padj":0.971,"ES":0.59659,"NES":0.76642,"nMoreExtreme":48768,"size":16,"leadingEdge":["HLA-E","RIPK2","EBI3","PTPRC"]} {"pathway":"GO_RESPONSE_TO_XENOBIOTIC_STIMULUS","pval":0.95654,"padj":0.9934,"ES":0.44248,"NES":0.76638,"nMoreExtreme":82516,"size":185,"leadingEdge":["ACSL1","CYP1A1","ICAM1","APOBEC3A","CBR3","EDN1","EPHX1","SLC8A1","PTAFR","NR4A2","GCLC","TGFB1","CES1","CFLAR","RGS9","PDGFB"]} {"pathway":"GO_NUCLEOSOME_POSITIONING","pval":0.62793,"padj":0.94878,"ES":0.53783,"NES":0.7659,"nMoreExtreme":32680,"size":4,"leadingEdge":["PAF1","RSF1","CTCF"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE","pval":0.8432,"padj":0.97458,"ES":0.52065,"NES":0.76569,"nMoreExtreme":57476,"size":40,"leadingEdge":["CYLD","DUSP10","PAFAH1B1"]} {"pathway":"GO_HEAD_DEVELOPMENT","pval":0.99667,"padj":1,"ES":0.42108,"NES":0.76564,"nMoreExtreme":97408,"size":602,"leadingEdge":["LRRK2","CHRD","EGR2","SSTR2","PADI2","LIMK2","BCL2A1","HESX1","MDGA1","BCL2L11","RAPGEF2","ATF5","C21orf91","CTNS","TRABD2A","SYNGR3","NR4A3","ANXA3","FGF10","TBX19","SEMA7A","SLC8A1","NCOA1","ASCL1","UNC5C","CXCL12","SLC4A10","NR4A2","AUTS2","CASP5","P2RY12","PAK1","SRC","TGFB1","VAX2","ROBO1","CRISPLD1","PDGFRA","LPAR1","SEZ6L","MFSD2A","FOXC1","CKB","AK4","PLCB1","NAPA","CRISPLD2","GAS8","SLIT2","BAK1","PAX5","EDNRA","S100A1","ARID5B"]} {"pathway":"GO_PROTEIN_HETEROTETRAMERIZATION","pval":0.81747,"padj":0.97133,"ES":0.56439,"NES":0.76546,"nMoreExtreme":51771,"size":24,"leadingEdge":["CD74","S100A10","PKD1"]} {"pathway":"GO_PHASIC_SMOOTH_MUSCLE_CONTRACTION","pval":0.8069,"padj":0.96769,"ES":0.60426,"NES":0.76518,"nMoreExtreme":46073,"size":11,"leadingEdge":["SSTR2","EDN1","TIFAB","NEUROG1"]} {"pathway":"GO_CANONICAL_WNT_SIGNALING_PATHWAY_INVOLVED_IN_REGULATION_OF_CELL_PROLIFERATION","pval":0.67355,"padj":0.94976,"ES":0.55625,"NES":0.76517,"nMoreExtreme":35639,"size":5,"leadingEdge":["DVL2","LRP6","SFRP1","WNT3"]} {"pathway":"GO_EMBRYO_IMPLANTATION","pval":0.84248,"padj":0.97458,"ES":0.52201,"NES":0.765,"nMoreExtreme":57223,"size":39,"leadingEdge":["ACOD1","PTGS2","FKBP4"]} {"pathway":"GO_OSTEOCLAST_DEVELOPMENT","pval":0.81589,"padj":0.971,"ES":0.59518,"NES":0.76461,"nMoreExtreme":48873,"size":16,"leadingEdge":["NOTCH2","LILRB1","SRC","PAFAH1B1"]} {"pathway":"GO_RESPONSE_TO_CARBOHYDRATE","pval":0.95643,"padj":0.9934,"ES":0.44224,"NES":0.76398,"nMoreExtreme":82067,"size":178,"leadingEdge":["ICAM1","SIDT2","SRI","GJD3","LYN","GLUL","SLC8A1","MAFA","GCLC","TGFB1","UCP2","TXNIP","NAMPT","PTGS2","GAS6","LIN28A","NADK"]} {"pathway":"GO_CANONICAL_WNT_SIGNALING_PATHWAY_INVOLVED_IN_OSTEOBLAST_DIFFERENTIATION","pval":0.665,"padj":0.94905,"ES":0.51202,"NES":0.76371,"nMoreExtreme":33417,"size":2,"leadingEdge":["WNT3","FZD1"]} {"pathway":"GO_CILIUM_ORGANIZATION","pval":0.98649,"padj":0.99994,"ES":0.42781,"NES":0.76276,"nMoreExtreme":91263,"size":313,"leadingEdge":["SNX10","ONECUT2","DNAAF1","LRRC61","CYLD","FAM92A","CDKL1","ATG3","TUBA4A","PKHD1","NME8","CFAP74","RILPL1","GAS8"]} {"pathway":"GO_REGULATION_OF_GRANULOCYTE_DIFFERENTIATION","pval":0.81656,"padj":0.971,"ES":0.60111,"NES":0.76172,"nMoreExtreme":47556,"size":13,"leadingEdge":["CEACAM1","RUNX1","C1QC"]} {"pathway":"GO_PULMONARY_VALVE_DEVELOPMENT","pval":0.81881,"padj":0.97133,"ES":0.59252,"NES":0.76119,"nMoreExtreme":49048,"size":16,"leadingEdge":["NOTCH2","ROBO1","SLIT2","TNFRSF1B"]} {"pathway":"GO_REGULATION_OF_GROWTH_HORMONE_RECEPTOR_SIGNALING_PATHWAY","pval":0.67496,"padj":0.94976,"ES":0.55331,"NES":0.76113,"nMoreExtreme":35714,"size":5,"leadingEdge":["JAK2","GDF15"]} {"pathway":"GO_REGULATION_OF_MYELOID_DENDRITIC_CELL_ACTIVATION","pval":0.71794,"padj":0.95427,"ES":0.56912,"NES":0.76101,"nMoreExtreme":38531,"size":6,"leadingEdge":["FLT3LG","TSPAN32","CLEC4D"]} {"pathway":"GO_POSITIVE_REGULATION_OF_HISTONE_H3_K27_METHYLATION","pval":0.67508,"padj":0.94976,"ES":0.55306,"NES":0.76078,"nMoreExtreme":35720,"size":5,"leadingEdge":["EED","PHF1","PHF19","MTF2","OGT"]} {"pathway":"GO_ACUTE_PHASE_RESPONSE","pval":0.83461,"padj":0.97443,"ES":0.53887,"NES":0.76068,"nMoreExtreme":54637,"size":31,"leadingEdge":["APOL2","PLSCR1","IL6","TNF","STAT3","PTGS2","IL1A","SAA2","ASS1","ORM1"]} {"pathway":"GO_EPITHELIAL_CELL_DIFFERENTIATION","pval":0.99645,"padj":1,"ES":0.42133,"NES":0.7604,"nMoreExtreme":95230,"size":438,"leadingEdge":["IL31RA","CEACAM1","STAT1","ONECUT2","OVOL1","CYP1A1","ICAM1","SIDT2","KLF4","RAPGEF2","MARVELD2","DHRS9","GSTK1","MAFF","CTSL","PRKX","FGF10","TNF","SOX8","CBR1","ASCL1","CYP27B1","MYO1E","PODXL","RUNX1","TGFB1","CDKN1A","TXNIP","CDKN1C","CES1","FOXC1","GATA3","TDRD7","RILPL1","PDGFB","SMAD3","PDZD7","ZFP36","PPP1R16B","HEG1","CPT1A","SLC9A4","EREG","TBX1","MET","PROX1"]} {"pathway":"GO_MICROGLIAL_CELL_MIGRATION","pval":0.75219,"padj":0.9603,"ES":0.58077,"NES":0.75969,"nMoreExtreme":40885,"size":7,"leadingEdge":["P2RX4","STAP1","CSF1","P2RY12","CCL3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MITOCHONDRION_ORGANIZATION","pval":0.92721,"padj":0.987,"ES":0.45754,"NES":0.75903,"nMoreExtreme":73765,"size":107,"leadingEdge":["TNFSF10","OPTN","BCL2L11","PMAIP1","BBC3","BAK1","DDHD1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ORGAN_GROWTH","pval":0.85681,"padj":0.97645,"ES":0.51245,"NES":0.7589,"nMoreExtreme":58754,"size":42,"leadingEdge":["PIM1","EDN1","IL7","HLX","PROX1"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_CAMP","pval":0.85681,"padj":0.97645,"ES":0.51245,"NES":0.7589,"nMoreExtreme":58754,"size":42,"leadingEdge":["RAPGEF2","SLC8A1","PTAFR","KCNE1","ASS1","AQP9","KDM1A"]} {"pathway":"GO_SENSORY_PERCEPTION_OF_LIGHT_STIMULUS","pval":0.92946,"padj":0.98762,"ES":0.45661,"NES":0.75807,"nMoreExtreme":74032,"size":108,"leadingEdge":["KCNJ10","GRM8","ATXN7","GUCA1A","VAX2","GABRR2","RGS9","RORB"]} {"pathway":"GO_GLIOGENESIS","pval":0.98023,"padj":0.99901,"ES":0.43099,"NES":0.75772,"nMoreExtreme":87531,"size":237,"leadingEdge":["ASCL2","EGR2","KCNJ10","P2RX4","STAP1","LYN","CSF1","LTA","B4GALT5","IL6","FGF10","TNF","SOX8","DUSP10","ASCL1","FPR2","CCL2","STAT3","P2RY12","TGFB1","LPAR1","CCL3","CX3CL1","IL33","LIN28A"]} {"pathway":"GO_NEUROBLAST_PROLIFERATION","pval":0.86213,"padj":0.97653,"ES":0.50603,"NES":0.75762,"nMoreExtreme":59854,"size":45,"leadingEdge":["LRRK2","VEGFC","ASCL1","TGFB1","CX3CL1"]} {"pathway":"GO_RESPONSE_TO_CORTICOSTERONE","pval":0.81149,"padj":0.97022,"ES":0.59826,"NES":0.75759,"nMoreExtreme":46335,"size":11,"leadingEdge":["CDKN1A","ATP2B1"]} {"pathway":"GO_TRANSFERRIN_TRANSPORT","pval":0.83929,"padj":0.97458,"ES":0.5364,"NES":0.75719,"nMoreExtreme":54943,"size":31,"leadingEdge":["LMTK2","ATP6V1A","HFE"]} {"pathway":"GO_ENDONUCLEOLYTIC_CLEAVAGE_IN_5_ETS_OF_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA_","pval":0.67604,"padj":0.94976,"ES":0.55031,"NES":0.75699,"nMoreExtreme":35771,"size":5,"leadingEdge":["NOP14","RCL1","UTP20","ABT1","UTP23"]} {"pathway":"GO_CAMERA_TYPE_EYE_DEVELOPMENT","pval":0.97935,"padj":0.99901,"ES":0.43148,"NES":0.75663,"nMoreExtreme":86863,"size":226,"leadingEdge":["LIMK2","CYP1A1","KLF4","CTNS","FGF10","SOX8","SLC25A25","TGIF2","TGFB1","VAX2","PDGFRA","CDKN1C","GPD2","FOXC1","GATA3","TDRD7","SMAD3","BAK1","RAB11FIP4","RORB","COL8A2","ALDH1A2","PROX1","PTN"]} {"pathway":"GO_BLEB_ASSEMBLY","pval":0.81289,"padj":0.97053,"ES":0.59664,"NES":0.75553,"nMoreExtreme":46415,"size":11,"leadingEdge":["P2RX7","LPAR1"]} {"pathway":"GO_LEUCINE_CATABOLIC_PROCESS","pval":0.67649,"padj":0.94976,"ES":0.54924,"NES":0.75552,"nMoreExtreme":35795,"size":5,"leadingEdge":["MCCC1","HMGCL","IVD","MCCC2","AUH"]} {"pathway":"GO_REGULATION_OF_FIBROBLAST_MIGRATION","pval":0.8395,"padj":0.97458,"ES":0.53768,"NES":0.75518,"nMoreExtreme":54726,"size":30,"leadingEdge":["SLC8A1","PAK1","TGFB1","PRR5L"]} {"pathway":"GO_REGULATION_OF_RAS_PROTEIN_SIGNAL_TRANSDUCTION","pval":0.97931,"padj":0.99901,"ES":0.43196,"NES":0.75445,"nMoreExtreme":86052,"size":211,"leadingEdge":["JAK2","RASGRF1","BCL6","LYN","CSF1","ARHGEF3","FGF10","NOTCH2","GPR18","RASGRP1","F2RL2","FARP2","FGD2","AUTS2","SH2B2","IQSEC3","ROBO1","STMN3","LPAR1","RIPOR2","FGD6","CDC42SE2","NGF","ARHGEF11","FLOT1","HEG1","GPR35","MET","MCF2"]} {"pathway":"GO_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION","pval":0.95951,"padj":0.9934,"ES":0.44184,"NES":0.75443,"nMoreExtreme":80419,"size":151,"leadingEdge":["PSME2","PSME1","CYP1A1","KLF4","MUC1","PML","BTN2A2","MIR503","FAM107A","FGF10","CCL2","CDKN1A","TCIM","PLCB1"]} {"pathway":"GO_REGULATION_OF_VESICLE_TARGETING_TO_FROM_OR_WITHIN_GOLGI","pval":0.63313,"padj":0.94878,"ES":0.52943,"NES":0.75394,"nMoreExtreme":32951,"size":4,"leadingEdge":["SAR1A","GOSR1","PREB","SAR1B"]} {"pathway":"GO_INSULIN_RECEPTOR_SIGNALING_PATHWAY","pval":0.94213,"padj":0.98878,"ES":0.45126,"NES":0.75393,"nMoreExtreme":75829,"size":116,"leadingEdge":["SOCS1","AGT","CISH","TRIM72","SOCS3","SH2B2","PTPN2","PAK1","SRC","ATP6V1A","PTPN1","RHOQ"]} {"pathway":"GO_FIBROBLAST_MIGRATION","pval":0.85513,"padj":0.97645,"ES":0.51672,"NES":0.75392,"nMoreExtreme":57821,"size":38,"leadingEdge":["PML","SLC8A1","PAK1","TGFB1","PRR5L","ARID5B"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_DNA_BINDING","pval":0.87174,"padj":0.97717,"ES":0.50016,"NES":0.75361,"nMoreExtreme":60844,"size":47,"leadingEdge":["JAK2","SRI","NFKBIA","KDM1A"]} {"pathway":"GO_CELL_FATE_DETERMINATION","pval":0.83387,"padj":0.97443,"ES":0.55216,"NES":0.7535,"nMoreExtreme":53120,"size":25,"leadingEdge":["KLF4","NOTCH2","ASCL1","MCL1","GATA3","PROX1","WNT1","CYP26B1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS","pval":0.84166,"padj":0.97458,"ES":0.53643,"NES":0.75341,"nMoreExtreme":54867,"size":30,"leadingEdge":["SOCS1","CISH","TRIM72","SOCS3","PTPN2","PTPN1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MICROTUBULE_BINDING","pval":0.72037,"padj":0.95459,"ES":0.563,"NES":0.75282,"nMoreExtreme":38661,"size":6,"leadingEdge":["MAPRE3","ABL1","MAPRE1","PPP2CB","PPP2CA"]} {"pathway":"GO_POSITIVE_REGULATION_OF_APOPTOTIC_PROCESS_INVOLVED_IN_MORPHOGENESIS","pval":0.67727,"padj":0.94976,"ES":0.54722,"NES":0.75274,"nMoreExtreme":35836,"size":5,"leadingEdge":["TNFRSF1B","TNFRSF1A","BAX","VDR","NOTCH1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_APOPTOTIC_PROCESS_INVOLVED_IN_DEVELOPMENT","pval":0.67727,"padj":0.94976,"ES":0.54722,"NES":0.75274,"nMoreExtreme":35836,"size":5,"leadingEdge":["TNFRSF1B","TNFRSF1A","BAX","VDR","NOTCH1"]} {"pathway":"GO_INTERMEDIATE_FILAMENT_BUNDLE_ASSEMBLY","pval":0.63371,"padj":0.94878,"ES":0.52845,"NES":0.75254,"nMoreExtreme":32981,"size":4,"leadingEdge":["PKP2","NEFH","NEFM"]} {"pathway":"GO_REGULATION_OF_ANGIOTENSIN_LEVELS_IN_BLOOD","pval":0.77819,"padj":0.96098,"ES":0.58284,"NES":0.75228,"nMoreExtreme":42878,"size":8,"leadingEdge":["CTSZ","CES1","ENPEP"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TYPE_B_PANCREATIC_CELL_APOPTOTIC_PROCESS","pval":0.63405,"padj":0.94878,"ES":0.52809,"NES":0.75202,"nMoreExtreme":32999,"size":4,"leadingEdge":["WFS1","SRSF6","TCF7L2","CAST"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS","pval":0.87742,"padj":0.97965,"ES":0.49616,"NES":0.75176,"nMoreExtreme":61567,"size":49,"leadingEdge":["PMAIP1","DGAT2","PTAFR","PTPN2","SRC","HAS2","PDGFB","ESRRB","CD244"]} {"pathway":"GO_PYRUVATE_METABOLIC_PROCESS","pval":0.83041,"padj":0.97439,"ES":0.56933,"NES":0.75163,"nMoreExtreme":51331,"size":20,"leadingEdge":["NR4A3","LDHAL6B","HAGH"]} {"pathway":"GO_POSITIVE_REGULATION_OF_GLUCOKINASE_ACTIVITY","pval":0.63438,"padj":0.94878,"ES":0.52764,"NES":0.75138,"nMoreExtreme":33016,"size":4,"leadingEdge":["BAD","DUSP12","PFKFB2","RANBP2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS","pval":0.89614,"padj":0.98354,"ES":0.48004,"NES":0.75136,"nMoreExtreme":65452,"size":63,"leadingEdge":["ONECUT2","HTRA4","CHST11","TGFB1","CFLAR","SMAD3","WNT1","EID2"]} {"pathway":"GO_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR","pval":0.90993,"padj":0.98498,"ES":0.47058,"NES":0.75124,"nMoreExtreme":68214,"size":74,"leadingEdge":["RMI2","PML","DTX3L","PARP3","PARP9","CGAS","HELB"]} {"pathway":"GO_PULMONARY_VALVE_MORPHOGENESIS","pval":0.82468,"padj":0.97439,"ES":0.59254,"NES":0.75085,"nMoreExtreme":48029,"size":13,"leadingEdge":["NOTCH2","ROBO1","SLIT2"]} {"pathway":"GO_CELL_JUNCTION_ASSEMBLY","pval":0.98228,"padj":0.99935,"ES":0.43025,"NES":0.75067,"nMoreExtreme":86088,"size":207,"leadingEdge":["AGT","RAPGEF2","GJD3","MARVELD2","FAM107A","ANK2","S100A10","TNF","RUNX1","SRC","ACTN2","GPM6B","SMAD3","FLOT1","HEG1"]} {"pathway":"GO_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS","pval":0.88231,"padj":0.98086,"ES":0.49252,"NES":0.75048,"nMoreExtreme":62331,"size":51,"leadingEdge":["KLF4","MIR503","EGR3","ROBO1","PTGS2","SLIT2"]} {"pathway":"GO_AXON_DEVELOPMENT","pval":0.99962,"padj":1,"ES":0.4163,"NES":0.75027,"nMoreExtreme":95170,"size":416,"leadingEdge":["KREMEN1","EGR2","JAK2","SPTBN4","KLF4","SCARF1","NR4A3","NRCAM","B4GALT5","SEMA7A","UNC5C","NTN1","CXCL12","NR4A2","AUTS2","PAK1","SRC","VAX2","SEMA4A","NTNG2","ROBO1","ISL2","MAP2","RGMA","ADGRB1","EPHA10","GATA3","SEMA4D","SPTA1","SLIT2","BOC","TRIM46","NGF","C9orf72","FLOT1","RUFY3","PLPPR4","COBL","MCF2","LIMK1","NPTX1","SEMA3F"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_EXIT_FROM_ENDOPLASMIC_RETICULUM","pval":0.80806,"padj":0.96836,"ES":0.59081,"NES":0.75006,"nMoreExtreme":45611,"size":10,"leadingEdge":["EDEM1","EDEM2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_VASCULAR_PERMEABILITY","pval":0.81601,"padj":0.971,"ES":0.59232,"NES":0.75006,"nMoreExtreme":46593,"size":11,"leadingEdge":["CEACAM1","SLIT2","ADORA2A"]} {"pathway":"GO_GLYCEROLIPID_CATABOLIC_PROCESS","pval":0.8694,"padj":0.97662,"ES":0.50646,"NES":0.75003,"nMoreExtreme":59617,"size":42,"leadingEdge":["ENPP2","PLA2G4C","PLA2G4A","FABP4","GDE1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_WOUND_HEALING","pval":0.85979,"padj":0.97645,"ES":0.51599,"NES":0.74968,"nMoreExtreme":57837,"size":37,"leadingEdge":["PLEK","ENPP4","F3","NFE2L2","TLR4"]} {"pathway":"GO_RESPONSE_TO_LITHIUM_ION","pval":0.83033,"padj":0.97439,"ES":0.57547,"NES":0.74946,"nMoreExtreme":50518,"size":18,"leadingEdge":["ASCL1","LIG4","PTGS2","FABP4","CDH1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_AXON_EXTENSION","pval":0.85902,"padj":0.97645,"ES":0.51783,"NES":0.74917,"nMoreExtreme":57544,"size":36,"leadingEdge":["SEMA7A","NTN1","CXCL12","PAK1","RUFY3","LIMK1","TNFRSF12A"]} {"pathway":"GO_RNA_POLYMERASE_II_PREINITIATION_COMPLEX_ASSEMBLY","pval":0.83901,"padj":0.97458,"ES":0.5489,"NES":0.74905,"nMoreExtreme":53447,"size":25,"leadingEdge":["GTF2B","PSMC4"]} {"pathway":"GO_MEDIUM_CHAIN_FATTY_ACID_CATABOLIC_PROCESS","pval":0.61924,"padj":0.94878,"ES":0.50834,"NES":0.74893,"nMoreExtreme":31656,"size":3,"leadingEdge":["ACADM","ABHD2","ABHD3"]} {"pathway":"GO_ECTODERM_DEVELOPMENT","pval":0.83048,"padj":0.97439,"ES":0.57909,"NES":0.74889,"nMoreExtreme":50185,"size":17,"leadingEdge":["VAX2","ITGA6"]} {"pathway":"GO_CELL_CELL_JUNCTION_ASSEMBLY","pval":0.93549,"padj":0.98762,"ES":0.45597,"NES":0.74883,"nMoreExtreme":73118,"size":97,"leadingEdge":["AGT","GJD3","MARVELD2","ANK2","TNF","RUNX1","HEG1","LSR"]} {"pathway":"GO_CITRATE_TRANSPORT","pval":0.61985,"padj":0.94878,"ES":0.50795,"NES":0.74835,"nMoreExtreme":31687,"size":3,"leadingEdge":["SLC25A1","SFXN5","SLC13A3"]} {"pathway":"GO_HEART_FIELD_SPECIFICATION","pval":0.81716,"padj":0.97133,"ES":0.59095,"NES":0.74832,"nMoreExtreme":46659,"size":11,"leadingEdge":["ROBO1","SMARCD3"]} {"pathway":"GO_DENDRITIC_CELL_MIGRATION","pval":0.84014,"padj":0.97458,"ES":0.54828,"NES":0.7482,"nMoreExtreme":53519,"size":25,"leadingEdge":["SLAMF8","CCL5","IL12A","CCR5","CCL19","CCR6","GAS6","CCR1"]} {"pathway":"GO_SEQUESTERING_OF_METAL_ION","pval":0.80936,"padj":0.96934,"ES":0.58925,"NES":0.74807,"nMoreExtreme":45684,"size":10,"leadingEdge":["SRI","SLC30A4"]} {"pathway":"GO_MUSCLE_TISSUE_DEVELOPMENT","pval":0.99752,"padj":1,"ES":0.41999,"NES":0.74791,"nMoreExtreme":92005,"size":306,"leadingEdge":["VAMP5","EGR2","ATF3","AGT","PIM1","EDN1","MAFF","ASB2","MYH7","STAC3","SOX8","SLC8A1","IGSF8","PAK1","TGFB1","PDGFRA","ACTN2","RIPOR2","FOXC1","CFLAR","SMAD3","NUPR1","SIK1","MYOZ1","FOXN2","PAX5","HLX","FLOT1","HEG1","ALDH1A2","TBX1","PROX1"]} {"pathway":"GO_REGULATION_OF_DNA_REPAIR","pval":0.9507,"padj":0.99248,"ES":0.44762,"NES":0.74786,"nMoreExtreme":76519,"size":116,"leadingEdge":["RMI2","PML","DTX3L","PARP3","PARP9","FGF10","CGAS","HELB"]} {"pathway":"GO_PYRIMIDINE_NUCLEOSIDE_METABOLIC_PROCESS","pval":0.67893,"padj":0.94976,"ES":0.54305,"NES":0.74701,"nMoreExtreme":35924,"size":5,"leadingEdge":["TYMP","ERH"]} {"pathway":"GO_DRUG_TRANSMEMBRANE_TRANSPORT","pval":0.8991,"padj":0.98394,"ES":0.47989,"NES":0.74686,"nMoreExtreme":65171,"size":60,"leadingEdge":["KCNJ10","AGT","SLC18A1","SLC25A22","SLC22A1","SLC7A2","SLC25A30","SLC31A1"]} {"pathway":"GO_KIDNEY_EPITHELIUM_DEVELOPMENT","pval":0.94989,"padj":0.99192,"ES":0.44797,"NES":0.74676,"nMoreExtreme":76209,"size":113,"leadingEdge":["STAT1","AGT","SOX8","MYO1E","PODXL","TGFB1","FOXC1","GATA3","SMAD3","SLIT2","HOXD11","WNT1","HNF1B","SIX1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_VITAMIN_D_BIOSYNTHETIC_PROCESS","pval":0.67931,"padj":0.94976,"ES":0.54221,"NES":0.74585,"nMoreExtreme":35944,"size":5,"leadingEdge":["CYP27B1","SNAI2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_VITAMIN_METABOLIC_PROCESS","pval":0.67931,"padj":0.94976,"ES":0.54221,"NES":0.74585,"nMoreExtreme":35944,"size":5,"leadingEdge":["CYP27B1","SNAI2"]} {"pathway":"GO_DICARBOXYLIC_ACID_TRANSPORT","pval":0.91138,"padj":0.98539,"ES":0.47169,"NES":0.74526,"nMoreExtreme":67343,"size":68,"leadingEdge":["P2RX7","KCNJ10","SLC25A22","KMO","ABCC2","GLS","SLC25A30","ADORA2A","TSPOAP1"]} {"pathway":"GO_GASTRIC_MOTILITY","pval":0.68364,"padj":0.94976,"ES":0.49943,"NES":0.74493,"nMoreExtreme":34354,"size":2,"leadingEdge":["TYMP"]} {"pathway":"GO_REGULATION_OF_GASTRIC_MOTILITY","pval":0.68364,"padj":0.94976,"ES":0.49943,"NES":0.74493,"nMoreExtreme":34354,"size":2,"leadingEdge":["TYMP"]} {"pathway":"GO_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS","pval":0.93235,"padj":0.98762,"ES":0.45858,"NES":0.74475,"nMoreExtreme":71647,"size":87,"leadingEdge":["PDE4B","TYMP","ADA2","ENTPD2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_GLIAL_CELL_PROLIFERATION","pval":0.83445,"padj":0.97443,"ES":0.57583,"NES":0.74467,"nMoreExtreme":50425,"size":17,"leadingEdge":["LYN","LTA","IL6","TNF","UFL1"]} {"pathway":"GO_PHOSPHATIDYLINOSITOL_ACYL_CHAIN_REMODELING","pval":0.75751,"padj":0.9603,"ES":0.56876,"NES":0.74399,"nMoreExtreme":41174,"size":7,"leadingEdge":["PLAAT3","PLA2G4C","PLA2G4A"]} {"pathway":"GO_RENAL_SYSTEM_DEVELOPMENT","pval":0.99582,"padj":1,"ES":0.42187,"NES":0.74392,"nMoreExtreme":89602,"size":251,"leadingEdge":["LRRK2","STAT1","AGT","OVOL1","BCL2L11","GCNT3","AMER1","PRKX","FGF10","SOX8","MYO1E","PODXL","TGFB1","PDGFRA","CDKN1C","PKHD1","HAS2","FOXC1","CFLAR","GATA3","NKX3-1","LIN28A","PDGFB","SMAD3","SLIT2","HOXD11","ARID5B","ASS1","ALDH1A2"]} {"pathway":"GO_BONE_MINERALIZATION","pval":0.93885,"padj":0.98783,"ES":0.45541,"NES":0.74386,"nMoreExtreme":72769,"size":92,"leadingEdge":["P2RX7","SNX10","SBNO2","COMP","SLC8A1","SMPD3","CYP27B1","TGFB1","ISG15","GPM6B","PTGS2","CCL3","SMAD3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT","pval":0.96793,"padj":0.99587,"ES":0.43905,"NES":0.7437,"nMoreExtreme":79881,"size":136,"leadingEdge":["ZC3H12A","EDEM1","PAK1","TGFB1","PTGS2","GAS6","SMAD3","STOM","PRR5L","RUFY3","EDEM2"]} {"pathway":"GO_REGULATION_OF_NATURAL_KILLER_CELL_CHEMOTAXIS","pval":0.75762,"padj":0.9603,"ES":0.56853,"NES":0.74369,"nMoreExtreme":41180,"size":7,"leadingEdge":["CCL7","CCL5","CCL4","CCL2","CCL3"]} {"pathway":"GO_MYELOID_CELL_DEVELOPMENT","pval":0.89787,"padj":0.98354,"ES":0.4832,"NES":0.74345,"nMoreExtreme":64099,"size":55,"leadingEdge":["BCL6","NOTCH2","LILRB1","SRC","PAFAH1B1"]} {"pathway":"GO_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY","pval":0.98234,"padj":0.99935,"ES":0.43088,"NES":0.74316,"nMoreExtreme":83978,"size":174,"leadingEdge":["CHRD","ONECUT2","FGF10","HTRA4","CHST11","FST","TGFB1","CDKN1C","SMAD3"]} {"pathway":"GO_OXALOACETATE_METABOLIC_PROCESS","pval":0.72342,"padj":0.95562,"ES":0.55545,"NES":0.74273,"nMoreExtreme":38825,"size":6,"leadingEdge":["MDH1","NIT2","GOT1","GOT2","ACLY","MDH2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_BONE_MINERALIZATION","pval":0.8655,"padj":0.97662,"ES":0.51787,"NES":0.74242,"nMoreExtreme":57456,"size":34,"leadingEdge":["P2RX7","SLC8A1","TGFB1","ISG15","GPM6B","SMAD3"]} {"pathway":"GO_FACE_DEVELOPMENT","pval":0.88359,"padj":0.98086,"ES":0.49585,"NES":0.74239,"nMoreExtreme":61344,"size":45,"leadingEdge":["TGFB1","CRISPLD1","PDGFRA","CRISPLD2","ARID5B","ALDH1A2","TBX1"]} {"pathway":"GO_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION","pval":0.92726,"padj":0.987,"ES":0.46313,"NES":0.74139,"nMoreExtreme":69762,"size":76,"leadingEdge":["GLIPR2","IL6","HPN","TGFB1","FOXC1","SMAD3"]} {"pathway":"GO_REGULATION_OF_ENDOTHELIAL_CELL_DIFFERENTIATION","pval":0.85149,"padj":0.97645,"ES":0.5366,"NES":0.7412,"nMoreExtreme":54750,"size":27,"leadingEdge":["CEACAM1","TNF","FOXJ2"]} {"pathway":"GO_PARAXIAL_MESODERM_DEVELOPMENT","pval":0.83509,"padj":0.97443,"ES":0.58185,"NES":0.74046,"nMoreExtreme":49153,"size":14,"leadingEdge":["FOXC1","SMAD3","NUP133"]} {"pathway":"GO_SYNAPTIC_TRANSMISSION_CHOLINERGIC","pval":0.83973,"padj":0.97458,"ES":0.5683,"NES":0.74013,"nMoreExtreme":51090,"size":18,"leadingEdge":["COLQ","RAPSN","ADORA2A"]} {"pathway":"GO_SKIN_DEVELOPMENT","pval":0.98741,"padj":1,"ES":0.42769,"NES":0.73984,"nMoreExtreme":84958,"size":181,"leadingEdge":["OVOL1","COMP","CTSL","FGF10","LTB","TNF","FST","CYP27B1","RUNX1","TXNIP","FOXC1","ZFP36","EREG","MET"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_TARGETING_TO_MEMBRANE","pval":0.85331,"padj":0.97645,"ES":0.53558,"NES":0.7398,"nMoreExtreme":54867,"size":27,"leadingEdge":["PAK1","STOM","FYN"]} {"pathway":"GO_MAMMARY_GLAND_INVOLUTION","pval":0.72439,"padj":0.95562,"ES":0.55311,"NES":0.7396,"nMoreExtreme":38877,"size":6,"leadingEdge":["CAPN1","BAX","CAV1","VDR","IGFBP5"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MACROPHAGE_DIFFERENTIATION","pval":0.82953,"padj":0.97439,"ES":0.584,"NES":0.73953,"nMoreExtreme":47849,"size":12,"leadingEdge":["CSF1","TGFB1","CASP8"]} {"pathway":"GO_REGULATION_OF_GLUCOSE_TRANSMEMBRANE_TRANSPORT","pval":0.90988,"padj":0.98498,"ES":0.47564,"NES":0.73854,"nMoreExtreme":65726,"size":59,"leadingEdge":["C3","EDN1","NR4A3","RSC1A1","TNF","RHOQ","NFE2L2","EDNRA"]} {"pathway":"GO_PEPTIDOGLYCAN_CATABOLIC_PROCESS","pval":0.69102,"padj":0.94995,"ES":0.49466,"NES":0.73782,"nMoreExtreme":34725,"size":2,"leadingEdge":["LYG1","PGLYRP2"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_RADIATION","pval":0.98332,"padj":0.99955,"ES":0.43078,"NES":0.7375,"nMoreExtreme":82893,"size":156,"leadingEdge":["CARD16","TMEM109","TANK","GUCA1A","TGFB1","CDKN1A","NAMPT","LIG4","PTGS2","GATA3","BAK1","PTN"]} {"pathway":"GO_SARCOPLASMIC_RETICULUM_CALCIUM_ION_TRANSPORT","pval":0.85296,"padj":0.97645,"ES":0.54023,"NES":0.73721,"nMoreExtreme":54336,"size":25,"leadingEdge":["CAMK2D","SRI","ANK2","SLC8A1","CCR5","CCL3","CLIC2"]} {"pathway":"GO_HISTONE_DEPHOSPHORYLATION","pval":0.68207,"padj":0.94976,"ES":0.53563,"NES":0.7368,"nMoreExtreme":36090,"size":5,"leadingEdge":["EYA2","PPM1F","EYA1","EYA4"]} {"pathway":"GO_FATTY_ACID_DERIVATIVE_BIOSYNTHETIC_PROCESS","pval":0.89406,"padj":0.98309,"ES":0.49036,"NES":0.73658,"nMoreExtreme":62229,"size":46,"leadingEdge":["ACSL1","GGT5","ACSL5","ELOVL7","ELOVL5"]} {"pathway":"GO_NEPHRIC_DUCT_MORPHOGENESIS","pval":0.81593,"padj":0.971,"ES":0.57996,"NES":0.73628,"nMoreExtreme":46055,"size":10,"leadingEdge":["GATA3","HNF1B"]} {"pathway":"GO_RETINAL_CONE_CELL_DIFFERENTIATION","pval":0.68239,"padj":0.94976,"ES":0.53517,"NES":0.73616,"nMoreExtreme":36107,"size":5,"leadingEdge":["RORB","THY1"]} {"pathway":"GO_STORE_OPERATED_CALCIUM_ENTRY","pval":0.84169,"padj":0.97458,"ES":0.57302,"NES":0.73613,"nMoreExtreme":50419,"size":16,"leadingEdge":["JPH4","SPINK1","CD84"]} {"pathway":"GO_DETECTION_OF_MECHANICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_PAIN","pval":0.7851,"padj":0.96311,"ES":0.5703,"NES":0.7361,"nMoreExtreme":43259,"size":8,"leadingEdge":["CXCL12","FYN"]} {"pathway":"GO_BIOMINERAL_TISSUE_DEVELOPMENT","pval":0.96898,"padj":0.99598,"ES":0.43955,"NES":0.7355,"nMoreExtreme":78192,"size":118,"leadingEdge":["P2RX7","SNX10","FAM20A","SBNO2","COMP","SLC8A1","SMPD3","CYP27B1","TGFB1","ISG15","GPM6B","PTGS2","GAS6","CCL3","SMAD3"]} {"pathway":"GO_FIBROBLAST_APOPTOTIC_PROCESS","pval":0.8454,"padj":0.97458,"ES":0.56375,"NES":0.7342,"nMoreExtreme":51435,"size":18,"leadingEdge":["BCL2L11","GAS6","BAK1","BID"]} {"pathway":"GO_VENTRICULAR_SYSTEM_DEVELOPMENT","pval":0.8584,"padj":0.97645,"ES":0.53468,"NES":0.73409,"nMoreExtreme":54922,"size":26,"leadingEdge":["RAPGEF2","PAX5","MNAT1"]} {"pathway":"GO_LEUKOTRIENE_SIGNALING_PATHWAY","pval":0.68334,"padj":0.94976,"ES":0.53308,"NES":0.73329,"nMoreExtreme":36157,"size":5,"leadingEdge":["CYSLTR2","RGS1"]} {"pathway":"GO_NEURAL_NUCLEUS_DEVELOPMENT","pval":0.90248,"padj":0.98417,"ES":0.48516,"NES":0.7331,"nMoreExtreme":63186,"size":48,"leadingEdge":["PADI2","SYNGR3","ASCL1","CASP5","CKB","S100A1"]} {"pathway":"GO_REGULATION_OF_SYNAPTIC_VESICLE_CYCLE","pval":0.95413,"padj":0.9932,"ES":0.44878,"NES":0.73303,"nMoreExtreme":73954,"size":92,"leadingEdge":["LRRK2","GRIN3A","DTNBP1","NAPA","ADORA2A"]} {"pathway":"GO_HISTONE_MONOUBIQUITINATION","pval":0.86635,"padj":0.97662,"ES":0.52453,"NES":0.73282,"nMoreExtreme":56220,"size":29,"leadingEdge":["DTX3L","PCGF5","PAF1"]} {"pathway":"GO_MALE_MATING_BEHAVIOR","pval":0.72633,"padj":0.95562,"ES":0.54769,"NES":0.73236,"nMoreExtreme":38981,"size":6,"leadingEdge":["NCOA1","HDAC4","HEXB"]} {"pathway":"GO_PENETRATION_OF_ZONA_PELLUCIDA","pval":0.63343,"padj":0.94878,"ES":0.49709,"NES":0.73235,"nMoreExtreme":32381,"size":3,"leadingEdge":["HEXB","B4GALT1"]} {"pathway":"GO_REGULATION_OF_ICOSANOID_SECRETION","pval":0.83913,"padj":0.97458,"ES":0.5778,"NES":0.73218,"nMoreExtreme":48871,"size":13,"leadingEdge":["P2RX7","P2RX4","EDN1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_FATTY_ACID_TRANSPORT","pval":0.83913,"padj":0.97458,"ES":0.5778,"NES":0.73218,"nMoreExtreme":48871,"size":13,"leadingEdge":["P2RX7","P2RX4","EDN1"]} {"pathway":"GO_MESENCHYMAL_CELL_DIFFERENTIATION","pval":0.9939,"padj":1,"ES":0.42403,"NES":0.73217,"nMoreExtreme":85184,"size":177,"leadingEdge":["HGF","STAT1","EDN1","GLIPR2","AMER1","IL6","FGF10","SEMA7A","SOX8","HPN","TGFB1","SEMA4A","HAS2","FOXC1","SEMA4D","SMAD3","EDNRA","ALDH1A2","TBX1"]} {"pathway":"GO_IRON_ION_HOMEOSTASIS","pval":0.93293,"padj":0.98762,"ES":0.4617,"NES":0.73209,"nMoreExtreme":69279,"size":70,"leadingEdge":["ATP13A2","STEAP4","SRI","B2M","SLC25A28","CUL1","ATP6V1A","NCOA4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_BLOOD_PRESSURE","pval":0.84978,"padj":0.97645,"ES":0.55787,"NES":0.73152,"nMoreExtreme":52191,"size":19,"leadingEdge":["AGT","TBXA2R"]} {"pathway":"GO_REGULATION_OF_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY","pval":0.97726,"padj":0.99889,"ES":0.4349,"NES":0.73143,"nMoreExtreme":79615,"size":125,"leadingEdge":["P2RX7","STAT3","PRELID1","ESRRB","HDAC4"]} {"pathway":"GO_ADRENERGIC_RECEPTOR_SIGNALING_PATHWAY","pval":0.8461,"padj":0.97477,"ES":0.56933,"NES":0.7314,"nMoreExtreme":50683,"size":16,"leadingEdge":["RAPGEF2","ATP2B4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING","pval":0.98189,"padj":0.99935,"ES":0.43245,"NES":0.73115,"nMoreExtreme":80722,"size":133,"leadingEdge":["HGF","CD80","P2RX4","NRG4","FGF10","TXN","TNF","CD86","PIK3AP1","CHI3L1","F3","P2RY12","NRG2","SRC","TGFB1","ICOS","CCL19","PDGFRA","GAS6","CCL3","CX3CL1","GATA3","LIN28A","PDGFB"]} {"pathway":"GO_TELENCEPHALON_DEVELOPMENT","pval":0.99795,"padj":1,"ES":0.41968,"NES":0.73093,"nMoreExtreme":87112,"size":201,"leadingEdge":["LRRK2","BCL2A1","ATF5","NR4A3","ANXA3","SEMA7A","SLC8A1","NCOA1","ASCL1","CXCL12","P2RY12","ROBO1","LPAR1","MFSD2A","PLCB1","SLIT2","PAX5"]} {"pathway":"GO_REGULATION_OF_PH","pval":0.9459,"padj":0.9905,"ES":0.45447,"NES":0.7307,"nMoreExtreme":71615,"size":79,"leadingEdge":["LRRK2","RAB20","EDN1","SLAMF8","SLC4A10","ATP6V1A","RAB38","RAB39A","SLC9A4"]} {"pathway":"GO_HEPATOCYTE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY","pval":0.84573,"padj":0.97477,"ES":0.57175,"NES":0.7305,"nMoreExtreme":50255,"size":15,"leadingEdge":["HGF","HPN","PTPN2","PAK1","PTPN1","ESM1","MET"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION","pval":0.86722,"padj":0.97662,"ES":0.52556,"NES":0.73037,"nMoreExtreme":56020,"size":28,"leadingEdge":["STAT1","STAT3","ISG15"]} {"pathway":"GO_REGULATION_OF_ORGAN_GROWTH","pval":0.94622,"padj":0.9905,"ES":0.45472,"NES":0.72996,"nMoreExtreme":71473,"size":78,"leadingEdge":["PIM1","BCL2L11","EDN1","IL7","PAK1","FOXC1","HLX","PROX1","MAPK11","WWC3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CYTOPLASMIC_MRNA_PROCESSING_BODY_ASSEMBLY","pval":0.68479,"padj":0.94976,"ES":0.53025,"NES":0.7294,"nMoreExtreme":36234,"size":5,"leadingEdge":["CNOT6","CNOT1","PAN2","CNOT6L","PAN3"]} {"pathway":"GO_VASCULAR_ENDOTHELIAL_CELL_PROLIFERATION","pval":0.84812,"padj":0.97587,"ES":0.56761,"NES":0.72919,"nMoreExtreme":50804,"size":16,"leadingEdge":["MIR503","FLT1","CCL2","STAT3","MEF2C"]} {"pathway":"GO_REGULATION_OF_MEMBRANE_TUBULATION","pval":0.7275,"padj":0.9559,"ES":0.54513,"NES":0.72894,"nMoreExtreme":39044,"size":6,"leadingEdge":["DNM2","SH3GLB1","WASL","SH3GL2","PLEKHM2"]} {"pathway":"GO_PEPTIDE_MODIFICATION","pval":0.63656,"padj":0.94878,"ES":0.49469,"NES":0.72882,"nMoreExtreme":32541,"size":3,"leadingEdge":["GGT1","PAM","PGLYRP2"]} {"pathway":"GO_ACYLGLYCEROL_ACYL_CHAIN_REMODELING","pval":0.68494,"padj":0.94976,"ES":0.52978,"NES":0.72876,"nMoreExtreme":36242,"size":5,"leadingEdge":["DGAT2","MGLL"]} {"pathway":"GO_REGULATION_OF_FATTY_ACID_TRANSPORT","pval":0.85546,"padj":0.97645,"ES":0.55158,"NES":0.7282,"nMoreExtreme":52879,"size":20,"leadingEdge":["P2RX7","P2RX4","EDN1"]} {"pathway":"GO_PROTEIN_DEGLYCOSYLATION","pval":0.86989,"padj":0.97681,"ES":0.52397,"NES":0.72816,"nMoreExtreme":56192,"size":28,"leadingEdge":["EDEM1","EDEM2","MAN2B2"]} {"pathway":"GO_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL_BY_ENDOPLASMIC_RETICULUM","pval":0.86037,"padj":0.97645,"ES":0.54023,"NES":0.72802,"nMoreExtreme":54132,"size":23,"leadingEdge":["CAMK2D","SRI","ANK2","SLC8A1","CCR5","CCL3","CLIC2"]} {"pathway":"GO_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE","pval":0.86368,"padj":0.97662,"ES":0.53346,"NES":0.72797,"nMoreExtreme":55019,"size":25,"leadingEdge":["BCL2L11","PTPN2","PTPN1","BAK1"]} {"pathway":"GO_MAINTENANCE_OF_CELL_NUMBER","pval":0.98536,"padj":0.99994,"ES":0.4305,"NES":0.72733,"nMoreExtreme":80913,"size":132,"leadingEdge":["ASCL2","KLF4","FGF10","NOTCH2","STAT3","LIG4","LIN28A","ESRRB","PROX1","SOX2","HNF1B"]} {"pathway":"GO_LIPOPROTEIN_CATABOLIC_PROCESS","pval":0.83142,"padj":0.97439,"ES":0.57387,"NES":0.7267,"nMoreExtreme":47473,"size":11,"leadingEdge":["LYPLA2","ABHD12","ABHD17B","LYPLA1","ABHD17A","LDLR","APOE","PPT1","ABHD17C","ABHD13","LYPLAL1"]} {"pathway":"GO_OXYGEN_TRANSPORT","pval":0.63849,"padj":0.94878,"ES":0.49323,"NES":0.72667,"nMoreExtreme":32640,"size":3,"leadingEdge":["IPCEF1","MYC","CYGB"]} {"pathway":"GO_ADENYLATE_CYCLASE_INHIBITING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY","pval":0.91718,"padj":0.987,"ES":0.47583,"NES":0.72663,"nMoreExtreme":64932,"size":52,"leadingEdge":["SSTR2","GRM8","EDN1","FPR2","P2RY12","AKAP12","LPAR1","RGS1","EDNRA"]} {"pathway":"GO_AXON_EXTENSION","pval":0.9727,"padj":0.99756,"ES":0.43876,"NES":0.72646,"nMoreExtreme":77150,"size":105,"leadingEdge":["NRCAM","SEMA7A","NTN1","CXCL12","AUTS2","PAK1","SEMA4A","MAP2","SEMA4D","SLIT2","TRIM46","C9orf72","RUFY3","LIMK1","SEMA3F","SEMA3E"]} {"pathway":"GO_RECEPTOR_CLUSTERING","pval":0.90832,"padj":0.9845,"ES":0.48345,"NES":0.72621,"nMoreExtreme":63222,"size":46,"leadingEdge":["COLQ","ITGAL","ITGB7","TGFB1","SHISA7","PTN","DLG3"]} {"pathway":"GO_NATURAL_KILLER_CELL_CHEMOTAXIS","pval":0.80808,"padj":0.96836,"ES":0.56853,"NES":0.72618,"nMoreExtreme":45158,"size":9,"leadingEdge":["CCL7","CCL5","CCL4","CCL2","CCL3"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_IRON_ION","pval":0.83177,"padj":0.97439,"ES":0.57337,"NES":0.72606,"nMoreExtreme":47493,"size":11,"leadingEdge":["B2M","HFE"]} {"pathway":"GO_POSITIVE_REGULATION_OF_HEXOKINASE_ACTIVITY","pval":0.68606,"padj":0.94976,"ES":0.52767,"NES":0.72585,"nMoreExtreme":36301,"size":5,"leadingEdge":["BAD","TIGAR","DUSP12","PFKFB2","RANBP2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CHROMATIN_BINDING","pval":0.76429,"padj":0.96082,"ES":0.55481,"NES":0.72573,"nMoreExtreme":41543,"size":7,"leadingEdge":["WAPL","BTAF1","NFATC4","FBH1","PPP3CA","TDG","MEPCE"]} {"pathway":"GO_REGULATION_OF_STORE_OPERATED_CALCIUM_ENTRY","pval":0.83196,"padj":0.97439,"ES":0.57304,"NES":0.72565,"nMoreExtreme":47504,"size":11,"leadingEdge":["JPH4","SPINK1","CD84"]} {"pathway":"GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_SYNAPSE","pval":0.86189,"padj":0.97645,"ES":0.5418,"NES":0.72537,"nMoreExtreme":53929,"size":22,"leadingEdge":["CLSTN3","ARHGAP44"]} {"pathway":"GO_RESPONSE_TO_GONADOTROPIN","pval":0.85991,"padj":0.97645,"ES":0.54559,"NES":0.7253,"nMoreExtreme":53517,"size":21,"leadingEdge":["ICAM1","GCLC","ASNS","ITGA3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELL_GROWTH","pval":0.99464,"padj":1,"ES":0.42411,"NES":0.72524,"nMoreExtreme":83659,"size":154,"leadingEdge":["AGT","PML","NPR1","BCL6","SEMA7A","NTN1","CYP27B1","PAK1","TGFB1","SEMA4A","CDKN1A","MAP2","SEMA4D","SMAD3","SLIT2","TRIM46"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MYELOID_CELL_APOPTOTIC_PROCESS","pval":0.84006,"padj":0.97458,"ES":0.57207,"NES":0.72442,"nMoreExtreme":48456,"size":12,"leadingEdge":["NOD2","IRF7","CCR5","FCER1G"]} {"pathway":"GO_EMBRYONIC_NEUROCRANIUM_MORPHOGENESIS","pval":0.7649,"padj":0.96082,"ES":0.55353,"NES":0.72406,"nMoreExtreme":41576,"size":7,"leadingEdge":["NDST1","TULP3","MTHFD1","HOXA1","TGFB3","MTHFD1L"]} {"pathway":"GO_MEDIUM_CHAIN_FATTY_ACID_BIOSYNTHETIC_PROCESS","pval":0.64891,"padj":0.94878,"ES":0.50837,"NES":0.72394,"nMoreExtreme":33772,"size":4,"leadingEdge":["ACOT7","ABHD2","OXSM","ABHD3"]} {"pathway":"GO_RESPONSE_TO_FOLLICLE_STIMULATING_HORMONE","pval":0.83333,"padj":0.97443,"ES":0.57128,"NES":0.72341,"nMoreExtreme":47582,"size":11,"leadingEdge":["GCLC","ASNS","GCLM"]} {"pathway":"GO_GLUCAGON_SECRETION","pval":0.64914,"padj":0.94878,"ES":0.50796,"NES":0.72335,"nMoreExtreme":33784,"size":4,"leadingEdge":["IL6","SYT7"]} {"pathway":"GO_REGULATION_OF_MOTOR_NEURON_APOPTOTIC_PROCESS","pval":0.64931,"padj":0.94878,"ES":0.5077,"NES":0.72298,"nMoreExtreme":33793,"size":4,"leadingEdge":["MAP2K4","ZPR1","MAP3K12","KCNB1"]} {"pathway":"GO_DETECTION_OF_ABIOTIC_STIMULUS","pval":0.95266,"padj":0.99288,"ES":0.4523,"NES":0.72296,"nMoreExtreme":71535,"size":75,"leadingEdge":["CDS1","HPN","CXCL12","GUCA1A","PDZD7","PKD2L1"]} {"pathway":"GO_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY","pval":0.85198,"padj":0.97645,"ES":0.56574,"NES":0.72282,"nMoreExtreme":50626,"size":15,"leadingEdge":["TRIM72","NKX3-1","WNT1","IGF1"]} {"pathway":"GO_STRIATED_MUSCLE_CELL_PROLIFERATION","pval":0.92636,"padj":0.987,"ES":0.46974,"NES":0.72274,"nMoreExtreme":66133,"size":55,"leadingEdge":["JAK2","PIM1","STAT3","FOXC1","CFLAR","MAPK11","SIX1"]} {"pathway":"GO_MALE_SEX_DIFFERENTIATION","pval":0.98605,"padj":0.99994,"ES":0.43094,"NES":0.72264,"nMoreExtreme":79863,"size":121,"leadingEdge":["TNFSF10","ICAM1","BCL2L11","RHOBTB3","TLR3","FGF10","SOX8","NCOA1","PDGFRA","GATA3","NKX3-1","NUPR1","NCOA4","ARID5B"]} {"pathway":"GO_POSITIVE_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION","pval":0.72985,"padj":0.95607,"ES":0.54003,"NES":0.72212,"nMoreExtreme":39170,"size":6,"leadingEdge":["CCL5","LGALS1"]} {"pathway":"GO_RHYTHMIC_BEHAVIOR","pval":0.86838,"padj":0.97662,"ES":0.53235,"NES":0.72201,"nMoreExtreme":54995,"size":24,"leadingEdge":["EGR2","ADORA2A"]} {"pathway":"GO_METENCEPHALON_DEVELOPMENT","pval":0.96118,"padj":0.9934,"ES":0.446,"NES":0.72166,"nMoreExtreme":73439,"size":84,"leadingEdge":["SSTR2","NCOA1","ASCL1","PAK1","LPAR1","SEZ6L","FOXC1","CKB","PROX1","HAP1","PTN","WNT1","RERE"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR_VIA_HOMOLOGOUS_RECOMBINATION","pval":0.85806,"padj":0.97645,"ES":0.55377,"NES":0.7212,"nMoreExtreme":52205,"size":18,"leadingEdge":["RMI2","CGAS","HELB","TP53BP1"]} {"pathway":"GO_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT","pval":0.89551,"padj":0.98309,"ES":0.49846,"NES":0.72115,"nMoreExtreme":59988,"size":36,"leadingEdge":["STAT1","PRKX","MYO1E","PODXL","GATA3","PDGFB"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_GONADOTROPIN_SECRETION","pval":0.7077,"padj":0.9508,"ES":0.48349,"NES":0.72115,"nMoreExtreme":35563,"size":2,"leadingEdge":["INHBA","INHBB"]} {"pathway":"GO_REGULATION_OF_TRANSCRIPTION_BY_GLUCOSE","pval":0.65052,"padj":0.94878,"ES":0.50629,"NES":0.72098,"nMoreExtreme":33856,"size":4,"leadingEdge":["USF2","SRF","RRP8","USF1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_HYPOXIA_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY","pval":0.65064,"padj":0.94878,"ES":0.50607,"NES":0.72066,"nMoreExtreme":33862,"size":4,"leadingEdge":["ENO1","TMBIM6","HYOU1","PINK1"]} {"pathway":"GO_VESICLE_FUSION_TO_PLASMA_MEMBRANE","pval":0.85903,"padj":0.97645,"ES":0.55298,"NES":0.72017,"nMoreExtreme":52264,"size":18,"leadingEdge":["STX11","PRRT2","STX3"]} {"pathway":"GO_PROTEIN_TARGETING_TO_LYSOSOME","pval":0.86095,"padj":0.97645,"ES":0.54906,"NES":0.71997,"nMoreExtreme":52877,"size":19,"leadingEdge":["SNX16","NCOA4","GCC2","M6PR"]} {"pathway":"GO_POSITIVE_REGULATION_OF_DENDRITE_DEVELOPMENT","pval":0.94088,"padj":0.98812,"ES":0.4607,"NES":0.71968,"nMoreExtreme":68526,"size":62,"leadingEdge":["C21orf91","LPAR1","COBL","CDKL3"]} {"pathway":"GO_RESPONSE_TO_PROSTAGLANDIN","pval":0.86931,"padj":0.97662,"ES":0.53394,"NES":0.71953,"nMoreExtreme":54694,"size":23,"leadingEdge":["EDN1","PTGER4","PTGER2","CCL19","TNC"]} {"pathway":"GO_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION_INVOLVED_IN_LUNG_MORPHOGENESIS","pval":0.76656,"padj":0.96082,"ES":0.54986,"NES":0.71926,"nMoreExtreme":41666,"size":7,"leadingEdge":["FGFR2","WNT2","SRSF6","SOX9","FOXP2","FGF7","NFIB"]} {"pathway":"GO_SECRETION_BY_TISSUE","pval":0.87734,"padj":0.97965,"ES":0.52385,"NES":0.71922,"nMoreExtreme":56134,"size":26,"leadingEdge":["TIFAB","FGF10","NR1H3","P2RY2","NEUROG1"]} {"pathway":"GO_MONOAMINE_TRANSPORT","pval":0.92073,"padj":0.987,"ES":0.47579,"NES":0.71894,"nMoreExtreme":64464,"size":48,"leadingEdge":["AGT","SLC18A1","DTNBP1","CXCL12","LILRB1","P2RY12","SYT5","SLC22A1","GPM6B","SYT17","FCER1G","ADORA2A"]} {"pathway":"GO_PROTEIN_DESTABILIZATION","pval":0.91158,"padj":0.98541,"ES":0.48536,"NES":0.71878,"nMoreExtreme":62510,"size":42,"leadingEdge":["PYHIN1","SRC","TRIM21","CREBBP"]} {"pathway":"GO_REGULATION_OF_NEUROBLAST_PROLIFERATION","pval":0.86802,"padj":0.97662,"ES":0.54,"NES":0.71787,"nMoreExtreme":54022,"size":21,"leadingEdge":["LRRK2","VEGFC","TGFB1","CX3CL1","SMARCD3"]} {"pathway":"GO_IODIDE_TRANSPORT","pval":0.64593,"padj":0.94878,"ES":0.48703,"NES":0.71754,"nMoreExtreme":33020,"size":3,"leadingEdge":["TG","SLC26A4"]} {"pathway":"GO_DETECTION_OF_TEMPERATURE_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION","pval":0.82688,"padj":0.97439,"ES":0.56494,"NES":0.71721,"nMoreExtreme":46673,"size":10,"leadingEdge":["CXCL12","LXN"]} {"pathway":"GO_AMINOGLYCAN_BIOSYNTHETIC_PROCESS","pval":0.97892,"padj":0.99901,"ES":0.43661,"NES":0.71705,"nMoreExtreme":76512,"size":97,"leadingEdge":["SDC3","DSE","B4GALT5","CHST11","HS3ST3B1","SMPD3","TGFB1","CHST2","HAS2","HS3ST3A1","PDGFB","HS3ST2"]} {"pathway":"GO_INOSITOL_PHOSPHATE_BIOSYNTHETIC_PROCESS","pval":0.89939,"padj":0.98394,"ES":0.49777,"NES":0.71694,"nMoreExtreme":59945,"size":35,"leadingEdge":["PLEK","PTAFR","PLCB1","CD244"]} {"pathway":"GO_CHEMOKINE_SECRETION","pval":0.85835,"padj":0.97645,"ES":0.55805,"NES":0.71691,"nMoreExtreme":51417,"size":16,"leadingEdge":["MCOLN2","TNF","IL33"]} {"pathway":"GO_MALATE_METABOLIC_PROCESS","pval":0.73164,"padj":0.95656,"ES":0.53607,"NES":0.71682,"nMoreExtreme":39266,"size":6,"leadingEdge":["MDH1","ME1","ME2","FH","MDH2","ME3"]} {"pathway":"GO_SECONDARY_METABOLITE_BIOSYNTHETIC_PROCESS","pval":0.87071,"padj":0.97709,"ES":0.5354,"NES":0.7168,"nMoreExtreme":54481,"size":22,"leadingEdge":["RAPGEF2","CTNS","CBSL"]} {"pathway":"GO_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT","pval":0.91682,"padj":0.987,"ES":0.48025,"NES":0.71653,"nMoreExtreme":63432,"size":44,"leadingEdge":["STAT1","AMER1","PRKX","MYO1E","PODXL","GATA3","PDGFB"]} {"pathway":"GO_LOCALIZATION_WITHIN_MEMBRANE","pval":0.99309,"padj":1,"ES":0.42601,"NES":0.71648,"nMoreExtreme":80905,"size":125,"leadingEdge":["COLQ","ITGAL","PTPRC","ITGB7","TGFB1","RILPL1","STX3","SHISA7","ARC","PTN","KIF17","DLG3"]} {"pathway":"GO_FIBROBLAST_GROWTH_FACTOR_PRODUCTION","pval":0.76751,"padj":0.96082,"ES":0.54769,"NES":0.71642,"nMoreExtreme":41718,"size":7,"leadingEdge":["PTGS2","HEG1","CCM2L"]} {"pathway":"GO_REGULATION_OF_DNA_BINDING","pval":0.98531,"padj":0.99994,"ES":0.43175,"NES":0.71625,"nMoreExtreme":78387,"size":107,"leadingEdge":["JAK2","KLF4","SRI","PYHIN1","IRF4","TXN","TGFB1","NFKBIA","FOXC1","GATA3","NGF","GTF2B"]} {"pathway":"GO_DISTAL_TUBULE_DEVELOPMENT","pval":0.76768,"padj":0.96082,"ES":0.54728,"NES":0.71588,"nMoreExtreme":41727,"size":7,"leadingEdge":["PKD1","JAG1","PKD2","PAX8","WNK4","KLHL3","NOTCH1"]} {"pathway":"GO_SENSORY_PERCEPTION_OF_TEMPERATURE_STIMULUS","pval":0.85122,"padj":0.97645,"ES":0.56493,"NES":0.71587,"nMoreExtreme":49575,"size":13,"leadingEdge":["CXCL12","LXN"]} {"pathway":"GO_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR","pval":0.98348,"padj":0.99955,"ES":0.43359,"NES":0.71586,"nMoreExtreme":77628,"size":102,"leadingEdge":["CD74","MUC1","PML","PMAIP1","PYHIN1","NBN","CDKN1A"]} {"pathway":"GO_POSITIVE_REGULATION_OF_LIPID_TRANSPORT","pval":0.9257,"padj":0.987,"ES":0.47347,"NES":0.71543,"nMoreExtreme":64812,"size":48,"leadingEdge":["P2RX7","P2RX4","EDN1","LIPG","NR1H3","NFKBIA","PRELID1","NKX3-1"]} {"pathway":"GO_DETECTION_OF_TEMPERATURE_STIMULUS","pval":0.84602,"padj":0.97477,"ES":0.56494,"NES":0.71539,"nMoreExtreme":48800,"size":12,"leadingEdge":["CXCL12","LXN"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS","pval":0.85793,"padj":0.97645,"ES":0.55981,"NES":0.71524,"nMoreExtreme":50980,"size":15,"leadingEdge":["PADI2","STAP1","SLAMF8","GPR18","CCL2","SLIT2"]} {"pathway":"GO_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION","pval":0.95176,"padj":0.99278,"ES":0.45506,"NES":0.71504,"nMoreExtreme":69841,"size":65,"leadingEdge":["LRRK2","VEGFC","LYN","CTSZ","ASCL1","TRIM71","TGFB1","CX3CL1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION","pval":0.96761,"padj":0.99587,"ES":0.44404,"NES":0.71488,"nMoreExtreme":73427,"size":80,"leadingEdge":["VEGFC","MIR503","DYSF","EGR3","STAT5A","CXCL12","F3","STAT3","PDGFB","PPP1R16B","PROX1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION","pval":0.88873,"padj":0.98088,"ES":0.51132,"NES":0.71436,"nMoreExtreme":57672,"size":29,"leadingEdge":["PAK1","MET","SPAST"]} {"pathway":"GO_REGULATION_OF_CHROMATIN_BINDING","pval":0.87032,"padj":0.97692,"ES":0.54085,"NES":0.71404,"nMoreExtreme":53798,"size":20,"leadingEdge":["DTX3L","PARP9","KDM1A"]} {"pathway":"GO_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS","pval":0.95988,"padj":0.9934,"ES":0.44953,"NES":0.714,"nMoreExtreme":71437,"size":71,"leadingEdge":["TNF","CYP27B1","ERLIN1","INSIG2","PROX1","NFYA"]} {"pathway":"GO_POSTTRANSLATIONAL_PROTEIN_TARGETING_TO_ENDOPLASMIC_RETICULUM_MEMBRANE","pval":0.82867,"padj":0.97439,"ES":0.56231,"NES":0.71387,"nMoreExtreme":46774,"size":10,"leadingEdge":["SEC62","SEC63","HSPA5","SEC61A1","SEC61A2","CHMP4B","SGTA","SEC61B"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_FLUID_SHEAR_STRESS","pval":0.86529,"padj":0.97662,"ES":0.5481,"NES":0.71382,"nMoreExtreme":52645,"size":18,"leadingEdge":["KLF4","SRC","PTGS2","HAS2","NFE2L2","ASS1"]} {"pathway":"GO_CELL_CELL_RECOGNITION","pval":0.91949,"padj":0.987,"ES":0.48106,"NES":0.71242,"nMoreExtreme":63052,"size":42,"leadingEdge":["CCL19","HVCN1","ASTL","CD6"]} {"pathway":"GO_BONE_REMODELING","pval":0.9563,"padj":0.9934,"ES":0.45239,"NES":0.71236,"nMoreExtreme":70358,"size":66,"leadingEdge":["P2RX7","SNX10","CD38","IL7","TNFAIP3","IL6","NOTCH2","SRC","TGFB1","PPARGC1B"]} {"pathway":"GO_REGULATION_OF_GONADOTROPIN_SECRETION","pval":0.6505,"padj":0.94878,"ES":0.48351,"NES":0.71236,"nMoreExtreme":33254,"size":3,"leadingEdge":["INHBA","SMAD4","INHBB"]} {"pathway":"GO_POSITIVE_REGULATION_OF_GONADOTROPIN_SECRETION","pval":0.6505,"padj":0.94878,"ES":0.48351,"NES":0.71236,"nMoreExtreme":33254,"size":3,"leadingEdge":["INHBA","SMAD4","INHBB"]} {"pathway":"GO_ACYLGLYCEROL_METABOLIC_PROCESS","pval":0.92031,"padj":0.987,"ES":0.47926,"NES":0.71232,"nMoreExtreme":63370,"size":43,"leadingEdge":["GK","PLAAT3","DGAT2","DGKG","LMF1","INSIG2","CPT1A"]} {"pathway":"GO_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS","pval":0.65561,"padj":0.94878,"ES":0.50006,"NES":0.7121,"nMoreExtreme":34121,"size":4,"leadingEdge":["RORA","PTHLH","EPHA2","PDE9A"]} {"pathway":"GO_PROTEIN_INSERTION_INTO_MEMBRANE","pval":0.93936,"padj":0.98783,"ES":0.46535,"NES":0.71063,"nMoreExtreme":66502,"size":52,"leadingEdge":["RTP4","BCL2L11","PMAIP1","BBC3"]} {"pathway":"GO_REPLICATION_FORK_ARREST","pval":0.6925,"padj":0.94995,"ES":0.51597,"NES":0.70976,"nMoreExtreme":36642,"size":5,"leadingEdge":["TIPIN","TIMELESS","MSH3","MSH6"]} {"pathway":"GO_ASTROCYTE_DEVELOPMENT","pval":0.90765,"padj":0.98435,"ES":0.4946,"NES":0.70907,"nMoreExtreme":60254,"size":34,"leadingEdge":["IL6","TNF","FPR2","TLR4","ADORA2A"]} {"pathway":"GO_REGULATION_OF_LIPID_TRANSPORTER_ACTIVITY","pval":0.72069,"padj":0.95459,"ES":0.47501,"NES":0.7085,"nMoreExtreme":36216,"size":2,"leadingEdge":["PPARG","PRKCD"]} {"pathway":"GO_NEURAL_PRECURSOR_CELL_PROLIFERATION","pval":0.99634,"padj":1,"ES":0.42352,"NES":0.70814,"nMoreExtreme":80309,"size":117,"leadingEdge":["LRRK2","ATF5","VEGFC","LYN","CTSZ","ASCL1","TRIM71","TGFB1","CX3CL1"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_XENOBIOTIC_STIMULUS","pval":0.99302,"padj":1,"ES":0.42683,"NES":0.70809,"nMoreExtreme":79001,"size":107,"leadingEdge":["ACSL1","CYP1A1","ICAM1","APOBEC3A","CBR3","EPHX1","SLC8A1","TGFB1","CES1","CFLAR","PDGFB"]} {"pathway":"GO_INNER_EAR_MORPHOGENESIS","pval":0.96315,"padj":0.995,"ES":0.44883,"NES":0.70803,"nMoreExtreme":71042,"size":67,"leadingEdge":["TIFAB","NR4A3","FGF10","HPN","NTN1","GATA3","PDZD7","INSIG2","TBX1","PROX1","NEUROG1","WNT1","SIX1"]} {"pathway":"GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION","pval":0.90469,"padj":0.98417,"ES":0.49887,"NES":0.70802,"nMoreExtreme":59494,"size":32,"leadingEdge":["GTF2B","HNF1B","PSMC4"]} {"pathway":"GO_SERINE_FAMILY_AMINO_ACID_METABOLIC_PROCESS","pval":0.90222,"padj":0.98417,"ES":0.50154,"NES":0.70797,"nMoreExtreme":59063,"size":31,"leadingEdge":["GGT5","SDSL","GCLC","SEPHS2","CBSL","SDS"]} {"pathway":"GO_MUSCLE_FIBER_DEVELOPMENT","pval":0.9364,"padj":0.98783,"ES":0.46822,"NES":0.70751,"nMoreExtreme":65561,"size":48,"leadingEdge":["MYOF","COMP","DYSF","STAC3","RIPOR2","HDAC4","SIX1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_REGENERATION","pval":0.65616,"padj":0.94878,"ES":0.47969,"NES":0.70673,"nMoreExtreme":33543,"size":3,"leadingEdge":["CAPN3","PPARD","TGFBR2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT","pval":0.91776,"padj":0.987,"ES":0.48428,"NES":0.70659,"nMoreExtreme":62056,"size":38,"leadingEdge":["P2RX7","SLC8A1","TGFB1","ISG15","GPM6B","SMAD3"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_CAFFEINE","pval":0.69386,"padj":0.94995,"ES":0.51349,"NES":0.70635,"nMoreExtreme":36714,"size":5,"leadingEdge":["SLC8A1","TMEM38B"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_PARANODE_REGION_OF_AXON","pval":0.65664,"padj":0.94878,"ES":0.4793,"NES":0.70615,"nMoreExtreme":33568,"size":3,"leadingEdge":["EPB41L3","CNTNAP1","NFASC"]} {"pathway":"GO_CRANIAL_NERVE_STRUCTURAL_ORGANIZATION","pval":0.79808,"padj":0.96646,"ES":0.5464,"NES":0.70524,"nMoreExtreme":43974,"size":8,"leadingEdge":["EGR2","SEMA3F"]} {"pathway":"GO_FACIAL_NERVE_STRUCTURAL_ORGANIZATION","pval":0.79808,"padj":0.96646,"ES":0.5464,"NES":0.70524,"nMoreExtreme":43974,"size":8,"leadingEdge":["EGR2","SEMA3F"]} {"pathway":"GO_RENAL_TUBULE_DEVELOPMENT","pval":0.9763,"padj":0.99861,"ES":0.43994,"NES":0.70514,"nMoreExtreme":73565,"size":77,"leadingEdge":["STAT1","AGT","SOX8","TGFB1","GATA3","HOXD11","WNT1","HNF1B","SIX1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR","pval":0.90564,"padj":0.98417,"ES":0.49942,"NES":0.70499,"nMoreExtreme":59287,"size":31,"leadingEdge":["DTX3L","PARP3","PARP9","WAS"]} {"pathway":"GO_MICROVILLUS_ORGANIZATION","pval":0.87954,"padj":0.98007,"ES":0.53339,"NES":0.70418,"nMoreExtreme":54368,"size":20,"leadingEdge":["GLDN","RAPGEF2","PODXL"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TAU_PROTEIN_KINASE_ACTIVITY","pval":0.73618,"padj":0.95787,"ES":0.52648,"NES":0.704,"nMoreExtreme":39510,"size":6,"leadingEdge":["HSP90AA1","HSP90AB1","DKK1","EGR1","CLU"]} {"pathway":"GO_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION","pval":0.96492,"padj":0.99537,"ES":0.44878,"NES":0.70382,"nMoreExtreme":70662,"size":64,"leadingEdge":["FAM107A","S100A10","SRC","GPM6B","SMAD3"]} {"pathway":"GO_MELANIN_BIOSYNTHETIC_PROCESS","pval":0.86732,"padj":0.97662,"ES":0.5505,"NES":0.70334,"nMoreExtreme":51538,"size":15,"leadingEdge":["RAPGEF2","CTNS","CDH3"]} {"pathway":"GO_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY","pval":0.87591,"padj":0.979,"ES":0.53999,"NES":0.70327,"nMoreExtreme":53291,"size":18,"leadingEdge":["ZFP36","BTG2","PABPC1"]} {"pathway":"GO_REGULATION_OF_ADIPOSE_TISSUE_DEVELOPMENT","pval":0.73689,"padj":0.95787,"ES":0.52503,"NES":0.70206,"nMoreExtreme":39548,"size":6,"leadingEdge":["PLAAT3","SIRT1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SYNAPTIC_VESICLE_EXOCYTOSIS","pval":0.69556,"padj":0.94995,"ES":0.51025,"NES":0.70189,"nMoreExtreme":36804,"size":5,"leadingEdge":["FMR1","RAP1A","RAP1B","SYT4","BRAF"]} {"pathway":"GO_MATING","pval":0.88412,"padj":0.98086,"ES":0.52797,"NES":0.70188,"nMoreExtreme":55024,"size":21,"leadingEdge":["NCOA1","MAPK8IP2","HDAC4","HEXB"]} {"pathway":"GO_DENDRITIC_SPINE_MORPHOGENESIS","pval":0.95155,"padj":0.99278,"ES":0.4593,"NES":0.70139,"nMoreExtreme":67365,"size":52,"leadingEdge":["LRRK2","SRCIN1","ARC","ARHGAP33"]} {"pathway":"GO_POSITIVE_REGULATION_OF_REGULATED_SECRETORY_PATHWAY","pval":0.93524,"padj":0.98762,"ES":0.4717,"NES":0.70109,"nMoreExtreme":64398,"size":43,"leadingEdge":["HLA-F","PTAFR","CACNA1I","FCER1G","FGR"]} {"pathway":"GO_SNORNA_LOCALIZATION","pval":0.69598,"padj":0.94995,"ES":0.50957,"NES":0.70095,"nMoreExtreme":36826,"size":5,"leadingEdge":["NOP58","PIH1D1","FBL","ZNHIT6"]} {"pathway":"GO_BRANCHING_INVOLVED_IN_PROSTATE_GLAND_MORPHOGENESIS","pval":0.81959,"padj":0.97144,"ES":0.5487,"NES":0.70086,"nMoreExtreme":45801,"size":9,"leadingEdge":["NKX3-1","FGFR2"]} {"pathway":"GO_ACYLGLYCEROL_HOMEOSTASIS","pval":0.88536,"padj":0.98086,"ES":0.52704,"NES":0.70063,"nMoreExtreme":55101,"size":21,"leadingEdge":["DGAT2","NR1H3","ANGPTL4","MLXIPL"]} {"pathway":"GO_STEROL_HOMEOSTASIS","pval":0.9585,"padj":0.9934,"ES":0.45418,"NES":0.70018,"nMoreExtreme":68572,"size":56,"leadingEdge":["SOAT1","GRAMD1B","TTC39B","DGAT2","LIPG","NR1H3","NPC1","FABP4","NR5A2","EHD1"]} {"pathway":"GO_VENOUS_BLOOD_VESSEL_MORPHOGENESIS","pval":0.82015,"padj":0.97171,"ES":0.54785,"NES":0.69977,"nMoreExtreme":45832,"size":9,"leadingEdge":["HEG1","PROX1","VEGFA"]} {"pathway":"GO_REGULATION_OF_PRESYNAPTIC_MEMBRANE_POTENTIAL","pval":0.72947,"padj":0.95596,"ES":0.46911,"NES":0.6997,"nMoreExtreme":36657,"size":2,"leadingEdge":["KCNA1","GRIK2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_SYNAPSE","pval":0.80053,"padj":0.96646,"ES":0.54187,"NES":0.6994,"nMoreExtreme":44109,"size":8,"leadingEdge":["CLSTN3","TYROBP"]} {"pathway":"GO_GLANDULAR_EPITHELIAL_CELL_DEVELOPMENT","pval":0.8842,"padj":0.98086,"ES":0.52964,"NES":0.69923,"nMoreExtreme":54656,"size":20,"leadingEdge":["SIDT2","BAD"]} {"pathway":"GO_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION","pval":0.92377,"padj":0.987,"ES":0.4846,"NES":0.69798,"nMoreExtreme":61570,"size":35,"leadingEdge":["AGT","IL6","TGFB1","HAS2","CFLAR","SMAD3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_KIDNEY_DEVELOPMENT","pval":0.83627,"padj":0.97458,"ES":0.54977,"NES":0.69795,"nMoreExtreme":47203,"size":10,"leadingEdge":["STAT1","GATA3","HNF1B"]} {"pathway":"GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DIFFERENTIATION","pval":0.98589,"padj":0.99994,"ES":0.43405,"NES":0.69788,"nMoreExtreme":74643,"size":79,"leadingEdge":["IL31RA","SIDT2","ASCL1","CDKN1A","PDZD7","PROX1"]} {"pathway":"GO_DOPAMINERGIC_NEURON_DIFFERENTIATION","pval":0.89779,"padj":0.98354,"ES":0.51444,"NES":0.69771,"nMoreExtreme":56858,"size":24,"leadingEdge":["NR4A2","WNT1","VEGFD"]} {"pathway":"GO_VENOUS_BLOOD_VESSEL_DEVELOPMENT","pval":0.86793,"padj":0.97662,"ES":0.54782,"NES":0.69716,"nMoreExtreme":51086,"size":14,"leadingEdge":["HEG1","PROX1","SEMA3C"]} {"pathway":"GO_REGULATION_OF_MACROPHAGE_MIGRATION","pval":0.90792,"padj":0.98435,"ES":0.50149,"NES":0.69692,"nMoreExtreme":58649,"size":28,"leadingEdge":["P2RX4","STAP1","SLAMF8","CCL5","CSF1","P2RY12","CCL3"]} {"pathway":"GO_AMINO_SUGAR_METABOLIC_PROCESS","pval":0.89003,"padj":0.98144,"ES":0.52407,"NES":0.6967,"nMoreExtreme":55392,"size":21,"leadingEdge":["NAGK","CHST2","PGM3"]} {"pathway":"GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_HYDROGEN_PEROXIDE","pval":0.69796,"padj":0.94995,"ES":0.5061,"NES":0.69617,"nMoreExtreme":36931,"size":5,"leadingEdge":["PDCD10","STK25","PARK7","TRAP1","PINK1"]} {"pathway":"GO_REGULATION_OF_CELL_ADHESION_MEDIATED_BY_INTEGRIN","pval":0.93525,"padj":0.98762,"ES":0.4733,"NES":0.69606,"nMoreExtreme":63750,"size":40,"leadingEdge":["MUC1","CCL5","LYN","P2RY12","PODXL"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT","pval":0.885,"padj":0.98086,"ES":0.53049,"NES":0.69562,"nMoreExtreme":54354,"size":19,"leadingEdge":["TGFB1","GAS6","CCL3","CCR1","ROCK1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_CORTEX","pval":0.69834,"padj":0.94995,"ES":0.50553,"NES":0.6954,"nMoreExtreme":36951,"size":5,"leadingEdge":["EPB41L2","GPSM2","GNAI1","NUMA1","EPB41"]} {"pathway":"GO_TELOMERE_TETHERING_AT_NUCLEAR_PERIPHERY","pval":0.73399,"padj":0.95787,"ES":0.46602,"NES":0.6951,"nMoreExtreme":36884,"size":2,"leadingEdge":["NUP98","SUN1"]} {"pathway":"GO_REGULATION_OF_CARDIAC_VASCULAR_SMOOTH_MUSCLE_CELL_DIFFERENTIATION","pval":0.73426,"padj":0.95787,"ES":0.46585,"NES":0.69484,"nMoreExtreme":36898,"size":2,"leadingEdge":["MYOCD","GPER1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CARDIAC_VASCULAR_SMOOTH_MUSCLE_CELL_DIFFERENTIATION","pval":0.73426,"padj":0.95787,"ES":0.46585,"NES":0.69484,"nMoreExtreme":36898,"size":2,"leadingEdge":["MYOCD","GPER1"]} {"pathway":"GO_GLYCOSYLCERAMIDE_BIOSYNTHETIC_PROCESS","pval":0.66553,"padj":0.94905,"ES":0.48775,"NES":0.69458,"nMoreExtreme":34637,"size":4,"leadingEdge":["PRKAA1","UGCG","B4GALT3","B3GALT2"]} {"pathway":"GO_ENTEROENDOCRINE_CELL_DIFFERENTIATION","pval":0.88622,"padj":0.98086,"ES":0.52964,"NES":0.6945,"nMoreExtreme":54429,"size":19,"leadingEdge":["SIDT2","BAD"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION","pval":0.88632,"padj":0.98086,"ES":0.5296,"NES":0.69445,"nMoreExtreme":54435,"size":19,"leadingEdge":["BCL6","RIPOR2","HEG1","MET","ITGA3"]} {"pathway":"GO_BONE_MORPHOGENESIS","pval":0.99411,"padj":1,"ES":0.42738,"NES":0.69408,"nMoreExtreme":76393,"size":87,"leadingEdge":["COMP","TIFAB","SMPD3","TGFB1","HAS2","FOXC1","INSIG2","COCH","NEUROG1","COL27A1"]} {"pathway":"GO_SPERM_CHROMATIN_CONDENSATION","pval":0.66583,"padj":0.94905,"ES":0.48716,"NES":0.69374,"nMoreExtreme":34653,"size":4,"leadingEdge":["PSME4","SRPK1","RNF8"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TRANSMEMBRANE_TRANSPORT","pval":0.99682,"padj":1,"ES":0.42416,"NES":0.69364,"nMoreExtreme":77431,"size":93,"leadingEdge":["CAMK2D","SRI","DYSF","KCNE5","RSC1A1","TNF","GEM","KCNE1","TGFB1","ACTN2","MIR212","CLIC2","KCNE1B"]} {"pathway":"GO_CRD_MEDIATED_MRNA_STABILIZATION","pval":0.69921,"padj":0.94995,"ES":0.50424,"NES":0.69362,"nMoreExtreme":36997,"size":5,"leadingEdge":["YBX1","SYNCRIP","DHX9","HNRNPU","IGF2BP1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION","pval":0.96052,"padj":0.9934,"ES":0.45518,"NES":0.69359,"nMoreExtreme":67856,"size":51,"leadingEdge":["HGF","IFITM1","IL6","IGF1"]} {"pathway":"GO_NEUTROPHIL_MEDIATED_KILLING_OF_GRAM_NEGATIVE_BACTERIUM","pval":0.66979,"padj":0.94905,"ES":0.47054,"NES":0.69324,"nMoreExtreme":34240,"size":3,"leadingEdge":["TUSC2","CXCL6","F2RL1"]} {"pathway":"GO_BONE_RESORPTION","pval":0.95163,"padj":0.99278,"ES":0.46139,"NES":0.69307,"nMoreExtreme":66236,"size":46,"leadingEdge":["P2RX7","SNX10","CD38","IL7","TNFAIP3","IL6","SRC","PPARGC1B"]} {"pathway":"GO_ANTERIOR_POSTERIOR_AXIS_SPECIFICATION","pval":0.926,"padj":0.987,"ES":0.48531,"NES":0.69244,"nMoreExtreme":61211,"size":33,"leadingEdge":["TIFAB","HOXD8","NEUROG1"]} {"pathway":"GO_MAINTENANCE_OF_PROTEIN_LOCATION_IN_MITOCHONDRION","pval":0.69966,"padj":0.94995,"ES":0.50334,"NES":0.69239,"nMoreExtreme":37021,"size":5,"leadingEdge":["TSPO","AKT1","HK1","PINK1","HK2"]} {"pathway":"GO_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_RESULTING_IN_TRANSCRIPTION","pval":0.8831,"padj":0.98086,"ES":0.53533,"NES":0.6923,"nMoreExtreme":53365,"size":17,"leadingEdge":["MUC1","PYHIN1","HIPK2"]} {"pathway":"GO_L_SERINE_CATABOLIC_PROCESS","pval":0.6997,"padj":0.94995,"ES":0.50327,"NES":0.69229,"nMoreExtreme":37023,"size":5,"leadingEdge":["SDSL","SDS"]} {"pathway":"GO_REGULATION_OF_PLASMINOGEN_ACTIVATION","pval":0.85117,"padj":0.97645,"ES":0.5464,"NES":0.69192,"nMoreExtreme":48601,"size":11,"leadingEdge":["CTSZ","HPN","PLGRKT","ENO1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION","pval":0.90676,"padj":0.98425,"ES":0.50688,"NES":0.69171,"nMoreExtreme":57763,"size":25,"leadingEdge":["VEGFC","NBN","SRC","PDGFB","MRE11"]} {"pathway":"GO_CONVERGENT_EXTENSION_INVOLVED_IN_GASTRULATION","pval":0.77682,"padj":0.96098,"ES":0.52859,"NES":0.69143,"nMoreExtreme":42224,"size":7,"leadingEdge":["DVL2","SFRP1","DVL1","NPHP3","WNT5A","MKKS"]} {"pathway":"GO_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS","pval":0.99118,"padj":1,"ES":0.43059,"NES":0.69122,"nMoreExtreme":74869,"size":78,"leadingEdge":["B2M","C3","CCL19","ANKRD13A","FLOT1","ARC"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_ARREST","pval":0.89352,"padj":0.98267,"ES":0.52349,"NES":0.69112,"nMoreExtreme":55232,"size":20,"leadingEdge":["FGF10","MLXIPL"]} {"pathway":"GO_METANEPHRIC_GLOMERULUS_DEVELOPMENT","pval":0.86126,"padj":0.97645,"ES":0.54523,"NES":0.69043,"nMoreExtreme":49679,"size":12,"leadingEdge":["PDGFRA","PDGFB","PDGFRB"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELL_MATURATION","pval":0.70076,"padj":0.94995,"ES":0.50154,"NES":0.68991,"nMoreExtreme":37079,"size":5,"leadingEdge":["GAL","BCL11A","EDNRB","TBX6","NPR2"]} {"pathway":"GO_PYRIMIDINE_CONTAINING_COMPOUND_SALVAGE","pval":0.8411,"padj":0.97458,"ES":0.54305,"NES":0.68942,"nMoreExtreme":47476,"size":10,"leadingEdge":["TYMP","HDDC2"]} {"pathway":"GO_MESENCHYME_MIGRATION","pval":0.66808,"padj":0.94905,"ES":0.48399,"NES":0.68922,"nMoreExtreme":34770,"size":4,"leadingEdge":["FOXF1","ACTA2","ACTC1","ACTG2"]} {"pathway":"GO_ICOSANOID_METABOLIC_PROCESS","pval":0.96054,"padj":0.9934,"ES":0.45607,"NES":0.68915,"nMoreExtreme":67251,"size":48,"leadingEdge":["CYP1A1","GGT5","PLA2G4C","CBR1","PLA2G4A","PTGS2"]} {"pathway":"GO_CELLULAR_CARBOHYDRATE_CATABOLIC_PROCESS","pval":0.94223,"padj":0.98878,"ES":0.47022,"NES":0.6891,"nMoreExtreme":63998,"size":39,"leadingEdge":["GK","GPD2","STBD1"]} {"pathway":"GO_DEPHOSPHORYLATION_OF_RNA_POLYMERASE_II_C_TERMINAL_DOMAIN","pval":0.70125,"padj":0.94995,"ES":0.50076,"NES":0.68883,"nMoreExtreme":37105,"size":5,"leadingEdge":["CTDP1","RPRD1B","RPAP2","RPRD1A","SSU72"]} {"pathway":"GO_FOLLICLE_STIMULATING_HORMONE_SECRETION","pval":0.66866,"padj":0.94905,"ES":0.48354,"NES":0.68858,"nMoreExtreme":34800,"size":4,"leadingEdge":["INHBA","TBX3","SMAD4","INHBB"]} {"pathway":"GO_POSITIVE_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT","pval":0.94117,"padj":0.98829,"ES":0.47181,"NES":0.6884,"nMoreExtreme":63639,"size":38,"leadingEdge":["C21orf91","LPAR1","PAFAH1B1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION","pval":0.9559,"padj":0.9934,"ES":0.45967,"NES":0.68821,"nMoreExtreme":66364,"size":45,"leadingEdge":["GLIPR2","IL6","TGFB1","FOXC1","SMAD3","WWTR1"]} {"pathway":"GO_PYRIMIDINE_NUCLEOSIDE_BIOSYNTHETIC_PROCESS","pval":0.8703,"padj":0.97692,"ES":0.54305,"NES":0.68813,"nMoreExtreme":50686,"size":13,"leadingEdge":["TYMP","CAD"]} {"pathway":"GO_ACTIVATION_OF_PROTEIN_KINASE_B_ACTIVITY","pval":0.91837,"padj":0.987,"ES":0.49491,"NES":0.68778,"nMoreExtreme":59324,"size":28,"leadingEdge":["TXN","SRC","GAS6","PDGFB","IGF1"]} {"pathway":"GO_MORPHOGENESIS_OF_AN_EPITHELIAL_FOLD","pval":0.88704,"padj":0.98086,"ES":0.53178,"NES":0.68772,"nMoreExtreme":53603,"size":17,"leadingEdge":["FGF10","FGFR2"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_ALDEHYDE","pval":0.74179,"padj":0.95912,"ES":0.51427,"NES":0.68767,"nMoreExtreme":39811,"size":6,"leadingEdge":["RDH11","AKR1B1","PARK7","AKR1A1","RDH12","AIFM1"]} {"pathway":"GO_FACIAL_NERVE_MORPHOGENESIS","pval":0.84213,"padj":0.97458,"ES":0.54139,"NES":0.68732,"nMoreExtreme":47534,"size":10,"leadingEdge":["EGR2","SEMA3F","SIX1"]} {"pathway":"GO_SMAD_PROTEIN_COMPLEX_ASSEMBLY","pval":0.87074,"padj":0.97709,"ES":0.54233,"NES":0.68723,"nMoreExtreme":50712,"size":13,"leadingEdge":["TGFB1","SMAD3","EID2"]} {"pathway":"GO_PROTEIN_DEMANNOSYLATION","pval":0.89431,"padj":0.98309,"ES":0.52399,"NES":0.6871,"nMoreExtreme":54926,"size":19,"leadingEdge":["EDEM1","EDEM2"]} {"pathway":"GO_L_ARGININE_TRANSPORT","pval":0.74198,"padj":0.95912,"ES":0.51381,"NES":0.68705,"nMoreExtreme":39821,"size":6,"leadingEdge":["AGT","SLC7A2"]} {"pathway":"GO_REGULATION_OF_METALLOENDOPEPTIDASE_ACTIVITY","pval":0.74233,"padj":0.95912,"ES":0.51314,"NES":0.68615,"nMoreExtreme":39840,"size":6,"leadingEdge":["STAT3","PICALM"]} {"pathway":"GO_REGULATION_OF_CELL_GROWTH_INVOLVED_IN_CARDIAC_MUSCLE_CELL_DEVELOPMENT","pval":0.8846,"padj":0.98086,"ES":0.5341,"NES":0.68613,"nMoreExtreme":52989,"size":16,"leadingEdge":["EDN1","PAK1","IGF1"]} {"pathway":"GO_REGULATION_OF_FC_GAMMA_RECEPTOR_SIGNALING_PATHWAY_INVOLVED_IN_PHAGOCYTOSIS","pval":0.7789,"padj":0.96098,"ES":0.5244,"NES":0.68596,"nMoreExtreme":42337,"size":7,"leadingEdge":["CD47","PTPRC","RAPGEF1"]} {"pathway":"GO_PEPTIDE_CROSS_LINKING","pval":0.89653,"padj":0.98354,"ES":0.52252,"NES":0.68517,"nMoreExtreme":55062,"size":19,"leadingEdge":["TGM2","DCN"]} {"pathway":"GO_ENDOCRINE_HORMONE_SECRETION","pval":0.92649,"padj":0.987,"ES":0.48777,"NES":0.68507,"nMoreExtreme":60397,"size":30,"leadingEdge":["HCAR2","AGT","GATA3","NKX3-1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_HEART_GROWTH","pval":0.93966,"padj":0.98783,"ES":0.47563,"NES":0.68506,"nMoreExtreme":62629,"size":35,"leadingEdge":["PIM1","EDN1","PROX1"]} {"pathway":"GO_REGULATION_OF_ERAD_PATHWAY","pval":0.92437,"padj":0.987,"ES":0.49028,"NES":0.68497,"nMoreExtreme":59985,"size":29,"leadingEdge":["EDEM1","NFE2L2","HERPUD1","EDEM2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CHROMATIN_BINDING","pval":0.865,"padj":0.97662,"ES":0.54087,"NES":0.68492,"nMoreExtreme":49895,"size":12,"leadingEdge":["DTX3L","PARP9","KDM1A"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH","pval":0.90872,"padj":0.98471,"ES":0.50767,"NES":0.68413,"nMoreExtreme":57174,"size":23,"leadingEdge":["SPTBN4","CSF1","GPR21"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_NOREPINEPHRINE_SECRETION","pval":0.67121,"padj":0.94905,"ES":0.48037,"NES":0.68407,"nMoreExtreme":34933,"size":4,"leadingEdge":["P2RY12","ADRA2A"]} {"pathway":"GO_MODIFIED_AMINO_ACID_TRANSPORT","pval":0.89126,"padj":0.98195,"ES":0.52861,"NES":0.68361,"nMoreExtreme":53858,"size":17,"leadingEdge":["CTNS","SLC22A16"]} {"pathway":"GO_MOTOR_NEURON_AXON_GUIDANCE","pval":0.89793,"padj":0.98354,"ES":0.52132,"NES":0.6836,"nMoreExtreme":55148,"size":19,"leadingEdge":["EGR2","SLIT2","SEMA3F","MYCBP2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION","pval":0.90692,"padj":0.98429,"ES":0.5105,"NES":0.68346,"nMoreExtreme":56747,"size":22,"leadingEdge":["HPN","FUZ"]} {"pathway":"GO_REGULATION_OF_NK_T_CELL_DIFFERENTIATION","pval":0.67179,"padj":0.94905,"ES":0.47972,"NES":0.68314,"nMoreExtreme":34963,"size":4,"leadingEdge":["PRDM1","AP3D1","AP3B1","TGFBR2"]} {"pathway":"GO_MALE_GENITALIA_DEVELOPMENT","pval":0.87356,"padj":0.97786,"ES":0.53897,"NES":0.68297,"nMoreExtreme":50876,"size":13,"leadingEdge":["FGF10","PDGFRA","SYCP2"]} {"pathway":"GO_TRNA_CATABOLIC_PROCESS","pval":0.77982,"padj":0.96116,"ES":0.52205,"NES":0.68288,"nMoreExtreme":42387,"size":7,"leadingEdge":["EXOSC7","POP1","EXOSC3","EXOSC8","EXOSC9","EXOSC2","SLFN13"]} {"pathway":"GO_POSITIVE_REGULATION_OF_METANEPHRIC_GLOMERULUS_DEVELOPMENT","pval":0.74642,"padj":0.96025,"ES":0.45748,"NES":0.68236,"nMoreExtreme":37509,"size":2,"leadingEdge":["EGR1","RET"]} {"pathway":"GO_DISACCHARIDE_BIOSYNTHETIC_PROCESS","pval":0.681,"padj":0.94976,"ES":0.46296,"NES":0.68207,"nMoreExtreme":34813,"size":3,"leadingEdge":["B4GALT1","SLC2A1","FBP1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CALCINEURIN_MEDIATED_SIGNALING","pval":0.88476,"padj":0.98086,"ES":0.53346,"NES":0.68157,"nMoreExtreme":52574,"size":15,"leadingEdge":["TNF","PTBP1"]} {"pathway":"GO_UTERUS_DEVELOPMENT","pval":0.89996,"padj":0.98417,"ES":0.51975,"NES":0.68154,"nMoreExtreme":55273,"size":19,"leadingEdge":["SRC","CDKN1C","GATA3","HOXA11"]} {"pathway":"GO_REGULATION_OF_CELL_COMMUNICATION_BY_ELECTRICAL_COUPLING","pval":0.84537,"padj":0.97458,"ES":0.53647,"NES":0.68107,"nMoreExtreme":47717,"size":10,"leadingEdge":["CAMK2D","SRI","SLC8A1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CATION_CHANNEL_ACTIVITY","pval":0.97177,"padj":0.99724,"ES":0.44945,"NES":0.681,"nMoreExtreme":68187,"size":49,"leadingEdge":["CTSS","ANK2","RNF207","STAC3","ACTN2","RGS9","S100A1","ARC","HAP1"]} {"pathway":"GO_REGULATION_OF_CELL_AGING","pval":0.95955,"padj":0.9934,"ES":0.45968,"NES":0.68076,"nMoreExtreme":65799,"size":42,"leadingEdge":["HLA-G","BCL6","CGAS","NAMPT","ZNF277","WNT1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TRANSLATION_IN_RESPONSE_TO_STRESS","pval":0.74418,"padj":0.95959,"ES":0.50904,"NES":0.68068,"nMoreExtreme":39939,"size":6,"leadingEdge":["NCK2","PPP1R15A","DNAJC3","EIF2AK4","IMPACT","NCK1"]} {"pathway":"GO_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION","pval":0.99104,"padj":1,"ES":0.43221,"NES":0.68058,"nMoreExtreme":72914,"size":66,"leadingEdge":["RTP4","HPN","CXCL12","PDZD7","OR2A5","PKD2L1"]} {"pathway":"GO_TYPE_B_PANCREATIC_CELL_DEVELOPMENT","pval":0.88954,"padj":0.98138,"ES":0.52964,"NES":0.68041,"nMoreExtreme":53285,"size":16,"leadingEdge":["SIDT2","BAD"]} {"pathway":"GO_VITAMIN_TRANSPORT","pval":0.91071,"padj":0.98532,"ES":0.50793,"NES":0.68002,"nMoreExtreme":56984,"size":22,"leadingEdge":["TCN2","AMN","SCARB1"]} {"pathway":"GO_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS","pval":0.97674,"padj":0.99889,"ES":0.44522,"NES":0.67989,"nMoreExtreme":69148,"size":52,"leadingEdge":["SIDT2","SRI","UCP2","NADK","PIM3","BAD"]} {"pathway":"GO_REGULATION_OF_POSTSYNAPSE_ORGANIZATION","pval":0.9991,"padj":1,"ES":0.41998,"NES":0.67955,"nMoreExtreme":76336,"size":84,"leadingEdge":["LRRK2","NRCAM","SRCIN1","SHISA7","ARC","RAPSN","PTN","SEMA3F","LILRB2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_DNA_LIGATION","pval":0.70548,"padj":0.9508,"ES":0.49336,"NES":0.67866,"nMoreExtreme":37329,"size":5,"leadingEdge":["PARP3","APLF"]} {"pathway":"GO_5_PHOSPHORIBOSE_1_DIPHOSPHATE_BIOSYNTHETIC_PROCESS","pval":0.70548,"padj":0.9508,"ES":0.49334,"NES":0.67863,"nMoreExtreme":37329,"size":5,"leadingEdge":["PYGL","PRPS2","PRPSAP2","PRPS1","PRPSAP1"]} {"pathway":"GO_REGULATION_OF_ENDOCRINE_PROCESS","pval":0.92748,"padj":0.987,"ES":0.49071,"NES":0.67781,"nMoreExtreme":59636,"size":27,"leadingEdge":["HCAR2","AGT","NKX3-1"]} {"pathway":"GO_PODOSOME_ASSEMBLY","pval":0.90043,"padj":0.98417,"ES":0.5202,"NES":0.67749,"nMoreExtreme":54783,"size":18,"leadingEdge":["TNF","FARP2","SRC","LCP1"]} {"pathway":"GO_OVULATION","pval":0.89763,"padj":0.98354,"ES":0.52345,"NES":0.67694,"nMoreExtreme":54243,"size":17,"leadingEdge":["TNFAIP6","PTGS2","EREG"]} {"pathway":"GO_REGULATION_OF_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER","pval":0.92007,"padj":0.987,"ES":0.49891,"NES":0.67665,"nMoreExtreme":58269,"size":24,"leadingEdge":["GTF2B","HNF1B","PSMC4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_RESPONSE_TO_DRUG","pval":0.90504,"padj":0.98417,"ES":0.516,"NES":0.67661,"nMoreExtreme":55585,"size":19,"leadingEdge":["AGT","CXCL12","ADORA2A"]} {"pathway":"GO_PARASYMPATHETIC_NERVOUS_SYSTEM_DEVELOPMENT","pval":0.88881,"padj":0.98088,"ES":0.52937,"NES":0.67635,"nMoreExtreme":52815,"size":15,"leadingEdge":["EGR2","TBX1","SEMA3F","SIX1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE","pval":0.87835,"padj":0.97973,"ES":0.53351,"NES":0.67605,"nMoreExtreme":51155,"size":13,"leadingEdge":["BCL2L11","PTPN2","PTPN1","BAK1"]} {"pathway":"GO_MACROPHAGE_FUSION","pval":0.70654,"padj":0.9508,"ES":0.49139,"NES":0.67594,"nMoreExtreme":37385,"size":5,"leadingEdge":["OCSTAMP","DCSTAMP","TYROBP"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT","pval":0.96357,"padj":0.995,"ES":0.45797,"NES":0.67575,"nMoreExtreme":65854,"size":41,"leadingEdge":["PIM1","EDN1","TGFB1","IGF1"]} {"pathway":"GO_REGULATION_OF_STEM_CELL_PROLIFERATION","pval":0.97269,"padj":0.99756,"ES":0.45053,"NES":0.67453,"nMoreExtreme":67530,"size":45,"leadingEdge":["LRRK2","OVOL1","VEGFC","PTPRC","TGFB1","CX3CL1"]} {"pathway":"GO_FACE_MORPHOGENESIS","pval":0.93704,"padj":0.98783,"ES":0.48242,"NES":0.67399,"nMoreExtreme":60807,"size":29,"leadingEdge":["TGFB1","CRISPLD1","PDGFRA","CRISPLD2","ARID5B","TBX1"]} {"pathway":"GO_TRANSCRIPTION_DEPENDENT_TETHERING_OF_RNA_POLYMERASE_II_GENE_DNA_AT_NUCLEAR_PERIPHERY","pval":0.7471,"padj":0.96029,"ES":0.50272,"NES":0.67222,"nMoreExtreme":40096,"size":6,"leadingEdge":["RAE1","NUP98","NUP107","NUP155","PCID2"]} {"pathway":"GO_PHOSPHOLIPASE_C_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY","pval":0.99027,"padj":1,"ES":0.43492,"NES":0.6722,"nMoreExtreme":71047,"size":57,"leadingEdge":["AGT","TGM2","EDN1","GPR18","F2RL2","FPR2","P2RY12","P2RY2","ACTN2","LPAR1"]} {"pathway":"GO_ARGININE_TRANSPORT","pval":0.78376,"padj":0.96311,"ES":0.5138,"NES":0.67209,"nMoreExtreme":42601,"size":7,"leadingEdge":["AGT","SLC7A2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_BMP_SIGNALING_PATHWAY","pval":0.96113,"padj":0.9934,"ES":0.46062,"NES":0.67208,"nMoreExtreme":64989,"size":38,"leadingEdge":["CHRD","WNT1"]} {"pathway":"GO_PROTEIN_SIDE_CHAIN_DEGLUTAMYLATION","pval":0.69137,"padj":0.94995,"ES":0.45605,"NES":0.67189,"nMoreExtreme":35343,"size":3,"leadingEdge":["AGTPBP1","AGBL3","AGBL2"]} {"pathway":"GO_SYNAPTONEMAL_COMPLEX_ORGANIZATION","pval":0.88733,"padj":0.98086,"ES":0.52788,"NES":0.67177,"nMoreExtreme":52228,"size":14,"leadingEdge":["HORMAD1","STAG3","SYCP2"]} {"pathway":"GO_UTERUS_MORPHOGENESIS","pval":0.68024,"padj":0.94976,"ES":0.47107,"NES":0.67082,"nMoreExtreme":35403,"size":4,"leadingEdge":["ASH1L","KDM5B","STRA6","NIPBL"]} {"pathway":"GO_NEUTRAL_AMINO_ACID_TRANSPORT","pval":0.9298,"padj":0.98762,"ES":0.49152,"NES":0.67074,"nMoreExtreme":59231,"size":25,"leadingEdge":["CTNS","NFKBIE","SLC38A5"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SPROUTING_ANGIOGENESIS","pval":0.93019,"padj":0.98762,"ES":0.49135,"NES":0.67052,"nMoreExtreme":59256,"size":25,"leadingEdge":["KLF4","MIR503","TBXA2R"]} {"pathway":"GO_HYDROGEN_PEROXIDE_CATABOLIC_PROCESS","pval":0.8744,"padj":0.97837,"ES":0.52942,"NES":0.67042,"nMoreExtreme":50437,"size":12,"leadingEdge":["PRDX1","NNT"]} {"pathway":"GO_PEPTIDE_HORMONE_PROCESSING","pval":0.91725,"padj":0.987,"ES":0.5043,"NES":0.67041,"nMoreExtreme":57086,"size":21,"leadingEdge":["CTSZ","CES1","NGF","ENPEP"]} {"pathway":"GO_SODIUM_INDEPENDENT_ORGANIC_ANION_TRANSPORT","pval":0.78466,"padj":0.96311,"ES":0.51216,"NES":0.66994,"nMoreExtreme":42650,"size":7,"leadingEdge":["SLCO4A1","MFSD10"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT","pval":0.94217,"padj":0.98878,"ES":0.47932,"NES":0.66966,"nMoreExtreme":61140,"size":29,"leadingEdge":["P2RX7","DTNBP1","KMO","ADORA2A"]} {"pathway":"GO_MIDBODY_ABSCISSION","pval":0.90425,"padj":0.98417,"ES":0.51754,"NES":0.6693,"nMoreExtreme":54643,"size":17,"leadingEdge":["CHMP4C","MITD1","CHMP2B"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_FISSION","pval":0.88932,"padj":0.98128,"ES":0.52586,"NES":0.6692,"nMoreExtreme":52345,"size":14,"leadingEdge":["DDHD1","DCN"]} {"pathway":"GO_MATING_BEHAVIOR","pval":0.88378,"padj":0.98086,"ES":0.52801,"NES":0.66909,"nMoreExtreme":51471,"size":13,"leadingEdge":["NCOA1","MAPK8IP2","HDAC4","HEXB"]} {"pathway":"GO_CATECHOLAMINE_METABOLIC_PROCESS","pval":0.92863,"padj":0.98741,"ES":0.49323,"NES":0.66894,"nMoreExtreme":58811,"size":24,"leadingEdge":["NPR1","NR4A2","SNCAIP"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CATION_CHANNEL_ACTIVITY","pval":0.95699,"padj":0.9934,"ES":0.46649,"NES":0.66877,"nMoreExtreme":63530,"size":34,"leadingEdge":["SRI","DYSF","KCNE5","GEM","KCNE1","MIR212","CLIC2","KCNE1B","GPR35"]} {"pathway":"GO_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION","pval":0.97821,"padj":0.99901,"ES":0.44662,"NES":0.66867,"nMoreExtreme":67913,"size":45,"leadingEdge":["VEGFC","MVP","PTPRC","NBN","SRC","PDGFB"]} {"pathway":"GO_PLASMA_MEMBRANE_TUBULATION","pval":0.91915,"padj":0.987,"ES":0.50282,"NES":0.66845,"nMoreExtreme":57204,"size":21,"leadingEdge":["FCHO1","EHD2"]} {"pathway":"GO_MESODERMAL_CELL_MIGRATION","pval":0.75926,"padj":0.96032,"ES":0.44805,"NES":0.66829,"nMoreExtreme":38154,"size":2,"leadingEdge":["EPB41L5","MESP1"]} {"pathway":"GO_REGULATION_OF_CYTOPLASMIC_TRANSLATION","pval":0.93327,"padj":0.98762,"ES":0.48936,"NES":0.6678,"nMoreExtreme":59452,"size":25,"leadingEdge":["LIN28A","YBX3"]} {"pathway":"GO_L_SERINE_TRANSPORT","pval":0.68238,"padj":0.94976,"ES":0.46894,"NES":0.66778,"nMoreExtreme":35514,"size":4,"leadingEdge":["SLC38A7","SLC1A5","SLC1A4","SFXN1"]} {"pathway":"GO_CELL_DIFFERENTIATION_INVOLVED_IN_EMBRYONIC_PLACENTA_DEVELOPMENT","pval":0.92127,"padj":0.987,"ES":0.50154,"NES":0.66675,"nMoreExtreme":57336,"size":21,"leadingEdge":["ASCL2","SOCS3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_PROLIFERATION","pval":0.92738,"padj":0.987,"ES":0.49477,"NES":0.66674,"nMoreExtreme":58348,"size":23,"leadingEdge":["PIM1","FGFR2"]} {"pathway":"GO_CENTRAL_NERVOUS_SYSTEM_PROJECTION_NEURON_AXONOGENESIS","pval":0.92436,"padj":0.987,"ES":0.49784,"NES":0.66652,"nMoreExtreme":57838,"size":22,"leadingEdge":["SPTBN4","NR4A2","SLIT2","MYCBP2"]} {"pathway":"GO_GASTRIC_ACID_SECRETION","pval":0.86708,"padj":0.97662,"ES":0.52559,"NES":0.66556,"nMoreExtreme":49509,"size":11,"leadingEdge":["SNX10","SLC9A4"]} {"pathway":"GO_GROWTH_PLATE_CARTILAGE_MORPHOGENESIS","pval":0.88692,"padj":0.98086,"ES":0.5246,"NES":0.66476,"nMoreExtreme":51654,"size":13,"leadingEdge":["COCH","COL12A1"]} {"pathway":"GO_HEME_TRANSPORT","pval":0.78661,"padj":0.96311,"ES":0.50806,"NES":0.66458,"nMoreExtreme":42756,"size":7,"leadingEdge":["FLVCR2","CUBN"]} {"pathway":"GO_FOREBRAIN_CELL_MIGRATION","pval":0.98663,"padj":0.99994,"ES":0.43957,"NES":0.66421,"nMoreExtreme":69078,"size":48,"leadingEdge":["LRRK2","CXCL12","P2RY12","ROBO1","SLIT2"]} {"pathway":"GO_GLUCOSAMINE_CONTAINING_COMPOUND_METABOLIC_PROCESS","pval":0.8873,"padj":0.98086,"ES":0.5241,"NES":0.66413,"nMoreExtreme":51676,"size":13,"leadingEdge":["NAGK","CHST2","PGM3"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_ESTROGEN_STIMULUS","pval":0.89326,"padj":0.98267,"ES":0.52187,"NES":0.66413,"nMoreExtreme":52577,"size":14,"leadingEdge":["SERPINB9","OCSTAMP","ARID5A","ESR1"]} {"pathway":"GO_REGULATION_OF_TRANSLATIONAL_TERMINATION","pval":0.81565,"padj":0.971,"ES":0.5144,"NES":0.66394,"nMoreExtreme":44942,"size":8,"leadingEdge":["UPF1","JMJD4","OGFOD1","GLE1","MTRF1","ETF1","EIF5A"]} {"pathway":"GO_REGULATION_OF_NEURON_MIGRATION","pval":0.96266,"padj":0.99463,"ES":0.46296,"NES":0.6637,"nMoreExtreme":63906,"size":34,"leadingEdge":["RAPGEF2","STAT3","CX3CL1","CAMK2B"]} {"pathway":"GO_N_ACETYLGLUCOSAMINE_METABOLIC_PROCESS","pval":0.86821,"padj":0.97662,"ES":0.52411,"NES":0.66369,"nMoreExtreme":49574,"size":11,"leadingEdge":["NAGK","CHST2","RENBP"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CYCLIC_NUCLEOTIDE_PHOSPHODIESTERASE_ACTIVITY","pval":0.70019,"padj":0.94995,"ES":0.45037,"NES":0.66353,"nMoreExtreme":35794,"size":3,"leadingEdge":["AIP","EGLN1","MAPK7"]} {"pathway":"GO_SMOOTH_MUSCLE_ADAPTATION","pval":0.68562,"padj":0.94976,"ES":0.46579,"NES":0.6633,"nMoreExtreme":35683,"size":4,"leadingEdge":["CYBA","HMOX1","IL1B","NOS3"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_PURINE_CONTAINING_COMPOUND","pval":0.81617,"padj":0.971,"ES":0.51349,"NES":0.66276,"nMoreExtreme":44971,"size":8,"leadingEdge":["SLC8A1","TMEM38B"]} {"pathway":"GO_POSITIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION","pval":0.98506,"padj":0.99994,"ES":0.44118,"NES":0.66271,"nMoreExtreme":68563,"size":46,"leadingEdge":["ZC3H12A","PTGS2","ZFP36","SNAI2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS","pval":0.7877,"padj":0.96334,"ES":0.50585,"NES":0.66169,"nMoreExtreme":42815,"size":7,"leadingEdge":["TIMP2","ROCK1","PTPN3","TIMP3","TIMP1"]} {"pathway":"GO_REGULATION_OF_OSTEOCLAST_DEVELOPMENT","pval":0.85556,"padj":0.97645,"ES":0.52117,"NES":0.66164,"nMoreExtreme":48292,"size":10,"leadingEdge":["NOTCH2","LILRB1","TYROBP"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION","pval":0.98622,"padj":0.99994,"ES":0.44029,"NES":0.66137,"nMoreExtreme":68644,"size":46,"leadingEdge":["CD74","CSF1","TNF","RUNX1","TGFB1","OCSTAMP","PPARGC1B","CCR1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_VIRAL_RELEASE_FROM_HOST_CELL","pval":0.90138,"padj":0.98417,"ES":0.51759,"NES":0.66129,"nMoreExtreme":53562,"size":15,"leadingEdge":["CHMP4C","TSG101"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE","pval":0.94714,"padj":0.99093,"ES":0.47789,"NES":0.66012,"nMoreExtreme":60900,"size":27,"leadingEdge":["GBP1","KCNE1","TGFB1","RHOQ"]} {"pathway":"GO_LUNG_LOBE_DEVELOPMENT","pval":0.71388,"padj":0.9532,"ES":0.47975,"NES":0.65993,"nMoreExtreme":37773,"size":5,"leadingEdge":["FGFR2","FOXF1","LIF","SEC24B","TGFBR2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PODOSOME_ASSEMBLY","pval":0.85648,"padj":0.97645,"ES":0.51977,"NES":0.65986,"nMoreExtreme":48344,"size":10,"leadingEdge":["TNF","SRC","LCP1"]} {"pathway":"GO_REGULATION_OF_DNA_LIGATION","pval":0.75156,"padj":0.9603,"ES":0.49336,"NES":0.65971,"nMoreExtreme":40335,"size":6,"leadingEdge":["PARP3","APLF"]} {"pathway":"GO_PROSTAGLANDIN_TRANSPORT","pval":0.89075,"padj":0.98183,"ES":0.52051,"NES":0.65958,"nMoreExtreme":51877,"size":13,"leadingEdge":["P2RX7","P2RX4","EDN1","NOS2"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_RETINOIC_ACID","pval":0.99316,"padj":1,"ES":0.43341,"NES":0.65841,"nMoreExtreme":69858,"size":50,"leadingEdge":["KLF4","LYN","RORB","ALDH1A2","TBX1","CYP26B1"]} {"pathway":"GO_HEPATIC_STELLATE_CELL_ACTIVATION","pval":0.75228,"padj":0.9603,"ES":0.49201,"NES":0.6579,"nMoreExtreme":40374,"size":6,"leadingEdge":["GCLC","GCLM"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_LYSOSOME","pval":0.96646,"padj":0.99537,"ES":0.46091,"NES":0.65763,"nMoreExtreme":63886,"size":33,"leadingEdge":["SNX16","NCOA4","GCC2","M6PR"]} {"pathway":"GO_REGULATION_OF_CELL_COMMUNICATION_BY_ELECTRICAL_COUPLING_INVOLVED_IN_CARDIAC_CONDUCTION","pval":0.81848,"padj":0.97133,"ES":0.50921,"NES":0.65725,"nMoreExtreme":45098,"size":8,"leadingEdge":["CAMK2D","SRI","CAV1"]} {"pathway":"GO_FATTY_ACID_DERIVATIVE_TRANSPORT","pval":0.94816,"padj":0.99095,"ES":0.47843,"NES":0.65685,"nMoreExtreme":60665,"size":26,"leadingEdge":["P2RX7","P2RX4","EDN1","PLA2G4A"]} {"pathway":"GO_MAGNESIUM_ION_HOMEOSTASIS","pval":0.81868,"padj":0.97133,"ES":0.50877,"NES":0.65667,"nMoreExtreme":45109,"size":8,"leadingEdge":["XK","TRPM7","KCNA1","SLC41A1","EGFR","CNNM2","ANK3","CNNM4"]} {"pathway":"GO_BASIC_AMINO_ACID_TRANSPORT","pval":0.84121,"padj":0.97458,"ES":0.5138,"NES":0.65627,"nMoreExtreme":47009,"size":9,"leadingEdge":["AGT","SLC7A2"]} {"pathway":"GO_CYCLIC_NUCLEOTIDE_BIOSYNTHETIC_PROCESS","pval":0.90588,"padj":0.98417,"ES":0.51354,"NES":0.65612,"nMoreExtreme":53829,"size":15,"leadingEdge":["NPR1","GUCY1A1","GUCY1B1","ADCY2"]} {"pathway":"GO_VESICLE_TETHERING","pval":0.7902,"padj":0.96472,"ES":0.50128,"NES":0.65571,"nMoreExtreme":42951,"size":7,"leadingEdge":["STARD3NL","TBC1D23","C17orf75","WDR11","EXOC4","STARD3"]} {"pathway":"GO_COMPLEMENT_RECEPTOR_MEDIATED_SIGNALING_PATHWAY","pval":0.8418,"padj":0.97458,"ES":0.51318,"NES":0.65548,"nMoreExtreme":47042,"size":9,"leadingEdge":["FPR2","GPLD1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS","pval":0.8193,"padj":0.97133,"ES":0.50762,"NES":0.6552,"nMoreExtreme":45143,"size":8,"leadingEdge":["DGAT2","ACADVL"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_FATTY_ACID_OXIDATION","pval":0.8193,"padj":0.97133,"ES":0.50762,"NES":0.6552,"nMoreExtreme":45143,"size":8,"leadingEdge":["DGAT2","ACADVL"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_GLYCOPROTEIN_BIOSYNTHETIC_PROCESS","pval":0.87354,"padj":0.97786,"ES":0.51738,"NES":0.65517,"nMoreExtreme":49878,"size":11,"leadingEdge":["JAK3","ABCA7"]} {"pathway":"GO_MITOTIC_CYTOKINETIC_PROCESS","pval":0.94075,"padj":0.98812,"ES":0.48555,"NES":0.65432,"nMoreExtreme":59189,"size":23,"leadingEdge":["CHMP4C","MITD1","RHOA"]} {"pathway":"GO_ANDROGEN_BIOSYNTHETIC_PROCESS","pval":0.75374,"padj":0.9603,"ES":0.48871,"NES":0.65349,"nMoreExtreme":40452,"size":6,"leadingEdge":["HSD17B6","SCARB1","MED1","SRD5A3","SRD5A1","WNT4"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_AMYLOID_BETA_CLEARANCE","pval":0.71707,"padj":0.95386,"ES":0.47464,"NES":0.6529,"nMoreExtreme":37942,"size":5,"leadingEdge":["CYP51A1","SRF","HMGCR","MYOCD","LRPAP1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY","pval":0.91384,"padj":0.98655,"ES":0.50815,"NES":0.6528,"nMoreExtreme":54741,"size":16,"leadingEdge":["SOD2","NFE2L2","SIRT1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MEIOTIC_CELL_CYCLE","pval":0.88636,"padj":0.98086,"ES":0.51521,"NES":0.65242,"nMoreExtreme":51127,"size":12,"leadingEdge":["OVOL1","HORMAD1","PRKAR1A"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS","pval":0.93943,"padj":0.98783,"ES":0.4873,"NES":0.6524,"nMoreExtreme":58781,"size":22,"leadingEdge":["DHX58","IL2RA","MICB","TSPAN6"]} {"pathway":"GO_FIBRINOLYSIS","pval":0.90343,"padj":0.98417,"ES":0.51189,"NES":0.65143,"nMoreExtreme":53176,"size":14,"leadingEdge":["SERPING1","GP1BA","PLAUR"]} {"pathway":"GO_CORTICOSTEROID_HORMONE_SECRETION","pval":0.86144,"padj":0.97645,"ES":0.5129,"NES":0.65115,"nMoreExtreme":48624,"size":10,"leadingEdge":["AGT","CRY1"]} {"pathway":"GO_AMYLOID_BETA_CLEARANCE","pval":0.96553,"padj":0.99537,"ES":0.46358,"NES":0.6511,"nMoreExtreme":62942,"size":30,"leadingEdge":["C3","CYP51A1"]} {"pathway":"GO_CONVERGENT_EXTENSION_INVOLVED_IN_AXIS_ELONGATION","pval":0.75476,"padj":0.9603,"ES":0.48663,"NES":0.65071,"nMoreExtreme":40507,"size":6,"leadingEdge":["SFRP1","WNT5A","TRIM28","NKD1","SFRP2","VANGL2"]} {"pathway":"GO_PROTEIN_DEGLUTAMYLATION","pval":0.69477,"padj":0.94995,"ES":0.45607,"NES":0.64947,"nMoreExtreme":36159,"size":4,"leadingEdge":["AGBL5","AGTPBP1","AGBL3","AGBL2"]} {"pathway":"GO_IRON_COORDINATION_ENTITY_TRANSPORT","pval":0.8448,"padj":0.97458,"ES":0.50806,"NES":0.64895,"nMoreExtreme":47210,"size":9,"leadingEdge":["FLVCR2","SLC22A17"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PLASMINOGEN_ACTIVATION","pval":0.71917,"padj":0.95459,"ES":0.47123,"NES":0.64822,"nMoreExtreme":38053,"size":5,"leadingEdge":["HPN","PLGRKT","ENO1"]} {"pathway":"GO_SELF_PROTEOLYSIS","pval":0.71936,"padj":0.95459,"ES":0.47098,"NES":0.64788,"nMoreExtreme":38063,"size":5,"leadingEdge":["CAPN1","CAPN3","LGMN","CAPN7","ADGRV1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_LIPID_TRANSPORT","pval":0.92383,"padj":0.987,"ES":0.50075,"NES":0.64758,"nMoreExtreme":55826,"size":17,"leadingEdge":["NR1H3","CRY1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS","pval":0.93311,"padj":0.98762,"ES":0.49382,"NES":0.64753,"nMoreExtreme":57309,"size":19,"leadingEdge":["TNF","PTAFR","CD244"]} {"pathway":"GO_PIGMENT_GRANULE_ORGANIZATION","pval":0.95554,"padj":0.9934,"ES":0.47416,"NES":0.64706,"nMoreExtreme":60871,"size":25,"leadingEdge":["DTNBP1","RAB38","TRAPPC6A"]} {"pathway":"GO_NUCLEAR_NCRNA_SURVEILLANCE","pval":0.75601,"padj":0.9603,"ES":0.4839,"NES":0.64705,"nMoreExtreme":40574,"size":6,"leadingEdge":["EXOSC7","EXOSC3","EXOSC8","EXOSC9","EXOSC2"]} {"pathway":"GO_MEIOTIC_CELL_CYCLE_CHECKPOINT","pval":0.7561,"padj":0.9603,"ES":0.48378,"NES":0.6469,"nMoreExtreme":40579,"size":6,"leadingEdge":["HORMAD1","NSUN2"]} {"pathway":"GO_REGULATION_OF_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS","pval":0.98506,"padj":0.99994,"ES":0.44503,"NES":0.64659,"nMoreExtreme":66264,"size":37,"leadingEdge":["KLF4","MIR503","PTGS2","TBXA2R"]} {"pathway":"GO_SNORNA_METABOLIC_PROCESS","pval":0.69692,"padj":0.94995,"ES":0.45366,"NES":0.64603,"nMoreExtreme":36271,"size":4,"leadingEdge":["FBL","DKC1","PARN","NOLC1"]} {"pathway":"GO_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS","pval":0.75642,"padj":0.9603,"ES":0.48288,"NES":0.6457,"nMoreExtreme":40596,"size":6,"leadingEdge":["ME1","ME2","DNM1L","TSPO","ATP5IF1"]} {"pathway":"GO_REGULATION_OF_RECEPTOR_CLUSTERING","pval":0.86437,"padj":0.97662,"ES":0.50824,"NES":0.64523,"nMoreExtreme":48789,"size":10,"leadingEdge":["TGFB1","SHISA7","PTN"]} {"pathway":"GO_MYELIN_ASSEMBLY","pval":0.92666,"padj":0.987,"ES":0.49809,"NES":0.64414,"nMoreExtreme":55997,"size":17,"leadingEdge":["ANK2","GPC1"]} {"pathway":"GO_GLUTAMATE_SECRETION","pval":0.98201,"padj":0.99935,"ES":0.44894,"NES":0.64361,"nMoreExtreme":65191,"size":34,"leadingEdge":["P2RX7","KMO","GLS","ADORA2A","TSPOAP1"]} {"pathway":"GO_PRE_B_CELL_DIFFERENTIATION","pval":0.69884,"padj":0.94995,"ES":0.45192,"NES":0.64355,"nMoreExtreme":36371,"size":4,"leadingEdge":["ATP11C","LRRC8A","ATM","RAG1"]} {"pathway":"GO_REGULATION_OF_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS","pval":0.90282,"padj":0.98417,"ES":0.50758,"NES":0.64319,"nMoreExtreme":52580,"size":13,"leadingEdge":["FPR2","PDGFB","RAB38","AGAP2"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_PHOTORECEPTOR_OUTER_SEGMENT","pval":0.69942,"padj":0.94995,"ES":0.45147,"NES":0.64291,"nMoreExtreme":36401,"size":4,"leadingEdge":["TULP3","BBS4","ZDHHC3","TUB"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CATECHOLAMINE_SECRETION","pval":0.75787,"padj":0.9603,"ES":0.48037,"NES":0.64233,"nMoreExtreme":40674,"size":6,"leadingEdge":["P2RY12","SYT4"]} {"pathway":"GO_ACTIN_POLYMERIZATION_DEPENDENT_CELL_MOTILITY","pval":0.75797,"padj":0.9603,"ES":0.48028,"NES":0.64222,"nMoreExtreme":40679,"size":6,"leadingEdge":["ARPC3","ACTR3","NCKAP1L","EPS8","JMY","ARPC2"]} {"pathway":"GO_CEREBRAL_CORTEX_GABAERGIC_INTERNEURON_DIFFERENTIATION","pval":0.75821,"padj":0.9603,"ES":0.47965,"NES":0.64137,"nMoreExtreme":40692,"size":6,"leadingEdge":["ASCL1","DLX2"]} {"pathway":"GO_REGULATION_OF_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY","pval":0.99522,"padj":1,"ES":0.43132,"NES":0.64106,"nMoreExtreme":68528,"size":43,"leadingEdge":["RASGRF1","ANXA3","ACTN2","CX3CL1","RGS9","SHISA7","ARC","MAPK8IP2","DLG3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION","pval":0.86695,"padj":0.97662,"ES":0.5048,"NES":0.64086,"nMoreExtreme":48935,"size":10,"leadingEdge":["DUSP10","HES1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_REPRODUCTIVE_PROCESS","pval":0.98925,"padj":1,"ES":0.44109,"NES":0.64086,"nMoreExtreme":66546,"size":37,"leadingEdge":["OVOL1","HORMAD1","NKX3-1","ASTL"]} {"pathway":"GO_CANONICAL_WNT_SIGNALING_PATHWAY_INVOLVED_IN_HEART_DEVELOPMENT","pval":0.72425,"padj":0.95562,"ES":0.43498,"NES":0.64085,"nMoreExtreme":37024,"size":3,"leadingEdge":["DKK1","CTNNB1","RBPJ"]} {"pathway":"GO_TROPHOBLAST_CELL_MIGRATION","pval":0.82561,"padj":0.97439,"ES":0.49642,"NES":0.64073,"nMoreExtreme":45491,"size":8,"leadingEdge":["TIMP1","SYDE1","C1QBP","SMURF2","ARHGDIB","AGO2","ACVR1B"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA1_PRODUCTION","pval":0.75875,"padj":0.9603,"ES":0.47854,"NES":0.63989,"nMoreExtreme":40721,"size":6,"leadingEdge":["CX3CL1","LUM"]} {"pathway":"GO_ABSCISSION","pval":0.75899,"padj":0.9603,"ES":0.47811,"NES":0.63932,"nMoreExtreme":40734,"size":6,"leadingEdge":["CHMP4C","VPS4A"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_ESTRADIOL_STIMULUS","pval":0.9664,"padj":0.99537,"ES":0.46524,"NES":0.63874,"nMoreExtreme":61832,"size":26,"leadingEdge":["SSTR2","CFLAR","CCDC62"]} {"pathway":"GO_REGULATION_OF_LIPOPROTEIN_LIPASE_ACTIVITY","pval":0.90615,"padj":0.98417,"ES":0.50396,"NES":0.63861,"nMoreExtreme":52774,"size":13,"leadingEdge":["NR1H3","ANGPTL4","SORT1","LMF1","ABHD5"]} {"pathway":"GO_SUGAR_MEDIATED_SIGNALING_PATHWAY","pval":0.7237,"padj":0.95562,"ES":0.46418,"NES":0.63851,"nMoreExtreme":38293,"size":5,"leadingEdge":["MLXIPL","SMARCB1","PIH1D1","SMARCA4"]} {"pathway":"GO_SECONDARY_PALATE_DEVELOPMENT","pval":0.94569,"padj":0.9905,"ES":0.48352,"NES":0.63835,"nMoreExtreme":58457,"size":20,"leadingEdge":["MMP25","TBX1"]} {"pathway":"GO_CARDIAC_PACEMAKER_CELL_DIFFERENTIATION","pval":0.70299,"padj":0.9504,"ES":0.4481,"NES":0.63811,"nMoreExtreme":36587,"size":4,"leadingEdge":["BVES","TBX3","MAML1","MESP1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY","pval":0.95354,"padj":0.9929,"ES":0.47657,"NES":0.63804,"nMoreExtreme":59664,"size":22,"leadingEdge":["GBP1","TGFB1","RHOQ"]} {"pathway":"GO_THYMOCYTE_APOPTOTIC_PROCESS","pval":0.93807,"padj":0.98783,"ES":0.48969,"NES":0.63775,"nMoreExtreme":57073,"size":18,"leadingEdge":["BCL2L11","JAK3","BAK1"]} {"pathway":"GO_REGULATION_OF_ASTROCYTE_ACTIVATION","pval":0.82704,"padj":0.97439,"ES":0.49402,"NES":0.63763,"nMoreExtreme":45570,"size":8,"leadingEdge":["IL6","LDLR"]} {"pathway":"GO_HYPOXIA_INDUCIBLE_FACTOR_1ALPHA_SIGNALING_PATHWAY","pval":0.72435,"padj":0.95562,"ES":0.46284,"NES":0.63667,"nMoreExtreme":38327,"size":5,"leadingEdge":["PDK3","HIF1A","RWDD3","PDK1","CYBB"]} {"pathway":"GO_THROMBIN_ACTIVATED_RECEPTOR_SIGNALING_PATHWAY","pval":0.8968,"padj":0.98354,"ES":0.50275,"NES":0.63665,"nMoreExtreme":51729,"size":12,"leadingEdge":["PLEK","F2RL2","GP1BA","MET"]} {"pathway":"GO_ALDITOL_BIOSYNTHETIC_PROCESS","pval":0.70413,"padj":0.9504,"ES":0.44706,"NES":0.63663,"nMoreExtreme":36646,"size":4,"leadingEdge":["AKR1B1","PCK2","GOT1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_CHEMOTAXIS_BY_VEGF_ACTIVATED_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY","pval":0.72442,"padj":0.95562,"ES":0.46266,"NES":0.63642,"nMoreExtreme":38331,"size":5,"leadingEdge":["PRKD2","HSPB1","VEGFA","KDR"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_INVOLVED_IN_HEART_DEVELOPMENT","pval":0.70442,"padj":0.9504,"ES":0.44669,"NES":0.63611,"nMoreExtreme":36661,"size":4,"leadingEdge":["SRF","GATA5","MYOCD","GREM1"]} {"pathway":"GO_SPINAL_CORD_ASSOCIATION_NEURON_DIFFERENTIATION","pval":0.79805,"padj":0.96646,"ES":0.48555,"NES":0.63513,"nMoreExtreme":43378,"size":7,"leadingEdge":["MDGA1","ASCL1","WNT1"]} {"pathway":"GO_FIBROBLAST_ACTIVATION","pval":0.82819,"padj":0.97439,"ES":0.492,"NES":0.63503,"nMoreExtreme":45633,"size":8,"leadingEdge":["GCLC","GCLM"]} {"pathway":"GO_TRIGLYCERIDE_METABOLIC_PROCESS","pval":0.97311,"padj":0.99756,"ES":0.45959,"NES":0.63484,"nMoreExtreme":62570,"size":27,"leadingEdge":["GK","PLAAT3","LMF1","INSIG2","CPT1A"]} {"pathway":"GO_PHOTORECEPTOR_CELL_DIFFERENTIATION","pval":0.99583,"padj":1,"ES":0.43147,"NES":0.63454,"nMoreExtreme":67880,"size":40,"leadingEdge":["SOX8","STAT3","RORB","PTN","PROM1"]} {"pathway":"GO_FATTY_ACID_ALPHA_OXIDATION","pval":0.79824,"padj":0.96646,"ES":0.48503,"NES":0.63445,"nMoreExtreme":43388,"size":7,"leadingEdge":["ALDH3A2","SLC25A17","PHYH","PECR","HACL1","SLC27A2","PEX13"]} {"pathway":"GO_RESPONSE_TO_MAGNESIUM_ION","pval":0.92346,"padj":0.987,"ES":0.49622,"NES":0.634,"nMoreExtreme":54874,"size":15,"leadingEdge":["SMPD3","CCND1"]} {"pathway":"GO_VERY_LONG_CHAIN_FATTY_ACID_CATABOLIC_PROCESS","pval":0.70634,"padj":0.9508,"ES":0.44495,"NES":0.63363,"nMoreExtreme":36761,"size":4,"leadingEdge":["ABCD1","ABCD3","SLC27A2","SLC27A4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_HISTONE_PHOSPHORYLATION","pval":0.82884,"padj":0.97439,"ES":0.49034,"NES":0.63288,"nMoreExtreme":45669,"size":8,"leadingEdge":["RPS6KA5","FMR1","MAPK3","IL1B","CCNB1","CDK9","ATM","RPS6KA4"]} {"pathway":"GO_TRANSEPITHELIAL_TRANSPORT","pval":0.91736,"padj":0.987,"ES":0.49729,"NES":0.63286,"nMoreExtreme":53996,"size":14,"leadingEdge":["EDN1","SLC12A2"]} {"pathway":"GO_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY","pval":0.95883,"padj":0.9934,"ES":0.47257,"NES":0.63268,"nMoreExtreme":59995,"size":22,"leadingEdge":["PML","ALDH1A2","TBX1","CYP26B1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PHOTORECEPTOR_CELL_DIFFERENTIATION","pval":0.7989,"padj":0.96646,"ES":0.48355,"NES":0.63252,"nMoreExtreme":43424,"size":7,"leadingEdge":["SOX8","DLX2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT","pval":0.98377,"padj":0.9997,"ES":0.44973,"NES":0.63165,"nMoreExtreme":64131,"size":30,"leadingEdge":["SRI","DYSF","GEM","TGFB1","CLIC2","GPR35"]} {"pathway":"GO_INTEGRIN_BIOSYNTHETIC_PROCESS","pval":0.73463,"padj":0.95787,"ES":0.42869,"NES":0.63159,"nMoreExtreme":37555,"size":3,"leadingEdge":["TGFB2","COL5A1","AR"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CARDIOCYTE_DIFFERENTIATION","pval":0.96687,"padj":0.99549,"ES":0.46565,"NES":0.63154,"nMoreExtreme":61233,"size":24,"leadingEdge":["EDN1","TGFB1","IGF1"]} {"pathway":"GO_TRANSFORMING_GROWTH_FACTOR_BETA_PRODUCTION","pval":0.9908,"padj":1,"ES":0.44025,"NES":0.63115,"nMoreExtreme":65774,"size":34,"leadingEdge":["PTGS2","CX3CL1","SMAD3","TYROBP"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_NUCLEASE_ACTIVITY","pval":0.76199,"padj":0.96082,"ES":0.47174,"NES":0.6308,"nMoreExtreme":40895,"size":6,"leadingEdge":["TERF2","TMBIM6","NEIL1","TERF1","DFFA","ABCE1"]} {"pathway":"GO_AMINO_SUGAR_CATABOLIC_PROCESS","pval":0.79954,"padj":0.96646,"ES":0.48216,"NES":0.63071,"nMoreExtreme":43459,"size":7,"leadingEdge":["OVGP1","GNPDA1","CTBS","MGAT1","CHIT1","AMDHD2","GNPDA2"]} {"pathway":"GO_GONADAL_MESODERM_DEVELOPMENT","pval":0.79259,"padj":0.96486,"ES":0.42277,"NES":0.63059,"nMoreExtreme":39829,"size":2,"leadingEdge":["AMH","ZFPM2"]} {"pathway":"GO_ISOPENTENYL_DIPHOSPHATE_BIOSYNTHETIC_PROCESS","pval":0.70914,"padj":0.95188,"ES":0.44231,"NES":0.62987,"nMoreExtreme":36907,"size":4,"leadingEdge":["IDI1","MVK","PMVK","MVD"]} {"pathway":"GO_POSTSYNAPSE_ASSEMBLY","pval":0.96878,"padj":0.99598,"ES":0.46394,"NES":0.62921,"nMoreExtreme":61354,"size":24,"leadingEdge":["NTNG2","PTPRS"]} {"pathway":"GO_AMYLOID_BETA_CLEARANCE_BY_CELLULAR_CATABOLIC_PROCESS","pval":0.80026,"padj":0.96646,"ES":0.48083,"NES":0.62896,"nMoreExtreme":43498,"size":7,"leadingEdge":["ABCA7","IDE","LRP1","LDLR","LRP4","CD36"]} {"pathway":"GO_PHENOL_CONTAINING_COMPOUND_METABOLIC_PROCESS","pval":0.99658,"padj":1,"ES":0.43079,"NES":0.62855,"nMoreExtreme":67386,"size":38,"leadingEdge":["NPR1","HPN","NR4A2","GATA3"]} {"pathway":"GO_REGULATION_OF_EXCITATORY_SYNAPSE_ASSEMBLY","pval":0.85549,"padj":0.97645,"ES":0.49095,"NES":0.62709,"nMoreExtreme":47807,"size":9,"leadingEdge":["SEMA4A","PTPRS"]} {"pathway":"GO_POLYPHOSPHATE_CATABOLIC_PROCESS","pval":0.7112,"padj":0.95246,"ES":0.44023,"NES":0.62691,"nMoreExtreme":37014,"size":4,"leadingEdge":["PRUNE2","BNIP2","PRUNE1","ATCAY"]} {"pathway":"GO_REGULATION_OF_RYANODINE_SENSITIVE_CALCIUM_RELEASE_CHANNEL_ACTIVITY","pval":0.97139,"padj":0.99706,"ES":0.46196,"NES":0.62654,"nMoreExtreme":61519,"size":24,"leadingEdge":["CAMK2D","SRI","JPH4","CLIC2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_IRE1_MEDIATED_UNFOLDED_PROTEIN_RESPONSE","pval":0.80096,"padj":0.96646,"ES":0.47897,"NES":0.62653,"nMoreExtreme":43536,"size":7,"leadingEdge":["BCL2L11","PTPN1","BAK1"]} {"pathway":"GO_NOREPINEPHRINE_TRANSPORT","pval":0.92241,"padj":0.987,"ES":0.49222,"NES":0.6264,"nMoreExtreme":54293,"size":14,"leadingEdge":["AGT","P2RY12","SLC22A1","ADORA2A"]} {"pathway":"GO_ANDROGEN_METABOLIC_PROCESS","pval":0.83173,"padj":0.97439,"ES":0.48519,"NES":0.62625,"nMoreExtreme":45828,"size":8,"leadingEdge":["DHRS9","ESR1"]} {"pathway":"GO_RIBOSOMAL_SMALL_SUBUNIT_EXPORT_FROM_NUCLEUS","pval":0.80124,"padj":0.96646,"ES":0.47841,"NES":0.6258,"nMoreExtreme":43551,"size":7,"leadingEdge":["RIOK2","XPO1","NUP88","RPS15","RAN","LTV1"]} {"pathway":"GO_PLASMINOGEN_ACTIVATION","pval":0.9228,"padj":0.987,"ES":0.49173,"NES":0.62577,"nMoreExtreme":54316,"size":14,"leadingEdge":["CTSZ","HPN","PLGRKT","ENO1"]} {"pathway":"GO_RESPONSE_TO_AMINE","pval":0.99091,"padj":1,"ES":0.44089,"NES":0.62573,"nMoreExtreme":65164,"size":32,"leadingEdge":["ICAM1","NR4A2","RGS9","ASS1","ADORA2A"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELL_GROWTH_INVOLVED_IN_CARDIAC_MUSCLE_CELL_DEVELOPMENT","pval":0.83189,"padj":0.97439,"ES":0.48477,"NES":0.6257,"nMoreExtreme":45837,"size":8,"leadingEdge":["EDN1","IGF1"]} {"pathway":"GO_RIBOSOMAL_PROTEIN_IMPORT_INTO_NUCLEUS","pval":0.83189,"padj":0.97439,"ES":0.48473,"NES":0.62565,"nMoreExtreme":45837,"size":8,"leadingEdge":["IPO5","TNPO1","IPO11","TNPO2","KPNB1","RPL23","RANBP6"]} {"pathway":"GO_FOREBRAIN_NEURON_FATE_COMMITMENT","pval":0.80129,"padj":0.96646,"ES":0.4782,"NES":0.62552,"nMoreExtreme":43554,"size":7,"leadingEdge":["ASCL1","DLX2"]} {"pathway":"GO_EOSINOPHIL_ACTIVATION","pval":0.80129,"padj":0.96646,"ES":0.4781,"NES":0.62539,"nMoreExtreme":43554,"size":7,"leadingEdge":["CCL3","STX4"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PROTEIN_FOLDING","pval":0.7293,"padj":0.95596,"ES":0.45408,"NES":0.62462,"nMoreExtreme":38589,"size":5,"leadingEdge":["ST13","SNRNP70","PDCD5","PDCL","BAG5"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_PRODUCTION","pval":0.9385,"padj":0.98783,"ES":0.48579,"NES":0.62408,"nMoreExtreme":56218,"size":16,"leadingEdge":["PTGS2","CX3CL1","SMAD3","CD200"]} {"pathway":"GO_OXIDATIVE_RNA_DEMETHYLATION","pval":0.72952,"padj":0.95596,"ES":0.45363,"NES":0.624,"nMoreExtreme":38601,"size":5,"leadingEdge":["JMJD6","ALKBH5","ALKBH1","FTO","ALKBH3"]} {"pathway":"GO_PROSTATE_GLANDULAR_ACINUS_MORPHOGENESIS","pval":0.7296,"padj":0.95596,"ES":0.45346,"NES":0.62377,"nMoreExtreme":38605,"size":5,"leadingEdge":["FGFR2","ESR1","SFRP1","HOXB13","FRS2"]} {"pathway":"GO_SCARNA_LOCALIZATION_TO_CAJAL_BODY","pval":0.72964,"padj":0.95596,"ES":0.4534,"NES":0.62369,"nMoreExtreme":38607,"size":5,"leadingEdge":["CCT4","TCP1","DKC1","WRAP53","CCT2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PROTEIN_OLIGOMERIZATION","pval":0.90496,"padj":0.98417,"ES":0.49245,"NES":0.62359,"nMoreExtreme":52200,"size":12,"leadingEdge":["SRC","VPS35"]} {"pathway":"GO_URETER_DEVELOPMENT","pval":0.92526,"padj":0.987,"ES":0.48929,"NES":0.62266,"nMoreExtreme":54461,"size":14,"leadingEdge":["SOX8","GATA3","ALDH1A2","SIX1"]} {"pathway":"GO_NAIL_DEVELOPMENT","pval":0.76523,"padj":0.96082,"ES":0.46506,"NES":0.62186,"nMoreExtreme":41069,"size":6,"leadingEdge":["ITGA6","PRKAB1","MSX2","ITGB4","MSX1","FZD6"]} {"pathway":"GO_PROTEIN_DESUMOYLATION","pval":0.8021,"padj":0.96646,"ES":0.47531,"NES":0.62174,"nMoreExtreme":43598,"size":7,"leadingEdge":["SENP1","SENP6","SENP5","USPL1","SENP7","SENP3","SENP2"]} {"pathway":"GO_ANATOMICAL_STRUCTURE_REGRESSION","pval":0.85822,"padj":0.97645,"ES":0.48652,"NES":0.62143,"nMoreExtreme":47960,"size":9,"leadingEdge":["SPI1","GLI2","AMH","BMPR1A","GLI1","SMAD5","NINJ1","LEF1"]} {"pathway":"GO_MESENCHYMAL_CELL_PROLIFERATION_INVOLVED_IN_LUNG_DEVELOPMENT","pval":0.71548,"padj":0.95345,"ES":0.43619,"NES":0.62115,"nMoreExtreme":37237,"size":4,"leadingEdge":["FGFR2","PHF14","NFIB","CTNNB1"]} {"pathway":"GO_REGULATION_OF_HISTONE_PHOSPHORYLATION","pval":0.90659,"padj":0.98422,"ES":0.49045,"NES":0.62106,"nMoreExtreme":52294,"size":12,"leadingEdge":["AKAP8L","RPS6KA5","FMR1","MAPK3","AKAP8","UBE2B","TWIST1","IL1B","CCNB1","CDK9","ATM","RPS6KA4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_PRODUCTION","pval":0.97292,"padj":0.99756,"ES":0.46085,"NES":0.62104,"nMoreExtreme":61213,"size":23,"leadingEdge":["C3","TGFB1","PTGS2","IL1A"]} {"pathway":"GO_CELLULAR_ANION_HOMEOSTASIS","pval":0.76579,"padj":0.96082,"ES":0.4638,"NES":0.62018,"nMoreExtreme":41099,"size":6,"leadingEdge":["CKB","FGF23"]} {"pathway":"GO_KETONE_BODY_BIOSYNTHETIC_PROCESS","pval":0.80267,"padj":0.96646,"ES":0.47385,"NES":0.61983,"nMoreExtreme":43629,"size":7,"leadingEdge":["ACAT1","AACS","SLC27A5","ACSS3","HMGCL","BDH1","BDH2"]} {"pathway":"GO_NOTCH_RECEPTOR_PROCESSING","pval":0.8787,"padj":0.97973,"ES":0.48818,"NES":0.61976,"nMoreExtreme":49598,"size":10,"leadingEdge":["PSEN2","PSEN1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT","pval":0.83425,"padj":0.97443,"ES":0.48,"NES":0.61954,"nMoreExtreme":45967,"size":8,"leadingEdge":["RIOK2","RBM27","CPSF6","NCBP2","KHDRBS1","DHX9","RBM26","ADORA1"]} {"pathway":"GO_POSTSYNAPTIC_SPECIALIZATION_ORGANIZATION","pval":0.99012,"padj":1,"ES":0.44344,"NES":0.61954,"nMoreExtreme":64252,"size":29,"leadingEdge":["NTNG2","LILRB2","DLG3"]} {"pathway":"GO_GABAERGIC_NEURON_DIFFERENTIATION","pval":0.8344,"padj":0.97443,"ES":0.47964,"NES":0.61908,"nMoreExtreme":45975,"size":8,"leadingEdge":["ASCL1","DLX2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION","pval":0.97107,"padj":0.99701,"ES":0.46235,"NES":0.619,"nMoreExtreme":60761,"size":22,"leadingEdge":["GPR18","F2RL2","ROBO1","LPAR1","GPR35"]} {"pathway":"GO_SYNAPTIC_VESICLE_MATURATION","pval":0.90879,"padj":0.98471,"ES":0.48832,"NES":0.61837,"nMoreExtreme":52421,"size":12,"leadingEdge":["PICALM","SYP","ZDHHC15","SLC17A7","RAB3A","CLCN3","UNC13A","DLG4","STXBP1","UNC13C","SNAPIN"]} {"pathway":"GO_IRIS_MORPHOGENESIS","pval":0.80332,"padj":0.96646,"ES":0.47261,"NES":0.61821,"nMoreExtreme":43664,"size":7,"leadingEdge":["HIPK2","HIF1A","WNT2","WNT2B","WNT9A","HIPK1","PITX2"]} {"pathway":"GO_CHANGES_TO_DNA_METHYLATION_INVOLVED_IN_EMBRYO_DEVELOPMENT","pval":0.73285,"padj":0.95712,"ES":0.44901,"NES":0.61765,"nMoreExtreme":38777,"size":5,"leadingEdge":["PICK1","DNMT3A","TRIM28","DNMT1"]} {"pathway":"GO_REGULATION_OF_PHOTORECEPTOR_CELL_DIFFERENTIATION","pval":0.85983,"padj":0.97645,"ES":0.48355,"NES":0.61764,"nMoreExtreme":48050,"size":9,"leadingEdge":["SOX8","CRX"]} {"pathway":"GO_RESPONSE_TO_CAFFEINE","pval":0.90942,"padj":0.98498,"ES":0.48763,"NES":0.6175,"nMoreExtreme":52457,"size":12,"leadingEdge":["SLC8A1","ADORA2A"]} {"pathway":"GO_POLYADENYLATION_DEPENDENT_RNA_CATABOLIC_PROCESS","pval":0.83503,"padj":0.97443,"ES":0.47782,"NES":0.61673,"nMoreExtreme":46010,"size":8,"leadingEdge":["EXOSC7","EXOSC3","EXOSC8","TENT4B","EXOSC9","EXOSC2","PNPT1"]} {"pathway":"GO_CHAPERONE_MEDIATED_PROTEIN_TRANSPORT","pval":0.89687,"padj":0.98354,"ES":0.48688,"NES":0.61654,"nMoreExtreme":51210,"size":11,"leadingEdge":["TIMM13","TIMM9","CLIP3","HSPA8","CLU","TIMM8A","TIMM10","TOR1A","TIMM8B","BAG3","PEX19"]} {"pathway":"GO_REGULATION_OF_NITRIC_OXIDE_MEDIATED_SIGNAL_TRANSDUCTION","pval":0.83561,"padj":0.97443,"ES":0.47674,"NES":0.61533,"nMoreExtreme":46042,"size":8,"leadingEdge":["GUCY1A1","SPINK1","ATP2B4"]} {"pathway":"GO_REGULATION_OF_CELL_CELL_ADHESION_MEDIATED_BY_CADHERIN","pval":0.91075,"padj":0.98532,"ES":0.48592,"NES":0.61533,"nMoreExtreme":52534,"size":12,"leadingEdge":["PTPRU","FLOT1"]} {"pathway":"GO_FATTY_ACID_DERIVATIVE_CATABOLIC_PROCESS","pval":0.76764,"padj":0.96082,"ES":0.45993,"NES":0.615,"nMoreExtreme":41198,"size":6,"leadingEdge":["ACAT1","OXCT1","ACOT7","ABCD1"]} {"pathway":"GO_NEURON_CELLULAR_HOMEOSTASIS","pval":0.98622,"padj":0.99994,"ES":0.44793,"NES":0.61499,"nMoreExtreme":63100,"size":26,"leadingEdge":["IL6","AUTS2","CX3CL1","TSPOAP1"]} {"pathway":"GO_ASTRAL_MICROTUBULE_ORGANIZATION","pval":0.80442,"padj":0.96671,"ES":0.47011,"NES":0.61495,"nMoreExtreme":43724,"size":7,"leadingEdge":["CLASP1","DLG1","EZR","RAB11A","KPNB1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_OF_NOTCH_RECEPTOR_TARGET","pval":0.95226,"padj":0.99283,"ES":0.47531,"NES":0.61468,"nMoreExtreme":57544,"size":17,"leadingEdge":["STAT1","MAML2","CREBBP"]} {"pathway":"GO_FRUCTOSE_2_6_BISPHOSPHATE_METABOLIC_PROCESS","pval":0.72042,"padj":0.95459,"ES":0.4315,"NES":0.61447,"nMoreExtreme":37494,"size":4,"leadingEdge":["TIGAR","PFKFB4","PFKFB2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_MICROTUBULE","pval":0.73464,"padj":0.95787,"ES":0.44627,"NES":0.61388,"nMoreExtreme":38872,"size":5,"leadingEdge":["ABHD17B","TTBK2","ABHD17A","ABHD17C","MAP1A"]} {"pathway":"GO_RESPONSE_TO_HEPATOCYTE_GROWTH_FACTOR","pval":0.95289,"padj":0.9929,"ES":0.47462,"NES":0.61379,"nMoreExtreme":57582,"size":17,"leadingEdge":["HGF","GCLC","GCLM"]} {"pathway":"GO_I_KAPPAB_PHOSPHORYLATION","pval":0.95304,"padj":0.9929,"ES":0.47436,"NES":0.61345,"nMoreExtreme":57591,"size":17,"leadingEdge":["TLR7","TLR3","IKBKE","CX3CL1","TLR4"]} {"pathway":"GO_REGULATION_OF_POSTSYNAPTIC_NEUROTRANSMITTER_RECEPTOR_ACTIVITY","pval":0.89883,"padj":0.98387,"ES":0.48415,"NES":0.61308,"nMoreExtreme":51322,"size":11,"leadingEdge":["SRC","SHISA7","NPTX1"]} {"pathway":"GO_SNRNA_TRANSCRIPTION_BY_RNA_POLYMERASE_III","pval":0.76831,"padj":0.96082,"ES":0.45831,"NES":0.61285,"nMoreExtreme":41234,"size":6,"leadingEdge":["SNAPC1","ELL","ICE2","ZC3H8","ICE1","SNAPC4"]} {"pathway":"GO_REGULATION_OF_GLUCOCORTICOID_RECEPTOR_SIGNALING_PATHWAY","pval":0.73517,"padj":0.95787,"ES":0.44548,"NES":0.61279,"nMoreExtreme":38900,"size":5,"leadingEdge":["CRY1","CRY2","ARNTL","CLOCK","PHB"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PLATELET_ACTIVATION","pval":0.93232,"padj":0.98762,"ES":0.48141,"NES":0.61264,"nMoreExtreme":54876,"size":14,"leadingEdge":["CEACAM1","PDGFRA","PDGFB"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MITOPHAGY","pval":0.76877,"padj":0.96082,"ES":0.4576,"NES":0.6119,"nMoreExtreme":41259,"size":6,"leadingEdge":["CLEC16A","TIGAR","TSC2","HTRA2","USP30"]} {"pathway":"GO_CELLULAR_KETONE_BODY_METABOLIC_PROCESS","pval":0.83655,"padj":0.97458,"ES":0.47387,"NES":0.61163,"nMoreExtreme":46094,"size":8,"leadingEdge":["ACAT1","AACS","OXCT1","SLC27A5","ACSS3","HMGCL","BDH1","BDH2"]} {"pathway":"GO_NEPHRON_TUBULE_EPITHELIAL_CELL_DIFFERENTIATION","pval":0.9333,"padj":0.98762,"ES":0.48025,"NES":0.61117,"nMoreExtreme":54934,"size":14,"leadingEdge":["STAT1","GATA3","PROM1"]} {"pathway":"GO_FOREBRAIN_RADIAL_GLIAL_CELL_DIFFERENTIATION","pval":0.7692,"padj":0.96082,"ES":0.45685,"NES":0.61089,"nMoreExtreme":41282,"size":6,"leadingEdge":["RHOA","GLI3","HES1","LEF1","METTL14","METTL3"]} {"pathway":"GO_REGULATION_OF_PHOSPHATIDYLINOSITOL_BIOSYNTHETIC_PROCESS","pval":0.77004,"padj":0.96082,"ES":0.45471,"NES":0.60802,"nMoreExtreme":41327,"size":6,"leadingEdge":["FPR2","PDGFB","AGAP2"]} {"pathway":"GO_REGULATION_OF_IRE1_MEDIATED_UNFOLDED_PROTEIN_RESPONSE","pval":0.9159,"padj":0.987,"ES":0.47895,"NES":0.6065,"nMoreExtreme":52831,"size":12,"leadingEdge":["BCL2L11","PTPN1","BAK1","HSPA5"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_DIFFERENTIATION","pval":0.96448,"padj":0.99537,"ES":0.46567,"NES":0.60647,"nMoreExtreme":58680,"size":18,"leadingEdge":["EDN1","TGFB1","IGF1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CYCLASE_ACTIVITY","pval":0.95903,"padj":0.9934,"ES":0.46867,"NES":0.60609,"nMoreExtreme":57953,"size":17,"leadingEdge":["GUCA1A","NOS2"]} {"pathway":"GO_TRANSFORMING_GROWTH_FACTOR_BETA1_PRODUCTION","pval":0.90222,"padj":0.98417,"ES":0.47852,"NES":0.60596,"nMoreExtreme":51516,"size":11,"leadingEdge":["CX3CL1","TYROBP"]} {"pathway":"GO_REGULATION_OF_GLUTAMINE_FAMILY_AMINO_ACID_METABOLIC_PROCESS","pval":0.73907,"padj":0.95841,"ES":0.44026,"NES":0.60561,"nMoreExtreme":39106,"size":5,"leadingEdge":["ATP2B4","SIRT4","SLC7A11","SLC7A7","ATCAY"]} {"pathway":"GO_HISTONE_H2A_K63_LINKED_UBIQUITINATION","pval":0.73975,"padj":0.95899,"ES":0.43908,"NES":0.60398,"nMoreExtreme":39142,"size":5,"leadingEdge":["UBR5","RNF8","TRIP12","RNF168","OTUB1"]} {"pathway":"GO_EXCITATORY_SYNAPSE_ASSEMBLY","pval":0.96119,"padj":0.9934,"ES":0.4663,"NES":0.60303,"nMoreExtreme":58084,"size":17,"leadingEdge":["SEMA4A","PTPRS"]} {"pathway":"GO_DORSAL_SPINAL_CORD_DEVELOPMENT","pval":0.93055,"padj":0.98762,"ES":0.47532,"NES":0.60232,"nMoreExtreme":54195,"size":13,"leadingEdge":["MDGA1","ASCL1","PROX1","WNT1"]} {"pathway":"GO_HEPARIN_BIOSYNTHETIC_PROCESS","pval":0.77213,"padj":0.96087,"ES":0.45028,"NES":0.6021,"nMoreExtreme":41439,"size":6,"leadingEdge":["XYLT2","NDST1","GLCE","CSGALNACT1","ANGPT1","NDST2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_LYASE_ACTIVITY","pval":0.95571,"padj":0.9934,"ES":0.46867,"NES":0.60208,"nMoreExtreme":57249,"size":16,"leadingEdge":["GUCA1A","NOS2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TROPHOBLAST_CELL_MIGRATION","pval":0.76812,"padj":0.96082,"ES":0.40845,"NES":0.60177,"nMoreExtreme":39267,"size":3,"leadingEdge":["TIMP1","ARHGDIB"]} {"pathway":"GO_MACROMOLECULE_DEPALMITOYLATION","pval":0.88727,"padj":0.98086,"ES":0.47378,"NES":0.60148,"nMoreExtreme":50082,"size":10,"leadingEdge":["LYPLA2","ABHD12","ABHD17B","LYPLA1","ABHD17A","PPT1","ABHD17C","ABHD13","LYPLAL1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE","pval":0.93108,"padj":0.98762,"ES":0.4745,"NES":0.60127,"nMoreExtreme":54226,"size":13,"leadingEdge":["SOD2","KCNK6"]} {"pathway":"GO_ADHERENS_JUNCTION_MAINTENANCE","pval":0.77257,"padj":0.96098,"ES":0.44921,"NES":0.60068,"nMoreExtreme":41463,"size":6,"leadingEdge":["PKP2","CAMSAP3","RASSF8","KIFC3","INAVA","PLEKHA7"]} {"pathway":"GO_MESODERMAL_CELL_FATE_COMMITMENT","pval":0.93206,"padj":0.98762,"ES":0.47324,"NES":0.59968,"nMoreExtreme":54283,"size":13,"leadingEdge":["KLF4","HOXA11"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_LYASE_ACTIVITY","pval":0.95735,"padj":0.9934,"ES":0.4667,"NES":0.59955,"nMoreExtreme":57347,"size":16,"leadingEdge":["P2RY13","PHPT1"]} {"pathway":"GO_CONVERGENT_EXTENSION_INVOLVED_IN_ORGANOGENESIS","pval":0.77309,"padj":0.96098,"ES":0.44815,"NES":0.59925,"nMoreExtreme":41491,"size":6,"leadingEdge":["DVL2","DVL1","WNT5A","VANGL2","FRZB","MESP1"]} {"pathway":"GO_REGULATION_OF_SODIUM_DEPENDENT_PHOSPHATE_TRANSPORT","pval":0.77108,"padj":0.96084,"ES":0.40639,"NES":0.59873,"nMoreExtreme":39418,"size":3,"leadingEdge":["CRY2","ATF4","CEBPB"]} {"pathway":"GO_REGULATION_OF_AMPA_RECEPTOR_ACTIVITY","pval":0.96482,"padj":0.99537,"ES":0.46146,"NES":0.59677,"nMoreExtreme":58303,"size":17,"leadingEdge":["SHISA7","ARC","MAPK8IP2","CACNG4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELLULAR_EXTRAVASATION","pval":0.9336,"padj":0.98762,"ES":0.47084,"NES":0.59664,"nMoreExtreme":54373,"size":13,"leadingEdge":["ICAM1","PTAFR","RIPOR2"]} {"pathway":"GO_POSTSYNAPTIC_SPECIALIZATION_ASSEMBLY","pval":0.95918,"padj":0.9934,"ES":0.46396,"NES":0.59603,"nMoreExtreme":57457,"size":16,"leadingEdge":["NTNG2","PTPRS"]} {"pathway":"GO_REGULATION_OF_L_GLUTAMATE_IMPORT_ACROSS_PLASMA_MEMBRANE","pval":0.73581,"padj":0.95787,"ES":0.41821,"NES":0.59555,"nMoreExtreme":38295,"size":4,"leadingEdge":["PSEN1","PER2","ARL6IP5","ARL6IP1"]} {"pathway":"GO_REGULATION_OF_CALCIUM_TRANSPORTING_ATPASE_ACTIVITY","pval":0.73694,"padj":0.95787,"ES":0.41717,"NES":0.59407,"nMoreExtreme":38354,"size":4,"leadingEdge":["THADA","SUMO1","HSPA2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVITY","pval":0.94405,"padj":0.98962,"ES":0.4667,"NES":0.59393,"nMoreExtreme":55567,"size":14,"leadingEdge":["P2RY13","GNAI3"]} {"pathway":"GO_RETROGRADE_NEURONAL_DENSE_CORE_VESICLE_TRANSPORT","pval":0.73748,"padj":0.95787,"ES":0.41686,"NES":0.59363,"nMoreExtreme":38382,"size":4,"leadingEdge":["KIF1B","KIF1C","KIF1A","KIF5B"]} {"pathway":"GO_NEURAL_FOLD_FORMATION","pval":0.77753,"padj":0.96098,"ES":0.40274,"NES":0.59335,"nMoreExtreme":39748,"size":3,"leadingEdge":["HIF1A","LUZP1","CFL1"]} {"pathway":"GO_TOLL_LIKE_RECEPTOR_3_SIGNALING_PATHWAY","pval":0.97711,"padj":0.99889,"ES":0.45204,"NES":0.59275,"nMoreExtreme":60011,"size":19,"leadingEdge":["TNFAIP3","TLR3","WDFY1","FLOT1","TICAM1"]} {"pathway":"GO_T_HELPER_1_CELL_CYTOKINE_PRODUCTION","pval":0.77546,"padj":0.96098,"ES":0.44325,"NES":0.5927,"nMoreExtreme":41618,"size":6,"leadingEdge":["IL18RAP","IL12B"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MONOCYTE_DIFFERENTIATION","pval":0.74621,"padj":0.96025,"ES":0.43003,"NES":0.59154,"nMoreExtreme":39484,"size":5,"leadingEdge":["CDK6","GPR68","ZBTB46","MYC","INPP5D"]} {"pathway":"GO_INTERKINETIC_NUCLEAR_MIGRATION","pval":0.74651,"padj":0.96025,"ES":0.42975,"NES":0.59116,"nMoreExtreme":39500,"size":5,"leadingEdge":["PCM1","DOCK7","KIF1A","HOOK3","CEP120"]} {"pathway":"GO_REGULATION_OF_CENTRIOLE_ELONGATION","pval":0.74651,"padj":0.96025,"ES":0.42975,"NES":0.59116,"nMoreExtreme":39500,"size":5,"leadingEdge":["VPS4B","CHMP2A","CENPJ","CEP295","CEP120"]} {"pathway":"GO_OUTER_MITOCHONDRIAL_MEMBRANE_ORGANIZATION","pval":0.77636,"padj":0.96098,"ES":0.44139,"NES":0.59021,"nMoreExtreme":41666,"size":6,"leadingEdge":["HSP90AA1","TOMM22","SAMM50","PDCD5"]} {"pathway":"GO_MAMMARY_GLAND_BRANCHING_INVOLVED_IN_PREGNANCY","pval":0.74731,"padj":0.96029,"ES":0.42874,"NES":0.58977,"nMoreExtreme":39542,"size":5,"leadingEdge":["ESR1","VDR","MED1","WNT4","AR"]} {"pathway":"GO_LACTATE_METABOLIC_PROCESS","pval":0.74731,"padj":0.96029,"ES":0.42873,"NES":0.58975,"nMoreExtreme":39542,"size":5,"leadingEdge":["HIF1A","PFKFB2","MRS2","LDHA"]} {"pathway":"GO_ALDEHYDE_CATABOLIC_PROCESS","pval":0.8122,"padj":0.97053,"ES":0.44993,"NES":0.58854,"nMoreExtreme":44147,"size":7,"leadingEdge":["ALDH3B1","HAGH","GPI","AKR1A1","PNKD","ESD"]} {"pathway":"GO_ENDOSOME_TO_LYSOSOME_TRANSPORT_VIA_MULTIVESICULAR_BODY_SORTING_PATHWAY","pval":0.77691,"padj":0.96098,"ES":0.44011,"NES":0.58851,"nMoreExtreme":41696,"size":6,"leadingEdge":["CHMP2B","CHMP3","VPS4B","LYST","VCP","UBXN6"]} {"pathway":"GO_REGULATION_OF_DOPAMINE_UPTAKE_INVOLVED_IN_SYNAPTIC_TRANSMISSION","pval":0.74823,"padj":0.9603,"ES":0.42767,"NES":0.5883,"nMoreExtreme":39591,"size":5,"leadingEdge":["DRD4","TOR1A","SNCA","GDNF","RAB3B"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_GLYCOLYTIC_PROCESS","pval":0.81233,"padj":0.97053,"ES":0.4493,"NES":0.58772,"nMoreExtreme":44154,"size":7,"leadingEdge":["STAT3","HDAC4"]} {"pathway":"GO_PANCREATIC_A_CELL_DIFFERENTIATION","pval":0.78534,"padj":0.96311,"ES":0.39836,"NES":0.5869,"nMoreExtreme":40147,"size":3,"leadingEdge":["HES1","GATA6","INSM1"]} {"pathway":"GO_SODIUM_DEPENDENT_PHOSPHATE_TRANSPORT","pval":0.74232,"padj":0.95912,"ES":0.41212,"NES":0.58687,"nMoreExtreme":38634,"size":4,"leadingEdge":["SLC17A7","CRY2","ATF4"]} {"pathway":"GO_CARDIAC_VASCULAR_SMOOTH_MUSCLE_CELL_DIFFERENTIATION","pval":0.81272,"padj":0.97053,"ES":0.44817,"NES":0.58624,"nMoreExtreme":44175,"size":7,"leadingEdge":["SRF","VEGFA","MYOCD","GATA6","NOTCH1","GPER1","MESP1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SYNAPSE_ASSEMBLY","pval":0.74925,"padj":0.9603,"ES":0.42616,"NES":0.58621,"nMoreExtreme":39645,"size":5,"leadingEdge":["DKK1","WNT5A","EPHA7","TLR2","PTK2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS","pval":0.84479,"padj":0.97458,"ES":0.45391,"NES":0.58586,"nMoreExtreme":46548,"size":8,"leadingEdge":["FPR2","RAB38","AGAP2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CHOLESTEROL_BIOSYNTHETIC_PROCESS","pval":0.77766,"padj":0.96098,"ES":0.43787,"NES":0.5855,"nMoreExtreme":41736,"size":6,"leadingEdge":["SREBF1","FGF1","POR","PRKAA1","ABCG1","CYP7A1"]} {"pathway":"GO_CEREBELLAR_PURKINJE_CELL_GRANULE_CELL_PRECURSOR_CELL_SIGNALING_INVOLVED_IN_REGULATION_OF_GRANULE_CELL_PRECURSOR_CELL_PROLIFERATION","pval":0.74371,"padj":0.95959,"ES":0.41082,"NES":0.58503,"nMoreExtreme":38706,"size":4,"leadingEdge":["GLI2","GLI1","SMO"]} {"pathway":"GO_RECEPTOR_DIFFUSION_TRAPPING","pval":0.74471,"padj":0.95978,"ES":0.41007,"NES":0.58395,"nMoreExtreme":38758,"size":4,"leadingEdge":["CACNG4","DLG4","CACNG8","GPHN"]} {"pathway":"GO_XYLULOSE_5_PHOSPHATE_BIOSYNTHETIC_PROCESS","pval":0.75061,"padj":0.9603,"ES":0.4243,"NES":0.58366,"nMoreExtreme":39717,"size":5,"leadingEdge":["XYLB","AKR1A1","SORD","CRYL1","DCXR"]} {"pathway":"GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_INVOLVED_IN_MYOCARDIAL_PRECURSOR_CELL_DIFFERENTIATION","pval":0.779,"padj":0.96098,"ES":0.43506,"NES":0.58175,"nMoreExtreme":41808,"size":6,"leadingEdge":["SRF","TBX2","MYOCD","NOTCH1","GREM1","RBPJ"]} {"pathway":"GO_MITOCHONDRIAL_ACETYL_COA_BIOSYNTHETIC_PROCESS_FROM_PYRUVATE","pval":0.77932,"padj":0.96107,"ES":0.43404,"NES":0.58039,"nMoreExtreme":41825,"size":6,"leadingEdge":["MPC1","DLD","PDHX","PDHA1","MPC2","PDHB"]} {"pathway":"GO_ADENOHYPOPHYSIS_DEVELOPMENT","pval":0.75286,"padj":0.9603,"ES":0.42143,"NES":0.57971,"nMoreExtreme":39836,"size":5,"leadingEdge":["SOX2","HES1"]} {"pathway":"GO_NEUTROPHIL_MEDIATED_KILLING_OF_SYMBIONT_CELL","pval":0.74866,"padj":0.9603,"ES":0.40636,"NES":0.57867,"nMoreExtreme":38964,"size":4,"leadingEdge":["TUSC2","CXCL6","F2RL1","AZU1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS","pval":0.79711,"padj":0.96646,"ES":0.39145,"NES":0.57672,"nMoreExtreme":40749,"size":3,"leadingEdge":["FCGR2B","SELENOS","IL20RB"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELL_AGING","pval":0.98948,"padj":1,"ES":0.43373,"NES":0.57659,"nMoreExtreme":61581,"size":21,"leadingEdge":["BCL6","NAMPT","WNT1"]} {"pathway":"GO_PENTOSE_METABOLIC_PROCESS","pval":0.75101,"padj":0.9603,"ES":0.40445,"NES":0.57595,"nMoreExtreme":39086,"size":4,"leadingEdge":["XYLB","RPIA","DCXR","FGGY"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_TELOMERE","pval":0.89643,"padj":0.98354,"ES":0.45353,"NES":0.57577,"nMoreExtreme":50599,"size":10,"leadingEdge":["CCT4","TCP1","DKC1","CCT7","WRAP53","CCT6A","CCT5","CCT8","CCT3","CCT2"]} {"pathway":"GO_NOREPINEPHRINE_SECRETION","pval":0.91466,"padj":0.98699,"ES":0.45446,"NES":0.57549,"nMoreExtreme":52226,"size":11,"leadingEdge":["AGT","P2RY12","ADORA2A"]} {"pathway":"GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME_TELOMERIC_REGION","pval":0.94379,"padj":0.9896,"ES":0.45361,"NES":0.5748,"nMoreExtreme":54966,"size":13,"leadingEdge":["CCT4","TCP1","GNL3L","DKC1","CCT7","WRAP53","CCT6A","TERF1","CCT5","CCT8","CCT3","GNL3","CCT2"]} {"pathway":"GO_CENTRIOLE_ELONGATION","pval":0.78122,"padj":0.96254,"ES":0.42978,"NES":0.57468,"nMoreExtreme":41927,"size":6,"leadingEdge":["VPS4B","CHMP2A","CENPJ","CEP295","C2CD3","CEP120"]} {"pathway":"GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME","pval":0.93078,"padj":0.98762,"ES":0.45358,"NES":0.57438,"nMoreExtreme":53689,"size":12,"leadingEdge":["CCT4","TCP1","DKC1","CCT7","WRAP53","CCT6A","TERF1","CCT5","CCT8","CCT3","SPIDR","CCT2"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_NUCLEOPLASM","pval":0.93078,"padj":0.98762,"ES":0.45358,"NES":0.57438,"nMoreExtreme":53689,"size":12,"leadingEdge":["NOP53","CCT4","TCP1","DKC1","CCT7","WRAP53","CCT6A","CCT5","TBRG1","CCT8","CCT3","CCT2"]} {"pathway":"GO_ARGININE_CATABOLIC_PROCESS","pval":0.87479,"padj":0.97837,"ES":0.44916,"NES":0.57371,"nMoreExtreme":48886,"size":9,"leadingEdge":["NOS2","ATP2B4","OAT","ARG2","NOS1","FAH"]} {"pathway":"GO_STRESS_GRANULE_DISASSEMBLY","pval":0.75619,"padj":0.9603,"ES":0.41689,"NES":0.57346,"nMoreExtreme":40012,"size":5,"leadingEdge":["ZFAND1","KLC1","DYRK3","VCP","KIF5B"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_MIGRATION","pval":0.91557,"padj":0.987,"ES":0.45285,"NES":0.57346,"nMoreExtreme":52278,"size":11,"leadingEdge":["PADI2","CCL2","RIPOR2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_B_CELL_RECEPTOR_SIGNALING_PATHWAY","pval":0.81616,"padj":0.971,"ES":0.4384,"NES":0.57346,"nMoreExtreme":44362,"size":7,"leadingEdge":["CD22","FCGR2B","LPXN","PTPN6","GPS2","PLCL2","CD300A"]} {"pathway":"GO_STEROID_HORMONE_SECRETION","pval":0.95353,"padj":0.9929,"ES":0.45031,"NES":0.57306,"nMoreExtreme":56125,"size":14,"leadingEdge":["AGT","NKX3-1","CRY1"]} {"pathway":"GO_DIRECT_OSSIFICATION","pval":0.78202,"padj":0.96269,"ES":0.42809,"NES":0.57243,"nMoreExtreme":41970,"size":6,"leadingEdge":["MMP2","COL1A1","CTSK","FGF18","AXIN2","MN1"]} {"pathway":"GO_HISTONE_H3_K27_DEMETHYLATION","pval":0.75504,"padj":0.9603,"ES":0.40113,"NES":0.57123,"nMoreExtreme":39296,"size":4,"leadingEdge":["KDM7A","KDM6B","KDM6A","PHF8"]} {"pathway":"GO_CONVERGENT_EXTENSION","pval":0.95423,"padj":0.9932,"ES":0.44835,"NES":0.57057,"nMoreExtreme":56166,"size":14,"leadingEdge":["DVL2","LRP6","SFRP1","DVL1","PTK7","NPHP3","WNT5A","MKKS","TRIM28","NKD1","SFRP2","VANGL2","FRZB","MESP1"]} {"pathway":"GO_DETERMINATION_OF_LEFT_RIGHT_ASYMMETRY_IN_LATERAL_MESODERM","pval":0.80521,"padj":0.96696,"ES":0.38628,"NES":0.56911,"nMoreExtreme":41163,"size":3,"leadingEdge":["SMO","CITED2","SMAD2"]} {"pathway":"GO_PHOSPHATIDYLGLYCEROL_BIOSYNTHETIC_PROCESS","pval":0.84844,"padj":0.97602,"ES":0.44085,"NES":0.56901,"nMoreExtreme":46749,"size":8,"leadingEdge":["PGS1","CRLS1","CDS2","TAZ","PTPMT1","SLC27A1","TAMM41"]} {"pathway":"GO_MAINTENANCE_OF_ANIMAL_ORGAN_IDENTITY","pval":0.75748,"padj":0.9603,"ES":0.39951,"NES":0.56891,"nMoreExtreme":39423,"size":4,"leadingEdge":["PKP2","NPHP3","ADGRV1","IQCB1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_AMINE_TRANSPORT","pval":0.94579,"padj":0.9905,"ES":0.44868,"NES":0.56856,"nMoreExtreme":55083,"size":13,"leadingEdge":["P2RY12","RGS2"]} {"pathway":"GO_TRICARBOXYLIC_ACID_METABOLIC_PROCESS","pval":0.89852,"padj":0.98385,"ES":0.4463,"NES":0.5666,"nMoreExtreme":50717,"size":10,"leadingEdge":["IDH3G","SIRT4","ACO2","IDH3B","ACO1","ACLY","IREB2","IDH1","GLUD1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELLULAR_AMINE_METABOLIC_PROCESS","pval":0.78416,"padj":0.96311,"ES":0.42337,"NES":0.56612,"nMoreExtreme":42085,"size":6,"leadingEdge":["ATP2B4","COMT","SNCA","ITGB2","ATCAY","ITGAM"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_TESTOSTERONE_STIMULUS","pval":0.8764,"padj":0.9791,"ES":0.44275,"NES":0.56552,"nMoreExtreme":48976,"size":9,"leadingEdge":["AACS","SIRT1","RWDD1","SPP1","ELK1","ROCK2","SRD5A1","MSN"]} {"pathway":"GO_S_ADENOSYLMETHIONINE_CYCLE","pval":0.81798,"padj":0.97133,"ES":0.43171,"NES":0.56471,"nMoreExtreme":44461,"size":7,"leadingEdge":["MRI1","AHCY","MTRR","ENOPH1","APIP","AHCYL2","AHCYL1"]} {"pathway":"GO_HISTONE_H3_K14_ACETYLATION","pval":0.81814,"padj":0.97133,"ES":0.4312,"NES":0.56405,"nMoreExtreme":44470,"size":7,"leadingEdge":["GATA3","SIRT1"]} {"pathway":"GO_RNA_IMPORT_INTO_MITOCHONDRION","pval":0.7614,"padj":0.96082,"ES":0.39597,"NES":0.56387,"nMoreExtreme":39627,"size":4,"leadingEdge":["MRPL18","TST","PNPT1","TOMM20"]} {"pathway":"GO_AMINOACYL_TRNA_METABOLISM_INVOLVED_IN_TRANSLATIONAL_FIDELITY","pval":0.81822,"padj":0.97133,"ES":0.43049,"NES":0.56311,"nMoreExtreme":44474,"size":7,"leadingEdge":["LARS2","IARS2","DTD1","DTD2","VARS2","TARS2"]} {"pathway":"GO_NUCLEAR_RETENTION_OF_PRE_MRNA_AT_THE_SITE_OF_TRANSCRIPTION","pval":0.76201,"padj":0.96082,"ES":0.40925,"NES":0.56295,"nMoreExtreme":40320,"size":5,"leadingEdge":["EXOSC3","PCID2","EXOSC2","PRPF18","EXOSC10"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_HOMODIMERIZATION_ACTIVITY","pval":0.89941,"padj":0.98394,"ES":0.4429,"NES":0.56227,"nMoreExtreme":50767,"size":10,"leadingEdge":["STPG1","TRAF4","MEF2C","CRBN","PARK7","TRAF2","GNL3L","LGALS3"]} {"pathway":"GO_MACROPHAGE_COLONY_STIMULATING_FACTOR_PRODUCTION","pval":0.76404,"padj":0.96082,"ES":0.39406,"NES":0.56115,"nMoreExtreme":39764,"size":4,"leadingEdge":["FOXP1","HAVCR2","TSLP","CD34"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NECROTIC_CELL_DEATH","pval":0.76333,"padj":0.96082,"ES":0.40772,"NES":0.56085,"nMoreExtreme":40390,"size":5,"leadingEdge":["HEBP2","TSPO","RIPK3","RIPK1"]} {"pathway":"GO_MITOCHONDRIAL_TRNA_METHYLATION","pval":0.76502,"padj":0.96082,"ES":0.39338,"NES":0.56019,"nMoreExtreme":39815,"size":4,"leadingEdge":["HSD17B10","TRMT5","TRMT61B","TRMT10C"]} {"pathway":"GO_REGULATION_OF_RIBONUCLEOPROTEIN_COMPLEX_LOCALIZATION","pval":0.78679,"padj":0.96311,"ES":0.41818,"NES":0.55918,"nMoreExtreme":42226,"size":6,"leadingEdge":["AKAP8L","ZC3H3","RIOK2","SUPT6H"]} {"pathway":"GO_DISRUPTION_BY_HOST_OF_SYMBIONT_CELLS","pval":0.76464,"padj":0.96082,"ES":0.40638,"NES":0.55901,"nMoreExtreme":40459,"size":5,"leadingEdge":["GAPDH","TUSC2","CXCL6","F2RL1","AZU1"]} {"pathway":"GO_VENTRICULAR_TRABECULA_MYOCARDIUM_MORPHOGENESIS","pval":0.94797,"padj":0.99093,"ES":0.44067,"NES":0.5584,"nMoreExtreme":55210,"size":13,"leadingEdge":["HEG1","TGFB2"]} {"pathway":"GO_NEPHRIC_DUCT_DEVELOPMENT","pval":0.94801,"padj":0.99093,"ES":0.44053,"NES":0.55823,"nMoreExtreme":55212,"size":13,"leadingEdge":["GATA3","HNF1B","PKD1"]} {"pathway":"GO_REGULATION_OF_AXON_DIAMETER","pval":0.87678,"padj":0.97923,"ES":0.37357,"NES":0.5572,"nMoreExtreme":44060,"size":2,"leadingEdge":["XK"]} {"pathway":"GO_NUCLEAR_MEMBRANE_ORGANIZATION","pval":0.78776,"padj":0.96334,"ES":0.41612,"NES":0.55643,"nMoreExtreme":42278,"size":6,"leadingEdge":["TARDBP","TOR1B","TOR1A","TOR1AIP1","GPER1","TMEM43"]} {"pathway":"GO_CARDIAC_LEFT_VENTRICLE_MORPHOGENESIS","pval":0.87787,"padj":0.97973,"ES":0.43513,"NES":0.55579,"nMoreExtreme":49058,"size":9,"leadingEdge":["FOXF1","GSK3A","CPE","HAND1","SMAD4","SFRP2","NOTCH1","TGFBR2","RBPJ"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CARDIOBLAST_DIFFERENTIATION","pval":0.77061,"padj":0.96084,"ES":0.38906,"NES":0.55403,"nMoreExtreme":40106,"size":4,"leadingEdge":["TGFB2","GATA4","GATA6","DHX36"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TRANSMISSION_OF_NERVE_IMPULSE","pval":0.82436,"padj":0.97439,"ES":0.37471,"NES":0.55206,"nMoreExtreme":42142,"size":3,"leadingEdge":["TNR","ITGA2","GBA"]} {"pathway":"GO_OLFACTORY_BEHAVIOR","pval":0.78923,"padj":0.96429,"ES":0.41281,"NES":0.552,"nMoreExtreme":42357,"size":6,"leadingEdge":["CFAP69","WFS1","ADCY3","UBR3","SHANK1","CHD7"]} {"pathway":"GO_HISTONE_H3_K27_TRIMETHYLATION","pval":0.88363,"padj":0.98086,"ES":0.37003,"NES":0.55192,"nMoreExtreme":44404,"size":2,"leadingEdge":["EZH2","BEND3"]} {"pathway":"GO_REGULATION_OF_AMYLOID_FIBRIL_FORMATION","pval":0.78932,"padj":0.96429,"ES":0.41249,"NES":0.55157,"nMoreExtreme":42362,"size":6,"leadingEdge":["PSEN1","CLU","LDLR","APOE","APP"]} {"pathway":"GO_ISOCITRATE_METABOLIC_PROCESS","pval":0.76965,"padj":0.96082,"ES":0.4003,"NES":0.55065,"nMoreExtreme":40724,"size":5,"leadingEdge":["IDH3G","ACO2","IDH3B","IDH1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME","pval":0.97389,"padj":0.99809,"ES":0.42773,"NES":0.54948,"nMoreExtreme":58338,"size":16,"leadingEdge":["THRAP3","DAZAP1","CIRBP","SNW1","CELF4","RBM3","SNRNP70","PRPF19","NUP98","PRDX6","TRA2B","NCBP1","SF3B4","RBMX"]} {"pathway":"GO_REGULATION_OF_BASEMENT_MEMBRANE_ASSEMBLY_INVOLVED_IN_EMBRYONIC_BODY_MORPHOGENESIS","pval":0.77136,"padj":0.96084,"ES":0.39846,"NES":0.54811,"nMoreExtreme":40815,"size":5,"leadingEdge":["PHLDB1","CLASP1","PHLDB2","CLASP2","DAG1"]} {"pathway":"GO_REDUCTION_OF_FOOD_INTAKE_IN_RESPONSE_TO_DIETARY_EXCESS","pval":0.88852,"padj":0.98088,"ES":0.36745,"NES":0.54807,"nMoreExtreme":44650,"size":2,"leadingEdge":["GDF15","RMI1"]} {"pathway":"GO_REGULATION_OF_LYSOSOME_ORGANIZATION","pval":0.77178,"padj":0.96084,"ES":0.39794,"NES":0.5474,"nMoreExtreme":40837,"size":5,"leadingEdge":["GRN","LAPTM4B","BECN1","SCARB2"]} {"pathway":"GO_SEBACEOUS_GLAND_DEVELOPMENT","pval":0.77772,"padj":0.96098,"ES":0.38355,"NES":0.54619,"nMoreExtreme":40476,"size":4,"leadingEdge":["ASH1L","SMAD4","RBPJ","ZDHHC21"]} {"pathway":"GO_PROTEIN_UFMYLATION","pval":0.79158,"padj":0.96486,"ES":0.40816,"NES":0.54579,"nMoreExtreme":42483,"size":6,"leadingEdge":["UFL1","UBA5","CDK5RAP3","UFM1","UFC1"]} {"pathway":"GO_SIALIC_ACID_TRANSPORT","pval":0.77848,"padj":0.96098,"ES":0.38288,"NES":0.54523,"nMoreExtreme":40516,"size":4,"leadingEdge":["SLC17A5","SLC35A5","SLC35A1","SLC35A4"]} {"pathway":"GO_EIF2ALPHA_PHOSPHORYLATION_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS","pval":0.79204,"padj":0.96486,"ES":0.40725,"NES":0.54456,"nMoreExtreme":42508,"size":6,"leadingEdge":["NCK2","DNAJC3","EIF2AK4","NCK1","PPP1R15B","EIF2AK3"]} {"pathway":"GO_REGULATION_OF_PLASMA_MEMBRANE_ORGANIZATION","pval":0.90175,"padj":0.98417,"ES":0.42886,"NES":0.54445,"nMoreExtreme":50899,"size":10,"leadingEdge":["DNM2","TGFB2","SH3GLB1","WASL","SH3GL2","PLEKHM2","GSN","ASAP1","PRKCD","AR"]} {"pathway":"GO_LENS_FIBER_CELL_DEVELOPMENT","pval":0.87938,"padj":0.98004,"ES":0.42615,"NES":0.54432,"nMoreExtreme":49142,"size":9,"leadingEdge":["PROX1","VIM"]} {"pathway":"GO_PEPTIDYL_DIPHTHAMIDE_BIOSYNTHETIC_PROCESS_FROM_PEPTIDYL_HISTIDINE","pval":0.82239,"padj":0.9738,"ES":0.41559,"NES":0.54362,"nMoreExtreme":44701,"size":7,"leadingEdge":["DPH1","DPH5","DPH2","DPH6","DPH7","DPH3","DNAJC24"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_EXTRACELLULAR_REGION","pval":0.77492,"padj":0.96098,"ES":0.39442,"NES":0.54255,"nMoreExtreme":41003,"size":5,"leadingEdge":["LTBP1","FBN2","NBL1","FBN1","NRROS"]} {"pathway":"GO_PURINE_NUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS","pval":0.92068,"padj":0.987,"ES":0.42817,"NES":0.5422,"nMoreExtreme":52570,"size":11,"leadingEdge":["BAD","DLG1","MAGI3","TJP2","MPP1","AMPD3","CASK","DLG2","AK9","LRGUK"]} {"pathway":"GO_MITOCHONDRIAL_RNA_3_END_PROCESSING","pval":0.77601,"padj":0.96098,"ES":0.3934,"NES":0.54116,"nMoreExtreme":41061,"size":5,"leadingEdge":["HSD17B10","TRNT1","PNPT1","SUPV3L1","TRMT10C"]} {"pathway":"GO_TRNA_THIO_MODIFICATION","pval":0.77607,"padj":0.96098,"ES":0.39335,"NES":0.54108,"nMoreExtreme":41064,"size":5,"leadingEdge":["TRMU","MOCS3","CTU1","URM1","CTU2"]} {"pathway":"GO_SKELETAL_MUSCLE_SATELLITE_CELL_DIFFERENTIATION","pval":0.77779,"padj":0.96098,"ES":0.39144,"NES":0.53845,"nMoreExtreme":41155,"size":5,"leadingEdge":["CDON","SIX4","MEGF10","EPHB1","AKIRIN1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SKELETAL_MUSCLE_CELL_DIFFERENTIATION","pval":0.77779,"padj":0.96098,"ES":0.39144,"NES":0.53845,"nMoreExtreme":41155,"size":5,"leadingEdge":["SIX4","MYOCD","EPHB1","S100B","AKIRIN1"]} {"pathway":"GO_ANTEROGRADE_AXONAL_PROTEIN_TRANSPORT","pval":0.85331,"padj":0.97645,"ES":0.41696,"NES":0.53817,"nMoreExtreme":47017,"size":8,"leadingEdge":["RAB27B","HSPB1","TERF2","MAPK8IP3","DLG2","MAP1A","KIF5C","KIF5B"]} {"pathway":"GO_TRACHEA_CARTILAGE_DEVELOPMENT","pval":0.79469,"padj":0.96602,"ES":0.40219,"NES":0.5378,"nMoreExtreme":42650,"size":6,"leadingEdge":["LRP6","SRF","SOX9","RARA","RSPO2","RARG"]} {"pathway":"GO_RESPONSE_TO_ISOLATION_STRESS","pval":0.77883,"padj":0.96098,"ES":0.39037,"NES":0.53699,"nMoreExtreme":41210,"size":5,"leadingEdge":["LGALS1","ACO2","KRAS","NAPEPLD","HRAS"]} {"pathway":"GO_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT","pval":0.97441,"padj":0.9981,"ES":0.41766,"NES":0.53655,"nMoreExtreme":58369,"size":16,"leadingEdge":["AKAP8L","ZC3H3","TPR","RIOK2","RBM27","SUPT6H","CPSF6","NCBP2","KHDRBS1","NUP153","DHX9","RIPK1","RBM26","IWS1","ADORA1"]} {"pathway":"GO_MITOCHONDRIAL_RNA_CATABOLIC_PROCESS","pval":0.77936,"padj":0.96107,"ES":0.38987,"NES":0.53629,"nMoreExtreme":41238,"size":5,"leadingEdge":["SLIRP","PNPT1","LRPPRC","SUPV3L1","PDE12"]} {"pathway":"GO_GLYCEROL_BIOSYNTHETIC_PROCESS","pval":0.84271,"padj":0.97458,"ES":0.36368,"NES":0.53581,"nMoreExtreme":43080,"size":3,"leadingEdge":["PCK2","GOT1"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_BASOLATERAL_PLASMA_MEMBRANE","pval":0.82431,"padj":0.97439,"ES":0.40961,"NES":0.5358,"nMoreExtreme":44805,"size":7,"leadingEdge":["RAB10","LIN7B","CAV1","LIN7A","PDZD11"]} {"pathway":"GO_RNA_GUANINE_N7_METHYLATION","pval":0.79592,"padj":0.96646,"ES":0.40039,"NES":0.5354,"nMoreExtreme":42716,"size":6,"leadingEdge":["METTL1","BUD23","RNMT","WDR4","RAMAC","TRMT112"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_ELECTRICAL_STIMULUS","pval":0.82455,"padj":0.97439,"ES":0.4089,"NES":0.53487,"nMoreExtreme":44818,"size":7,"leadingEdge":["REST","SLC9A1","PALM","GRM1","NSMF","NEUROD2","PTEN"]} {"pathway":"GO_SPERM_EJACULATION","pval":0.90536,"padj":0.98417,"ES":0.35835,"NES":0.5345,"nMoreExtreme":45496,"size":2,"leadingEdge":["ACVR2A","OXTR"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_PRESYNAPSE","pval":0.88052,"padj":0.98072,"ES":0.41698,"NES":0.53261,"nMoreExtreme":49206,"size":9,"leadingEdge":["RAB27B","HSPB1","DVL1","TERF2","MAPK8IP3","DLG2","MAP1A","KIF5C","KIF5B"]} {"pathway":"GO_ODONTOBLAST_DIFFERENTIATION","pval":0.79044,"padj":0.96481,"ES":0.374,"NES":0.5326,"nMoreExtreme":41138,"size":4,"leadingEdge":["SERPINE1","LEF1","CEBPB","FAM20C"]} {"pathway":"GO_POSITIVE_REGULATION_OF_FEAR_RESPONSE","pval":0.90789,"padj":0.98435,"ES":0.35689,"NES":0.53232,"nMoreExtreme":45623,"size":2,"leadingEdge":["MEF2C","PENK"]} {"pathway":"GO_GMP_METABOLIC_PROCESS","pval":0.90253,"padj":0.98417,"ES":0.41905,"NES":0.532,"nMoreExtreme":50943,"size":10,"leadingEdge":["DLG1","MAGI3","GMPR2","TJP2","MPP1","GUK1","CASK","DLG2","LRGUK"]} {"pathway":"GO_REGULATION_OF_TRANSLATIONAL_ELONGATION","pval":0.96757,"padj":0.99587,"ES":0.41577,"NES":0.53121,"nMoreExtreme":57495,"size":15,"leadingEdge":["ALKBH1","CPEB3","DPH1","DPH5","EIF5A","DPH2","DPH6","CPEB2","EIF4A3","SRP9","DPH7","DPH3","USP16","EIF5A2","DNAJC24"]} {"pathway":"GO_CYTOPLASMIC_TRANSLATIONAL_ELONGATION","pval":0.88068,"padj":0.98075,"ES":0.41563,"NES":0.53089,"nMoreExtreme":49215,"size":9,"leadingEdge":["CPEB3","DPH1","DPH5","DPH2","DPH6","CPEB2","DPH7","DPH3","DNAJC24"]} {"pathway":"GO_REGULATION_OF_MICROVILLUS_LENGTH","pval":0.84899,"padj":0.9761,"ES":0.36031,"NES":0.53085,"nMoreExtreme":43401,"size":3,"leadingEdge":["EZR","PLS1"]} {"pathway":"GO_CELL_MIGRATION_INVOLVED_IN_VASCULOGENESIS","pval":0.90998,"padj":0.98498,"ES":0.35576,"NES":0.53064,"nMoreExtreme":45728,"size":2,"leadingEdge":["PDGFRB","SETD2"]} {"pathway":"GO_RNA_POLYMERASE_III_PREINITIATION_COMPLEX_ASSEMBLY","pval":0.826,"padj":0.97439,"ES":0.40515,"NES":0.52997,"nMoreExtreme":44897,"size":7,"leadingEdge":["TBPL1","BRF2","TBP","GTF3C3","BDP1","GTF3C5"]} {"pathway":"GO_MYELOID_PROGENITOR_CELL_DIFFERENTIATION","pval":0.7932,"padj":0.96517,"ES":0.37204,"NES":0.5298,"nMoreExtreme":41282,"size":4,"leadingEdge":["DPF2","BRAF","JAM3","MLF1"]} {"pathway":"GO_MITOCHONDRIAL_PROTON_TRANSPORTING_ATP_SYNTHASE_COMPLEX_ASSEMBLY","pval":0.78437,"padj":0.96311,"ES":0.38475,"NES":0.52926,"nMoreExtreme":41503,"size":5,"leadingEdge":["ATPAF1","OXA1L","FMC1","ATP23","TMEM70"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_OXIDATIVE_PHOSPHORYLATION","pval":0.79925,"padj":0.96646,"ES":0.39496,"NES":0.52813,"nMoreExtreme":42895,"size":6,"leadingEdge":["MLXIPL","RHOA","PPIF","DNAJC15","SNCA"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE","pval":0.82662,"padj":0.97439,"ES":0.40367,"NES":0.52804,"nMoreExtreme":44931,"size":7,"leadingEdge":["PIAS4","FBH1","SKIL","NACC2","RPS3","RPL26","RAD9A"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TRANSLATION_IN_RESPONSE_TO_STRESS","pval":0.79937,"padj":0.96646,"ES":0.39478,"NES":0.52788,"nMoreExtreme":42901,"size":6,"leadingEdge":["ATF4","EIF2AK4","SESN2","EIF2S1","EIF2AK3","RBM4"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA1_PRODUCTION","pval":0.78578,"padj":0.96311,"ES":0.38317,"NES":0.52708,"nMoreExtreme":41578,"size":5,"leadingEdge":["TYROBP","LAPTM4B","FURIN","GATA6"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_HYPOXIA","pval":0.79989,"padj":0.96646,"ES":0.3941,"NES":0.52698,"nMoreExtreme":42929,"size":6,"leadingEdge":["ENO1","TMBIM6","HYOU1","DDAH1","PINK1","CD34"]} {"pathway":"GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_HYPOXIA","pval":0.78656,"padj":0.96311,"ES":0.38228,"NES":0.52586,"nMoreExtreme":41619,"size":5,"leadingEdge":["ENO1","TMBIM6","HYOU1","PINK1","BNIP3"]} {"pathway":"GO_ENUCLEATE_ERYTHROCYTE_DIFFERENTIATION","pval":0.8271,"padj":0.97439,"ES":0.40193,"NES":0.52576,"nMoreExtreme":44957,"size":7,"leadingEdge":["MAEA","ID2","MED1","RB1","CEBPG","TRIM58","SP3"]} {"pathway":"GO_REGULATION_OF_TRANSLATION_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS","pval":0.85548,"padj":0.97645,"ES":0.40729,"NES":0.5257,"nMoreExtreme":47137,"size":8,"leadingEdge":["NCK2","PPP1R15A","DNAJC3","EIF2AK4","SESN2","NCK1","PPP1R15B","EIF2AK3"]} {"pathway":"GO_ADENYLATE_CYCLASE_ACTIVATING_ADRENERGIC_RECEPTOR_SIGNALING_PATHWAY_INVOLVED_IN_HEART_PROCESS","pval":0.80045,"padj":0.96646,"ES":0.39307,"NES":0.52561,"nMoreExtreme":42959,"size":6,"leadingEdge":["ATP2B4","NOS1","PDE4D","GNAI2"]} {"pathway":"GO_DE_NOVO_PYRIMIDINE_NUCLEOBASE_BIOSYNTHETIC_PROCESS","pval":0.80099,"padj":0.96646,"ES":0.39223,"NES":0.52448,"nMoreExtreme":42988,"size":6,"leadingEdge":["CPS1","CAD","DHODH","UMPS"]} {"pathway":"GO_INSEMINATION","pval":0.79856,"padj":0.96646,"ES":0.3683,"NES":0.52448,"nMoreExtreme":41561,"size":4,"leadingEdge":["P2RX1","ACVR2A","SERPINE2"]} {"pathway":"GO_STEROL_IMPORT","pval":0.85601,"padj":0.97645,"ES":0.40533,"NES":0.52316,"nMoreExtreme":47166,"size":8,"leadingEdge":["SCARB1","APOA1","LRP1","LDLR","CD36","LAMTOR1","STARD4","STARD5"]} {"pathway":"GO_POSITIVE_REGULATION_OF_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY","pval":0.80201,"padj":0.96646,"ES":0.39067,"NES":0.5224,"nMoreExtreme":43043,"size":6,"leadingEdge":["PRKD2","SMOC2","DSTYK","NPTN","CTNNB1","FGFBP3"]} {"pathway":"GO_REGULATION_OF_DENDRITIC_SPINE_MAINTENANCE","pval":0.88125,"padj":0.98086,"ES":0.40878,"NES":0.52213,"nMoreExtreme":49247,"size":9,"leadingEdge":["FYN","VPS35","FCGR2B","ZMYND8","ABHD17B","APOE","HOMER1","ZNF804A","PRNP"]} {"pathway":"GO_PROLINE_BIOSYNTHETIC_PROCESS","pval":0.78962,"padj":0.96445,"ES":0.37923,"NES":0.52165,"nMoreExtreme":41781,"size":5,"leadingEdge":["ALDH18A1","OAT","PYCR3"]} {"pathway":"GO_REGULATION_OF_RNA_BINDING","pval":0.93717,"padj":0.98783,"ES":0.41173,"NES":0.52138,"nMoreExtreme":54058,"size":12,"leadingEdge":["NUCKS1","EIF3D","FMR1","EIF3E","HNRNPL","EIF4G1","CDK9","NCBP1","EIF4A3","CARM1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SYNAPTIC_VESICLE_TRANSPORT","pval":0.80246,"padj":0.96646,"ES":0.38972,"NES":0.52112,"nMoreExtreme":43067,"size":6,"leadingEdge":["FMR1","RAP1A","RAP1B","SYT4","BRAF","CNIH2"]} {"pathway":"GO_PEPTIDYL_LYSINE_HYDROXYLATION","pval":0.85626,"padj":0.97645,"ES":0.40371,"NES":0.52107,"nMoreExtreme":47180,"size":8,"leadingEdge":["JMJD6","PLOD1","PLOD3","P3H3","P3H4","VIPAS39","PLOD2"]} {"pathway":"GO_N_TERMINAL_PEPTIDYL_METHIONINE_ACETYLATION","pval":0.82889,"padj":0.97439,"ES":0.39834,"NES":0.52106,"nMoreExtreme":45054,"size":7,"leadingEdge":["NAA25","NAA60","NAA35","NAA30","NAA15","NAA16","NAA20"]} {"pathway":"GO_REGULATION_OF_PROTEIN_FOLDING","pval":0.90309,"padj":0.98417,"ES":0.41014,"NES":0.52068,"nMoreExtreme":50975,"size":10,"leadingEdge":["GRN","HSPA5","ST13","SNRNP70","SGTA","PDCD5","DNAJB2","PDCL"]} {"pathway":"GO_TELOMERASE_HOLOENZYME_COMPLEX_ASSEMBLY","pval":0.80309,"padj":0.96646,"ES":0.38876,"NES":0.51985,"nMoreExtreme":43101,"size":6,"leadingEdge":["HSP90AA1","HSP90AB1","PTGES3","NAF1","ATM","ATR"]} {"pathway":"GO_TRNA_PSEUDOURIDINE_SYNTHESIS","pval":0.79187,"padj":0.96486,"ES":0.37711,"NES":0.51875,"nMoreExtreme":41900,"size":5,"leadingEdge":["PUS7","PUS3","PUS10","PUSL1","PUS1"]} {"pathway":"GO_MRNA_PSEUDOURIDINE_SYNTHESIS","pval":0.79187,"padj":0.96486,"ES":0.37711,"NES":0.51875,"nMoreExtreme":41900,"size":5,"leadingEdge":["PUS7","PUS3","DKC1","TRUB1","PUS1"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_NITROSATIVE_STRESS","pval":0.80397,"padj":0.96671,"ES":0.3877,"NES":0.51842,"nMoreExtreme":43148,"size":6,"leadingEdge":["ATG5","DNAJA1","PARK7","ATM","STOX1","DDIT3"]} {"pathway":"GO_REGULATION_OF_CILIUM_BEAT_FREQUENCY_INVOLVED_IN_CILIARY_MOTILITY","pval":0.80447,"padj":0.96671,"ES":0.38691,"NES":0.51737,"nMoreExtreme":43175,"size":6,"leadingEdge":["CFAP20","BBS2","MKKS","BBS4","CCSAP","CATSPER1"]} {"pathway":"GO_PROTEIN_INSERTION_INTO_ER_MEMBRANE","pval":0.7931,"padj":0.96517,"ES":0.37602,"NES":0.51725,"nMoreExtreme":41965,"size":5,"leadingEdge":["TRAM2","UBL4A","SGTA"]} {"pathway":"GO_U4_SNRNA_3_END_PROCESSING","pval":0.85701,"padj":0.97645,"ES":0.40058,"NES":0.51703,"nMoreExtreme":47221,"size":8,"leadingEdge":["EXOSC7","EXOSC5","EXOSC3","EXOSC8","EXOSC9","EXOSC2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MHC_CLASS_II_BIOSYNTHETIC_PROCESS","pval":0.80696,"padj":0.96769,"ES":0.36296,"NES":0.51688,"nMoreExtreme":41998,"size":4,"leadingEdge":["SPI1","NFX1","IL10"]} {"pathway":"GO_PROTEIN_POLYUFMYLATION","pval":0.79433,"padj":0.96574,"ES":0.3748,"NES":0.51557,"nMoreExtreme":42030,"size":5,"leadingEdge":["UFL1","UBA5","UFM1","UFC1"]} {"pathway":"GO_EXTRACELLULAR_EXOSOME_ASSEMBLY","pval":0.83075,"padj":0.97439,"ES":0.39412,"NES":0.51554,"nMoreExtreme":45155,"size":7,"leadingEdge":["TSG101","SDC1","SDC4","STAM","SDCBP","PDCD6IP","CD34"]} {"pathway":"GO_QUINONE_BIOSYNTHETIC_PROCESS","pval":0.97464,"padj":0.99814,"ES":0.40073,"NES":0.5148,"nMoreExtreme":58383,"size":16,"leadingEdge":["COQ9","COQ5","COQ10B","COQ6","UBIAD1","COQ8B","COQ3","COQ10A","NDUFA9","PDSS1","FDXR","COQ8A","PDSS2","COQ4","COQ7","COQ2"]} {"pathway":"GO_REGULATION_OF_MICROTUBULE_DEPOLYMERIZATION","pval":0.99812,"padj":1,"ES":0.37263,"NES":0.51472,"nMoreExtreme":64178,"size":27,"leadingEdge":["SPAST","NAV3","CLASP1","CAMSAP3","HDAC6","MID1","STMN2","TRPV4","APC2","ARHGEF2","CAMSAP2","TTBK2","FGF13","MAP1S","CAMSAP1","MAP1B","APC","CKAP2","KATNB1","TAOK1","CLASP2","MID1IP1","HDGFL3","BMERB1","MAP1A"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INTRACELLULAR_LIPID_TRANSPORT","pval":0.86655,"padj":0.97662,"ES":0.34927,"NES":0.51457,"nMoreExtreme":44299,"size":3,"leadingEdge":["SCP2","LDLRAP1","ANXA2"]} {"pathway":"GO_PROTON_TRANSPORTING_ATP_SYNTHASE_COMPLEX_ASSEMBLY","pval":0.80583,"padj":0.96708,"ES":0.38478,"NES":0.51451,"nMoreExtreme":43248,"size":6,"leadingEdge":["ATPAF1","OXA1L","FMC1","ATP23","ATPAF2","TMEM70"]} {"pathway":"GO_BASEMENT_MEMBRANE_ASSEMBLY","pval":0.85744,"padj":0.97645,"ES":0.39853,"NES":0.51439,"nMoreExtreme":47245,"size":8,"leadingEdge":["PHLDB1","LAMC2","CLASP1","PLOD3","RAMP2","PHLDB2","CLASP2","DAG1"]} {"pathway":"GO_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_EXECUTION_PHASE_OF_APOPTOSIS","pval":0.81009,"padj":0.96941,"ES":0.36075,"NES":0.51372,"nMoreExtreme":42161,"size":4,"leadingEdge":["RFFL","RPS3","RNF34","PAK2"]} {"pathway":"GO_SNORNA_PROCESSING","pval":0.92198,"padj":0.987,"ES":0.40554,"NES":0.51354,"nMoreExtreme":52644,"size":11,"leadingEdge":["EXOSC5","FBL","EXOSC3","TENT4A","TENT4B","RNF113A","EXOSC2","DKC1","PARN"]} {"pathway":"GO_PERIPHERAL_NERVOUS_SYSTEM_AXON_REGENERATION","pval":0.79676,"padj":0.96646,"ES":0.37266,"NES":0.51263,"nMoreExtreme":42159,"size":5,"leadingEdge":["TNC","TSPO","APOA1","CERS2"]} {"pathway":"GO_PEROXISOMAL_MEMBRANE_TRANSPORT","pval":0.97963,"padj":0.99901,"ES":0.39623,"NES":0.51242,"nMoreExtreme":59198,"size":17,"leadingEdge":["PEX3","ABCD1","LONP2","PEX12","PEX7","ABCD3","PEX16","PEX6","PEX1","PEX5","PEX14","PEX10","PEX19","PEX13","PEX2","RAB8B"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CENTROSOME","pval":0.83207,"padj":0.97439,"ES":0.39105,"NES":0.51152,"nMoreExtreme":45227,"size":7,"leadingEdge":["MARK4","GSK3B","PARD6A","CEP250","APC","BICD1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_RIBOSOME_BIOGENESIS","pval":0.88256,"padj":0.98086,"ES":0.40046,"NES":0.51151,"nMoreExtreme":49320,"size":9,"leadingEdge":["RIOK2","BUD23","DIMT1","WDR75","HEATR1","RIOK1","WDR43","UTP15","TRMT112"]} {"pathway":"GO_HISTONE_H3_K36_DEMETHYLATION","pval":0.88256,"padj":0.98086,"ES":0.40035,"NES":0.51137,"nMoreExtreme":49320,"size":9,"leadingEdge":["KDM7A","KDM4A","KDM2B","KDM4C","KDM4B","KDM8","RIOX1","PHF8","KDM2A"]} {"pathway":"GO_REGULATION_OF_MIRNA_METABOLIC_PROCESS","pval":0.83224,"padj":0.97439,"ES":0.39042,"NES":0.51069,"nMoreExtreme":45236,"size":7,"leadingEdge":["RC3H2","KHSRP","NFKB1","DROSHA","RC3H1","RELA","HRAS"]} {"pathway":"GO_REGULATION_OF_OOCYTE_MATURATION","pval":0.79845,"padj":0.96646,"ES":0.37119,"NES":0.5106,"nMoreExtreme":42248,"size":5,"leadingEdge":["SIRT2","AURKA","PPP2R1A"]} {"pathway":"GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_TELOMERE","pval":0.97963,"padj":0.99901,"ES":0.39483,"NES":0.5106,"nMoreExtreme":59198,"size":17,"leadingEdge":["ACD","CCT4","TCP1","POT1","DKC1","CCT7","NABP2","BRCA2","WRAP53","CCT6A","TERF1","ATM","CCT5","CCT8","CCT3","CCT2"]} {"pathway":"GO_GDP_METABOLIC_PROCESS","pval":0.85848,"padj":0.97645,"ES":0.39399,"NES":0.50853,"nMoreExtreme":47302,"size":8,"leadingEdge":["DLG1","MAGI3","TJP2","MPP1","CASK","DLG2","LRGUK"]} {"pathway":"GO_REGULATION_OF_FEAR_RESPONSE","pval":0.81664,"padj":0.971,"ES":0.35693,"NES":0.50828,"nMoreExtreme":42502,"size":4,"leadingEdge":["MEF2C","APOE","RAG1","PENK"]} {"pathway":"GO_TRNA_3_END_PROCESSING","pval":0.85864,"padj":0.97645,"ES":0.39347,"NES":0.50786,"nMoreExtreme":47311,"size":8,"leadingEdge":["ELAC2","HSD17B10","TRNT1","PTCD1","SSB","ELAC1","POLR3K","TRMT10C"]} {"pathway":"GO_DOLICHYL_DIPHOSPHATE_BIOSYNTHETIC_PROCESS","pval":0.83343,"padj":0.97443,"ES":0.38704,"NES":0.50628,"nMoreExtreme":45301,"size":7,"leadingEdge":["DHDDS","SRD5A3","NUS1","DOLPP1","MVD","DPAGT1","DOLK"]} {"pathway":"GO_SYNAPTIC_VESICLE_UNCOATING","pval":0.80234,"padj":0.96646,"ES":0.36768,"NES":0.50577,"nMoreExtreme":42454,"size":5,"leadingEdge":["SH3GL2","DNAJC6","SH3GL1","SYNJ1","GAK"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE","pval":0.85906,"padj":0.97645,"ES":0.39156,"NES":0.50539,"nMoreExtreme":47334,"size":8,"leadingEdge":["FCGR2B","GSTP1","ASH1L","SELENOS","PPARG","NLRP3","ADORA1","IL20RB"]} {"pathway":"GO_PROTEIN_FOLDING_IN_ENDOPLASMIC_RETICULUM","pval":0.96779,"padj":0.99587,"ES":0.39524,"NES":0.50498,"nMoreExtreme":57508,"size":15,"leadingEdge":["HSPA5","DNAJC10","ERO1B","SUCO","DNAJC3","EMC2","EMC3","CANX","EMC1","EMC6","EMC4"]} {"pathway":"GO_GLYCEROL_ETHER_BIOSYNTHETIC_PROCESS","pval":0.81034,"padj":0.96948,"ES":0.37757,"NES":0.50487,"nMoreExtreme":43490,"size":6,"leadingEdge":["AGPS","DHRS7B","PEX7","GNPAT"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE","pval":0.80342,"padj":0.96646,"ES":0.36683,"NES":0.50461,"nMoreExtreme":42511,"size":5,"leadingEdge":["SIRT2","BECN1","CCNB1","HNRNPU","RCC2"]} {"pathway":"GO_REGULATION_OF_ENDOPLASMIC_RETICULUM_TUBULAR_NETWORK_ORGANIZATION","pval":0.80347,"padj":0.96646,"ES":0.36677,"NES":0.50452,"nMoreExtreme":42514,"size":5,"leadingEdge":["TMEM33","RAB3GAP1","RAB3GAP2","LNPK"]} {"pathway":"GO_TRANSFORMING_GROWTH_FACTOR_BETA_ACTIVATION","pval":0.88369,"padj":0.98086,"ES":0.3945,"NES":0.5039,"nMoreExtreme":49383,"size":9,"leadingEdge":["LTBP1","HSP90AB1","ITGB8","ITGB6","LRRC32","ITGAV","FURIN","LTBP3","NRROS"]} {"pathway":"GO_POSITIVE_REGULATION_OF_B_CELL_DIFFERENTIATION","pval":0.92238,"padj":0.987,"ES":0.39595,"NES":0.5014,"nMoreExtreme":52667,"size":11,"leadingEdge":["BAD","BTK","PPP2R3C","XBP1","ATP11C","NCKAP1L","PCID2","MMP14","SYK","INPP5D","STAT5B"]} {"pathway":"GO_AMYLOID_FIBRIL_FORMATION","pval":0.95095,"padj":0.99259,"ES":0.39513,"NES":0.5007,"nMoreExtreme":55383,"size":13,"leadingEdge":["PSEN1","FKBP1A","CLU","RIPK3","LDLR","APOE","CD36","MDM2","RIPK1","APP","GSN"]} {"pathway":"GO_NUCLEOLUS_ORGANIZATION","pval":0.83549,"padj":0.97443,"ES":0.38202,"NES":0.49971,"nMoreExtreme":45413,"size":7,"leadingEdge":["RRN3","PES1","RPS19","POLR1B","EMG1"]} {"pathway":"GO_PEPTIDE_CROSS_LINKING_VIA_CHONDROITIN_4_SULFATE_GLYCOSAMINOGLYCAN","pval":0.8256,"padj":0.97439,"ES":0.35069,"NES":0.4994,"nMoreExtreme":42968,"size":4,"leadingEdge":["DCN","EGFLAM","NDNF","BGN"]} {"pathway":"GO_REGULATION_OF_CELLULAR_RESPONSE_TO_HYPOXIA","pval":0.92243,"padj":0.987,"ES":0.39421,"NES":0.4992,"nMoreExtreme":52670,"size":11,"leadingEdge":["ENO1","CHCHD2","RWDD3","AJUBA","ROCK2","TMBIM6","HYOU1","DDAH1","PINK1","USP19","CD34"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_LIPID_KINASE_ACTIVITY","pval":0.80803,"padj":0.96836,"ES":0.36261,"NES":0.4988,"nMoreExtreme":42755,"size":5,"leadingEdge":["PPP2R5A","PIK3IP1","DAB2IP","RUBCN"]} {"pathway":"GO_REGULATION_OF_LOW_DENSITY_LIPOPROTEIN_PARTICLE_RECEPTOR_CATABOLIC_PROCESS","pval":0.82781,"padj":0.97439,"ES":0.34929,"NES":0.4974,"nMoreExtreme":43083,"size":4,"leadingEdge":["MYLIP","APOE","FURIN","ANXA2"]} {"pathway":"GO_RECEPTOR_MEDIATED_ENDOCYTOSIS_INVOLVED_IN_CHOLESTEROL_TRANSPORT","pval":0.82781,"padj":0.97439,"ES":0.34929,"NES":0.4974,"nMoreExtreme":43083,"size":4,"leadingEdge":["LRP6","LDLR","LDLRAP1","ANXA2"]} {"pathway":"GO_REGULATION_OF_MIDBRAIN_DOPAMINERGIC_NEURON_DIFFERENTIATION","pval":0.8099,"padj":0.96941,"ES":0.36109,"NES":0.49671,"nMoreExtreme":42854,"size":5,"leadingEdge":["SFRP1","DKK1","CSNK1D","SFRP2"]} {"pathway":"GO_SULFUR_AMINO_ACID_CATABOLIC_PROCESS","pval":0.88483,"padj":0.98086,"ES":0.3888,"NES":0.49662,"nMoreExtreme":49447,"size":9,"leadingEdge":["TXN2","BLMH","CTH","MTRR","MPST","TST","GADL1","CBS"]} {"pathway":"GO_RESPONSE_TO_HYDROSTATIC_PRESSURE","pval":0.82906,"padj":0.97439,"ES":0.34833,"NES":0.49604,"nMoreExtreme":43148,"size":4,"leadingEdge":["ATP2B4","PKD2","KRT8","COL18A1"]} {"pathway":"GO_REGULATION_OF_METANEPHRIC_GLOMERULUS_DEVELOPMENT","pval":0.88703,"padj":0.98086,"ES":0.33652,"NES":0.49579,"nMoreExtreme":45346,"size":3,"leadingEdge":["EGR1","RET","WT1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_RNA_BINDING","pval":0.88496,"padj":0.98086,"ES":0.38799,"NES":0.49558,"nMoreExtreme":49454,"size":9,"leadingEdge":["EIF3D","FMR1","EIF3E","HNRNPL","EIF4G1","CDK9","NCBP1"]} {"pathway":"GO_MESENDODERM_DEVELOPMENT","pval":0.94639,"padj":0.99051,"ES":0.33167,"NES":0.4947,"nMoreExtreme":47558,"size":2,"leadingEdge":["BMPR1A","ZFP36L1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MEGAKARYOCYTE_DIFFERENTIATION","pval":0.88825,"padj":0.98088,"ES":0.33573,"NES":0.49463,"nMoreExtreme":45408,"size":3,"leadingEdge":["PRMT1","GABPA","CIB1"]} {"pathway":"GO_FATTY_ACID_BETA_OXIDATION_USING_ACYL_COA_DEHYDROGENASE","pval":0.90488,"padj":0.98417,"ES":0.38951,"NES":0.4945,"nMoreExtreme":51076,"size":10,"leadingEdge":["ACADVL","ETFB","GCDH","ACADM","ACADS","IVD","ETFBKMT","ETFA"]} {"pathway":"GO_REGULATION_OF_CONNECTIVE_TISSUE_REPLACEMENT","pval":0.83077,"padj":0.97439,"ES":0.34724,"NES":0.49448,"nMoreExtreme":43237,"size":4,"leadingEdge":["ROCK1","ROCK2","PPP3CA"]} {"pathway":"GO_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE_TRANSLOCATION","pval":0.92264,"padj":0.987,"ES":0.39045,"NES":0.49443,"nMoreExtreme":52682,"size":11,"leadingEdge":["SEC61A1","TRAM2","SEC61A2","TRAM1","SRP54","SEC61B","SRP9","SRP19","ZFAND2B","TRAM1L1","SRP72"]} {"pathway":"GO_N_TERMINAL_PROTEIN_LIPIDATION","pval":0.81264,"padj":0.97053,"ES":0.35897,"NES":0.49379,"nMoreExtreme":42999,"size":5,"leadingEdge":["PPM1A","NMT1","PPM1B","NMT2","MAP6D1"]} {"pathway":"GO_TRNA_TRANSCRIPTION","pval":0.8377,"padj":0.97458,"ES":0.37745,"NES":0.49374,"nMoreExtreme":45533,"size":7,"leadingEdge":["GTF3C1","GTF3C2","GTF3C3","GTF3C4","GTF3C5","GTF3C6"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELL_MIGRATION_BY_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_SIGNALING_PATHWAY","pval":0.83796,"padj":0.97458,"ES":0.37696,"NES":0.4931,"nMoreExtreme":45547,"size":7,"leadingEdge":["PRKD2","HSPB1","GAB1","VEGFA","KDR"]} {"pathway":"GO_CELLULAR_LIPID_BIOSYNTHETIC_PROCESS","pval":0.86174,"padj":0.97645,"ES":0.38176,"NES":0.49274,"nMoreExtreme":47482,"size":8,"leadingEdge":["AGPS","FDFT1","DHRS7B","PEX7","GNPAT","ERG28"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_AUTOPHAGY_OF_MITOCHONDRION","pval":0.86191,"padj":0.97645,"ES":0.38112,"NES":0.49192,"nMoreExtreme":47491,"size":8,"leadingEdge":["CLEC16A","TIGAR","TSPO","TSC2","HTRA2","USP30","PINK1"]} {"pathway":"GO_ADP_TRANSPORT","pval":0.81449,"padj":0.971,"ES":0.35751,"NES":0.49178,"nMoreExtreme":43097,"size":5,"leadingEdge":["SLC25A5","SLC25A17","SLC25A4","SLC25A6","SLC25A42"]} {"pathway":"GO_ACTIN_FILAMENT_REORGANIZATION","pval":0.86193,"padj":0.97645,"ES":0.38101,"NES":0.49178,"nMoreExtreme":47492,"size":8,"leadingEdge":["BCAR1","CASS4","EFS","NEDD9","GSN","WHAMM","DMTN"]} {"pathway":"GO_SNORNA_3_END_PROCESSING","pval":0.90513,"padj":0.98417,"ES":0.38732,"NES":0.49172,"nMoreExtreme":51090,"size":10,"leadingEdge":["EXOSC5","FBL","EXOSC3","TENT4A","TENT4B","EXOSC2","DKC1","PARN"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_NON_CANONICAL_WNT_SIGNALING_PATHWAY","pval":0.83572,"padj":0.97443,"ES":0.34434,"NES":0.49036,"nMoreExtreme":43495,"size":4,"leadingEdge":["IFT80","SFRP1","SFRP2","ZNRF3"]} {"pathway":"GO_SKIN_MORPHOGENESIS","pval":0.83902,"padj":0.97458,"ES":0.3748,"NES":0.49026,"nMoreExtreme":45605,"size":7,"leadingEdge":["PSEN1","COL1A1","SRF","ERRFI1","ITGA2","COL1A2","GBA"]} {"pathway":"GO_REGULATION_OF_MRNA_EXPORT_FROM_NUCLEUS","pval":0.81615,"padj":0.971,"ES":0.35582,"NES":0.48946,"nMoreExtreme":43185,"size":5,"leadingEdge":["AKAP8L","ZC3H3","SUPT6H","IWS1","SETD2"]} {"pathway":"GO_SNRNA_MODIFICATION","pval":0.8175,"padj":0.97133,"ES":0.35469,"NES":0.4879,"nMoreExtreme":43256,"size":5,"leadingEdge":["METTL16","DKC1","NHP2","MEPCE"]} {"pathway":"GO_ASYMMETRIC_STEM_CELL_DIVISION","pval":0.86291,"padj":0.97662,"ES":0.37794,"NES":0.48781,"nMoreExtreme":47546,"size":8,"leadingEdge":["TEAD3","RAB10","ARHGEF2","DOCK7","FGF13","SOX5"]} {"pathway":"GO_MITOCHONDRIAL_RNA_MODIFICATION","pval":0.86316,"padj":0.97662,"ES":0.37718,"NES":0.48683,"nMoreExtreme":47560,"size":8,"leadingEdge":["TRIT1","HSD17B10","CDK5RAP1","TRMT5","MTO1","TRMT61B","TRMT10C","PUS1"]} {"pathway":"GO_GLYOXYLATE_METABOLIC_PROCESS","pval":0.81852,"padj":0.97133,"ES":0.35363,"NES":0.48645,"nMoreExtreme":43310,"size":5,"leadingEdge":["GOT2","GRHPR","IDH1","ALDH4A1","IDH2"]} {"pathway":"GO_PROTEIN_IMPORT_INTO_PEROXISOME_MATRIX","pval":0.93818,"padj":0.98783,"ES":0.38357,"NES":0.48572,"nMoreExtreme":54116,"size":12,"leadingEdge":["LONP2","PEX12","PEX7","PEX16","PEX6","PEX1","PEX5","PEX14","PEX10","PEX13","PEX2"]} {"pathway":"GO_PEPTIDYL_SERINE_AUTOPHOSPHORYLATION","pval":0.84175,"padj":0.97458,"ES":0.3694,"NES":0.48321,"nMoreExtreme":45753,"size":7,"leadingEdge":["MARK3","MAP2K2","RIPK1","ATM","DYRK1A","PINK1","ERN1"]} {"pathway":"GO_AXIS_ELONGATION_INVOLVED_IN_SOMITOGENESIS","pval":0.84512,"padj":0.97458,"ES":0.33822,"NES":0.48164,"nMoreExtreme":43984,"size":4,"leadingEdge":["LRP6","SFRP1","NKD1","MED12"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME_TELOMERIC_REGION","pval":0.99753,"padj":1,"ES":0.35068,"NES":0.48147,"nMoreExtreme":63824,"size":26,"leadingEdge":["XRCC5","ATRX","ACD","TNKS2","CCT4","TCP1","POT1","GNL3L","DKC1","TERF2","CCT7","NABP2","BRCA2","WRAP53","CCT6A","TERF1","ATM","CCT5","CCT8","CCT3","GNL3","CCT2","TERF2IP","TNKS","ATR"]} {"pathway":"GO_VESICLE_UNCOATING","pval":0.84276,"padj":0.97458,"ES":0.36772,"NES":0.481,"nMoreExtreme":45808,"size":7,"leadingEdge":["SH3GL2","HSPA8","DNAJC6","VPS4A","SH3GL1","SYNJ1","GAK"]} {"pathway":"GO_REGULATION_OF_MRNA_BINDING","pval":0.90623,"padj":0.98417,"ES":0.37833,"NES":0.48031,"nMoreExtreme":51152,"size":10,"leadingEdge":["EIF3D","FMR1","EIF3E","HNRNPL","EIF4G1","CDK9","EIF4A3","CARM1"]} {"pathway":"GO_PROTEIN_RETENTION_IN_ER_LUMEN","pval":0.84329,"padj":0.97458,"ES":0.36672,"NES":0.4797,"nMoreExtreme":45837,"size":7,"leadingEdge":["KDELR3","KDELR1","ANKRD13C","OS9","KDELR2","RER1"]} {"pathway":"GO_AUDITORY_RECEPTOR_CELL_FATE_COMMITMENT","pval":0.84737,"padj":0.97561,"ES":0.33676,"NES":0.47956,"nMoreExtreme":44101,"size":4,"leadingEdge":["HES1","NOTCH1","RBPJ","JAG2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MICROTUBULE_DEPOLYMERIZATION","pval":0.99298,"padj":1,"ES":0.35815,"NES":0.47949,"nMoreExtreme":62132,"size":22,"leadingEdge":["NAV3","CLASP1","CAMSAP3","HDAC6","MID1","STMN2","APC2","ARHGEF2","CAMSAP2","TTBK2","FGF13","CAMSAP1","APC","CKAP2","KATNB1","TAOK1","CLASP2","MID1IP1","HDGFL3","BMERB1"]} {"pathway":"GO_MITOCHONDRIAL_TRNA_PROCESSING","pval":0.90628,"padj":0.98417,"ES":0.37722,"NES":0.47889,"nMoreExtreme":51155,"size":10,"leadingEdge":["ELAC2","TRIT1","HSD17B10","TRNT1","CDK5RAP1","TRMT5","MTO1","TRMT61B","TRMT10C","PUS1"]} {"pathway":"GO_BERGMANN_GLIAL_CELL_DIFFERENTIATION","pval":0.84421,"padj":0.97458,"ES":0.36553,"NES":0.47814,"nMoreExtreme":45887,"size":7,"leadingEdge":["VIM","ABL1","MAPK1","MAPK3","GFAP","MAP2K1","PTPN11"]} {"pathway":"GO_GERM_CELL_PROLIFERATION","pval":0.84867,"padj":0.97605,"ES":0.33575,"NES":0.47812,"nMoreExtreme":44169,"size":4,"leadingEdge":["PRDX4","EIF2S2","HPGDS","CIB1"]} {"pathway":"GO_TRNA_THREONYLCARBAMOYLADENOSINE_METABOLIC_PROCESS","pval":0.93854,"padj":0.98783,"ES":0.37726,"NES":0.47774,"nMoreExtreme":54137,"size":12,"leadingEdge":["TRIT1","HSD17B10","OSGEP","CDK5RAP1","TRMT5","OSGEPL1","MTO1","TPRKB","TRMT61B","TP53RK","TRMT10C","PUS1"]} {"pathway":"GO_RRNA_TRANSPORT","pval":0.82638,"padj":0.97439,"ES":0.35713,"NES":0.47755,"nMoreExtreme":44351,"size":6,"leadingEdge":["MRPL18","TST","PNPT1","TSC1","RPSA","NPM1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_HEAT_STRESS","pval":0.84942,"padj":0.9763,"ES":0.33524,"NES":0.4774,"nMoreExtreme":44208,"size":4,"leadingEdge":["HSF2","HSF4","HSFX1","HSF1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CILIUM_ASSEMBLY","pval":0.92359,"padj":0.987,"ES":0.37665,"NES":0.47696,"nMoreExtreme":52736,"size":11,"leadingEdge":["MAP4","DNM2","CCP110","TBC1D30","MAK","ODF2L","TCHP","EVI5L","TBC1D7"]} {"pathway":"GO_AUTOPHAGY_INVOLVED_IN_SYMBIOTIC_INTERACTION","pval":0.85017,"padj":0.97645,"ES":0.33479,"NES":0.47676,"nMoreExtreme":44247,"size":4,"leadingEdge":["ATG5","ULK2"]} {"pathway":"GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_CHROMATIN","pval":0.82778,"padj":0.97439,"ES":0.34633,"NES":0.4764,"nMoreExtreme":43800,"size":5,"leadingEdge":["PIH1D1","LRWD1","NIPBL","SGF29","RUVBL2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_FIBROBLAST_MIGRATION","pval":0.8663,"padj":0.97662,"ES":0.36831,"NES":0.47539,"nMoreExtreme":47733,"size":8,"leadingEdge":["HYAL2","ARHGAP4","HAS1","ITGB1BP1","FGF2","BRAF","CYGB"]} {"pathway":"GO_ACTIN_CORTICAL_PATCH_LOCALIZATION","pval":0.84535,"padj":0.97458,"ES":0.36339,"NES":0.47534,"nMoreExtreme":45949,"size":7,"leadingEdge":["WAS","WASL","WIPF1","WIPF3","BIN3","WIPF2","TIGD5"]} {"pathway":"GO_CARDIAC_MUSCLE_MYOBLAST_PROLIFERATION","pval":0.85275,"padj":0.97645,"ES":0.33314,"NES":0.4744,"nMoreExtreme":44381,"size":4,"leadingEdge":["ATF2","MEIS2","GATA6"]} {"pathway":"GO_ENDONUCLEOLYTIC_CLEAVAGE_IN_ITS1_TO_SEPARATE_SSU_RRNA_FROM_5_8S_RRNA_AND_LSU_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA_","pval":0.86674,"padj":0.97662,"ES":0.36701,"NES":0.4737,"nMoreExtreme":47757,"size":8,"leadingEdge":["NOP14","RCL1","UTP20","KRI1","ABT1","RPSA","RPS21","RRS1"]} {"pathway":"GO_RRNA_PSEUDOURIDINE_SYNTHESIS","pval":0.82979,"padj":0.97439,"ES":0.35337,"NES":0.47252,"nMoreExtreme":44534,"size":6,"leadingEdge":["GAR1","DKC1","NAF1","NHP2","RPUSD2","NOP10"]} {"pathway":"GO_NEURAL_PLATE_MORPHOGENESIS","pval":0.83137,"padj":0.97439,"ES":0.34346,"NES":0.47246,"nMoreExtreme":43990,"size":5,"leadingEdge":["DVL2","DVL1","EPB41L5","VANGL2","NOG"]} {"pathway":"GO_AXIAL_MESODERM_DEVELOPMENT","pval":0.83137,"padj":0.97439,"ES":0.34346,"NES":0.47246,"nMoreExtreme":43990,"size":5,"leadingEdge":["EPB41L5","EPHA2","POGLUT1","RPL38","NOG"]} {"pathway":"GO_CHORIO_ALLANTOIC_FUSION","pval":0.85505,"padj":0.97645,"ES":0.3317,"NES":0.47236,"nMoreExtreme":44501,"size":4,"leadingEdge":["DNAJB6","LEF1","CCN1","ZFP36L1"]} {"pathway":"GO_REPLICATIVE_CELL_AGING","pval":0.83214,"padj":0.97439,"ES":0.34296,"NES":0.47177,"nMoreExtreme":44031,"size":5,"leadingEdge":["ERCC1","NEK4","ROMO1","WRN","CHEK2"]} {"pathway":"GO_VESICLE_FUSION_WITH_GOLGI_APPARATUS","pval":0.86726,"padj":0.97662,"ES":0.3655,"NES":0.47176,"nMoreExtreme":47786,"size":8,"leadingEdge":["VTI1B","BET1","GOSR2","VAMP7","USO1","VTI1A","STX5"]} {"pathway":"GO_HYPEROSMOTIC_SALINITY_RESPONSE","pval":0.83214,"padj":0.97439,"ES":0.34294,"NES":0.47174,"nMoreExtreme":44031,"size":5,"leadingEdge":["XRCC5","AKR1B1","TRPV4"]} {"pathway":"GO_HEPARAN_SULFATE_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS_POLYSACCHARIDE_CHAIN_BIOSYNTHETIC_PROCESS","pval":0.83037,"padj":0.97439,"ES":0.35247,"NES":0.47132,"nMoreExtreme":44565,"size":6,"leadingEdge":["NDST1","CSGALNACT1","EXT2","HS2ST1","NDST2","EXT1"]} {"pathway":"GO_COPII_COATED_VESICLE_CARGO_LOADING","pval":0.96001,"padj":0.9934,"ES":0.37029,"NES":0.47124,"nMoreExtreme":56506,"size":14,"leadingEdge":["SEC31B","SAR1A","SEC23A","SEC23B","SEC24A","TBC1D20","RAB1A","SEC31A","SEC24B","SEC24D","MIA3","SEC13"]} {"pathway":"GO_MRNA_MODIFICATION","pval":0.98693,"padj":0.99994,"ES":0.35863,"NES":0.47027,"nMoreExtreme":60614,"size":19,"leadingEdge":["TRMT6","PUS7","PCIF1","CBLL1","PUS3","ZC3H13","METTL16","DKC1","CMTR1","METTL14","WTAP","VIRMA","METTL3","TRUB1","TRMT61A","TRMT61B","TRMT10C","PUS1","CMTR2"]} {"pathway":"GO_CYTOPLASM_ORGANIZATION","pval":0.86768,"padj":0.97662,"ES":0.36425,"NES":0.47015,"nMoreExtreme":47809,"size":8,"leadingEdge":["RRN3","ZMIZ1","TFCP2L1","SOS1","ETV6","KIF5B","FOSL1","PLD6"]} {"pathway":"GO_GRANZYME_MEDIATED_APOPTOTIC_SIGNALING_PATHWAY","pval":0.85828,"padj":0.97645,"ES":0.32991,"NES":0.4698,"nMoreExtreme":44669,"size":4,"leadingEdge":["SRGN","UBE4B","BNIP3","LAMP1"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_JUXTAPARANODE_REGION_OF_AXON","pval":0.83407,"padj":0.97443,"ES":0.34127,"NES":0.46945,"nMoreExtreme":44133,"size":5,"leadingEdge":["EPB41L3","CNTNAP1","NFASC","CNTNAP2","CNTN2"]} {"pathway":"GO_PROTEIN_LIPOYLATION","pval":0.83197,"padj":0.97439,"ES":0.35056,"NES":0.46876,"nMoreExtreme":44651,"size":6,"leadingEdge":["NDUFAB1","LIAS","GCSH","LIPT1","LIPT2","GLRX5"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_FATTY_ACID_BETA_OXIDATION","pval":0.85982,"padj":0.97645,"ES":0.32892,"NES":0.4684,"nMoreExtreme":44749,"size":4,"leadingEdge":["ACACB","ETFBKMT","AKT1"]} {"pathway":"GO_MRNA_CLEAVAGE_INVOLVED_IN_MRNA_PROCESSING","pval":0.93908,"padj":0.98783,"ES":0.36951,"NES":0.46791,"nMoreExtreme":54168,"size":12,"leadingEdge":["CPSF1","CSTF2","CPSF6","NCBP2","NCBP1","FIP1L1","TUT1","CPSF7","CPSF4","NUDT21","CSTF2T","ERN1"]} {"pathway":"GO_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORT","pval":0.84811,"padj":0.97587,"ES":0.35755,"NES":0.4677,"nMoreExtreme":46099,"size":7,"leadingEdge":["SLC25A17","SLC25A36","SLC35B3","SLC35B2","SLC25A32","SLC25A33","SLC25A42"]} {"pathway":"GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME","pval":0.99469,"padj":1,"ES":0.34668,"NES":0.46718,"nMoreExtreme":62583,"size":23,"leadingEdge":["ACD","PIH1D1","CCT4","TCP1","POT1","DKC1","CCT7","NABP2","BRCA2","WRAP53","CCT6A","TERF1","ATM","CCT5","CCT8","LRWD1","CCT3","NIPBL","SPIDR","CCT2","ATR","SGF29","RUVBL2"]} {"pathway":"GO_REGULATION_OF_INTRACELLULAR_LIPID_TRANSPORT","pval":0.83298,"padj":0.97443,"ES":0.34933,"NES":0.46711,"nMoreExtreme":44705,"size":6,"leadingEdge":["ABCA2","SCP2","NUS1","LDLRAP1","ARV1","ANXA2"]} {"pathway":"GO_SNRNA_PROCESSING","pval":0.99691,"padj":1,"ES":0.34167,"NES":0.46626,"nMoreExtreme":63506,"size":25,"leadingEdge":["EXOSC7","EXOSC5","INTS6","USB1","INTS9","INTS10","EXOSC3","INTS2","EXOSC8","EXOSC9","INTS11","EXOSC2","TOE1","INTS14","INTS12","INTS7","INTS3","TUT1","INTS4","INTS1","INTS8","INTS6L"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELLULAR_AMINE_METABOLIC_PROCESS","pval":0.83507,"padj":0.97443,"ES":0.34719,"NES":0.46426,"nMoreExtreme":44817,"size":6,"leadingEdge":["PEBP1","COMT","PAOX","HPRT1","GPR37","ABAT"]} {"pathway":"GO_CARDIAC_MUSCLE_CELL_FATE_COMMITMENT","pval":0.83957,"padj":0.97458,"ES":0.33655,"NES":0.46296,"nMoreExtreme":44424,"size":5,"leadingEdge":["DKK1","ACVR1","TBX3","RBPJ","WT1"]} {"pathway":"GO_CELL_ADHESION_INVOLVED_IN_HEART_MORPHOGENESIS","pval":0.84059,"padj":0.97458,"ES":0.3356,"NES":0.46164,"nMoreExtreme":44478,"size":5,"leadingEdge":["TGFB2","ACVR1","GATA5","TGFBR2","FLRT2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_DNA_CATABOLIC_PROCESS","pval":0.84108,"padj":0.97458,"ES":0.33526,"NES":0.46118,"nMoreExtreme":44504,"size":5,"leadingEdge":["BAX","ATM","ENDOG","ST20","HSF1"]} {"pathway":"GO_C_TERMINAL_PROTEIN_LIPIDATION","pval":0.83913,"padj":0.97458,"ES":0.34283,"NES":0.45842,"nMoreExtreme":45035,"size":6,"leadingEdge":["ATG5","ATG16L1","GPLD1","ATG12","WIPI2"]} {"pathway":"GO_PROTEIN_NEDDYLATION","pval":0.96033,"padj":0.9934,"ES":0.36007,"NES":0.45822,"nMoreExtreme":56525,"size":14,"leadingEdge":["DCUN1D1","RBX1","DCUN1D4","RNF7","RPL5","NEDD8","UBE2M","DCUN1D5","RPL11","UBA3","DCUN1D2","NAE1"]} {"pathway":"GO_PRIMARY_AMINO_COMPOUND_METABOLIC_PROCESS","pval":0.83943,"padj":0.97458,"ES":0.34253,"NES":0.45802,"nMoreExtreme":45051,"size":6,"leadingEdge":["CHKA","PDE1B","SRD5A1","RNF180","ATP7A","BTBD9"]} {"pathway":"GO_MICROTUBULE_NUCLEATION_BY_MICROTUBULE_ORGANIZING_CENTER","pval":0.87129,"padj":0.97717,"ES":0.35434,"NES":0.45735,"nMoreExtreme":48008,"size":8,"leadingEdge":["NIN","CEP192","TUBGCP3","TUBGCP6","TUBGCP2","TUBGCP4"]} {"pathway":"GO_PSEUDOURIDINE_SYNTHESIS","pval":0.97986,"padj":0.99901,"ES":0.35359,"NES":0.45727,"nMoreExtreme":59212,"size":17,"leadingEdge":["RPUSD1","PUS7","GAR1","PUS3","PUS7L","DKC1","NAF1","NHP2","RPUSD3","PUS10","RPUSD4","TRUB1","RPUSD2","TRUB2","PUSL1","PUS1","NOP10"]} {"pathway":"GO_ANTIBIOTIC_TRANSPORT","pval":0.84071,"padj":0.97458,"ES":0.34131,"NES":0.45639,"nMoreExtreme":45120,"size":6,"leadingEdge":["RALBP1","SLC25A1","MFSD10","SFXN5","SLC13A3"]} {"pathway":"GO_MRNA_METHYLATION","pval":0.96043,"padj":0.9934,"ES":0.35853,"NES":0.45627,"nMoreExtreme":56531,"size":14,"leadingEdge":["TRMT6","PCIF1","CBLL1","ZC3H13","METTL16","CMTR1","METTL14","WTAP","VIRMA","METTL3","TRMT61A","TRMT61B","TRMT10C","CMTR2"]} {"pathway":"GO_SYNAPTIC_TRANSMISSION_GLYCINERGIC","pval":0.97489,"padj":0.99814,"ES":0.30583,"NES":0.45616,"nMoreExtreme":48990,"size":2,"leadingEdge":["GLRB","SLC6A9"]} {"pathway":"GO_VIRAL_TRANSLATION","pval":0.96045,"padj":0.9934,"ES":0.35794,"NES":0.45551,"nMoreExtreme":56532,"size":14,"leadingEdge":["PTBP1","EIF3L","EIF3D","EIF3B","EIF3A","EIF2AK4","EIF3G","DHX9","SSB","DENR","EIF2D"]} {"pathway":"GO_RESPONSE_TO_COBALT_ION","pval":0.90892,"padj":0.98471,"ES":0.35856,"NES":0.45521,"nMoreExtreme":51304,"size":10,"leadingEdge":["CASP8","TIGAR","ATF1","SERPINF1","CASP9","ALAD","CASP3","ATP7A","BNIP3","D2HGDH"]} {"pathway":"GO_REGULATION_OF_AEROBIC_RESPIRATION","pval":0.872,"padj":0.9773,"ES":0.35246,"NES":0.45492,"nMoreExtreme":48047,"size":8,"leadingEdge":["HIF1A","NOP53","TRPV4","IDE","CBFA2T3","VCP","BNIP3","SHMT2"]} {"pathway":"GO_SIGNAL_PEPTIDE_PROCESSING","pval":0.92536,"padj":0.987,"ES":0.3591,"NES":0.45474,"nMoreExtreme":52837,"size":11,"leadingEdge":["PCSK5","HM13","CLN5","SPCS1","SPCS2","SPCS3","FURIN","SEC11A","SPPL3","SEC11C"]} {"pathway":"GO_TELOMERASE_RNA_LOCALIZATION","pval":0.98697,"padj":0.99994,"ES":0.3466,"NES":0.45449,"nMoreExtreme":60617,"size":19,"leadingEdge":["CCT4","TCP1","DKC1","CCT7","PARN","WRAP53","SHQ1","NAF1","NHP2","CCT6A","CCT5","CCT8","CCT3","CCT2","EXOSC10","DCP2","RUVBL1","NOP10","RUVBL2"]} {"pathway":"GO_LIPID_GLYCOSYLATION","pval":0.8916,"padj":0.98217,"ES":0.35472,"NES":0.45309,"nMoreExtreme":49825,"size":9,"leadingEdge":["GBA2","ST3GAL4","B4GALNT1","GBGT1","ST3GAL2","B4GALNT2","ABO","GBA","SLC35C1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MYOBLAST_PROLIFERATION","pval":0.84347,"padj":0.97458,"ES":0.3385,"NES":0.45264,"nMoreExtreme":45268,"size":6,"leadingEdge":["PPARD","ATF2","MEIS2","GATA6","PAXBP1"]} {"pathway":"GO_PYRIMIDINE_NUCLEOBASE_BIOSYNTHETIC_PROCESS","pval":0.87276,"padj":0.97746,"ES":0.35059,"NES":0.45251,"nMoreExtreme":48089,"size":8,"leadingEdge":["CPS1","CTPS2","CAD","DHODH","UMPS"]} {"pathway":"GO_2_OXOGLUTARATE_METABOLIC_PROCESS","pval":0.9684,"padj":0.99598,"ES":0.35383,"NES":0.45207,"nMoreExtreme":57544,"size":15,"leadingEdge":["L2HGDH","DLD","OGDH","PHYH","AADAT","DLST","GOT1","GOT2","MRPS36","KYAT3","IDH1","ADHFE1","GPT2","D2HGDH","IDH2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ARP2_3_COMPLEX_MEDIATED_ACTIN_NUCLEATION","pval":0.87305,"padj":0.97759,"ES":0.35007,"NES":0.45184,"nMoreExtreme":48105,"size":8,"leadingEdge":["WAS","NCKAP1","WASL","WASF1","FCHSD2","ABI2"]} {"pathway":"GO_NADP_METABOLIC_PROCESS","pval":0.89192,"padj":0.98238,"ES":0.35371,"NES":0.4518,"nMoreExtreme":49843,"size":9,"leadingEdge":["ME1","KCNAB2","ME2","NNT","TP53I3","IDH1","G6PD","DCXR","IDH2"]} {"pathway":"GO_DOPAMINE_CATABOLIC_PROCESS","pval":0.87809,"padj":0.97973,"ES":0.31721,"NES":0.45172,"nMoreExtreme":45700,"size":4,"leadingEdge":["MOXD1","COMT"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_I","pval":0.97785,"padj":0.99901,"ES":0.30207,"NES":0.45055,"nMoreExtreme":49139,"size":2,"leadingEdge":["NOP53","FLNA"]} {"pathway":"GO_REGULATION_OF_MALE_GONAD_DEVELOPMENT","pval":0.84528,"padj":0.97458,"ES":0.33657,"NES":0.45006,"nMoreExtreme":45365,"size":6,"leadingEdge":["SEMA3A","SOX9","WNT4","CITED2","ZFPM2","WT1"]} {"pathway":"GO_PRIMITIVE_STREAK_FORMATION","pval":0.85272,"padj":0.97645,"ES":0.32681,"NES":0.44956,"nMoreExtreme":45120,"size":5,"leadingEdge":["LRP6","SRF","WNT5A"]} {"pathway":"GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_DAMAGE_RECOGNITION","pval":0.99469,"padj":1,"ES":0.33339,"NES":0.44927,"nMoreExtreme":62583,"size":23,"leadingEdge":["RBX1","COPS7A","RAD23B","COPS5","DDB2","XPA","COPS4","CUL4A","COPS3","PARP1","RPS27A","COPS7B","CETN2","UBC","XPC","CUL4B","COPS2","DDB1","COPS6","GPS1","UBB"]} {"pathway":"GO_NEURAL_CREST_FORMATION","pval":0.90984,"padj":0.98498,"ES":0.35375,"NES":0.4491,"nMoreExtreme":51356,"size":10,"leadingEdge":["FUZ","LRP6","TCOF1","SFRP1","KLHL12","SOX9","PEF1","KBTBD8","NOLC1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_RNA_SPLICING","pval":0.99911,"padj":1,"ES":0.31955,"NES":0.44881,"nMoreExtreme":65131,"size":30,"leadingEdge":["THRAP3","U2AF2","DAZAP1","RBM22","CIRBP","SNW1","SRSF5","CELF4","RBM3","SNRNP70","SETX","ZPR1","PRPF19","NUP98","PRDX6","HABP4","SRSF1","TRA2B","NCBP1","SF3B4","HNRNPLL","PIK3R1","RBMX"]} {"pathway":"GO_REGULATION_OF_GOLGI_TO_PLASMA_MEMBRANE_PROTEIN_TRANSPORT","pval":0.85751,"padj":0.97645,"ES":0.34284,"NES":0.44847,"nMoreExtreme":46610,"size":7,"leadingEdge":["GOPC","CSK","LYPLA1","ACSL3","CNST","PKDCC"]} {"pathway":"GO_BEHAVIORAL_RESPONSE_TO_COCAINE","pval":0.87459,"padj":0.97837,"ES":0.34723,"NES":0.44817,"nMoreExtreme":48190,"size":8,"leadingEdge":["DRD4","HOMER2","SNCA","SDK1","HOMER1","CDK5","FADD","ABAT"]} {"pathway":"GO_PROTEIN_MATURATION_BY_PROTEIN_FOLDING","pval":0.89274,"padj":0.98267,"ES":0.35077,"NES":0.44804,"nMoreExtreme":49889,"size":9,"leadingEdge":["ERO1B","FKBP1A","WFS1","AIP","FKBP1B","PRDX4"]} {"pathway":"GO_REGULATION_OF_NEUROTRANSMITTER_RECEPTOR_LOCALIZATION_TO_POSTSYNAPTIC_SPECIALIZATION_MEMBRANE","pval":0.8747,"padj":0.97837,"ES":0.34689,"NES":0.44774,"nMoreExtreme":48196,"size":8,"leadingEdge":["PRKCZ","GPC4","RAP1A","IQSEC2","ADAM10","DAG1","HRAS","GPC6"]} {"pathway":"GO_RIBONUCLEOPROTEIN_COMPLEX_DISASSEMBLY","pval":0.96846,"padj":0.99598,"ES":0.3504,"NES":0.44768,"nMoreExtreme":57548,"size":15,"leadingEdge":["DHX8","MTIF2","TFIP11","ZFAND1","MTIF3","KLC1","DENR","DYRK3","EIF2D","MRRF","PELO","GFM2","VCP","KIF5B"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_NEUTROPHIL_ACTIVATION","pval":0.85527,"padj":0.97645,"ES":0.32487,"NES":0.44688,"nMoreExtreme":45255,"size":5,"leadingEdge":["GRN","FCGR2B","ABR","CD300A","BCR"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_GONAD_DEVELOPMENT","pval":0.85541,"padj":0.97645,"ES":0.3247,"NES":0.44665,"nMoreExtreme":45262,"size":5,"leadingEdge":["AMH","WNT4","ZFPM2","WT1","HYAL3"]} {"pathway":"GO_ESCRT_COMPLEX_DISASSEMBLY","pval":0.91016,"padj":0.98504,"ES":0.35164,"NES":0.44642,"nMoreExtreme":51374,"size":10,"leadingEdge":["VTA1","CHMP2B","CHMP5","VPS4B","CHMP2A","CHMP1A","VPS4A","CHMP7"]} {"pathway":"GO_REGULATION_OF_ACTIVATION_INDUCED_CELL_DEATH_OF_T_CELLS","pval":0.85571,"padj":0.97645,"ES":0.32448,"NES":0.44634,"nMoreExtreme":45278,"size":5,"leadingEdge":["GPAM","RIPK3","TSC22D3","FADD","TNFRSF4"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TUBULIN_DEACETYLATION","pval":0.85582,"padj":0.97645,"ES":0.32431,"NES":0.44611,"nMoreExtreme":45284,"size":5,"leadingEdge":["FRY","BEX4","PRKAA1","PRKAA2","MAPT"]} {"pathway":"GO_MITOCHONDRIAL_RNA_METABOLIC_PROCESS","pval":0.99148,"padj":1,"ES":0.33548,"NES":0.44598,"nMoreExtreme":61706,"size":21,"leadingEdge":["ELAC2","TRIT1","HSD17B10","TRNT1","CDK5RAP1","EARS2","WARS2","DARS2","AARS2","TRMT5","MTO1","TBRG4","PNPT1","FASTKD1","YARS2","TARS2"]} {"pathway":"GO_REGULATION_OF_RECEPTOR_LOCALIZATION_TO_SYNAPSE","pval":0.97501,"padj":0.99814,"ES":0.34705,"NES":0.44584,"nMoreExtreme":58405,"size":16,"leadingEdge":["ARHGAP44","TYROBP","PRKCZ","GRIPAP1","GPC4","STX7","DBN1","RAP1A","IQSEC2","ADAM10","NPTN","GRASP","DAG1","HRAS","CNIH2","GPC6"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SEQUESTERING_OF_TRIGLYCERIDE","pval":0.85613,"padj":0.97645,"ES":0.32403,"NES":0.44572,"nMoreExtreme":45300,"size":5,"leadingEdge":["ABHD5","OSBPL8","PPARG","PNPLA2","PPARA"]} {"pathway":"GO_RIBOSOME_DISASSEMBLY","pval":0.87579,"padj":0.979,"ES":0.34455,"NES":0.44471,"nMoreExtreme":48256,"size":8,"leadingEdge":["MTIF2","MTIF3","DENR","EIF2D","MRRF","PELO","GFM2"]} {"pathway":"GO_SNRNA_3_END_PROCESSING","pval":0.97996,"padj":0.99901,"ES":0.34387,"NES":0.44471,"nMoreExtreme":59218,"size":17,"leadingEdge":["EXOSC7","EXOSC5","INTS6","USB1","EXOSC3","INTS2","EXOSC8","EXOSC9","EXOSC2","TOE1","INTS14","INTS7","INTS1","INTS8","INTS6L"]} {"pathway":"GO_PLANAR_CELL_POLARITY_PATHWAY_INVOLVED_IN_AXIS_ELONGATION","pval":0.85784,"padj":0.97645,"ES":0.32251,"NES":0.44364,"nMoreExtreme":45391,"size":5,"leadingEdge":["SFRP1","WNT5A","SFRP2","VANGL2","MAGI2"]} {"pathway":"GO_NOTOCHORD_MORPHOGENESIS","pval":0.87625,"padj":0.97907,"ES":0.34352,"NES":0.44339,"nMoreExtreme":48281,"size":8,"leadingEdge":["GLI2","GLI1","WNT5A","EPHA2","KDM6A","CRB2","EFNA1","NOG"]} {"pathway":"GO_NUCLEOTIDE_EXCISION_REPAIR_PREINCISION_COMPLEX_ASSEMBLY","pval":0.99892,"padj":1,"ES":0.31698,"NES":0.44286,"nMoreExtreme":64823,"size":29,"leadingEdge":["MNAT1","RBX1","ERCC2","RPA3","GTF2H1","GTF2H3","RPA2","RAD23B","CHD1L","RPA1","CDK7","CCNH","DDB2","ERCC5","XPA","CUL4A","PARP1","RPS27A","GTF2H2","CETN2","UBC","XPC","CUL4B","ERCC3","DDB1","UBB"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TELOMERASE_RNA_LOCALIZATION_TO_CAJAL_BODY","pval":0.96851,"padj":0.99598,"ES":0.34652,"NES":0.44273,"nMoreExtreme":57551,"size":15,"leadingEdge":["CCT4","TCP1","DKC1","CCT7","SHQ1","NAF1","NHP2","CCT6A","CCT5","CCT8","CCT3","CCT2","RUVBL1","NOP10","RUVBL2"]} {"pathway":"GO_NEUROTRANSMITTER_RECEPTOR_LOCALIZATION_TO_POSTSYNAPTIC_SPECIALIZATION_MEMBRANE","pval":0.96104,"padj":0.9934,"ES":0.34701,"NES":0.4416,"nMoreExtreme":56567,"size":14,"leadingEdge":["PRKCZ","CACNG4","DLG1","GPC4","RAP1A","IQSEC2","DLG4","ADAM10","CACNG8","DLG2","GPHN","DAG1","HRAS","GPC6"]} {"pathway":"GO_ER_ASSOCIATED_MISFOLDED_PROTEIN_CATABOLIC_PROCESS","pval":0.94045,"padj":0.98812,"ES":0.34706,"NES":0.43948,"nMoreExtreme":54247,"size":12,"leadingEdge":["POMT2","UFD1","UGGT2","SDF2L1","SDF2","UGGT1","TOR1A","DERL1","RNF185"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ACTIVIN_RECEPTOR_SIGNALING_PATHWAY","pval":0.86263,"padj":0.97662,"ES":0.33561,"NES":0.43901,"nMoreExtreme":46888,"size":7,"leadingEdge":["ZC3H3","FGF9","ACVR2B","ACVR2A","ACVR1B"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SMAD_PROTEIN_SIGNAL_TRANSDUCTION","pval":0.93952,"padj":0.98783,"ES":0.29759,"NES":0.43844,"nMoreExtreme":48029,"size":3,"leadingEdge":["PBLD","FAM89B","VEPH1"]} {"pathway":"GO_AMYLOID_BETA_CLEARANCE_BY_TRANSCYTOSIS","pval":0.86333,"padj":0.97662,"ES":0.33468,"NES":0.43779,"nMoreExtreme":46926,"size":7,"leadingEdge":["PICALM","RAB11A","LRP1","CLTC","RAB5A","LRPAP1","RAB11B"]} {"pathway":"GO_POSITIVE_REGULATION_OF_HISTONE_UBIQUITINATION","pval":0.86399,"padj":0.97662,"ES":0.318,"NES":0.43744,"nMoreExtreme":45716,"size":5,"leadingEdge":["KDM1A","RNF40","CDK9","RNF20"]} {"pathway":"GO_REGULATION_OF_HISTONE_H2B_UBIQUITINATION","pval":0.86399,"padj":0.97662,"ES":0.318,"NES":0.43744,"nMoreExtreme":45716,"size":5,"leadingEdge":["WDR70","RNF40","CDK9","RNF20"]} {"pathway":"GO_PROSTATE_GLANDULAR_ACINUS_DEVELOPMENT","pval":0.89543,"padj":0.98309,"ES":0.34239,"NES":0.43734,"nMoreExtreme":50039,"size":9,"leadingEdge":["FGFR2","ESR1","SFRP1","WDR77","FOXA1","NOTCH1","HOXB13","FRS2"]} {"pathway":"GO_HISTONE_H3_K36_METHYLATION","pval":0.94075,"padj":0.98812,"ES":0.34455,"NES":0.43632,"nMoreExtreme":54264,"size":12,"leadingEdge":["NSD2","ASH1L","BRD4","SMYD2","NSD3","PAXIP1","IWS1","NSD1","SETMAR","SETD2","BCOR","SETD3"]} {"pathway":"GO_REGULATION_OF_LIGASE_ACTIVITY","pval":0.87886,"padj":0.97976,"ES":0.33775,"NES":0.43594,"nMoreExtreme":48425,"size":8,"leadingEdge":["GCLM","XRCC1","TFIP11","AIMP2","RIPK3","XRCC4","MID1IP1"]} {"pathway":"GO_ADENYLATE_CYCLASE_INHIBITING_DOPAMINE_RECEPTOR_SIGNALING_PATHWAY","pval":0.89832,"padj":0.98382,"ES":0.30429,"NES":0.43332,"nMoreExtreme":46753,"size":4,"leadingEdge":["DRD4","PRMT5"]} {"pathway":"GO_NUCLEAR_MIGRATION_ALONG_MICROTUBULE","pval":0.86779,"padj":0.97662,"ES":0.31493,"NES":0.43321,"nMoreExtreme":45917,"size":5,"leadingEdge":["SYNE2","SUN2","TRIM58","SUN1","TMEM201"]} {"pathway":"GO_CANNABINOID_SIGNALING_PATHWAY","pval":0.86794,"padj":0.97662,"ES":0.31476,"NES":0.43297,"nMoreExtreme":45925,"size":5,"leadingEdge":["MGLL","DAGLA","ABHD6","DAGLB","CNR2"]} {"pathway":"GO_INTESTINAL_LIPID_ABSORPTION","pval":0.85836,"padj":0.97645,"ES":0.32337,"NES":0.4324,"nMoreExtreme":46067,"size":6,"leadingEdge":["LIMA1","APOA1","LDLR","CD36","CEL","AKR1C1"]} {"pathway":"GO_OXIDATIVE_DNA_DEMETHYLATION","pval":0.86996,"padj":0.97681,"ES":0.31352,"NES":0.43127,"nMoreExtreme":46032,"size":5,"leadingEdge":["ALKBH1","TDG","FTO","ALKBH3","ALKBH2"]} {"pathway":"GO_NADH_DEHYDROGENASE_COMPLEX_ASSEMBLY","pval":1,"padj":1,"ES":0.27828,"NES":0.43126,"nMoreExtreme":72022,"size":58,"leadingEdge":["NDUFAF7","NDUFAB1","NDUFS1","NDUFB4","BCS1L","TIMM21","NDUFB2","NDUFB7","NDUFAF5","TAZ","DMAC2","COA1","NDUFC1","FOXRED1","NDUFS8","TIMMDC1","NDUFS7","NDUFB3","NDUFA8","NDUFAF4","NDUFA1","NDUFA5","ECSIT","NDUFA10","NDUFA2","NDUFB5","DMAC1","NDUFAF1","NDUFA9","NDUFB10","NDUFS6","NDUFB11","NDUFB9","NDUFC2","NUBPL","OXA1L","NDUFAF6","NDUFS2","NDUFV3","NDUFAF2","NDUFS4","NDUFB6","NDUFB8","NDUFV1","NDUFS5","NDUFA3","TMEM126B","NDUFA11","ACAD9","NDUFAF3","NDUFV2","NDUFB1","NDUFA12","NDUFA6","NDUFA13"]} {"pathway":"GO_REACTIVE_NITROGEN_SPECIES_METABOLIC_PROCESS","pval":0.86811,"padj":0.97662,"ES":0.32811,"NES":0.42919,"nMoreExtreme":47186,"size":7,"leadingEdge":["CPS1","MARC2","SELENOS","TLR2","SUOX","TLR6","MARC1"]} {"pathway":"GO_NADH_METABOLIC_PROCESS","pval":0.8689,"padj":0.97662,"ES":0.32715,"NES":0.42794,"nMoreExtreme":47229,"size":7,"leadingEdge":["MDH1","OGDH","NUDT12","MDH2","GPD1L","VCP","NUDT17"]} {"pathway":"GO_RIBOSOMAL_SMALL_SUBUNIT_BIOGENESIS","pval":1,"padj":1,"ES":0.27287,"NES":0.42709,"nMoreExtreme":73038,"size":63,"leadingEdge":["TSR3","RIOK2","RPS5","NOP14","RIOK3","RPS16","RPS19","UTP6","BYSL","RPS15","NOL10","UTP25","HEATR1","RCL1","UTP20","RRP36","RPS10","RIOK1","MRPS7","EMG1","KRI1","NGDN","NOL11","UTP3","ERAL1","NAT10","LTV1","MRPS9","RPS6","RPS24","UTP4","NOB1","RPS8","ABT1","NOM1","UTP23","SURF6","DHX37","SRFBP1","TSR2","FAM207A","LSM6","RPS14","DCAF13","BMS1","BTRC","TSR1","RPSA","RPS21","RPS7","RPL38","RPS27","RRS1","NPM1","MRPS11","RPS17","RRP7BP","TBL3","RPS27L"]} {"pathway":"GO_BRANCHED_CHAIN_AMINO_ACID_CATABOLIC_PROCESS","pval":0.98707,"padj":0.99994,"ES":0.32492,"NES":0.42606,"nMoreExtreme":60623,"size":19,"leadingEdge":["BCAT1","HSD17B10","ACAT1","MCCC1","BCKDHB","DLD","BCKDK","BCAT2","HIBADH","ALDH6A1","IVD","MCCC2","DBT","AUH","ACAD8"]} {"pathway":"GO_NEURONAL_SIGNAL_TRANSDUCTION","pval":0.86415,"padj":0.97662,"ES":0.31835,"NES":0.42569,"nMoreExtreme":46378,"size":6,"leadingEdge":["RTN4R","KCNA1","CLU","OLFM1"]} {"pathway":"GO_NEURAL_PLATE_DEVELOPMENT","pval":0.88311,"padj":0.98086,"ES":0.3297,"NES":0.42555,"nMoreExtreme":48659,"size":8,"leadingEdge":["DVL2","DVL1","EPB41L5","VANGL2","C2CD3","CTNNB1","NOG","PTCH1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_RNA_SPLICING","pval":0.99694,"padj":1,"ES":0.31139,"NES":0.42493,"nMoreExtreme":63508,"size":25,"leadingEdge":["PTBP1","SFSWAP","U2AF2","CELF4","HNRNPL","C1QBP","RPS13","SRSF9","SRSF7","SRSF4","PTBP2","PTBP3","HNRNPA2B1","SRSF6","RBM42","TMBIM6","RBMX","SAP18","SRSF12","DYRK1A"]} {"pathway":"GO_PLUS_END_DIRECTED_ORGANELLE_TRANSPORT_ALONG_MICROTUBULE","pval":0.87137,"padj":0.97717,"ES":0.32434,"NES":0.42427,"nMoreExtreme":47363,"size":7,"leadingEdge":["KIFAP3","KIF3B","KIF3A","KIF13A","FYCO1","KIF5B","MAPT"]} {"pathway":"GO_AMINO_ACID_BETAINE_TRANSPORT","pval":0.90779,"padj":0.98435,"ES":0.29778,"NES":0.42404,"nMoreExtreme":47246,"size":4,"leadingEdge":["SLC22A16","SLC38A2","SLC22A4","SLC22A5"]} {"pathway":"GO_N_TERMINAL_PROTEIN_AMINO_ACID_ACETYLATION","pval":0.96888,"padj":0.99598,"ES":0.33179,"NES":0.42391,"nMoreExtreme":57573,"size":15,"leadingEdge":["CREBBP","EP300","NAA10","NAA40","NAA25","KAT2B","NAA50","NAA60","SOX4","NAA35","NAA30","NAA15","NAA16","NAA20"]} {"pathway":"GO_GONADOTROPIN_SECRETION","pval":0.86588,"padj":0.97662,"ES":0.31687,"NES":0.42371,"nMoreExtreme":46471,"size":6,"leadingEdge":["INHBA","TBX3","SMAD4","TMF1","INHBB"]} {"pathway":"GO_PROTEIN_QUALITY_CONTROL_FOR_MISFOLDED_OR_INCOMPLETELY_SYNTHESIZED_PROTEINS","pval":0.99755,"padj":1,"ES":0.30836,"NES":0.42336,"nMoreExtreme":63825,"size":26,"leadingEdge":["POMT2","CUL3","ATXN3","UFD1","HDAC6","UGGT2","LONP2","STUB1","UBE2W","CLPP","SDF2L1","SDF2","UGGT1","YME1L1","TOR1A","DERL1","RNF185","FBXL17","NGLY1","OMA1","ANKZF1","VCP"]} {"pathway":"GO_LIPOPHAGY","pval":0.86655,"padj":0.97662,"ES":0.31622,"NES":0.42284,"nMoreExtreme":46507,"size":6,"leadingEdge":["RAB7A","SPTLC1","SPTLC2","SESN2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER","pval":0.98011,"padj":0.99901,"ES":0.3265,"NES":0.42224,"nMoreExtreme":59227,"size":17,"leadingEdge":["PAF1","CDK13","SUPT16H","ELL","SUPT6H","GTF2F1","EAPP","CDC73","CDK9","RTF1","WDR61","BRD4","ELOC","LEO1","CDK12"]} {"pathway":"GO_BARBED_END_ACTIN_FILAMENT_CAPPING","pval":0.98011,"padj":0.99901,"ES":0.32592,"NES":0.42149,"nMoreExtreme":59227,"size":17,"leadingEdge":["CAPG","ADD2","CAPZB","CARMIL1","ADD1","TRIOBP","MTPN","CAPZA1","RDX","GSN","ADD3","TWF1","EPS8","CARMIL2"]} {"pathway":"GO_COP9_SIGNALOSOME_ASSEMBLY","pval":0.9518,"padj":0.99278,"ES":0.28585,"NES":0.42114,"nMoreExtreme":48657,"size":3,"leadingEdge":["COPS7A","COPS7B","COPS8"]} {"pathway":"GO_DNA_DOUBLE_STRAND_BREAK_PROCESSING_INVOLVED_IN_REPAIR_VIA_SINGLE_STRAND_ANNEALING","pval":0.86823,"padj":0.97662,"ES":0.31466,"NES":0.42076,"nMoreExtreme":46597,"size":6,"leadingEdge":["RAD52","RBBP8","SLX1A","RNF138","SLX1B","SLX4"]} {"pathway":"GO_PENTOSE_CATABOLIC_PROCESS","pval":0.91142,"padj":0.98539,"ES":0.29525,"NES":0.42044,"nMoreExtreme":47435,"size":4,"leadingEdge":["XYLB","NUDT5","RBKS","RPE"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_BRAIN_DERIVED_NEUROTROPHIC_FACTOR_STIMULUS","pval":0.90026,"padj":0.98417,"ES":0.32908,"NES":0.42033,"nMoreExtreme":50309,"size":9,"leadingEdge":["EEF2K","SH3GL2","WASF1","PDPK1","EIF4A3","TMEM108","NTRK2","EEF2"]} {"pathway":"GO_RESPONSE_TO_UV_A","pval":0.8799,"padj":0.98032,"ES":0.30554,"NES":0.4203,"nMoreExtreme":46558,"size":5,"leadingEdge":["CCND1","AKT1","EGFR","PPID","MME"]} {"pathway":"GO_POSITIVE_REGULATION_OF_LIGASE_ACTIVITY","pval":0.87403,"padj":0.97824,"ES":0.32086,"NES":0.41971,"nMoreExtreme":47508,"size":7,"leadingEdge":["GCLM","XRCC1","AIMP2","RIPK3","XRCC4","MID1IP1","NHEJ1"]} {"pathway":"GO_HYDROGEN_PEROXIDE_METABOLIC_PROCESS","pval":0.90105,"padj":0.98417,"ES":0.3275,"NES":0.41832,"nMoreExtreme":50353,"size":9,"leadingEdge":["HDAC6","PARK7","RAC2","RAC1","EGFR","MMP3","PINK1","PRDX2"]} {"pathway":"GO_PROTEIN_INSERTION_INTO_MITOCHONDRIAL_INNER_MEMBRANE","pval":0.92933,"padj":0.98762,"ES":0.32931,"NES":0.417,"nMoreExtreme":53064,"size":11,"leadingEdge":["AGK","TIMM13","TIMM9","ROMO1","TIMM10","TIMM29","OXA1L","MAIP1","COX18","TIMM22","NDUFA13"]} {"pathway":"GO_MEMBRANE_REPOLARIZATION_DURING_ATRIAL_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL","pval":0.88381,"padj":0.98086,"ES":0.30212,"NES":0.41559,"nMoreExtreme":46765,"size":5,"leadingEdge":["KCNQ1","KCNN2","KCNJ5","KCNJ3","FLNA"]} {"pathway":"GO_RNA_5_END_PROCESSING","pval":0.98714,"padj":0.99994,"ES":0.31663,"NES":0.41519,"nMoreExtreme":60627,"size":19,"leadingEdge":["HSD17B10","NOP14","USP14","POP1","POP4","THG1L","UTP20","RPP40","PNPT1","SSB","ABT1","RPP30","RPP38","RPP14","POP5","POP7","TRMT10C","RPP25"]} {"pathway":"GO_LYSOSOMAL_LUMEN_ACIDIFICATION","pval":0.88797,"padj":0.98088,"ES":0.32147,"NES":0.41492,"nMoreExtreme":48927,"size":8,"leadingEdge":["GRN","CLN5","CLN6","PPT1","CCDC115","SNAPIN"]} {"pathway":"GO_RESPONSE_TO_MISFOLDED_PROTEIN","pval":0.99472,"padj":1,"ES":0.30763,"NES":0.41456,"nMoreExtreme":62585,"size":23,"leadingEdge":["POMT2","CUL3","ATXN3","UFD1","HDAC6","UGGT2","STUB1","UBE2W","CLU","SDF2L1","SDF2","UGGT1","TOR1A","DERL1","RNF185","DNAJB12","ANKZF1","DNAJB14","VCP","DNAJC18","KLHL15"]} {"pathway":"GO_MATURATION_OF_SSU_RRNA","pval":0.99996,"padj":1,"ES":0.2778,"NES":0.41447,"nMoreExtreme":69184,"size":44,"leadingEdge":["TSR3","RIOK2","NOP14","RIOK3","RPS16","RPS19","UTP6","BYSL","NOL10","UTP25","HEATR1","RCL1","UTP20","RRP36","RIOK1","KRI1","NGDN","NOL11","UTP3","NAT10","MRPS9","UTP4","NOB1","RPS8","ABT1","UTP23","DHX37","SRFBP1","TSR2","FAM207A","LSM6","RPS14","DCAF13","BMS1","BTRC","TSR1","RPSA"]} {"pathway":"GO_REGULATION_OF_TUBULIN_DEACETYLATION","pval":0.90242,"padj":0.98417,"ES":0.32438,"NES":0.41433,"nMoreExtreme":50430,"size":9,"leadingEdge":["FRY","EP300","BEX4","PRKAA1","NEK3","PRKAA2","FNTA","TADA3","MAPT"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME","pval":0.98939,"padj":1,"ES":0.31345,"NES":0.41382,"nMoreExtreme":61158,"size":20,"leadingEdge":["PTBP1","SFSWAP","U2AF2","CELF4","HNRNPL","C1QBP","SRSF9","SRSF7","SRSF4","HNRNPA2B1","SRSF6","RBM42","RBMX","SAP18","SRSF12","DYRK1A","HNRNPK"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ARP2_3_COMPLEX_MEDIATED_ACTIN_NUCLEATION","pval":0.88583,"padj":0.98086,"ES":0.30071,"NES":0.41365,"nMoreExtreme":46872,"size":5,"leadingEdge":["PICK1","GMFG","HIP1R","CORO1B","GMFB"]} {"pathway":"GO_LIPID_DIGESTION","pval":0.87777,"padj":0.97973,"ES":0.31614,"NES":0.41354,"nMoreExtreme":47711,"size":7,"leadingEdge":["LIMA1","APOA1","LDLR","CD36","CEL","AKR1C1","ASAH2"]} {"pathway":"GO_VESICLE_CARGO_LOADING","pval":0.98939,"padj":1,"ES":0.31321,"NES":0.41351,"nMoreExtreme":61158,"size":20,"leadingEdge":["PICALM","SEC31B","SAR1A","TMED2","SEC23A","SEC23B","SEC24A","TBC1D20","KIF13A","RAB1A","SEC31A","SEC24B","MIA2","SEC24D","MIA3","SEC13"]} {"pathway":"GO_REGULATION_OF_PROTEIN_LIPIDATION","pval":0.91928,"padj":0.987,"ES":0.29008,"NES":0.41309,"nMoreExtreme":47844,"size":4,"leadingEdge":["RAB3GAP1","RAB3GAP2","GBA","SVIP"]} {"pathway":"GO_MINUS_END_DIRECTED_ORGANELLE_TRANSPORT_ALONG_MICROTUBULE","pval":0.8865,"padj":0.98086,"ES":0.30021,"NES":0.41296,"nMoreExtreme":46907,"size":5,"leadingEdge":["MREG","BICD1","RAB6A","BICD2","DYNC1H1"]} {"pathway":"GO_BRANCHED_CHAIN_AMINO_ACID_TRANSPORT","pval":0.88657,"padj":0.98086,"ES":0.30015,"NES":0.41288,"nMoreExtreme":46911,"size":5,"leadingEdge":["SLC6A15","SLC38A7","SLC3A2","SLC38A9","SLC6A17"]} {"pathway":"GO_REGULATION_OF_HYDROGEN_PEROXIDE_METABOLIC_PROCESS","pval":0.87836,"padj":0.97973,"ES":0.3153,"NES":0.41243,"nMoreExtreme":47743,"size":7,"leadingEdge":["HDAC6","RAC2","RAC1","MMP3","PINK1","PRDX2","NOXA1"]} {"pathway":"GO_PROTEIN_DENEDDYLATION","pval":0.91681,"padj":0.987,"ES":0.32448,"NES":0.41194,"nMoreExtreme":51749,"size":10,"leadingEdge":["COPS7A","COPS5","TOR1A","COPS4","COPS3","COPS7B","COPS2","COPS6","GPS1"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_CYTOPLASMIC_STRESS_GRANULE","pval":0.87865,"padj":0.97973,"ES":0.31488,"NES":0.41189,"nMoreExtreme":47759,"size":7,"leadingEdge":["YBX1","DDX1","TIA1","DHX9","SSB"]} {"pathway":"GO_SPHINGOMYELIN_BIOSYNTHETIC_PROCESS","pval":0.87619,"padj":0.97907,"ES":0.30743,"NES":0.41109,"nMoreExtreme":47024,"size":6,"leadingEdge":["SPTLC1","SPTLC2","PEMT","SAMD8","SGMS2"]} {"pathway":"GO_TUBULIN_DEACETYLATION","pval":0.93011,"padj":0.98762,"ES":0.32442,"NES":0.41081,"nMoreExtreme":53108,"size":11,"leadingEdge":["SIRT2","FRY","HDAC6","EP300","BEX4","PRKAA1","NEK3","PRKAA2","FNTA","TADA3","MAPT"]} {"pathway":"GO_ELASTIC_FIBER_ASSEMBLY","pval":0.90402,"padj":0.98417,"ES":0.32101,"NES":0.41003,"nMoreExtreme":50519,"size":9,"leadingEdge":["LOX","MYH11","EMILIN1","FBLN5","ATP7A","MFAP4","TNXB","EFEMP2","THSD4"]} {"pathway":"GO_REGULATION_OF_RIBOSOME_BIOGENESIS","pval":0.95462,"padj":0.99332,"ES":0.32357,"NES":0.41002,"nMoreExtreme":55597,"size":13,"leadingEdge":["RIOK2","BUD23","DIMT1","WDR75","HEATR1","RIOK1","SHQ1","MALSU1","WDR43","UTP15","PTEN","TRMT112"]} {"pathway":"GO_REGULATION_OF_LIPOPHAGY","pval":0.88967,"padj":0.98138,"ES":0.29768,"NES":0.40948,"nMoreExtreme":47075,"size":5,"leadingEdge":["SPTLC1","SPTLC2","SESN2","ADRB2","HTT"]} {"pathway":"GO_HISTONE_H4_R3_METHYLATION","pval":0.87913,"padj":0.97991,"ES":0.30526,"NES":0.40819,"nMoreExtreme":47182,"size":6,"leadingEdge":["PRMT5","PRDM4","PRMT1","PRMT7"]} {"pathway":"GO_MATURATION_OF_SSU_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA_","pval":0.99961,"padj":1,"ES":0.28464,"NES":0.40806,"nMoreExtreme":66359,"size":34,"leadingEdge":["NOP14","RPS16","RPS19","UTP6","BYSL","NOL10","UTP25","HEATR1","RCL1","UTP20","RRP36","KRI1","NGDN","UTP3","MRPS9","UTP4","RPS8","ABT1","UTP23","DHX37","TSR2","FAM207A","RPS14","DCAF13","BMS1","BTRC","TSR1","RPSA","RPS21","RRS1","MRPS11","TBL3"]} {"pathway":"GO_PEROXISOME_FISSION","pval":0.90514,"padj":0.98417,"ES":0.31857,"NES":0.40691,"nMoreExtreme":50582,"size":9,"leadingEdge":["DNM1L","ACOT8","PEX11G","SEC16B","PEX11B","PEX19","PEX11A","MFF"]} {"pathway":"GO_UBIQUITIN_DEPENDENT_ENDOCYTOSIS","pval":0.89245,"padj":0.98267,"ES":0.29542,"NES":0.40638,"nMoreExtreme":47222,"size":5,"leadingEdge":["TSG101","IL10RA","LRSAM1","VPS28"]} {"pathway":"GO_REGULATION_OF_INFLAMMATORY_RESPONSE_TO_WOUNDING","pval":0.96107,"padj":0.9934,"ES":0.27552,"NES":0.40591,"nMoreExtreme":49131,"size":3,"leadingEdge":["GRN","SIGLEC10","AGER"]} {"pathway":"GO_GLYCOLIPID_TRANSPORT","pval":0.89288,"padj":0.98267,"ES":0.29504,"NES":0.40585,"nMoreExtreme":47245,"size":5,"leadingEdge":["PLEKHA8","NPC2","GLTP","RFT1","PSAP"]} {"pathway":"GO_DNA_DEALKYLATION_INVOLVED_IN_DNA_REPAIR","pval":0.91815,"padj":0.987,"ES":0.31914,"NES":0.40516,"nMoreExtreme":51825,"size":10,"leadingEdge":["ALKBH5","ASCC2","ALKBH1","MPG","ASCC3","ASCC1","FTO","ALKBH3","MGMT"]} {"pathway":"GO_REGULATION_OF_CELL_PROJECTION_SIZE","pval":0.89494,"padj":0.98309,"ES":0.29367,"NES":0.40396,"nMoreExtreme":47354,"size":5,"leadingEdge":["XK","EZR","PLS1"]} {"pathway":"GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_NADH_TO_UBIQUINONE","pval":0.99996,"padj":1,"ES":0.26973,"NES":0.40383,"nMoreExtreme":69423,"size":45,"leadingEdge":["NDUFAB1","NDUFS1","NDUFB4","COQ9","NDUFB2","DLD","NDUFB7","NDUFC1","NDUFS8","NDUFS7","PARK7","NDUFB3","NDUFA8","DNAJC15","NDUFA1","NDUFA5","NDUFA10","NDUFA2","NDUFB5","NDUFAF1","NDUFA9","NDUFB10","SNCA","NDUFS6","NDUFB11","NDUFB9","NDUFC2","PINK1","NDUFS2","NDUFV3","NDUFS4","NDUFB6","NDUFB8","NDUFV1","NDUFS5","NDUFA3","NDUFA11","NDUFV2","NDUFB1","NDUFA12","NDUFA6","NDUFA13","NDUFA4"]} {"pathway":"GO_ZINC_ION_IMPORT_ACROSS_PLASMA_MEMBRANE","pval":0.88269,"padj":0.98086,"ES":0.30191,"NES":0.40371,"nMoreExtreme":47373,"size":6,"leadingEdge":["SLC39A14","SLC39A8","SLC39A6","SLC39A12","SLC30A1","SLC39A10"]} {"pathway":"GO_GAS_TRANSPORT","pval":0.89547,"padj":0.98309,"ES":0.29323,"NES":0.40336,"nMoreExtreme":47382,"size":5,"leadingEdge":["IPCEF1","CA2","MYC","CYGB"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MRNA_PROCESSING","pval":0.99758,"padj":1,"ES":0.29233,"NES":0.40135,"nMoreExtreme":63827,"size":26,"leadingEdge":["PAF1","THRAP3","DAZAP1","CIRBP","SNW1","CELF4","RBM3","SNRNP70","CPEB3","PRPF19","NUP98","NCBP2","PRDX6","CCNB1","CDC73","TRA2B","NCBP1","SF3B4","RBMX","TRA2A","LEO1","NUDT21"]} {"pathway":"GO_AEROBIC_ELECTRON_TRANSPORT_CHAIN","pval":0.96971,"padj":0.99631,"ES":0.31375,"NES":0.40087,"nMoreExtreme":57622,"size":15,"leadingEdge":["COX10","COX15","COX6A1","COX7A2L","COX6B1","COX7C","COX4I1","COX7B","AFG1L","COX5B","COX6C","CYCS","COX8A","COX5A","NDUFA4"]} {"pathway":"GO_PEPTIDYL_METHIONINE_MODIFICATION","pval":0.9447,"padj":0.98973,"ES":0.31506,"NES":0.39897,"nMoreExtreme":54492,"size":12,"leadingEdge":["METAP2","NAA25","APOA1","NAA60","NAA35","NAA30","METAP1","NAA15","NAA16","METAP1D","NAA20"]} {"pathway":"GO_CELLULAR_HYPOTONIC_RESPONSE","pval":0.88682,"padj":0.98086,"ES":0.30471,"NES":0.39859,"nMoreExtreme":48203,"size":7,"leadingEdge":["MYLK","TSPO","TRPV4","CAB39","SLC12A6"]} {"pathway":"GO_MEIOTIC_CYTOKINESIS","pval":0.88808,"padj":0.98088,"ES":0.29788,"NES":0.39832,"nMoreExtreme":47662,"size":6,"leadingEdge":["ACTR3","SPIRE1","ACTR2","FMN2","WASHC5"]} {"pathway":"GO_MOTOR_NEURON_APOPTOTIC_PROCESS","pval":0.88822,"padj":0.98088,"ES":0.29775,"NES":0.39815,"nMoreExtreme":47670,"size":6,"leadingEdge":["MAP2K4","ZPR1","MAP3K12","KCNB1","FADD","ADARB1"]} {"pathway":"GO_TRANSLOCATION_OF_MOLECULES_INTO_HOST","pval":0.90756,"padj":0.98435,"ES":0.31127,"NES":0.39759,"nMoreExtreme":50717,"size":9,"leadingEdge":["THOC3","THOC1","THOC5","TCP1","THOC2","THOC6"]} {"pathway":"GO_PYRIMIDINE_NUCLEOTIDE_SALVAGE","pval":0.90069,"padj":0.98417,"ES":0.28903,"NES":0.39758,"nMoreExtreme":47658,"size":5,"leadingEdge":["HDDC2","UCK1","UCK2","UPP1","UCKL1"]} {"pathway":"GO_VOLUNTARY_MUSCULOSKELETAL_MOVEMENT","pval":0.88809,"padj":0.98088,"ES":0.3034,"NES":0.39688,"nMoreExtreme":48272,"size":7,"leadingEdge":["HIPK2","VPS35","XRCC1","ITPR1","VTI1A","MAP1A"]} {"pathway":"GO_REGULATION_OF_LYMPHOID_PROGENITOR_CELL_DIFFERENTIATION","pval":0.88844,"padj":0.98088,"ES":0.30301,"NES":0.39636,"nMoreExtreme":48291,"size":7,"leadingEdge":["HES1","SOS1","ZBTB1","NOTCH1","FLCN","NUDT21"]} {"pathway":"GO_PHOTORECEPTOR_CELL_OUTER_SEGMENT_ORGANIZATION","pval":0.88859,"padj":0.98088,"ES":0.30291,"NES":0.39624,"nMoreExtreme":48299,"size":7,"leadingEdge":["CNGB1","IFT20","NPHP4","AHI1","BBS4"]} {"pathway":"GO_PROTEIN_PEPTIDYL_PROLYL_ISOMERIZATION","pval":0.99949,"padj":1,"ES":0.27686,"NES":0.39503,"nMoreExtreme":66069,"size":33,"leadingEdge":["FKBP4","FKBP7","PPIE","FKBP1A","FKBP5","PPIL2","FKBP3","PIN4","FKBP8","FKBP14","PPIF","PPWD1","NKTR","PTPA","FKBP1B","FKBP9","PIN1","PPIL4","FKBP11","PPIL1","PPIG","FKBP10","CWC27","RANBP2","PPIB","PPIC","PPID","PPIH","FKBP2"]} {"pathway":"GO_TRICUSPID_VALVE_MORPHOGENESIS","pval":0.93784,"padj":0.98783,"ES":0.27632,"NES":0.39349,"nMoreExtreme":48810,"size":4,"leadingEdge":["BMPR1A","TGFBR2","ZFPM1","BMPR2"]} {"pathway":"GO_ATTACHMENT_OF_GPI_ANCHOR_TO_PROTEIN","pval":0.89271,"padj":0.98267,"ES":0.29376,"NES":0.39281,"nMoreExtreme":47911,"size":6,"leadingEdge":["PIGS","PIGU","PIGT","PIGK","PGAP1","GPAA1"]} {"pathway":"GO_CHEMOSENSORY_BEHAVIOR","pval":0.89781,"padj":0.98354,"ES":0.30408,"NES":0.39248,"nMoreExtreme":49469,"size":8,"leadingEdge":["CASR","CFAP69","WFS1","ADCY3","UBR3","SHANK1","CHD7","TRPV1"]} {"pathway":"GO_NUCLEOTIDE_EXCISION_REPAIR_PREINCISION_COMPLEX_STABILIZATION","pval":0.99163,"padj":1,"ES":0.29437,"NES":0.39132,"nMoreExtreme":61715,"size":21,"leadingEdge":["ERCC1","RBX1","ERCC2","RPA3","GTF2H1","GTF2H3","RPA2","CHD1L","RPA1","DDB2","ERCC5","XPA","CUL4A","PARP1","GTF2H2","CUL4B","ERCC3","DDB1"]} {"pathway":"GO_MITOCHONDRIAL_RNA_PROCESSING","pval":0.96363,"padj":0.995,"ES":0.30582,"NES":0.38919,"nMoreExtreme":56719,"size":14,"leadingEdge":["ELAC2","TRIT1","HSD17B10","TRNT1","CDK5RAP1","TRMT5","MTO1","TBRG4","PNPT1","SUPV3L1","TRMT61B","TRMT10C","PUS1"]} {"pathway":"GO_PROTEIN_HETEROTRIMERIZATION","pval":0.93457,"padj":0.98762,"ES":0.30671,"NES":0.38838,"nMoreExtreme":53363,"size":11,"leadingEdge":["WIZ","GNB1","COL1A1","C1QTNF6","NUP54","NUP58","COL6A1","COL6A2"]} {"pathway":"GO_CORPUS_CALLOSUM_MORPHOGENESIS","pval":0.89754,"padj":0.98354,"ES":0.28972,"NES":0.38741,"nMoreExtreme":48170,"size":6,"leadingEdge":["PAFAH1B1","NIN","C12orf57","ZEB2","TSKU","SZT2"]} {"pathway":"GO_COPULATION","pval":0.91139,"padj":0.98539,"ES":0.30275,"NES":0.3867,"nMoreExtreme":50931,"size":9,"leadingEdge":["P2RX1","ACVR2A","PI3","SERPINE2","EDNRB","P2RY1","OXTR","ABAT","ADA"]} {"pathway":"GO_TRNA_5_END_PROCESSING","pval":0.97043,"padj":0.99691,"ES":0.30251,"NES":0.3865,"nMoreExtreme":57665,"size":15,"leadingEdge":["HSD17B10","USP14","POP1","POP4","THG1L","RPP40","SSB","RPP30","RPP38","RPP14","POP5","POP7","TRMT10C","RPP25"]} {"pathway":"GO_EYELID_DEVELOPMENT_IN_CAMERA_TYPE_EYE","pval":0.94624,"padj":0.9905,"ES":0.30516,"NES":0.38643,"nMoreExtreme":54581,"size":12,"leadingEdge":["SRF","SOS1","HDAC1","INHBA","TWIST1","TFAP2A","STRA6","EGFR","OSR2","SOX11","JUN","HDAC2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PROTEIN_IMPORT_INTO_NUCLEUS","pval":0.9232,"padj":0.987,"ES":0.30378,"NES":0.38565,"nMoreExtreme":52110,"size":10,"leadingEdge":["FERMT1","SUFU","RAB23","CD36","MDFIC","ANGPT1","PKIG","PKIA","CHP1","NF1"]} {"pathway":"GO_ESTABLISHMENT_OF_MEIOTIC_SPINDLE_LOCALIZATION","pval":0.94455,"padj":0.98973,"ES":0.2707,"NES":0.38549,"nMoreExtreme":49159,"size":4,"leadingEdge":["MYH9","SPIRE1","FMN2","SPIRE2"]} {"pathway":"GO_PROTEIN_IMPORT_INTO_PEROXISOME_MEMBRANE","pval":0.8995,"padj":0.98394,"ES":0.28811,"NES":0.38525,"nMoreExtreme":48275,"size":6,"leadingEdge":["PEX3","PEX16","PEX5","PEX19","RAB8B"]} {"pathway":"GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND","pval":0.93539,"padj":0.98762,"ES":0.30379,"NES":0.3847,"nMoreExtreme":53410,"size":11,"leadingEdge":["CTNNA1","SRPX","PPP2R1A","HTRA2","INHBA","PPP2R1B","RET","DAPK3","PPP1CA","WWOX","NF1"]} {"pathway":"GO_ELASTIN_CATABOLIC_PROCESS","pval":0.97258,"padj":0.99756,"ES":0.26027,"NES":0.38346,"nMoreExtreme":49719,"size":3,"leadingEdge":["CST3","CELA1"]} {"pathway":"GO_RNA_POLYADENYLATION","pval":0.99996,"padj":1,"ES":0.25601,"NES":0.38329,"nMoreExtreme":69423,"size":45,"leadingEdge":["PAF1","ZC3H3","PABPC1","CPSF1","SNRPA","PAPOLA","ZC3H14","PABPC1L","CSTF2","RNF40","CPEB3","MTPAP","CPSF6","TENT4A","PAPOLG","CPSF3","TENT4B","SYMPK","CCNT1","GRSF1","CDC73","WDR33","CDK9","PNPT1","APP","FIP1L1","TUT1","CPSF7","RNF20","SSU72","TENT2","VIRMA","PCF11","CPSF2","LEO1","NUDT21","AHCYL1","CLP1","CSTF3","HSF1","SUPT5H","CTR9","NELFE","SCAF8","CPEB1"]} {"pathway":"GO_IMMATURE_B_CELL_DIFFERENTIATION","pval":0.89861,"padj":0.98385,"ES":0.29161,"NES":0.38144,"nMoreExtreme":48844,"size":7,"leadingEdge":["ABL1","ATP11C","LRRC8A","ATM","RAG1","IRF2BP2"]} {"pathway":"GO_N_TERMINAL_PROTEIN_AMINO_ACID_MODIFICATION","pval":0.99697,"padj":1,"ES":0.27926,"NES":0.38109,"nMoreExtreme":63510,"size":25,"leadingEdge":["CREBBP","EP300","PPM1A","NAA10","NAA40","METAP2","NAA25","KAT2B","NAA50","NAA60","SOX4","NAA35","NMT1","PPM1B","NAA30","NTMT1","NMT2","METAP1","NAA15","NAA16","METAP1D","NAA20","MAP6D1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_EPIDERMAL_GROWTH_FACTOR_ACTIVATED_RECEPTOR_ACTIVITY","pval":0.9572,"padj":0.9934,"ES":0.30012,"NES":0.3803,"nMoreExtreme":55747,"size":13,"leadingEdge":["GPRC5A","TSG101","PSEN1","CBL","CBLB","ERRFI1","SNX6","VPS25","ZFYVE28","SOCS5","CHMP6","SOCS4","ZGPAT"]} {"pathway":"GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_DUPLEX_UNWINDING","pval":0.99322,"padj":1,"ES":0.2839,"NES":0.38009,"nMoreExtreme":62147,"size":22,"leadingEdge":["RBX1","ERCC2","GTF2H1","GTF2H3","RAD23B","CHD1L","DDB2","XPA","CUL4A","PARP1","RPS27A","GTF2H2","CETN2","UBC","XPC","CUL4B","ERCC3","DDB1","UBB"]} {"pathway":"GO_PEPTIDYL_PROLINE_MODIFICATION","pval":0.99996,"padj":1,"ES":0.25159,"NES":0.37908,"nMoreExtreme":69793,"size":47,"leadingEdge":["FKBP4","P4HA2","FKBP7","PPIE","OGFOD1","FKBP1A","P3H2","FKBP5","PPIL2","FKBP3","PIN4","FKBP8","FKBP14","PPIF","P3H3","PPWD1","NKTR","P3H1","PTPA","FKBP1B","FKBP9","P4HA1","PIN1","EGLN3","PPIL4","FKBP11","EGLN1","PPIL1","PPIG","FKBP10","NTMT1","P4HA3","CWC27","RANBP2"]} {"pathway":"GO_INTERLEUKIN_1_BIOSYNTHETIC_PROCESS","pval":0.91809,"padj":0.987,"ES":0.27555,"NES":0.37904,"nMoreExtreme":48579,"size":5,"leadingEdge":["TYROBP","EGR1","APP","AZU1","AGER"]} {"pathway":"GO_REGULATION_OF_INTERLEUKIN_1_BIOSYNTHETIC_PROCESS","pval":0.91809,"padj":0.987,"ES":0.27555,"NES":0.37904,"nMoreExtreme":48579,"size":5,"leadingEdge":["TYROBP","EGR1","APP","AZU1","AGER"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_BIOSYNTHETIC_PROCESS","pval":0.90593,"padj":0.98417,"ES":0.28268,"NES":0.37799,"nMoreExtreme":48620,"size":6,"leadingEdge":["ABCA7","ITM2A","ITM2C","ITM2B"]} {"pathway":"GO_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_III_PROMOTER","pval":0.94742,"padj":0.99093,"ES":0.29805,"NES":0.37743,"nMoreExtreme":54649,"size":12,"leadingEdge":["TBPL1","GTF3C1","POLR3H","BRF2","TBP","GTF3C3","GTF3C4","BDP1","GTF3C5"]} {"pathway":"GO_CHIASMA_ASSEMBLY","pval":0.91993,"padj":0.987,"ES":0.27431,"NES":0.37734,"nMoreExtreme":48676,"size":5,"leadingEdge":["CCNB1IP1","UBE2B","BRIP1","RNF212","MSH5"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MRNA_PROCESSING","pval":0.99894,"padj":1,"ES":0.27001,"NES":0.37723,"nMoreExtreme":64824,"size":29,"leadingEdge":["PTBP1","SFSWAP","U2AF2","ZC3H14","CELF4","RNF40","HNRNPL","C1QBP","SRSF9","SRSF7","SRSF4","HNRNPA2B1","SRSF6","RBM42","CCNT1","CDK9","BARD1","RBMX","SAP18","SRSF12","RNF20","DYRK1A"]} {"pathway":"GO_POSITIVE_REGULATION_OF_LONG_TERM_NEURONAL_SYNAPTIC_PLASTICITY","pval":0.9521,"padj":0.99283,"ES":0.26449,"NES":0.37665,"nMoreExtreme":49552,"size":4,"leadingEdge":["NEURL1","EPHB2","NPTN"]} {"pathway":"GO_INTRACELLULAR_PROTEIN_TRANSMEMBRANE_TRANSPORT","pval":0.99997,"padj":1,"ES":0.24733,"NES":0.37574,"nMoreExtreme":70337,"size":50,"leadingEdge":["SEC62","SEC63","HSPA5","SEC61A1","TRAM2","SEC61A2","TRAM1","TIMM21","SRP54","LONP2","TIMM44","TIMM50","AKT2","SEC61B","PEX12","GRPEL1","C2CD5","PEX7","DNAJC15","PEX16","PEX6","RTN2","ROMO1","TIMM17B","PEX1","TOMM40","TIMM17A","PEX5","PEX14","SRP9","HSPD1","SRP19","PEX10","ZFAND2B","TOMM40L","PEX13","CHCHD4","GRPEL2","PEX2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_DNA_DAMAGE_CHECKPOINT","pval":0.92155,"padj":0.987,"ES":0.27307,"NES":0.37564,"nMoreExtreme":48762,"size":5,"leadingEdge":["THOC1","THOC5","CHEK2","DDX39B","PPP1R10"]} {"pathway":"GO_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_PROSTATE_GLAND_DEVELOPMENT","pval":0.9269,"padj":0.987,"ES":0.29512,"NES":0.37467,"nMoreExtreme":52319,"size":10,"leadingEdge":["FGFR2","WDR77","FOXA1","NOTCH1","HOXB13","CTNNB1","FEM1B","AR","RXRA","PSAP"]} {"pathway":"GO_PENTOSE_PHOSPHATE_SHUNT","pval":0.95793,"padj":0.9934,"ES":0.2954,"NES":0.37432,"nMoreExtreme":55790,"size":13,"leadingEdge":["DERA","H6PD","TIGAR","PGD","RPIA","G6PD","TKT","PGM2","RBKS","PGAM1","TALDO1","SHPK","RPE"]} {"pathway":"GO_HISTONE_H3_K9_DEMETHYLATION","pval":0.95793,"padj":0.9934,"ES":0.29528,"NES":0.37418,"nMoreExtreme":55790,"size":13,"leadingEdge":["KDM1A","KDM7A","KDM4A","HSF4","KDM4C","KDM3A","KDM3B","KDM4B","HR","JMJD1C","PHF8","KDM4D","PHF2"]} {"pathway":"GO_CHROMATIN_SILENCING_AT_RDNA","pval":0.93762,"padj":0.98783,"ES":0.29525,"NES":0.37388,"nMoreExtreme":53537,"size":11,"leadingEdge":["SIRT2","BAZ2A","SIRT1","SUV39H1","NAA40","RRP8","MBD2","SMARCA5","PHF8","BEND3","PHF2"]} {"pathway":"GO_PROTEIN_GERANYLGERANYLATION","pval":0.91083,"padj":0.98532,"ES":0.27916,"NES":0.37328,"nMoreExtreme":48883,"size":6,"leadingEdge":["RABGGTA","RABGGTB","PGGT1B","FNTA","CHM","CHML"]} {"pathway":"GO_MAINTENANCE_OF_PROTEIN_LOCALIZATION_IN_ENDOPLASMIC_RETICULUM","pval":0.92749,"padj":0.987,"ES":0.29383,"NES":0.37303,"nMoreExtreme":52352,"size":10,"leadingEdge":["HSPA5","KDELR3","KDELR1","ANKRD13C","OS9","KDELR2","RER1","TAPT1","INSIG1","GPAA1"]} {"pathway":"GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MITOCHONDRIAL_MEMBRANE","pval":0.98453,"padj":0.99994,"ES":0.28564,"NES":0.37201,"nMoreExtreme":59900,"size":18,"leadingEdge":["AGK","HSP90AA1","TIMM13","TOMM22","SAMM50","TIMM9","PDCD5","ROMO1","TIMM10","TIMM29","OXA1L","CALM3","MAIP1","COX18","HSPA4","TIMM22","NDUFA13","CALM1"]} {"pathway":"GO_DIAPEDESIS","pval":0.91233,"padj":0.98592,"ES":0.27766,"NES":0.37128,"nMoreExtreme":48964,"size":6,"leadingEdge":["CRKL","CD99L2","ITGA4","FER","CRK"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_NON_MOTILE_CILIUM","pval":0.90623,"padj":0.98417,"ES":0.2834,"NES":0.37071,"nMoreExtreme":49258,"size":7,"leadingEdge":["TULP3","ARL6","BBS4","ZDHHC3","TUB","ARL13B"]} {"pathway":"GO_NUCLEOSIDE_MONOPHOSPHATE_CATABOLIC_PROCESS","pval":0.92682,"padj":0.987,"ES":0.26948,"NES":0.37069,"nMoreExtreme":49041,"size":5,"leadingEdge":["DNPH1","AMPD3","NT5E","HPRT1","NT5M"]} {"pathway":"GO_HYPOTONIC_RESPONSE","pval":0.9181,"padj":0.987,"ES":0.29014,"NES":0.37059,"nMoreExtreme":51306,"size":9,"leadingEdge":["MYLK","TSPO","TRPV4","SLC12A5","CAB39","SLC12A6","ITGA2","OXSR1"]} {"pathway":"GO_GLOBAL_GENOME_NUCLEOTIDE_EXCISION_REPAIR","pval":0.99761,"padj":1,"ES":0.26977,"NES":0.37037,"nMoreExtreme":63829,"size":26,"leadingEdge":["ERCC1","RBX1","ERCC2","GTF2H1","GTF2H3","RAD23B","USP45","CHD1L","DDB2","XPA","CUL4A","PARP1","RPS27A","GTF2H2","CETN2","UBC","XPC","RNF111","CUL4B","ERCC3","DDB1","UBB","ERCC4"]} {"pathway":"GO_OPTIC_CUP_MORPHOGENESIS_INVOLVED_IN_CAMERA_TYPE_EYE_DEVELOPMENT","pval":0.91328,"padj":0.98626,"ES":0.27691,"NES":0.37028,"nMoreExtreme":49015,"size":6,"leadingEdge":["WNT5A","ARID1A","TFAP2A","SOX11","ALDH1A3","PHACTR4"]} {"pathway":"GO_MUCOSAL_ASSOCIATED_LYMPHOID_TISSUE_DEVELOPMENT","pval":0.9073,"padj":0.98435,"ES":0.28266,"NES":0.36974,"nMoreExtreme":49316,"size":7,"leadingEdge":["ID2","ARTN","RET","STAT5B","FOXL1","ADA","TOX"]} {"pathway":"GO_RNA_INTERFERENCE","pval":0.96509,"padj":0.99537,"ES":0.29025,"NES":0.36937,"nMoreExtreme":56805,"size":14,"leadingEdge":["DICER1","DROSHA","TSNAX","NRDE2","AGO2","XPO5","DHX9","MRPL44","TARBP2","CELF1","HENMT1","CLP1","PRKRA"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_STRESS","pval":0.94884,"padj":0.99138,"ES":0.29168,"NES":0.36936,"nMoreExtreme":54731,"size":12,"leadingEdge":["SIRT2","NCK2","DNAJB1","VHL","TMBIM6","BAG3","IMPACT","NCK1","CITED2","HIF1AN","JUN"]} {"pathway":"GO_UMP_BIOSYNTHETIC_PROCESS","pval":0.91878,"padj":0.987,"ES":0.28909,"NES":0.36926,"nMoreExtreme":51344,"size":9,"leadingEdge":["CAD","UPRT","DHODH","UMPS","UCK1","UCK2","CMPK1","UPP1","UCKL1"]} {"pathway":"GO_RIBOSOMAL_LARGE_SUBUNIT_EXPORT_FROM_NUCLEUS","pval":0.91883,"padj":0.987,"ES":0.28893,"NES":0.36905,"nMoreExtreme":51347,"size":9,"leadingEdge":["XPO1","BCCIP","NUP88","RAN","ZNF593","NMD3","RRS1","NPM1","SDAD1"]} {"pathway":"GO_ACETYL_COA_METABOLIC_PROCESS","pval":0.9082,"padj":0.9845,"ES":0.28172,"NES":0.36851,"nMoreExtreme":49365,"size":7,"leadingEdge":["ACACB","MVK","HMGCS1","PMVK","MVD","FASN"]} {"pathway":"GO_MODULATION_OF_AGE_RELATED_BEHAVIORAL_DECLINE","pval":0.91463,"padj":0.98699,"ES":0.27556,"NES":0.36847,"nMoreExtreme":49087,"size":6,"leadingEdge":["PICALM","PSEN1","DKK1","APP","PRNP","AGER"]} {"pathway":"GO_REGULATION_OF_CELLULAR_CARBOHYDRATE_CATABOLIC_PROCESS","pval":0.91946,"padj":0.987,"ES":0.28794,"NES":0.36779,"nMoreExtreme":51382,"size":9,"leadingEdge":["TIGAR","GSK3A","PPP1R3D","SCARB2","PHKG2","PGAM1","PPP1CA","PPP1R3B"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CHROMATIN_SILENCING","pval":0.94914,"padj":0.99155,"ES":0.29032,"NES":0.36764,"nMoreExtreme":54748,"size":12,"leadingEdge":["SIRT1","TRIM28","DNMT1","MORC2","PPHLN1","SETDB1","TASOR","SIN3A","ATF7IP","RESF1","MPHOSPH8","MIER1"]} {"pathway":"GO_GLYCOSYLCERAMIDE_CATABOLIC_PROCESS","pval":0.90967,"padj":0.98498,"ES":0.2803,"NES":0.36665,"nMoreExtreme":49445,"size":7,"leadingEdge":["GALC","GBA2","GLA","PRKCD","GBA","PSAP","NAGA"]} {"pathway":"GO_RESPONSE_TO_FLUORIDE","pval":0.96013,"padj":0.9934,"ES":0.25654,"NES":0.36533,"nMoreExtreme":49970,"size":4,"leadingEdge":["COL1A1","FOXO1","ATG7","FIS1"]} {"pathway":"GO_TRANSLATIONAL_READTHROUGH","pval":0.91378,"padj":0.98655,"ES":0.28273,"NES":0.36492,"nMoreExtreme":50349,"size":8,"leadingEdge":["SEPSECS","EEFSEC","SECISBP2L","EIF4A3","PSTK","TRNAU1AP","SECISBP2","SELENOT"]} {"pathway":"GO_REGULATION_OF_MICROTUBULE_NUCLEATION","pval":0.91927,"padj":0.987,"ES":0.27163,"NES":0.36322,"nMoreExtreme":49336,"size":6,"leadingEdge":["RANGRF","EML2","MECP2","HSPA1B","HSPA1A","DCTN1"]} {"pathway":"GO_MOTOR_BEHAVIOR","pval":0.91927,"padj":0.987,"ES":0.27163,"NES":0.36322,"nMoreExtreme":49336,"size":6,"leadingEdge":["C12orf57","GRPR","PRKAA1","ADARB1","DPP4","DCTN1"]} {"pathway":"GO_IRON_SULFUR_CLUSTER_ASSEMBLY","pval":0.99335,"padj":1,"ES":0.27118,"NES":0.36306,"nMoreExtreme":62155,"size":22,"leadingEdge":["CIAPIN1","NUBP2","HSCB","CIAO3","NUBP1","GLRX3","HSPA9","ISCA1","ISCU","CIAO1","NUBPL","MMS19","FXN","ISCA2","CIAO2B","CIAO2A","NFU1","BOLA2B","IBA57","BOLA2","NDOR1"]} {"pathway":"GO_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER","pval":0.9982,"padj":1,"ES":0.2625,"NES":0.36259,"nMoreExtreme":64183,"size":27,"leadingEdge":["PAF1","ZMYND11","CDK13","SUPT16H","ELL","EZH2","RECQL5","SUPT6H","RNF8","GTF2F1","EAPP","CDC73","CDK9","RTF1","WDR61","BRD4","HNRNPU","ELOC","RNF168","LEO1","CDK12","NELFA","GTF2F2","NELFB","CTR9","NELFE","SUPT4H1"]} {"pathway":"GO_PROTECTION_FROM_NON_HOMOLOGOUS_END_JOINING_AT_TELOMERE","pval":0.93126,"padj":0.98762,"ES":0.28492,"NES":0.36171,"nMoreExtreme":52565,"size":10,"leadingEdge":["ERCC1","XRCC1","TFIP11","ACD","DCLRE1B","TERF2","DCLRE1C","TERF2IP","ERCC4"]} {"pathway":"GO_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX_ASSEMBLY","pval":0.93131,"padj":0.98762,"ES":0.28481,"NES":0.36157,"nMoreExtreme":52568,"size":10,"leadingEdge":["TM9SF4","ATPAF1","CCDC115","OXA1L","VMA21","FMC1","ATP23","ATPAF2","TMEM70"]} {"pathway":"GO_REGULATION_OF_HISTONE_UBIQUITINATION","pval":0.93144,"padj":0.98762,"ES":0.28456,"NES":0.36126,"nMoreExtreme":52575,"size":10,"leadingEdge":["KDM1A","WDR70","RNF40","UBR5","CDK9","TRIP12","RNF20","OTUB1","UBE2N","CTR9"]} {"pathway":"GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION","pval":0.99996,"padj":1,"ES":0.24164,"NES":0.36053,"nMoreExtreme":69184,"size":44,"leadingEdge":["PAF1","ZMYND11","CDK13","THOC1","CCNT2","CCNK","SUPT16H","THOC5","HTATSF1","ELL","EZH2","RECQL5","SUPT6H","RNF8","TSFM","GTF2F1","ELL3","CCNT1","EAPP","CDC73","CDK9","RTF1","WDR61","BRD4","HNRNPU","ELOC","CCAR2","ZNF326","RNF168","LEO1","CDK12","TCEA2","ALYREF","NELFA","GTF2F2","NELFB","SUPT5H","DDX39B","LDB1","CTR9","NELFE","HMGN1","SUPT4H1","ERCC6"]} {"pathway":"GO_TRNA_METHYLATION","pval":0.99982,"padj":1,"ES":0.24658,"NES":0.35978,"nMoreExtreme":67605,"size":38,"leadingEdge":["NSUN2","METTL1","TARBP1","TRMT11","FTSJ1","HSD17B10","METTL2A","TRMT6","TRMT1","TRDMT1","THADA","TRMT1L","TRMT13","METTL8","TRMT5","GTPBP3","THUMPD3","MTO1","TRMO","ALKBH8","THUMPD2","TRMT10A","TRMT44","WDR4","TYW3","METTL2B","TRMT10B","TRMT61A","LCMT2","TRMT61B","TRMT112","TRMT10C","NSUN3","TRMT12","BCDIN3D"]} {"pathway":"GO_RNA_CAPPING","pval":0.99962,"padj":1,"ES":0.25082,"NES":0.35958,"nMoreExtreme":66360,"size":34,"leadingEdge":["POLR2J","MNAT1","POLR2B","NCBP3","POLR2E","POLR2F","RNMT","POLR2C","ERCC2","POLR2I","GTF2H1","GTF2H3","RNGTT","NCBP2","GTF2F1","CDK7","CCNH","NCBP1","CMTR1","TGS1","POLR2D","GTF2H2","POLR2K","ERCC3","POLR2H","POLR2G","RAMAC","POLR2L","CMTR2","POLR2A","GTF2F2","SUPT5H"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_RNA_POLYMERASE_II_REGULATORY_REGION_SEQUENCE_SPECIFIC_DNA_BINDING","pval":0.92282,"padj":0.987,"ES":0.26865,"NES":0.35923,"nMoreExtreme":49527,"size":6,"leadingEdge":["FBXW7","HAND1","ZNF593","TAF1","DDIT3","TMSB4X"]} {"pathway":"GO_ACTIVATION_OF_STORE_OPERATED_CALCIUM_CHANNEL_ACTIVITY","pval":0.93754,"padj":0.98783,"ES":0.261,"NES":0.35902,"nMoreExtreme":49608,"size":5,"leadingEdge":["STIM2","CRACR2A","STIM1","PLCG2","STIMATE"]} {"pathway":"GO_POSITIVE_REGULATION_OF_STORE_OPERATED_CALCIUM_CHANNEL_ACTIVITY","pval":0.93754,"padj":0.98783,"ES":0.261,"NES":0.35902,"nMoreExtreme":49608,"size":5,"leadingEdge":["STIM2","CRACR2A","STIM1","PLCG2","STIMATE"]} {"pathway":"GO_POSITIVE_REGULATION_OF_RECEPTOR_RECYCLING","pval":0.95999,"padj":0.9934,"ES":0.28326,"NES":0.35894,"nMoreExtreme":55910,"size":13,"leadingEdge":["VAMP3","NSF","PSEN1","EPS15","BVES","RAB29","ECE1","SNCA","NSG1","SCRIB","ANXA2","ARAP1","INPP5F"]} {"pathway":"GO_NEURON_NEURON_SYNAPTIC_TRANSMISSION","pval":0.93773,"padj":0.98783,"ES":0.26088,"NES":0.35887,"nMoreExtreme":49618,"size":5,"leadingEdge":["KIF1B","VDAC3","TMOD2","PTEN","VDAC1"]} {"pathway":"GO_GLYCOSIDE_CATABOLIC_PROCESS","pval":0.9242,"padj":0.987,"ES":0.28033,"NES":0.35806,"nMoreExtreme":51647,"size":9,"leadingEdge":["FUCA2","GBA2","GLA","ABHD10","MYORG","GUSB","GBA","FUCA1","NAGA"]} {"pathway":"GO_PEPTIDYL_ARGININE_N_METHYLATION","pval":0.93261,"padj":0.98762,"ES":0.2818,"NES":0.35776,"nMoreExtreme":52641,"size":10,"leadingEdge":["NDUFAF7","PRMT5","PRMT1","PRMT7","FBXO11","CARM1","PRMT2","PRMT9","PRMT3","PRMT6"]} {"pathway":"GO_REGULATION_OF_MITOCHONDRIAL_TRANSLATION","pval":0.99703,"padj":1,"ES":0.26211,"NES":0.35768,"nMoreExtreme":63514,"size":25,"leadingEdge":["ALKBH1","UQCC1","MTG2","CDK5RAP1","C1QBP","MRPS27","NSUN4","FASTKD2","TSFM","FASTKD3","UQCC2","LRPPRC","MTG1","RMND1","MALSU1","RPUSD3","RPUSD4","TRUB2","TRMT10C","NSUN3","SHMT2","NGRN","COA3"]} {"pathway":"GO_PEPTIDYL_ARGININE_METHYLATION","pval":0.95125,"padj":0.99277,"ES":0.28184,"NES":0.3569,"nMoreExtreme":54870,"size":12,"leadingEdge":["NDUFAF7","PRMT5","PRDM4","PRMT1","PRMT7","FBXO11","CARM1","PRMT2","PRMT9","COPRS","PRMT3","PRMT6"]} {"pathway":"GO_TRNA_WOBBLE_URIDINE_MODIFICATION","pval":0.98195,"padj":0.99935,"ES":0.27585,"NES":0.35674,"nMoreExtreme":59338,"size":17,"leadingEdge":["ELP1","TRMU","ELP4","MOCS3","GTPBP3","ELP3","ELP2","MTO1","ALKBH8","CTU1","DPH3","ELP6","URM1","ELP5","CTU2"]} {"pathway":"GO_REGULATION_OF_CYCLIC_NUCLEOTIDE_PHOSPHODIESTERASE_ACTIVITY","pval":0.91734,"padj":0.987,"ES":0.27254,"NES":0.35651,"nMoreExtreme":49862,"size":7,"leadingEdge":["AIP","EGLN1","CALM2","CALM3","MAPK7","CALM1","RACK1"]} {"pathway":"GO_PROTON_TRANSPORTING_V_TYPE_ATPASE_COMPLEX_ASSEMBLY","pval":0.96616,"padj":0.99537,"ES":0.25028,"NES":0.35641,"nMoreExtreme":50284,"size":4,"leadingEdge":["TM9SF4","CCDC115","VMA21"]} {"pathway":"GO_SPLICEOSOMAL_CONFORMATIONAL_CHANGES_TO_GENERATE_CATALYTIC_CONFORMATION","pval":0.93964,"padj":0.98783,"ES":0.25902,"NES":0.3563,"nMoreExtreme":49719,"size":5,"leadingEdge":["XAB2","PRPF19","SNRNP200","PRPF18"]} {"pathway":"GO_PHOSPHORYLATION_OF_RNA_POLYMERASE_II_C_TERMINAL_DOMAIN","pval":0.93319,"padj":0.98762,"ES":0.28064,"NES":0.35628,"nMoreExtreme":52674,"size":10,"leadingEdge":["CDK13","CCNK","GTF2H1","GTF2H3","PPIL4","CDK9","BRD4"]} {"pathway":"GO_RIBOSOMAL_LARGE_SUBUNIT_BIOGENESIS","pval":1,"padj":1,"ES":0.22521,"NES":0.35526,"nMoreExtreme":73760,"size":67,"leadingEdge":["LAS1L","RPL26L1","NOP16","MRTO4","WDR18","NLE1","RPLP0","PES1","SNU13","RPL3","NOP53","GTPBP4","FTSJ3","NOP2","PAK1IP1","MDN1","BRIX1","RPL24","ZNHIT6","EBNA1BP2","FASTKD2","GTF3A","RPL5","AAMP","PPAN","TRAF7","DHX30","NIP7","WDR74","RPL35","RSL24D1","WDR12","URB1","RPL11","NVL","NHP2","RPL7L1","RPL10","RPL7","SURF6","RPL7A","LTO1","HEATR3","MALSU1","RPL26","NOL9","MRPL1","RSL1D1","RPL38","ZNF622","NWD2","MRPL11","RRS1","NPM1","DDX28","RPL35A","RPL14","NOC2L","RPF2","RPL12","RPL23A","SDAD1","RPL10A"]} {"pathway":"GO_CALCIUM_ION_IMPORT_INTO_CYTOSOL","pval":0.92073,"padj":0.987,"ES":0.27402,"NES":0.35368,"nMoreExtreme":50732,"size":8,"leadingEdge":["FYN","ATP2B4","SLC8A3","TRPM2","CACNA2D1","PRNP","TRPV1","FAM155A"]} {"pathway":"GO_REGULATION_OF_MRNA_3_END_PROCESSING","pval":0.99821,"padj":1,"ES":0.25575,"NES":0.35327,"nMoreExtreme":64184,"size":27,"leadingEdge":["PAF1","SNRPA","PAPOLA","ZC3H14","RNF40","CPEB3","CPSF6","NCBP2","CCNT1","CCNB1","CDC73","CDK9","NCBP1","BARD1","CPSF7","RNF20","VIRMA","LEO1","NUDT21","AHCYL1","DHX36","HSF1","ZFP36L1","SUPT5H","CTR9","NELFE","CPEB1"]} {"pathway":"GO_REGULATION_OF_CEREBELLAR_GRANULE_CELL_PRECURSOR_PROLIFERATION","pval":0.92802,"padj":0.98705,"ES":0.26408,"NES":0.35312,"nMoreExtreme":49806,"size":6,"leadingEdge":["GLI2","GLI1","SMO","EGF"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CEREBELLAR_GRANULE_CELL_PRECURSOR_PROLIFERATION","pval":0.92802,"padj":0.98705,"ES":0.26408,"NES":0.35312,"nMoreExtreme":49806,"size":6,"leadingEdge":["GLI2","GLI1","SMO","EGF"]} {"pathway":"GO_RESPONSE_TO_HYPOBARIC_HYPOXIA","pval":0.94234,"padj":0.98878,"ES":0.25656,"NES":0.35292,"nMoreExtreme":49862,"size":5,"leadingEdge":["DNM1L","IREB2","ADAM15","HSF1","FIS1"]} {"pathway":"GO_TRNA_5_LEADER_REMOVAL","pval":0.94336,"padj":0.98932,"ES":0.27818,"NES":0.35227,"nMoreExtreme":53865,"size":11,"leadingEdge":["POP1","POP4","RPP40","SSB","RPP30","RPP38","RPP14","POP5","POP7","RPP25"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MRNA_3_END_PROCESSING","pval":0.92751,"padj":0.987,"ES":0.27516,"NES":0.35146,"nMoreExtreme":51832,"size":9,"leadingEdge":["ZC3H14","RNF40","CCNT1","CDK9","BARD1","RNF20","SUPT5H","CTR9","NELFE"]} {"pathway":"GO_SPHINGOID_BIOSYNTHETIC_PROCESS","pval":0.94391,"padj":0.9896,"ES":0.27693,"NES":0.35068,"nMoreExtreme":53896,"size":11,"leadingEdge":["SPHK2","ACER3","SPTLC1","SPTLC2","ASAH1","SPTLC3","SPHK1","ACER2","GBA","ASAH2","ASAH2B"]} {"pathway":"GO_ENDONUCLEOLYTIC_CLEAVAGE_INVOLVED_IN_RRNA_PROCESSING","pval":0.94429,"padj":0.98973,"ES":0.2761,"NES":0.34963,"nMoreExtreme":53918,"size":11,"leadingEdge":["NOP14","RCL1","UTP20","KRI1","ABT1","UTP23","NOL9","RPSA","RPS21","RRS1"]} {"pathway":"GO_MOLYBDOPTERIN_COFACTOR_BIOSYNTHETIC_PROCESS","pval":0.92262,"padj":0.987,"ES":0.26722,"NES":0.34955,"nMoreExtreme":50149,"size":7,"leadingEdge":["MOCOS","MOCS3","MOCS1","MBIP","MOCS2","GPHN"]} {"pathway":"GO_COLLAGEN_ACTIVATED_TYROSINE_KINASE_RECEPTOR_SIGNALING_PATHWAY","pval":0.92882,"padj":0.98746,"ES":0.27297,"NES":0.34866,"nMoreExtreme":51905,"size":9,"leadingEdge":["COL1A1","COL4A2","UBASH3B","DDR2","SYK","COL4A1","COL4A5","COL4A6","DDR1"]} {"pathway":"GO_REGULATION_OF_WOUND_HEALING_SPREADING_OF_EPIDERMAL_CELLS","pval":0.92496,"padj":0.987,"ES":0.26513,"NES":0.34681,"nMoreExtreme":50276,"size":7,"leadingEdge":["CLASP1","RREB1","PHLDB2","CLASP2","PTEN","MTOR","MIR221"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INTEGRIN_MEDIATED_SIGNALING_PATHWAY","pval":0.93376,"padj":0.98762,"ES":0.25904,"NES":0.34639,"nMoreExtreme":50114,"size":6,"leadingEdge":["LIMS2","LOXL3","CD63","DMTN","FLNA","EMP2"]} {"pathway":"GO_IRES_DEPENDENT_VIRAL_TRANSLATIONAL_INITIATION","pval":0.93776,"padj":0.98783,"ES":0.27209,"NES":0.34543,"nMoreExtreme":52932,"size":10,"leadingEdge":["PTBP1","EIF3D","EIF3B","EIF3A","SSB","DENR","EIF2D"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS","pval":0.92697,"padj":0.987,"ES":0.2665,"NES":0.34398,"nMoreExtreme":51076,"size":8,"leadingEdge":["FCGR2B","IL12B","PSMA1","SELENOS","IL10","PSMB4","IL20RB"]} {"pathway":"GO_DIPEPTIDE_TRANSMEMBRANE_TRANSPORT","pval":0.97441,"padj":0.9981,"ES":0.24155,"NES":0.34397,"nMoreExtreme":50713,"size":4,"leadingEdge":["CA2","SLC7A11","SLC15A2","SLC26A6"]} {"pathway":"GO_FORMATION_OF_CYTOPLASMIC_TRANSLATION_INITIATION_COMPLEX","pval":0.96777,"padj":0.99587,"ES":0.27007,"NES":0.34369,"nMoreExtreme":56963,"size":14,"leadingEdge":["EIF3I","EIF3L","EIF3D","EIF3J","EIF3E","EIF3B","EIF3A","EIF3G","EIF3H","EIF3M","EIF3F","EIF3K","EIF3C"]} {"pathway":"GO_REGULATION_OF_STORE_OPERATED_CALCIUM_CHANNEL_ACTIVITY","pval":0.9286,"padj":0.98741,"ES":0.26103,"NES":0.34144,"nMoreExtreme":50474,"size":7,"leadingEdge":["STIM2","CRACR2A","UBQLN1","STIM1","PLA2G6","PLCG2","STIMATE"]} {"pathway":"GO_REGULATION_OF_RNA_POLYMERASE_II_REGULATORY_REGION_SEQUENCE_SPECIFIC_DNA_BINDING","pval":0.95449,"padj":0.99332,"ES":0.26874,"NES":0.34031,"nMoreExtreme":55057,"size":12,"leadingEdge":["ZMPSTE24","EP300","FBXW7","HAND1","LIF","ZNF593","TAF1","NSD1","DDIT3","ZBTB7C","DDRGK1","TMSB4X"]} {"pathway":"GO_MATURE_RIBOSOME_ASSEMBLY","pval":0.93874,"padj":0.98783,"ES":0.25436,"NES":0.34013,"nMoreExtreme":50381,"size":6,"leadingEdge":["C1QBP","NSUN4","SBDS","EFL1"]} {"pathway":"GO_POLYADENYLATION_DEPENDENT_SNORNA_3_END_PROCESSING","pval":0.93928,"padj":0.98783,"ES":0.25386,"NES":0.33945,"nMoreExtreme":50410,"size":6,"leadingEdge":["EXOSC5","EXOSC3","EXOSC2","PARN"]} {"pathway":"GO_C_TERMINAL_PROTEIN_AMINO_ACID_MODIFICATION","pval":0.94736,"padj":0.99093,"ES":0.26805,"NES":0.33944,"nMoreExtreme":54093,"size":11,"leadingEdge":["ATG5","ATG16L1","GPLD1","TTL","ICMT","AGTPBP1","ATG12","WIPI2","LCMT2","ATG7","LCMT1"]} {"pathway":"GO_PRODUCTION_OF_SIRNA_INVOLVED_IN_RNA_INTERFERENCE","pval":0.93388,"padj":0.98762,"ES":0.26539,"NES":0.33898,"nMoreExtreme":52188,"size":9,"leadingEdge":["DICER1","DROSHA","TSNAX","AGO2","MRPL44","TARBP2","HENMT1"]} {"pathway":"GO_ATF6_MEDIATED_UNFOLDED_PROTEIN_RESPONSE","pval":0.9407,"padj":0.98812,"ES":0.26604,"NES":0.33774,"nMoreExtreme":53098,"size":10,"leadingEdge":["MBTPS2","HSPA5","XBP1","WFS1","ATF6","MBTPS1","HSP90B1","DDIT3","CALR"]} {"pathway":"GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_EXONUCLEOLYTIC_3_5_","pval":0.94072,"padj":0.98812,"ES":0.26591,"NES":0.33759,"nMoreExtreme":53099,"size":10,"leadingEdge":["EXOSC7","EXOSC5","EXOSC3","EXOSC8","EXOSC9","EXOSC2","DIS3L2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION","pval":0.999,"padj":1,"ES":0.24144,"NES":0.33731,"nMoreExtreme":64828,"size":29,"leadingEdge":["PAF1","CDK13","THOC1","CCNT2","CCNK","SUPT16H","THOC5","ELL","SUPT6H","GTF2F1","ELL3","CCNT1","EAPP","CDC73","CDK9","RTF1","WDR61","BRD4","ELOC","LEO1","CDK12","ALYREF","GTF2F2","SUPT5H","DDX39B","CTR9","HMGN1","SUPT4H1","ERCC6"]} {"pathway":"GO_LATE_ENDOSOME_TO_VACUOLE_TRANSPORT_VIA_MULTIVESICULAR_BODY_SORTING_PATHWAY","pval":0.9324,"padj":0.98762,"ES":0.26053,"NES":0.33628,"nMoreExtreme":51375,"size":8,"leadingEdge":["LEPROTL1","VPS25","VPS36","TMEM50B","SNF8","VPS28","TMEM50A","LEPROT"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_DIFFERENTIATION","pval":0.93281,"padj":0.98762,"ES":0.25997,"NES":0.33555,"nMoreExtreme":51398,"size":8,"leadingEdge":["FOXJ2","JAG1","ID1","ACVRL1","ZEB1","XDH","NOTCH4","S1PR3"]} {"pathway":"GO_MITOCHONDRIAL_TRANSLATION","pval":1,"padj":1,"ES":0.19816,"NES":0.33504,"nMoreExtreme":82211,"size":133,"leadingEdge":["LARS2","MRPS10","MRPL43","GATB","MRPS35","MRPS24","IARS2","MRPS34","MRPL22","NOA1","MTIF2","MRPL28","MRPS33","MRPS18A","ALKBH1","UQCC1","MTG2","CDK5RAP1","MRPS31","EARS2","MRPL4","MRPL32","C1QBP","MRPL27","MRPL51","MTRF1L","MRPL18","MRPL2","MRPS30","MRPS27","MRPL3","MRPL19","MRPL37","WARS2","MRPS15","NSUN4","DARS2","FASTKD2","MRPS14","MTRF1","MTIF3","MTERF4","MRPS2","TSFM","FASTKD3","AARS2","MRPS7","MRPS26","MRPS12","MRPL34","QRSL1","MRPS25","PTCD3","MRPL35","ERAL1","DAP3","MRPS36","MRPL44","MRPS9","MRPL47","MRPL50","UQCC2","MRPL15","LRPPRC","YARS2","MRPL24","TARS2","MRPL9","MRPS5","RARS2","MRPS28","MRRF","MTG1","MRPL49","MRPL39","OXA1L","RMND1","MTERF3","MALSU1","RPUSD3","MRPL17","MRPL10","MRPL55","MRPS18C","GFM2","RPUSD4","MRPL16","TRUB2","MRPL58","GFM1","MRPL1","MRPL36","MRPL13","CHCHD1","MRPL52","MRPL57","TRMT10C","MRPL11","MRPS22","MRPL48","AURKAIP1","NSUN3","TUFM","GADD45GIP1","MRPL14","MRPS23","MRPS11","MRPL41","MRPS16","SHMT2","NGRN","MRPL54","COA3","MRPL30","MRPL40"]} {"pathway":"GO_SOMITE_ROSTRAL_CAUDAL_AXIS_SPECIFICATION","pval":0.93504,"padj":0.98762,"ES":0.25499,"NES":0.33355,"nMoreExtreme":50824,"size":7,"leadingEdge":["TMED2","EPB41L5","SMAD4","KDM6A","TBX6"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER","pval":0.94258,"padj":0.98878,"ES":0.26225,"NES":0.33294,"nMoreExtreme":53204,"size":10,"leadingEdge":["EZH2","RECQL5","RNF8","EAPP","HNRNPU","RNF168","NELFA","NELFB","NELFE","SUPT4H1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION","pval":0.94974,"padj":0.99189,"ES":0.26226,"NES":0.33211,"nMoreExtreme":54229,"size":11,"leadingEdge":["EZH2","RECQL5","RNF8","EAPP","HNRNPU","RNF168","NELFA","NELFB","SUPT5H","NELFE","SUPT4H1"]} {"pathway":"GO_REGULATION_OF_MRNA_POLYADENYLATION","pval":0.9798,"padj":0.99901,"ES":0.25559,"NES":0.32835,"nMoreExtreme":58692,"size":16,"leadingEdge":["SNRPA","ZC3H14","RNF40","CPEB3","CPSF6","CCNT1","CDK9","CPSF7","RNF20","VIRMA","NUDT21","HSF1","SUPT5H","CTR9","NELFE","CPEB1"]} {"pathway":"GO_OLIGOSACCHARIDE_LIPID_INTERMEDIATE_BIOSYNTHETIC_PROCESS","pval":0.99088,"padj":1,"ES":0.24865,"NES":0.32826,"nMoreExtreme":61250,"size":20,"leadingEdge":["ALG1","ALG9","ALG6","ALG13","DHDDS","ALG2","SRD5A3","MPDU1","ALG10","NUS1","ALG8","DOLPP1","MVD","DPAGT1","ALG14","DOLK","ALG10B","ALG12"]} {"pathway":"GO_MATURATION_OF_LSU_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA_","pval":0.9654,"padj":0.99537,"ES":0.25897,"NES":0.32817,"nMoreExtreme":56225,"size":13,"leadingEdge":["PES1","GTPBP4","FTSJ3","ZNHIT6","RPL35","WDR12","URB1","RPL7L1","RPL7","NOL9"]} {"pathway":"GO_REGULATION_OF_INTEGRIN_MEDIATED_SIGNALING_PATHWAY","pval":0.95747,"padj":0.9934,"ES":0.25913,"NES":0.32814,"nMoreExtreme":55229,"size":12,"leadingEdge":["CTNNA1","LIMS2","TIMP1","BST1","LOXL3","ITGB1BP1","CD63","DMTN","PRKD1","FLNA","PHACTR4","EMP2"]} {"pathway":"GO_RNA_SECONDARY_STRUCTURE_UNWINDING","pval":0.93898,"padj":0.98783,"ES":0.25267,"NES":0.32612,"nMoreExtreme":51738,"size":8,"leadingEdge":["AGO1","AGO2","AGO3","AGO4","DHX9","DHX36","DDX39B","DDX3X"]} {"pathway":"GO_MICROTUBULE_NUCLEATION","pval":0.9978,"padj":1,"ES":0.23683,"NES":0.32515,"nMoreExtreme":63841,"size":26,"leadingEdge":["RANBP9","TUBG2","NDE1","CLASP1","NIN","CEP192","RANGRF","SLAIN2","EML2","TUBGCP3","AKAP9","TUBGCP6","TUBGCP2","TUBG1","TUBGCP4","CSNK1D","CENPJ","CLASP2","NDEL1","GOLGA2","MECP2"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_CILIARY_MEMBRANE","pval":0.9462,"padj":0.9905,"ES":0.25601,"NES":0.32502,"nMoreExtreme":53408,"size":10,"leadingEdge":["RABEP1","TULP3","GGA1","RAB29","ARL3","LZTFL1","TUB","ARL13B","EFCAB7","BBIP1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MRNA_3_END_PROCESSING","pval":0.95257,"padj":0.99288,"ES":0.25552,"NES":0.32357,"nMoreExtreme":54391,"size":11,"leadingEdge":["PAF1","CPEB3","NCBP2","CCNB1","CDC73","NCBP1","LEO1","NUDT21","DHX36","HSF1","CPEB1"]} {"pathway":"GO_PEPTIDYL_PROLINE_HYDROXYLATION","pval":0.96633,"padj":0.99537,"ES":0.25512,"NES":0.32328,"nMoreExtreme":56279,"size":13,"leadingEdge":["P4HA2","OGFOD1","P3H2","P3H3","P3H1","P4HA1","EGLN3","EGLN1","P4HA3","CRTAP","P4HTM","P4HB"]} {"pathway":"GO_UV_DAMAGE_EXCISION_REPAIR","pval":0.95271,"padj":0.99288,"ES":0.25521,"NES":0.32318,"nMoreExtreme":54399,"size":11,"leadingEdge":["ERCC1","SIRT1","ACTR5","INO80","DDB2","XPA","XPC","CUL4B","DDB1"]} {"pathway":"GO_RRNA_BASE_METHYLATION","pval":0.94791,"padj":0.99093,"ES":0.25352,"NES":0.32185,"nMoreExtreme":53505,"size":10,"leadingEdge":["BUD23","NSUN5P2","NOP2","EMG1","METTL16","NSUN5"]} {"pathway":"GO_TELOMERE_MAINTENANCE_IN_RESPONSE_TO_DNA_DAMAGE","pval":0.96659,"padj":0.99537,"ES":0.25395,"NES":0.3218,"nMoreExtreme":56294,"size":13,"leadingEdge":["ERCC1","XRCC1","RIF1","TFIP11","APEX1","ACD","DCLRE1B","TERF2"]} {"pathway":"GO_GOLGI_TO_LYSOSOME_TRANSPORT","pval":0.94236,"padj":0.98878,"ES":0.24919,"NES":0.32163,"nMoreExtreme":51924,"size":8,"leadingEdge":["EHD3","CCDC91","RBSN","AP1G1","GAK","ANKFY1","LAMP1","AP4M1"]} {"pathway":"GO_PROTEIN_COFACTOR_LINKAGE","pval":0.94928,"padj":0.99156,"ES":0.25058,"NES":0.31813,"nMoreExtreme":53582,"size":10,"leadingEdge":["NDUFAB1","CTH","LIAS","GAD1","GCSH","LIPT1","SDHAF2","LIPT2","GLRX5"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PHOSPHOLIPASE_ACTIVITY","pval":0.94775,"padj":0.99093,"ES":0.24173,"NES":0.3162,"nMoreExtreme":51515,"size":7,"leadingEdge":["ABL1","RGS2","ANXA1","BICD1","PLA2R1"]} {"pathway":"GO_REGULATION_OF_TRIGLYCERIDE_CATABOLIC_PROCESS","pval":0.95765,"padj":0.9934,"ES":0.23607,"NES":0.31566,"nMoreExtreme":51396,"size":6,"leadingEdge":["ABHD5","PIK3CG","GPLD1"]} {"pathway":"GO_HISTONE_H2A_ACETYLATION","pval":0.98087,"padj":0.99925,"ES":0.24565,"NES":0.31558,"nMoreExtreme":58756,"size":16,"leadingEdge":["MSL3","ING3","NAA40","BRD8","EPC1","MORF4L2","YEATS4","ACTL6A","MEAF6","RUVBL1","DMAP1","RUVBL2","EP400","MORF4L1","TRRAP"]} {"pathway":"GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_EXONUCLEOLYTIC","pval":0.99971,"padj":1,"ES":0.21908,"NES":0.31554,"nMoreExtreme":66632,"size":35,"leadingEdge":["EDC4","EXOSC7","EXOSC5","DIS3","LSM5","EXOSC3","DCPS","DDX6","HBS1L","CNOT6","EXOSC8","EXOSC9","LSM7","LSM4","EXOSC2","WDR61","NT5C3B","DIS3L2","DCP1B","CNOT8","LSM6","PATL1","POLR2G","LSM3","EXOSC1","DCP2","LSM1","EXOSC4","EDC3","TTC37","CNOT7","SKIV2L","LSM2","EXOSC6"]} {"pathway":"GO_LATE_ENDOSOME_TO_VACUOLE_TRANSPORT","pval":0.98087,"padj":0.99925,"ES":0.24556,"NES":0.31546,"nMoreExtreme":58756,"size":16,"leadingEdge":["CHMP2B","LEPROTL1","CHMP3","BECN1","CHMP2A","CHMP1A","VPS25","VPS36","TMEM50B","CHMP7","SNF8","VPS28"]} {"pathway":"GO_GOLGI_TO_VACUOLE_TRANSPORT","pval":0.97205,"padj":0.99732,"ES":0.24736,"NES":0.31479,"nMoreExtreme":57215,"size":14,"leadingEdge":["EHD3","AP3D1","VTI1B","GOSR2","CCDC91","RBSN","VPS54","VTI1A","AP1G1","GAK","ANKFY1","LAMP1","AP4M1","VPS52"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_SALT_STRESS","pval":0.94757,"padj":0.99093,"ES":0.24295,"NES":0.31358,"nMoreExtreme":52211,"size":8,"leadingEdge":["XRCC5","AKR1B1","CAPN3","TRPV4"]} {"pathway":"GO_PROTEIN_TRANSMEMBRANE_IMPORT_INTO_INTRACELLULAR_ORGANELLE","pval":0.99951,"padj":1,"ES":0.2199,"NES":0.31209,"nMoreExtreme":65730,"size":32,"leadingEdge":["TIMM21","LONP2","TIMM44","TIMM50","PEX12","GRPEL1","PEX7","DNAJC15","PEX16","PEX6","ROMO1","TIMM17B","PEX1","TOMM40","TIMM17A","PEX5","PEX14","HSPD1","PEX10","TOMM40L","PEX13","CHCHD4","GRPEL2","PEX2","TOMM20","TOMM7","TIMM23B","DNAJC19","DNLZ","PEX26","PAM16"]} {"pathway":"GO_TRANSLATIONAL_TERMINATION","pval":1,"padj":1,"ES":0.18748,"NES":0.30982,"nMoreExtreme":79040,"size":103,"leadingEdge":["UPF1","MRPS10","MRPL43","MRPS35","MRPS24","MRPS34","JMJD4","MRPL22","MRPL28","OGFOD1","MRPS33","MRPS18A","MRPS31","GSPT1","MRPL4","MRPL32","MRPL27","MRPL51","MTRF1L","MRPL18","MRPL2","MRPS30","MRPS27","MRPL3","MRPL19","MRPL37","MRPS15","GLE1","MRPS14","MTRF1","ETF1","MRPS2","MRPS7","MRPS26","MRPS12","MRPL34","C12orf65","MRPS25","PTCD3","MRPL35","EIF5A","ERAL1","DAP3","MRPS36","MRPL44","MRPS9","MRPL47","MRPL50","MRPL15","MRPL24","MRPL9","MRPS5","MRPS28","MRRF","MRPL49","MRPL39","OXA1L","N6AMT1","MRPL17","MRPL10","MRPL55","MRPS18C","EIF5A2","APEH","ABCE1","GFM2","MRPL16","MRPL58","MRPL1","MRPL36","MRPL13","CHCHD1","MRPL52","TRMT112","MRPL57","MRPL11","MRPS22","MRPL48","AURKAIP1","GADD45GIP1","MRPL14","MRPS23","MRPS11","MRPL41","MRPS16","MRPL54","MRPL30","MRPL40"]} {"pathway":"GO_NUCLEOTIDE_SUGAR_METABOLIC_PROCESS","pval":0.98537,"padj":0.99994,"ES":0.23756,"NES":0.30722,"nMoreExtreme":59545,"size":17,"leadingEdge":["FUT8","UGGT2","TSTA3","GMDS","SLC35A3","GFPT2","UGGT1","GUK1","CSGALNACT1","GNE","EXTL2","B4GALNT2","UGP2","DPAGT1","GFPT1","GALT","PARG"]} {"pathway":"GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM","pval":1,"padj":1,"ES":0.18296,"NES":0.30444,"nMoreExtreme":79922,"size":111,"leadingEdge":["SEC62","RPS20","SEC63","HSPA5","SEC61A1","RPL18","TRAM2","SEC61A2","TRAM1","RPL31","RPS5","RAB10","RPLP0","RPL3","PMM1","SRP54","CHMP4B","SGTA","RPS16","RPS19","RPL18A","SEC61B","RPL28","RPL19","RPL34","RPS13","RPS12","RPL24","SSR3","SPCS1","RPS15","RAB3GAP1","RPL22","RPS25","SPCS2","RAB3GAP2","RPL21","RPL5","RPS10","RPL23","SPCS3","RPL36","RPL27","SEC61G","RPS15A","RPL35","RPS6","RPLP1","RPS24","SRP14","PMM2","RPS2","RPS11","RPL13A","RPL11","RPS8","SRP9","RPS27A","RPL32","RPS3A","RPL37","RPL10","RPL7","RPL7A","RPS3","SRP19","RPL30","ZFAND2B","RPL8","RPL26","RPL29","RPL9","RPS14","RPL27A","RPL13","SRP68","RPSA","RPS9","RPS21","RPS7","RPL38","RPL4","TRAM1L1","RPL15","SRP72","RPLP2","RPS27","RPS17","RPL35A","SRPRA","RPS23","RPL14","RPS26","RPL37A","SGTB","RPL12","RPS4X","RPL23A","RPL10A","RPL39"]} {"pathway":"GO_RIBOSOMAL_LARGE_SUBUNIT_ASSEMBLY","pval":0.99852,"padj":1,"ES":0.21895,"NES":0.30243,"nMoreExtreme":64204,"size":27,"leadingEdge":["MRTO4","WDR18","NLE1","RPLP0","RPL3","NOP53","NOP2","MDN1","BRIX1","RPL24","FASTKD2","RPL5","PPAN","TRAF7","DHX30","RSL24D1","RPL11","RPL10"]} {"pathway":"GO_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE","pval":1,"padj":1,"ES":0.18194,"NES":0.29984,"nMoreExtreme":78675,"size":100,"leadingEdge":["SEC62","RPS20","SEC63","SEC61A1","RPL18","TRAM2","SEC61A2","TRAM1","RPL31","RPS5","RPLP0","RPL3","SRP54","RPS16","RPS19","RPL18A","SEC61B","RPL28","RPL19","RPL34","RPS13","RPS12","RPL24","SSR3","RPS15","RPL22","RPS25","RPL21","RPL5","RPS10","SSR1","RPL23","RPL36","RPL27","RPS15A","RPL35","RPS6","RPLP1","RPS24","SRP14","RPS2","RPS11","RPL13A","RPL11","RPS8","SRP9","RPS27A","RPL32","RPS3A","RPL37","RPL10","RPL7","RPL7A","RPS3","SRP19","RPL30","ZFAND2B","RPL8","RPL26","RPL29","SSR2","RPL9","RPS14","RPL27A","RPL13","SRP68","RPSA","ARL6IP1","RPS9","RPS21","RPS7","RPL38","RPL4","TRAM1L1","RPL15","SRP72","RPLP2","RPS27","RPS17","RPL35A","SRPRA","RPS23","RPL14","RPS26","RPL37A","RPL12","RPS4X","RPL23A","RPL10A","RPL39"]} {"pathway":"GO_RRNA_CONTAINING_RIBONUCLEOPROTEIN_COMPLEX_EXPORT_FROM_NUCLEUS","pval":0.98289,"padj":0.99955,"ES":0.23222,"NES":0.29833,"nMoreExtreme":58877,"size":16,"leadingEdge":["RIOK2","XPO1","BCCIP","NUP88","RPS15","RAN","LTV1","ZNF593","ABCE1","TSC1","RPSA","NMD3","RRS1","NPM1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_TRANSLATION","pval":0.98703,"padj":0.99994,"ES":0.22431,"NES":0.29008,"nMoreExtreme":59645,"size":17,"leadingEdge":["UQCC1","CDK5RAP1","C1QBP","MRPS27","NSUN4","FASTKD2","FASTKD3","UQCC2","RMND1","RPUSD3","RPUSD4","TRUB2","TRMT10C","NGRN","COA3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ACTIN_NUCLEATION","pval":0.96608,"padj":0.99537,"ES":0.22068,"NES":0.28866,"nMoreExtreme":52511,"size":7,"leadingEdge":["PICK1","CORO1A","GMFG","HIP1R"]} {"pathway":"GO_MODULATION_OF_MICROTUBULE_CYTOSKELETON_INVOLVED_IN_CEREBRAL_CORTEX_RADIAL_GLIA_GUIDED_MIGRATION","pval":0.98651,"padj":0.99994,"ES":0.20829,"NES":0.28652,"nMoreExtreme":52199,"size":5,"leadingEdge":["SYNE2","SUN2","SUN1","SRGAP2C"]} {"pathway":"GO_RETINA_LAYER_FORMATION","pval":0.9772,"padj":0.99889,"ES":0.225,"NES":0.28633,"nMoreExtreme":57518,"size":14,"leadingEdge":["PROM1","HIPK2","SDK2","ARL6","ATP8A2","AHI1","TFAP2A","SDK1","RDH13","HIPK1","PTPRM","FJX1","TOPORS"]} {"pathway":"GO_MICROTUBULE_SEVERING","pval":0.96382,"padj":0.995,"ES":0.22552,"NES":0.28631,"nMoreExtreme":54403,"size":10,"leadingEdge":["SPAST","KATNAL1","LZTS2","FIGNL1","KATNB1","KATNAL2","TTLL11","FIGN","KATNA1"]} {"pathway":"GO_MITOCHONDRIAL_TRANSLATIONAL_TERMINATION","pval":1,"padj":1,"ES":0.1756,"NES":0.28576,"nMoreExtreme":77038,"size":89,"leadingEdge":["MRPS10","MRPL43","MRPS35","MRPS24","MRPS34","MRPL22","MRPL28","MRPS33","MRPS18A","MRPS31","MRPL4","MRPL32","MRPL27","MRPL51","MTRF1L","MRPL18","MRPL2","MRPS30","MRPS27","MRPL3","MRPL19","MRPL37","MRPS15","MRPS14","MTRF1","MRPS2","MRPS7","MRPS26","MRPS12","MRPL34","MRPS25","PTCD3","MRPL35","ERAL1","DAP3","MRPS36","MRPL44","MRPS9","MRPL47","MRPL50","MRPL15","MRPL24","MRPL9","MRPS5","MRPS28","MRRF","MRPL49","MRPL39","OXA1L","MRPL17","MRPL10","MRPL55","MRPS18C","GFM2","MRPL16","MRPL58","MRPL1","MRPL36","MRPL13","CHCHD1","MRPL52","MRPL57","MRPL11","MRPS22","MRPL48","AURKAIP1","GADD45GIP1","MRPL14","MRPS23","MRPS11","MRPL41","MRPS16","MRPL54","MRPL30","MRPL40"]} {"pathway":"GO_TRNA_WOBBLE_BASE_MODIFICATION","pval":0.99405,"padj":1,"ES":0.21299,"NES":0.28315,"nMoreExtreme":61866,"size":21,"leadingEdge":["ELP1","TRMU","ALKBH1","ELP4","MOCS3","GTPBP3","ELP3","ELP2","MTO1","ALKBH8","CTU1","DPH3","ELP6","URM1","ELP5","CTU2","NSUN3","ADAT2","KTI12","ADAT3"]} {"pathway":"GO_UTP_BIOSYNTHETIC_PROCESS","pval":0.97102,"padj":0.99701,"ES":0.21429,"NES":0.28031,"nMoreExtreme":52780,"size":7,"leadingEdge":["CAD","NME3","NME4"]} {"pathway":"GO_MATURATION_OF_LSU_RRNA","pval":0.99288,"padj":1,"ES":0.21184,"NES":0.27967,"nMoreExtreme":61374,"size":20,"leadingEdge":["LAS1L","PES1","SNU13","GTPBP4","FTSJ3","ZNHIT6","RPL35","WDR12","URB1","NHP2","RPL7L1","RPL7","RPL7A","NOL9","MRPL1","RSL1D1"]} {"pathway":"GO_MRNA_3_SPLICE_SITE_RECOGNITION","pval":0.98181,"padj":0.99935,"ES":0.20685,"NES":0.2766,"nMoreExtreme":52693,"size":6,"leadingEdge":["SF3A1","SF3A2","SLU7","SF1","SF3A3","ISY1"]} {"pathway":"GO_ACTIN_MODIFICATION","pval":0.99051,"padj":1,"ES":0.20106,"NES":0.27657,"nMoreExtreme":52411,"size":5,"leadingEdge":["TRIOBP","TRIM32","TWF1","SETD3","NAA80"]} {"pathway":"GO_CEREBELLAR_PURKINJE_CELL_LAYER_FORMATION","pval":0.97323,"padj":0.99756,"ES":0.21142,"NES":0.27656,"nMoreExtreme":52900,"size":7,"leadingEdge":["RORA","WHRN","HERC1"]} {"pathway":"GO_2FE_2S_CLUSTER_ASSEMBLY","pval":0.991,"padj":1,"ES":0.19982,"NES":0.27487,"nMoreExtreme":52437,"size":5,"leadingEdge":["HSCB","GLRX3","BOLA2B","BOLA2","NFS1"]} {"pathway":"GO_REGULATION_OF_T_CIRCLE_FORMATION","pval":0.97443,"padj":0.9981,"ES":0.20989,"NES":0.27455,"nMoreExtreme":52965,"size":7,"leadingEdge":["ERCC1","XRCC5","SLX1A","TERF2"]} {"pathway":"GO_COPI_COATED_VESICLE_BUDDING","pval":0.98323,"padj":0.99955,"ES":0.20388,"NES":0.27262,"nMoreExtreme":52769,"size":6,"leadingEdge":["TMED2","GBF1","ARFGAP2","TMED10","TMED9","ARFGAP3"]} {"pathway":"GO_PEPTIDYL_PROLINE_HYDROXYLATION_TO_4_HYDROXY_L_PROLINE","pval":0.97561,"padj":0.99825,"ES":0.20695,"NES":0.26711,"nMoreExtreme":53756,"size":8,"leadingEdge":["P4HA2","P4HA1","EGLN3","EGLN1","P4HA3","P4HTM","P4HB"]} {"pathway":"GO_RIBOSOMAL_SMALL_SUBUNIT_ASSEMBLY","pval":0.98962,"padj":1,"ES":0.20479,"NES":0.26484,"nMoreExtreme":59802,"size":17,"leadingEdge":["RPS5","RPS19","RPS15","RPS10","MRPS7","ERAL1","ABT1","RPS14","RPSA","RPL38","RPS27","MRPS11","RRP7BP","RPS27L","RRP7A","RPS28","PWP2"]} {"pathway":"GO_HISTONE_H3_K4_TRIMETHYLATION","pval":0.98116,"padj":0.99935,"ES":0.20763,"NES":0.2631,"nMoreExtreme":57143,"size":13,"leadingEdge":["KMT2E","ARID4A","KMT2A","RTF1","WDR61","OGT","WDR82","TET2","BEND3","TET3","ZNF335","CTR9"]} {"pathway":"GO_PYRIMIDINE_RIBONUCLEOTIDE_BIOSYNTHETIC_PROCESS","pval":0.99135,"padj":1,"ES":0.20081,"NES":0.26153,"nMoreExtreme":60315,"size":18,"leadingEdge":["CTPS2","CAD","UPRT","DHODH","NME3","NME4","UMPS","UCK1","NME7","UCK2","AK5","CMPK1","CTPS1","NME6","UPP1","UCKL1","NME1","NME2"]} {"pathway":"GO_RIBOSOME_ASSEMBLY","pval":1,"padj":1,"ES":0.1687,"NES":0.26074,"nMoreExtreme":71745,"size":57,"leadingEdge":["MRTO4","WDR18","NLE1","MRPL22","RPS5","RPLP0","RPL3","RPS19","NOP53","C1QBP","NOP2","MDN1","BRIX1","RPL24","RPS15","NSUN4","FASTKD2","MTERF4","MRPS2","RPL5","RPS10","MRPS7","SBDS","PPAN","TRAF7","DHX30","ERAL1","NIP7","RSL24D1","EFL1","RPL11","EIF2A","ABT1","RPL10","MTERF3","RPS14","RPSA","RPL38","MRPL11","RPS27","RRS1","NPM1","MRPS11","DDX28","RRP7BP","RPS27L","RRP7A","RPF2","RPL12","RPL23A","DDX3X","RPS28","PWP2","EIF6","MRPL20"]} {"pathway":"GO_4_HYDROXYPROLINE_METABOLIC_PROCESS","pval":0.97853,"padj":0.99901,"ES":0.20209,"NES":0.25592,"nMoreExtreme":55873,"size":11,"leadingEdge":["P4HA2","ERO1B","P4HA1","PRDX4","EGLN3","EGLN1","P4HA3","P4HTM","P4HB","ERO1A"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_NUCLEOLUS","pval":0.97905,"padj":0.99901,"ES":0.20103,"NES":0.25456,"nMoreExtreme":55903,"size":11,"leadingEdge":["POLR1A","NOP53","RAN","NVL","WRN","NMD3","RRS1","MCRS1","RPF2","NOL8"]} {"pathway":"GO_PROTEIN_IMPORT_INTO_MITOCHONDRIAL_MATRIX","pval":0.99213,"padj":1,"ES":0.1954,"NES":0.25448,"nMoreExtreme":60362,"size":18,"leadingEdge":["TIMM21","TIMM44","TIMM50","GRPEL1","DNAJC15","ROMO1","TIMM17B","TOMM40","TIMM17A","TOMM40L","GRPEL2","TOMM20","TOMM7","TIMM23B","DNAJC19","DNLZ","PAM16"]} {"pathway":"GO_PYRIMIDINE_RIBONUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS","pval":0.9806,"padj":0.99925,"ES":0.20074,"NES":0.2542,"nMoreExtreme":56563,"size":12,"leadingEdge":["CTPS2","CAD","NME3","NME4","UCK1","NME7","UCK2","CTPS1","NME6","UCKL1","NME1","NME2"]} {"pathway":"GO_REGULATION_OF_TRANSLATIONAL_FIDELITY","pval":0.9875,"padj":1,"ES":0.1887,"NES":0.23912,"nMoreExtreme":57512,"size":13,"leadingEdge":["LARS2","IARS2","RPS5","CDK5RAP1","DTD1","DTD2","VARS2","TARS2"]} {"pathway":"GO_SMALL_NUCLEOLAR_RIBONUCLEOPROTEIN_COMPLEX_ASSEMBLY","pval":0.99065,"padj":1,"ES":0.17489,"NES":0.22146,"nMoreExtreme":56565,"size":11,"leadingEdge":["NUFIP1","SNU13","PIH1D1","ZNHIT6","SHQ1","NAF1","PIH1D2"]} {"pathway":"GO_BOX_C_D_SNORNP_ASSEMBLY","pval":0.99136,"padj":1,"ES":-0.16576,"NES":-0.22203,"nMoreExtreme":43736,"size":9,"leadingEdge":["TAF9","ZNHIT3","RUVBL2","RUVBL1","PIH1D2","ZNHIT6","PIH1D1","SNU13","NUFIP1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_III","pval":0.96866,"padj":0.99598,"ES":-0.19937,"NES":-0.26433,"nMoreExtreme":42190,"size":10,"leadingEdge":["CEBPA","MTOR","BRF1","AR","ICE1","ZC3H8","RPTOR","ICE2","ELL","CHD8"]} {"pathway":"GO_GUANOSINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS","pval":0.95949,"padj":0.9934,"ES":-0.21287,"NES":-0.28021,"nMoreExtreme":41163,"size":11,"leadingEdge":["NME2","NME1","IMPDH2","NME6","HPRT1","GMPS","GUK1","NME7","IMPDH1","NME4","NME3"]} {"pathway":"GO_FUCOSE_METABOLIC_PROCESS","pval":0.97086,"padj":0.99701,"ES":-0.2054,"NES":-0.28401,"nMoreExtreme":44315,"size":7,"leadingEdge":["FPGT","B3GLCT","POFUT2","FUCA1"]} {"pathway":"GO_GTP_BIOSYNTHETIC_PROCESS","pval":0.95922,"padj":0.9934,"ES":-0.21283,"NES":-0.28917,"nMoreExtreme":43070,"size":8,"leadingEdge":["NME2","NME1","IMPDH2","NME6","NME7","IMPDH1","NME4","NME3"]} {"pathway":"GO_REGULATION_OF_TRANSLATION_AT_SYNAPSE_MODULATING_SYNAPTIC_TRANSMISSION","pval":0.97556,"padj":0.99825,"ES":-0.21779,"NES":-0.31739,"nMoreExtreme":45937,"size":5,"leadingEdge":["CYFIP1","MTOR","EIF4E","EIF4A3"]} {"pathway":"GO_PROTEIN_MATURATION_BY_IRON_SULFUR_CLUSTER_TRANSFER","pval":0.95981,"padj":0.9934,"ES":-0.24242,"NES":-0.32034,"nMoreExtreme":38947,"size":15,"leadingEdge":["CISD3","YAE1","BOLA2","MAGEF1","BOLA2B","NFU1","CIAO2A","CIAO2B","ISCA2","MMS19","LTO1","CIAO1","ISCA1"]} {"pathway":"GO_PEPTIDYL_HISTIDINE_MODIFICATION","pval":0.92642,"padj":0.987,"ES":-0.24809,"NES":-0.32892,"nMoreExtreme":40350,"size":10,"leadingEdge":["NME2","SETD3","DNAJC24","HIF1AN","DPH3","DPH7","DPH6","DPH2","DPH5","DPH1"]} {"pathway":"GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEOLUS","pval":0.96362,"padj":0.995,"ES":-0.22998,"NES":-0.33515,"nMoreExtreme":45375,"size":5,"leadingEdge":["PINX1","MCRS1","NMD3","NVL"]} {"pathway":"GO_REGULATION_OF_DNA_CATABOLIC_PROCESS","pval":0.91914,"padj":0.987,"ES":-0.25713,"NES":-0.3409,"nMoreExtreme":40033,"size":10,"leadingEdge":["PAM16","HSF1","ST20","NMNAT1","ENDOG","DFFA","AIFM1","ATM"]} {"pathway":"GO_CYTOPLASMIC_MRNA_PROCESSING_BODY_ASSEMBLY","pval":0.97973,"padj":0.99901,"ES":-0.25402,"NES":-0.34676,"nMoreExtreme":37412,"size":20,"leadingEdge":["LSM14A","PATL2","ATXN2","NBDY","CNOT7","DYNC1H1","EDC3","LSM3","ATXN2L","PATL1","PAN3","NOCT","LIMD1","CNOT6L","RC3H1","PAN2","LSM4","CNOT1","CNOT6","DDX6"]} {"pathway":"GO_AMP_BIOSYNTHETIC_PROCESS","pval":0.97606,"padj":0.9985,"ES":-0.23337,"NES":-0.35111,"nMoreExtreme":46807,"size":4,"leadingEdge":["ADSL","APRT","ADK"]} {"pathway":"GO_REGULATION_OF_APOPTOTIC_DNA_FRAGMENTATION","pval":0.90657,"padj":0.98422,"ES":-0.26376,"NES":-0.35331,"nMoreExtreme":39995,"size":9,"leadingEdge":["PAM16","HSF1","ST20","NMNAT1","ENDOG","DFFA","AIFM1"]} {"pathway":"GO_REGULATION_OF_PROTEIN_MONOUBIQUITINATION","pval":0.922,"padj":0.987,"ES":-0.25371,"NES":-0.35927,"nMoreExtreme":42717,"size":6,"leadingEdge":["PDCD6","FANCM","UBB","PEF1","WDR48","BIRC2"]} {"pathway":"GO_REGULATION_OF_CYTOPLASMIC_MRNA_PROCESSING_BODY_ASSEMBLY","pval":0.90117,"padj":0.98417,"ES":-0.2692,"NES":-0.3606,"nMoreExtreme":39757,"size":9,"leadingEdge":["PATL2","ATXN2","NBDY","ATXN2L","PAN3","CNOT6L","PAN2","CNOT1","CNOT6"]} {"pathway":"GO_PHENOL_CONTAINING_COMPOUND_CATABOLIC_PROCESS","pval":0.92688,"padj":0.987,"ES":-0.2589,"NES":-0.3773,"nMoreExtreme":43645,"size":5,"leadingEdge":["SULT1A3","MAOA","LRTOMT"]} {"pathway":"GO_PRENYLATION","pval":0.88266,"padj":0.98086,"ES":-0.27939,"NES":-0.3796,"nMoreExtreme":39632,"size":8,"leadingEdge":["FNTB","CHML","PTAR1","CHM","FNTA","PGGT1B"]} {"pathway":"GO_COLLAGEN_ACTIVATED_SIGNALING_PATHWAY","pval":0.91706,"padj":0.987,"ES":-0.29112,"NES":-0.38282,"nMoreExtreme":38808,"size":12,"leadingEdge":["DDR1","COL4A6","COL4A5","COL4A1","OSCAR","SYK","ITGA2","DDR2","UBASH3B","ITGA11","COL4A2"]} {"pathway":"GO_MITOCHONDRIAL_RIBOSOME_ASSEMBLY","pval":0.86075,"padj":0.97645,"ES":-0.29474,"NES":-0.40754,"nMoreExtreme":39289,"size":7,"leadingEdge":["MPV17L2","DDX28","MTERF3","DHX30","MRPS2","MTERF4","FASTKD2"]} {"pathway":"GO_UDP_N_ACETYLGLUCOSAMINE_METABOLIC_PROCESS","pval":0.86614,"padj":0.97662,"ES":-0.29298,"NES":-0.41487,"nMoreExtreme":40129,"size":6,"leadingEdge":["GFPT1","DPAGT1","B4GALNT2","GNE","GFPT2","SLC35A3"]} {"pathway":"GO_REGULATION_OF_PHOSPHOLIPASE_A2_ACTIVITY","pval":0.87846,"padj":0.97973,"ES":-0.31743,"NES":-0.42085,"nMoreExtreme":38261,"size":10,"leadingEdge":["ANXA8","ANXA8L1","ANG","PLA2R1","EGFR","AGTR1","PLAA","ANXA1","PPT1","LRP1"]} {"pathway":"GO_CHYLOMICRON_ASSEMBLY","pval":0.87224,"padj":0.97743,"ES":-0.29425,"NES":-0.42883,"nMoreExtreme":41072,"size":5,"leadingEdge":["APOC2","P4HB","APOE","PLAGL2","APOA1"]} {"pathway":"GO_TUBULIN_COMPLEX_ASSEMBLY","pval":0.84896,"padj":0.9761,"ES":-0.30466,"NES":-0.43142,"nMoreExtreme":39333,"size":6,"leadingEdge":["ARL2","TBCA","VBP1","TBCD","TBCC","TCP1"]} {"pathway":"GO_RECEPTOR_LOCALIZATION_TO_NON_MOTILE_CILIUM","pval":0.89217,"padj":0.98251,"ES":-0.29865,"NES":-0.44932,"nMoreExtreme":42784,"size":4,"leadingEdge":["BBIP1","ARL13B","TUB"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_CATABOLIC_PROCESS","pval":0.93601,"padj":0.98783,"ES":-0.29224,"NES":-0.45101,"nMoreExtreme":45752,"size":3,"leadingEdge":["APOC2","PNPLA2"]} {"pathway":"GO_REGULATION_OF_VERY_LOW_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING","pval":0.98444,"padj":0.99994,"ES":-0.2942,"NES":-0.45285,"nMoreExtreme":48980,"size":2,"leadingEdge":["APOC2","APOA1"]} {"pathway":"GO_DENDRITE_SELF_AVOIDANCE","pval":0.86675,"padj":0.97662,"ES":-0.34171,"NES":-0.45304,"nMoreExtreme":37751,"size":10,"leadingEdge":["CNTN2","BSG","EMB","NEXN","NPTN","ROBO3","CNTN4","CNTN6","VSTM2L","PALLD"]} {"pathway":"GO_PENILE_ERECTION","pval":0.84427,"padj":0.97458,"ES":-0.31111,"NES":-0.45339,"nMoreExtreme":39755,"size":5,"leadingEdge":["ADA","OXTR","P2RY1","EDNRB","ACVR2A"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_MONOUBIQUITINATION","pval":0.84402,"padj":0.97458,"ES":-0.31126,"NES":-0.45362,"nMoreExtreme":39743,"size":5,"leadingEdge":["PDCD6","FANCM","UBB","PEF1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PEROXISOME_PROLIFERATOR_ACTIVATED_RECEPTOR_SIGNALING_PATHWAY","pval":0.82645,"padj":0.97439,"ES":-0.32045,"NES":-0.45378,"nMoreExtreme":38290,"size":6,"leadingEdge":["STARD10","FABP5","CITED2","ASXL2","GPS2","PTGIS"]} {"pathway":"GO_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION_OF_STAT_PROTEIN","pval":0.82787,"padj":0.97439,"ES":-0.33841,"NES":-0.45979,"nMoreExtreme":37172,"size":8,"leadingEdge":["GGNBP2","ERCC6","IFNA1","IFNW1","IFNB1","RET","PWP1","LIF"]} {"pathway":"GO_TRICUSPID_VALVE_DEVELOPMENT","pval":0.82924,"padj":0.97439,"ES":-0.32042,"NES":-0.46696,"nMoreExtreme":39047,"size":5,"leadingEdge":["BMPR2","ZFPM1","TBX20","TGFBR2"]} {"pathway":"GO_GLOSSOPHARYNGEAL_NERVE_DEVELOPMENT","pval":0.92189,"padj":0.987,"ES":-0.30338,"NES":-0.4682,"nMoreExtreme":45062,"size":3,"leadingEdge":["PLXNA4","NAV2","HOXB3"]} {"pathway":"GO_MICROTUBULE_NUCLEATION_BY_INTERPHASE_MICROTUBULE_ORGANIZING_CENTER","pval":0.81259,"padj":0.97053,"ES":-0.33079,"NES":-0.46841,"nMoreExtreme":37648,"size":6,"leadingEdge":["TUBGCP5","MZT1","TUBGCP4","TUBGCP2","TUBGCP6","TUBGCP3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_METHYLATION_DEPENDENT_CHROMATIN_SILENCING","pval":0.84245,"padj":0.97458,"ES":-0.35006,"NES":-0.46891,"nMoreExtreme":37166,"size":9,"leadingEdge":["MPHOSPH8","RESF1","ATF7IP","TASOR","SETDB1","PPHLN1","MORC2","DNMT1","TRIM28"]} {"pathway":"GO_TRANSEPITHELIAL_CHLORIDE_TRANSPORT","pval":0.86584,"padj":0.97662,"ES":-0.31331,"NES":-0.47137,"nMoreExtreme":41521,"size":4,"leadingEdge":["SLC26A6","P2RY6","BEST1"]} {"pathway":"GO_SOMATIC_MOTOR_NEURON_DIFFERENTIATION","pval":0.97128,"padj":0.99706,"ES":-0.30903,"NES":-0.47568,"nMoreExtreme":48325,"size":2,"leadingEdge":["TCTN1","LHX4"]} {"pathway":"GO_DE_NOVO_IMP_BIOSYNTHETIC_PROCESS","pval":0.80303,"padj":0.96646,"ES":-0.33747,"NES":-0.47788,"nMoreExtreme":37205,"size":6,"leadingEdge":["ADSL","PFAS","GART","ATIC","PPAT","PAICS"]} {"pathway":"GO_OBSERVATIONAL_LEARNING","pval":0.80117,"padj":0.96646,"ES":-0.33893,"NES":-0.47995,"nMoreExtreme":37119,"size":6,"leadingEdge":["SHANK3","HTT","NF1","CNTNAP2","STRA6","FOXP2"]} {"pathway":"GO_DEADENYLATION_DEPENDENT_DECAPPING_OF_NUCLEAR_TRANSCRIBED_MRNA","pval":0.86046,"padj":0.97645,"ES":-0.36258,"NES":-0.48071,"nMoreExtreme":37477,"size":10,"leadingEdge":["DCP1A","PATL2","CNOT7","LSM1","DCP2","PATL1","PAN3","DCP1B","NOCT"]} {"pathway":"GO_PEPTIDYL_ARGININE_METHYLATION_TO_ASYMMETRICAL_DIMETHYL_ARGININE","pval":0.81072,"padj":0.96976,"ES":-0.33172,"NES":-0.48343,"nMoreExtreme":38175,"size":5,"leadingEdge":["PRMT6","PRMT3","PRMT2","CARM1","PRMT1"]} {"pathway":"GO_DISACCHARIDE_METABOLIC_PROCESS","pval":0.80558,"padj":0.96708,"ES":-0.33493,"NES":-0.4881,"nMoreExtreme":37933,"size":5,"leadingEdge":["MGAM","GANC","GAA","BRAF","IDUA"]} {"pathway":"GO_BEHAVIORAL_RESPONSE_TO_NICOTINE","pval":0.84363,"padj":0.97458,"ES":-0.32533,"NES":-0.48946,"nMoreExtreme":40456,"size":4,"leadingEdge":["PPARA","CHRNB1","CHRNA5"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_FEMALE_GONAD_DEVELOPMENT","pval":0.83981,"padj":0.97458,"ES":-0.32729,"NES":-0.49242,"nMoreExtreme":40273,"size":4,"leadingEdge":["HYAL3","WT1","ZFPM2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_VASOCONSTRICTION","pval":0.79938,"padj":0.96646,"ES":-0.33863,"NES":-0.4935,"nMoreExtreme":37641,"size":5,"leadingEdge":["BMPR2","ARHGAP42","ADM","DOCK5","DOCK4"]} {"pathway":"GO_RESPONSE_TO_ALUMINUM_ION","pval":0.83084,"padj":0.97439,"ES":-0.3321,"NES":-0.49964,"nMoreExtreme":39843,"size":4,"leadingEdge":["LONP1","QDPR","ALAD","BECN1"]} {"pathway":"GO_DIOL_METABOLIC_PROCESS","pval":0.82959,"padj":0.97439,"ES":-0.33311,"NES":-0.50116,"nMoreExtreme":39783,"size":4,"leadingEdge":["ASAH2","SPHK1","SGPP2","SGPP1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_8_SECRETION","pval":0.7853,"padj":0.96311,"ES":-0.37041,"NES":-0.51218,"nMoreExtreme":35845,"size":7,"leadingEdge":["TMSB4X","ANXA4","SSC5D","TLR6","MAPKBP1","ANXA1","PTPN22"]} {"pathway":"GO_ISOPRENOID_CATABOLIC_PROCESS","pval":0.93794,"padj":0.98783,"ES":-0.33734,"NES":-0.51925,"nMoreExtreme":46666,"size":2,"leadingEdge":["BCO2","SRD5A3"]} {"pathway":"GO_PYRIMIDINE_RIBONUCLEOTIDE_SALVAGE","pval":0.7984,"padj":0.96646,"ES":-0.34974,"NES":-0.52618,"nMoreExtreme":38287,"size":4,"leadingEdge":["UCKL1","UPP1","UCK2","UCK1"]} {"pathway":"GO_REGULATION_OF_GLYCOGEN_CATABOLIC_PROCESS","pval":0.76438,"padj":0.96082,"ES":-0.36329,"NES":-0.52944,"nMoreExtreme":35993,"size":5,"leadingEdge":["PPP1CB","PPP1R3B","PPP1CA","PHKG2","PPP1R3D"]} {"pathway":"GO_AUTOPHAGY_OF_NUCLEUS","pval":0.77523,"padj":0.96098,"ES":-0.36291,"NES":-0.546,"nMoreExtreme":37176,"size":4,"leadingEdge":["ATG9A","ATG7","ATG13"]} {"pathway":"GO_PROLACTIN_SECRETION","pval":0.74812,"padj":0.9603,"ES":-0.37543,"NES":-0.54713,"nMoreExtreme":35227,"size":5,"leadingEdge":["ABAT","ANXA5","UBE2Q1","EGFR","ANXA1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC","pval":0.74576,"padj":0.96025,"ES":-0.37711,"NES":-0.54958,"nMoreExtreme":35116,"size":5,"leadingEdge":["PLA2G6","GRIK2","ADORA1","ATAD1","HTR1B"]} {"pathway":"GO_METANEPHRIC_PART_OF_URETERIC_BUD_DEVELOPMENT","pval":0.76128,"padj":0.96082,"ES":-0.37049,"NES":-0.55741,"nMoreExtreme":36507,"size":4,"leadingEdge":["LHX1","WT1","BASP1"]} {"pathway":"GO_PARALLEL_ACTIN_FILAMENT_BUNDLE_ASSEMBLY","pval":0.76093,"padj":0.96082,"ES":-0.37069,"NES":-0.5577,"nMoreExtreme":36490,"size":4,"leadingEdge":["SPIRE2","AIF1","FMN2","SPIRE1"]} {"pathway":"GO_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE_SIGNAL_SEQUENCE_RECOGNITION","pval":0.73571,"padj":0.95787,"ES":-0.38428,"NES":-0.56003,"nMoreExtreme":34643,"size":5,"leadingEdge":["RN7SL1","RN7SL2","BHLHE40-AS1"]} {"pathway":"GO_POLYSACCHARIDE_DIGESTION","pval":0.8932,"padj":0.98267,"ES":-0.36452,"NES":-0.56109,"nMoreExtreme":44440,"size":2,"leadingEdge":["MGAM","CHIT1"]} {"pathway":"GO_LUTEINIZING_HORMONE_SECRETION","pval":0.75144,"padj":0.9603,"ES":-0.37608,"NES":-0.56582,"nMoreExtreme":36035,"size":4,"leadingEdge":["FOXD1","TMF1","SMAD4","TBX3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION_GABAERGIC","pval":0.74971,"padj":0.9603,"ES":-0.37709,"NES":-0.56734,"nMoreExtreme":35952,"size":4,"leadingEdge":["CNR2","ADORA1","STXBP1","HTR1B"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_MORPHINE","pval":0.80984,"padj":0.96941,"ES":-0.36998,"NES":-0.57098,"nMoreExtreme":39585,"size":3,"leadingEdge":["AIF1","ATG7"]} {"pathway":"GO_REGULATION_OF_PENILE_ERECTION","pval":0.73684,"padj":0.95787,"ES":-0.38423,"NES":-0.57807,"nMoreExtreme":35335,"size":4,"leadingEdge":["ADA","OXTR","P2RY1","EDNRB"]} {"pathway":"GO_POSITIVE_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS","pval":0.71947,"padj":0.95459,"ES":-0.39767,"NES":-0.57955,"nMoreExtreme":33878,"size":5,"leadingEdge":["RAB1B","CTNNB1","PXYLP1","TCF7L2","RAB1A"]} {"pathway":"GO_NEURON_FATE_SPECIFICATION","pval":0.93603,"padj":0.98783,"ES":-0.43955,"NES":-0.58083,"nMoreExtreme":37982,"size":15,"leadingEdge":["DLL1"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_MEMBRANE_RAFT","pval":0.78453,"padj":0.96311,"ES":-0.43195,"NES":-0.58688,"nMoreExtreme":35226,"size":8,"leadingEdge":["CD24"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PHOSPHOLIPASE_A2_ACTIVITY","pval":0.72656,"padj":0.95562,"ES":-0.39063,"NES":-0.58771,"nMoreExtreme":34842,"size":4,"leadingEdge":["ANG","EGFR","AGTR1","PLAA"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PENILE_ERECTION","pval":0.78335,"padj":0.96311,"ES":-0.3842,"NES":-0.59294,"nMoreExtreme":38290,"size":3,"leadingEdge":["OXTR","P2RY1","EDNRB"]} {"pathway":"GO_REGULATION_OF_HISTONE_H3_K36_METHYLATION","pval":0.72315,"padj":0.95562,"ES":-0.41961,"NES":-0.59419,"nMoreExtreme":33504,"size":6,"leadingEdge":["BCOR","NSD1","IWS1","PAXIP1","NSD3","BRD4"]} {"pathway":"GO_RESPONSE_TO_VITAMIN_A","pval":0.90127,"padj":0.98417,"ES":-0.45315,"NES":-0.59584,"nMoreExtreme":37637,"size":13,"leadingEdge":["TYMS","CAT"]} {"pathway":"GO_REPLACEMENT_OSSIFICATION","pval":0.98544,"padj":0.99994,"ES":-0.42725,"NES":-0.598,"nMoreExtreme":36543,"size":23,"leadingEdge":["RUNX2","BMP6","COL13A1","BMP4","FGFR3"]} {"pathway":"GO_REGULATION_OF_PODOSOME_ASSEMBLY","pval":0.91301,"padj":0.98622,"ES":-0.45728,"NES":-0.60217,"nMoreExtreme":37561,"size":14,"leadingEdge":["FSCN1","KIF9"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TOOTH_MINERALIZATION","pval":0.83553,"padj":0.97443,"ES":-0.39182,"NES":-0.60311,"nMoreExtreme":41571,"size":2,"leadingEdge":["ODAPH","TFAP2A"]} {"pathway":"GO_REGULATION_OF_TOOTH_MINERALIZATION","pval":0.76909,"padj":0.96082,"ES":-0.39184,"NES":-0.60473,"nMoreExtreme":37593,"size":3,"leadingEdge":["BCOR","ODAPH","TFAP2A"]} {"pathway":"GO_ENTERIC_NERVOUS_SYSTEM_DEVELOPMENT","pval":0.80978,"padj":0.96941,"ES":-0.45268,"NES":-0.60636,"nMoreExtreme":35725,"size":9,"leadingEdge":["KIF26A"]} {"pathway":"GO_HISTIDINE_CATABOLIC_PROCESS","pval":0.70423,"padj":0.9504,"ES":-0.4054,"NES":-0.60993,"nMoreExtreme":33771,"size":4,"leadingEdge":["CARNS1","CARNMT1","HNMT","AMDHD1"]} {"pathway":"GO_NUCLEOBASE_METABOLIC_PROCESS","pval":0.85917,"padj":0.97645,"ES":-0.46454,"NES":-0.61149,"nMoreExtreme":36859,"size":11,"leadingEdge":["TYMS","RRM1"]} {"pathway":"GO_SERINE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS","pval":0.77658,"padj":0.96098,"ES":-0.45184,"NES":-0.61391,"nMoreExtreme":34869,"size":8,"leadingEdge":["SHMT1","AMT"]} {"pathway":"GO_POST_ANAL_TAIL_MORPHOGENESIS","pval":0.85747,"padj":0.97645,"ES":-0.46702,"NES":-0.61476,"nMoreExtreme":36786,"size":11,"leadingEdge":["FZD3"]} {"pathway":"GO_REGULATION_OF_CYTOPLASMIC_TRANSLATIONAL_INITIATION","pval":0.69167,"padj":0.94995,"ES":-0.42234,"NES":-0.61549,"nMoreExtreme":32569,"size":5,"leadingEdge":["MTOR","YTHDF2","METTL3","NCK1","RPL13A"]} {"pathway":"GO_LYMPHOID_PROGENITOR_CELL_DIFFERENTIATION","pval":0.92643,"padj":0.987,"ES":-0.46338,"NES":-0.61557,"nMoreExtreme":37148,"size":16,"leadingEdge":["BCL2","BMP4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR","pval":0.6912,"padj":0.94995,"ES":-0.4229,"NES":-0.6163,"nMoreExtreme":32547,"size":5,"leadingEdge":["RPS7","UBB","MSX1","RPL26","RPL11"]} {"pathway":"GO_RESPONSE_TO_NITRIC_OXIDE","pval":0.92538,"padj":0.987,"ES":-0.4643,"NES":-0.6168,"nMoreExtreme":37106,"size":16,"leadingEdge":["CCNA2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CHOLESTEROL_EFFLUX","pval":0.81099,"padj":0.96978,"ES":-0.40266,"NES":-0.6198,"nMoreExtreme":40350,"size":2,"leadingEdge":["SREBF2","EGF"]} {"pathway":"GO_REGULATION_OF_GLIAL_CELL_MIGRATION","pval":0.92184,"padj":0.987,"ES":-0.46703,"NES":-0.62043,"nMoreExtreme":36964,"size":16,"leadingEdge":["CX3CR1","GPR183","TIAM1","TREM2","CCR2"]} {"pathway":"GO_PLATELET_DENSE_GRANULE_ORGANIZATION","pval":0.77417,"padj":0.96098,"ES":-0.45789,"NES":-0.62212,"nMoreExtreme":34761,"size":8,"leadingEdge":["F2RL3"]} {"pathway":"GO_ENDOCARDIAL_CUSHION_FORMATION","pval":0.92947,"padj":0.98762,"ES":-0.46607,"NES":-0.62296,"nMoreExtreme":36780,"size":17,"leadingEdge":["SNAI1","ENG"]} {"pathway":"GO_PERICARDIUM_DEVELOPMENT","pval":0.91596,"padj":0.987,"ES":-0.47176,"NES":-0.62671,"nMoreExtreme":36728,"size":16,"leadingEdge":["FLRT3","BMP2"]} {"pathway":"GO_REGULATION_OF_ENDOCYTIC_RECYCLING","pval":0.8282,"padj":0.97439,"ES":-0.47364,"NES":-0.62796,"nMoreExtreme":36072,"size":10,"leadingEdge":["SORL1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_GASTRULATION","pval":0.68249,"padj":0.94976,"ES":-0.43121,"NES":-0.62842,"nMoreExtreme":32137,"size":5,"leadingEdge":["LHX1","SCX","RACK1","TENM4","OSR1"]} {"pathway":"GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_POSTSYNAPTIC_MEMBRANE","pval":0.93167,"padj":0.98762,"ES":-0.46756,"NES":-0.62882,"nMoreExtreme":36484,"size":18,"leadingEdge":["LRRC7"]} {"pathway":"GO_MODULATION_OF_SIGNAL_TRANSDUCTION_IN_OTHER_ORGANISM","pval":0.68226,"padj":0.94976,"ES":-0.43149,"NES":-0.62883,"nMoreExtreme":32126,"size":5,"leadingEdge":["CALM1","SCRIB","CALM3","TNIP1","CALM2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION","pval":0.90244,"padj":0.98417,"ES":-0.47694,"NES":-0.63024,"nMoreExtreme":36619,"size":15,"leadingEdge":["RBM24","BMP4"]} {"pathway":"GO_CGMP_MEDIATED_SIGNALING","pval":0.98318,"padj":0.99955,"ES":-0.43999,"NES":-0.63159,"nMoreExtreme":35412,"size":26,"leadingEdge":["PDE3A","HTR2B","PDE2A","THBS1"]} {"pathway":"GO_LENS_FIBER_CELL_DIFFERENTIATION","pval":0.95739,"padj":0.9934,"ES":-0.45609,"NES":-0.63333,"nMoreExtreme":35834,"size":22,"leadingEdge":["MAF"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_ALKALOID","pval":0.95319,"padj":0.9929,"ES":-0.45917,"NES":-0.63761,"nMoreExtreme":35677,"size":22,"leadingEdge":["CCNA2","CRHBP","RAD51","BLM","RYR1","GSTM2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_GLUCONEOGENESIS","pval":0.8728,"padj":0.97746,"ES":-0.48561,"NES":-0.63852,"nMoreExtreme":36448,"size":13,"leadingEdge":["C1QTNF3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MEIOTIC_CELL_CYCLE","pval":0.90207,"padj":0.98417,"ES":-0.48253,"NES":-0.64102,"nMoreExtreme":36171,"size":16,"leadingEdge":["CDC25A","CDC25C","INSR"]} {"pathway":"GO_GERM_CELL_MIGRATION","pval":0.73336,"padj":0.9576,"ES":-0.46545,"NES":-0.64359,"nMoreExtreme":33474,"size":7,"leadingEdge":["CXADR"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE","pval":0.94301,"padj":0.98909,"ES":-0.46491,"NES":-0.64558,"nMoreExtreme":35296,"size":22,"leadingEdge":["TNFRSF11A","ADAM8","OSM","TNFSF11"]} {"pathway":"GO_SA_NODE_CELL_TO_ATRIAL_CARDIAC_MUSCLE_CELL_COMMUNICATION","pval":0.76458,"padj":0.96082,"ES":-0.476,"NES":-0.64673,"nMoreExtreme":34330,"size":8,"leadingEdge":["GJC1","CACNA1D","GJA5"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CREB_TRANSCRIPTION_FACTOR_ACTIVITY","pval":0.88647,"padj":0.98086,"ES":-0.49037,"NES":-0.64798,"nMoreExtreme":35971,"size":15,"leadingEdge":["ADCY1"]} {"pathway":"GO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_PRODUCTION","pval":0.97822,"padj":0.99901,"ES":-0.44403,"NES":-0.64873,"nMoreExtreme":34632,"size":28,"leadingEdge":["BRCA1","ADGRG1","C5","C5AR1","CCR2","NDRG2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CYCLIC_NUCLEOTIDE_PHOSPHODIESTERASE_ACTIVITY","pval":0.66945,"padj":0.94905,"ES":-0.43147,"NES":-0.64915,"nMoreExtreme":32103,"size":4,"leadingEdge":["RACK1","CALM1","CALM3","CALM2"]} {"pathway":"GO_RESPONSE_TO_PROSTAGLANDIN_E","pval":0.9153,"padj":0.987,"ES":-0.47932,"NES":-0.64939,"nMoreExtreme":35315,"size":19,"leadingEdge":["GNG2","TGFBR3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION","pval":0.85132,"padj":0.97645,"ES":-0.4953,"NES":-0.65132,"nMoreExtreme":36026,"size":12,"leadingEdge":["GFRA2","NLRP12"]} {"pathway":"GO_RESPONSE_TO_DIETARY_EXCESS","pval":0.88191,"padj":0.98086,"ES":-0.49375,"NES":-0.65244,"nMoreExtreme":35786,"size":15,"leadingEdge":["APPL2","ADRB1","BMP8A"]} {"pathway":"GO_REGULATION_OF_POSITIVE_CHEMOTAXIS","pval":0.94718,"padj":0.99093,"ES":-0.46261,"NES":-0.65278,"nMoreExtreme":34732,"size":24,"leadingEdge":["S1PR1"]} {"pathway":"GO_NOTCH_SIGNALING_INVOLVED_IN_HEART_DEVELOPMENT","pval":0.76099,"padj":0.96082,"ES":-0.48187,"NES":-0.65471,"nMoreExtreme":34169,"size":8,"leadingEdge":["SNAI1","HEY1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS","pval":0.93555,"padj":0.98762,"ES":-0.46818,"NES":-0.65527,"nMoreExtreme":34693,"size":23,"leadingEdge":["GHRL"]} {"pathway":"GO_SULFUR_COMPOUND_TRANSPORT","pval":0.98318,"padj":0.99955,"ES":-0.44006,"NES":-0.65762,"nMoreExtreme":33955,"size":31,"leadingEdge":["SLC25A10","SLC26A9","SLC9A3R1","RACGAP1"]} {"pathway":"GO_REGULATION_OF_RESPIRATORY_GASEOUS_EXCHANGE","pval":0.8676,"padj":0.97662,"ES":-0.49954,"NES":-0.65781,"nMoreExtreme":35693,"size":14,"leadingEdge":["PASK","NTSR1"]} {"pathway":"GO_ENDOPLASMIC_RETICULUM_TO_CYTOSOL_TRANSPORT","pval":0.96642,"padj":0.99537,"ES":-0.45105,"NES":-0.659,"nMoreExtreme":34214,"size":28,"leadingEdge":["DERL3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MUSCLE_CONTRACTION","pval":0.97719,"padj":0.99889,"ES":-0.44435,"NES":-0.65912,"nMoreExtreme":34017,"size":30,"leadingEdge":["GHRL","PROK2","ADRA2B","CHRM3"]} {"pathway":"GO_REGULATION_OF_DEVELOPMENTAL_PIGMENTATION","pval":0.84435,"padj":0.97458,"ES":-0.5017,"NES":-0.65973,"nMoreExtreme":35731,"size":12,"leadingEdge":["KITLG","BCL2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CIRCADIAN_RHYTHM","pval":0.75841,"padj":0.9603,"ES":-0.48578,"NES":-0.66001,"nMoreExtreme":34053,"size":8,"leadingEdge":["GHRL"]} {"pathway":"GO_HISTONE_H3_K4_DEMETHYLATION","pval":0.72677,"padj":0.95562,"ES":-0.47795,"NES":-0.66088,"nMoreExtreme":33173,"size":7,"leadingEdge":["JARID2"]} {"pathway":"GO_REGULATION_OF_FEEDING_BEHAVIOR","pval":0.80859,"padj":0.96881,"ES":-0.49958,"NES":-0.66235,"nMoreExtreme":35218,"size":10,"leadingEdge":["GHRL","RETN"]} {"pathway":"GO_POSITIVE_REGULATION_OF_GLUCOSE_METABOLIC_PROCESS","pval":0.8989,"padj":0.98387,"ES":-0.48893,"NES":-0.66241,"nMoreExtreme":34682,"size":19,"leadingEdge":["SLC45A3","INSR","IRS2","PPP1R3G"]} {"pathway":"GO_ESTABLISHMENT_OF_BLOOD_BRAIN_BARRIER","pval":0.75734,"padj":0.9603,"ES":-0.48786,"NES":-0.66285,"nMoreExtreme":34005,"size":8,"leadingEdge":["ADGRA2","ENG"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ERBB_SIGNALING_PATHWAY","pval":0.9606,"padj":0.9934,"ES":-0.45417,"NES":-0.66355,"nMoreExtreme":34008,"size":28,"leadingEdge":["AGR2","MMP9","HIP1"]} {"pathway":"GO_CELL_FATE_COMMITMENT_INVOLVED_IN_FORMATION_OF_PRIMARY_GERM_LAYER","pval":0.93369,"padj":0.98762,"ES":-0.46795,"NES":-0.66627,"nMoreExtreme":33890,"size":25,"leadingEdge":["SOX17","FZD7","FGFR1","ETV2","BMP4"]} {"pathway":"GO_REGULATION_OF_VESICLE_FUSION","pval":0.927,"padj":0.987,"ES":-0.47229,"NES":-0.66643,"nMoreExtreme":33992,"size":24,"leadingEdge":["SYT1"]} {"pathway":"GO_3_UTR_MEDIATED_MRNA_STABILIZATION","pval":0.8805,"padj":0.98072,"ES":-0.49941,"NES":-0.66753,"nMoreExtreme":34842,"size":17,"leadingEdge":["DAZL","RBM24"]} {"pathway":"GO_PROTEIN_MATURATION_BY_4FE_4S_CLUSTER_TRANSFER","pval":0.65826,"padj":0.94878,"ES":-0.45896,"NES":-0.66886,"nMoreExtreme":30996,"size":5,"leadingEdge":["YAE1","CIAO2A","CIAO2B","ISCA2","LTO1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION_INVOLVED_IN_PHOSPHOLIPASE_C_ACTIVATING_G_PROTEIN_COUPLED_SIGNALING_PATHWAY","pval":0.90229,"padj":0.98417,"ES":-0.48586,"NES":-0.66905,"nMoreExtreme":34074,"size":21,"leadingEdge":["S1PR1","F2RL3"]} {"pathway":"GO_CELL_DIFFERENTIATION_IN_SPINAL_CORD","pval":0.96372,"padj":0.995,"ES":-0.45111,"NES":-0.66916,"nMoreExtreme":33548,"size":30,"leadingEdge":["TAL1","OLIG2","GDF7","IFT172"]} {"pathway":"GO_ESTABLISHMENT_OR_MAINTENANCE_OF_CYTOSKELETON_POLARITY","pval":0.87244,"padj":0.97746,"ES":-0.50371,"NES":-0.66916,"nMoreExtreme":34983,"size":16,"leadingEdge":["KIF2C","LMNA"]} {"pathway":"GO_POSITIVE_REGULATION_OF_HIGH_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY","pval":0.65254,"padj":0.94878,"ES":-0.44489,"NES":-0.66935,"nMoreExtreme":31292,"size":4,"leadingEdge":["CACNB3","CACNB2","CACNA2D1","NIPSNAP2"]} {"pathway":"GO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_SIGNALING_PATHWAY","pval":0.98144,"padj":0.99935,"ES":-0.4401,"NES":-0.67159,"nMoreExtreme":32991,"size":34,"leadingEdge":["NRP1","DLL1","ADGRA2"]} {"pathway":"GO_REGULATION_OF_NATURAL_KILLER_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE","pval":0.98971,"padj":1,"ES":-0.50536,"NES":-0.67334,"nMoreExtreme":49449,"size":1,"leadingEdge":["PGLYRP2"]} {"pathway":"GO_REGULATION_OF_RETROGRADE_PROTEIN_TRANSPORT_ER_TO_CYTOSOL","pval":0.84433,"padj":0.97458,"ES":-0.51214,"NES":-0.6734,"nMoreExtreme":35259,"size":13,"leadingEdge":["DERL3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_DENDRITE_DEVELOPMENT","pval":0.8902,"padj":0.98144,"ES":-0.49339,"NES":-0.67352,"nMoreExtreme":33993,"size":20,"leadingEdge":["FSTL4","NGEF","DNM3"]} {"pathway":"GO_HORMONE_CATABOLIC_PROCESS","pval":0.8335,"padj":0.97443,"ES":-0.51244,"NES":-0.67386,"nMoreExtreme":35272,"size":12,"leadingEdge":["ACE","SULT1E1","CYP19A1"]} {"pathway":"GO_URONIC_ACID_METABOLIC_PROCESS","pval":0.68843,"padj":0.94995,"ES":-0.43672,"NES":-0.674,"nMoreExtreme":33650,"size":3,"leadingEdge":["UGT1A1","PRKCE","ABHD10"]} {"pathway":"GO_INNERVATION","pval":0.88223,"padj":0.98086,"ES":-0.49801,"NES":-0.67472,"nMoreExtreme":34039,"size":19,"leadingEdge":["NRP1"]} {"pathway":"GO_NEURON_CELL_CELL_ADHESION","pval":0.81791,"padj":0.97133,"ES":-0.51299,"NES":-0.67526,"nMoreExtreme":35089,"size":11,"leadingEdge":["CDK5R1","NLGN2","NINJ2"]} {"pathway":"GO_SCLEROTOME_DEVELOPMENT","pval":0.74917,"padj":0.9603,"ES":-0.439,"NES":-0.67573,"nMoreExtreme":37274,"size":2,"leadingEdge":["SCX","SFRP2"]} {"pathway":"GO_ANTERIOR_COMMISSURE_MORPHOGENESIS","pval":0.6462,"padj":0.94878,"ES":-0.4504,"NES":-0.67763,"nMoreExtreme":30988,"size":4,"leadingEdge":["PLXNA4","TSKU","FBXO45","NFIB"]} {"pathway":"GO_AMYLOID_PRECURSOR_PROTEIN_BIOSYNTHETIC_PROCESS","pval":0.81605,"padj":0.971,"ES":-0.51512,"NES":-0.67807,"nMoreExtreme":35009,"size":11,"leadingEdge":["NECAB2"]} {"pathway":"GO_REGULATION_OF_CAMP_DEPENDENT_PROTEIN_KINASE_ACTIVITY","pval":0.85495,"padj":0.97645,"ES":-0.5137,"NES":-0.67881,"nMoreExtreme":34692,"size":15,"leadingEdge":["PKIB"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY","pval":0.79697,"padj":0.96646,"ES":-0.51279,"NES":-0.67986,"nMoreExtreme":34712,"size":10,"leadingEdge":["MMRN2"]} {"pathway":"GO_ESTABLISHMENT_OF_SPINDLE_ORIENTATION","pval":0.92056,"padj":0.987,"ES":-0.47228,"NES":-0.68399,"nMoreExtreme":32865,"size":27,"leadingEdge":["NDC80","CENPA","KIF25"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_LIPOPROTEIN_PARTICLE_STIMULUS","pval":0.93409,"padj":0.98762,"ES":-0.46489,"NES":-0.6842,"nMoreExtreme":32793,"size":29,"leadingEdge":["LPL","CD9","ADTRP"]} {"pathway":"GO_POSITIVE_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS","pval":0.8119,"padj":0.97053,"ES":-0.51978,"NES":-0.6842,"nMoreExtreme":34831,"size":11,"leadingEdge":["SLC45A3"]} {"pathway":"GO_SERINE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS","pval":0.86013,"padj":0.97645,"ES":-0.51236,"NES":-0.68484,"nMoreExtreme":34036,"size":17,"leadingEdge":["SERINC5","SHMT1"]} {"pathway":"GO_PROTEIN_INSERTION_INTO_MITOCHONDRIAL_MEMBRANE_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY","pval":0.91874,"padj":0.987,"ES":-0.47316,"NES":-0.68526,"nMoreExtreme":32800,"size":27,"leadingEdge":["E2F1","TP73","BCL2"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_PROSTAGLANDIN_E_STIMULUS","pval":0.84788,"padj":0.97587,"ES":-0.51941,"NES":-0.68636,"nMoreExtreme":34405,"size":15,"leadingEdge":["GNG2"]} {"pathway":"GO_MICROVILLUS_ASSEMBLY","pval":0.85326,"padj":0.97645,"ES":-0.51704,"NES":-0.68686,"nMoreExtreme":34214,"size":16,"leadingEdge":["ATP8B1","FSCN1","SLC9A3R1"]} {"pathway":"GO_LEUKOCYTE_MIGRATION_INVOLVED_IN_INFLAMMATORY_RESPONSE","pval":0.79268,"padj":0.96486,"ES":-0.51814,"NES":-0.68695,"nMoreExtreme":34525,"size":10,"leadingEdge":["ADAM8"]} {"pathway":"GO_REGULATION_OF_LAMELLIPODIUM_ASSEMBLY","pval":0.93275,"padj":0.98762,"ES":-0.4643,"NES":-0.68872,"nMoreExtreme":32470,"size":30,"leadingEdge":["FSCN1"]} {"pathway":"GO_REGULATION_OF_EXTRACELLULAR_MATRIX_DISASSEMBLY","pval":0.84485,"padj":0.97458,"ES":-0.5217,"NES":-0.68938,"nMoreExtreme":34282,"size":15,"leadingEdge":["FSCN1","MELTF"]} {"pathway":"GO_SKELETAL_MUSCLE_ADAPTATION","pval":0.8572,"padj":0.97645,"ES":-0.51308,"NES":-0.69004,"nMoreExtreme":33568,"size":18,"leadingEdge":["MYOZ2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ENDOCYTIC_RECYCLING","pval":0.64671,"padj":0.94878,"ES":-0.47365,"NES":-0.69027,"nMoreExtreme":30452,"size":5,"leadingEdge":["SORL1"]} {"pathway":"GO_REGULATION_OF_MYOSIN_LIGHT_CHAIN_PHOSPHATASE_ACTIVITY","pval":0.71404,"padj":0.9532,"ES":-0.49925,"NES":-0.69033,"nMoreExtreme":32592,"size":7,"leadingEdge":["NUAK1"]} {"pathway":"GO_RETINOL_METABOLIC_PROCESS","pval":0.86742,"padj":0.97662,"ES":-0.50581,"NES":-0.69048,"nMoreExtreme":33123,"size":20,"leadingEdge":["PLB1","DHRS3","RBP4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_VOLTAGE_GATED_POTASSIUM_CHANNEL_ACTIVITY","pval":0.67877,"padj":0.94976,"ES":-0.48763,"NES":-0.69052,"nMoreExtreme":31448,"size":6,"leadingEdge":["AKAP6","TREM2"]} {"pathway":"GO_PENTOSE_PHOSPHATE_SHUNT_NON_OXIDATIVE_BRANCH","pval":0.64652,"padj":0.94878,"ES":-0.47402,"NES":-0.6908,"nMoreExtreme":30443,"size":5,"leadingEdge":["RPE","SHPK","TALDO1","TKT","RPIA"]} {"pathway":"GO_BROWN_FAT_CELL_DIFFERENTIATION","pval":0.92147,"padj":0.987,"ES":-0.46975,"NES":-0.69135,"nMoreExtreme":32350,"size":29,"leadingEdge":["LAMB3","ADRB1"]} {"pathway":"GO_PHOSPHATE_ION_TRANSMEMBRANE_TRANSPORT","pval":0.81899,"padj":0.97133,"ES":-0.52634,"NES":-0.69213,"nMoreExtreme":34658,"size":12,"leadingEdge":["ANKH","SLC20A1","SLC25A10"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_GLUTAMATE_SECRETION","pval":0.96149,"padj":0.99357,"ES":-0.52019,"NES":-0.6931,"nMoreExtreme":48039,"size":1,"leadingEdge":["ADORA1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT","pval":0.86842,"padj":0.97662,"ES":-0.50374,"NES":-0.69367,"nMoreExtreme":32795,"size":21,"leadingEdge":["ASIC1","PRKN","RGS4"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_PROSTAGLANDIN_STIMULUS","pval":0.84919,"padj":0.97618,"ES":-0.51941,"NES":-0.69427,"nMoreExtreme":33603,"size":17,"leadingEdge":["GNG2"]} {"pathway":"GO_GRANULOCYTE_DIFFERENTIATION","pval":0.91438,"padj":0.98698,"ES":-0.47233,"NES":-0.69514,"nMoreExtreme":32101,"size":29,"leadingEdge":["TESC","TAL1"]} {"pathway":"GO_REPLICATIVE_SENESCENCE","pval":0.80395,"padj":0.96671,"ES":-0.52863,"NES":-0.69585,"nMoreExtreme":34490,"size":11,"leadingEdge":["CHEK1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SECRETION","pval":0.64319,"padj":0.94878,"ES":-0.47819,"NES":-0.69688,"nMoreExtreme":30286,"size":5,"leadingEdge":["GHRL"]} {"pathway":"GO_CALCIUM_INDEPENDENT_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES","pval":0.82374,"padj":0.97439,"ES":-0.53042,"NES":-0.69744,"nMoreExtreme":34399,"size":13,"leadingEdge":["CLDN10","BMP2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION","pval":0.88484,"padj":0.98086,"ES":-0.49029,"NES":-0.69808,"nMoreExtreme":32117,"size":25,"leadingEdge":["FBXO5","BLM","DONSON"]} {"pathway":"GO_PROTEIN_DEMETHYLATION","pval":0.9023,"padj":0.98417,"ES":-0.47788,"NES":-0.69819,"nMoreExtreme":31944,"size":28,"leadingEdge":["JARID2"]} {"pathway":"GO_NUCLEAR_MIGRATION","pval":0.85121,"padj":0.97645,"ES":-0.51535,"NES":-0.6982,"nMoreExtreme":32842,"size":19,"leadingEdge":["FHOD1","SLC9A3R1","SYNE3"]} {"pathway":"GO_SEQUESTERING_OF_TRIGLYCERIDE","pval":0.81299,"padj":0.97053,"ES":-0.53301,"NES":-0.7009,"nMoreExtreme":34404,"size":12,"leadingEdge":["LPL"]} {"pathway":"GO_POSITIVE_REGULATION_OF_LAMELLIPODIUM_ASSEMBLY","pval":0.84395,"padj":0.97458,"ES":-0.52116,"NES":-0.70091,"nMoreExtreme":33049,"size":18,"leadingEdge":["FSCN1"]} {"pathway":"GO_LATERAL_SPROUTING_FROM_AN_EPITHELIUM","pval":0.78386,"padj":0.96311,"ES":-0.52923,"NES":-0.70166,"nMoreExtreme":34141,"size":10,"leadingEdge":["CELSR1","BMP4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MUSCLE_ADAPTATION","pval":0.62797,"padj":0.94878,"ES":-0.46644,"NES":-0.70176,"nMoreExtreme":30114,"size":4,"leadingEdge":["MIR17HG","AIF1","MTOR"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_INVOLVED_IN_CELLULAR_RESPONSE_TO_CHEMICAL_STIMULUS","pval":0.84584,"padj":0.97477,"ES":-0.51906,"NES":-0.70323,"nMoreExtreme":32635,"size":19,"leadingEdge":["RUNX2","BMP2"]} {"pathway":"GO_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE","pval":0.92342,"padj":0.987,"ES":-0.46448,"NES":-0.70408,"nMoreExtreme":31301,"size":33,"leadingEdge":["TNFRSF11A","ADAM8","OSM","TNFSF11"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_POSTSYNAPTIC_MEMBRANE","pval":0.9177,"padj":0.987,"ES":-0.46752,"NES":-0.7041,"nMoreExtreme":31420,"size":32,"leadingEdge":["LRRC7"]} {"pathway":"GO_ACTIVATION_OF_ADENYLATE_CYCLASE_ACTIVITY","pval":0.86902,"padj":0.97662,"ES":-0.49903,"NES":-0.70417,"nMoreExtreme":31866,"size":24,"leadingEdge":["ADORA3","ADCY1","ADCY4","ADRB1","LGR4"]} {"pathway":"GO_DOPAMINE_TRANSPORT","pval":0.8749,"padj":0.97837,"ES":-0.49456,"NES":-0.70417,"nMoreExtreme":31756,"size":25,"leadingEdge":["SYT1","SYT6","SNCG"]} {"pathway":"GO_PROTEIN_C_LINKED_GLYCOSYLATION","pval":0.63885,"padj":0.94878,"ES":-0.48368,"NES":-0.70489,"nMoreExtreme":30082,"size":5,"leadingEdge":["DPM3","DPY19L3","DPY19L1","DPY19L2P2","DPY19L4"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_UBIQUITIN_PROTEIN_TRANSFERASE_ACTIVITY","pval":0.82907,"padj":0.97439,"ES":-0.53363,"NES":-0.70514,"nMoreExtreme":33642,"size":15,"leadingEdge":["MAD2L1","FBXO5"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELL_ADHESION_MEDIATED_BY_INTEGRIN","pval":0.78237,"padj":0.96269,"ES":-0.53196,"NES":-0.70528,"nMoreExtreme":34076,"size":10,"leadingEdge":["PDE3B","NEXMIF"]} {"pathway":"GO_DNA_LIGATION","pval":0.83552,"padj":0.97443,"ES":-0.52784,"NES":-0.70553,"nMoreExtreme":33062,"size":17,"leadingEdge":["TOP2A","RAD51","HMGB2"]} {"pathway":"GO_DERMATAN_SULFATE_BIOSYNTHETIC_PROCESS","pval":0.79742,"padj":0.96646,"ES":-0.5364,"NES":-0.70608,"nMoreExtreme":34210,"size":11,"leadingEdge":["VCAN","UST"]} {"pathway":"GO_LUNG_CELL_DIFFERENTIATION","pval":0.83736,"padj":0.97458,"ES":-0.52514,"NES":-0.70626,"nMoreExtreme":32791,"size":18,"leadingEdge":["AGR2"]} {"pathway":"GO_REGULATION_OF_T_CELL_DIFFERENTIATION_IN_THYMUS","pval":0.83731,"padj":0.97458,"ES":-0.52518,"NES":-0.70632,"nMoreExtreme":32789,"size":18,"leadingEdge":["ADAM8","VNN1"]} {"pathway":"GO_DERMATAN_SULFATE_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS","pval":0.82244,"padj":0.9738,"ES":-0.53639,"NES":-0.70635,"nMoreExtreme":33835,"size":14,"leadingEdge":["VCAN","UST"]} {"pathway":"GO_INTERLEUKIN_6_BIOSYNTHETIC_PROCESS","pval":0.84027,"padj":0.97458,"ES":-0.52191,"NES":-0.70709,"nMoreExtreme":32420,"size":19,"leadingEdge":["GHRL","NLRP12"]} {"pathway":"GO_RESPONSE_TO_PARATHYROID_HORMONE","pval":0.70617,"padj":0.9508,"ES":-0.51168,"NES":-0.70751,"nMoreExtreme":32233,"size":7,"leadingEdge":["WNT10B"]} {"pathway":"GO_REGULATION_OF_POSTSYNAPTIC_MEMBRANE_ORGANIZATION","pval":0.81555,"padj":0.971,"ES":-0.53819,"NES":-0.70766,"nMoreExtreme":34057,"size":13,"leadingEdge":["FZD9"]} {"pathway":"GO_BLASTODERM_SEGMENTATION","pval":0.82636,"padj":0.97439,"ES":-0.53563,"NES":-0.70778,"nMoreExtreme":33532,"size":15,"leadingEdge":["NRP1","PCSK6"]} {"pathway":"GO_DETECTION_OF_CHEMICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_TASTE","pval":0.67051,"padj":0.94905,"ES":-0.50086,"NES":-0.70924,"nMoreExtreme":31065,"size":6,"leadingEdge":["PKD1L3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_COLLAGEN_BIOSYNTHETIC_PROCESS","pval":0.84515,"padj":0.97458,"ES":-0.51555,"NES":-0.70994,"nMoreExtreme":31916,"size":21,"leadingEdge":["MYB","BMP4","ENG"]} {"pathway":"GO_REGULATION_OF_GONAD_DEVELOPMENT","pval":0.81904,"padj":0.97133,"ES":-0.53926,"NES":-0.71011,"nMoreExtreme":33695,"size":14,"leadingEdge":["INSR","RETN"]} {"pathway":"GO_SUBSTRATE_INDEPENDENT_TELENCEPHALIC_TANGENTIAL_MIGRATION","pval":0.62078,"padj":0.94878,"ES":-0.47281,"NES":-0.71135,"nMoreExtreme":29769,"size":4,"leadingEdge":["CNTN2","ARL13B","NRG1","FEZF2"]} {"pathway":"GO_MEIOTIC_ATTACHMENT_OF_TELOMERE_TO_NUCLEAR_ENVELOPE","pval":0.93447,"padj":0.98762,"ES":-0.53401,"NES":-0.7115,"nMoreExtreme":46689,"size":1,"leadingEdge":["SUN1"]} {"pathway":"GO_PARACRINE_SIGNALING","pval":0.6351,"padj":0.94878,"ES":-0.48877,"NES":-0.7123,"nMoreExtreme":29905,"size":5,"leadingEdge":["TNFSF11"]} {"pathway":"GO_REGULATION_OF_ACTIN_CYTOSKELETON_REORGANIZATION","pval":0.90536,"padj":0.98417,"ES":-0.47047,"NES":-0.71316,"nMoreExtreme":30689,"size":33,"leadingEdge":["NRP1","BAIAP2"]} {"pathway":"GO_REGULATION_OF_CYCLASE_ACTIVITY","pval":0.8974,"padj":0.98354,"ES":-0.47434,"NES":-0.71437,"nMoreExtreme":30725,"size":32,"leadingEdge":["CACNA1D","GABBR2","CCR2","GNG7"]} {"pathway":"GO_MALE_MEIOSIS_I","pval":0.82346,"padj":0.97439,"ES":-0.53818,"NES":-0.71495,"nMoreExtreme":33019,"size":16,"leadingEdge":["DMC1","MYBL1","TRIP13"]} {"pathway":"GO_REGULATION_OF_FEMALE_GONAD_DEVELOPMENT","pval":0.77668,"padj":0.96098,"ES":-0.53927,"NES":-0.71497,"nMoreExtreme":33828,"size":10,"leadingEdge":["INSR","RETN"]} {"pathway":"GO_CAP_INDEPENDENT_TRANSLATIONAL_INITIATION","pval":0.63325,"padj":0.94878,"ES":-0.49121,"NES":-0.71586,"nMoreExtreme":29818,"size":5,"leadingEdge":["YTHDF2","EIF4EBP1","RBM4","METTL3","NCK1"]} {"pathway":"GO_OXYGEN_METABOLIC_PROCESS","pval":0.64109,"padj":0.94878,"ES":-0.46414,"NES":-0.7163,"nMoreExtreme":31336,"size":3,"leadingEdge":["LIPT2","RNF34","ME3"]} {"pathway":"GO_RESPONSE_TO_NERVE_GROWTH_FACTOR","pval":0.97444,"padj":0.9981,"ES":-0.43877,"NES":-0.71642,"nMoreExtreme":29620,"size":46,"leadingEdge":["E2F1","KAT2A","FOXO3","NTF3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MEMBRANE_DEPOLARIZATION","pval":0.66723,"padj":0.94905,"ES":-0.50592,"NES":-0.71642,"nMoreExtreme":30913,"size":6,"leadingEdge":["BCL2","FZD9"]} {"pathway":"GO_RESPONSE_TO_PLATELET_DERIVED_GROWTH_FACTOR","pval":0.8283,"padj":0.97439,"ES":-0.52892,"NES":-0.71659,"nMoreExtreme":31958,"size":19,"leadingEdge":["CCNA2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION","pval":0.86925,"padj":0.97662,"ES":-0.491,"NES":-0.71737,"nMoreExtreme":30774,"size":28,"leadingEdge":["MMP9","DLL1"]} {"pathway":"GO_ARACHIDONIC_ACID_SECRETION","pval":0.81651,"padj":0.971,"ES":-0.54308,"NES":-0.71764,"nMoreExtreme":33132,"size":15,"leadingEdge":["ACE","NTSR1","NMB"]} {"pathway":"GO_CATECHOLAMINE_SECRETION","pval":0.88525,"padj":0.98086,"ES":-0.48038,"NES":-0.71787,"nMoreExtreme":30573,"size":31,"leadingEdge":["SYT1","SYT6","STX1A","NISCH","ADRA2B","SNCG","FFAR3"]} {"pathway":"GO_REGULATION_OF_LYASE_ACTIVITY","pval":0.89339,"padj":0.98267,"ES":-0.47433,"NES":-0.71901,"nMoreExtreme":30283,"size":33,"leadingEdge":["CACNA1D","GABBR2","CCR2","GNG7"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION","pval":0.8313,"padj":0.97439,"ES":-0.52298,"NES":-0.72018,"nMoreExtreme":31393,"size":21,"leadingEdge":["GHRL","PROK2","ADRA2B","CHRM3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CHEMOTAXIS","pval":0.97908,"padj":0.99901,"ES":-0.43539,"NES":-0.72114,"nMoreExtreme":29208,"size":49,"leadingEdge":["KLRK1","NRP1","SEMA6B","C5","SEMA3G","SEMA6C","CYP19A1","SEMA4C","THBS1"]} {"pathway":"GO_NUCLEOSIDE_TRANSPORT","pval":0.70015,"padj":0.94995,"ES":-0.52198,"NES":-0.72175,"nMoreExtreme":31958,"size":7,"leadingEdge":["SLC28A3"]} {"pathway":"GO_EPINEPHRINE_TRANSPORT","pval":0.63499,"padj":0.94878,"ES":-0.46792,"NES":-0.72214,"nMoreExtreme":31038,"size":3,"leadingEdge":["ADRA2B"]} {"pathway":"GO_HEPATOCYTE_DIFFERENTIATION","pval":0.803,"padj":0.96646,"ES":-0.54952,"NES":-0.72255,"nMoreExtreme":33533,"size":13,"leadingEdge":["E2F8","E2F7"]} {"pathway":"GO_HISTONE_SERINE_PHOSPHORYLATION","pval":0.77197,"padj":0.96084,"ES":-0.54531,"NES":-0.72297,"nMoreExtreme":33623,"size":10,"leadingEdge":["AURKB"]} {"pathway":"GO_CELL_CELL_SIGNALING_INVOLVED_IN_CARDIAC_CONDUCTION","pval":0.85033,"padj":0.97645,"ES":-0.50369,"NES":-0.72303,"nMoreExtreme":30627,"size":26,"leadingEdge":["SCN4B","CXADR","GJC1","CACNA1D"]} {"pathway":"GO_DOPAMINE_SECRETION","pval":0.81727,"padj":0.97133,"ES":-0.53789,"NES":-0.72341,"nMoreExtreme":32004,"size":18,"leadingEdge":["SYT1","SYT6","SNCG"]} {"pathway":"GO_LENS_DEVELOPMENT_IN_CAMERA_TYPE_EYE","pval":0.98205,"padj":0.99935,"ES":-0.43343,"NES":-0.72386,"nMoreExtreme":28828,"size":51,"leadingEdge":["MAF","NHS","NECTIN1","SKI","BMP4","BFSP1"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_PARATHYROID_HORMONE_STIMULUS","pval":0.6639,"padj":0.94905,"ES":-0.51168,"NES":-0.72457,"nMoreExtreme":30759,"size":6,"leadingEdge":["WNT10B"]} {"pathway":"GO_SUBSTRATE_DEPENDENT_CELL_MIGRATION","pval":0.85275,"padj":0.97645,"ES":-0.50032,"NES":-0.72459,"nMoreExtreme":30444,"size":27,"leadingEdge":["ADAM8","NRP1"]} {"pathway":"GO_RESPONSE_TO_PHEROMONE","pval":0.70077,"padj":0.94995,"ES":-0.47079,"NES":-0.72467,"nMoreExtreme":34866,"size":2,"leadingEdge":["TMEM145","GPR180"]} {"pathway":"GO_STRIATED_MUSCLE_ADAPTATION","pval":0.88164,"padj":0.98086,"ES":-0.47852,"NES":-0.72536,"nMoreExtreme":29885,"size":33,"leadingEdge":["MYOZ2"]} {"pathway":"GO_DENSE_CORE_GRANULE_EXOCYTOSIS","pval":0.75124,"padj":0.9603,"ES":-0.54222,"NES":-0.7263,"nMoreExtreme":33142,"size":9,"leadingEdge":["SYT6"]} {"pathway":"GO_PYRUVATE_FAMILY_AMINO_ACID_METABOLIC_PROCESS","pval":0.91246,"padj":0.98592,"ES":-0.54524,"NES":-0.72647,"nMoreExtreme":45589,"size":1,"leadingEdge":["GPT2"]} {"pathway":"GO_C4_DICARBOXYLATE_TRANSPORT","pval":0.81333,"padj":0.97053,"ES":-0.54055,"NES":-0.72698,"nMoreExtreme":31850,"size":18,"leadingEdge":["SLC25A10","NTSR1","LRRC8E"]} {"pathway":"GO_BRANCHING_INVOLVED_IN_BLOOD_VESSEL_MORPHOGENESIS","pval":0.83272,"padj":0.97443,"ES":-0.51547,"NES":-0.72736,"nMoreExtreme":30535,"size":24,"leadingEdge":["NRP1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SEQUESTERING_OF_CALCIUM_ION","pval":0.79802,"padj":0.96646,"ES":-0.55371,"NES":-0.72806,"nMoreExtreme":33325,"size":13,"leadingEdge":["TRDN","NTSR1","GSTM2"]} {"pathway":"GO_NEGATIVE_CHEMOTAXIS","pval":0.9039,"padj":0.98417,"ES":-0.46586,"NES":-0.7291,"nMoreExtreme":29271,"size":38,"leadingEdge":["SEMA6B","SEMA3G","SEMA6C","FLRT3","SEMA4C"]} {"pathway":"GO_PRIMARY_ALCOHOL_METABOLIC_PROCESS","pval":0.93889,"padj":0.98783,"ES":-0.45127,"NES":-0.72921,"nMoreExtreme":28930,"size":44,"leadingEdge":["PLB1","DHRS3","RBP4","BMP6","ALDH2","AKR7A2","BMP2"]} {"pathway":"GO_ERBB2_SIGNALING_PATHWAY","pval":0.84424,"padj":0.97458,"ES":-0.50367,"NES":-0.72944,"nMoreExtreme":30140,"size":27,"leadingEdge":["HBEGF","PRKCA","MATK"]} {"pathway":"GO_CEREBRAL_CORTEX_GABAERGIC_INTERNEURON_DEVELOPMENT","pval":0.62716,"padj":0.94878,"ES":-0.47279,"NES":-0.72965,"nMoreExtreme":30655,"size":3,"leadingEdge":["CNTN2","RAC3","FEZF2"]} {"pathway":"GO_NUCLEOSIDE_SALVAGE","pval":0.80025,"padj":0.96646,"ES":-0.55496,"NES":-0.73079,"nMoreExtreme":32922,"size":14,"leadingEdge":["TK1","PRTFDC1"]} {"pathway":"GO_ENDOTHELIAL_CELL_CHEMOTAXIS","pval":0.82478,"padj":0.97439,"ES":-0.52226,"NES":-0.73097,"nMoreExtreme":30585,"size":23,"leadingEdge":["NRP1","PLEKHG5","FGFR1","THBS1"]} {"pathway":"GO_RESPONSE_TO_CGMP","pval":0.62573,"padj":0.94878,"ES":-0.50159,"NES":-0.73099,"nMoreExtreme":29464,"size":5,"leadingEdge":["PDE3A","PDE2A"]} {"pathway":"GO_REGULATION_OF_SPINDLE_ASSEMBLY","pval":0.835,"padj":0.97443,"ES":-0.50995,"NES":-0.73201,"nMoreExtreme":30075,"size":26,"leadingEdge":["SPAG5","PLK1"]} {"pathway":"GO_MARGINAL_ZONE_B_CELL_DIFFERENTIATION","pval":0.72565,"padj":0.95562,"ES":-0.53919,"NES":-0.73259,"nMoreExtreme":32582,"size":8,"leadingEdge":["DLL1"]} {"pathway":"GO_HEPARAN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS","pval":0.85436,"padj":0.97645,"ES":-0.49158,"NES":-0.73461,"nMoreExtreme":29506,"size":31,"leadingEdge":["XYLT1","HS3ST1"]} {"pathway":"GO_GLIAL_CELL_FATE_SPECIFICATION","pval":0.62149,"padj":0.94878,"ES":-0.47638,"NES":-0.7352,"nMoreExtreme":30378,"size":3,"leadingEdge":["OLIG2"]} {"pathway":"GO_NUCLEOSIDE_MONOPHOSPHATE_PHOSPHORYLATION","pval":0.79502,"padj":0.96627,"ES":-0.5592,"NES":-0.73637,"nMoreExtreme":32707,"size":14,"leadingEdge":["AK1","AK7"]} {"pathway":"GO_PHOSPHATE_ION_TRANSPORT","pval":0.807,"padj":0.96769,"ES":-0.53953,"NES":-0.73651,"nMoreExtreme":30816,"size":20,"leadingEdge":["ANKH","SLC20A1","SLC25A10","FGFR1","SLC37A2","ROS1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS","pval":0.79797,"padj":0.96646,"ES":-0.55767,"NES":-0.73691,"nMoreExtreme":32380,"size":15,"leadingEdge":["IRS2"]} {"pathway":"GO_REGULATION_OF_FATTY_ACID_BETA_OXIDATION","pval":0.79797,"padj":0.96646,"ES":-0.55767,"NES":-0.73691,"nMoreExtreme":32380,"size":15,"leadingEdge":["IRS2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE","pval":0.86673,"padj":0.97662,"ES":-0.48297,"NES":-0.73701,"nMoreExtreme":29135,"size":34,"leadingEdge":["CDC45","CDC6","CCNE1","LSM11"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELLULAR_CARBOHYDRATE_METABOLIC_PROCESS","pval":0.86361,"padj":0.97662,"ES":-0.48403,"NES":-0.73862,"nMoreExtreme":29030,"size":34,"leadingEdge":["SLC45A3","INSR","HRH1","NTSR1","IRS2","PPP1R3G"]} {"pathway":"GO_REGULATION_OF_SKELETAL_MUSCLE_CELL_DIFFERENTIATION","pval":0.79766,"padj":0.96646,"ES":-0.553,"NES":-0.73916,"nMoreExtreme":31564,"size":17,"leadingEdge":["RBM24"]} {"pathway":"GO_PYRIMIDINE_NUCLEOBASE_METABOLIC_PROCESS","pval":0.62131,"padj":0.94878,"ES":-0.50737,"NES":-0.73941,"nMoreExtreme":29256,"size":5,"leadingEdge":["TYMS","RRM1"]} {"pathway":"GO_MEMBRANE_LIPID_CATABOLIC_PROCESS","pval":0.83118,"padj":0.97439,"ES":-0.50621,"NES":-0.73959,"nMoreExtreme":29426,"size":28,"leadingEdge":["SGPL1"]} {"pathway":"GO_BRAIN_DERIVED_NEUROTROPHIC_FACTOR_RECEPTOR_SIGNALING_PATHWAY","pval":0.65713,"padj":0.94878,"ES":-0.5235,"NES":-0.74131,"nMoreExtreme":30445,"size":6,"leadingEdge":["FSTL4"]} {"pathway":"GO_REGULATION_OF_NUCLEAR_CELL_CYCLE_DNA_REPLICATION","pval":0.78984,"padj":0.96445,"ES":-0.56376,"NES":-0.74238,"nMoreExtreme":32494,"size":14,"leadingEdge":["CDT1","FGFR1","CDC7"]} {"pathway":"GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_DIFFERENTIATION","pval":0.84725,"padj":0.97561,"ES":-0.4906,"NES":-0.74367,"nMoreExtreme":28719,"size":33,"leadingEdge":["DLL1","PARP2","AKAP6","FZD7","KAT2A","BMP4","BMP2","RGS4"]} {"pathway":"GO_REGULATION_OF_INOSITOL_1_4_5_TRISPHOSPHATE_SENSITIVE_CALCIUM_RELEASE_CHANNEL_ACTIVITY","pval":0.61919,"padj":0.94878,"ES":-0.51057,"NES":-0.74406,"nMoreExtreme":29156,"size":5,"leadingEdge":["MYO5A"]} {"pathway":"GO_GLIAL_CELL_FATE_COMMITMENT","pval":0.75765,"padj":0.9603,"ES":-0.56365,"NES":-0.74729,"nMoreExtreme":32999,"size":10,"leadingEdge":["TAL1","OLIG2"]} {"pathway":"GO_VENTRICULAR_SEPTUM_DEVELOPMENT","pval":0.9852,"padj":0.99994,"ES":-0.4298,"NES":-0.74761,"nMoreExtreme":26766,"size":62,"leadingEdge":["TGFBR3","HEY1","BMP4","GJA5"]} {"pathway":"GO_TETRAHYDROFOLATE_INTERCONVERSION","pval":0.74011,"padj":0.95908,"ES":-0.55888,"NES":-0.74863,"nMoreExtreme":32651,"size":9,"leadingEdge":["TYMS","SHMT1"]} {"pathway":"GO_HISTONE_H3_ACETYLATION","pval":0.95516,"padj":0.9934,"ES":-0.44103,"NES":-0.749,"nMoreExtreme":27327,"size":55,"leadingEdge":["BRCA1","JADE1","CHEK1","KAT2A"]} {"pathway":"GO_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION","pval":0.89093,"padj":0.98188,"ES":-0.46615,"NES":-0.74975,"nMoreExtreme":27746,"size":43,"leadingEdge":["GHRL","PROK2","ADRA2B","CALCRL","CHRM3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_DNA_REPAIR","pval":0.8415,"padj":0.97458,"ES":-0.49134,"NES":-0.74978,"nMoreExtreme":28287,"size":34,"leadingEdge":["POLQ","AUNIP","FANCB","BLM"]} {"pathway":"GO_MAINTENANCE_OF_ORGANELLE_LOCATION","pval":0.7553,"padj":0.9603,"ES":-0.5668,"NES":-0.75146,"nMoreExtreme":32897,"size":10,"leadingEdge":["ASPM"]} {"pathway":"GO_MESENCHYMAL_STEM_CELL_PROLIFERATION","pval":0.87503,"padj":0.97837,"ES":-0.56406,"NES":-0.75154,"nMoreExtreme":43719,"size":1,"leadingEdge":["LTBP3"]} {"pathway":"GO_LONG_CHAIN_FATTY_ACID_BIOSYNTHETIC_PROCESS","pval":0.78546,"padj":0.96311,"ES":-0.56582,"NES":-0.75167,"nMoreExtreme":31495,"size":16,"leadingEdge":["LTC4S","HPGD","ALOX15"]} {"pathway":"GO_LUNG_SECRETORY_CELL_DIFFERENTIATION","pval":0.6892,"padj":0.94995,"ES":-0.54366,"NES":-0.75174,"nMoreExtreme":31458,"size":7,"leadingEdge":["AGR2"]} {"pathway":"GO_NUCLEOTIDE_PHOSPHORYLATION","pval":0.78486,"padj":0.96311,"ES":-0.55918,"NES":-0.75205,"nMoreExtreme":30735,"size":18,"leadingEdge":["AK1","AK7"]} {"pathway":"GO_RESPONSE_TO_LEPTIN","pval":0.78478,"padj":0.96311,"ES":-0.56641,"NES":-0.75245,"nMoreExtreme":31468,"size":16,"leadingEdge":["PID1","CCNA2"]} {"pathway":"GO_REGULATION_OF_SPINDLE_ORGANIZATION","pval":0.85944,"padj":0.97645,"ES":-0.47813,"NES":-0.75263,"nMoreExtreme":27569,"size":39,"leadingEdge":["SPAG5","TPX2","PLK1","TACC3"]} {"pathway":"GO_REGULATION_OF_PROTEIN_EXIT_FROM_ENDOPLASMIC_RETICULUM","pval":0.78755,"padj":0.96334,"ES":-0.54255,"NES":-0.75339,"nMoreExtreme":29477,"size":22,"leadingEdge":["DERL3","SORL1"]} {"pathway":"GO_REGULATION_OF_DEVELOPMENT_HETEROCHRONIC","pval":0.7377,"padj":0.95793,"ES":-0.56257,"NES":-0.75357,"nMoreExtreme":32545,"size":9,"leadingEdge":["DLL1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_STRESS_FIBER_ASSEMBLY","pval":0.90569,"padj":0.98417,"ES":-0.45793,"NES":-0.75511,"nMoreExtreme":27158,"size":48,"leadingEdge":["NRP1","PXN","LIMCH1","FHOD1"]} {"pathway":"GO_RESPONSE_TO_FATTY_ACID","pval":0.98343,"padj":0.99955,"ES":-0.43003,"NES":-0.75559,"nMoreExtreme":26178,"size":65,"leadingEdge":["PID1","PDK4","GNG2","E2F1","TGFBR3","CAT","FFAR3"]} {"pathway":"GO_SIGNAL_TRANSDUCTION_INVOLVED_IN_REGULATION_OF_GENE_EXPRESSION","pval":0.76444,"padj":0.96082,"ES":-0.57405,"NES":-0.75564,"nMoreExtreme":32795,"size":11,"leadingEdge":["SOX17"]} {"pathway":"GO_REGULATION_OF_PINOCYTOSIS","pval":0.76411,"padj":0.96082,"ES":-0.57438,"NES":-0.75607,"nMoreExtreme":32781,"size":11,"leadingEdge":["APPL2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_FATTY_ACID_BETA_OXIDATION","pval":0.71467,"padj":0.9532,"ES":-0.55769,"NES":-0.75772,"nMoreExtreme":32089,"size":8,"leadingEdge":["IRS2"]} {"pathway":"GO_GENITALIA_DEVELOPMENT","pval":0.82598,"padj":0.97439,"ES":-0.49681,"NES":-0.75812,"nMoreExtreme":27765,"size":34,"leadingEdge":["MERTK","TYRO3","LGR4","CYP19A1","RBP4","BMP6","GREB1L"]} {"pathway":"GO_NUCLEOSIDE_DIPHOSPHATE_BIOSYNTHETIC_PROCESS","pval":0.71411,"padj":0.9532,"ES":-0.55878,"NES":-0.7592,"nMoreExtreme":32064,"size":8,"leadingEdge":["AK1"]} {"pathway":"GO_BONE_CELL_DEVELOPMENT","pval":0.80244,"padj":0.96646,"ES":-0.51602,"NES":-0.75945,"nMoreExtreme":28171,"size":29,"leadingEdge":["TAL1","TNFSF11","SIGLEC15"]} {"pathway":"GO_GALACTOLIPID_BIOSYNTHETIC_PROCESS","pval":0.66365,"padj":0.94905,"ES":-0.4941,"NES":-0.76054,"nMoreExtreme":33019,"size":2,"leadingEdge":["B3GALT2","B4GALT3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PHOSPHATIDYLINOSITOL_BIOSYNTHETIC_PROCESS","pval":0.58451,"padj":0.94167,"ES":-0.50562,"NES":-0.76071,"nMoreExtreme":28030,"size":4,"leadingEdge":["HTR2B"]} {"pathway":"GO_HEXOSE_PHOSPHATE_TRANSPORT","pval":0.61214,"padj":0.94703,"ES":-0.52211,"NES":-0.76088,"nMoreExtreme":28824,"size":5,"leadingEdge":["G6PC"]} {"pathway":"GO_PROTEIN_INSERTION_INTO_MITOCHONDRIAL_MEMBRANE","pval":0.86238,"padj":0.97662,"ES":-0.47313,"NES":-0.76098,"nMoreExtreme":26857,"size":43,"leadingEdge":["E2F1","TP73","BCL2"]} {"pathway":"GO_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY_INVOLVED_IN_HEART_DEVELOPMENT","pval":0.78227,"padj":0.96269,"ES":-0.53955,"NES":-0.76134,"nMoreExtreme":28685,"size":24,"leadingEdge":["SOX17","SNAI1","HEY1","BMP4","BMP2"]} {"pathway":"GO_MAMMALIAN_OOGENESIS_STAGE","pval":0.61199,"padj":0.94703,"ES":-0.52243,"NES":-0.76135,"nMoreExtreme":28817,"size":5,"leadingEdge":["PTX3"]} {"pathway":"GO_INTERLEUKIN_8_SECRETION","pval":0.78195,"padj":0.96269,"ES":-0.53965,"NES":-0.76149,"nMoreExtreme":28673,"size":24,"leadingEdge":["FCN1"]} {"pathway":"GO_ATP_BIOSYNTHETIC_PROCESS","pval":0.83198,"padj":0.97439,"ES":-0.48763,"NES":-0.76317,"nMoreExtreme":26942,"size":38,"leadingEdge":["PID1","TREM2"]} {"pathway":"GO_MESENCHYME_MORPHOGENESIS","pval":0.83759,"padj":0.97458,"ES":-0.48503,"NES":-0.7635,"nMoreExtreme":26868,"size":39,"leadingEdge":["SNAI1","HEY1","FGFR1","ENG","BMP2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CHEMOKINE_SECRETION","pval":0.76859,"padj":0.96082,"ES":-0.58106,"NES":-0.76402,"nMoreExtreme":32096,"size":13,"leadingEdge":["LPL","C5"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY","pval":0.82595,"padj":0.97439,"ES":-0.49092,"NES":-0.76432,"nMoreExtreme":27034,"size":37,"leadingEdge":["NECAB2","DNM1","STMN1","HTR2B"]} {"pathway":"GO_REGULATION_OF_CARTILAGE_DEVELOPMENT","pval":0.93085,"padj":0.98762,"ES":-0.44679,"NES":-0.76452,"nMoreExtreme":26301,"size":57,"leadingEdge":["MAF","RFLNB","RUNX2","BMP6","BMP4","BMP2"]} {"pathway":"GO_IRE1_MEDIATED_UNFOLDED_PROTEIN_RESPONSE","pval":0.95348,"padj":0.9929,"ES":-0.43972,"NES":-0.76487,"nMoreExtreme":25904,"size":62,"leadingEdge":["AGR2","LMNA","EXTL1","PLA2G4B","DDX11"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_PERMEABILITY","pval":0.58794,"padj":0.94167,"ES":-0.49683,"NES":-0.76675,"nMoreExtreme":28738,"size":3,"leadingEdge":["BNIP3","ACAA2","HK2"]} {"pathway":"GO_GENETIC_IMPRINTING","pval":0.76997,"padj":0.96082,"ES":-0.55217,"NES":-0.76676,"nMoreExtreme":28819,"size":22,"leadingEdge":["BRCA1"]} {"pathway":"GO_SIGNAL_COMPLEX_ASSEMBLY","pval":0.68286,"padj":0.94976,"ES":-0.55618,"NES":-0.76904,"nMoreExtreme":31169,"size":7,"leadingEdge":["PXN"]} {"pathway":"GO_INTESTINAL_ABSORPTION","pval":0.76688,"padj":0.96082,"ES":-0.56349,"NES":-0.76922,"nMoreExtreme":29284,"size":20,"leadingEdge":["SLC2A5","SLC46A1"]} {"pathway":"GO_PRESYNAPTIC_ENDOCYTOSIS","pval":0.87111,"padj":0.97717,"ES":-0.46693,"NES":-0.76995,"nMoreExtreme":26121,"size":48,"leadingEdge":["SYT1","DNM1","ITSN1"]} {"pathway":"GO_AXIS_SPECIFICATION","pval":0.92757,"padj":0.987,"ES":-0.44651,"NES":-0.77159,"nMoreExtreme":25522,"size":60,"leadingEdge":["DLL1","MNS1","WLS","IFT172","PCSK6","SKI","STIL","BMP4"]} {"pathway":"GO_MIDBRAIN_DEVELOPMENT","pval":0.97842,"padj":0.99901,"ES":-0.43015,"NES":-0.77163,"nMoreExtreme":24661,"size":73,"leadingEdge":["INA","FZD3","GDF7","WLS","FGFR1","KAT2A","CCDC14","NDRG2"]} {"pathway":"GO_PYRIMIDINE_NUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS","pval":0.76271,"padj":0.96082,"ES":-0.58253,"NES":-0.77386,"nMoreExtreme":30583,"size":16,"leadingEdge":["TYMS"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY","pval":0.77837,"padj":0.96098,"ES":-0.52586,"NES":-0.77393,"nMoreExtreme":27326,"size":29,"leadingEdge":["CDKN2C","PLK1","CDKN2B","TFAP4"]} {"pathway":"GO_PROTEIN_EXIT_FROM_ENDOPLASMIC_RETICULUM","pval":0.81801,"padj":0.97133,"ES":-0.48908,"NES":-0.77454,"nMoreExtreme":26042,"size":40,"leadingEdge":["DERL3","SORL1"]} {"pathway":"GO_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS","pval":0.79084,"padj":0.96486,"ES":-0.51127,"NES":-0.77501,"nMoreExtreme":26807,"size":33,"leadingEdge":["PDK4","SLC45A3","BRCA1"]} {"pathway":"GO_RESPONSE_TO_PH","pval":0.76526,"padj":0.96082,"ES":-0.54011,"NES":-0.77531,"nMoreExtreme":27563,"size":26,"leadingEdge":["PKD1L3","ASIC1"]} {"pathway":"GO_ATRIAL_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT","pval":0.60662,"padj":0.94703,"ES":-0.53222,"NES":-0.77562,"nMoreExtreme":28564,"size":5,"leadingEdge":["ENG"]} {"pathway":"GO_DETECTION_OF_MECHANICAL_STIMULUS","pval":0.77118,"padj":0.96084,"ES":-0.5309,"NES":-0.77566,"nMoreExtreme":27302,"size":28,"leadingEdge":["PKD1L3","BACE1"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_NITRIC_OXIDE","pval":0.75884,"padj":0.9603,"ES":-0.59042,"NES":-0.77633,"nMoreExtreme":31689,"size":13,"leadingEdge":["CCNA2","CDK2"]} {"pathway":"GO_REGULATION_OF_VITAMIN_D_RECEPTOR_SIGNALING_PATHWAY","pval":0.64526,"padj":0.94878,"ES":-0.54831,"NES":-0.77644,"nMoreExtreme":29895,"size":6,"leadingEdge":["KANK2"]} {"pathway":"GO_GLYCOSYL_COMPOUND_BIOSYNTHETIC_PROCESS","pval":0.80163,"padj":0.96646,"ES":-0.49876,"NES":-0.77652,"nMoreExtreme":26238,"size":37,"leadingEdge":["TK1","PRTFDC1"]} {"pathway":"GO_CDP_DIACYLGLYCEROL_BIOSYNTHETIC_PROCESS","pval":0.75597,"padj":0.9603,"ES":-0.59057,"NES":-0.7766,"nMoreExtreme":31991,"size":12,"leadingEdge":["LCLAT1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ENDOCYTOSIS","pval":0.80099,"padj":0.96646,"ES":-0.49894,"NES":-0.77681,"nMoreExtreme":26217,"size":37,"leadingEdge":["NECAB2","LRRTM1","SCAMP5","PROM2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_AXONOGENESIS","pval":0.97076,"padj":0.99701,"ES":-0.43266,"NES":-0.77785,"nMoreExtreme":24302,"size":74,"leadingEdge":["NRP1","PLXNA2","TIAM1"]} {"pathway":"GO_CELLULAR_IRON_ION_HOMEOSTASIS","pval":0.8691,"padj":0.97662,"ES":-0.4641,"NES":-0.77785,"nMoreExtreme":25382,"size":52,"leadingEdge":["ABCG2","SLC11A1","SLC40A1","SLC46A1"]} {"pathway":"GO_RESPONSE_TO_ACIDIC_PH","pval":0.7574,"padj":0.9603,"ES":-0.58654,"NES":-0.77919,"nMoreExtreme":30370,"size":16,"leadingEdge":["PKD1L3","ASIC1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL","pval":0.75709,"padj":0.9603,"ES":-0.59001,"NES":-0.77965,"nMoreExtreme":30721,"size":15,"leadingEdge":["TRDN","BCL2","NTSR1","GSTM2"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_REACTIVE_NITROGEN_SPECIES","pval":0.75655,"padj":0.9603,"ES":-0.59041,"NES":-0.78018,"nMoreExtreme":30699,"size":15,"leadingEdge":["CCNA2","CDK2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_RYANODINE_SENSITIVE_CALCIUM_RELEASE_CHANNEL_ACTIVITY","pval":0.73905,"padj":0.95841,"ES":-0.58896,"NES":-0.78085,"nMoreExtreme":32189,"size":10,"leadingEdge":["TRDN"]} {"pathway":"GO_REGULATION_OF_COFACTOR_METABOLIC_PROCESS","pval":0.76646,"padj":0.96082,"ES":-0.53076,"NES":-0.78114,"nMoreExtreme":26908,"size":29,"leadingEdge":["PDK4","MPV17L"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_MATURATION","pval":0.75241,"padj":0.9603,"ES":-0.57661,"NES":-0.7812,"nMoreExtreme":29030,"size":19,"leadingEdge":["ADAM8","MELTF","CLEC3B"]} {"pathway":"GO_REGULATION_OF_THYMOCYTE_APOPTOTIC_PROCESS","pval":0.75429,"padj":0.9603,"ES":-0.59443,"NES":-0.78161,"nMoreExtreme":31499,"size":13,"leadingEdge":["ADAM8","BLM","BMP4"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_BONE_DEVELOPMENT","pval":0.64338,"padj":0.94878,"ES":-0.55223,"NES":-0.78198,"nMoreExtreme":29808,"size":6,"leadingEdge":["RFLNB"]} {"pathway":"GO_LUNG_EPITHELIUM_DEVELOPMENT","pval":0.75842,"padj":0.9603,"ES":-0.53577,"NES":-0.78278,"nMoreExtreme":26850,"size":28,"leadingEdge":["AGR2","RCN3","BMP4","THRB"]} {"pathway":"GO_FOLIC_ACID_METABOLIC_PROCESS","pval":0.75162,"padj":0.9603,"ES":-0.58566,"NES":-0.78282,"nMoreExtreme":29742,"size":17,"leadingEdge":["DHFR","SLC46A1","SHMT1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION","pval":0.75006,"padj":0.9603,"ES":-0.58214,"NES":-0.78292,"nMoreExtreme":29372,"size":18,"leadingEdge":["DAB1","DLX1"]} {"pathway":"GO_REGULATION_OF_POLYSACCHARIDE_METABOLIC_PROCESS","pval":0.78457,"padj":0.96311,"ES":-0.50635,"NES":-0.78333,"nMoreExtreme":25900,"size":36,"leadingEdge":["INSR","KHK","PASK","IRS2","PPP1R3G"]} {"pathway":"GO_PINOCYTOSIS","pval":0.74884,"padj":0.9603,"ES":-0.57437,"NES":-0.78406,"nMoreExtreme":28595,"size":20,"leadingEdge":["APPL2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SYNAPTIC_PLASTICITY","pval":0.70364,"padj":0.9504,"ES":-0.57738,"NES":-0.78448,"nMoreExtreme":31594,"size":8,"leadingEdge":["CDC20"]} {"pathway":"GO_REGULATION_OF_FATTY_ACID_OXIDATION","pval":0.7489,"padj":0.9603,"ES":-0.55659,"NES":-0.78538,"nMoreExtreme":27461,"size":24,"leadingEdge":["PDK4","APPL2"]} {"pathway":"GO_REGULATION_OF_EXIT_FROM_MITOSIS","pval":0.74746,"padj":0.96029,"ES":-0.5799,"NES":-0.78565,"nMoreExtreme":28839,"size":19,"leadingEdge":["CDCA5","ANLN","UBE2C"]} {"pathway":"GO_PEPTIDYL_TYROSINE_DEPHOSPHORYLATION","pval":0.9864,"padj":0.99994,"ES":-0.42512,"NES":-0.78592,"nMoreExtreme":22839,"size":87,"leadingEdge":["CDC25A","CDC25C","PTPN14","CDKN3","PTPN13","PALD1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_BEHAVIOR","pval":0.74893,"padj":0.9603,"ES":-0.59783,"NES":-0.78615,"nMoreExtreme":31693,"size":12,"leadingEdge":["GHRL"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CATECHOLAMINE_SECRETION","pval":0.67561,"padj":0.94976,"ES":-0.56925,"NES":-0.78712,"nMoreExtreme":30838,"size":7,"leadingEdge":["STX1A"]} {"pathway":"GO_SOMATOTROPIN_SECRETING_CELL_DIFFERENTIATION","pval":0.63379,"padj":0.94878,"ES":-0.51146,"NES":-0.78726,"nMoreExtreme":31533,"size":2,"leadingEdge":["PITX2","WNT4"]} {"pathway":"GO_SUBSTRATE_DEPENDENT_CELL_MIGRATION_CELL_EXTENSION","pval":0.73526,"padj":0.95787,"ES":-0.59392,"NES":-0.78743,"nMoreExtreme":32024,"size":10,"leadingEdge":["NRP1"]} {"pathway":"GO_SEGMENTATION","pval":0.96459,"padj":0.99537,"ES":-0.43331,"NES":-0.78815,"nMoreExtreme":23429,"size":79,"leadingEdge":["NRP1","PLXNA2","XRCC2","DLL1","IRX3","PCSK6","KAT2A","BMP4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_DNA_REPAIR","pval":0.8976,"padj":0.98354,"ES":-0.45197,"NES":-0.78859,"nMoreExtreme":24201,"size":63,"leadingEdge":["BRCA1","FANCB","FOXM1","BLM","SLF1","DDX11","PCNA"]} {"pathway":"GO_BLASTOCYST_FORMATION","pval":0.76048,"padj":0.96082,"ES":-0.52386,"NES":-0.78895,"nMoreExtreme":26037,"size":32,"leadingEdge":["SOX17"]} {"pathway":"GO_POSITIVE_REGULATION_OF_FOCAL_ADHESION_ASSEMBLY","pval":0.74086,"padj":0.95908,"ES":-0.56463,"NES":-0.79027,"nMoreExtreme":27473,"size":23,"leadingEdge":["NRP1"]} {"pathway":"GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MITOCHONDRION","pval":0.90627,"padj":0.98417,"ES":-0.44872,"NES":-0.79034,"nMoreExtreme":23950,"size":66,"leadingEdge":["ABLIM3","E2F1","TP73","BCL2"]} {"pathway":"GO_HIPPOCAMPUS_DEVELOPMENT","pval":0.89492,"padj":0.98309,"ES":-0.4518,"NES":-0.7909,"nMoreExtreme":23956,"size":64,"leadingEdge":["DAB1","KIF14","DLX1","CDK5R1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING","pval":0.75103,"padj":0.9603,"ES":-0.5333,"NES":-0.79106,"nMoreExtreme":26144,"size":30,"leadingEdge":["NRP1"]} {"pathway":"GO_ENERGY_HOMEOSTASIS","pval":0.74421,"padj":0.95959,"ES":-0.54167,"NES":-0.7914,"nMoreExtreme":26347,"size":28,"leadingEdge":["DLL1","PASK","IRX3","BMP8A"]} {"pathway":"GO_INTERMEDIATE_FILAMENT_BASED_PROCESS","pval":0.75592,"padj":0.9603,"ES":-0.52557,"NES":-0.79152,"nMoreExtreme":25881,"size":32,"leadingEdge":["INA","NES"]} {"pathway":"GO_MYOTUBE_CELL_DEVELOPMENT","pval":0.73745,"padj":0.95787,"ES":-0.55707,"NES":-0.79317,"nMoreExtreme":26767,"size":25,"leadingEdge":["BCL2","DNER","SMYD3","RYR1","SKI","WNT10B"]} {"pathway":"GO_REGULATION_OF_TELOMERASE_ACTIVITY","pval":0.80137,"padj":0.96646,"ES":-0.48846,"NES":-0.79362,"nMoreExtreme":24501,"size":45,"leadingEdge":["PKIB","AURKB","NEK2","PARM1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_RESPIRATORY_BURST","pval":0.56286,"padj":0.93517,"ES":-0.51452,"NES":-0.79406,"nMoreExtreme":27512,"size":3,"leadingEdge":["INSR"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_CYTOSKELETON","pval":0.83346,"padj":0.97443,"ES":-0.47184,"NES":-0.79426,"nMoreExtreme":24166,"size":53,"leadingEdge":["ANLN","TTK","SPAG5","FAM83D","CCDC14","CEP72","STIL","KIF20B"]} {"pathway":"GO_REGULATION_OF_BEHAVIOR","pval":0.76003,"padj":0.96073,"ES":-0.517,"NES":-0.79436,"nMoreExtreme":25346,"size":35,"leadingEdge":["GHRL","HTR2B","RETN"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING","pval":0.76918,"padj":0.96082,"ES":-0.50774,"NES":-0.79465,"nMoreExtreme":24908,"size":38,"leadingEdge":["TRDN","AKAP6","TREM2","GSTM2"]} {"pathway":"GO_REGULATION_OF_GTP_BINDING","pval":0.74196,"padj":0.95912,"ES":-0.60443,"NES":-0.79482,"nMoreExtreme":31398,"size":12,"leadingEdge":["STMN1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION","pval":0.95877,"padj":0.9934,"ES":-0.43304,"NES":-0.79749,"nMoreExtreme":22464,"size":85,"leadingEdge":["NRP1","SEMA6B","FSTL4","DAB1","MELTF","SEMA3G","SEMA6C","CDK5R1","SEMA4C","NGEF"]} {"pathway":"GO_RESPONSE_TO_GRAVITY","pval":0.63809,"padj":0.94878,"ES":-0.56357,"NES":-0.79805,"nMoreExtreme":29563,"size":6,"leadingEdge":["STX1A","FOS"]} {"pathway":"GO_REGULATION_OF_SPROUTING_ANGIOGENESIS","pval":0.86923,"padj":0.97662,"ES":-0.45745,"NES":-0.79815,"nMoreExtreme":23436,"size":63,"leadingEdge":["E2F2","NRP1","GHRL","DLL1","SRPX2","MMRN2","THBS1"]} {"pathway":"GO_SYNAPTIC_VESICLE_RECYCLING","pval":0.84056,"padj":0.97458,"ES":-0.46692,"NES":-0.79897,"nMoreExtreme":23750,"size":57,"leadingEdge":["SYT1","DNM1","ITSN1"]} {"pathway":"GO_DORSAL_AORTA_DEVELOPMENT","pval":0.69681,"padj":0.94995,"ES":-0.5895,"NES":-0.80095,"nMoreExtreme":31287,"size":8,"leadingEdge":["HEY1","ENG"]} {"pathway":"GO_DENDRITIC_SPINE_DEVELOPMENT","pval":0.95573,"padj":0.9934,"ES":-0.43346,"NES":-0.80133,"nMoreExtreme":22129,"size":87,"leadingEdge":["EPHB3","FSTL4","TIAM1","CDK5R1","ITPKA","CUX2","CAMK1","NGEF"]} {"pathway":"GO_REGULATION_OF_MEIOTIC_NUCLEAR_DIVISION","pval":0.72641,"padj":0.95562,"ES":-0.58224,"NES":-0.80177,"nMoreExtreme":27432,"size":21,"leadingEdge":["PDE3A","TTK","FBXO5","CDC20","TRIP13","FBXO43","GPR3"]} {"pathway":"GO_NUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS","pval":0.72617,"padj":0.95562,"ES":-0.55916,"NES":-0.80266,"nMoreExtreme":26155,"size":26,"leadingEdge":["AK1","AK7"]} {"pathway":"GO_MATURE_B_CELL_DIFFERENTIATION","pval":0.7249,"padj":0.95562,"ES":-0.58318,"NES":-0.80306,"nMoreExtreme":27375,"size":21,"leadingEdge":["GPR183","DLL1"]} {"pathway":"GO_FATTY_ACID_CATABOLIC_PROCESS","pval":0.96399,"padj":0.99503,"ES":-0.43117,"NES":-0.80339,"nMoreExtreme":21870,"size":91,"leadingEdge":["HADH","ADTRP","ACOX2","IRS2"]} {"pathway":"GO_ADHERENS_JUNCTION_ASSEMBLY","pval":0.94255,"padj":0.98878,"ES":-0.43628,"NES":-0.80346,"nMoreExtreme":22084,"size":85,"leadingEdge":["NRP1","LIMCH1","BCL2","ARHGAP6","THBS1"]} {"pathway":"GO_REGULATION_OF_CARDIAC_MUSCLE_ADAPTATION","pval":0.63598,"padj":0.94878,"ES":-0.56743,"NES":-0.80352,"nMoreExtreme":29465,"size":6,"leadingEdge":["LMNA"]} {"pathway":"GO_PONS_DEVELOPMENT","pval":0.63572,"padj":0.94878,"ES":-0.56783,"NES":-0.80408,"nMoreExtreme":29453,"size":6,"leadingEdge":["BCL2","CDK5R1"]} {"pathway":"GO_PYRIMIDINE_CONTAINING_COMPOUND_METABOLIC_PROCESS","pval":0.72457,"padj":0.95562,"ES":-0.58904,"NES":-0.80409,"nMoreExtreme":27668,"size":20,"leadingEdge":["TYMS","TK1","RRM1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION","pval":0.75439,"padj":0.9603,"ES":-0.51093,"NES":-0.80427,"nMoreExtreme":24199,"size":39,"leadingEdge":["CX3CR1","ADGRG1","FZD3","ASPM","FZD9","CIP2A","NES"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION","pval":0.73206,"padj":0.95661,"ES":-0.60559,"NES":-0.80449,"nMoreExtreme":29354,"size":16,"leadingEdge":["APPL2"]} {"pathway":"GO_INTRA_GOLGI_VESICLE_MEDIATED_TRANSPORT","pval":0.72728,"padj":0.95577,"ES":-0.54257,"NES":-0.80482,"nMoreExtreme":25317,"size":30,"leadingEdge":["RAB6B"]} {"pathway":"GO_ENDOTHELIAL_CELL_MATRIX_ADHESION","pval":0.55291,"padj":0.93341,"ES":-0.52199,"NES":-0.80559,"nMoreExtreme":27026,"size":3,"leadingEdge":["MMP12","PECAM1","ADAMTS9"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ACTIN_CYTOSKELETON_REORGANIZATION","pval":0.72662,"padj":0.95562,"ES":-0.60333,"NES":-0.80645,"nMoreExtreme":28753,"size":17,"leadingEdge":["NRP1","BAIAP2"]} {"pathway":"GO_SYNAPTIC_TRANSMISSION_DOPAMINERGIC","pval":0.73014,"padj":0.95629,"ES":-0.60708,"NES":-0.80648,"nMoreExtreme":29277,"size":16,"leadingEdge":["CRHBP","PRKN"]} {"pathway":"GO_REGULATION_OF_RECEPTOR_BINDING","pval":0.72043,"padj":0.95459,"ES":-0.59677,"NES":-0.8085,"nMoreExtreme":27796,"size":19,"leadingEdge":["NRP1","MMP9"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_NEURON_MIGRATION","pval":0.72305,"padj":0.95562,"ES":-0.61018,"NES":-0.80898,"nMoreExtreme":31492,"size":10,"leadingEdge":["ADGRG1","NEXMIF"]} {"pathway":"GO_CARDIAC_CELL_DEVELOPMENT","pval":0.84722,"padj":0.97561,"ES":-0.46046,"NES":-0.80905,"nMoreExtreme":22552,"size":65,"leadingEdge":["CDK1","CXADR","MYOM1","PARP2","AKAP6","SGCD","TGFBR3","LMNA","BMP4","MYOM3","NRAP"]} {"pathway":"GO_SENSORY_PERCEPTION_OF_TASTE","pval":0.72013,"padj":0.95459,"ES":-0.60214,"NES":-0.80982,"nMoreExtreme":28200,"size":18,"leadingEdge":["PKD1L3","ASIC1"]} {"pathway":"GO_ACID_SECRETION","pval":0.90471,"padj":0.98417,"ES":-0.4447,"NES":-0.81047,"nMoreExtreme":21817,"size":80,"leadingEdge":["TNFRSF11A","SYT1","GHRL","HRH2","STX1A","ABCC4","TNFSF11","MAP2K6","ACE","PPFIA2","ABCC3","NTSR1","SLC9A3R1","APBA1"]} {"pathway":"GO_SULFATE_TRANSPORT","pval":0.72197,"padj":0.95512,"ES":-0.61134,"NES":-0.81052,"nMoreExtreme":31445,"size":10,"leadingEdge":["SLC25A10","SLC26A9","RACGAP1"]} {"pathway":"GO_CELLULAR_METABOLIC_COMPOUND_SALVAGE","pval":0.71585,"padj":0.95355,"ES":-0.54751,"NES":-0.81215,"nMoreExtreme":24919,"size":30,"leadingEdge":["TK1","PRTFDC1"]} {"pathway":"GO_WATER_SOLUBLE_VITAMIN_METABOLIC_PROCESS","pval":0.86143,"padj":0.97645,"ES":-0.45621,"NES":-0.81225,"nMoreExtreme":22173,"size":70,"leadingEdge":["DHFR","PC","VNN1","SLC46A1","SHMT1"]} {"pathway":"GO_REGULATION_OF_ENAMEL_MINERALIZATION","pval":0.78354,"padj":0.96311,"ES":-0.60983,"NES":-0.81253,"nMoreExtreme":39148,"size":1,"leadingEdge":["ODAPH"]} {"pathway":"GO_CERAMIDE_METABOLIC_PROCESS","pval":0.71317,"padj":0.9532,"ES":-0.59574,"NES":-0.81324,"nMoreExtreme":27233,"size":20,"leadingEdge":["SGPL1"]} {"pathway":"GO_CELLULAR_AMINO_ACID_BIOSYNTHETIC_PROCESS","pval":0.78614,"padj":0.96311,"ES":-0.48323,"NES":-0.81343,"nMoreExtreme":22794,"size":53,"leadingEdge":["SERINC5","SHMT1","RIMKLA","NAT8L"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION","pval":0.75013,"padj":0.9603,"ES":-0.50578,"NES":-0.81349,"nMoreExtreme":23361,"size":43,"leadingEdge":["CDC45","CDC6","FAM83D","CCNE1","LSM11"]} {"pathway":"GO_REGULATION_OF_BONE_REMODELING","pval":0.72486,"padj":0.95562,"ES":-0.52967,"NES":-0.81383,"nMoreExtreme":24173,"size":35,"leadingEdge":["S1PR1","PDK4","TNFRSF11A","ADAM8","PRKCA","TNFSF11"]} {"pathway":"GO_REGULATION_OF_ESTABLISHMENT_OR_MAINTENANCE_OF_CELL_POLARITY","pval":0.70971,"padj":0.95201,"ES":-0.57697,"NES":-0.81415,"nMoreExtreme":26024,"size":24,"leadingEdge":["CDH5","KIF20B"]} {"pathway":"GO_MONOCARBOXYLIC_ACID_CATABOLIC_PROCESS","pval":0.95822,"padj":0.9934,"ES":-0.43114,"NES":-0.81481,"nMoreExtreme":20434,"size":100,"leadingEdge":["HADH","ADTRP","ACOX2","IRS2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_BONE_MINERALIZATION","pval":0.72822,"padj":0.95596,"ES":-0.61995,"NES":-0.81516,"nMoreExtreme":30410,"size":13,"leadingEdge":["RFLNB"]} {"pathway":"GO_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY","pval":0.91555,"padj":0.987,"ES":-0.44037,"NES":-0.81606,"nMoreExtreme":21139,"size":88,"leadingEdge":["SHCBP1","KL","FLRT3","RUNX2","FGFR1","THBS1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MEIOTIC_NUCLEAR_DIVISION","pval":0.69057,"padj":0.94995,"ES":-0.60112,"NES":-0.81673,"nMoreExtreme":31007,"size":8,"leadingEdge":["TTK","FBXO5","TRIP13","FBXO43"]} {"pathway":"GO_REGULATION_OF_ENDOTHELIAL_CELL_DEVELOPMENT","pval":0.71848,"padj":0.95459,"ES":-0.61637,"NES":-0.81719,"nMoreExtreme":31293,"size":10,"leadingEdge":["CDH5"]} {"pathway":"GO_RIBONUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS","pval":0.77327,"padj":0.96098,"ES":-0.4876,"NES":-0.81723,"nMoreExtreme":22583,"size":52,"leadingEdge":["PID1","TREM2"]} {"pathway":"GO_REGULATION_OF_NODAL_SIGNALING_PATHWAY","pval":0.77568,"padj":0.96098,"ES":-0.61376,"NES":-0.81777,"nMoreExtreme":38755,"size":1,"leadingEdge":["SMAD2"]} {"pathway":"GO_REGULATION_OF_NODAL_SIGNALING_PATHWAY_INVOLVED_IN_DETERMINATION_OF_LEFT_RIGHT_ASYMMETRY","pval":0.77568,"padj":0.96098,"ES":-0.61376,"NES":-0.81777,"nMoreExtreme":38755,"size":1,"leadingEdge":["SMAD2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MEMBRANE_REPOLARIZATION_DURING_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL","pval":0.77396,"padj":0.96098,"ES":-0.6146,"NES":-0.81889,"nMoreExtreme":38669,"size":1,"leadingEdge":["KCNE3"]} {"pathway":"GO_REGULATION_OF_MEMBRANE_PERMEABILITY","pval":0.84497,"padj":0.97458,"ES":-0.45756,"NES":-0.81896,"nMoreExtreme":21441,"size":72,"leadingEdge":["E2F1","TP73","BCL2","FZD9","MPV17L"]} {"pathway":"GO_POSITIVE_REGULATION_OF_REPRODUCTIVE_PROCESS","pval":0.75946,"padj":0.96041,"ES":-0.49285,"NES":-0.82002,"nMoreExtreme":22526,"size":50,"leadingEdge":["CDC25A","PLB1","PDE3A","CDC25C","INSR"]} {"pathway":"GO_ERYTHROCYTE_DEVELOPMENT","pval":0.70165,"padj":0.94995,"ES":-0.58601,"NES":-0.8202,"nMoreExtreme":26019,"size":23,"leadingEdge":["TAL1"]} {"pathway":"GO_OOGENESIS","pval":0.77902,"padj":0.96098,"ES":-0.48187,"NES":-0.82148,"nMoreExtreme":22170,"size":56,"leadingEdge":["PAQR5","DMC1","PDE3A","ASPM","FBXO5","BCL2","TRIP13"]} {"pathway":"GO_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH","pval":0.76275,"padj":0.96082,"ES":-0.49032,"NES":-0.8218,"nMoreExtreme":22276,"size":52,"leadingEdge":["GHRL","SGPL1","GAMT","BCL2","ADRB1"]} {"pathway":"GO_DENDRITE_MORPHOGENESIS","pval":0.99174,"padj":1,"ES":-0.42103,"NES":-0.82276,"nMoreExtreme":18379,"size":125,"leadingEdge":["EPHB3","NRP1","SDC2","TIAM1","CDK5R1","ITPKA","CUX2","CELSR2","NGEF"]} {"pathway":"GO_DEOXYRIBOSE_PHOSPHATE_BIOSYNTHETIC_PROCESS","pval":0.72105,"padj":0.95459,"ES":-0.62608,"NES":-0.8233,"nMoreExtreme":30513,"size":12,"leadingEdge":["TYMS","SHMT1","DUT"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY","pval":0.69947,"padj":0.94995,"ES":-0.54756,"NES":-0.82464,"nMoreExtreme":23948,"size":32,"leadingEdge":["CDC6","CDK5R1"]} {"pathway":"GO_DEOXYRIBONUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS","pval":0.62954,"padj":0.94878,"ES":-0.58253,"NES":-0.8249,"nMoreExtreme":29167,"size":6,"leadingEdge":["TYMS"]} {"pathway":"GO_DECIDUALIZATION","pval":0.69948,"padj":0.94995,"ES":-0.60476,"NES":-0.82555,"nMoreExtreme":26710,"size":20,"leadingEdge":["GHRL"]} {"pathway":"GO_REGULATION_OF_INWARD_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY","pval":0.54969,"padj":0.93134,"ES":-0.54878,"NES":-0.82564,"nMoreExtreme":26360,"size":4,"leadingEdge":["TREM2"]} {"pathway":"GO_PROPRIOCEPTION","pval":0.59552,"padj":0.94465,"ES":-0.53651,"NES":-0.82582,"nMoreExtreme":29629,"size":2,"leadingEdge":["MECP2","FXN"]} {"pathway":"GO_REGULATION_OF_BONE_MINERALIZATION","pval":0.77749,"padj":0.96098,"ES":-0.47959,"NES":-0.82628,"nMoreExtreme":21586,"size":59,"leadingEdge":["S1PR1","TMEM119","ANKH","RFLNB","KL","FZD9"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_ADAPTATION","pval":0.58852,"padj":0.94167,"ES":-0.56743,"NES":-0.82694,"nMoreExtreme":27712,"size":5,"leadingEdge":["LMNA"]} {"pathway":"GO_TRIGEMINAL_NERVE_DEVELOPMENT","pval":0.68547,"padj":0.94976,"ES":-0.60966,"NES":-0.82833,"nMoreExtreme":30778,"size":8,"leadingEdge":["NRP1"]} {"pathway":"GO_DETERMINATION_OF_HEART_LEFT_RIGHT_ASYMMETRY","pval":0.72386,"padj":0.95562,"ES":-0.51019,"NES":-0.82893,"nMoreExtreme":22131,"size":45,"leadingEdge":["MICAL2","SOX17","DLL1","IFT172","STIL","ENG"]} {"pathway":"GO_G_PROTEIN_COUPLED_ACETYLCHOLINE_RECEPTOR_SIGNALING_PATHWAY","pval":0.71663,"padj":0.95386,"ES":-0.63079,"NES":-0.82949,"nMoreExtreme":30326,"size":12,"leadingEdge":["CDK5R1","CHRM3","RGS10"]} {"pathway":"GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE","pval":0.85755,"padj":0.97645,"ES":-0.45217,"NES":-0.82954,"nMoreExtreme":20347,"size":83,"leadingEdge":["PID1","AGR2","DAB2","TREM2","ARHGEF16"]} {"pathway":"GO_NUCLEUS_LOCALIZATION","pval":0.68907,"padj":0.94995,"ES":-0.59753,"NES":-0.82975,"nMoreExtreme":25791,"size":22,"leadingEdge":["FHOD1","KIF25","SLC9A3R1","SYNE3"]} {"pathway":"GO_CELL_CELL_JUNCTION_ORGANIZATION","pval":0.97563,"padj":0.99825,"ES":-0.4254,"NES":-0.83062,"nMoreExtreme":18214,"size":124,"leadingEdge":["CDH5","CXADR","FSCN1","PRKCA","GJC1","CD9","ACE","NECTIN1","CDH26","SNAI1","MARVELD3","GJA5","MPP7","CDH12","PATJ","NLGN2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION","pval":0.68551,"padj":0.94976,"ES":-0.56463,"NES":-0.83099,"nMoreExtreme":24066,"size":29,"leadingEdge":["NRP1"]} {"pathway":"GO_MITOTIC_NUCLEAR_ENVELOPE_REASSEMBLY","pval":0.70982,"padj":0.95201,"ES":-0.62685,"NES":-0.83108,"nMoreExtreme":30916,"size":10,"leadingEdge":["LMNA"]} {"pathway":"GO_SPINAL_CORD_MOTOR_NEURON_DIFFERENTIATION","pval":0.69267,"padj":0.94995,"ES":-0.60904,"NES":-0.8314,"nMoreExtreme":26450,"size":20,"leadingEdge":["OLIG2","IFT172","NKX6-2"]} {"pathway":"GO_DNA_REPLICATION_SYNTHESIS_OF_RNA_PRIMER","pval":0.58714,"padj":0.94167,"ES":-0.57061,"NES":-0.83157,"nMoreExtreme":27647,"size":5,"leadingEdge":["POLA1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CARDIOCYTE_DIFFERENTIATION","pval":0.70009,"padj":0.94995,"ES":-0.62228,"NES":-0.83176,"nMoreExtreme":27703,"size":17,"leadingEdge":["DLL1","FZD7","BMP2","RGS4"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_ENDOSOME","pval":0.68497,"padj":0.94976,"ES":-0.58972,"NES":-0.83214,"nMoreExtreme":25117,"size":24,"leadingEdge":["NRP1","SORL1","LRRC7"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_LONG_TERM_SYNAPTIC_POTENTIATION","pval":0.71521,"padj":0.95345,"ES":-0.63218,"NES":-0.83215,"nMoreExtreme":30683,"size":11,"leadingEdge":["CX3CR1"]} {"pathway":"GO_MULTICELLULAR_ORGANISM_GROWTH","pval":0.96629,"padj":0.99537,"ES":-0.42728,"NES":-0.83232,"nMoreExtreme":18231,"size":122,"leadingEdge":["G6PC","GHRL","XRCC2","SGPL1","GAMT","BCL2","ADRB1","KAT2A","APBA1","STIL"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_EARLY_ENDOSOME","pval":0.71423,"padj":0.9532,"ES":-0.63359,"NES":-0.83401,"nMoreExtreme":30641,"size":11,"leadingEdge":["NRP1","SORL1","LRRC7"]} {"pathway":"GO_ASTROCYTE_DIFFERENTIATION","pval":0.77124,"padj":0.96084,"ES":-0.47804,"NES":-0.83407,"nMoreExtreme":20794,"size":63,"leadingEdge":["TAL1","DAB1","DLL1","TREM2","C5AR1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SUPRAMOLECULAR_FIBER_ORGANIZATION","pval":0.92616,"padj":0.987,"ES":-0.43414,"NES":-0.83489,"nMoreExtreme":18449,"size":112,"leadingEdge":["S1PR1","STMN1","ARHGAP6","LMOD1","PRKN"]} {"pathway":"GO_D_AMINO_ACID_TRANSPORT","pval":0.62687,"padj":0.94878,"ES":-0.58965,"NES":-0.83499,"nMoreExtreme":29043,"size":6,"leadingEdge":["NTSR1"]} {"pathway":"GO_REGULATION_OF_EARLY_ENDOSOME_TO_LATE_ENDOSOME_TRANSPORT","pval":0.69559,"padj":0.94995,"ES":-0.62543,"NES":-0.83597,"nMoreExtreme":27525,"size":17,"leadingEdge":["DAB2"]} {"pathway":"GO_CARDIAC_MYOFIBRIL_ASSEMBLY","pval":0.68972,"padj":0.94995,"ES":-0.61711,"NES":-0.83607,"nMoreExtreme":26611,"size":19,"leadingEdge":["MYOM1","MYOM3","NRAP"]} {"pathway":"GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS_ENDONUCLEOLYTIC","pval":0.77456,"padj":0.96098,"ES":-0.47494,"NES":-0.83652,"nMoreExtreme":20469,"size":66,"leadingEdge":["EXO1","FEN1"]} {"pathway":"GO_FUNGIFORM_PAPILLA_DEVELOPMENT","pval":0.62648,"padj":0.94878,"ES":-0.59082,"NES":-0.83663,"nMoreExtreme":29025,"size":6,"leadingEdge":["WNT10B"]} {"pathway":"GO_MEGAKARYOCYTE_DIFFERENTIATION","pval":0.75105,"padj":0.9603,"ES":-0.48566,"NES":-0.83673,"nMoreExtreme":20852,"size":59,"leadingEdge":["TESC","TAL1","HMGB2","CDKN2B","THBS1"]} {"pathway":"GO_EMBRYONIC_HEMOPOIESIS","pval":0.69501,"padj":0.94995,"ES":-0.62604,"NES":-0.83679,"nMoreExtreme":27502,"size":17,"leadingEdge":["KITLG","TAL1"]} {"pathway":"GO_RESPONSE_TO_LEAD_ION","pval":0.6873,"padj":0.94995,"ES":-0.61312,"NES":-0.83697,"nMoreExtreme":26245,"size":20,"leadingEdge":["BACE1","CAT"]} {"pathway":"GO_REGULATION_OF_GLIOGENESIS","pval":0.87508,"padj":0.97837,"ES":-0.4445,"NES":-0.83768,"nMoreExtreme":18976,"size":98,"leadingEdge":["CX3CR1","GPR183","E2F1","TNFRSF21","CDK1","SLC45A3","DAB1","TP73","OLIG2","DLX1","MYB","TIAM1","TREM2","C5AR1","CCR2","SKI"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNE_RESPONSE_TO_TUMOR_CELL","pval":0.62622,"padj":0.94878,"ES":-0.5916,"NES":-0.83774,"nMoreExtreme":29013,"size":6,"leadingEdge":["KLRK1"]} {"pathway":"GO_MRNA_TRANSCRIPTION","pval":0.68264,"padj":0.94976,"ES":-0.60881,"NES":-0.83836,"nMoreExtreme":25779,"size":21,"leadingEdge":["SOX17","C5AR1"]} {"pathway":"GO_RETROGRADE_AXONAL_TRANSPORT","pval":0.70762,"padj":0.9508,"ES":-0.63675,"NES":-0.8385,"nMoreExtreme":29111,"size":14,"leadingEdge":["MGARP"]} {"pathway":"GO_NEURON_PROJECTION_ORGANIZATION","pval":0.80422,"padj":0.96671,"ES":-0.46296,"NES":-0.83851,"nMoreExtreme":19823,"size":77,"leadingEdge":["EPHB3","INSR","TIAM1","CDK5R1","ITPKA","CUX2","NGEF"]} {"pathway":"GO_ANATOMICAL_STRUCTURE_ARRANGEMENT","pval":0.7074,"padj":0.9508,"ES":-0.63686,"NES":-0.83865,"nMoreExtreme":29102,"size":14,"leadingEdge":["NRP1","DAB1","DLL1","KIF14"]} {"pathway":"GO_SPROUTING_ANGIOGENESIS","pval":0.89524,"padj":0.98309,"ES":-0.44008,"NES":-0.83866,"nMoreExtreme":18406,"size":106,"leadingEdge":["E2F2","E2F8","NRP1","GHRL","DLL1","E2F7","SRPX2","MMRN2","ADTRP","ADGRA2","THBS1"]} {"pathway":"GO_PYRIMIDINE_DEOXYRIBONUCLEOTIDE_BIOSYNTHETIC_PROCESS","pval":0.69582,"padj":0.94995,"ES":-0.62609,"NES":-0.83866,"nMoreExtreme":30697,"size":9,"leadingEdge":["TYMS","SHMT1","DUT"]} {"pathway":"GO_MAMMARY_GLAND_EPITHELIUM_DEVELOPMENT","pval":0.75693,"padj":0.9603,"ES":-0.4823,"NES":-0.83894,"nMoreExtreme":20564,"size":62,"leadingEdge":["LBH","IQGAP3","LRP5","TNFSF11"]} {"pathway":"GO_BRANCH_ELONGATION_INVOLVED_IN_URETERIC_BUD_BRANCHING","pval":0.5847,"padj":0.94167,"ES":-0.57602,"NES":-0.83945,"nMoreExtreme":27532,"size":5,"leadingEdge":["BMP4"]} {"pathway":"GO_OVARIAN_FOLLICLE_DEVELOPMENT","pval":0.69336,"padj":0.94995,"ES":-0.52452,"NES":-0.83968,"nMoreExtreme":21790,"size":42,"leadingEdge":["KITLG","DMC1","FANCG","BCL2","DMRTA1","PTX3","FOXO3"]} {"pathway":"GO_RESPONSE_TO_ALKALOID","pval":0.7699,"padj":0.96082,"ES":-0.47493,"NES":-0.84114,"nMoreExtreme":20101,"size":68,"leadingEdge":["CCNA2","CRHBP","RAD51","BLM","TIAM1","RYR1","GSTM2"]} {"pathway":"GO_MAMMARY_GLAND_DEVELOPMENT","pval":0.92205,"padj":0.987,"ES":-0.43452,"NES":-0.84147,"nMoreExtreme":17884,"size":117,"leadingEdge":["LBH","TNFRSF11A","IQGAP3","LRP5","TNFSF11","PRLR","CYP19A1"]} {"pathway":"GO_EMBRYONIC_PATTERN_SPECIFICATION","pval":0.69288,"padj":0.94995,"ES":-0.52319,"NES":-0.84149,"nMoreExtreme":21578,"size":43,"leadingEdge":["NRP1","DLL1","PCSK6","DISP1","EFNB1","STIL"]} {"pathway":"GO_ANTIBIOTIC_CATABOLIC_PROCESS","pval":0.67226,"padj":0.94905,"ES":-0.60197,"NES":-0.84253,"nMoreExtreme":24929,"size":23,"leadingEdge":["SULT1E1","CAT","ALDH2"]} {"pathway":"GO_SPERM_EGG_RECOGNITION","pval":0.66794,"padj":0.94905,"ES":-0.5726,"NES":-0.84271,"nMoreExtreme":23449,"size":29,"leadingEdge":["CD9"]} {"pathway":"GO_PHARYNGEAL_SYSTEM_DEVELOPMENT","pval":0.68963,"padj":0.94995,"ES":-0.63051,"NES":-0.84277,"nMoreExtreme":27289,"size":17,"leadingEdge":["PLXNA2","BMP4"]} {"pathway":"GO_NUCLEAR_ENVELOPE_REASSEMBLY","pval":0.68471,"padj":0.94976,"ES":-0.62683,"NES":-0.84302,"nMoreExtreme":26813,"size":18,"leadingEdge":["LMNA"]} {"pathway":"GO_RESPONSE_TO_ACETYLCHOLINE","pval":0.6892,"padj":0.94995,"ES":-0.63077,"NES":-0.84311,"nMoreExtreme":27272,"size":17,"leadingEdge":["CDK5R1","CHRM3","RGS10"]} {"pathway":"GO_REGULATION_OF_HISTONE_H3_K4_METHYLATION","pval":0.66981,"padj":0.94905,"ES":-0.59772,"NES":-0.84342,"nMoreExtreme":24561,"size":24,"leadingEdge":["BRCA1","MYB"]} {"pathway":"GO_GLOMERULUS_VASCULATURE_MORPHOGENESIS","pval":0.58372,"padj":0.94167,"ES":-0.57898,"NES":-0.84377,"nMoreExtreme":27486,"size":5,"leadingEdge":["NOTCH3","BMP4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NEUROTRANSMITTER_SECRETION","pval":0.68387,"padj":0.94976,"ES":-0.62739,"NES":-0.84378,"nMoreExtreme":26780,"size":18,"leadingEdge":["SYT1","STX1A","CACNA1D"]} {"pathway":"GO_DENTINOGENESIS","pval":0.54185,"padj":0.9293,"ES":-0.561,"NES":-0.84403,"nMoreExtreme":25984,"size":4,"leadingEdge":["HTRA1"]} {"pathway":"GO_FERTILIZATION","pval":0.83406,"padj":0.97443,"ES":-0.45152,"NES":-0.84517,"nMoreExtreme":18491,"size":94,"leadingEdge":["PLB1","SYT6","CDK1","CD9","PLCD4","CCDC136"]} {"pathway":"GO_MONOSACCHARIDE_BIOSYNTHETIC_PROCESS","pval":0.77527,"padj":0.96098,"ES":-0.47016,"NES":-0.84526,"nMoreExtreme":19408,"size":74,"leadingEdge":["G6PC","PC","SLC25A10","RBP4","KAT2A","C1QTNF3"]} {"pathway":"GO_SECRETORY_GRANULE_ORGANIZATION","pval":0.66254,"padj":0.94905,"ES":-0.58382,"NES":-0.84553,"nMoreExtreme":23653,"size":27,"leadingEdge":["F2RL3","KNL1","CCDC136"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SPROUTING_ANGIOGENESIS","pval":0.66916,"padj":0.94905,"ES":-0.54664,"NES":-0.84565,"nMoreExtreme":22090,"size":36,"leadingEdge":["NRP1","GHRL","DLL1","SRPX2"]} {"pathway":"GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS_BY_VIRUS","pval":0.66329,"padj":0.94905,"ES":-0.58927,"NES":-0.84588,"nMoreExtreme":23890,"size":26,"leadingEdge":["CD28","AP2A2"]} {"pathway":"GO_ESTABLISHMENT_OF_CELL_POLARITY","pval":0.9173,"padj":0.987,"ES":-0.43463,"NES":-0.84602,"nMoreExtreme":17435,"size":121,"leadingEdge":["CDH5","NDC80","FSCN1","WEE1","FRMD4A","CENPA","KIF26B","KIF25","UST","SLC9A3R1","KIF20B","MPP7"]} {"pathway":"GO_VENTRICULAR_SEPTUM_MORPHOGENESIS","pval":0.672,"padj":0.94905,"ES":-0.54061,"NES":-0.84609,"nMoreExtreme":21761,"size":38,"leadingEdge":["TGFBR3","HEY1","BMP4","GJA5"]} {"pathway":"GO_CARBOHYDRATE_PHOSPHORYLATION","pval":0.66906,"padj":0.94905,"ES":-0.60965,"NES":-0.84657,"nMoreExtreme":25042,"size":22,"leadingEdge":["KHK"]} {"pathway":"GO_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION","pval":0.70275,"padj":0.95025,"ES":-0.50693,"NES":-0.84662,"nMoreExtreme":20629,"size":51,"leadingEdge":["E2F1","TP73","BCL2","FZD9","MPV17L"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TISSUE_REMODELING","pval":0.66194,"padj":0.94905,"ES":-0.59525,"NES":-0.84753,"nMoreExtreme":24026,"size":25,"leadingEdge":["TNFRSF11A","ADAM8","PRKCA","TNFSF11"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_DIFFERENTIATION","pval":0.69506,"padj":0.94995,"ES":-0.64158,"NES":-0.8478,"nMoreExtreme":28204,"size":15,"leadingEdge":["DLL1","FZD7","BMP2","RGS4"]} {"pathway":"GO_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVITY","pval":0.66687,"padj":0.94905,"ES":-0.61111,"NES":-0.8486,"nMoreExtreme":24960,"size":22,"leadingEdge":["CACNA1D","GABBR2","CCR2","GNG7"]} {"pathway":"GO_MRNA_TRANSCRIPTION_BY_RNA_POLYMERASE_II","pval":0.69334,"padj":0.94995,"ES":-0.6432,"NES":-0.84993,"nMoreExtreme":28134,"size":15,"leadingEdge":["SOX17","C5AR1"]} {"pathway":"GO_MESODERMAL_CELL_DIFFERENTIATION","pval":0.65731,"padj":0.94878,"ES":-0.59762,"NES":-0.8509,"nMoreExtreme":23858,"size":25,"leadingEdge":["TAL1","SOX17","FGFR1","ETV2","BMP4"]} {"pathway":"GO_LIMB_BUD_FORMATION","pval":0.69058,"padj":0.94995,"ES":-0.63531,"NES":-0.85101,"nMoreExtreme":30466,"size":9,"leadingEdge":["PLXNA2"]} {"pathway":"GO_NEURON_MIGRATION","pval":0.88848,"padj":0.98088,"ES":-0.43851,"NES":-0.85123,"nMoreExtreme":17048,"size":119,"leadingEdge":["NRP1","DAB1","CELSR1","ADGRG1","NEXMIF","FZD3","ASPM","DDIT4","DNER","CDK5R1","DNAAF4","SCRT2","FGFR1"]} {"pathway":"GO_HEAD_MORPHOGENESIS","pval":0.65811,"padj":0.94878,"ES":-0.55799,"NES":-0.85148,"nMoreExtreme":22122,"size":34,"leadingEdge":["SSBP3","SGPL1","SKI"]} {"pathway":"GO_MUSCLE_CELL_DEVELOPMENT","pval":0.92514,"padj":0.987,"ES":-0.43243,"NES":-0.85151,"nMoreExtreme":16546,"size":132,"leadingEdge":["MYOZ2","CDK1","CXADR","MYOM1","PARP2","BCL2","AKAP6","DNER","SGCD","SMYD3","LMNA","RYR1","SKI","LMOD1","BMP4","MYOM3","NRAP","ENG"]} {"pathway":"GO_SMOOTH_MUSCLE_TISSUE_DEVELOPMENT","pval":0.68575,"padj":0.94976,"ES":-0.64103,"NES":-0.85158,"nMoreExtreme":27497,"size":16,"leadingEdge":["BMP4","ENG"]} {"pathway":"GO_REGULATION_OF_PERK_MEDIATED_UNFOLDED_PROTEIN_RESPONSE","pval":0.69869,"padj":0.94995,"ES":-0.64242,"NES":-0.85172,"nMoreExtreme":30431,"size":10,"leadingEdge":["AGR2"]} {"pathway":"GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY","pval":0.82372,"padj":0.97439,"ES":-0.4516,"NES":-0.85266,"nMoreExtreme":17751,"size":99,"leadingEdge":["PID1","AGR2","DAB2","TREM2","ARHGEF16"]} {"pathway":"GO_BRAIN_MORPHOGENESIS","pval":0.65888,"padj":0.94878,"ES":-0.60429,"NES":-0.8527,"nMoreExtreme":24160,"size":24,"leadingEdge":["FZD3","GDF7","FOXO3"]} {"pathway":"GO_TACHYKININ_RECEPTOR_SIGNALING_PATHWAY","pval":0.51818,"padj":0.92533,"ES":-0.5526,"NES":-0.85283,"nMoreExtreme":25328,"size":3,"leadingEdge":["GRK5","GRK2","TAC3"]} {"pathway":"GO_AXONAL_TRANSPORT_OF_MITOCHONDRION","pval":0.68981,"padj":0.94995,"ES":-0.63677,"NES":-0.85296,"nMoreExtreme":30432,"size":9,"leadingEdge":["MGARP"]} {"pathway":"GO_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING","pval":0.71438,"padj":0.9532,"ES":-0.49366,"NES":-0.85307,"nMoreExtreme":19656,"size":60,"leadingEdge":["PKIB","AURKB","NEK2"]} {"pathway":"GO_LIVER_REGENERATION","pval":0.65205,"padj":0.94878,"ES":-0.57965,"NES":-0.85308,"nMoreExtreme":22891,"size":29,"leadingEdge":["TYMS","PCNA"]} {"pathway":"GO_PH_REDUCTION","pval":0.67164,"padj":0.94905,"ES":-0.528,"NES":-0.85319,"nMoreExtreme":20695,"size":44,"leadingEdge":["SLC11A1","ATP6V0D2","BCL2"]} {"pathway":"GO_MALE_MEIOTIC_NUCLEAR_DIVISION","pval":0.64991,"padj":0.94878,"ES":-0.58065,"NES":-0.85455,"nMoreExtreme":22816,"size":29,"leadingEdge":["MEIKIN","DMC1","MYBL1","TRIP13"]} {"pathway":"GO_FATTY_ACID_BETA_OXIDATION","pval":0.72703,"padj":0.95562,"ES":-0.48525,"NES":-0.85469,"nMoreExtreme":19213,"size":66,"leadingEdge":["HADH","ACOX2","IRS2"]} {"pathway":"GO_SKELETAL_MYOFIBRIL_ASSEMBLY","pval":0.69713,"padj":0.94995,"ES":-0.64476,"NES":-0.85483,"nMoreExtreme":30363,"size":10,"leadingEdge":["MYOM1","MYOM3"]} {"pathway":"GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_VASOPRESSIN","pval":0.71956,"padj":0.95459,"ES":-0.64167,"NES":-0.85496,"nMoreExtreme":35951,"size":1,"leadingEdge":["OXTR"]} {"pathway":"GO_VENTRAL_SPINAL_CORD_DEVELOPMENT","pval":0.64767,"padj":0.94878,"ES":-0.58525,"NES":-0.85506,"nMoreExtreme":22929,"size":28,"leadingEdge":["DAB1","OLIG2","IFT172"]} {"pathway":"GO_DRUG_TRANSPORT","pval":0.89505,"padj":0.98309,"ES":-0.43718,"NES":-0.85526,"nMoreExtreme":16493,"size":126,"leadingEdge":["ABCG2","SYT1","SLC11A1","GHRL","ATP8B1","SYT6","SLC25A10","SLC46A1","NTSR1","SNCG","RETN","SLC36A1","CD320"]} {"pathway":"GO_CARBOHYDRATE_DERIVATIVE_TRANSPORT","pval":0.71002,"padj":0.95201,"ES":-0.49366,"NES":-0.85609,"nMoreExtreme":19401,"size":61,"leadingEdge":["G6PC","AGR2","SLC28A3"]} {"pathway":"GO_RESPONSE_TO_BMP","pval":0.86862,"padj":0.97662,"ES":-0.44105,"NES":-0.85616,"nMoreExtreme":16667,"size":119,"leadingEdge":["HTRA1","HTRA3","DLX1","TGFBR3","GDF7","RUNX2","PCSK6","ETV2","BMP6","GREM2","SKI","BMP8A","BMP4","ENG","BMP2"]} {"pathway":"GO_THYMUS_DEVELOPMENT","pval":0.659,"padj":0.94878,"ES":-0.53775,"NES":-0.85664,"nMoreExtreme":20861,"size":41,"leadingEdge":["EPHB3","SLC46A2","CCNB2","BCL2","FOXE1","JARID2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_PERMEABILITY_INVOLVED_IN_APOPTOTIC_PROCESS","pval":0.56545,"padj":0.93517,"ES":-0.55656,"NES":-0.85668,"nMoreExtreme":28133,"size":2,"leadingEdge":["BNIP3","ACAA2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_T_CELL_DIFFERENTIATION_IN_THYMUS","pval":0.65254,"padj":0.94878,"ES":-0.61967,"NES":-0.85684,"nMoreExtreme":29785,"size":7,"leadingEdge":["ADAM8","VNN1"]} {"pathway":"GO_GLUCOSE_CATABOLIC_PROCESS","pval":0.67382,"padj":0.94976,"ES":-0.63067,"NES":-0.85688,"nMoreExtreme":30255,"size":8,"leadingEdge":["LRP5"]} {"pathway":"GO_HEXOSE_CATABOLIC_PROCESS","pval":0.64766,"padj":0.94878,"ES":-0.59729,"NES":-0.85739,"nMoreExtreme":23327,"size":26,"leadingEdge":["LRP5","KHK"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING","pval":0.64562,"padj":0.94878,"ES":-0.59206,"NES":-0.85746,"nMoreExtreme":23049,"size":27,"leadingEdge":["MYOZ2","TRDN","HOMER3","GSTM2"]} {"pathway":"GO_REGULATION_OF_GLIAL_CELL_APOPTOTIC_PROCESS","pval":0.68743,"padj":0.94995,"ES":-0.64042,"NES":-0.85785,"nMoreExtreme":30327,"size":9,"leadingEdge":["DLL1","PRKCA"]} {"pathway":"GO_INOSITOL_TRISPHOSPHATE_BIOSYNTHETIC_PROCESS","pval":0.66502,"padj":0.94905,"ES":-0.63377,"NES":-0.85864,"nMoreExtreme":25658,"size":19,"leadingEdge":["PLCD3","PLCD4","HRH1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY","pval":0.6447,"padj":0.94878,"ES":-0.57017,"NES":-0.85869,"nMoreExtreme":22073,"size":32,"leadingEdge":["TRDN","AKAP6","GSTM2"]} {"pathway":"GO_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT","pval":0.71812,"padj":0.95432,"ES":-0.48563,"NES":-0.86008,"nMoreExtreme":18749,"size":68,"leadingEdge":["S1PR1","TMEM119","ANKH","RFLNB","KL","FBXO5","FZD9"]} {"pathway":"GO_POSITIVE_REGULATION_OF_FC_GAMMA_RECEPTOR_SIGNALING_PATHWAY_INVOLVED_IN_PHAGOCYTOSIS","pval":0.57895,"padj":0.94163,"ES":-0.5907,"NES":-0.86085,"nMoreExtreme":27261,"size":5,"leadingEdge":["APPL2"]} {"pathway":"GO_VISUAL_BEHAVIOR","pval":0.64399,"padj":0.94878,"ES":-0.5533,"NES":-0.86144,"nMoreExtreme":21078,"size":37,"leadingEdge":["HRH2","HRH1"]} {"pathway":"GO_PROTEIN_MONOUBIQUITINATION","pval":0.70815,"padj":0.95107,"ES":-0.48966,"NES":-0.86245,"nMoreExtreme":18714,"size":66,"leadingEdge":["DTL","UHRF1","UBE2T"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_FATTY_ACID","pval":0.65281,"padj":0.94878,"ES":-0.53624,"NES":-0.86249,"nMoreExtreme":20330,"size":43,"leadingEdge":["PID1","PDK4","GNG2","E2F1"]} {"pathway":"GO_REGULATION_OF_MICROTUBULE_POLYMERIZATION","pval":0.65277,"padj":0.94878,"ES":-0.5363,"NES":-0.86258,"nMoreExtreme":20329,"size":43,"leadingEdge":["STMN1","CDK5R1"]} {"pathway":"GO_CARDIAC_CHAMBER_DEVELOPMENT","pval":0.89339,"padj":0.98267,"ES":-0.43546,"NES":-0.86311,"nMoreExtreme":15393,"size":139,"leadingEdge":["NRP1","DHRS3","TGFBR3","HEY1","RBP4","TNNC1","BMP4","GREB1L","GJA5","ENG"]} {"pathway":"GO_ORGANELLE_INHERITANCE","pval":0.68615,"padj":0.94976,"ES":-0.65588,"NES":-0.86369,"nMoreExtreme":28228,"size":14,"leadingEdge":["CDK1"]} {"pathway":"GO_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_PERMEABILITY_INVOLVED_IN_APOPTOTIC_PROCESS","pval":0.67769,"padj":0.94976,"ES":-0.50692,"NES":-0.86418,"nMoreExtreme":19286,"size":56,"leadingEdge":["E2F1","TP73","BCL2","FZD9","MPV17L"]} {"pathway":"GO_ORGANISM_EMERGENCE_FROM_PROTECTIVE_STRUCTURE","pval":0.64578,"padj":0.94878,"ES":-0.6177,"NES":-0.86456,"nMoreExtreme":23947,"size":23,"leadingEdge":["PLPP4","ASF1B"]} {"pathway":"GO_PHOSPHATIDIC_ACID_BIOSYNTHETIC_PROCESS","pval":0.63387,"padj":0.94878,"ES":-0.58785,"NES":-0.86516,"nMoreExtreme":22253,"size":29,"leadingEdge":["LCLAT1","PNPLA3","PLA2G4B"]} {"pathway":"GO_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS","pval":0.77117,"padj":0.96084,"ES":-0.46052,"NES":-0.86553,"nMoreExtreme":16944,"size":96,"leadingEdge":["DAB2","HTRA1","HTRA3","DLX1","TGFBR3","LDLRAD4","CDKN2B","THBS1","CD109","SKI","ENG"]} {"pathway":"GO_GLIAL_CELL_MIGRATION","pval":0.65096,"padj":0.94878,"ES":-0.53043,"NES":-0.86607,"nMoreExtreme":19787,"size":46,"leadingEdge":["CX3CR1","GPR183","DAB1","ADGRG1","TIAM1","CDK5R1","TREM2","CCR2"]} {"pathway":"GO_EXIT_FROM_MITOSIS","pval":0.63043,"padj":0.94878,"ES":-0.57988,"NES":-0.86655,"nMoreExtreme":21772,"size":31,"leadingEdge":["CDCA5","ANLN","UBE2C"]} {"pathway":"GO_ENDOPLASMIC_RETICULUM_ORGANIZATION","pval":0.64948,"padj":0.94878,"ES":-0.53081,"NES":-0.86669,"nMoreExtreme":19742,"size":46,"leadingEdge":["TRDN","REEP1"]} {"pathway":"GO_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS","pval":0.75657,"padj":0.9603,"ES":-0.46373,"NES":-0.86672,"nMoreExtreme":16888,"size":93,"leadingEdge":["PKIB","DSCC1","AURKB","CHTF18","RFC3","RFC5","RFC4","NEK2","PARM1"]} {"pathway":"GO_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY","pval":0.73792,"padj":0.95793,"ES":-0.47146,"NES":-0.86676,"nMoreExtreme":17411,"size":84,"leadingEdge":["S1PR1","NRP1","STMN1","PXN","LIMCH1","FHOD1","ARHGAP6"]} {"pathway":"GO_TETRAHYDROFOLATE_METABOLIC_PROCESS","pval":0.69163,"padj":0.94995,"ES":-0.65919,"NES":-0.86683,"nMoreExtreme":29268,"size":12,"leadingEdge":["TYMS","DHFR","SHMT1"]} {"pathway":"GO_LEFT_RIGHT_PATTERN_FORMATION","pval":0.65579,"padj":0.94878,"ES":-0.63991,"NES":-0.86696,"nMoreExtreme":25302,"size":19,"leadingEdge":["IFT122","DLL1","MNS1","SNAI1","IFT172"]} {"pathway":"GO_REGULATION_OF_LOW_DENSITY_LIPOPROTEIN_PARTICLE_RECEPTOR_BINDING","pval":0.70163,"padj":0.94995,"ES":-0.65077,"NES":-0.86708,"nMoreExtreme":35055,"size":1,"leadingEdge":["ANXA2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MEMBRANE_PERMEABILITY","pval":0.67225,"padj":0.94905,"ES":-0.50692,"NES":-0.86741,"nMoreExtreme":18994,"size":57,"leadingEdge":["E2F1","TP73","BCL2","FZD9","MPV17L"]} {"pathway":"GO_INTERLEUKIN_5_PRODUCTION","pval":0.68287,"padj":0.94976,"ES":-0.65903,"NES":-0.86783,"nMoreExtreme":28093,"size":14,"leadingEdge":["TNFRSF21"]} {"pathway":"GO_SPINDLE_MIDZONE_ASSEMBLY","pval":0.67008,"padj":0.94905,"ES":-0.63901,"NES":-0.86821,"nMoreExtreme":30087,"size":8,"leadingEdge":["AURKB","KIF4A","RACGAP1"]} {"pathway":"GO_ENDOCARDIAL_CUSHION_MORPHOGENESIS","pval":0.6333,"padj":0.94878,"ES":-0.60497,"NES":-0.86841,"nMoreExtreme":22810,"size":26,"leadingEdge":["SNAI1","HEY1","ENG","BMP2"]} {"pathway":"GO_RHYTHMIC_PROCESS","pval":0.99613,"padj":1,"ES":-0.41667,"NES":-0.86884,"nMoreExtreme":11827,"size":215,"leadingEdge":["TNFRSF11A","TOP2A","GHRL","TYMS","SGPL1","PROK2","TYRO3","MAP2K6","ADCY1","SUV39H2","PHLPP1","CDK5R1","LGR4","RETN","PCNA","USP2","ID3","PTX3","FOXO3"]} {"pathway":"GO_LENS_MORPHOGENESIS_IN_CAMERA_TYPE_EYE","pval":0.66433,"padj":0.94905,"ES":-0.65002,"NES":-0.86885,"nMoreExtreme":26288,"size":17,"leadingEdge":["NECTIN1","SKI","BMP4"]} {"pathway":"GO_CARTILAGE_DEVELOPMENT","pval":0.91172,"padj":0.98542,"ES":-0.43104,"NES":-0.86941,"nMoreExtreme":14055,"size":160,"leadingEdge":["GHRL","TYMS","MAF","RFLNB","SNAI1","RUNX2","FGFR1","BMP6","BMP8A","EVC","BMP4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_EXTRACELLULAR_MATRIX_DISASSEMBLY","pval":0.66919,"padj":0.94905,"ES":-0.64047,"NES":-0.87019,"nMoreExtreme":30047,"size":8,"leadingEdge":["FSCN1","MELTF"]} {"pathway":"GO_PYRIMIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS","pval":0.64857,"padj":0.94878,"ES":-0.52311,"NES":-0.87038,"nMoreExtreme":19237,"size":50,"leadingEdge":["LCLAT1","TYMS","TK1","SHMT1"]} {"pathway":"GO_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY","pval":0.77662,"padj":0.96098,"ES":-0.45635,"NES":-0.87084,"nMoreExtreme":15877,"size":107,"leadingEdge":["LBH","DAB2","BRCA1","KANK2","DNAAF4","CCNE1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MEGAKARYOCYTE_DIFFERENTIATION","pval":0.6169,"padj":0.94878,"ES":-0.615,"NES":-0.87088,"nMoreExtreme":28581,"size":6,"leadingEdge":["TESC","HMGB2"]} {"pathway":"GO_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS","pval":0.62812,"padj":0.94878,"ES":-0.55657,"NES":-0.87107,"nMoreExtreme":20340,"size":38,"leadingEdge":["PDK4","APPL2"]} {"pathway":"GO_ADAPTIVE_THERMOGENESIS","pval":0.8154,"padj":0.971,"ES":-0.44717,"NES":-0.87108,"nMoreExtreme":15384,"size":122,"leadingEdge":["GHRL","EPAS1","G0S2","APPL2","PDGFC","MAP2K6","ADAMTS5","HADH","PRLR","ADRB1","GPR3","LGR4","ACOT11","GATM","NOVA1","CCR2","BMP8A"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NEUROBLAST_PROLIFERATION","pval":0.66633,"padj":0.94905,"ES":-0.65661,"NES":-0.87227,"nMoreExtreme":26718,"size":16,"leadingEdge":["CX3CR1","FZD3","ASPM"]} {"pathway":"GO_CARDIAC_MUSCLE_CELL_DIFFERENTIATION","pval":0.73691,"padj":0.95787,"ES":-0.46689,"NES":-0.87264,"nMoreExtreme":16449,"size":93,"leadingEdge":["CDK1","CXADR","DLL1","MYOM1","PARP2","AKAP6","SGCD","LMNA","FZD7","KAT2A","BMP4","MYOM3","NRAP"]} {"pathway":"GO_MATERNAL_PLACENTA_DEVELOPMENT","pval":0.62168,"padj":0.94878,"ES":-0.58831,"NES":-0.87266,"nMoreExtreme":21641,"size":30,"leadingEdge":["GHRL","STOX2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_COLD_INDUCED_THERMOGENESIS","pval":0.69674,"padj":0.94995,"ES":-0.48661,"NES":-0.87293,"nMoreExtreme":17561,"size":73,"leadingEdge":["GHRL","EPAS1","G0S2","APPL2","PDGFC","HADH","PRLR","ADRB1","GPR3","GATM","CCR2"]} {"pathway":"GO_PROTEIN_NITROSYLATION","pval":0.68459,"padj":0.94976,"ES":-0.66409,"NES":-0.87319,"nMoreExtreme":28588,"size":13,"leadingEdge":["ACE"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_GONADOTROPIN_STIMULUS","pval":0.68695,"padj":0.94995,"ES":-0.66429,"NES":-0.87354,"nMoreExtreme":29070,"size":12,"leadingEdge":["CCNA2"]} {"pathway":"GO_MESENCHYME_DEVELOPMENT","pval":0.99163,"padj":1,"ES":-0.41858,"NES":-0.87401,"nMoreExtreme":11613,"size":218,"leadingEdge":["NRP1","KITLG","SEMA6B","DAB2","HTR2B","RFLNB","BNC2","BCL2","SEMA3G","TGFBR3","LDLRAD4","SNAI1","SEMA6C","TIAM1","HEY1","FAM83D","FGFR1","SEMA4C","EFNB1","RBM24","BMP4","DACT3","ENG"]} {"pathway":"GO_PHOSPHATIDYLINOSITOL_BIOSYNTHETIC_PROCESS","pval":0.77026,"padj":0.96082,"ES":-0.45678,"NES":-0.8744,"nMoreExtreme":15579,"size":109,"leadingEdge":["HTR2B","INPP4B","PIK3C2B","PTPN13"]} {"pathway":"GO_CARDIOCYTE_DIFFERENTIATION","pval":0.78702,"padj":0.96311,"ES":-0.4523,"NES":-0.87454,"nMoreExtreme":15357,"size":116,"leadingEdge":["CDK1","CXADR","SOX17","DLL1","MYOM1","PARP2","AKAP6","SGCD","TGFBR3","LMNA","FZD7","KAT2A","BMP4","MYOM3","NRAP"]} {"pathway":"GO_EAR_DEVELOPMENT","pval":0.86741,"padj":0.97662,"ES":-0.43637,"NES":-0.87576,"nMoreExtreme":13783,"size":154,"leadingEdge":["MAF","MCM2","C1QTNF5","CCNA2","SOBP","CELSR1","DLL1","SLC4A7","FZD3","MYO7A","BCL2"]} {"pathway":"GO_RECEPTOR_INTERNALIZATION","pval":0.71784,"padj":0.95427,"ES":-0.47276,"NES":-0.87609,"nMoreExtreme":16574,"size":88,"leadingEdge":["NECAB2","DNM1","HTR2B","CD9","CALCRL","ACKR3","LRRTM1"]} {"pathway":"GO_MESONEPHRIC_DUCT_DEVELOPMENT","pval":0.64663,"padj":0.94878,"ES":-0.63364,"NES":-0.87615,"nMoreExtreme":29515,"size":7,"leadingEdge":["GREB1L"]} {"pathway":"GO_REGULATION_OF_CAMP_MEDIATED_SIGNALING","pval":0.61654,"padj":0.94878,"ES":-0.59073,"NES":-0.87626,"nMoreExtreme":21462,"size":30,"leadingEdge":["PDE3B","PDE3A","PRKCA","PDE2A"]} {"pathway":"GO_ORGAN_GROWTH","pval":0.8476,"padj":0.97573,"ES":-0.43945,"NES":-0.87669,"nMoreExtreme":14070,"size":146,"leadingEdge":["S1PR1","CDK1","CXADR","DLL1","TP73","BNC2","PARP2","BCL2","AKAP6","TGFBR3","CYP19A1","RBP4","FGFR1","EVC","JARID2"]} {"pathway":"GO_ESTABLISHMENT_OF_MITOCHONDRION_LOCALIZATION","pval":0.63723,"padj":0.94878,"ES":-0.63673,"NES":-0.87681,"nMoreExtreme":24064,"size":21,"leadingEdge":["MGARP"]} {"pathway":"GO_RNA_DEPENDENT_DNA_BIOSYNTHETIC_PROCESS","pval":0.6787,"padj":0.94976,"ES":-0.49364,"NES":-0.87694,"nMoreExtreme":17635,"size":69,"leadingEdge":["PKIB","AURKB","NEK2"]} {"pathway":"GO_LEUKOTRIENE_METABOLIC_PROCESS","pval":0.68799,"padj":0.94995,"ES":-0.66659,"NES":-0.87746,"nMoreExtreme":29515,"size":11,"leadingEdge":["LTC4S","ALOX15"]} {"pathway":"GO_SPINAL_CORD_DEVELOPMENT","pval":0.68084,"padj":0.94976,"ES":-0.49055,"NES":-0.87801,"nMoreExtreme":17276,"size":72,"leadingEdge":["TAL1","IFT122","DAB1","DLL1","OLIG2","GDF7","IFT172"]} {"pathway":"GO_CD4_POSITIVE_CD25_POSITIVE_ALPHA_BETA_REGULATORY_T_CELL_DIFFERENTIATION","pval":0.54501,"padj":0.93088,"ES":-0.57055,"NES":-0.87821,"nMoreExtreme":27116,"size":2,"leadingEdge":["FUT7","LGALS9"]} {"pathway":"GO_RIBOSE_PHOSPHATE_BIOSYNTHETIC_PROCESS","pval":0.85937,"padj":0.97645,"ES":-0.43665,"NES":-0.87927,"nMoreExtreme":13357,"size":158,"leadingEdge":["PID1","PDK4","AK1","ADCY1","ADCY4","TREM2","GUCY1A2"]} {"pathway":"GO_RESPONSE_TO_FOOD","pval":0.63708,"padj":0.94878,"ES":-0.6446,"NES":-0.87994,"nMoreExtreme":24327,"size":20,"leadingEdge":["G6PC","GHRL"]} {"pathway":"GO_OVULATION_CYCLE","pval":0.62744,"padj":0.94878,"ES":-0.5292,"NES":-0.8805,"nMoreExtreme":18610,"size":50,"leadingEdge":["SGPL1","TYRO3","MAP2K6","RETN","PCNA","PTX3","FOXO3"]} {"pathway":"GO_REGULATION_OF_KERATINOCYTE_MIGRATION","pval":0.67884,"padj":0.94976,"ES":-0.67025,"NES":-0.8813,"nMoreExtreme":28348,"size":13,"leadingEdge":["MMP9","HBEGF"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_ACID_CHEMICAL","pval":0.86833,"padj":0.97662,"ES":-0.435,"NES":-0.88136,"nMoreExtreme":12905,"size":167,"leadingEdge":["PID1","PDK4","GNG2","TESC","E2F1","CASTOR1","SESN3","PDGFC","SESN1","SHMT1","MYB","FZD7","FFAR3"]} {"pathway":"GO_DENDRITE_DEVELOPMENT","pval":0.92579,"padj":0.987,"ES":-0.42718,"NES":-0.88214,"nMoreExtreme":12138,"size":195,"leadingEdge":["EPHB3","NRP1","GHRL","FSTL4","SDC2","DAB1","RAB17","CDC20","TIAM1","CDK5R1","ITPKA","CUX2","SEZ6","CAMK1","CELSR2","NGEF"]} {"pathway":"GO_STEM_CELL_FATE_COMMITMENT","pval":0.5273,"padj":0.92669,"ES":-0.58651,"NES":-0.8824,"nMoreExtreme":25286,"size":4,"leadingEdge":["SOX17"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION","pval":0.64391,"padj":0.94878,"ES":-0.65641,"NES":-0.88281,"nMoreExtreme":25215,"size":18,"leadingEdge":["RUNX2","BMP6"]} {"pathway":"GO_ESTABLISHMENT_OF_MITOTIC_SPINDLE_LOCALIZATION","pval":0.61334,"padj":0.94703,"ES":-0.61505,"NES":-0.88288,"nMoreExtreme":22091,"size":26,"leadingEdge":["NUSAP1","NDC80","ESPL1","CENPA"]} {"pathway":"GO_ASSOCIATIVE_LEARNING","pval":0.62998,"padj":0.94878,"ES":-0.5226,"NES":-0.88352,"nMoreExtreme":18155,"size":54,"leadingEdge":["NRGN","HRH2","ASIC1","HRH1","FOS","RIN1"]} {"pathway":"GO_REGULATION_OF_CARDIOCYTE_DIFFERENTIATION","pval":0.61028,"padj":0.94703,"ES":-0.55205,"NES":-0.88376,"nMoreExtreme":19179,"size":42,"leadingEdge":["SOX17","DLL1","PARP2","AKAP6","FZD7","KAT2A","BMP4","BMP2","RGS4"]} {"pathway":"GO_EATING_BEHAVIOR","pval":0.66288,"padj":0.94905,"ES":-0.66897,"NES":-0.88398,"nMoreExtreme":26898,"size":15,"leadingEdge":["GHRL"]} {"pathway":"GO_SOMITOGENESIS","pval":0.62866,"padj":0.94878,"ES":-0.52306,"NES":-0.88431,"nMoreExtreme":18117,"size":54,"leadingEdge":["PLXNA2","XRCC2","DLL1","KAT2A"]} {"pathway":"GO_FORMATION_OF_PRIMARY_GERM_LAYER","pval":0.71267,"padj":0.95313,"ES":-0.46929,"NES":-0.8844,"nMoreExtreme":15454,"size":98,"leadingEdge":["TAL1","LAMB3","MMP9","SOX17","ITGB5","ATOH8","SNAI1","WLS","FZD7","FGFR1","MMP8","ETV2","BMP4"]} {"pathway":"GO_SLEEP","pval":0.66241,"padj":0.94905,"ES":-0.6694,"NES":-0.88456,"nMoreExtreme":26879,"size":15,"leadingEdge":["GHRL","FOS","IL18","CSF2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CYTOKINESIS","pval":0.64442,"padj":0.94878,"ES":-0.63979,"NES":-0.88466,"nMoreExtreme":29414,"size":7,"leadingEdge":["E2F8","AURKB","E2F7"]} {"pathway":"GO_FEVER_GENERATION","pval":0.67535,"padj":0.94976,"ES":-0.66049,"NES":-0.88473,"nMoreExtreme":29794,"size":9,"leadingEdge":["TNFRSF11A","TNFSF11"]} {"pathway":"GO_OSTEOCLAST_FUSION","pval":0.5727,"padj":0.94033,"ES":-0.60737,"NES":-0.88514,"nMoreExtreme":26967,"size":5,"leadingEdge":["SH3PXD2A","CD109"]} {"pathway":"GO_HISTONE_H4_K16_ACETYLATION","pval":0.62677,"padj":0.94878,"ES":-0.64325,"NES":-0.88579,"nMoreExtreme":23669,"size":21,"leadingEdge":["BRCA1"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_SYNAPSE","pval":0.64128,"padj":0.94878,"ES":-0.5093,"NES":-0.8859,"nMoreExtreme":17422,"size":62,"leadingEdge":["LRRC7","LRRTM1","NLGN2"]} {"pathway":"GO_MONOSACCHARIDE_CATABOLIC_PROCESS","pval":0.60238,"padj":0.94684,"ES":-0.59728,"NES":-0.88598,"nMoreExtreme":20969,"size":30,"leadingEdge":["LRP5","KHK"]} {"pathway":"GO_FEMALE_GENITALIA_DEVELOPMENT","pval":0.65366,"padj":0.94878,"ES":-0.66695,"NES":-0.88601,"nMoreExtreme":26210,"size":16,"leadingEdge":["MERTK","TYRO3","CYP19A1","RBP4"]} {"pathway":"GO_REGULATION_OF_BMP_SIGNALING_PATHWAY","pval":0.64975,"padj":0.94878,"ES":-0.50187,"NES":-0.88628,"nMoreExtreme":17049,"size":67,"leadingEdge":["HTRA1","HTRA3","DLX1","PCSK6","GREM2","SKI","BMP4","ENG"]} {"pathway":"GO_CELLULAR_CARBOHYDRATE_METABOLIC_PROCESS","pval":0.93274,"padj":0.98762,"ES":-0.42595,"NES":-0.88665,"nMoreExtreme":11246,"size":212,"leadingEdge":["PCDH12","G6PC","PDK4","SLC45A3","INSR","KHK","PASK","INPP5A","DDIT4","IGFBP3","HRH1","NTSR1","ITPKA","IMPA2","C1QTNF3","IRS2","PPP1R3G"]} {"pathway":"GO_MEIOTIC_CELL_CYCLE_PHASE_TRANSITION","pval":0.57228,"padj":0.94008,"ES":-0.60848,"NES":-0.88676,"nMoreExtreme":26947,"size":5,"leadingEdge":["CDC25A","CDC25C","TTK"]} {"pathway":"GO_REGULATION_OF_EOSINOPHIL_MIGRATION","pval":0.57226,"padj":0.94008,"ES":-0.60852,"NES":-0.88682,"nMoreExtreme":26946,"size":5,"leadingEdge":["ADAM8"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELL_DIVISION","pval":0.65997,"padj":0.94905,"ES":-0.6715,"NES":-0.88734,"nMoreExtreme":26780,"size":15,"leadingEdge":["E2F8","AURKB","ORC6","E2F7","ASPM","BLM"]} {"pathway":"GO_ASTROCYTE_CELL_MIGRATION","pval":0.64358,"padj":0.94878,"ES":-0.64178,"NES":-0.88741,"nMoreExtreme":29376,"size":7,"leadingEdge":["GPR183","CCR2"]} {"pathway":"GO_RESPONSE_TO_FOLIC_ACID","pval":0.67394,"padj":0.94976,"ES":-0.6628,"NES":-0.88783,"nMoreExtreme":29732,"size":9,"leadingEdge":["TYMS"]} {"pathway":"GO_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR_VIA_HOMOLOGOUS_RECOMBINATION","pval":0.60326,"padj":0.94684,"ES":-0.55254,"NES":-0.88869,"nMoreExtreme":18787,"size":43,"leadingEdge":["POLQ","RAD51","FANCB","CHEK1","BLM","RAD51AP1","USP51"]} {"pathway":"GO_HEAT_GENERATION","pval":0.66566,"padj":0.94905,"ES":-0.67526,"NES":-0.88921,"nMoreExtreme":27385,"size":14,"leadingEdge":["TNFRSF11A","TNFSF11","ADRB1"]} {"pathway":"GO_KERATINOCYTE_MIGRATION","pval":0.65009,"padj":0.94878,"ES":-0.67025,"NES":-0.8904,"nMoreExtreme":26067,"size":16,"leadingEdge":["MMP9","HBEGF"]} {"pathway":"GO_REGULATION_OF_CELLULAR_RESPONSE_TO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_STIMULUS","pval":0.64255,"padj":0.94878,"ES":-0.66638,"NES":-0.89072,"nMoreExtreme":25426,"size":17,"leadingEdge":["DLL1","ADGRA2"]} {"pathway":"GO_REGULATION_OF_HEART_GROWTH","pval":0.61796,"padj":0.94878,"ES":-0.52253,"NES":-0.8908,"nMoreExtreme":17586,"size":56,"leadingEdge":["CDK1","CXADR","TP73","PARP2","AKAP6","TGFBR3","RBP4","FGFR1","JARID2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SKELETAL_MUSCLE_CELL_DIFFERENTIATION","pval":0.61152,"padj":0.94703,"ES":-0.62963,"NES":-0.89159,"nMoreExtreme":28332,"size":6,"leadingEdge":["RBM24"]} {"pathway":"GO_OVULATION_CYCLE_PROCESS","pval":0.59359,"padj":0.94378,"ES":-0.58442,"NES":-0.89182,"nMoreExtreme":19953,"size":34,"leadingEdge":["SGPL1","MAP2K6","RETN","PTX3","FOXO3"]} {"pathway":"GO_TUBE_FORMATION","pval":0.74637,"padj":0.96025,"ES":-0.45468,"NES":-0.89232,"nMoreExtreme":13556,"size":129,"leadingEdge":["IFT122","EDA","CELSR1","FZD3","ATOH8","IRX3","GDF7","PRKACB","IFT172","CC2D2A","SEMA4C","KAT2A","SKI","STIL","BMP4","KIF20B","SHROOM3"]} {"pathway":"GO_TRANSLESION_SYNTHESIS","pval":0.59573,"padj":0.94465,"ES":-0.56049,"NES":-0.89286,"nMoreExtreme":18858,"size":41,"leadingEdge":["PCLAF","DTL","POLE2","RFC3","RFC5","RFC4"]} {"pathway":"GO_HYALURONAN_CATABOLIC_PROCESS","pval":0.66155,"padj":0.94905,"ES":-0.67962,"NES":-0.89495,"nMoreExtreme":27216,"size":14,"leadingEdge":["LYVE1","HMMR"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_CISPLATIN","pval":0.52277,"padj":0.92585,"ES":-0.59534,"NES":-0.8957,"nMoreExtreme":25069,"size":4,"leadingEdge":["DDX11"]} {"pathway":"GO_REGULATION_OF_ASTROCYTE_DIFFERENTIATION","pval":0.59142,"padj":0.94324,"ES":-0.61963,"NES":-0.89738,"nMoreExtreme":21114,"size":27,"leadingEdge":["DAB1","TREM2","C5AR1","BMP2"]} {"pathway":"GO_DNA_TEMPLATED_TRANSCRIPTION_INITIATION","pval":0.8606,"padj":0.97645,"ES":-0.43237,"NES":-0.89791,"nMoreExtreme":10636,"size":207,"leadingEdge":["E2F2","CDK1","MAML3","NOTCH3","RUNX2"]} {"pathway":"GO_APPENDAGE_MORPHOGENESIS","pval":0.70431,"padj":0.9504,"ES":-0.46279,"NES":-0.89837,"nMoreExtreme":13514,"size":119,"leadingEdge":["PLXNA2","IFT122","RUNX2","FGFR1","SKI","BMP4","GJA5"]} {"pathway":"GO_DEVELOPMENTAL_PIGMENTATION","pval":0.58306,"padj":0.94167,"ES":-0.58484,"NES":-0.8986,"nMoreExtreme":19444,"size":35,"leadingEdge":["KITLG","OCA2","BCL2","TYRP1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SIGNALING_RECEPTOR_ACTIVITY","pval":0.58346,"padj":0.94167,"ES":-0.59307,"NES":-0.899,"nMoreExtreme":19777,"size":33,"leadingEdge":["TAL1","NCAPG2","ADRA2B"]} {"pathway":"GO_ANATOMICAL_STRUCTURE_MATURATION","pval":0.71724,"padj":0.95386,"ES":-0.45826,"NES":-0.89935,"nMoreExtreme":13027,"size":129,"leadingEdge":["S1PR1","CX3CR1","TYMS","XYLT1","TAL1","DMC1","CDH5","PDE3A","RFLNB","FBXO5","BCL2","TRIP13","CDK5R1"]} {"pathway":"GO_GOLGI_LOCALIZATION","pval":0.65798,"padj":0.94878,"ES":-0.68316,"NES":-0.89961,"nMoreExtreme":27069,"size":14,"leadingEdge":["DAB1","SLC9A3R1"]} {"pathway":"GO_RECEPTOR_LOCALIZATION_TO_SYNAPSE","pval":0.58438,"padj":0.94167,"ES":-0.55934,"NES":-0.89964,"nMoreExtreme":18199,"size":43,"leadingEdge":["LRRC7"]} {"pathway":"GO_POSITIVE_REGULATION_OF_GROWTH","pval":0.84125,"padj":0.97458,"ES":-0.43421,"NES":-0.89967,"nMoreExtreme":10640,"size":202,"leadingEdge":["SYT1","NRP1","AGR2","GHRL","CDK1","HBEGF","DLL1","INSR","CPNE5","PARP2","BCL2","AKAP6","TGFBR3"]} {"pathway":"GO_ONE_CARBON_METABOLIC_PROCESS","pval":0.61563,"padj":0.94824,"ES":-0.65917,"NES":-0.89983,"nMoreExtreme":23508,"size":20,"leadingEdge":["TYMS","DHFR","SHMT1"]} {"pathway":"GO_DEVELOPMENTAL_MATURATION","pval":0.85547,"padj":0.97645,"ES":-0.4327,"NES":-0.90011,"nMoreExtreme":10428,"size":210,"leadingEdge":["S1PR1","CX3CR1","TYMS","XYLT1","TAL1","EPAS1","DMC1","CDH5","PDE3A","RFLNB","KIF14","NFIA","FBXO5","BCL2","CDC20","TRIP13","CDK5R1","RUNX2","SEZ6","FGFR1","RYR1","IGSF21"]} {"pathway":"GO_ENDOTHELIUM_DEVELOPMENT","pval":0.66558,"padj":0.94905,"ES":-0.47686,"NES":-0.90035,"nMoreExtreme":14343,"size":99,"leadingEdge":["S1PR1","NRP1","CDH5","COL23A1","SOX17","DLL1","SLC40A1","PDE2A","ATOH8","HEY1","COL4A4","ETV2","BMP6","BMP4","GJA5","ENG"]} {"pathway":"GO_LIPID_HOMEOSTASIS","pval":0.66558,"padj":0.94905,"ES":-0.47686,"NES":-0.90036,"nMoreExtreme":14343,"size":99,"leadingEdge":["G6PC","LRP5","LPL","PNPLA3","TMEM97","RBP1","ACSM2A","ACOX2","C1QTNF3","IRS2","RCN3","CD24","IL18"]} {"pathway":"GO_DIAPHRAGM_DEVELOPMENT","pval":0.65728,"padj":0.94878,"ES":-0.66291,"NES":-0.90068,"nMoreExtreme":29512,"size":8,"leadingEdge":["DISP1"]} {"pathway":"GO_REGULATION_OF_PROTEIN_HOMODIMERIZATION_ACTIVITY","pval":0.6144,"padj":0.94714,"ES":-0.65999,"NES":-0.90094,"nMoreExtreme":23461,"size":20,"leadingEdge":["BCL2"]} {"pathway":"GO_INTERLEUKIN_17_SECRETION","pval":0.52114,"padj":0.9256,"ES":-0.59892,"NES":-0.90108,"nMoreExtreme":24991,"size":4,"leadingEdge":["OSM"]} {"pathway":"GO_NEURON_PROJECTION_EXTENSION_INVOLVED_IN_NEURON_PROJECTION_GUIDANCE","pval":0.57933,"padj":0.94163,"ES":-0.59477,"NES":-0.90157,"nMoreExtreme":19637,"size":33,"leadingEdge":["NRP1","SEMA6B","SEMA3G","SEMA6C","SEMA4C"]} {"pathway":"GO_PROXIMAL_DISTAL_PATTERN_FORMATION","pval":0.59991,"padj":0.94564,"ES":-0.64449,"NES":-0.90204,"nMoreExtreme":22246,"size":23,"leadingEdge":["DLL1","DLX1","IRX3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_GLUCOSE_TRANSMEMBRANE_TRANSPORT","pval":0.65592,"padj":0.94878,"ES":-0.68505,"NES":-0.9021,"nMoreExtreme":26984,"size":14,"leadingEdge":["PID1","APPL2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_OSTEOBLAST_PROLIFERATION","pval":0.65674,"padj":0.94878,"ES":-0.66398,"NES":-0.90214,"nMoreExtreme":29488,"size":8,"leadingEdge":["BCL2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_HISTONE_H3_K4_METHYLATION","pval":0.64696,"padj":0.94878,"ES":-0.6839,"NES":-0.90372,"nMoreExtreme":26252,"size":15,"leadingEdge":["BRCA1","MYB"]} {"pathway":"GO_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY_INVOLVED_IN_DORSAL_VENTRAL_NEURAL_TUBE_PATTERNING","pval":0.65596,"padj":0.94878,"ES":-0.66562,"NES":-0.90437,"nMoreExtreme":29453,"size":8,"leadingEdge":["PRKACB"]} {"pathway":"GO_BONE_MARROW_DEVELOPMENT","pval":0.65576,"padj":0.94878,"ES":-0.66588,"NES":-0.90472,"nMoreExtreme":29444,"size":8,"leadingEdge":["LRP5"]} {"pathway":"GO_POSITIVE_REGULATION_OF_RECEPTOR_BINDING","pval":0.65558,"padj":0.94878,"ES":-0.66611,"NES":-0.90503,"nMoreExtreme":29436,"size":8,"leadingEdge":["NRP1","MMP9"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY","pval":0.5868,"padj":0.94167,"ES":-0.53312,"NES":-0.90541,"nMoreExtreme":16788,"size":55,"leadingEdge":["AGR2","TREM2","ARHGEF16"]} {"pathway":"GO_MITOCHONDRIAL_MEMBRANE_ORGANIZATION","pval":0.67854,"padj":0.94976,"ES":-0.46592,"NES":-0.90552,"nMoreExtreme":12936,"size":120,"leadingEdge":["E2F1","TP73","BCL2","FZD9","MPV17L"]} {"pathway":"GO_DEVELOPMENT_OF_PRIMARY_SEXUAL_CHARACTERISTICS","pval":0.74736,"padj":0.96029,"ES":-0.44727,"NES":-0.90622,"nMoreExtreme":11107,"size":167,"leadingEdge":["TESC","KITLG","DMC1","SGPL1","ADGRG1","INSR","MAMLD1","FANCG","ASPM","BCL2","HMGB2","RRM1","DMRTA1","CYP19A1","NUDT1","RETN","CBX2"]} {"pathway":"GO_LEARNING","pval":0.65288,"padj":0.94878,"ES":-0.47746,"NES":-0.90637,"nMoreExtreme":13684,"size":103,"leadingEdge":["NRGN","HRH2","ASIC1","INSR","HRH1","NTSR1","FOS","PRKN","RIN1"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_INSULIN_LIKE_GROWTH_FACTOR_STIMULUS","pval":0.65509,"padj":0.94878,"ES":-0.66735,"NES":-0.90672,"nMoreExtreme":29414,"size":8,"leadingEdge":["CCNA2"]} {"pathway":"GO_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR","pval":0.73907,"padj":0.95841,"ES":-0.448,"NES":-0.90882,"nMoreExtreme":10890,"size":169,"leadingEdge":["EXO1","BRCA1","AURKB","NUAK1","RFC3","TP73","RFC5","RFC4","DNA2","CHEK1","TPX2","BCL2","BLM","SNAI1","CDK5R1","TP53INP1"]} {"pathway":"GO_SENSORY_ORGAN_MORPHOGENESIS","pval":0.75289,"padj":0.9603,"ES":-0.44475,"NES":-0.90883,"nMoreExtreme":10605,"size":179,"leadingEdge":["IFT122","LRP5","SOBP","CELSR1","DLL1","FZD3","MYO7A","BCL2","NECTIN1","RBP4","FGFR1","SLC9A3R1","SKI","BMP4","THRB"]} {"pathway":"GO_PURINE_NUCLEOSIDE_BIOSYNTHETIC_PROCESS","pval":0.60597,"padj":0.94703,"ES":-0.6658,"NES":-0.90888,"nMoreExtreme":23139,"size":20,"leadingEdge":["PRTFDC1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NUCLEOTIDE_BIOSYNTHETIC_PROCESS","pval":0.63448,"padj":0.94878,"ES":-0.68446,"NES":-0.90928,"nMoreExtreme":25441,"size":16,"leadingEdge":["PID1","TREM2"]} {"pathway":"GO_CELL_JUNCTION_ORGANIZATION","pval":0.8716,"padj":0.97717,"ES":-0.4294,"NES":-0.90965,"nMoreExtreme":8735,"size":251,"leadingEdge":["NRP1","LAMB3","CDH5","CXADR","FSCN1","PRKCA","GJC1","CD9","LIMCH1","ACE","BCL2","NECTIN1","CDH26","SNAI1","ARHGAP6","THBS1","MARVELD3"]} {"pathway":"GO_RESPONSE_TO_ESTROGEN","pval":0.58351,"padj":0.94167,"ES":-0.53007,"NES":-0.90998,"nMoreExtreme":16325,"size":58,"leadingEdge":["GHRL","BRCA1","CRHBP"]} {"pathway":"GO_REGULATION_OF_HISTONE_H4_K16_ACETYLATION","pval":0.60701,"padj":0.94703,"ES":-0.64326,"NES":-0.9109,"nMoreExtreme":28123,"size":6,"leadingEdge":["BRCA1"]} {"pathway":"GO_SYMPATHETIC_NERVOUS_SYSTEM_DEVELOPMENT","pval":0.64008,"padj":0.94878,"ES":-0.68976,"NES":-0.91146,"nMoreExtreme":25973,"size":15,"leadingEdge":["NRP1","FZD3"]} {"pathway":"GO_MEIOSIS_II_CELL_CYCLE_PROCESS","pval":0.65316,"padj":0.94878,"ES":-0.67134,"NES":-0.91213,"nMoreExtreme":29327,"size":8,"leadingEdge":["MEIKIN","BUB1B","BUB1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_AXON_EXTENSION","pval":0.56182,"padj":0.93517,"ES":-0.58337,"NES":-0.91301,"nMoreExtreme":18193,"size":38,"leadingEdge":["NRP1","SEMA6B","SEMA3G","SEMA6C","CDK5R1","SEMA4C"]} {"pathway":"GO_POSITIVE_REGULATION_OF_FEEDING_BEHAVIOR","pval":0.56589,"padj":0.93517,"ES":-0.62778,"NES":-0.91489,"nMoreExtreme":26646,"size":5,"leadingEdge":["GHRL"]} {"pathway":"GO_OLIGODENDROCYTE_DIFFERENTIATION","pval":0.59323,"padj":0.94378,"ES":-0.50551,"NES":-0.91557,"nMoreExtreme":14622,"size":77,"leadingEdge":["CDKN2C","TNFRSF21","OLIG1","SLC45A3","TP73","CD9","OLIG2","DLX1"]} {"pathway":"GO_CIRCADIAN_RHYTHM","pval":0.68223,"padj":0.94976,"ES":-0.45706,"NES":-0.91557,"nMoreExtreme":11043,"size":151,"leadingEdge":["TNFRSF11A","TOP2A","GHRL","TYMS","PROK2","ADCY1","SUV39H2","PHLPP1","LGR4"]} {"pathway":"GO_ANTRAL_OVARIAN_FOLLICLE_GROWTH","pval":0.60584,"padj":0.94703,"ES":-0.64669,"NES":-0.91575,"nMoreExtreme":28069,"size":6,"leadingEdge":["PTX3","FOXO3"]} {"pathway":"GO_PROTEIN_K11_LINKED_UBIQUITINATION","pval":0.56246,"padj":0.93517,"ES":-0.62229,"NES":-0.91584,"nMoreExtreme":19746,"size":29,"leadingEdge":["UBE2T","UBE2C","PRKN"]} {"pathway":"GO_SOMITE_DEVELOPMENT","pval":0.58471,"padj":0.94167,"ES":-0.51442,"NES":-0.91589,"nMoreExtreme":15050,"size":70,"leadingEdge":["PLXNA2","XRCC2","DLL1","KAT2A"]} {"pathway":"GO_REGULATION_OF_FERTILIZATION","pval":0.65362,"padj":0.94878,"ES":-0.69726,"NES":-0.91681,"nMoreExtreme":27295,"size":13,"leadingEdge":["PLB1"]} {"pathway":"GO_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING","pval":0.58865,"padj":0.94167,"ES":-0.50347,"NES":-0.91758,"nMoreExtreme":14195,"size":80,"leadingEdge":["EPHB3","NRP1","ANTXR1","MERTK","TYRO3","KIF14","MELTF","FZD7","RADIL","PARVB"]} {"pathway":"GO_SKELETAL_MUSCLE_FIBER_DIFFERENTIATION","pval":0.56533,"padj":0.93517,"ES":-0.62963,"NES":-0.91758,"nMoreExtreme":26620,"size":5,"leadingEdge":["RBM24"]} {"pathway":"GO_REGULATION_OF_HEAT_GENERATION","pval":0.66505,"padj":0.94905,"ES":-0.6921,"NES":-0.9176,"nMoreExtreme":28966,"size":10,"leadingEdge":["TNFRSF11A","TNFSF11"]} {"pathway":"GO_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER","pval":0.69035,"padj":0.94995,"ES":-0.45395,"NES":-0.91794,"nMoreExtreme":10524,"size":163,"leadingEdge":["E2F2","CDK1","MAML3","NOTCH3","RUNX2"]} {"pathway":"GO_BLASTOCYST_DEVELOPMENT","pval":0.59319,"padj":0.94378,"ES":-0.49845,"NES":-0.91796,"nMoreExtreme":13898,"size":85,"leadingEdge":["PLPP4","NCAPG2","SOX17","GINS1","ASF1B","NEK2","ETV2","GINS4"]} {"pathway":"GO_REGULATION_OF_PEPTIDYL_CYSTEINE_S_NITROSYLATION","pval":0.63377,"padj":0.94878,"ES":-0.6641,"NES":-0.91827,"nMoreExtreme":28928,"size":7,"leadingEdge":["ACE"]} {"pathway":"GO_REGULATION_OF_CIRCADIAN_RHYTHM","pval":0.58338,"padj":0.94167,"ES":-0.5065,"NES":-0.91916,"nMoreExtreme":14272,"size":78,"leadingEdge":["TOP2A","GHRL","ADCY1","SUV39H2","PHLPP1"]} {"pathway":"GO_CHONDROITIN_SULFATE_BIOSYNTHETIC_PROCESS","pval":0.57488,"padj":0.94138,"ES":-0.65172,"NES":-0.91963,"nMoreExtreme":21080,"size":24,"leadingEdge":["XYLT1","VCAN","CHST13","CHST7"]} {"pathway":"GO_REGULATION_OF_GENE_EXPRESSION_BY_GENETIC_IMPRINTING","pval":0.63343,"padj":0.94878,"ES":-0.69608,"NES":-0.91982,"nMoreExtreme":25703,"size":15,"leadingEdge":["BRCA1"]} {"pathway":"GO_PYRIMIDINE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS","pval":0.55264,"padj":0.93341,"ES":-0.57747,"NES":-0.91991,"nMoreExtreme":17494,"size":41,"leadingEdge":["LCLAT1","TYMS","SHMT1","DUT"]} {"pathway":"GO_CHROMATIN_ORGANIZATION_INVOLVED_IN_REGULATION_OF_TRANSCRIPTION","pval":0.58209,"padj":0.94167,"ES":-0.50951,"NES":-0.92041,"nMoreExtreme":14415,"size":76,"leadingEdge":["CDC45","HELLS","ATAD2","CHEK1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MICROTUBULE_POLYMERIZATION","pval":0.65533,"padj":0.94878,"ES":-0.70158,"NES":-0.92258,"nMoreExtreme":27732,"size":12,"leadingEdge":["STMN1"]} {"pathway":"GO_PROTEIN_CONTAINING_COMPLEX_LOCALIZATION","pval":0.79582,"padj":0.96646,"ES":-0.43381,"NES":-0.923,"nMoreExtreme":7576,"size":262,"leadingEdge":["IFT122","BIRC5","DNM1","WDR34","HASPIN","SGCD","HIP1","LRRC7","IFT172","CEP72","NXF3","DYNC2H1"]} {"pathway":"GO_COCHLEA_DEVELOPMENT","pval":0.54657,"padj":0.93112,"ES":-0.60103,"NES":-0.92347,"nMoreExtreme":18227,"size":35,"leadingEdge":["MCM2","CCNA2","SOBP"]} {"pathway":"GO_TOR_SIGNALING","pval":0.60416,"padj":0.94684,"ES":-0.48089,"NES":-0.92379,"nMoreExtreme":12130,"size":111,"leadingEdge":["DEPTOR","CASTOR1","SESN3","SESN1","DDIT4","TREM2","FAM83D","RNF152"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_LEPTIN_STIMULUS","pval":0.64869,"padj":0.94878,"ES":-0.70259,"NES":-0.92382,"nMoreExtreme":27089,"size":13,"leadingEdge":["PID1","CCNA2"]} {"pathway":"GO_PURINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS","pval":0.66938,"padj":0.94905,"ES":-0.45619,"NES":-0.92429,"nMoreExtreme":9948,"size":167,"leadingEdge":["PID1","PDK4","AK1","PRTFDC1","ADCY1","SHMT1","ADCY4","TREM2","GUCY1A2"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_CALCIUM_ION","pval":0.56018,"padj":0.93517,"ES":-0.52618,"NES":-0.92453,"nMoreExtreme":14911,"size":65,"leadingEdge":["SYT1","SYT6","CRHBP","CPNE5","ADCY1","ALOX15","RYR1","FOS","RASAL1"]} {"pathway":"GO_HISTONE_PHOSPHORYLATION","pval":0.54468,"padj":0.93088,"ES":-0.60185,"NES":-0.92474,"nMoreExtreme":18164,"size":35,"leadingEdge":["CDK1","CCNA2","AURKB","HASPIN","PRKCA","CHEK1"]} {"pathway":"GO_EOSINOPHIL_DIFFERENTIATION","pval":0.50345,"padj":0.91988,"ES":-0.60133,"NES":-0.92559,"nMoreExtreme":25048,"size":2,"leadingEdge":["GATA2","TRIB1"]} {"pathway":"GO_REGULATION_OF_AXON_GUIDANCE","pval":0.54286,"padj":0.93003,"ES":-0.59476,"NES":-0.92598,"nMoreExtreme":17768,"size":37,"leadingEdge":["NRP1","SEMA6B","SEMA3G","SEMA6C","SEMA4C"]} {"pathway":"GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS_VIA_SOMATIC_MUTATION","pval":0.64713,"padj":0.94878,"ES":-0.70436,"NES":-0.92615,"nMoreExtreme":27024,"size":13,"leadingEdge":["EXO1","UNG","POLQ"]} {"pathway":"GO_RENAL_SYSTEM_VASCULATURE_DEVELOPMENT","pval":0.56504,"padj":0.93517,"ES":-0.65704,"NES":-0.92713,"nMoreExtreme":20719,"size":24,"leadingEdge":["NRP1","NOTCH3","BMP4"]} {"pathway":"GO_AORTA_MORPHOGENESIS","pval":0.55698,"padj":0.93517,"ES":-0.64603,"NES":-0.92736,"nMoreExtreme":20061,"size":26,"leadingEdge":["HEY1","ENG"]} {"pathway":"GO_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY","pval":0.53937,"padj":0.92859,"ES":-0.56242,"NES":-0.92742,"nMoreExtreme":16173,"size":48,"leadingEdge":["LBH","BRCA1","KANK2","DNAAF4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CYTOPLASMIC_TRANSPORT","pval":0.64536,"padj":0.94878,"ES":-0.7059,"NES":-0.92817,"nMoreExtreme":26950,"size":13,"leadingEdge":["DAB2","SORL1","PRKN"]} {"pathway":"GO_HYPOTHALAMUS_DEVELOPMENT","pval":0.65075,"padj":0.94878,"ES":-0.70661,"NES":-0.92918,"nMoreExtreme":27538,"size":12,"leadingEdge":["NRP1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SMAD_PROTEIN_SIGNAL_TRANSDUCTION","pval":0.65643,"padj":0.94878,"ES":-0.70711,"NES":-0.93079,"nMoreExtreme":28161,"size":11,"leadingEdge":["DAB2","BMP6","BMP4"]} {"pathway":"GO_MITOTIC_SPINDLE_MIDZONE_ASSEMBLY","pval":0.5627,"padj":0.93517,"ES":-0.63902,"NES":-0.93126,"nMoreExtreme":26496,"size":5,"leadingEdge":["AURKB","KIF4A","RACGAP1"]} {"pathway":"GO_DEPHOSPHORYLATION","pval":0.90282,"padj":0.98417,"ES":-0.42295,"NES":-0.93188,"nMoreExtreme":4542,"size":406,"leadingEdge":["G6PC","CDC25A","PLPP4","PKMYT1","NT5DC2","CDC25C","NUAK1","INPP4B","DUSP27","KNL1","CTDSPL","DLGAP5","INPP5A","BCL2","PTPN14","PHLPP1","CDCA2","IGFBP3","IMPA2","CDKN3","PTPN13","PPM1L","CSRNP3","MYO1D","SLC7A14","PALD1"]} {"pathway":"GO_REGULATION_OF_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY","pval":0.62961,"padj":0.94878,"ES":-0.67448,"NES":-0.93262,"nMoreExtreme":28738,"size":7,"leadingEdge":["STMN1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TELOMERE_MAINTENANCE","pval":0.52888,"padj":0.92669,"ES":-0.56352,"NES":-0.93336,"nMoreExtreme":15777,"size":49,"leadingEdge":["PKIB","AURKB","NEK2"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_CARBOHYDRATE_STIMULUS","pval":0.58027,"padj":0.94163,"ES":-0.4841,"NES":-0.93344,"nMoreExtreme":11428,"size":114,"leadingEdge":["COLEC12","GHRL","LRP5","SLC2A5","MAP2K6","MAPK13","TIAM1","CALCRL"]} {"pathway":"GO_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION","pval":0.66359,"padj":0.94905,"ES":-0.45033,"NES":-0.93391,"nMoreExtreme":8329,"size":204,"leadingEdge":["CDC25A","CDC6","CLSPN","TICRR","RECQL4","CDK1","BRCA1","DTL","ORC1","GTSE1","AURKB","CENPF","CDC25C","KIF14","PLK4","CHEK1","NEK2","TPX2","FBXO5","BLM","PLK1","NEK10"]} {"pathway":"GO_RETINAL_GANGLION_CELL_AXON_GUIDANCE","pval":0.61261,"padj":0.94703,"ES":-0.70338,"NES":-0.93441,"nMoreExtreme":24564,"size":16,"leadingEdge":["EPHB3","NRP1"]} {"pathway":"GO_DNA_DOUBLE_STRAND_BREAK_PROCESSING","pval":0.56048,"padj":0.93517,"ES":-0.66807,"NES":-0.93505,"nMoreExtreme":20784,"size":23,"leadingEdge":["BRCA1","DNA2","BLM"]} {"pathway":"GO_NOTOCHORD_DEVELOPMENT","pval":0.62017,"padj":0.94878,"ES":-0.70803,"NES":-0.9356,"nMoreExtreme":25165,"size":15,"leadingEdge":["STIL","ID3"]} {"pathway":"GO_GLOMERULUS_DEVELOPMENT","pval":0.52336,"padj":0.92646,"ES":-0.56265,"NES":-0.93616,"nMoreExtreme":15523,"size":50,"leadingEdge":["MTSS1","NOTCH3","BCL2","LGR4","COL4A4","BMP4","CD24"]} {"pathway":"GO_TEMPERATURE_HOMEOSTASIS","pval":0.59213,"padj":0.94373,"ES":-0.47319,"NES":-0.93625,"nMoreExtreme":10302,"size":137,"leadingEdge":["TNFRSF11A","GHRL","EPAS1","G0S2","APPL2","PDGFC","TNFSF11","MAP2K6","ADAMTS5","HADH","PRLR","ADRB1","GPR3","LGR4","NTSR1","ACOT11","GATM","NOVA1","CCR2"]} {"pathway":"GO_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY","pval":0.52772,"padj":0.92669,"ES":-0.59127,"NES":-0.93637,"nMoreExtreme":16800,"size":40,"leadingEdge":["TESC","SCN4B","FXYD2","SLC9A3R1"]} {"pathway":"GO_VESTIBULOCOCHLEAR_NERVE_DEVELOPMENT","pval":0.51124,"padj":0.92419,"ES":-0.62255,"NES":-0.93664,"nMoreExtreme":24516,"size":4,"leadingEdge":["NRP1"]} {"pathway":"GO_VESTIBULOCOCHLEAR_NERVE_MORPHOGENESIS","pval":0.51124,"padj":0.92419,"ES":-0.62255,"NES":-0.93664,"nMoreExtreme":24516,"size":4,"leadingEdge":["NRP1"]} {"pathway":"GO_REGULATION_OF_EXTENT_OF_CELL_GROWTH","pval":0.55162,"padj":0.93273,"ES":-0.49956,"NES":-0.9372,"nMoreExtreme":12182,"size":95,"leadingEdge":["NRP1","SEMA6B","FSTL4","SEMA3G","SEMA6C","CDK5R1","SEMA4C"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS","pval":0.62864,"padj":0.94878,"ES":-0.71175,"NES":-0.93726,"nMoreExtreme":25862,"size":14,"leadingEdge":["ADAM8"]} {"pathway":"GO_PLACENTA_BLOOD_VESSEL_DEVELOPMENT","pval":0.53565,"padj":0.92816,"ES":-0.64163,"NES":-0.93744,"nMoreExtreme":18963,"size":28,"leadingEdge":["PLCD3","HEY1"]} {"pathway":"GO_REGULATION_OF_METALLOPEPTIDASE_ACTIVITY","pval":0.64456,"padj":0.94878,"ES":-0.71302,"NES":-0.93762,"nMoreExtreme":27276,"size":12,"leadingEdge":["ANTXR1","SORL1"]} {"pathway":"GO_EMBRYONIC_PLACENTA_DEVELOPMENT","pval":0.53844,"padj":0.92855,"ES":-0.52053,"NES":-0.93825,"nMoreExtreme":13412,"size":75,"leadingEdge":["PCDH12","E2F8","EPAS1","PLCD3","E2F7","PLK4","SNAI1","HEY1"]} {"pathway":"GO_OSTEOBLAST_PROLIFERATION","pval":0.56182,"padj":0.93517,"ES":-0.67578,"NES":-0.9384,"nMoreExtreme":21028,"size":22,"leadingEdge":["TMEM119","BCL2"]} {"pathway":"GO_ACTIN_FILAMENT_BUNDLE_ORGANIZATION","pval":0.58258,"padj":0.94167,"ES":-0.4751,"NES":-0.93844,"nMoreExtreme":10246,"size":135,"leadingEdge":["S1PR1","NRP1","STMN1","FSCN1","PXN","ITGB5","RFLNB","LIMCH1","BAIAP2","FHOD1","ARHGAP6","SHROOM1"]} {"pathway":"GO_REGULATION_OF_ANOIKIS","pval":0.57569,"padj":0.94161,"ES":-0.6875,"NES":-0.9385,"nMoreExtreme":21983,"size":20,"leadingEdge":["PDK4","BCL2"]} {"pathway":"GO_PHOSPHATIDYLGLYCEROL_METABOLIC_PROCESS","pval":0.6275,"padj":0.94878,"ES":-0.71279,"NES":-0.93863,"nMoreExtreme":25815,"size":14,"leadingEdge":["LCLAT1","PLA2G4B"]} {"pathway":"GO_SIGNAL_TRANSDUCTION_IN_RESPONSE_TO_DNA_DAMAGE","pval":0.57731,"padj":0.94163,"ES":-0.47927,"NES":-0.93887,"nMoreExtreme":10618,"size":127,"leadingEdge":["E2F8","E2F1","CDK1","BRCA1","DTL","GTSE1","CDC25C","E2F7","FOXM1","CHEK1","PLK1","SNAI1","PCNA","ATAD5","TFAP4","CDK2","FOXO3"]} {"pathway":"GO_UROGENITAL_SYSTEM_DEVELOPMENT","pval":0.71037,"padj":0.95214,"ES":-0.43857,"NES":-0.93922,"nMoreExtreme":6197,"size":282,"leadingEdge":["MTSS1","EPHB3","PKD1L3","NRP1","MMP9","SGPL1","SOX17","DLL1","CENPF","KANK2","TP73","HPGD","NFIA","NOTCH3","ACE","BCL2","GLIS2","IRX3","CEP55","LGR4","KIF26B","CYP19A1","RBP4","CAT","FGFR1","COL4A4","BMP6","BMP4","ID3","CD24","GREB1L"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT","pval":0.52375,"padj":0.92669,"ES":-0.54723,"NES":-0.93944,"nMoreExtreme":14653,"size":58,"leadingEdge":["CDK1","SOX17","DLL1","PARP2","BCL2","AKAP6","TGFBR3","FGFR1","KAT2A","RBM24","BMP4"]} {"pathway":"GO_POSTREPLICATION_REPAIR","pval":0.51768,"padj":0.92515,"ES":-0.56256,"NES":-0.93952,"nMoreExtreme":15196,"size":51,"leadingEdge":["PCLAF","BRCA1","DTL","POLE2","RFC3","RFC5","RFC4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY","pval":0.52607,"padj":0.92669,"ES":-0.62406,"NES":-0.93985,"nMoreExtreme":18011,"size":32,"leadingEdge":["E2F1","TP73","BCL2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION","pval":0.65317,"padj":0.94878,"ES":-0.44879,"NES":-0.94002,"nMoreExtreme":7468,"size":223,"leadingEdge":["E2F8","E2F1","CDKN2C","CDC6","CLSPN","TICRR","CDT1","CDK1","BRCA1","DTL","MAD2L1","ORC1","GTSE1","NDC80","AURKB","BUB1B","CENPF","WEE1","CDC25C","KANK2","TTK","E2F7","JADE1","CTDSPL","CHEK1","FBXO5","BCL2","BUB1","CDC20","TRIP13","BLM","PLK1","CDKN2B"]} {"pathway":"GO_RHO_PROTEIN_SIGNAL_TRANSDUCTION","pval":0.61385,"padj":0.94703,"ES":-0.45968,"NES":-0.94014,"nMoreExtreme":8607,"size":180,"leadingEdge":["NRP1","F2RL3","FGD5","ITSN1","CELSR1","MCF2L","STMN1","ARHGEF39","KANK2","ADGRG1","PLEKHG5","CTNNAL1","TIAM1","ARHGAP6","DNMBP","ARHGEF16","FGD1","NGEF"]} {"pathway":"GO_THYROID_HORMONE_TRANSPORT","pval":0.47178,"padj":0.90882,"ES":-0.6093,"NES":-0.94033,"nMoreExtreme":23060,"size":3,"leadingEdge":["SLC16A10"]} {"pathway":"GO_POSITIVE_REGULATION_OF_HEAT_GENERATION","pval":0.64367,"padj":0.94878,"ES":-0.69211,"NES":-0.94035,"nMoreExtreme":28901,"size":8,"leadingEdge":["TNFRSF11A","TNFSF11"]} {"pathway":"GO_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION","pval":0.51791,"padj":0.92529,"ES":-0.58763,"NES":-0.9407,"nMoreExtreme":16276,"size":42,"leadingEdge":["MAF","RFLNB","RUNX2","BMP6","BMP4"]} {"pathway":"GO_CELL_MORPHOGENESIS_INVOLVED_IN_NEURON_DIFFERENTIATION","pval":0.89666,"padj":0.98354,"ES":-0.42216,"NES":-0.94087,"nMoreExtreme":3305,"size":485,"leadingEdge":["EPHB3","NRP1","SEMA6B","FSTL4","PLXNA2","SDC2","GFRA2","DAB1","STMN1","PRKCA","FZD3","MYO7A","ADCY1","BAIAP2","SHC3","BCL2","SEMA3G","NECTIN1","SEMA6C","GDF7","TIAM1","CDK5R1","FLRT3","UST","ITPKA","CUX2","SEMA4C","UNC5B","SLC9A3R1","EFNB1","CELSR2","NGEF","IRS2","ETV1"]} {"pathway":"GO_OUTER_EAR_MORPHOGENESIS","pval":0.65175,"padj":0.94878,"ES":-0.70241,"NES":-0.94088,"nMoreExtreme":28753,"size":9,"leadingEdge":["FGFR1"]} {"pathway":"GO_REGULATION_OF_MEIOTIC_CELL_CYCLE","pval":0.52079,"padj":0.9256,"ES":-0.60825,"NES":-0.94097,"nMoreExtreme":17192,"size":36,"leadingEdge":["CDC25A","PDE3A","CDC25C","TTK","INSR","ASPM","FBXO5","CDC20","TRIP13","FBXO43","GPR3","PRKACB"]} {"pathway":"GO_CILIUM_OR_FLAGELLUM_DEPENDENT_CELL_MOTILITY","pval":0.57239,"padj":0.94008,"ES":-0.68953,"NES":-0.94127,"nMoreExtreme":21857,"size":20,"leadingEdge":["CFAP44","DNAH17"]} {"pathway":"GO_CALCIUM_ION_REGULATED_EXOCYTOSIS_OF_NEUROTRANSMITTER","pval":0.62526,"padj":0.94878,"ES":-0.71495,"NES":-0.94147,"nMoreExtreme":25723,"size":14,"leadingEdge":["SYT1"]} {"pathway":"GO_SYNAPSIS","pval":0.54783,"padj":0.93115,"ES":-0.66728,"NES":-0.94158,"nMoreExtreme":20088,"size":24,"leadingEdge":["CCNE2","DMC1","TRIP13","CCNE1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_CELL_PROLIFERATION","pval":0.65004,"padj":0.94878,"ES":-0.71544,"NES":-0.94176,"nMoreExtreme":27887,"size":11,"leadingEdge":["GHRL","FGFR1"]} {"pathway":"GO_CELLULAR_HORMONE_METABOLIC_PROCESS","pval":0.5193,"padj":0.92533,"ES":-0.54505,"NES":-0.94189,"nMoreExtreme":14288,"size":60,"leadingEdge":["PLB1","DHRS3","SGPL1","SULT1E1","RBP4","BMP6"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY_INVOLVED_IN_DORSAL_VENTRAL_NEURAL_TUBE_PATTERNING","pval":0.59885,"padj":0.94562,"ES":-0.66563,"NES":-0.94257,"nMoreExtreme":27745,"size":6,"leadingEdge":["PRKACB"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_AXON_GUIDANCE","pval":0.53516,"padj":0.92816,"ES":-0.65738,"NES":-0.94364,"nMoreExtreme":19275,"size":26,"leadingEdge":["NRP1","SEMA6B","SEMA3G","SEMA6C","SEMA4C"]} {"pathway":"GO_REGULATION_OF_CELLULAR_CARBOHYDRATE_METABOLIC_PROCESS","pval":0.53411,"padj":0.92816,"ES":-0.50493,"NES":-0.94374,"nMoreExtreme":11922,"size":93,"leadingEdge":["PDK4","SLC45A3","INSR","KHK","PASK","DDIT4","IGFBP3","HRH1","NTSR1","C1QTNF3","IRS2","PPP1R3G","PRKN"]} {"pathway":"GO_REGULATION_OF_SMAD_PROTEIN_SIGNAL_TRANSDUCTION","pval":0.59322,"padj":0.94378,"ES":-0.70709,"NES":-0.94513,"nMoreExtreme":23474,"size":17,"leadingEdge":["DAB2","BMP6","BMP4"]} {"pathway":"GO_HEART_GROWTH","pval":0.52399,"padj":0.92669,"ES":-0.52447,"NES":-0.94536,"nMoreExtreme":13052,"size":75,"leadingEdge":["S1PR1","CDK1","CXADR","TP73","PARP2","AKAP6","TGFBR3","RBP4","FGFR1","JARID2"]} {"pathway":"GO_REGIONALIZATION","pval":0.63635,"padj":0.94878,"ES":-0.44777,"NES":-0.94581,"nMoreExtreme":6605,"size":244,"leadingEdge":["NRP1","SSBP3","PLXNA2","IFT122","LRP5","XRCC2","CELSR1","SOX17","DLL1","ADGRG1","DLX1","MNS1","IRX3","SNAI1","PRKACB","WLS","IFT172","PCSK6","DISP1","FGFR1","KAT2A","CELSR2","GREM2","SKI"]} {"pathway":"GO_CARDIAC_CHAMBER_MORPHOGENESIS","pval":0.53819,"padj":0.92855,"ES":-0.49796,"NES":-0.94629,"nMoreExtreme":11196,"size":104,"leadingEdge":["NRP1","DHRS3","TGFBR3","HEY1","RBP4","TNNC1","BMP4","GJA5","ENG"]} {"pathway":"GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY","pval":0.65082,"padj":0.94878,"ES":-0.445,"NES":-0.94635,"nMoreExtreme":6271,"size":260,"leadingEdge":["DAB2","CDH5","APPL2","HTRA1","PXN","ITGB5","TTK","HPGD","HTRA3","DLX1","ATOH8","TGFBR3","LDLRAD4","GDF7","CDKN2B","RUNX2","PCSK6","THBS1","ETV2","PPM1L","BMP6","GREM2","CD109","SKI","BMP8A","BMP4","FOS","ENG"]} {"pathway":"GO_SENSORY_PERCEPTION_OF_SMELL","pval":0.51205,"padj":0.92419,"ES":-0.60157,"NES":-0.94694,"nMoreExtreme":16425,"size":39,"leadingEdge":["OR7A17","OR6J1"]} {"pathway":"GO_RESPONSE_TO_RADIATION","pval":0.70605,"padj":0.9508,"ES":-0.43473,"NES":-0.94837,"nMoreExtreme":4248,"size":360,"leadingEdge":["TNFRSF11A","THBD","CDC25A","RAD54L","PCLAF","TICRR","FEN1","XRCC2","HRH2","BRCA1","DTL","AURKB","RAD51","FANCG","MAPK13","CHEK1","BCL2","PBK","RRM1","BLM","HRH1","BACE1","RAD51AP1","TP53INP1","CAT"]} {"pathway":"GO_GLIAL_CELL_DIFFERENTIATION","pval":0.57446,"padj":0.94135,"ES":-0.4651,"NES":-0.94875,"nMoreExtreme":8304,"size":175,"leadingEdge":["CDKN2C","TAL1","TNFRSF21","OLIG1","CDK1","SLC45A3","DAB1","DLL1","TP73","CD9","OLIG2","DLX1","DNER","TREM2","SH3TC2","C5AR1","SKI"]} {"pathway":"GO_MOLTING_CYCLE","pval":0.51591,"padj":0.92482,"ES":-0.52528,"NES":-0.9489,"nMoreExtreme":12776,"size":76,"leadingEdge":["EDA","CELSR1","FZD3","BCL2","SNAI1","LGR4","FOXE1","CD109","MYO5A","WNT10B"]} {"pathway":"GO_CARDIAC_MUSCLE_CELL_PROLIFERATION","pval":0.50256,"padj":0.91978,"ES":-0.58795,"NES":-0.95008,"nMoreExtreme":15485,"size":44,"leadingEdge":["CDK1","CXADR","TP73","TGFBR3","RBP4","FGFR1","JARID2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION","pval":0.64512,"padj":0.94878,"ES":-0.72235,"NES":-0.95085,"nMoreExtreme":27676,"size":11,"leadingEdge":["ANTXR1","ADTRP"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ANOIKIS","pval":0.61807,"padj":0.94878,"ES":-0.72282,"NES":-0.95184,"nMoreExtreme":25427,"size":14,"leadingEdge":["PDK4","BCL2"]} {"pathway":"GO_CARDIAC_SEPTUM_DEVELOPMENT","pval":0.51458,"padj":0.92459,"ES":-0.50752,"NES":-0.95213,"nMoreExtreme":11364,"size":95,"leadingEdge":["NRP1","DHRS3","TGFBR3","HEY1","BMP4","GJA5","ENG","PLXND1"]} {"pathway":"GO_EXTRACELLULAR_MATRIX_DISASSEMBLY","pval":0.49934,"padj":0.91927,"ES":-0.54927,"NES":-0.95253,"nMoreExtreme":13644,"size":61,"leadingEdge":["ADAM8","MMP9","HTRA1","FSCN1","MELTF","ADAMTS5","KIF9","MMP8"]} {"pathway":"GO_NEURON_FATE_COMMITMENT","pval":0.50139,"padj":0.91978,"ES":-0.60962,"NES":-0.9541,"nMoreExtreme":16236,"size":38,"leadingEdge":["OLIG1","DLL1","OLIG2","NOTCH3","DLX1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT","pval":0.71096,"padj":0.95246,"ES":-0.43106,"NES":-0.95498,"nMoreExtreme":3236,"size":433,"leadingEdge":["CX3CR1","SYT1","EPHB3","NRP1","E2F1","GHRL","PLXNA2","THBS2","XRCC2","MMD","DAB1","TP73","FZD3","CPNE5","SYNDIG1","ASPM","OLIG2","BCL2","DLX1","CDC20","SRPX2","ADRA2B","ENC1","IRX3","MYB","GDF7","TIAM1","TREM2","FLRT3","LRRC7","LRRN1","ITPKA","CUX2","FGFR1","CCR2","CAMK1","BMP6","LRRTM1"]} {"pathway":"GO_CORTICOSTERONE_SECRETION","pval":0.56769,"padj":0.93692,"ES":-0.71705,"NES":-0.95538,"nMoreExtreme":28363,"size":1,"leadingEdge":["SELENOM"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY","pval":0.51538,"padj":0.92459,"ES":-0.49307,"NES":-0.95578,"nMoreExtreme":9949,"size":118,"leadingEdge":["CDKN2C","PKIB","LRP5","INKA1","PLK1","SORL1","CDKN2B","INKA2"]} {"pathway":"GO_CARBOHYDRATE_HOMEOSTASIS","pval":0.54866,"padj":0.93125,"ES":-0.46795,"NES":-0.95624,"nMoreExtreme":7728,"size":179,"leadingEdge":["G6PC","PDK4","GHRL","LRP5","SESN3","APPL2","INSR","TIAM1","ACSM2A","RBP4","IRS2","PPP1R3G","FOXO3","NMB","GPR27"]} {"pathway":"GO_MULTINUCLEAR_OSTEOCLAST_DIFFERENTIATION","pval":0.62327,"padj":0.94878,"ES":-0.69199,"NES":-0.95684,"nMoreExtreme":28449,"size":7,"leadingEdge":["TNFRSF11A","SH3PXD2A"]} {"pathway":"GO_DITERPENOID_METABOLIC_PROCESS","pval":0.48803,"padj":0.91689,"ES":-0.56851,"NES":-0.95697,"nMoreExtreme":14150,"size":53,"leadingEdge":["PLB1","DHRS3","SDC2","LPL","RBP1","RBP4"]} {"pathway":"GO_REGULATION_OF_FEVER_GENERATION","pval":0.62323,"padj":0.94878,"ES":-0.69211,"NES":-0.957,"nMoreExtreme":28447,"size":7,"leadingEdge":["TNFRSF11A","TNFSF11"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ERBB_SIGNALING_PATHWAY","pval":0.48944,"padj":0.91689,"ES":-0.58668,"NES":-0.95793,"nMoreExtreme":14877,"size":46,"leadingEdge":["HBEGF"]} {"pathway":"GO_REGULATION_OF_REPRODUCTIVE_PROCESS","pval":0.5057,"padj":0.92004,"ES":-0.50463,"NES":-0.95795,"nMoreExtreme":10599,"size":103,"leadingEdge":["CDC25A","PLB1","PDE3A","CDC25C","TTK","INSR","ASPM","FBXO5","CDC20","TRIP13","FBXO43","SNAI1","GPR3","PRKACB","RETN"]} {"pathway":"GO_EMBRYONIC_HEART_TUBE_DEVELOPMENT","pval":0.48541,"padj":0.91689,"ES":-0.56447,"NES":-0.95866,"nMoreExtreme":13887,"size":55,"leadingEdge":["IFT122","MICAL2","SOX17","DLL1","IFT172","STIL","GJA5","ENG"]} {"pathway":"GO_REGULATION_OF_MAMMARY_GLAND_EPITHELIAL_CELL_PROLIFERATION","pval":0.59144,"padj":0.94324,"ES":-0.72166,"NES":-0.9587,"nMoreExtreme":23715,"size":16,"leadingEdge":["IQGAP3"]} {"pathway":"GO_CELL_PART_MORPHOGENESIS","pval":0.75907,"padj":0.9603,"ES":-0.42616,"NES":-0.95879,"nMoreExtreme":2050,"size":565,"leadingEdge":["PID1","SYT1","EPHB3","NRP1","SEMA6B","FSTL4","PLXNA2","SDC2","GFRA2","DAB1","STMN1","WEE1","PRKCA","FZD3","CPNE5","ADCY1","BAIAP2","SHC3","BCL2","SEMA3G","NECTIN1","SEMA6C","GDF7","TIAM1","CDK5R1","FLRT3","UST","ITPKA","CUX2","SEMA4C","UNC5B","NES","EFNB1","CELSR2","NGEF","IRS2","ETV1","KIF20B","RAPH1","PRKN","FEZ1","RASAL1","PLXND1","DNM3","HECW1","PTPRZ1"]} {"pathway":"GO_DEVELOPMENTAL_CELL_GROWTH","pval":0.53903,"padj":0.92855,"ES":-0.46682,"NES":-0.95882,"nMoreExtreme":7353,"size":186,"leadingEdge":["SYT1","NRP1","SEMA6B","FSTL4","CPNE5","PARP2","AKAP6","SEMA3G","SEMA6C","TIAM1","CDK5R1","FLRT3","SEMA4C"]} {"pathway":"GO_CHONDROITIN_SULFATE_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS","pval":0.50524,"padj":0.91988,"ES":-0.65171,"NES":-0.95915,"nMoreExtreme":17737,"size":29,"leadingEdge":["XYLT1","VCAN","CHST13","CHST7"]} {"pathway":"GO_EMBRYONIC_SKELETAL_SYSTEM_DEVELOPMENT","pval":0.49465,"padj":0.91907,"ES":-0.51387,"NES":-0.96044,"nMoreExtreme":11041,"size":93,"leadingEdge":["XYLT1","DLX1","TBX15","RBP4","RUNX2","BMP4"]} {"pathway":"GO_CELL_SUBSTRATE_JUNCTION_ASSEMBLY","pval":0.49259,"padj":0.91907,"ES":-0.51654,"NES":-0.96068,"nMoreExtreme":11237,"size":90,"leadingEdge":["NRP1","LAMB3","LIMCH1","BCL2","ARHGAP6","THBS1"]} {"pathway":"GO_GANGLION_DEVELOPMENT","pval":0.62995,"padj":0.94878,"ES":-0.73131,"NES":-0.96167,"nMoreExtreme":26658,"size":12,"leadingEdge":["NRP1","FZD3"]} {"pathway":"GO_CELL_CELL_ADHESION_MEDIATED_BY_CADHERIN","pval":0.50142,"padj":0.91978,"ES":-0.65348,"NES":-0.96174,"nMoreExtreme":17603,"size":29,"leadingEdge":["CDH5","NEXMIF","CDH26"]} {"pathway":"GO_CELL_CYCLE_G2_M_PHASE_TRANSITION","pval":0.56163,"padj":0.93517,"ES":-0.45334,"NES":-0.9632,"nMoreExtreme":5476,"size":257,"leadingEdge":["CDC25A","CDC6","CLSPN","TICRR","RECQL4","PKMYT1","CDK1","BRCA1","DTL","CCNA2","ORC1","GTSE1","AURKB","CENPF","WEE1","CDC25C","CIT","KIF14","FOXM1","PLK4","CCNB2","CHEK1","NEK2","TPX2","FBXO5","BLM","PLK1","NEK10","CDKN2B","NES","HMMR","CEP72","DONSON","TPD52L1","ATAD5","CDC7"]} {"pathway":"GO_LUTEINIZATION","pval":0.63538,"padj":0.94878,"ES":-0.70927,"NES":-0.96367,"nMoreExtreme":28529,"size":8,"leadingEdge":["SGPL1","RETN"]} {"pathway":"GO_MITOTIC_DNA_REPLICATION","pval":0.63785,"padj":0.94878,"ES":-0.73215,"NES":-0.96375,"nMoreExtreme":27364,"size":11,"leadingEdge":["CDC45","GINS1","RAD51","POLA1","FGFR1"]} {"pathway":"GO_REGULATION_OF_ACTOMYOSIN_STRUCTURE_ORGANIZATION","pval":0.4818,"padj":0.91676,"ES":-0.52906,"NES":-0.96422,"nMoreExtreme":11618,"size":80,"leadingEdge":["S1PR1","NRP1","STMN1","PXN","LIMCH1","FHOD1","ARHGAP6"]} {"pathway":"GO_PALLIUM_DEVELOPMENT","pval":0.49823,"padj":0.91907,"ES":-0.48673,"NES":-0.96474,"nMoreExtreme":8584,"size":139,"leadingEdge":["NRP1","DAB1","TACC2","WDR62","ADGRG1","KIF14","ASPM","DLX1","CDK5R1","TACC3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CHROMOSOME_ORGANIZATION","pval":0.50134,"padj":0.91978,"ES":-0.48012,"NES":-0.96515,"nMoreExtreme":7871,"size":156,"leadingEdge":["TAL1","PKIB","CDT1","FEN1","BRCA1","AURKB","ESPL1","DLGAP5","NEK2","SLF1","MYB","LMNA","KAT2A","DDX11","JARID2"]} {"pathway":"GO_REGULATION_OF_DNA_TOPOISOMERASE_ATP_HYDROLYZING_ACTIVITY","pval":0.59367,"padj":0.94378,"ES":-0.6817,"NES":-0.96533,"nMoreExtreme":27505,"size":6,"leadingEdge":["UHRF1","NCAPH"]} {"pathway":"GO_MICROTUBULE_POLYMERIZATION","pval":0.47529,"padj":0.91084,"ES":-0.54697,"NES":-0.96592,"nMoreExtreme":12471,"size":67,"leadingEdge":["STMN1","FBXO5","CDK5R1"]} {"pathway":"GO_ICOSANOID_CATABOLIC_PROCESS","pval":0.54918,"padj":0.93134,"ES":-0.72581,"NES":-0.96706,"nMoreExtreme":27438,"size":1,"leadingEdge":["ABHD16A"]} {"pathway":"GO_RETINA_MORPHOGENESIS_IN_CAMERA_TYPE_EYE","pval":0.48737,"padj":0.91689,"ES":-0.64245,"NES":-0.96754,"nMoreExtreme":16686,"size":32,"leadingEdge":["LRP5","DLL1","RBP4","THRB"]} {"pathway":"GO_SEX_DIFFERENTIATION","pval":0.50942,"padj":0.92379,"ES":-0.4681,"NES":-0.96805,"nMoreExtreme":6514,"size":199,"leadingEdge":["TESC","KITLG","DMC1","SGPL1","MERTK","TYRO3","CENPI","ADGRG1","INSR","MAMLD1","FANCG","ASPM","BCL2","HMGB2","RRM1","LGR4","DMRTA1","CYP19A1","RBP4","NUDT1","RETN","CBX2","BMP6","PTX3","GREB1L","MSH2","FOXO3","CNTFR"]} {"pathway":"GO_LEYDIG_CELL_DIFFERENTIATION","pval":0.63325,"padj":0.94878,"ES":-0.71326,"NES":-0.9691,"nMoreExtreme":28433,"size":8,"leadingEdge":["SGPL1"]} {"pathway":"GO_BICARBONATE_TRANSPORT","pval":0.5153,"padj":0.92459,"ES":-0.68721,"NES":-0.9697,"nMoreExtreme":18895,"size":24,"leadingEdge":["SLC4A7","SLC26A9"]} {"pathway":"GO_REGULATION_OF_MICROTUBULE_BASED_PROCESS","pval":0.50097,"padj":0.91978,"ES":-0.46928,"NES":-0.96972,"nMoreExtreme":6487,"size":197,"leadingEdge":["BRCA1","KIF11","STMN1","CCNF","SKA3","SPAG5","SKA1","PLK4","CHEK1","NEK2","TPX2","PLK1","CDK5R1","KIF25","XRCC3","TACC3","KAT2A"]} {"pathway":"GO_ESTROGEN_METABOLIC_PROCESS","pval":0.63447,"padj":0.94878,"ES":-0.73708,"NES":-0.97024,"nMoreExtreme":27219,"size":11,"leadingEdge":["SGPL1","SULT1E1"]} {"pathway":"GO_CDC42_PROTEIN_SIGNAL_TRANSDUCTION","pval":0.63821,"padj":0.94878,"ES":-0.73197,"NES":-0.97045,"nMoreExtreme":27797,"size":10,"leadingEdge":["NRP1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY","pval":0.63842,"padj":0.94878,"ES":-0.72455,"NES":-0.97054,"nMoreExtreme":28165,"size":9,"leadingEdge":["CCR2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_STEM_CELL_PROLIFERATION","pval":0.49891,"padj":0.91907,"ES":-0.67015,"NES":-0.97055,"nMoreExtreme":17811,"size":27,"leadingEdge":["CX3CR1","KITLG","FZD3","ASPM"]} {"pathway":"GO_ENDODERM_DEVELOPMENT","pval":0.4659,"padj":0.90672,"ES":-0.55633,"NES":-0.97068,"nMoreExtreme":12561,"size":63,"leadingEdge":["LAMB3","MMP9","SOX17","ITGB5","MMP8","BMP4"]} {"pathway":"GO_PTERIDINE_CONTAINING_COMPOUND_METABOLIC_PROCESS","pval":0.51995,"padj":0.9256,"ES":-0.69408,"NES":-0.97146,"nMoreExtreme":19281,"size":23,"leadingEdge":["TYMS","DHFR","SLC46A1","SHMT1"]} {"pathway":"GO_CELLULAR_CARBOHYDRATE_BIOSYNTHETIC_PROCESS","pval":0.46408,"padj":0.90533,"ES":-0.5487,"NES":-0.97179,"nMoreExtreme":12116,"size":68,"leadingEdge":["INSR","PASK","IMPA2","IRS2","PPP1R3G"]} {"pathway":"GO_FATTY_ACID_TRANSMEMBRANE_TRANSPORT","pval":0.56919,"padj":0.93876,"ES":-0.72708,"NES":-0.97185,"nMoreExtreme":22523,"size":17,"leadingEdge":["THBS1","IRS2"]} {"pathway":"GO_ADENOSINE_TO_INOSINE_EDITING","pval":0.63171,"padj":0.94878,"ES":-0.71647,"NES":-0.97345,"nMoreExtreme":28364,"size":8,"leadingEdge":["ADARB2"]} {"pathway":"GO_SPECIFICATION_OF_SYMMETRY","pval":0.46279,"padj":0.90517,"ES":-0.52362,"NES":-0.97386,"nMoreExtreme":10557,"size":90,"leadingEdge":["MICAL2","SOX17","DLL1","DNAAF4","IFT172","PCSK6","DISP1","RTTN","CC2D2A","GREM2","STIL","BMP4","ENG"]} {"pathway":"GO_INTRA_S_DNA_DAMAGE_CHECKPOINT","pval":0.60152,"padj":0.94684,"ES":-0.73987,"NES":-0.97429,"nMoreExtreme":24746,"size":14,"leadingEdge":["EME1","MSH2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_METALLOPEPTIDASE_ACTIVITY","pval":0.59188,"padj":0.94354,"ES":-0.68873,"NES":-0.97528,"nMoreExtreme":27422,"size":6,"leadingEdge":["ANTXR1"]} {"pathway":"GO_HISTONE_H3_K4_METHYLATION","pval":0.46062,"padj":0.90517,"ES":-0.59767,"NES":-0.97586,"nMoreExtreme":14001,"size":46,"leadingEdge":["BRCA1","MYB"]} {"pathway":"GO_REGULATION_OF_PROTEIN_HETERODIMERIZATION_ACTIVITY","pval":0.63066,"padj":0.94878,"ES":-0.7183,"NES":-0.97595,"nMoreExtreme":28317,"size":8,"leadingEdge":["BCL2"]} {"pathway":"GO_CHONDROITIN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS","pval":0.47345,"padj":0.90882,"ES":-0.64439,"NES":-0.97679,"nMoreExtreme":16048,"size":33,"leadingEdge":["XYLT1","VCAN","CHST13","CHST7"]} {"pathway":"GO_ADENOSINE_RECEPTOR_SIGNALING_PATHWAY","pval":0.61076,"padj":0.94703,"ES":-0.74303,"NES":-0.97699,"nMoreExtreme":25505,"size":13,"leadingEdge":["NECAB2","ADORA3"]} {"pathway":"GO_MOLTING_CYCLE_PROCESS","pval":0.45304,"padj":0.90517,"ES":-0.55218,"NES":-0.97795,"nMoreExtreme":11828,"size":68,"leadingEdge":["EDA","CELSR1","FZD3","BCL2","SNAI1","LGR4","FOXE1","CD109","MYO5A","WNT10B"]} {"pathway":"GO_ANIMAL_ORGAN_MATURATION","pval":0.54362,"padj":0.93045,"ES":-0.72193,"NES":-0.97808,"nMoreExtreme":20974,"size":19,"leadingEdge":["XYLT1","RFLNB","RYR1","BMP2","FGFR3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TELOMERASE_ACTIVITY","pval":0.46817,"padj":0.90738,"ES":-0.64183,"NES":-0.97942,"nMoreExtreme":15737,"size":34,"leadingEdge":["PKIB","AURKB","NEK2","PARM1"]} {"pathway":"GO_REGULATION_OF_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS","pval":0.5248,"padj":0.92669,"ES":-0.71175,"NES":-0.98011,"nMoreExtreme":19818,"size":21,"leadingEdge":["ADAM8"]} {"pathway":"GO_ARTERY_DEVELOPMENT","pval":0.44597,"padj":0.90517,"ES":-0.54768,"NES":-0.98026,"nMoreExtreme":11316,"size":72,"leadingEdge":["NRP1","HPGD","NOTCH3","HEY1","BMP4","GJA5","ENG","PLXND1"]} {"pathway":"GO_REGULATION_OF_EPITHELIAL_TUBE_FORMATION","pval":0.56176,"padj":0.93517,"ES":-0.73355,"NES":-0.98049,"nMoreExtreme":22229,"size":17,"leadingEdge":["CELSR1"]} {"pathway":"GO_OOCYTE_DIFFERENTIATION","pval":0.46392,"padj":0.90527,"ES":-0.62985,"NES":-0.98062,"nMoreExtreme":15184,"size":37,"leadingEdge":["DMC1","PDE3A","FBXO5","BCL2","TRIP13"]} {"pathway":"GO_POSITIVE_REGULATION_OF_DEVELOPMENTAL_GROWTH","pval":0.44726,"padj":0.90517,"ES":-0.49632,"NES":-0.98125,"nMoreExtreme":7814,"size":136,"leadingEdge":["SYT1","NRP1","AGR2","GHRL","CDK1","DLL1","INSR","CPNE5","PARP2","BCL2","AKAP6","TGFBR3"]} {"pathway":"GO_REGULATION_OF_GROWTH_RATE","pval":0.5531,"padj":0.93341,"ES":-0.67365,"NES":-0.98174,"nMoreExtreme":26044,"size":5,"leadingEdge":["GHRL"]} {"pathway":"GO_POSITIVE_REGULATION_OF_OSTEOBLAST_PROLIFERATION","pval":0.62852,"padj":0.94878,"ES":-0.72291,"NES":-0.9822,"nMoreExtreme":28221,"size":8,"leadingEdge":["TMEM119"]} {"pathway":"GO_PROTEOGLYCAN_METABOLIC_PROCESS","pval":0.44708,"padj":0.90517,"ES":-0.56647,"NES":-0.98235,"nMoreExtreme":12216,"size":61,"leadingEdge":["XYLT1","VCAN","CHST13","HS3ST1","CHST7"]} {"pathway":"GO_CELLULAR_PIGMENTATION","pval":0.45023,"padj":0.90517,"ES":-0.59578,"NES":-0.98243,"nMoreExtreme":13500,"size":48,"leadingEdge":["MYO7A","RAB17","BCL2","TYRP1","MYO5A","SHROOM3"]} {"pathway":"GO_LIPID_OXIDATION","pval":0.44608,"padj":0.90517,"ES":-0.5315,"NES":-0.98258,"nMoreExtreme":10328,"size":87,"leadingEdge":["PDK4","APPL2","HADH","ACOX2","IRS2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY","pval":0.55291,"padj":0.93341,"ES":-0.67448,"NES":-0.98294,"nMoreExtreme":26035,"size":5,"leadingEdge":["STMN1"]} {"pathway":"GO_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT","pval":0.44156,"padj":0.90167,"ES":-0.55336,"NES":-0.98304,"nMoreExtreme":11473,"size":69,"leadingEdge":["CDK1","CXADR","DLL1","TP73","PARP2","AKAP6","TGFBR3","RBP4","FZD7","FGFR1","KAT2A","JARID2","BMP4"]} {"pathway":"GO_EPIDERMIS_DEVELOPMENT","pval":0.44771,"padj":0.90517,"ES":-0.47361,"NES":-0.98473,"nMoreExtreme":5483,"size":209,"leadingEdge":["LAMB3","EDA","CELSR1","DLL1","SLC4A7","INSR","FZD3","MYO7A","BCL2","EMP1","SNAI1","LGR4","KRT80","FOXE1","IFT172","PCSK6","FGFR1","KRT10","SLC9A3R1","CD109","BMP4","KRT7","MYO5A"]} {"pathway":"GO_REGULATION_OF_ACROSOME_REACTION","pval":0.62757,"padj":0.94878,"ES":-0.72506,"NES":-0.98512,"nMoreExtreme":28178,"size":8,"leadingEdge":["PLB1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION","pval":0.43812,"padj":0.90126,"ES":-0.52277,"NES":-0.98519,"nMoreExtreme":9500,"size":98,"leadingEdge":["E2F8","E2F1","CDKN2C","CDK1","GTSE1","WEE1","CDC25C","KANK2","E2F7","JADE1","CTDSPL","BCL2","CDKN2B"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_PROCESS","pval":0.45333,"padj":0.90517,"ES":-0.457,"NES":-0.98564,"nMoreExtreme":3520,"size":306,"leadingEdge":["E2F8","E2F1","RRM2","CDKN2C","CDC6","CLSPN","TICRR","CDT1","CDK1","BRCA1","DTL","MAD2L1","ORC1","GTSE1","NDC80","AURKB","CCNF","BUB1B","CENPF","WEE1","CDC25C","KANK2","TTK","ESPL1","RAD51","E2F7","JADE1","CTDSPL","CHEK1","NEK2","FBXO5","BCL2","BUB1","CDC20","TRIP13","FZD9","FBXO43","BLM","PLK1","CDKN2B","KIF25"]} {"pathway":"GO_DEOXYRIBONUCLEOTIDE_BIOSYNTHETIC_PROCESS","pval":0.58079,"padj":0.94167,"ES":-0.74611,"NES":-0.98593,"nMoreExtreme":23567,"size":15,"leadingEdge":["RRM2","TYMS","SHMT1","RRM1","DUT"]} {"pathway":"GO_BLASTOCYST_GROWTH","pval":0.5457,"padj":0.93112,"ES":-0.73338,"NES":-0.98632,"nMoreExtreme":21369,"size":18,"leadingEdge":["NCAPG2","GINS1","GINS4"]} {"pathway":"GO_MORPHOGENESIS_OF_EMBRYONIC_EPITHELIUM","pval":0.43146,"padj":0.89981,"ES":-0.50347,"NES":-0.98806,"nMoreExtreme":7836,"size":129,"leadingEdge":["IFT122","CELSR1","FZD3","IRX3","GDF7","PRKACB","IFT172","CC2D2A","SEMA4C","KAT2A","SKI","STIL","BMP4","KIF20B","SHROOM3"]} {"pathway":"GO_REGULATION_OF_HISTONE_METHYLATION","pval":0.4337,"padj":0.90066,"ES":-0.58022,"NES":-0.98914,"nMoreExtreme":12342,"size":56,"leadingEdge":["BRCA1","MYB","LMNA","JARID2"]} {"pathway":"GO_CENTRAL_NERVOUS_SYSTEM_DEVELOPMENT","pval":0.47213,"padj":0.90882,"ES":-0.43318,"NES":-0.98964,"nMoreExtreme":575,"size":751,"leadingEdge":["S1PR1","INA","CX3CR1","SYT1","SELENOP","EPHB3","NRP1","E2F1","NRGN","SSBP3","CDKN2C","TAL1","TNFRSF21","PLXNA2","IFT122","CTTNBP2","OLIG1","RTN4RL1","SLC45A3","DAB1","TACC2","VCAN","CELSR1","STMN1","WWP1","DLL1","CENPF","WDR62","TYRO3","TP73","PDGFC","ADGRG1","KIF14","FZD3","ADCY1","CD9","ASPM","OLIG2","NOTCH3","SHC3","BCL2","DLX1","GLIS2","RRM1","DDIT4","DNER","GDF7","CDK5R1","TREM2","ADGRA2","TACC3","C5AR1","WLS","IFT172","SEZ6","FGFR1","SEMA4C","KAT2A","SLC6A11","NES","CCDC14","SKI","MYO1D","JARID2","NDRG2","IRS2","STIL","BMP4","ID3","NANOS1"]} {"pathway":"GO_REGULATION_OF_SYNAPSE_ASSEMBLY","pval":0.4243,"padj":0.89678,"ES":-0.5466,"NES":-0.98998,"nMoreExtreme":10458,"size":77,"leadingEdge":["EPHB3","GHRL","THBS2","SYNDIG1","RAB17","SRPX2","NECTIN1","FLRT3","LRRN1","CUX2","LRRTM1","LRRC4B"]} {"pathway":"GO_POSITIVE_REGULATION_OF_VASCULAR_PERMEABILITY","pval":0.61374,"padj":0.94703,"ES":-0.71629,"NES":-0.99044,"nMoreExtreme":28014,"size":7,"leadingEdge":["PDE3A","PDE2A"]} {"pathway":"GO_SPINDLE_ELONGATION","pval":0.62534,"padj":0.94878,"ES":-0.73068,"NES":-0.99276,"nMoreExtreme":28078,"size":8,"leadingEdge":["PRC1","AURKB","KIF4A","RACGAP1"]} {"pathway":"GO_CEREBRAL_CORTEX_TANGENTIAL_MIGRATION","pval":0.61282,"padj":0.94703,"ES":-0.71846,"NES":-0.99343,"nMoreExtreme":27972,"size":7,"leadingEdge":["NRP1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_GROWTH","pval":0.51916,"padj":0.92533,"ES":-0.72785,"NES":-0.99359,"nMoreExtreme":19824,"size":20,"leadingEdge":["CXADR","TP73","RBP4","JARID2","RGS4"]} {"pathway":"GO_EMBRYONIC_ORGAN_DEVELOPMENT","pval":0.41317,"padj":0.89503,"ES":-0.45877,"NES":-0.99503,"nMoreExtreme":2892,"size":328,"leadingEdge":["PCDH12","E2F8","KITLG","TAL1","EPAS1","IFT122","MICAL2","SOBP","CELSR1","SOX17","DLL1","PLCD3","PDGFC","FZD3","MYO7A","E2F7","PLK4","POLE","TBX15","SNAI1","HEY1","RBP4","RUNX2","FOXE1","IFT172","FGFR1","CC2D2A","NES","SLC9A3R1","STIL","BMP4","ID3","GJA5","ENG"]} {"pathway":"GO_ISOPRENOID_METABOLIC_PROCESS","pval":0.42368,"padj":0.89613,"ES":-0.56848,"NES":-0.99515,"nMoreExtreme":11341,"size":64,"leadingEdge":["PLB1","DHRS3","SDC2","LPL","RBP1","RBP4"]} {"pathway":"GO_OUTFLOW_TRACT_SEPTUM_MORPHOGENESIS","pval":0.49388,"padj":0.91907,"ES":-0.71152,"NES":-0.99587,"nMoreExtreme":18314,"size":23,"leadingEdge":["NRP1","BMP4","ENG"]} {"pathway":"GO_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING","pval":0.41229,"padj":0.89503,"ES":-0.5491,"NES":-0.99648,"nMoreExtreme":10086,"size":78,"leadingEdge":["PKIB","AURKB","RAD51","NEK2"]} {"pathway":"GO_MULTICELLULAR_ORGANISM_REPRODUCTION","pval":0.41823,"padj":0.89503,"ES":-0.44409,"NES":-0.99657,"nMoreExtreme":1224,"size":544,"leadingEdge":["TMEM119","TOP2A","MEIKIN","E2F1","TBATA","GHRL","PAQR5","DMC1","OCA2","SGPL1","CXADR","DAZL","NCAPH","SOX17","SYNE1","MERTK","PROK2","TYRO3","MYBL1","KIFC1","PMFBP1","PDE3A","CDC25C","TTK","GAMT","MCM8","HPGD","ASF1B","MAP2K6","DIAPH3","CD9","FANCG","ASPM","KNL1","ACE","FBXO5","BCL2","HMGB2","MNS1","TRIP13","PLK1","RPL39L","LGR4","DMRTA1","CIP2A","CFAP44","CCDC136","SPATA25","RETN","STOX2","PCNA","RACGAP1","NCAPH2","BMP4","SPIN4","PTX3","ROS1","MSH2","THRB","FOXO3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION","pval":0.40576,"padj":0.89503,"ES":-0.50872,"NES":-0.99738,"nMoreExtreme":7413,"size":128,"leadingEdge":["CX3CR1","SYT1","NRGN","STX1A","ADCY1","CACNA1D","NTSR1","CUX2","CCR2","RETN","LRRTM1"]} {"pathway":"GO_REGULATION_OF_DEVELOPMENTAL_GROWTH","pval":0.40485,"padj":0.89503,"ES":-0.46854,"NES":-0.99759,"nMoreExtreme":3773,"size":266,"leadingEdge":["SYT1","NRP1","AGR2","SEMA6B","GHRL","FSTL4","CDK1","SGPL1","CXADR","DLL1","GAMT","TP73","INSR","CPNE5","PARP2","BCL2","AKAP6","SEMA3G","TGFBR3","ADRB1","SEMA6C","CDK5R1","RBP4","FGFR1","SEMA4C"]} {"pathway":"GO_PATTERN_SPECIFICATION_PROCESS","pval":0.39719,"padj":0.89503,"ES":-0.4624,"NES":-0.9978,"nMoreExtreme":3080,"size":307,"leadingEdge":["NRP1","SSBP3","PLXNA2","IFT122","LRP5","XRCC2","MICAL2","CELSR1","SOX17","DLL1","ADGRG1","DLX1","MNS1","IRX3","SNAI1","DNAAF4","PRKACB","WLS","IFT172","PCSK6","DISP1","RTTN","FGFR1","CC2D2A","KAT2A","EFNB1","CELSR2","GREM2","SKI","STIL","BMP4"]} {"pathway":"GO_REGULATION_OF_SYNAPSE_STRUCTURE_OR_ACTIVITY","pval":0.40307,"padj":0.89503,"ES":-0.48841,"NES":-0.99805,"nMoreExtreme":5677,"size":179,"leadingEdge":["EPHB3","GHRL","CTTNBP2","THBS2","DNM1","SYNDIG1","RAB17","CDC20","SRPX2","ARHGAP22","FZD9","NECTIN1","TIAM1","CDK5R1","FLRT3","LRRN1","ITPKA","CUX2","CAMK1","LRRTM1","NGEF"]} {"pathway":"GO_EPITHELIAL_CELL_MATURATION","pval":0.61757,"padj":0.94878,"ES":-0.7595,"NES":-0.99976,"nMoreExtreme":26494,"size":11,"leadingEdge":["TYMS"]} {"pathway":"GO_DIGESTIVE_SYSTEM_DEVELOPMENT","pval":0.40515,"padj":0.89503,"ES":-0.52231,"NES":-0.99983,"nMoreExtreme":8194,"size":109,"leadingEdge":["EPHB3","AGR2","TYMS","HRH2","DAB1","SOX17","PDGFC","INSR","BCL2","LGR4","FOXE1","WLS","IFT172"]} {"pathway":"GO_GLIAL_CELL_APOPTOTIC_PROCESS","pval":0.58275,"padj":0.94167,"ES":-0.7594,"NES":-1,"nMoreExtreme":23974,"size":14,"leadingEdge":["TNFRSF21","DLL1","PRKCA"]} {"pathway":"GO_NUCLEOSIDE_MONOPHOSPHATE_METABOLIC_PROCESS","pval":0.4544,"padj":0.90517,"ES":-0.67949,"NES":-1.00003,"nMoreExtreme":15952,"size":29,"leadingEdge":["AK1","TYMS","AK7"]} {"pathway":"GO_INTESTINAL_EPITHELIAL_CELL_DIFFERENTIATION","pval":0.58273,"padj":0.94167,"ES":-0.7595,"NES":-1.00014,"nMoreExtreme":23973,"size":14,"leadingEdge":["TYMS"]} {"pathway":"GO_DNA_SYNTHESIS_INVOLVED_IN_DNA_REPAIR","pval":0.42014,"padj":0.89612,"ES":-0.60411,"NES":-1.00059,"nMoreExtreme":12533,"size":49,"leadingEdge":["PCLAF","DTL","POLE2","RFC3","RFC5","RFC4","POLA1","POLE","BLM"]} {"pathway":"GO_DENDRITE_EXTENSION","pval":0.4695,"padj":0.9079,"ES":-0.69775,"NES":-1.0016,"nMoreExtreme":16910,"size":26,"leadingEdge":["SYT1","CPNE5","PRKN","RASAL1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_EXPORT_FROM_NUCLEUS","pval":0.51106,"padj":0.92419,"ES":-0.734,"NES":-1.00198,"nMoreExtreme":19515,"size":20,"leadingEdge":["GTSE1","CAMK1"]} {"pathway":"GO_CYTOSKELETON_ORGANIZATION","pval":0.33555,"padj":0.87575,"ES":-0.43304,"NES":-1.0034,"nMoreExtreme":100,"size":1106,"leadingEdge":["MYOZ2","S1PR1","TRDN","INA","MTSS1","ABLIM3","NRP1","MYBL2","GHRL","SPC25","PCLAF","ANTXR1","KIF18B","CDK1","BIRC5","XRCC2","ANLN","BRCA1","PRC1","MICAL2","KIF11","CXADR","FGD5","TACC2","NUF2","NUSAP1","NDC80","AURKB","CELSR1","STMN1","CCNF","WDR62","SYNE1","FSCN1","PXN","ITGB5","WEE1","SKA3","KIFC1","TTK","ESPL1","RFLNB","SPAG5","MYOM1","NISCH","SKA1","CIT","AUNIP","ABLIM2","ARAP3","DIAPH3","GAS2L3","KIF2C","LIMCH1","ASPM","BAIAP2","CENPA","PLK4","FHOD1","SGO1","STRIP2","CHEK1","NEK2","TPX2","KIF4A","FBXO5","BCL2","CDC20","ANK1","KIF24","KIF20A","PLK1","CDK5R1","HIP1","ARHGAP6","KIF25","DNAAF4","LMNA","CFAP44","ALOX15","CATIP","XRCC3","SHROOM1","TACC3","ITPKA","IFT172","RTTN","CENPE","CC2D2A","KAT2A","FGD1","SIGLEC15","NES","SLC9A3R1","PARVB","CEP72","RCC1","RACGAP1","LMOD1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MITOTIC_CELL_CYCLE","pval":0.37347,"padj":0.89036,"ES":-0.46731,"NES":-1.0039,"nMoreExtreme":3166,"size":289,"leadingEdge":["E2F8","TOP2A","E2F1","CDKN2C","CDC6","CLSPN","TICRR","CDT1","ZWINT","CDK1","BRCA1","MAD2L1","ORC1","GTSE1","NDC80","AURKB","BUB1B","CENPF","EME1","WEE1","CDC25C","KANK2","TTK","FZD3","E2F7","JADE1","CTDSPL","CHEK1","FBXO5","BCL2","BUB1","CDC20","TRIP13","BLM","PLK1","CDKN2B","KIF25"]} {"pathway":"GO_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY","pval":0.41046,"padj":0.89503,"ES":-0.60437,"NES":-1.00557,"nMoreExtreme":12174,"size":50,"leadingEdge":["DAB2","BRCA1","CCNE1"]} {"pathway":"GO_ANATOMICAL_STRUCTURE_HOMEOSTASIS","pval":0.36647,"padj":0.89036,"ES":-0.46339,"NES":-1.00573,"nMoreExtreme":2565,"size":329,"leadingEdge":["S1PR1","PDK4","TNFRSF11A","CCNE2","ADAM8","EPAS1","PKIB","RECQL4","EXO1","FEN1","CXADR","POLE2","AURKB","TYRO3","PRKCA","RFC3","RFC5","RFC4","RAD51","TNFSF11","DNA2","POLA1","NEK2","BCL2","POLE","CACNA1D","BLM","RBP4","XRCC3","CCR2","CCNE1","SIGLEC15"]} {"pathway":"GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DEVELOPMENT","pval":0.42101,"padj":0.89612,"ES":-0.62552,"NES":-1.00608,"nMoreExtreme":13111,"size":43,"leadingEdge":["TYMS","DLL1","SLC4A7","MYO7A","FGFR1","SLC9A3R1","BMP6","BMP4","ROS1"]} {"pathway":"GO_NUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS","pval":0.40523,"padj":0.89503,"ES":-0.5749,"NES":-1.00639,"nMoreExtreme":10847,"size":64,"leadingEdge":["PID1","AK1","TYMS","TREM2","AK7"]} {"pathway":"GO_NEURON_PROJECTION_EXTENSION","pval":0.38153,"padj":0.89036,"ES":-0.50737,"NES":-1.00666,"nMoreExtreme":6535,"size":140,"leadingEdge":["SYT1","NRP1","SEMA6B","CPNE5","SEMA3G","SEMA6C","TIAM1","CDK5R1","FLRT3","SEMA4C","RAPH1","PRKN","RASAL1"]} {"pathway":"GO_CENTRIOLE_CENTRIOLE_COHESION","pval":0.57753,"padj":0.94163,"ES":-0.76511,"NES":-1.00753,"nMoreExtreme":23759,"size":14,"leadingEdge":["SGO1","NEK2","RTTN"]} {"pathway":"GO_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION","pval":0.35061,"padj":0.88569,"ES":-0.45677,"NES":-1.0081,"nMoreExtreme":1697,"size":414,"leadingEdge":["E2F8","E2F1","CDKN2C","CDC45","CDC25A","CDC6","CLSPN","TICRR","RECQL4","CDT1","CDCA5","CDK1","ANLN","BRCA1","DTL","MAD2L1","ORC1","GTSE1","NDC80","AURKB","BUB1B","CENPF","WEE1","CDC25C","KANK2","TTK","ESPL1","KIF14","E2F7","JADE1","UBE2C","CTDSPL","DLGAP5","PLK4","CHEK1","NEK2","TPX2","FBXO5","BCL2","BUB1","CDC20","TRIP13","BLM","PLK1","NEK10","CDKN2B","XRCC3","FAM83D","CENPE","CCNE1","HMMR","CEP72","PCNA","DONSON","ATAD5","CDC7","RBL1"]} {"pathway":"GO_APICAL_PROTEIN_LOCALIZATION","pval":0.62267,"padj":0.94878,"ES":-0.75348,"NES":-1.00929,"nMoreExtreme":27470,"size":9,"leadingEdge":["CELSR1","SHROOM3"]} {"pathway":"GO_EMBRYONIC_BRAIN_DEVELOPMENT","pval":0.61893,"padj":0.94878,"ES":-0.76143,"NES":-1.00951,"nMoreExtreme":26957,"size":10,"leadingEdge":["CC2D2A"]} {"pathway":"GO_TOXIN_TRANSPORT","pval":0.42371,"padj":0.89613,"ES":-0.65377,"NES":-1.01139,"nMoreExtreme":13987,"size":36,"leadingEdge":["NRP1","ANTXR1","LRP5","HRH2","DNM1","SLC7A8"]} {"pathway":"GO_HEMATOPOIETIC_STEM_CELL_PROLIFERATION","pval":0.49276,"padj":0.91907,"ES":-0.73574,"NES":-1.01315,"nMoreExtreme":18608,"size":21,"leadingEdge":["KITLG","ACE"]} {"pathway":"GO_NEURON_PROJECTION_GUIDANCE","pval":0.34676,"padj":0.88264,"ES":-0.48557,"NES":-1.01359,"nMoreExtreme":4081,"size":217,"leadingEdge":["EPHB3","NRP1","SEMA6B","PLXNA2","GFRA2","DAB1","PRKCA","FZD3","SHC3","SEMA3G","NECTIN1","SEMA6C","GDF7","CDK5R1","FLRT3","SEMA4C","UNC5B","EFNB1","IRS2","ETV1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_AXON_GUIDANCE","pval":0.60687,"padj":0.94703,"ES":-0.73377,"NES":-1.0146,"nMoreExtreme":27700,"size":7,"leadingEdge":["NRP1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION","pval":0.33377,"padj":0.87575,"ES":-0.47274,"NES":-1.01556,"nMoreExtreme":2812,"size":290,"leadingEdge":["ABLIM3","AGR2","E2F1","NECAB2","CDT1","CDK1","GTSE1","NDC80","TP73","BCL2","GLIS2","PLK1","SORL1","CDK5R1","TREM2","ARHGEF16","CAMK1","CENPQ","KIF20B","PRKN"]} {"pathway":"GO_REGULATION_OF_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION","pval":0.38146,"padj":0.89036,"ES":-0.56905,"NES":-1.01583,"nMoreExtreme":9756,"size":71,"leadingEdge":["STMN1","SKA3","SKA1","CDK5R1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_DNA_REPLICATION","pval":0.41781,"padj":0.89503,"ES":-0.65671,"NES":-1.01594,"nMoreExtreme":13792,"size":36,"leadingEdge":["CDC6","FBXO5","BLM","DONSON"]} {"pathway":"GO_MATURE_B_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE","pval":0.54403,"padj":0.93088,"ES":-0.76532,"NES":-1.0167,"nMoreExtreme":21814,"size":16,"leadingEdge":["GPR183","DLL1"]} {"pathway":"GO_EYE_PHOTORECEPTOR_CELL_DEVELOPMENT","pval":0.51904,"padj":0.92533,"ES":-0.75604,"NES":-1.0168,"nMoreExtreme":20325,"size":18,"leadingEdge":["MYO7A","THRB"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH","pval":0.60822,"padj":0.94703,"ES":-0.77257,"NES":-1.01696,"nMoreExtreme":26093,"size":11,"leadingEdge":["ADRB1"]} {"pathway":"GO_CALCIUM_DEPENDENT_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES","pval":0.42088,"padj":0.89612,"ES":-0.67111,"NES":-1.0173,"nMoreExtreme":14266,"size":33,"leadingEdge":["PCDH12","PCDHGC3","CDH5","CDH26"]} {"pathway":"GO_RESPONSE_TO_LEUCINE","pval":0.60806,"padj":0.94703,"ES":-0.77284,"NES":-1.01731,"nMoreExtreme":26086,"size":11,"leadingEdge":["SESN3","SESN1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS","pval":0.38816,"padj":0.89286,"ES":-0.58318,"NES":-1.01753,"nMoreExtreme":10465,"size":63,"leadingEdge":["PKIB","DSCC1","AURKB","CHTF18","RFC3","RFC5","RFC4","NEK2","PARM1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT","pval":0.4453,"padj":0.90517,"ES":-0.70315,"NES":-1.01835,"nMoreExtreme":15897,"size":27,"leadingEdge":["RUNX2","BMP6","BMP4","BMP2"]} {"pathway":"GO_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS","pval":0.38325,"padj":0.89036,"ES":-0.59164,"NES":-1.01933,"nMoreExtreme":10640,"size":59,"leadingEdge":["PKD1L3","ASIC1","OR7A17","C5AR1","FFAR4","WNT10B"]} {"pathway":"GO_AMINOGLYCAN_CATABOLIC_PROCESS","pval":0.39079,"padj":0.89503,"ES":-0.61079,"NES":-1.02006,"nMoreExtreme":11471,"size":51,"leadingEdge":["LYVE1","SDC2","VCAN"]} {"pathway":"GO_CYTOKINETIC_PROCESS","pval":0.40773,"padj":0.89503,"ES":-0.65254,"NES":-1.02126,"nMoreExtreme":13203,"size":38,"leadingEdge":["ANLN","AURKB","KIF20A","CEP55","RACGAP1","KIF20B"]} {"pathway":"GO_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION","pval":0.26914,"padj":0.83693,"ES":-0.45226,"NES":-1.02127,"nMoreExtreme":600,"size":606,"leadingEdge":["EPHB3","NRP1","SEMA6B","FSTL4","TAL1","PLXNA2","ANTXR1","SDC2","HRH2","GFRA2","DAB1","COL23A1","STMN1","SOX17","MERTK","TYRO3","PRKCA","KIF14","FZD3","MYO7A","MELTF","ADCY1","BAIAP2","SHC3","BCL2","SEMA3G","NECTIN1","SEMA6C","GDF7","TIAM1","CDK5R1","FLRT3","UST","ITPKA","CUX2","FZD7","RADIL","COL4A4","SEMA4C","UNC5B","SLC9A3R1","EFNB1","CELSR2","PARVB","NGEF","IRS2","ETV1"]} {"pathway":"GO_NEURAL_CREST_CELL_DIFFERENTIATION","pval":0.36967,"padj":0.89036,"ES":-0.56938,"NES":-1.0214,"nMoreExtreme":9317,"size":73,"leadingEdge":["NRP1","KITLG","SEMA6B","HTR2B","SEMA3G","SEMA6C","SEMA4C","EFNB1","BMP4"]} {"pathway":"GO_DEVELOPMENT_OF_PRIMARY_FEMALE_SEXUAL_CHARACTERISTICS","pval":0.36779,"padj":0.89036,"ES":-0.56409,"NES":-1.02167,"nMoreExtreme":9065,"size":77,"leadingEdge":["KITLG","DMC1","SGPL1","INSR","FANCG","BCL2","DMRTA1","CYP19A1","RETN","PTX3","FOXO3"]} {"pathway":"GO_RESPONSE_TO_LIGHT_STIMULUS","pval":0.32078,"padj":0.86901,"ES":-0.48493,"NES":-1.02172,"nMoreExtreme":3433,"size":237,"leadingEdge":["CDC25A","PCLAF","FEN1","HRH2","DTL","AURKB","MAPK13","CHEK1","BCL2","PBK","HRH1","TP53INP1","CAT","PCNA","USP2","FOS","MSH2"]} {"pathway":"GO_SECONDARY_HEART_FIELD_SPECIFICATION","pval":0.60446,"padj":0.94684,"ES":-0.73955,"NES":-1.0226,"nMoreExtreme":27590,"size":7,"leadingEdge":["BMP4"]} {"pathway":"GO_REGULATION_OF_BONE_DEVELOPMENT","pval":0.49231,"padj":0.91907,"ES":-0.74956,"NES":-1.02322,"nMoreExtreme":18799,"size":20,"leadingEdge":["TMEM119","GHRL","RFLNB","TNFSF11","SIGLEC15"]} {"pathway":"GO_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION","pval":0.3489,"padj":0.88316,"ES":-0.52559,"NES":-1.02383,"nMoreExtreme":6582,"size":122,"leadingEdge":["NRP1","F2RL3","FGD5","ITSN1","MCF2L","STMN1","ARHGEF39","KANK2","ADGRG1","PLEKHG5","TIAM1","DNMBP","ARHGEF16","FGD1","NGEF"]} {"pathway":"GO_SYNAPSE_ASSEMBLY","pval":0.34376,"padj":0.88094,"ES":-0.52213,"NES":-1.02468,"nMoreExtreme":6243,"size":129,"leadingEdge":["EPHB3","GHRL","THBS2","SYNDIG1","RAB17","SRPX2","DNER","NECTIN1","FLRT3","LRRN1","CUX2","LRRTM1","LRRC4B","PLXND1","DNM3","IL1RAP","NLGN2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY","pval":0.60368,"padj":0.94684,"ES":-0.77865,"NES":-1.02496,"nMoreExtreme":25898,"size":11,"leadingEdge":["NECAB2"]} {"pathway":"GO_ENDOCARDIAL_CUSHION_DEVELOPMENT","pval":0.40603,"padj":0.89503,"ES":-0.66777,"NES":-1.02603,"nMoreExtreme":13540,"size":35,"leadingEdge":["SNAI1","HEY1","RBM24","BMP4","ENG","BMP2"]} {"pathway":"GO_SYMPATHETIC_GANGLION_DEVELOPMENT","pval":0.61305,"padj":0.94703,"ES":-0.75569,"NES":-1.02673,"nMoreExtreme":27526,"size":8,"leadingEdge":["NRP1","FZD3"]} {"pathway":"GO_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS","pval":0.53645,"padj":0.92816,"ES":-0.77299,"NES":-1.02688,"nMoreExtreme":21510,"size":16,"leadingEdge":["GHRL","KANK2"]} {"pathway":"GO_HEART_DEVELOPMENT","pval":0.26676,"padj":0.83635,"ES":-0.46345,"NES":-1.02782,"nMoreExtreme":1121,"size":450,"leadingEdge":["S1PR1","NRP1","IFT122","DHRS3","CDK1","MICAL2","CXADR","SOX17","DLL1","HTR2B","TP73","MYOM1","INSR","GJC1","PARP2","AKAP6","SGCD","C1orf127","TGFBR3","SNAI1","HEY1","CALCRL","DNAAF4","FLRT3","LMNA","RBP4","IFT172","FZD7","FGFR1","RYR1","CC2D2A","KAT2A","PCNA","JARID2","RBM24","STIL","TNNC1","BMP4","MYOM3","NRAP","ID3","GREB1L","GJA5","ENG"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_CELL_JUNCTION","pval":0.5891,"padj":0.94172,"ES":-0.7818,"NES":-1.02807,"nMoreExtreme":24929,"size":12,"leadingEdge":["NECTIN1","MARVELD3","MPP7"]} {"pathway":"GO_AUDITORY_RECEPTOR_CELL_MORPHOGENESIS","pval":0.60961,"padj":0.94703,"ES":-0.77545,"NES":-1.0281,"nMoreExtreme":26551,"size":10,"leadingEdge":["MYO7A","SLC9A3R1"]} {"pathway":"GO_TONGUE_DEVELOPMENT","pval":0.57676,"padj":0.94161,"ES":-0.78197,"NES":-1.02819,"nMoreExtreme":24085,"size":13,"leadingEdge":["BNC2","WNT10B"]} {"pathway":"GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE","pval":0.3238,"padj":0.86974,"ES":-0.5099,"NES":-1.02848,"nMoreExtreme":4991,"size":160,"leadingEdge":["PID1","AGR2","E2F1","NECAB2","DAB2","TP73","BCL2","FZD9","CDK5R1","TREM2","ARHGEF16"]} {"pathway":"GO_SEMAPHORIN_PLEXIN_SIGNALING_PATHWAY","pval":0.39269,"padj":0.89503,"ES":-0.65522,"NES":-1.03138,"nMoreExtreme":12596,"size":39,"leadingEdge":["NRP1","SEMA6B","PLXNA2","SEMA3G","SEMA6C","SEMA4C"]} {"pathway":"GO_INTESTINAL_EPITHELIAL_CELL_DEVELOPMENT","pval":0.6112,"padj":0.94703,"ES":-0.7595,"NES":-1.03192,"nMoreExtreme":27443,"size":8,"leadingEdge":["TYMS"]} {"pathway":"GO_SYNAPTIC_VESICLE_DOCKING","pval":0.5865,"padj":0.94167,"ES":-0.78515,"NES":-1.03247,"nMoreExtreme":24819,"size":12,"leadingEdge":["STX1A"]} {"pathway":"GO_REGULATION_OF_CENTROSOME_DUPLICATION","pval":0.38674,"padj":0.89277,"ES":-0.64861,"NES":-1.03323,"nMoreExtreme":12242,"size":41,"leadingEdge":["BRCA1","CCNF","PLK4","XRCC3","KAT2A","STIL"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_LEUCINE","pval":0.61163,"padj":0.94703,"ES":-0.77285,"NES":-1.03523,"nMoreExtreme":26983,"size":9,"leadingEdge":["SESN3","SESN1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_VIRAL_GENOME_REPLICATION","pval":0.39645,"padj":0.89503,"ES":-0.67864,"NES":-1.03559,"nMoreExtreme":13326,"size":34,"leadingEdge":["TOP2A","CD28"]} {"pathway":"GO_MALE_GAMETE_GENERATION","pval":0.26074,"padj":0.83006,"ES":-0.47727,"NES":-1.03567,"nMoreExtreme":1801,"size":331,"leadingEdge":["TMEM119","MEIKIN","E2F1","TBATA","DMC1","OCA2","SGPL1","DAZL","SOX17","SYNE1","MERTK","PROK2","TYRO3","MYBL1","KIFC1","PMFBP1","CDC25C","GAMT","MCM8","ASF1B","DIAPH3","FANCG","ASPM","KNL1","ACE","HMGB2","MNS1","TRIP13","RPL39L","LGR4","CIP2A","CFAP44","CCDC136","SPATA25"]} {"pathway":"GO_LIMBIC_SYSTEM_DEVELOPMENT","pval":0.34077,"padj":0.87818,"ES":-0.56845,"NES":-1.03601,"nMoreExtreme":8217,"size":80,"leadingEdge":["NRP1","DAB1","KIF14","DLX1","CDK5R1","FGFR1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_BIOSYNTHETIC_PROCESS","pval":0.57118,"padj":0.93993,"ES":-0.78809,"NES":-1.03624,"nMoreExtreme":23852,"size":13,"leadingEdge":["TNFRSF8","CCR2","THBS1"]} {"pathway":"GO_MYOFIBRIL_ASSEMBLY","pval":0.36852,"padj":0.89036,"ES":-0.62592,"NES":-1.03671,"nMoreExtreme":10993,"size":49,"leadingEdge":["MYOZ2","MYOM1","LMOD1","MYOM3","NRAP"]} {"pathway":"GO_TELENCEPHALON_GLIAL_CELL_MIGRATION","pval":0.47938,"padj":0.91524,"ES":-0.75998,"NES":-1.03745,"nMoreExtreme":18305,"size":20,"leadingEdge":["DAB1","ADGRG1","CDK5R1"]} {"pathway":"GO_DNA_BIOSYNTHETIC_PROCESS","pval":0.29958,"padj":0.85717,"ES":-0.51109,"NES":-1.0387,"nMoreExtreme":4392,"size":171,"leadingEdge":["TYMS","PKIB","PCLAF","TK1","DSCC1","DTL","POLE2","AURKB","CENPF","CHTF18","POLQ","RFC3","RFC5","RFC4","POLA1","NEK2","POLE","BLM","PARM1"]} {"pathway":"GO_AUDITORY_RECEPTOR_CELL_STEREOCILIUM_ORGANIZATION","pval":0.60996,"padj":0.94703,"ES":-0.77545,"NES":-1.03873,"nMoreExtreme":26909,"size":9,"leadingEdge":["MYO7A","SLC9A3R1"]} {"pathway":"GO_CYTOSKELETON_DEPENDENT_INTRACELLULAR_TRANSPORT","pval":0.29924,"padj":0.85717,"ES":-0.51309,"NES":-1.03881,"nMoreExtreme":4473,"size":166,"leadingEdge":["IFT122","WDR34","KIF4A","FNBP1L","IFT172","APBA1","MGARP","DYNC2H1","MYO5A"]} {"pathway":"GO_FORMATION_OF_EXTRACHROMOSOMAL_CIRCULAR_DNA","pval":0.54163,"padj":0.9293,"ES":-0.78644,"NES":-1.03921,"nMoreExtreme":21978,"size":15,"leadingEdge":["EXO1","DNA2","BLM","XRCC3"]} {"pathway":"GO_GERM_CELL_DEVELOPMENT","pval":0.30136,"padj":0.85813,"ES":-0.51762,"NES":-1.03962,"nMoreExtreme":4756,"size":155,"leadingEdge":["PAQR5","DMC1","OCA2","DAZL","PDE3A","FANCG","ASPM","KNL1","FBXO5","BCL2","HMGB2","TRIP13","CFAP44","CCDC136","BMP4","PTX3","MSH2","FOXO3"]} {"pathway":"GO_SPINDLE_LOCALIZATION","pval":0.38196,"padj":0.89036,"ES":-0.66049,"NES":-1.03968,"nMoreExtreme":12252,"size":39,"leadingEdge":["NUSAP1","NDC80","ESPL1","ASPM","CENPA","KIF25"]} {"pathway":"GO_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY","pval":0.30086,"padj":0.85813,"ES":-0.51772,"NES":-1.03981,"nMoreExtreme":4748,"size":155,"leadingEdge":["DAB2","CDH5","APPL2","HTRA1","PXN","ITGB5","HPGD","HTRA3","TGFBR3","LDLRAD4","CDKN2B","THBS1","CD109","SKI","FOS","ENG"]} {"pathway":"GO_RENAL_WATER_HOMEOSTASIS","pval":0.44047,"padj":0.90126,"ES":-0.73708,"NES":-1.04006,"nMoreExtreme":16151,"size":24,"leadingEdge":["ADCY1","ADCY4","PRKACB"]} {"pathway":"GO_STEROL_BIOSYNTHETIC_PROCESS","pval":0.34762,"padj":0.88271,"ES":-0.58898,"NES":-1.04013,"nMoreExtreme":9121,"size":67,"leadingEdge":["FAXDC2","SQLE","DHCR24"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ORGAN_GROWTH","pval":0.42059,"padj":0.89612,"ES":-0.71846,"NES":-1.04051,"nMoreExtreme":15015,"size":27,"leadingEdge":["CXADR","TP73","RBP4","JARID2","RGS4"]} {"pathway":"GO_ENDODERM_FORMATION","pval":0.36664,"padj":0.89036,"ES":-0.63754,"NES":-1.04096,"nMoreExtreme":11144,"size":46,"leadingEdge":["LAMB3","MMP9","SOX17","ITGB5","MMP8"]} {"pathway":"GO_POSITIVE_REGULATION_OF_FILOPODIUM_ASSEMBLY","pval":0.43113,"padj":0.89981,"ES":-0.73225,"NES":-1.04259,"nMoreExtreme":15648,"size":25,"leadingEdge":["NRP1","FSCN1","FNBP1L","TENM2","DNM3"]} {"pathway":"GO_REGULATION_OF_COLLATERAL_SPROUTING","pval":0.49697,"padj":0.91907,"ES":-0.77532,"NES":-1.04272,"nMoreExtreme":19461,"size":18,"leadingEdge":["FSTL4"]} {"pathway":"GO_RESPONSE_TO_X_RAY","pval":0.40285,"padj":0.89503,"ES":-0.70306,"NES":-1.04289,"nMoreExtreme":14023,"size":30,"leadingEdge":["THBD","XRCC2","BLM"]} {"pathway":"GO_CARDIOLIPIN_METABOLIC_PROCESS","pval":0.59837,"padj":0.94558,"ES":-0.75584,"NES":-1.04512,"nMoreExtreme":27312,"size":7,"leadingEdge":["LCLAT1"]} {"pathway":"GO_RESPONSE_TO_ANTIMETABOLITE","pval":0.59244,"padj":0.94378,"ES":-0.79411,"NES":-1.04531,"nMoreExtreme":25416,"size":11,"leadingEdge":["DHFR","BLM","DDX11"]} {"pathway":"GO_INTERLEUKIN_13_SECRETION","pval":0.59817,"padj":0.94558,"ES":-0.75621,"NES":-1.04564,"nMoreExtreme":27303,"size":7,"leadingEdge":["TNFRSF21"]} {"pathway":"GO_EMBRYONIC_RETINA_MORPHOGENESIS_IN_CAMERA_TYPE_EYE","pval":0.59817,"padj":0.94558,"ES":-0.75626,"NES":-1.0457,"nMoreExtreme":27303,"size":7,"leadingEdge":["RBP4"]} {"pathway":"GO_DEVELOPMENTAL_GROWTH","pval":0.18041,"padj":0.77541,"ES":-0.46734,"NES":-1.0461,"nMoreExtreme":570,"size":522,"leadingEdge":["S1PR1","G6PC","SYT1","NRP1","AGR2","SEMA6B","GHRL","FSTL4","TYMS","CDK1","XRCC2","SGPL1","CXADR","NCAPG2","DLL1","GINS1","GAMT","TP73","INSR","CPNE5","BNC2","ASPM","PARP2","BCL2","AKAP6","SEMA3G","FZD9","TGFBR3","ADRB1","SEMA6C","TIAM1","CDK5R1","KIF26B","FLRT3","CYP19A1","RBP4","FZD7","FGFR1","SEMA4C","KAT2A","GINS4","EVC","JARID2","APBA1","STIL","BMP4","PTX3","RAPH1","PRKN","FOXO3"]} {"pathway":"GO_SUBSTRATE_DEPENDENT_CEREBRAL_CORTEX_TANGENTIAL_MIGRATION","pval":0.54272,"padj":0.92999,"ES":-0.71846,"NES":-1.04704,"nMoreExtreme":25555,"size":5,"leadingEdge":["NRP1"]} {"pathway":"GO_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING","pval":0.18023,"padj":0.77529,"ES":-0.46859,"NES":-1.04829,"nMoreExtreme":586,"size":515,"leadingEdge":["PCDH12","E2F8","SSBP3","XYLT1","EPAS1","PLXNA2","IFT122","PLPP4","XRCC2","BRCA1","CENPU","NCAPG2","CELSR1","SOX17","DLL1","PLCD3","GINS1","INKA1","FZD3","ASF1B","E2F7","C5","PLK4","CCNB2","NEK2","DLX1","TBX15","SNAI1","GDF7","CDK5R1","HEY1","RBP4","PRKACB","RUNX2","IFT172","FGFR1","CC2D2A","SEMA4C","KAT2A","ETV2","STOX2","GINS4","SKI","APBA1","STIL","BMP4"]} {"pathway":"GO_REGULATION_OF_ATP_BIOSYNTHETIC_PROCESS","pval":0.57686,"padj":0.94161,"ES":-0.7976,"NES":-1.04884,"nMoreExtreme":24411,"size":12,"leadingEdge":["PID1","TREM2"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_LIGHT_STIMULUS","pval":0.315,"padj":0.86511,"ES":-0.55747,"NES":-1.04923,"nMoreExtreme":6879,"size":97,"leadingEdge":["CDC25A","AURKB","MAPK13","CHEK1","PBK","TP53INP1","PCNA"]} {"pathway":"GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION","pval":0.36934,"padj":0.89036,"ES":-0.66657,"NES":-1.04925,"nMoreExtreme":11847,"size":39,"leadingEdge":["CDH5","ATOH8","ETV2","BMP6","BMP4","CD24","WNT10B"]} {"pathway":"GO_POSITIVE_REGULATION_BY_HOST_OF_VIRAL_PROCESS","pval":0.56297,"padj":0.93517,"ES":-0.79819,"NES":-1.04952,"nMoreExtreme":23509,"size":13,"leadingEdge":["PC"]} {"pathway":"GO_DOSAGE_COMPENSATION","pval":0.50566,"padj":0.92004,"ES":-0.78529,"NES":-1.04965,"nMoreExtreme":20009,"size":17,"leadingEdge":["BRCA1"]} {"pathway":"GO_SPHINGOLIPID_METABOLIC_PROCESS","pval":0.33442,"padj":0.87575,"ES":-0.60207,"NES":-1.05049,"nMoreExtreme":9016,"size":63,"leadingEdge":["SGPL1","SERINC5"]} {"pathway":"GO_GAMMA_AMINOBUTYRIC_ACID_SIGNALING_PATHWAY","pval":0.51824,"padj":0.92533,"ES":-0.79092,"NES":-1.0507,"nMoreExtreme":20780,"size":16,"leadingEdge":["GABRA3","GABBR2","GABRE"]} {"pathway":"GO_COLLATERAL_SPROUTING","pval":0.42162,"padj":0.89612,"ES":-0.7387,"NES":-1.05177,"nMoreExtreme":15303,"size":25,"leadingEdge":["FSTL4"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION","pval":0.50283,"padj":0.91978,"ES":-0.78744,"NES":-1.05253,"nMoreExtreme":19897,"size":17,"leadingEdge":["LBH"]} {"pathway":"GO_ACTIN_CROSSLINK_FORMATION","pval":0.60377,"padj":0.94684,"ES":-0.78622,"NES":-1.05315,"nMoreExtreme":26636,"size":9,"leadingEdge":["BAIAP2"]} {"pathway":"GO_ENDOTHELIAL_CELL_MORPHOGENESIS","pval":0.57412,"padj":0.94135,"ES":-0.80089,"NES":-1.05317,"nMoreExtreme":24295,"size":12,"leadingEdge":["COL23A1","COL4A4"]} {"pathway":"GO_C21_STEROID_HORMONE_BIOSYNTHETIC_PROCESS","pval":0.48903,"padj":0.91689,"ES":-0.78337,"NES":-1.05355,"nMoreExtreme":19150,"size":18,"leadingEdge":["BMP6","BMP2"]} {"pathway":"GO_CEREBRAL_CORTEX_DEVELOPMENT","pval":0.30301,"padj":0.8595,"ES":-0.5607,"NES":-1.0553,"nMoreExtreme":6617,"size":97,"leadingEdge":["NRP1","DAB1","TACC2","WDR62","ADGRG1","KIF14","ASPM","CDK5R1","TACC3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_BIOSYNTHETIC_PROCESS","pval":0.54129,"padj":0.9293,"ES":-0.72465,"NES":-1.05606,"nMoreExtreme":25488,"size":5,"leadingEdge":["GHRL"]} {"pathway":"GO_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT","pval":0.25655,"padj":0.82758,"ES":-0.52061,"NES":-1.05804,"nMoreExtreme":3761,"size":171,"leadingEdge":["S1PR1","CDK1","CXADR","DLL1","TP73","MYOM1","GJC1","PARP2","AKAP6","SGCD","TGFBR3","LMNA","RBP4","FZD7","FGFR1","KAT2A","JARID2","TNNC1","BMP4","MYOM3","NRAP","GJA5","ENG"]} {"pathway":"GO_FOREGUT_MORPHOGENESIS","pval":0.60107,"padj":0.94649,"ES":-0.79037,"NES":-1.0587,"nMoreExtreme":26517,"size":9,"leadingEdge":["SOX17"]} {"pathway":"GO_FLAVONE_METABOLIC_PROCESS","pval":0.41064,"padj":0.89503,"ES":-0.79489,"NES":-1.0591,"nMoreExtreme":20516,"size":1,"leadingEdge":["UGT1A1"]} {"pathway":"GO_FLAVONOID_GLUCURONIDATION","pval":0.41064,"padj":0.89503,"ES":-0.79489,"NES":-1.0591,"nMoreExtreme":20516,"size":1,"leadingEdge":["UGT1A1"]} {"pathway":"GO_XENOBIOTIC_GLUCURONIDATION","pval":0.41064,"padj":0.89503,"ES":-0.79489,"NES":-1.0591,"nMoreExtreme":20516,"size":1,"leadingEdge":["UGT1A1"]} {"pathway":"GO_REGULATION_OF_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY","pval":0.35288,"padj":0.888,"ES":-0.66491,"NES":-1.05919,"nMoreExtreme":11170,"size":41,"leadingEdge":["E2F1","TP73","BCL2","FZD9","MPV17L"]} {"pathway":"GO_HOMOLOGOUS_CHROMOSOME_SEGREGATION","pval":0.37548,"padj":0.89036,"ES":-0.70354,"NES":-1.05955,"nMoreExtreme":12855,"size":32,"leadingEdge":["CCNE2","MEIKIN","DMC1","ESPL1","TRIP13","PLK1","CCNE1"]} {"pathway":"GO_ESTABLISHMENT_OF_EPITHELIAL_CELL_APICAL_BASAL_POLARITY","pval":0.57017,"padj":0.93921,"ES":-0.80597,"NES":-1.05985,"nMoreExtreme":24128,"size":12,"leadingEdge":["SLC9A3R1"]} {"pathway":"GO_REGULATION_OF_MICROVILLUS_ORGANIZATION","pval":0.60059,"padj":0.94613,"ES":-0.79127,"NES":-1.05991,"nMoreExtreme":26496,"size":9,"leadingEdge":["ATP8B1","FSCN1"]} {"pathway":"GO_SARCOMERE_ORGANIZATION","pval":0.37164,"padj":0.89036,"ES":-0.69983,"NES":-1.06083,"nMoreExtreme":12597,"size":33,"leadingEdge":["MYOZ2","MYOM1"]} {"pathway":"GO_URETERIC_BUD_ELONGATION","pval":0.59985,"padj":0.94564,"ES":-0.79227,"NES":-1.06126,"nMoreExtreme":26463,"size":9,"leadingEdge":["KIF26B","BMP4"]} {"pathway":"GO_CARDIAC_EPITHELIAL_TO_MESENCHYMAL_TRANSITION","pval":0.40437,"padj":0.89503,"ES":-0.73939,"NES":-1.06137,"nMoreExtreme":14564,"size":26,"leadingEdge":["TGFBR3","SNAI1","HEY1","ENG","BMP2"]} {"pathway":"GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_GABAERGIC","pval":0.45793,"padj":0.90517,"ES":-0.77783,"NES":-1.06181,"nMoreExtreme":17486,"size":20,"leadingEdge":["NISCH"]} {"pathway":"GO_GLIAL_CELL_DERIVED_NEUROTROPHIC_FACTOR_RECEPTOR_SIGNALING_PATHWAY","pval":0.5933,"padj":0.94378,"ES":-0.7682,"NES":-1.06221,"nMoreExtreme":27081,"size":7,"leadingEdge":["GFRA2"]} {"pathway":"GO_SOFT_PALATE_DEVELOPMENT","pval":0.54023,"padj":0.92877,"ES":-0.72964,"NES":-1.06333,"nMoreExtreme":25438,"size":5,"leadingEdge":["FOXE1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION","pval":0.36905,"padj":0.89036,"ES":-0.70156,"NES":-1.06345,"nMoreExtreme":12509,"size":33,"leadingEdge":["STMN1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_EXIT_FROM_MITOSIS","pval":0.54013,"padj":0.92877,"ES":-0.73001,"NES":-1.06387,"nMoreExtreme":25433,"size":5,"leadingEdge":["CDCA5","UBE2C"]} {"pathway":"GO_REGULATION_OF_CELL_CYCLE","pval":0.06593,"padj":0.60375,"ES":-0.46038,"NES":-1.06452,"nMoreExtreme":23,"size":1063,"leadingEdge":["CCNE2","E2F2","E2F8","TOP2A","E2F1","CD28","MYBL2","RRM2","CDKN2C","CDC45","TAL1","CDC25A","CDC6","PCLAF","CLSPN","TICRR","RECQL4","CDT1","LRP5","FEN1","CDCA5","ZWINT","PKMYT1","CDK1","ANLN","BRCA1","DTL","PRC1","MKI67","CCNA2","WDR76","KIF11","MAD2L1","ORC1","NUSAP1","GTSE1","NDC80","AURKB","CCNF","BUB1B","CENPF","EME1","WEE1","PDE3A","CDC25C","KANK2","PRKCA","TTK","TP73","ESPL1","SPAG5","CIT","HPGD","INSR","RAD51","KIF14","DNA2","FZD3","MAP2K6","E2F7","CDK15","JADE1","FOXM1","ASPM","UBE2C","CTDSPL","DLGAP5","PLK4","CCNB2","CHEK1","NEK2","TPX2","FBXO5","BCL2","BUB1","CDC20","TRIP13","KIF20A","FZD9","FBXO43","BLM","PLK1","SLF1","NEK10","CDK5R1","GPR3","CDKN2B","DHCR24","KIF25","PRKACB","CABLES1","XRCC3","TP53INP1","FAM83D","TACC3","FGFR1","CENPE","CDKN3","KAT2A","CCNE1","THBS1","DDX11","SLC9A3R1","LIN9","HMMR","CEP72","PCNA","RCC1","RACGAP1","USP51","DONSON","USP2","DDIAS","STIL","BMP4","ATAD5","CDC7","RBL1","ID3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS","pval":0.5363,"padj":0.92816,"ES":-0.80918,"NES":-1.06556,"nMoreExtreme":22063,"size":14,"leadingEdge":["SORL1"]} {"pathway":"GO_FEMALE_SEX_DIFFERENTIATION","pval":0.29083,"padj":0.85125,"ES":-0.57378,"NES":-1.06715,"nMoreExtreme":6634,"size":90,"leadingEdge":["KITLG","DMC1","SGPL1","MERTK","TYRO3","INSR","FANCG","BCL2","DMRTA1","CYP19A1","RBP4","RETN","PTX3","FOXO3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ATP_BIOSYNTHETIC_PROCESS","pval":0.59679,"padj":0.94558,"ES":-0.79761,"NES":-1.0684,"nMoreExtreme":26328,"size":9,"leadingEdge":["PID1","TREM2"]} {"pathway":"GO_MIDGUT_DEVELOPMENT","pval":0.5803,"padj":0.94163,"ES":-0.81172,"NES":-1.06849,"nMoreExtreme":24895,"size":11,"leadingEdge":["DAB1"]} {"pathway":"GO_HISTONE_H3_K9_ACETYLATION","pval":0.5803,"padj":0.94163,"ES":-0.81172,"NES":-1.06849,"nMoreExtreme":24895,"size":11,"leadingEdge":["BRCA1","CHEK1"]} {"pathway":"GO_REGULATION_OF_MUSCLE_ORGAN_DEVELOPMENT","pval":0.26807,"padj":0.83635,"ES":-0.55433,"NES":-1.06885,"nMoreExtreme":5279,"size":114,"leadingEdge":["CDK1","CXADR","SOX17","DLL1","CENPF","TP73","PARP2","BCL2","AKAP6","TGFBR3","RBP4","FZD7","FGFR1","KAT2A","JARID2","RBM24","BMP4","WNT10B","BMP2","RGS4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_GLYCOGEN_METABOLIC_PROCESS","pval":0.53438,"padj":0.92816,"ES":-0.81186,"NES":-1.06909,"nMoreExtreme":21984,"size":14,"leadingEdge":["INSR","IRS2","PPP1R3G"]} {"pathway":"GO_BODY_MORPHOGENESIS","pval":0.32726,"padj":0.87108,"ES":-0.65239,"NES":-1.07052,"nMoreExtreme":9884,"size":47,"leadingEdge":["SSBP3","IFT122","SGPL1","GREM2","SKI"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT","pval":0.22349,"padj":0.80742,"ES":-0.52119,"NES":-1.07062,"nMoreExtreme":3026,"size":187,"leadingEdge":["SYT1","ABLIM3","DAB2","GTSE1","SPAG5","CACNA1D","SORL1","CDK5R1","CAMK1","KIF20B","PRKN","PCNT"]} {"pathway":"GO_POLARIZED_EPITHELIAL_CELL_DIFFERENTIATION","pval":0.50206,"padj":0.91978,"ES":-0.80596,"NES":-1.07068,"nMoreExtreme":20131,"size":16,"leadingEdge":["SLC9A3R1"]} {"pathway":"GO_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS","pval":0.31331,"padj":0.86489,"ES":-0.62571,"NES":-1.07069,"nMoreExtreme":8852,"size":57,"leadingEdge":["XYLT1","VCAN","GAL3ST4","CHST13","HS3ST1","CHST7","UST"]} {"pathway":"GO_RESPONSE_TO_INACTIVITY","pval":0.5959,"padj":0.94465,"ES":-0.79965,"NES":-1.07113,"nMoreExtreme":26289,"size":9,"leadingEdge":["CAT"]} {"pathway":"GO_ADHERENS_JUNCTION_ORGANIZATION","pval":0.2523,"padj":0.82744,"ES":-0.54682,"NES":-1.07208,"nMoreExtreme":4609,"size":128,"leadingEdge":["NRP1","CDH5","LIMCH1","BCL2","NECTIN1","CDH26","ARHGAP6","THBS1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_HISTONE_METHYLATION","pval":0.36134,"padj":0.89036,"ES":-0.71187,"NES":-1.07209,"nMoreExtreme":12371,"size":32,"leadingEdge":["BRCA1","MYB","LMNA","JARID2"]} {"pathway":"GO_REGULATION_OF_CENTROSOME_CYCLE","pval":0.31082,"padj":0.86489,"ES":-0.62955,"NES":-1.07325,"nMoreExtreme":8845,"size":56,"leadingEdge":["BRCA1","KIF11","CCNF","PLK4","CHEK1","NEK2","KIF25","XRCC3","KAT2A","STIL"]} {"pathway":"GO_WNT_SIGNALING_PATHWAY_CALCIUM_MODULATING_PATHWAY","pval":0.35474,"padj":0.88844,"ES":-0.70377,"NES":-1.07394,"nMoreExtreme":11924,"size":34,"leadingEdge":["GNG2","FZD3"]} {"pathway":"GO_ARTERY_MORPHOGENESIS","pval":0.31548,"padj":0.86578,"ES":-0.64084,"NES":-1.07408,"nMoreExtreme":9213,"size":52,"leadingEdge":["NRP1","HPGD","NOTCH3","HEY1","BMP4","GJA5","ENG"]} {"pathway":"GO_LAMELLIPODIUM_ORGANIZATION","pval":0.28856,"padj":0.84937,"ES":-0.59313,"NES":-1.07426,"nMoreExtreme":7112,"size":77,"leadingEdge":["S1PR1","ABLIM3","FSCN1","ABLIM2"]} {"pathway":"GO_CHROMATIN_ORGANIZATION","pval":0.08846,"padj":0.65704,"ES":-0.47534,"NES":-1.07453,"nMoreExtreme":186,"size":617,"leadingEdge":["CDC45","TAL1","HELLS","MCM2","CENPM","OIP5","CDK1","BRCA1","CENPU","MKI67","CCNA2","CHAF1B","UHRF1","AURKB","CENPK","HJURP","HASPIN","PRKCA","ATAD2","CENPI","ASF1B","JADE1","CHAF1A","KNL1","CENPA","SUV39H2","CHEK1","CENPP","HMGB2","SMYD3","CENPH","HMGB3","MYB","PHF10","SNAI1","HIRIP3","CENPS","CBX7","LMNA","KAT2A","CBX2","DDX11","CENPN","SKI","RCCD1","JARID2","USP51","CENPQ"]} {"pathway":"GO_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS","pval":0.48715,"padj":0.91689,"ES":-0.71432,"NES":-1.0747,"nMoreExtreme":23361,"size":4,"leadingEdge":["GHRL"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY","pval":0.37302,"padj":0.89036,"ES":-0.73083,"NES":-1.07559,"nMoreExtreme":13095,"size":29,"leadingEdge":["IFT172","DISP1","EVC","ULK3"]} {"pathway":"GO_CONTRACTILE_ACTIN_FILAMENT_BUNDLE_ASSEMBLY","pval":0.27945,"padj":0.84181,"ES":-0.58285,"NES":-1.0757,"nMoreExtreme":6513,"size":86,"leadingEdge":["S1PR1","NRP1","STMN1","PXN","ITGB5","LIMCH1","FHOD1","ARHGAP6"]} {"pathway":"GO_CEREBELLAR_PURKINJE_CELL_LAYER_DEVELOPMENT","pval":0.44565,"padj":0.90517,"ES":-0.78834,"NES":-1.07616,"nMoreExtreme":17017,"size":20,"leadingEdge":["DLL1","KIF14","SEZ6"]} {"pathway":"GO_INNER_EAR_RECEPTOR_CELL_STEREOCILIUM_ORGANIZATION","pval":0.42153,"padj":0.89612,"ES":-0.77541,"NES":-1.07676,"nMoreExtreme":15777,"size":22,"leadingEdge":["MYO7A","SLC9A3R1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS","pval":0.45604,"padj":0.90517,"ES":-0.79539,"NES":-1.0776,"nMoreExtreme":17595,"size":19,"leadingEdge":["SYT1","STX1A","CACNA1D"]} {"pathway":"GO_REGULATION_OF_LONG_TERM_SYNAPTIC_POTENTIATION","pval":0.3428,"padj":0.87929,"ES":-0.69699,"NES":-1.07825,"nMoreExtreme":11316,"size":36,"leadingEdge":["CX3CR1","NRGN","ADCY1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_RECEPTOR_INTERNALIZATION","pval":0.57459,"padj":0.94135,"ES":-0.81918,"NES":-1.07832,"nMoreExtreme":24650,"size":11,"leadingEdge":["NECAB2","LRRTM1"]} {"pathway":"GO_GASTRO_INTESTINAL_SYSTEM_SMOOTH_MUSCLE_CONTRACTION","pval":0.56969,"padj":0.93919,"ES":-0.76153,"NES":-1.07837,"nMoreExtreme":26394,"size":6,"leadingEdge":["GHRL","HTR2B"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SYNAPSE_ORGANIZATION","pval":0.46781,"padj":0.90738,"ES":-0.80186,"NES":-1.07843,"nMoreExtreme":18319,"size":18,"leadingEdge":["FZD9","NGEF","DNM3"]} {"pathway":"GO_POSTSYNAPTIC_NEUROTRANSMITTER_RECEPTOR_INTERNALIZATION","pval":0.52668,"padj":0.92669,"ES":-0.81933,"NES":-1.07893,"nMoreExtreme":21667,"size":14,"leadingEdge":["DNM1"]} {"pathway":"GO_EMBRYO_DEVELOPMENT","pval":0.0603,"padj":0.58568,"ES":-0.47222,"NES":-1.07977,"nMoreExtreme":59,"size":797,"leadingEdge":["PCDH12","E2F8","TOP2A","NRP1","KITLG","SSBP3","XYLT1","TAL1","EPAS1","PLXNA2","LAMB3","IFT122","PLPP4","LRP5","MMP9","CDK1","XRCC2","BRCA1","CENPU","MICAL2","SOBP","NCAPG2","CELSR1","SOX17","DLL1","PLCD3","ITGB5","GINS1","HTR2B","PDGFC","INSR","INKA1","FZD3","ASF1B","MYO7A","E2F7","C5","PLK4","CCNB2","NEK2","DLX1","ATOH8","POLE","IRX3","TBX15","SNAI1","GDF7","CDK5R1","HEY1","FLRT3","RBP4","PRKACB","RUNX2","FOXE1","WLS","IFT172","PCSK6","FZD7","DISP1","FGFR1","CC2D2A","MMP8","SEMA4C","KAT2A","ETV2","NES","STOX2","SLC9A3R1","EFNB1","GREM2","GINS4","SKI","RACGAP1","APBA1","STIL","BMP4","ID3","KIF20B","GJA5","ENG","MSH2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_GRANULOCYTE_DIFFERENTIATION","pval":0.58818,"padj":0.94167,"ES":-0.78146,"NES":-1.08054,"nMoreExtreme":26847,"size":7,"leadingEdge":["TESC"]} {"pathway":"GO_MACROMOLECULE_METHYLATION","pval":0.17005,"padj":0.77295,"ES":-0.50936,"NES":-1.08168,"nMoreExtreme":1665,"size":256,"leadingEdge":["ARMT1","BRCA1","SUV39H2","SMYD3","MYB","LMNA","JARID2","FOS","SETD6","KMT5C"]} {"pathway":"GO_MITOTIC_G2_DNA_DAMAGE_CHECKPOINT","pval":0.44065,"padj":0.90126,"ES":-0.79256,"NES":-1.08192,"nMoreExtreme":16826,"size":20,"leadingEdge":["CLSPN","CDK1","BLM","DONSON"]} {"pathway":"GO_CEREBRAL_CORTEX_RADIALLY_ORIENTED_CELL_MIGRATION","pval":0.39107,"padj":0.89503,"ES":-0.75997,"NES":-1.08206,"nMoreExtreme":14194,"size":25,"leadingEdge":["DAB1","ADGRG1","CDK5R1"]} {"pathway":"GO_GAMETE_GENERATION","pval":0.11634,"padj":0.70006,"ES":-0.48833,"NES":-1.08219,"nMoreExtreme":513,"size":439,"leadingEdge":["TMEM119","TOP2A","MEIKIN","E2F1","TBATA","PAQR5","DMC1","OCA2","SGPL1","CXADR","DAZL","NCAPH","SOX17","SYNE1","MERTK","PROK2","TYRO3","MYBL1","KIFC1","PMFBP1","PDE3A","CDC25C","TTK","GAMT","MCM8","HPGD","ASF1B","DIAPH3","FANCG","ASPM","KNL1","ACE","FBXO5","BCL2","HMGB2","MNS1","TRIP13","PLK1","RPL39L","LGR4","CIP2A","CFAP44","CCDC136","SPATA25"]} {"pathway":"GO_G1_DNA_DAMAGE_CHECKPOINT","pval":0.29086,"padj":0.85125,"ES":-0.62457,"NES":-1.08311,"nMoreExtreme":7947,"size":61,"leadingEdge":["E2F8","E2F1","CDK1","GTSE1","CDC25C","E2F7"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CYTOSKELETON_ORGANIZATION","pval":0.2379,"padj":0.82177,"ES":-0.55664,"NES":-1.08352,"nMoreExtreme":4521,"size":121,"leadingEdge":["S1PR1","BRCA1","STMN1","CCNF","NEK2","ARHGAP6","KIF25","KAT2A","LMOD1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_GLUCOSE_IMPORT","pval":0.59026,"padj":0.94238,"ES":-0.80969,"NES":-1.08459,"nMoreExtreme":26040,"size":9,"leadingEdge":["PID1","APPL2"]} {"pathway":"GO_NEUTROPHIL_EXTRAVASATION","pval":0.59164,"padj":0.94337,"ES":-0.79837,"NES":-1.08472,"nMoreExtreme":26565,"size":8,"leadingEdge":["ADAM8"]} {"pathway":"GO_TRABECULA_MORPHOGENESIS","pval":0.32362,"padj":0.86974,"ES":-0.685,"NES":-1.08481,"nMoreExtreme":10302,"size":40,"leadingEdge":["S1PR1","SLC40A1","TGFBR3","HEY1","RBP4"]} {"pathway":"GO_G0_TO_G1_TRANSITION","pval":0.31719,"padj":0.86626,"ES":-0.6715,"NES":-1.08507,"nMoreExtreme":9773,"size":44,"leadingEdge":["E2F1","RRM2","BRCA1","RAD51","CHEK1"]} {"pathway":"GO_MAMMARY_GLAND_EPITHELIAL_CELL_PROLIFERATION","pval":0.38022,"padj":0.89036,"ES":-0.75593,"NES":-1.08512,"nMoreExtreme":13694,"size":26,"leadingEdge":["IQGAP3","TNFSF11"]} {"pathway":"GO_PHOTORECEPTOR_CELL_DEVELOPMENT","pval":0.38016,"padj":0.89036,"ES":-0.75601,"NES":-1.08523,"nMoreExtreme":13692,"size":26,"leadingEdge":["MYO7A","THRB"]} {"pathway":"GO_REGULATION_OF_HISTONE_H3_K9_ACETYLATION","pval":0.58922,"padj":0.94172,"ES":-0.81172,"NES":-1.08731,"nMoreExtreme":25994,"size":9,"leadingEdge":["BRCA1","CHEK1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION","pval":0.33969,"padj":0.87818,"ES":-0.71263,"NES":-1.08746,"nMoreExtreme":11418,"size":34,"leadingEdge":["TP73","OLIG2","TREM2","BMP2","NKX6-2"]} {"pathway":"GO_MUCUS_SECRETION","pval":0.58878,"padj":0.94167,"ES":-0.81271,"NES":-1.08864,"nMoreExtreme":25975,"size":9,"leadingEdge":["AGR2"]} {"pathway":"GO_TROPHOBLAST_GIANT_CELL_DIFFERENTIATION","pval":0.58015,"padj":0.94163,"ES":-0.82115,"NES":-1.08868,"nMoreExtreme":25268,"size":10,"leadingEdge":["E2F8","E2F7","PLK4","SNAI1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_HISTONE_H3_K9_ACETYLATION","pval":0.56736,"padj":0.93659,"ES":-0.76937,"NES":-1.08947,"nMoreExtreme":26286,"size":6,"leadingEdge":["BRCA1"]} {"pathway":"GO_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT","pval":0.32052,"padj":0.86901,"ES":-0.69238,"NES":-1.08989,"nMoreExtreme":10281,"size":39,"leadingEdge":["SOX17","DLL1","BCL2","RBM24","WNT10B"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_STIMULUS","pval":0.47296,"padj":0.90882,"ES":-0.81552,"NES":-1.09006,"nMoreExtreme":18715,"size":17,"leadingEdge":["LPL","CD9"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE","pval":0.24348,"padj":0.82387,"ES":-0.57124,"NES":-1.09008,"nMoreExtreme":4977,"size":107,"leadingEdge":["AGR2","E2F1","NECAB2","TP73","BCL2","CDK5R1","TREM2","ARHGEF16"]} {"pathway":"GO_RENAL_SYSTEM_VASCULATURE_MORPHOGENESIS","pval":0.58502,"padj":0.94167,"ES":-0.78848,"NES":-1.09025,"nMoreExtreme":26703,"size":7,"leadingEdge":["NRP1","NOTCH3","BMP4"]} {"pathway":"GO_OSTEOBLAST_DEVELOPMENT","pval":0.53445,"padj":0.92816,"ES":-0.82989,"NES":-1.0912,"nMoreExtreme":22318,"size":13,"leadingEdge":["LRP5","CLEC5A","RUNX2"]} {"pathway":"GO_GLUCOSE_IMPORT","pval":0.30003,"padj":0.85735,"ES":-0.66186,"NES":-1.09138,"nMoreExtreme":8996,"size":48,"leadingEdge":["PID1","APPL2","INSR"]} {"pathway":"GO_POSTSYNAPSE_ORGANIZATION","pval":0.21455,"padj":0.7999,"ES":-0.54942,"NES":-1.09165,"nMoreExtreme":3656,"size":141,"leadingEdge":["INA","EPHB3","NRP1","GHRL","INSR","ARHGAP22","FZD9","TIAM1","CDK5R1","ITPKA","CUX2","LRRTM1","NGEF","LRRC4B"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_UV","pval":0.2635,"padj":0.83269,"ES":-0.60586,"NES":-1.09206,"nMoreExtreme":6563,"size":75,"leadingEdge":["CDC25A","AURKB","MAPK13","CHEK1","PBK","TP53INP1","PCNA"]} {"pathway":"GO_ACROSOME_REACTION","pval":0.47041,"padj":0.9079,"ES":-0.81782,"NES":-1.09314,"nMoreExtreme":18614,"size":17,"leadingEdge":["PLB1","SYT6","PLCD4"]} {"pathway":"GO_DIGESTIVE_TRACT_MORPHOGENESIS","pval":0.31997,"padj":0.86901,"ES":-0.6987,"NES":-1.09351,"nMoreExtreme":10361,"size":38,"leadingEdge":["EPHB3","AGR2","SOX17","BCL2"]} {"pathway":"GO_CARTILAGE_MORPHOGENESIS","pval":0.41668,"padj":0.89503,"ES":-0.79526,"NES":-1.09511,"nMoreExtreme":15735,"size":21,"leadingEdge":["SNAI1","COL21A1"]} {"pathway":"GO_NEUROTRANSMITTER_RECEPTOR_INTERNALIZATION","pval":0.46834,"padj":0.90738,"ES":-0.81933,"NES":-1.09516,"nMoreExtreme":18532,"size":17,"leadingEdge":["DNM1"]} {"pathway":"GO_ANOIKIS","pval":0.34612,"padj":0.88254,"ES":-0.73878,"NES":-1.09587,"nMoreExtreme":12048,"size":30,"leadingEdge":["PDK4","E2F1","BCL2"]} {"pathway":"GO_GLOMERULUS_MORPHOGENESIS","pval":0.58329,"padj":0.94167,"ES":-0.7928,"NES":-1.09622,"nMoreExtreme":26624,"size":7,"leadingEdge":["MTSS1","NOTCH3","BMP4"]} {"pathway":"GO_REPRODUCTIVE_SYSTEM_DEVELOPMENT","pval":0.11563,"padj":0.70006,"ES":-0.50492,"NES":-1.09795,"nMoreExtreme":752,"size":343,"leadingEdge":["PCDH12","TESC","E2F8","KITLG","GHRL","EPAS1","DMC1","SGPL1","CCNF","PLCD3","HTRA1","MERTK","TYRO3","ADGRG1","INSR","MAMLD1","E2F7","FANCG","ASPM","PLK4","BCL2","HMGB2","RRM1","SNAI1","GDF7","LGR4","HEY1","DMRTA1","CYP19A1","RBP4","NUDT1","RETN","ETV2","STOX2","BMP6"]} {"pathway":"GO_BONE_DEVELOPMENT","pval":0.18517,"padj":0.77988,"ES":-0.53843,"NES":-1.09834,"nMoreExtreme":2676,"size":175,"leadingEdge":["TMEM119","GHRL","XYLT1","TAL1","DHRS3","LRP5","RFLNB","PDGFC","TNFSF11","TRIM45","RUNX2","IFT172","RYR1","SIGLEC15","BMP6","SKI","COL13A1","BMP4","ENG"]} {"pathway":"GO_LONG_TERM_SYNAPTIC_POTENTIATION","pval":0.26189,"padj":0.83196,"ES":-0.62016,"NES":-1.09834,"nMoreExtreme":6837,"size":68,"leadingEdge":["CX3CR1","NRGN","ADCY1","LRRTM1"]} {"pathway":"GO_REGULATION_OF_SYNAPTIC_VESICLE_PRIMING","pval":0.56548,"padj":0.93517,"ES":-0.77568,"NES":-1.0984,"nMoreExtreme":26199,"size":6,"leadingEdge":["STX1A"]} {"pathway":"GO_NEURON_APOPTOTIC_PROCESS","pval":0.17253,"padj":0.77332,"ES":-0.53336,"NES":-1.09895,"nMoreExtreme":2290,"size":192,"leadingEdge":["CX3CR1","ADAM8","NRP1","USP53","MYBL2","TNFRSF21","XRCC2","ITSN1","TYRO3","CIT","KIF14","BCL2","DLX1","FZD9","MYB","CDK5R1","BACE1","C5AR1","UNC5B","NES","MSH2","PRKN","THRB","FOXO3","CNTFR"]} {"pathway":"GO_PIGMENTATION","pval":0.25336,"padj":0.82744,"ES":-0.60434,"NES":-1.09924,"nMoreExtreme":6153,"size":79,"leadingEdge":["KITLG","OCA2","EDA","MYO7A","RAB17","BCL2","TYRP1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_HORMONE_SECRETION","pval":0.29505,"padj":0.85578,"ES":-0.67354,"NES":-1.09975,"nMoreExtreme":8968,"size":46,"leadingEdge":["GHRL","CRHBP","OSM","HADH","ADRA2B","BMP8A","PRKN","NMB"]} {"pathway":"GO_CEREBRAL_CORTEX_CELL_MIGRATION","pval":0.31884,"padj":0.86883,"ES":-0.71145,"NES":-1.10061,"nMoreExtreme":10525,"size":36,"leadingEdge":["NRP1","DAB1","ADGRG1","CDK5R1"]} {"pathway":"GO_REGULATION_OF_TORC1_SIGNALING","pval":0.34155,"padj":0.87818,"ES":-0.742,"NES":-1.10064,"nMoreExtreme":11889,"size":30,"leadingEdge":["CASTOR1","SESN3","SESN1","RNF152"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS","pval":0.43645,"padj":0.90126,"ES":-0.81248,"NES":-1.10076,"nMoreExtreme":16839,"size":19,"leadingEdge":["NECAB2","LRRTM1"]} {"pathway":"GO_CARDIOLIPIN_ACYL_CHAIN_REMODELING","pval":0.53378,"padj":0.92816,"ES":-0.75584,"NES":-1.10151,"nMoreExtreme":25134,"size":5,"leadingEdge":["LCLAT1"]} {"pathway":"GO_PLACENTA_DEVELOPMENT","pval":0.20666,"padj":0.79637,"ES":-0.56447,"NES":-1.10307,"nMoreExtreme":3829,"size":125,"leadingEdge":["PCDH12","E2F8","GHRL","EPAS1","CCNF","PLCD3","HTRA1","E2F7","PLK4","SNAI1","HEY1","ETV2","STOX2"]} {"pathway":"GO_BONE_MATURATION","pval":0.4754,"padj":0.91084,"ES":-0.83084,"NES":-1.10374,"nMoreExtreme":19062,"size":16,"leadingEdge":["XYLT1","RFLNB","RYR1","BMP2","FGFR3"]} {"pathway":"GO_TUMOR_NECROSIS_FACTOR_BIOSYNTHETIC_PROCESS","pval":0.40839,"padj":0.89503,"ES":-0.80163,"NES":-1.10389,"nMoreExtreme":15422,"size":21,"leadingEdge":["CX3CR1","GHRL","TNFRSF8","CCR2","THBS1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELLULAR_RESPIRATION","pval":0.5641,"padj":0.93517,"ES":-0.77957,"NES":-1.10391,"nMoreExtreme":26135,"size":6,"leadingEdge":["CDK1"]} {"pathway":"GO_CARDIAC_MUSCLE_TISSUE_MORPHOGENESIS","pval":0.2814,"padj":0.84387,"ES":-0.66356,"NES":-1.10406,"nMoreExtreme":8346,"size":50,"leadingEdge":["S1PR1","MYOM1","TGFBR3","TNNC1","MYOM3","ENG","BMP2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_GROWTH","pval":0.23487,"padj":0.81909,"ES":-0.59128,"NES":-1.10513,"nMoreExtreme":5242,"size":93,"leadingEdge":["NRP1","SEMA6B","FSTL4","CXADR","TP73","SEMA3G","ADRB1","SEMA6C","CDK5R1","RBP4","SEMA4C","JARID2","BMP4"]} {"pathway":"GO_REGULATION_OF_POSTSYNAPTIC_DENSITY_ORGANIZATION","pval":0.54198,"padj":0.9293,"ES":-0.84048,"NES":-1.10523,"nMoreExtreme":22935,"size":12,"leadingEdge":["LRRTM1","LRRC4B","IL1RAP"]} {"pathway":"GO_SEXUAL_REPRODUCTION","pval":0.05457,"padj":0.56183,"ES":-0.49417,"NES":-1.10551,"nMoreExtreme":174,"size":518,"leadingEdge":["TMEM119","TOP2A","SELENOP","MEIKIN","E2F1","TBATA","PAQR5","PLB1","DMC1","SYT6","OCA2","CDK1","SGPL1","CXADR","DAZL","NCAPH","SOX17","SYNE1","MERTK","PROK2","TYRO3","MYBL1","KIFC1","PMFBP1","PDE3A","CDC25C","TTK","GAMT","MCM8","HPGD","ASF1B","DIAPH3","CD9","FANCG","ASPM","KNL1","ACE","FBXO5","BCL2","HMGB2","MNS1","TRIP13","PLK1","RPL39L","PLCD4","LGR4","DMRTA1","CIP2A","CFAP44","CCDC136","SPATA25"]} {"pathway":"GO_POSITIVE_REGULATION_OF_DNA_REPLICATION","pval":0.31282,"padj":0.86489,"ES":-0.71511,"NES":-1.10628,"nMoreExtreme":10326,"size":36,"leadingEdge":["E2F8","RECQL4","CDT1","CDK1","DNA2","E2F7","FGFR1","PCNA","ATAD5","CDC7","CDK2"]} {"pathway":"GO_TRABECULA_FORMATION","pval":0.41907,"padj":0.89569,"ES":-0.81045,"NES":-1.10635,"nMoreExtreme":16002,"size":20,"leadingEdge":["SLC40A1","TGFBR3","HEY1","RBP4","WNT10B"]} {"pathway":"GO_DEVELOPMENTAL_PROCESS_INVOLVED_IN_REPRODUCTION","pval":0.06201,"padj":0.59351,"ES":-0.49653,"NES":-1.10648,"nMoreExtreme":229,"size":483,"leadingEdge":["PCDH12","TMEM119","TESC","E2F8","KITLG","GHRL","PAQR5","EPAS1","DMC1","OCA2","SGPL1","DAZL","CCNF","PLCD3","HTRA1","MERTK","TYRO3","PDE3A","CENPI","ADGRG1","INSR","MAMLD1","E2F7","FANCG","ASPM","KNL1","PLK4","FBXO5","BCL2","HMGB2","RRM1","TRIP13","SNAI1","GDF7","LGR4","HEY1","DMRTA1","CYP19A1","CFAP44","CCDC136","RBP4","NUDT1","RETN","CBX2","ETV2","STOX2","BMP6"]} {"pathway":"GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_MATURATION","pval":0.53305,"padj":0.92816,"ES":-0.7595,"NES":-1.10685,"nMoreExtreme":25100,"size":5,"leadingEdge":["TYMS"]} {"pathway":"GO_REGULATION_OF_PRESYNAPTIC_CYTOSOLIC_CALCIUM_ION_CONCENTRATION","pval":0.55804,"padj":0.93517,"ES":-0.84207,"NES":-1.10845,"nMoreExtreme":23940,"size":11,"leadingEdge":["CACNA1D","CALB2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INSULIN_SECRETION","pval":0.33955,"padj":0.87818,"ES":-0.75357,"NES":-1.10906,"nMoreExtreme":11920,"size":29,"leadingEdge":["GHRL","HADH","BMP8A","PRKN"]} {"pathway":"GO_POSITIVE_REGULATION_OF_GASTRO_INTESTINAL_SYSTEM_SMOOTH_MUSCLE_CONTRACTION","pval":0.37858,"padj":0.89036,"ES":-0.72099,"NES":-1.10977,"nMoreExtreme":18835,"size":2,"leadingEdge":["GHRL"]} {"pathway":"GO_REGULATION_OF_CELLULAR_RESPIRATION","pval":0.36371,"padj":0.89036,"ES":-0.77955,"NES":-1.10994,"nMoreExtreme":13201,"size":25,"leadingEdge":["CDK1"]} {"pathway":"GO_NEUROEPITHELIAL_CELL_DIFFERENTIATION","pval":0.30493,"padj":0.86182,"ES":-0.71345,"NES":-1.11078,"nMoreExtreme":9980,"size":37,"leadingEdge":["DLL1","SLC4A7","MYO7A","FGFR1","SLC9A3R1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS","pval":0.20618,"padj":0.79637,"ES":-0.5762,"NES":-1.11102,"nMoreExtreme":4060,"size":114,"leadingEdge":["CX3CR1","ADAM8","NRP1","XRCC2","ITSN1","TYRO3","KIF14","BCL2","DLX1","FZD9","C5AR1","UNC5B","NES","MSH2","PRKN","CNTFR"]} {"pathway":"GO_ORGANELLE_ASSEMBLY","pval":0.03244,"padj":0.46062,"ES":-0.48809,"NES":-1.11115,"nMoreExtreme":45,"size":712,"leadingEdge":["MYOZ2","ABLIM3","MYBL2","IFT122","CDK1","BIRC5","ANLN","BRCA1","KIF11","AURKB","CENPK","CENPF","WDR62","MAP1LC3C","FSCN1","KIFC1","WDR34","SPAG5","ABCC4","MYOM1","MYO7A","UNC119B","ASPM","RAB17","KNL1","CENPA","PLK4","NEK2","TPX2","KIF4A","FBXO5","CDC20","MNS1","KIF24","ARMC9","CENPH","PLK1","KIF9","DNAAF4","CENPS","WDR90","CFAP44","CCDC136","TP53INP1","FNBP1L","IFT172","RTTN","CENPE","CC2D2A","KAT2A","LRRTM1","CENPN","CEP72","RCC1","RACGAP1","LMOD1","STIL","MYOM3","NRAP"]} {"pathway":"GO_REGULATION_OF_UBIQUITIN_PROTEIN_TRANSFERASE_ACTIVITY","pval":0.27946,"padj":0.84181,"ES":-0.67725,"NES":-1.11131,"nMoreExtreme":8440,"size":47,"leadingEdge":["MAD2L1","UBE2C","FBXO5","CDC20","PLK1"]} {"pathway":"GO_NEURAL_CREST_CELL_MIGRATION","pval":0.28373,"padj":0.846,"ES":-0.68408,"NES":-1.11145,"nMoreExtreme":8674,"size":45,"leadingEdge":["NRP1","KITLG","SEMA6B","HTR2B","SEMA3G","SEMA6C","SEMA4C","EFNB1","BMP4"]} {"pathway":"GO_PROTEIN_TRANSPORT_WITHIN_LIPID_BILAYER","pval":0.28594,"padj":0.84868,"ES":-0.6884,"NES":-1.11238,"nMoreExtreme":8810,"size":44,"leadingEdge":["DNM1","HIP1","LRRC7","CD24","DNM3"]} {"pathway":"GO_MUSCLE_ORGAN_MORPHOGENESIS","pval":0.25249,"padj":0.82744,"ES":-0.63985,"NES":-1.11299,"nMoreExtreme":6859,"size":62,"leadingEdge":["S1PR1","MYOM1","TGFBR3","TNNC1","MYOM3","ENG","BMP2"]} {"pathway":"GO_REPRODUCTION","pval":0.01837,"padj":0.35375,"ES":-0.48247,"NES":-1.11386,"nMoreExtreme":8,"size":989,"leadingEdge":["PCDH12","CCNE2","TMEM119","THBD","TESC","E2F8","TOP2A","SELENOP","MEIKIN","E2F1","TBATA","KITLG","GHRL","PAQR5","EPAS1","CDC25A","RAD54L","PLB1","EXO1","ANTXR1","DMC1","SYT6","MMP9","OCA2","PKMYT1","CDK1","XRCC2","SGPL1","CXADR","DAZL","CRHBP","NUF2","NCAPH","CCNF","SOX17","BUB1B","PLCD3","EME1","SYNE1","HTRA1","MERTK","PROK2","TYRO3","MYBL1","KIFC1","PMFBP1","PDE3A","MND1","CDC25C","TTK","GAMT","MCM8","ESPL1","CENPI","HPGD","ADGRG1","INSR","RAD51","MAMLD1","ASF1B","MAP2K6","E2F7","DIAPH3","CD9","FANCG","ASPM","KNL1","PLK4","PRLR","ACE","SGO1","NEK2","PSMC3IP","FBXO5","BCL2","BUB1","HMGB2","CDC20","NCAPD3","MNS1","RRM1","TRIP13","FBXO43","ADRA2B","BLM","PLK1","RPL39L","SMC4","SNAI1","GDF7","PLCD4","GPR3","LGR4","HEY1","SMC2","DMRTA1","CYP19A1","CENPS","CIP2A","CFAP44","CCDC136","RBP4","PRKACB","PLA2G4B","NUDT1","SPATA25","NCAPD2","CCNE1","RETN","CBX2","ETV2","STOX2","LIN9","BMP6","PCNA","RACGAP1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_DEVELOPMENTAL_PIGMENTATION","pval":0.57804,"padj":0.94163,"ES":-0.83164,"NES":-1.11398,"nMoreExtreme":25501,"size":9,"leadingEdge":["KITLG","BCL2"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_LEUCINE_STARVATION","pval":0.57777,"padj":0.94163,"ES":-0.83218,"NES":-1.11471,"nMoreExtreme":25489,"size":9,"leadingEdge":["SESN3","SESN1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ORGANELLE_ORGANIZATION","pval":0.09626,"padj":0.66591,"ES":-0.51401,"NES":-1.11483,"nMoreExtreme":673,"size":328,"leadingEdge":["S1PR1","TOP2A","CDT1","MCM2","BRCA1","MAD2L1","NDC80","AURKB","STMN1","CCNF","BUB1B","CENPF","TTK","ESPL1","ATAD2","CHEK1","NEK2","FBXO5","BUB1","CDC20","TRIP13","FZD9","FBXO43","PLK1","ARHGAP6","KIF25","MPV17L","LMNA","XRCC3","KAT2A","SKI","LMOD1","JARID2"]} {"pathway":"GO_CELLULAR_COMPONENT_ASSEMBLY_INVOLVED_IN_MORPHOGENESIS","pval":0.23146,"padj":0.81508,"ES":-0.6125,"NES":-1.11628,"nMoreExtreme":5581,"size":80,"leadingEdge":["MYOZ2","MYOM1","CD9","KNL1","CCDC136","PMP22","LMOD1","MYOM3","NRAP"]} {"pathway":"GO_AXONAL_FASCICULATION","pval":0.41019,"padj":0.89503,"ES":-0.81806,"NES":-1.11673,"nMoreExtreme":15663,"size":20,"leadingEdge":["EPHB3","NRP1","TNFRSF21","CDK5R1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SYNAPTIC_VESICLE_TRANSPORT","pval":0.58089,"padj":0.94167,"ES":-0.82206,"NES":-1.11691,"nMoreExtreme":26082,"size":8,"leadingEdge":["SYT1","CACNA1D"]} {"pathway":"GO_RESPONSE_TO_UV","pval":0.18318,"padj":0.77986,"ES":-0.5688,"NES":-1.11738,"nMoreExtreme":3307,"size":130,"leadingEdge":["CDC25A","PCLAF","FEN1","DTL","AURKB","MAPK13","CHEK1","BCL2","PBK","TP53INP1","CAT","PCNA"]} {"pathway":"GO_LABYRINTHINE_LAYER_DEVELOPMENT","pval":0.29683,"padj":0.85691,"ES":-0.71786,"NES":-1.11765,"nMoreExtreme":9715,"size":37,"leadingEdge":["PCDH12","PLCD3","HEY1"]} {"pathway":"GO_ACETYL_COA_BIOSYNTHETIC_PROCESS","pval":0.40825,"padj":0.89503,"ES":-0.81943,"NES":-1.1186,"nMoreExtreme":15589,"size":20,"leadingEdge":["PDK4"]} {"pathway":"GO_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION_INITIATION","pval":0.56074,"padj":0.93517,"ES":-0.79017,"NES":-1.11892,"nMoreExtreme":25979,"size":6,"leadingEdge":["TICRR","CDT1"]} {"pathway":"GO_REGULATION_OF_RECEPTOR_INTERNALIZATION","pval":0.28118,"padj":0.84355,"ES":-0.69973,"NES":-1.12016,"nMoreExtreme":8836,"size":42,"leadingEdge":["NECAB2","LRRTM1"]} {"pathway":"GO_REGULATION_OF_MICROVILLUS_ASSEMBLY","pval":0.56045,"padj":0.93517,"ES":-0.79127,"NES":-1.12048,"nMoreExtreme":25966,"size":6,"leadingEdge":["ATP8B1","FSCN1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NUCLEAR_DIVISION","pval":0.25632,"padj":0.82758,"ES":-0.66283,"NES":-1.12061,"nMoreExtreme":7386,"size":54,"leadingEdge":["CD28","CDT1","LRP5","CDCA5","NUSAP1","ESPL1","INSR","UBE2C","DLGAP5","SLF1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INTERLEUKIN_8_SECRETION","pval":0.51534,"padj":0.92459,"ES":-0.85237,"NES":-1.12076,"nMoreExtreme":21520,"size":13,"leadingEdge":["FCN1"]} {"pathway":"GO_ENERGY_COUPLED_PROTON_TRANSMEMBRANE_TRANSPORT_AGAINST_ELECTROCHEMICAL_GRADIENT","pval":0.37056,"padj":0.89036,"ES":-0.8011,"NES":-1.12124,"nMoreExtreme":13741,"size":23,"leadingEdge":["ATP6V0D2"]} {"pathway":"GO_AMACRINE_CELL_DIFFERENTIATION","pval":0.41822,"padj":0.89503,"ES":-0.72701,"NES":-1.122,"nMoreExtreme":20442,"size":3,"leadingEdge":["DLX1"]} {"pathway":"GO_DEVELOPMENTAL_GROWTH_INVOLVED_IN_MORPHOGENESIS","pval":0.13762,"padj":0.73301,"ES":-0.5427,"NES":-1.12232,"nMoreExtreme":1759,"size":199,"leadingEdge":["S1PR1","SYT1","NRP1","SEMA6B","FSTL4","CPNE5","SEMA3G","SEMA6C","TIAM1","CDK5R1","KIF26B","FLRT3","SEMA4C","BMP4","RAPH1","PRKN"]} {"pathway":"GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_OXIDATIVE_STRESS","pval":0.57464,"padj":0.94135,"ES":-0.83807,"NES":-1.12261,"nMoreExtreme":25351,"size":9,"leadingEdge":["EPAS1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY","pval":0.57448,"padj":0.94135,"ES":-0.83849,"NES":-1.12316,"nMoreExtreme":25344,"size":9,"leadingEdge":["IGFBP3"]} {"pathway":"GO_CREATINE_METABOLIC_PROCESS","pval":0.48044,"padj":0.91608,"ES":-0.74713,"NES":-1.12406,"nMoreExtreme":23039,"size":4,"leadingEdge":["GAMT","GATM"]} {"pathway":"GO_CELLULAR_ALDEHYDE_METABOLIC_PROCESS","pval":0.32429,"padj":0.86994,"ES":-0.76431,"NES":-1.12486,"nMoreExtreme":11384,"size":29,"leadingEdge":["BMP6","AKR7A2","ALDH7A1","BMP2"]} {"pathway":"GO_TORC1_SIGNALING","pval":0.28616,"padj":0.84868,"ES":-0.71892,"NES":-1.12515,"nMoreExtreme":9266,"size":38,"leadingEdge":["CASTOR1","SESN3","SESN1","RNF152"]} {"pathway":"GO_THYMOCYTE_MIGRATION","pval":0.53029,"padj":0.92803,"ES":-0.77231,"NES":-1.12551,"nMoreExtreme":24970,"size":5,"leadingEdge":["ADAM8","CCR2"]} {"pathway":"GO_FILOPODIUM_ASSEMBLY","pval":0.25228,"padj":0.82744,"ES":-0.66899,"NES":-1.12612,"nMoreExtreme":7314,"size":53,"leadingEdge":["NRP1","FGD5","FSCN1","RAB17","FNBP1L","FGD1","TENM2","DNM3"]} {"pathway":"GO_S_ADENOSYLMETHIONINE_METABOLIC_PROCESS","pval":0.54816,"padj":0.93125,"ES":-0.85613,"NES":-1.12695,"nMoreExtreme":23516,"size":11,"leadingEdge":["GAMT"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_AXONOGENESIS","pval":0.23517,"padj":0.81937,"ES":-0.64619,"NES":-1.12746,"nMoreExtreme":6340,"size":63,"leadingEdge":["NRP1","SEMA6B","FSTL4","DAB1","SEMA3G","SEMA6C","CDK5R1","SEMA4C"]} {"pathway":"GO_TELOMERE_CAPPING","pval":0.28338,"padj":0.84565,"ES":-0.72058,"NES":-1.12776,"nMoreExtreme":9176,"size":38,"leadingEdge":["PKIB","AURKB","NEK2"]} {"pathway":"GO_SINGLE_FERTILIZATION","pval":0.22293,"padj":0.80656,"ES":-0.63015,"NES":-1.12787,"nMoreExtreme":5656,"size":72,"leadingEdge":["PLB1","SYT6","CDK1","CD9","PLCD4","CCDC136"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_PH","pval":0.49124,"padj":0.91835,"ES":-0.85714,"NES":-1.12872,"nMoreExtreme":20209,"size":14,"leadingEdge":["PKD1L3","ASIC1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CYTOKINESIS","pval":0.33119,"padj":0.87332,"ES":-0.77981,"NES":-1.12937,"nMoreExtreme":11823,"size":27,"leadingEdge":["CDC6","AURKB","CIT","KIF14","RACGAP1","KIF20B"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_HISTONE_H3_K9_METHYLATION","pval":0.52719,"padj":0.92669,"ES":-0.85917,"NES":-1.12981,"nMoreExtreme":22309,"size":12,"leadingEdge":["BRCA1"]} {"pathway":"GO_REGULATION_OF_PIGMENT_CELL_DIFFERENTIATION","pval":0.57628,"padj":0.94161,"ES":-0.83164,"NES":-1.12993,"nMoreExtreme":25875,"size":8,"leadingEdge":["KITLG","BCL2"]} {"pathway":"GO_REGULATION_OF_DNA_METHYLATION","pval":0.45595,"padj":0.90517,"ES":-0.85122,"NES":-1.13081,"nMoreExtreme":18282,"size":16,"leadingEdge":["BRCA1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION","pval":0.57387,"padj":0.94135,"ES":-0.81798,"NES":-1.13104,"nMoreExtreme":26194,"size":7,"leadingEdge":["LMNA","BMP4","CTNNBIP1"]} {"pathway":"GO_LIPOXYGENASE_PATHWAY","pval":0.57135,"padj":0.94001,"ES":-0.84439,"NES":-1.13107,"nMoreExtreme":25206,"size":9,"leadingEdge":["LTC4S","HPGD","ALOX15","PON2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT","pval":0.26772,"padj":0.83635,"ES":-0.70331,"NES":-1.1312,"nMoreExtreme":8337,"size":43,"leadingEdge":["CXADR","DLL1","TP73","RBP4","FZD7","JARID2","BMP4","BMP2","RGS4"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_HISTONE_METHYLATION","pval":0.39678,"padj":0.89503,"ES":-0.82869,"NES":-1.13124,"nMoreExtreme":15151,"size":20,"leadingEdge":["BRCA1","JARID2"]} {"pathway":"GO_EPITHELIAL_CELL_MORPHOGENESIS","pval":0.33491,"padj":0.87575,"ES":-0.78844,"NES":-1.13178,"nMoreExtreme":12062,"size":26,"leadingEdge":["HRH2","COL23A1","COL4A4"]} {"pathway":"GO_AUDITORY_RECEPTOR_CELL_DEVELOPMENT","pval":0.48832,"padj":0.91689,"ES":-0.86024,"NES":-1.1328,"nMoreExtreme":20089,"size":14,"leadingEdge":["SLC4A7","MYO7A","FGFR1","SLC9A3R1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS","pval":0.39498,"padj":0.89503,"ES":-0.83008,"NES":-1.13314,"nMoreExtreme":15082,"size":20,"leadingEdge":["NRP1","SRPX2"]} {"pathway":"GO_MEMORY","pval":0.20752,"padj":0.79637,"ES":-0.61774,"NES":-1.13328,"nMoreExtreme":4923,"size":83,"leadingEdge":["CX3CR1","FEN1","HRH2","ASIC1","INSR","ADCY1","HRH1","CUX2","KAT2A"]} {"pathway":"GO_REGULATION_OF_DENDRITE_EXTENSION","pval":0.45363,"padj":0.90517,"ES":-0.85346,"NES":-1.13379,"nMoreExtreme":18189,"size":16,"leadingEdge":["SYT1","CPNE5","PRKN","RASAL1"]} {"pathway":"GO_ENDODERMAL_CELL_FATE_COMMITMENT","pval":0.50471,"padj":0.91988,"ES":-0.86439,"NES":-1.13657,"nMoreExtreme":21076,"size":13,"leadingEdge":["SOX17"]} {"pathway":"GO_RESPONSE_TO_FRUCTOSE","pval":0.55679,"padj":0.93517,"ES":-0.8027,"NES":-1.13667,"nMoreExtreme":25796,"size":6,"leadingEdge":["SLC2A5","KHK"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CAMP_MEDIATED_SIGNALING","pval":0.43483,"padj":0.9007,"ES":-0.8508,"NES":-1.13721,"nMoreExtreme":17206,"size":17,"leadingEdge":["PDE3B","PDE3A","PDE2A"]} {"pathway":"GO_REGULATION_OF_NUCLEOTIDE_BIOSYNTHETIC_PROCESS","pval":0.3177,"padj":0.86701,"ES":-0.77865,"NES":-1.13763,"nMoreExtreme":11247,"size":28,"leadingEdge":["PID1","PDK4","TREM2"]} {"pathway":"GO_CORPUS_CALLOSUM_DEVELOPMENT","pval":0.44999,"padj":0.90517,"ES":-0.85674,"NES":-1.13813,"nMoreExtreme":18043,"size":16,"leadingEdge":["EPHB3","RTN4RL1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT","pval":0.32175,"padj":0.86901,"ES":-0.78631,"NES":-1.13879,"nMoreExtreme":11486,"size":27,"leadingEdge":["CXADR","DLL1","TP73","RBP4","FZD7","JARID2","BMP2","RGS4"]} {"pathway":"GO_FOREBRAIN_REGIONALIZATION","pval":0.48339,"padj":0.91689,"ES":-0.86565,"NES":-1.13992,"nMoreExtreme":19886,"size":14,"leadingEdge":["ADGRG1","BMP4","BMP2"]} {"pathway":"GO_PHAGOCYTOSIS_RECOGNITION","pval":0.54067,"padj":0.92889,"ES":-0.86634,"NES":-1.14038,"nMoreExtreme":23195,"size":11,"leadingEdge":["COLEC12","FCN1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_FERTILIZATION","pval":0.57242,"padj":0.94008,"ES":-0.84006,"NES":-1.14137,"nMoreExtreme":25702,"size":8,"leadingEdge":["PLB1"]} {"pathway":"GO_RETINA_VASCULATURE_DEVELOPMENT_IN_CAMERA_TYPE_EYE","pval":0.43041,"padj":0.89981,"ES":-0.85498,"NES":-1.14281,"nMoreExtreme":17031,"size":17,"leadingEdge":["NRP1","LRP5"]} {"pathway":"GO_POSITIVE_REGULATION_OF_STEROID_HORMONE_SECRETION","pval":0.57072,"padj":0.93959,"ES":-0.82672,"NES":-1.14314,"nMoreExtreme":26050,"size":7,"leadingEdge":["GHRL","RETN","BMP6"]} {"pathway":"GO_REGULATION_OF_TELOMERE_CAPPING","pval":0.33217,"padj":0.87337,"ES":-0.8035,"NES":-1.14404,"nMoreExtreme":12056,"size":25,"leadingEdge":["PKIB","AURKB","NEK2"]} {"pathway":"GO_FAT_CELL_PROLIFERATION","pval":0.57107,"padj":0.93993,"ES":-0.84297,"NES":-1.14532,"nMoreExtreme":25641,"size":8,"leadingEdge":["PID1","E2F1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CILIUM_ASSEMBLY","pval":0.38437,"padj":0.89083,"ES":-0.83945,"NES":-1.14592,"nMoreExtreme":14677,"size":20,"leadingEdge":["MNS1"]} {"pathway":"GO_RETROGRADE_VESICLE_MEDIATED_TRANSPORT_GOLGI_TO_ENDOPLASMIC_RETICULUM","pval":0.19646,"padj":0.79068,"ES":-0.63003,"NES":-1.14597,"nMoreExtreme":4771,"size":79,"leadingEdge":["KIF15","KIF11","KIF26A","KIF2C","KIF4A","RAB6B","CENPE","RACGAP1","KIF22"]} {"pathway":"GO_REGULATION_OF_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY","pval":0.2788,"padj":0.84155,"ES":-0.75106,"NES":-1.14611,"nMoreExtreme":9371,"size":34,"leadingEdge":["LBH","BRCA1","KANK2","DNAAF4"]} {"pathway":"GO_SPHINGOLIPID_MEDIATED_SIGNALING_PATHWAY","pval":0.57058,"padj":0.93957,"ES":-0.84421,"NES":-1.14701,"nMoreExtreme":25619,"size":8,"leadingEdge":["S1PR1"]} {"pathway":"GO_HOMOPHILIC_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES","pval":0.16727,"padj":0.77278,"ES":-0.60017,"NES":-1.14705,"nMoreExtreme":3403,"size":108,"leadingEdge":["PCDH12","PCDHGC3","CDH5","CELSR1","PCDHGC4","PCDHGC5","PCDHAC2","NECTIN1","CDH26","PCDHAC1","IGSF21","CELSR2","PCDH1","PCDHGA11","CDH12","PCDH10"]} {"pathway":"GO_SYNAPSE_ORGANIZATION","pval":0.06113,"padj":0.58982,"ES":-0.52891,"NES":-1.14716,"nMoreExtreme":427,"size":328,"leadingEdge":["INA","CX3CR1","PCDHGC3","EPHB3","NRP1","GHRL","CTTNBP2","DLGAP3","THBS2","PCDHGC4","INSR","PCDHGC5","SYNDIG1","NFIA","RAB17","PPFIA2","CDC20","SRPX2","ARHGAP22","DNER","FZD9","NECTIN1","TIAM1","CDK5R1","FLRT3","SNCG","PDZRN3","LRRN1","C5AR1","ITPKA","CUX2","SEZ6","CAMK1","IGSF21","LRRTM1","NGEF"]} {"pathway":"GO_SEGMENT_SPECIFICATION","pval":0.55214,"padj":0.93307,"ES":-0.86531,"NES":-1.14723,"nMoreExtreme":24048,"size":10,"leadingEdge":["DLL1","IRX3"]} {"pathway":"GO_METHYLATION","pval":0.06851,"padj":0.61251,"ES":-0.53214,"NES":-1.14765,"nMoreExtreme":538,"size":304,"leadingEdge":["ARMT1","TYMS","BRCA1","GAMT","SUV39H2","SMYD3","MYB","LMNA","AMT","JARID2","FOS","AS3MT","SETD6","KMT5C"]} {"pathway":"GO_REGULATION_OF_FILOPODIUM_ASSEMBLY","pval":0.26278,"padj":0.83229,"ES":-0.73352,"NES":-1.148,"nMoreExtreme":8509,"size":38,"leadingEdge":["NRP1","FSCN1","RAB17","FNBP1L","TENM2","DNM3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT","pval":0.42522,"padj":0.89739,"ES":-0.85929,"NES":-1.14857,"nMoreExtreme":16826,"size":17,"leadingEdge":["SOX17","DLL1","BCL2","RBM24"]} {"pathway":"GO_ACTOMYOSIN_STRUCTURE_ORGANIZATION","pval":0.12854,"padj":0.72213,"ES":-0.57063,"NES":-1.14907,"nMoreExtreme":1997,"size":158,"leadingEdge":["MYOZ2","S1PR1","NRP1","ANLN","STMN1","PXN","ITGB5","MYOM1","LIMCH1","FHOD1","ARHGAP6","RACGAP1","LMOD1","MYOM3","NRAP"]} {"pathway":"GO_VAGINA_DEVELOPMENT","pval":0.55083,"padj":0.93215,"ES":-0.86794,"NES":-1.15073,"nMoreExtreme":23991,"size":10,"leadingEdge":["MERTK","TYRO3","RBP4"]} {"pathway":"GO_REGULATION_OF_CHROMOSOME_ORGANIZATION","pval":0.06647,"padj":0.60375,"ES":-0.53388,"NES":-1.15093,"nMoreExtreme":531,"size":301,"leadingEdge":["TOP2A","CDC45","TAL1","CDC6","PKIB","CDT1","MCM2","FEN1","CDCA5","BRCA1","MKI67","MAD2L1","NDC80","AURKB","BUB1B","CENPF","TTK","ESPL1","ATAD2","DLGAP5","CHEK1","NEK2","FBXO5","BUB1","CDC20","TRIP13","PLK1","SLF1","MYB","LMNA","XRCC3","TACC3","CENPE","KAT2A","DDX11","SKI","JARID2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_EMBRYONIC_DEVELOPMENT","pval":0.3263,"padj":0.87041,"ES":-0.80836,"NES":-1.15096,"nMoreExtreme":11843,"size":25,"leadingEdge":["SOX17","FZD3","SNAI1","PRKACB","FZD7","BMP4"]} {"pathway":"GO_APOPTOTIC_DNA_FRAGMENTATION","pval":0.39275,"padj":0.89503,"ES":-0.85034,"NES":-1.15204,"nMoreExtreme":15153,"size":19,"leadingEdge":["HMGB2"]} {"pathway":"GO_FEMALE_GAMETE_GENERATION","pval":0.17595,"padj":0.77529,"ES":-0.61574,"NES":-1.15256,"nMoreExtreme":3900,"size":94,"leadingEdge":["TOP2A","MEIKIN","PAQR5","DMC1","NCAPH","PDE3A","TTK","MCM8","HPGD","ASPM","FBXO5","BCL2","TRIP13","PLK1"]} {"pathway":"GO_MELANOCYTE_DIFFERENTIATION","pval":0.39177,"padj":0.89503,"ES":-0.85126,"NES":-1.15329,"nMoreExtreme":15115,"size":19,"leadingEdge":["KITLG","OCA2","BCL2","TYRP1"]} {"pathway":"GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_GAP_FILLING","pval":0.34225,"padj":0.87929,"ES":-0.82408,"NES":-1.15341,"nMoreExtreme":12691,"size":23,"leadingEdge":["RFC3","RFC5","RFC4","POLE","PCNA","POLD2","LIG1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS","pval":0.31467,"padj":0.86509,"ES":-0.80398,"NES":-1.15408,"nMoreExtreme":11333,"size":26,"leadingEdge":["DAB2","TGFBR3","CDKN2B","THBS1"]} {"pathway":"GO_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA","pval":0.09938,"padj":0.66778,"ES":-0.55724,"NES":-1.15459,"nMoreExtreme":1256,"size":202,"leadingEdge":["CX3CR1","DAB2","CDH5","APPL2","HTRA1","PXN","ITGB5","PDE3A","HPGD","PDE2A","HTRA3","DLX1","TGFBR3","LDLRAD4","CDKN2B","THBS1","CD109","SKI","CLEC3B","FOS","ENG"]} {"pathway":"GO_SMOOTHENED_SIGNALING_PATHWAY_INVOLVED_IN_DORSAL_VENTRAL_NEURAL_TUBE_PATTERNING","pval":0.4732,"padj":0.90882,"ES":-0.87691,"NES":-1.15475,"nMoreExtreme":19467,"size":14,"leadingEdge":["IFT122","PRKACB"]} {"pathway":"GO_HEART_MORPHOGENESIS","pval":0.10009,"padj":0.67038,"ES":-0.5584,"NES":-1.15479,"nMoreExtreme":1279,"size":199,"leadingEdge":["S1PR1","NRP1","DHRS3","MICAL2","SOX17","DLL1","HTR2B","MYOM1","INSR","TGFBR3","SNAI1","HEY1","RBP4","IFT172","RYR1","STIL","TNNC1","BMP4","MYOM3","GJA5","ENG"]} {"pathway":"GO_PHOSPHOLIPID_DEPHOSPHORYLATION","pval":0.27073,"padj":0.83739,"ES":-0.75729,"NES":-1.15561,"nMoreExtreme":9100,"size":34,"leadingEdge":["PLPP4","INPP5A"]} {"pathway":"GO_NEURONAL_STEM_CELL_POPULATION_MAINTENANCE","pval":0.37547,"padj":0.89036,"ES":-0.84715,"NES":-1.15643,"nMoreExtreme":14337,"size":20,"leadingEdge":["DLL1","ASPM","FOXO3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELL_CYCLE_ARREST","pval":0.1875,"padj":0.78227,"ES":-0.64351,"NES":-1.15691,"nMoreExtreme":4693,"size":74,"leadingEdge":["E2F8","E2F1","CDK1","BRCA1","GTSE1","CDC25C","TP73","E2F7","CDK5R1"]} {"pathway":"GO_REGULATION_OF_TRANSCRIPTION_INVOLVED_IN_CELL_FATE_COMMITMENT","pval":0.53186,"padj":0.92816,"ES":-0.87915,"NES":-1.15726,"nMoreExtreme":22817,"size":11,"leadingEdge":["SOX17","DLX1","ETV2","NKX6-2"]} {"pathway":"GO_REGULATION_OF_CHOLESTEROL_BIOSYNTHETIC_PROCESS","pval":0.24176,"padj":0.82373,"ES":-0.72432,"NES":-1.15953,"nMoreExtreme":7597,"size":42,"leadingEdge":["SQLE"]} {"pathway":"GO_CARDIAC_SEPTUM_MORPHOGENESIS","pval":0.19824,"padj":0.79183,"ES":-0.66266,"NES":-1.16002,"nMoreExtreme":5306,"size":64,"leadingEdge":["NRP1","DHRS3","TGFBR3","HEY1","BMP4","GJA5","ENG"]} {"pathway":"GO_POSTSYNAPTIC_MODULATION_OF_CHEMICAL_SYNAPTIC_TRANSMISSION","pval":0.48916,"padj":0.91689,"ES":-0.88297,"NES":-1.161,"nMoreExtreme":20427,"size":13,"leadingEdge":["NRGN","GHRL"]} {"pathway":"GO_INOSITOL_PHOSPHATE_MEDIATED_SIGNALING","pval":0.22543,"padj":0.81162,"ES":-0.70518,"NES":-1.16283,"nMoreExtreme":6759,"size":48,"leadingEdge":["MYOZ2","INPP5A","AKAP6","HOMER3","HRH1"]} {"pathway":"GO_DNA_STRAND_ELONGATION","pval":0.36981,"padj":0.89036,"ES":-0.85189,"NES":-1.16291,"nMoreExtreme":14121,"size":20,"leadingEdge":["GINS2","GINS1","RFC3","RFC4","DNA2","POLA1","POLE","GINS3","GINS4","PCNA","POLD2","LIG1"]} {"pathway":"GO_PURINE_NUCLEOSIDE_MONOPHOSPHATE_METABOLIC_PROCESS","pval":0.37956,"padj":0.89036,"ES":-0.86215,"NES":-1.16804,"nMoreExtreme":14644,"size":19,"leadingEdge":["AK1"]} {"pathway":"GO_PROTEIN_TRANSPORT_WITHIN_PLASMA_MEMBRANE","pval":0.25108,"padj":0.82605,"ES":-0.7555,"NES":-1.16875,"nMoreExtreme":8288,"size":36,"leadingEdge":["DNM1","HIP1","LRRC7"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELL_DIVISION","pval":0.18505,"padj":0.77988,"ES":-0.6662,"NES":-1.17054,"nMoreExtreme":4925,"size":65,"leadingEdge":["LBH","TAL1","CDC6","OSM","AURKB","HTR2B","PDGFC","CIT","KIF14","PPBP","CAT","RACGAP1"]} {"pathway":"GO_THALAMUS_DEVELOPMENT","pval":0.55499,"padj":0.93402,"ES":-0.87436,"NES":-1.17121,"nMoreExtreme":24484,"size":9,"leadingEdge":["OLIG2"]} {"pathway":"GO_INTERLEUKIN_5_SECRETION","pval":0.54994,"padj":0.93134,"ES":-0.8272,"NES":-1.17136,"nMoreExtreme":25479,"size":6,"leadingEdge":["TNFRSF21"]} {"pathway":"GO_REGULATION_OF_CELL_CYCLE_PROCESS","pval":0.00692,"padj":0.21717,"ES":-0.51698,"NES":-1.17504,"nMoreExtreme":10,"size":683,"leadingEdge":["CCNE2","E2F8","E2F1","CD28","RRM2","CDKN2C","CDC45","CDC25A","CDC6","CLSPN","TICRR","RECQL4","CDT1","LRP5","FEN1","CDCA5","PKMYT1","CDK1","ANLN","BRCA1","DTL","PRC1","MKI67","CCNA2","KIF11","MAD2L1","ORC1","NUSAP1","GTSE1","NDC80","AURKB","CCNF","BUB1B","CENPF","WEE1","PDE3A","CDC25C","KANK2","TTK","TP73","ESPL1","SPAG5","CIT","INSR","RAD51","KIF14","E2F7","JADE1","FOXM1","UBE2C","CTDSPL","DLGAP5","PLK4","CCNB2","CHEK1","NEK2","TPX2","FBXO5","BCL2","BUB1","CDC20","TRIP13","KIF20A","FZD9","FBXO43","BLM","PLK1","SLF1","NEK10","CDK5R1","GPR3","CDKN2B","KIF25","XRCC3","FAM83D","TACC3","FGFR1","CENPE","KAT2A","CCNE1","DDX11","HMMR","CEP72","PCNA","RCC1","RACGAP1","USP51","DONSON","STIL","BMP4","ATAD5","CDC7","RBL1"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_GLUCAGON_STIMULUS","pval":0.40392,"padj":0.89503,"ES":-0.87976,"NES":-1.17593,"nMoreExtreme":15983,"size":17,"leadingEdge":["ADCY1","ADCY4","PRKACB"]} {"pathway":"GO_POSITIVE_REGULATION_OF_LONG_TERM_SYNAPTIC_POTENTIATION","pval":0.40329,"padj":0.89503,"ES":-0.88034,"NES":-1.1767,"nMoreExtreme":15958,"size":17,"leadingEdge":["NRGN","ADCY1"]} {"pathway":"GO_REGULATION_OF_MELANOCYTE_DIFFERENTIATION","pval":0.54861,"padj":0.93125,"ES":-0.83164,"NES":-1.17765,"nMoreExtreme":25417,"size":6,"leadingEdge":["KITLG","BCL2"]} {"pathway":"GO_VITAMIN_A_METABOLIC_PROCESS","pval":0.47416,"padj":0.90955,"ES":-0.78309,"NES":-1.17817,"nMoreExtreme":22738,"size":4,"leadingEdge":["RBP1"]} {"pathway":"GO_REGULATION_OF_MITOTIC_CELL_CYCLE","pval":0.01026,"padj":0.25928,"ES":-0.52262,"NES":-1.1796,"nMoreExtreme":24,"size":590,"leadingEdge":["CCNE2","E2F8","TOP2A","E2F1","CD28","CDKN2C","CDC45","TAL1","CDC25A","CDC6","CLSPN","TICRR","RECQL4","CDT1","LRP5","CDCA5","ZWINT","PKMYT1","CDK1","ANLN","BRCA1","DTL","MKI67","CCNA2","KIF11","MAD2L1","ORC1","NUSAP1","GTSE1","NDC80","AURKB","CCNF","BUB1B","CENPF","EME1","WEE1","CDC25C","KANK2","PRKCA","TTK","TP73","ESPL1","INSR","KIF14","FZD3","E2F7","JADE1","UBE2C","CTDSPL","DLGAP5","PLK4","CCNB2","CHEK1","NEK2","TPX2","FBXO5","BCL2","BUB1","CDC20","TRIP13","BLM","PLK1","SLF1","CDKN2B","KIF25","XRCC3","TACC3","FGFR1","CENPE","CCNE1","SLC9A3R1","HMMR","CEP72","PCNA","RCC1","DONSON","USP2","BMP4","ATAD5","CDC7","RBL1","KIF20B","MSH2","LSM11","TFAP4","CDK2"]} {"pathway":"GO_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE","pval":0.25778,"padj":0.82758,"ES":-0.78352,"NES":-1.18001,"nMoreExtreme":8825,"size":32,"leadingEdge":["CDT1","NUF2","NDC80","AURKB","SPAG5","KIF2C","KNL1","SGO1","NEK2","CENPE","RACGAP1"]} {"pathway":"GO_REGULATION_OF_CELL_CYCLE_ARREST","pval":0.14359,"padj":0.74282,"ES":-0.62834,"NES":-1.18095,"nMoreExtreme":3154,"size":96,"leadingEdge":["E2F8","E2F1","CDK1","BRCA1","GTSE1","CDC25C","TP73","E2F7","FOXM1","FZD9","CDK5R1"]} {"pathway":"GO_GLYCOPROTEIN_METABOLIC_PROCESS","pval":0.12815,"padj":0.72213,"ES":-0.61281,"NES":-1.18162,"nMoreExtreme":2523,"size":114,"leadingEdge":["XYLT1","HBEGF","VCAN","GAL3ST4","CHST13","HS3ST1","MAN1C1","CHST7","MGAT4A","PCSK6","PTX3","ST6GALNAC3","BMP2","DSEL","ST8SIA2"]} {"pathway":"GO_EYE_MORPHOGENESIS","pval":0.13236,"padj":0.72944,"ES":-0.61943,"NES":-1.18202,"nMoreExtreme":2705,"size":107,"leadingEdge":["IFT122","LRP5","DLL1","MYO7A","BCL2","NECTIN1","RBP4","SKI","BMP4","THRB"]} {"pathway":"GO_DORSAL_VENTRAL_NEURAL_TUBE_PATTERNING","pval":0.35284,"padj":0.888,"ES":-0.86715,"NES":-1.18375,"nMoreExtreme":13473,"size":20,"leadingEdge":["IFT122","PRKACB","BMP4"]} {"pathway":"GO_REGULATION_OF_HISTONE_H3_K9_METHYLATION","pval":0.35279,"padj":0.888,"ES":-0.86721,"NES":-1.18383,"nMoreExtreme":13471,"size":20,"leadingEdge":["BRCA1","MYB","LMNA","JARID2"]} {"pathway":"GO_CELLULAR_PROCESS_INVOLVED_IN_REPRODUCTION_IN_MULTICELLULAR_ORGANISM","pval":0.06745,"padj":0.60666,"ES":-0.56739,"NES":-1.18438,"nMoreExtreme":793,"size":217,"leadingEdge":["TMEM119","TOP2A","MEIKIN","PAQR5","DMC1","OCA2","CXADR","DAZL","NCAPH","MYBL1","PDE3A","TTK","CD9","FANCG","ASPM","KNL1","FBXO5","BCL2","HMGB2","TRIP13","PLK1","CFAP44","CCDC136","RETN","NCAPH2","BMP4","PTX3","MSH2","FOXO3"]} {"pathway":"GO_TORC2_SIGNALING","pval":0.55906,"padj":0.93517,"ES":-0.85752,"NES":-1.18572,"nMoreExtreme":25518,"size":7,"leadingEdge":["SESN3"]} {"pathway":"GO_SYNAPSE_MATURATION","pval":0.33597,"padj":0.87575,"ES":-0.86138,"NES":-1.18616,"nMoreExtreme":12687,"size":21,"leadingEdge":["CX3CR1","NFIA","CDC20","SEZ6","IGSF21"]} {"pathway":"GO_CYTOPLASMIC_MICROTUBULE_ORGANIZATION","pval":0.19761,"padj":0.79183,"ES":-0.71038,"NES":-1.1864,"nMoreExtreme":5800,"size":51,"leadingEdge":["TRDN","IFT172"]} {"pathway":"GO_PIGMENT_CELL_DIFFERENTIATION","pval":0.26749,"padj":0.83635,"ES":-0.80624,"NES":-1.18657,"nMoreExtreme":9390,"size":29,"leadingEdge":["KITLG","OCA2","BCL2","TYRP1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MITOTIC_NUCLEAR_DIVISION","pval":0.20778,"padj":0.79637,"ES":-0.72691,"NES":-1.18689,"nMoreExtreme":6315,"size":46,"leadingEdge":["CD28","CDT1","LRP5","CDCA5","NUSAP1","ESPL1","INSR","UBE2C","DLGAP5","SLF1"]} {"pathway":"GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_DIFFERENTIATION","pval":0.47288,"padj":0.90882,"ES":-0.90267,"NES":-1.18689,"nMoreExtreme":19747,"size":13,"leadingEdge":["CDK1","LMNA"]} {"pathway":"GO_MICROTUBULE_DEPOLYMERIZATION","pval":0.22488,"padj":0.81044,"ES":-0.75474,"NES":-1.18805,"nMoreExtreme":7213,"size":39,"leadingEdge":["KIF18B","STMN1","KIF2C","KIF24"]} {"pathway":"GO_TUBE_CLOSURE","pval":0.14856,"padj":0.7508,"ES":-0.64515,"NES":-1.1881,"nMoreExtreme":3480,"size":85,"leadingEdge":["IFT122","CELSR1","FZD3","PRKACB","IFT172","CC2D2A","SEMA4C","KAT2A","SKI","STIL","BMP4","KIF20B","SHROOM3"]} {"pathway":"GO_RIBONUCLEOPROTEIN_COMPLEX_SUBUNIT_ORGANIZATION","pval":0.0567,"padj":0.57014,"ES":-0.56437,"NES":-1.18948,"nMoreExtreme":604,"size":238,"leadingEdge":["TICRR"]} {"pathway":"GO_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR","pval":0.05228,"padj":0.55686,"ES":-0.56222,"NES":-1.19101,"nMoreExtreme":523,"size":251,"leadingEdge":["E2F2","E2F8","E2F1","EXO1","CDK1","BRCA1","GTSE1","AURKB","CDC25C","NUAK1","RFC3","TP73","RFC5","RFC4","DNA2","E2F7","FOXM1","CHEK1","TPX2","BCL2","DDIT4","BLM","SNAI1","CDK5R1","TP53INP1","PCNA","ATAD5","MSH2","TFAP4","PRKN","CDK2","FOXO3"]} {"pathway":"GO_AMP_METABOLIC_PROCESS","pval":0.55711,"padj":0.93517,"ES":-0.86215,"NES":-1.19212,"nMoreExtreme":25429,"size":7,"leadingEdge":["AK1"]} {"pathway":"GO_CEREBELLAR_CORTEX_FORMATION","pval":0.42813,"padj":0.89886,"ES":-0.90227,"NES":-1.19227,"nMoreExtreme":17372,"size":15,"leadingEdge":["DLL1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION","pval":0.2465,"padj":0.82387,"ES":-0.79206,"NES":-1.19287,"nMoreExtreme":8439,"size":32,"leadingEdge":["DAB2","TTK","GDF7","BMP6","BMP8A","BMP4","ENG","BMP2"]} {"pathway":"GO_CEREBELLAR_GRANULAR_LAYER_DEVELOPMENT","pval":0.55465,"padj":0.93396,"ES":-0.87806,"NES":-1.193,"nMoreExtreme":24904,"size":8,"leadingEdge":["KIF14"]} {"pathway":"GO_HETEROCHROMATIN_ORGANIZATION","pval":0.40804,"padj":0.89503,"ES":-0.89819,"NES":-1.1932,"nMoreExtreme":16361,"size":16,"leadingEdge":["HELLS","SNAI1"]} {"pathway":"GO_RESPONSE_TO_WATER","pval":0.51252,"padj":0.92419,"ES":-0.90685,"NES":-1.19372,"nMoreExtreme":21987,"size":11,"leadingEdge":["CD9"]} {"pathway":"GO_CEREBELLAR_CORTEX_DEVELOPMENT","pval":0.21756,"padj":0.80167,"ES":-0.76022,"NES":-1.19668,"nMoreExtreme":6978,"size":39,"leadingEdge":["DLL1","KIF14","SEZ6"]} {"pathway":"GO_ENDOCARDIUM_DEVELOPMENT","pval":0.52812,"padj":0.92669,"ES":-0.90393,"NES":-1.19844,"nMoreExtreme":23002,"size":10,"leadingEdge":["SOX17"]} {"pathway":"GO_REGULATION_OF_CYTOKINESIS","pval":0.15219,"padj":0.75292,"ES":-0.6698,"NES":-1.19883,"nMoreExtreme":3861,"size":72,"leadingEdge":["E2F8","CDC6","PRC1","AURKB","CIT","KIF14","E2F7","KIF20A","PLK1"]} {"pathway":"GO_REGULATION_OF_CELL_FATE_SPECIFICATION","pval":0.51,"padj":0.92397,"ES":-0.91098,"NES":-1.19916,"nMoreExtreme":21879,"size":11,"leadingEdge":["SOX17","FZD7","FGFR1"]} {"pathway":"GO_INHIBITORY_POSTSYNAPTIC_POTENTIAL","pval":0.46551,"padj":0.90644,"ES":-0.91222,"NES":-1.19946,"nMoreExtreme":19439,"size":13,"leadingEdge":["INSYN2A","NTSR1"]} {"pathway":"GO_PHOSPHATIDYLINOSITOL_DEPHOSPHORYLATION","pval":0.29362,"padj":0.85379,"ES":-0.85021,"NES":-1.19971,"nMoreExtreme":10766,"size":24,"leadingEdge":["INPP5A"]} {"pathway":"GO_DNA_CATABOLIC_PROCESS_ENDONUCLEOLYTIC","pval":0.27474,"padj":0.83769,"ES":-0.83633,"NES":-1.20053,"nMoreExtreme":9895,"size":26,"leadingEdge":["HMGB2"]} {"pathway":"GO_CELL_CYCLE_PHASE_TRANSITION","pval":0.00708,"padj":0.22014,"ES":-0.53483,"NES":-1.20112,"nMoreExtreme":19,"size":551,"leadingEdge":["CCNE2","IQGAP3","E2F8","E2F1","MCM10","RRM2","CDKN2C","TYMS","CDC45","CDC25A","CDC6","CLSPN","TICRR","MCM6","RECQL4","MCM7","MCM4","CDT1","MCM2","CDCA5","PKMYT1","CDK1","ANLN","DHFR","BRCA1","DTL","CCNA2","MAD2L1","ORC1","POLE2","GTSE1","NDC80","AURKB","MCM5","BUB1B","CENPF","WEE1","CDC25C","KANK2","TTK","MCM8","ESPL1","CIT","KIF14","ORC6","E2F7","JADE1","FOXM1","UBE2C","CTDSPL","POLA1","DLGAP5","PLK4","CCNB2","CHEK1","NEK2","TPX2","FBXO5","BCL2","BUB1","CDC20","POLE","TRIP13","BLM","PLK1","NEK10","CDKN2B","MCM3","XRCC3","FAM83D","TACC3","CENPE","CDKN3","CCNE1","NES","HMMR","CEP72","PCNA","RCC1","DONSON","TPD52L1","ATAD5","CDC7","RBL1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_PROLIFERATION","pval":0.48652,"padj":0.91689,"ES":-0.91343,"NES":-1.20115,"nMoreExtreme":20588,"size":12,"leadingEdge":["CXADR","TP73","RBP4","JARID2"]} {"pathway":"GO_ZINC_ION_TRANSMEMBRANE_TRANSPORT","pval":0.3657,"padj":0.89036,"ES":-0.89359,"NES":-1.20178,"nMoreExtreme":14320,"size":18,"leadingEdge":["SLC30A2","TMEM163"]} {"pathway":"GO_SUCCINATE_TRANSPORT","pval":0.47133,"padj":0.90863,"ES":-0.7989,"NES":-1.20196,"nMoreExtreme":22602,"size":4,"leadingEdge":["SLC25A10"]} {"pathway":"GO_DETECTION_OF_CALCIUM_ION","pval":0.52606,"padj":0.92669,"ES":-0.90675,"NES":-1.20217,"nMoreExtreme":22912,"size":10,"leadingEdge":["SYT1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PEPTIDE_HORMONE_SECRETION","pval":0.23704,"padj":0.82177,"ES":-0.79876,"NES":-1.20295,"nMoreExtreme":8115,"size":32,"leadingEdge":["GHRL","CRHBP","HADH","BMP8A","PRKN"]} {"pathway":"GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_UBIQUINOL_TO_CYTOCHROME_C","pval":0.45885,"padj":0.90517,"ES":-0.91502,"NES":-1.20314,"nMoreExtreme":19161,"size":13,"leadingEdge":["UQCC3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY","pval":0.40066,"padj":0.89503,"ES":-0.90572,"NES":-1.20321,"nMoreExtreme":16065,"size":16,"leadingEdge":["TESC"]} {"pathway":"GO_NUCLEOTIDE_SALVAGE","pval":0.45418,"padj":0.90517,"ES":-0.91592,"NES":-1.20432,"nMoreExtreme":18966,"size":13,"leadingEdge":["AMPD2"]} {"pathway":"GO_PROGRAMMED_CELL_DEATH_INVOLVED_IN_CELL_DEVELOPMENT","pval":0.54953,"padj":0.93134,"ES":-0.88789,"NES":-1.20636,"nMoreExtreme":24674,"size":8,"leadingEdge":["KITLG","BCL2"]} {"pathway":"GO_ATP_HYDROLYSIS_COUPLED_TRANSMEMBRANE_TRANSPORT","pval":0.2785,"padj":0.84118,"ES":-0.84758,"NES":-1.2068,"nMoreExtreme":10108,"size":25,"leadingEdge":["ATP6V0D2","ABCC4","FXYD2"]} {"pathway":"GO_REGULATION_OF_HIPPO_SIGNALING","pval":0.49138,"padj":0.91835,"ES":-0.91694,"NES":-1.20699,"nMoreExtreme":21080,"size":11,"leadingEdge":["MOB3B"]} {"pathway":"GO_NUCLEAR_PORE_ORGANIZATION","pval":0.42729,"padj":0.89886,"ES":-0.91682,"NES":-1.2073,"nMoreExtreme":17578,"size":14,"leadingEdge":["NDC1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ANION_TRANSMEMBRANE_TRANSPORT","pval":0.4368,"padj":0.90126,"ES":-0.91869,"NES":-1.20797,"nMoreExtreme":18240,"size":13,"leadingEdge":["THBS1","IRS2","RGS4"]} {"pathway":"GO_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION","pval":0.16767,"padj":0.77295,"ES":-0.70996,"NES":-1.21033,"nMoreExtreme":4771,"size":56,"leadingEdge":["TNFRSF21","CDK1","SLC45A3","DAB1","TP73","OLIG2","DLX1","TREM2","C5AR1"]} {"pathway":"GO_SYNAPTIC_VESICLE_CLUSTERING","pval":0.42212,"padj":0.89612,"ES":-0.9207,"NES":-1.21061,"nMoreExtreme":17627,"size":13,"leadingEdge":["SYNDIG1","NLGN2"]} {"pathway":"GO_CELL_JUNCTION_MAINTENANCE","pval":0.44375,"padj":0.90337,"ES":-0.92065,"NES":-1.21065,"nMoreExtreme":18778,"size":12,"leadingEdge":["NLGN2"]} {"pathway":"GO_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION","pval":0.25875,"padj":0.82758,"ES":-0.83599,"NES":-1.21074,"nMoreExtreme":9237,"size":27,"leadingEdge":["TNFRSF21","SLC45A3","TP73","OLIG2","DLX1"]} {"pathway":"GO_POSTSYNAPTIC_DENSITY_ASSEMBLY","pval":0.42111,"padj":0.89612,"ES":-0.92081,"NES":-1.21075,"nMoreExtreme":17585,"size":13,"leadingEdge":["LRRTM1","LRRC4B","IL1RAP","NLGN2"]} {"pathway":"GO_REGULATION_OF_METHYLATION_DEPENDENT_CHROMATIN_SILENCING","pval":0.47054,"padj":0.9079,"ES":-0.91981,"NES":-1.21077,"nMoreExtreme":20186,"size":11,"leadingEdge":["TET1"]} {"pathway":"GO_REGULATION_OF_WATER_LOSS_VIA_SKIN","pval":0.53915,"padj":0.92855,"ES":-0.9041,"NES":-1.21105,"nMoreExtreme":23785,"size":9,"leadingEdge":["STMN1"]} {"pathway":"GO_REGULATION_OF_AXONOGENESIS","pval":0.07491,"padj":0.63068,"ES":-0.59983,"NES":-1.21119,"nMoreExtreme":1151,"size":161,"leadingEdge":["EPHB3","NRP1","SEMA6B","FSTL4","PLXNA2","DAB1","SEMA3G","SEMA6C","TIAM1","CDK5R1","UST","SEMA4C"]} {"pathway":"GO_OXIDATIVE_DEMETHYLATION","pval":0.40748,"padj":0.89503,"ES":-0.9198,"NES":-1.21123,"nMoreExtreme":16763,"size":14,"leadingEdge":["TET1"]} {"pathway":"GO_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY","pval":0.14335,"padj":0.74253,"ES":-0.68054,"NES":-1.21167,"nMoreExtreme":3689,"size":70,"leadingEdge":["IFT122","GLIS2","PRKACB","RUNX2","IFT172","DISP1","EVC"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MELANOCYTE_DIFFERENTIATION","pval":0.51632,"padj":0.92482,"ES":-0.83164,"NES":-1.21198,"nMoreExtreme":24312,"size":5,"leadingEdge":["KITLG","BCL2"]} {"pathway":"GO_BUNDLE_OF_HIS_CELL_TO_PURKINJE_MYOCYTE_COMMUNICATION","pval":0.52013,"padj":0.9256,"ES":-0.91436,"NES":-1.21227,"nMoreExtreme":22654,"size":10,"leadingEdge":["GJA5","SCN5A"]} {"pathway":"GO_OLIGOSACCHARIDE_METABOLIC_PROCESS","pval":0.39887,"padj":0.89503,"ES":-0.92092,"NES":-1.21271,"nMoreExtreme":16409,"size":14,"leadingEdge":["GAL3ST4","ST6GAL2","ST8SIA2"]} {"pathway":"GO_N_GLYCAN_PROCESSING","pval":0.39887,"padj":0.89503,"ES":-0.92092,"NES":-1.21271,"nMoreExtreme":16409,"size":14,"leadingEdge":["MAN1C1","MGAT4A","ST8SIA2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_13_PRODUCTION","pval":0.51621,"padj":0.92482,"ES":-0.83227,"NES":-1.2129,"nMoreExtreme":24307,"size":5,"leadingEdge":["TNFRSF21"]} {"pathway":"GO_WATER_HOMEOSTASIS","pval":0.20584,"padj":0.79637,"ES":-0.77511,"NES":-1.2131,"nMoreExtreme":6665,"size":38,"leadingEdge":["STMN1","ADCY1","ADCY4","PRKACB"]} {"pathway":"GO_INNER_EAR_AUDITORY_RECEPTOR_CELL_DIFFERENTIATION","pval":0.30235,"padj":0.85863,"ES":-0.87387,"NES":-1.21348,"nMoreExtreme":11316,"size":22,"leadingEdge":["DLL1","SLC4A7","MYO7A","FGFR1","SLC9A3R1"]} {"pathway":"GO_LOCOMOTOR_RHYTHM","pval":0.51435,"padj":0.92459,"ES":-0.91537,"NES":-1.21361,"nMoreExtreme":22402,"size":10,"leadingEdge":["USP2","OPRL1"]} {"pathway":"GO_CHROMOSOME_ORGANIZATION_INVOLVED_IN_MEIOTIC_CELL_CYCLE","pval":0.19686,"padj":0.791,"ES":-0.76228,"NES":-1.2143,"nMoreExtreme":6231,"size":41,"leadingEdge":["CCNE2","MEIKIN","DMC1","NCAPH","BUB1B","RAD51","BUB1","NCAPD3","TRIP13","SMC4","SMC2","NCAPD2","CCNE1","NCAPH2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ORGANIC_ACID_TRANSPORT","pval":0.40092,"padj":0.89503,"ES":-0.92357,"NES":-1.21437,"nMoreExtreme":16742,"size":13,"leadingEdge":["THBS1","IRS2","RGS4"]} {"pathway":"GO_SEQUESTERING_OF_ZINC_ION","pval":0.54997,"padj":0.93134,"ES":-0.8791,"NES":-1.21555,"nMoreExtreme":25103,"size":7,"leadingEdge":["SLC30A2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT","pval":0.44243,"padj":0.90221,"ES":-0.92346,"NES":-1.21558,"nMoreExtreme":18980,"size":11,"leadingEdge":["FSTL4","NGEF","DNM3"]} {"pathway":"GO_REGULATION_OF_KETONE_BIOSYNTHETIC_PROCESS","pval":0.43739,"padj":0.90126,"ES":-0.92414,"NES":-1.21647,"nMoreExtreme":18764,"size":11,"leadingEdge":["BMP6","BMP2"]} {"pathway":"GO_ALDEHYDE_BIOSYNTHETIC_PROCESS","pval":0.43739,"padj":0.90126,"ES":-0.92414,"NES":-1.21647,"nMoreExtreme":18764,"size":11,"leadingEdge":["BMP6","BMP2"]} {"pathway":"GO_REGULATION_OF_RNA_POLYMERASE_II_TRANSCRIPTIONAL_PREINITIATION_COMPLEX_ASSEMBLY","pval":0.37119,"padj":0.89036,"ES":-0.9248,"NES":-1.21781,"nMoreExtreme":15270,"size":14,"leadingEdge":["WNT10B"]} {"pathway":"GO_DNA_STRAND_ELONGATION_INVOLVED_IN_DNA_REPLICATION","pval":0.3592,"padj":0.89036,"ES":-0.92637,"NES":-1.21988,"nMoreExtreme":14777,"size":14,"leadingEdge":["GINS2","GINS1","RFC3","RFC4","DNA2","POLA1","POLE","GINS3","GINS4","PCNA","POLD2","LIG1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ASTROCYTE_DIFFERENTIATION","pval":0.35467,"padj":0.88844,"ES":-0.92412,"NES":-1.22114,"nMoreExtreme":14391,"size":15,"leadingEdge":["TREM2","BMP2"]} {"pathway":"GO_AEROBIC_RESPIRATION","pval":0.12881,"padj":0.72213,"ES":-0.67632,"NES":-1.22174,"nMoreExtreme":3189,"size":76,"leadingEdge":["CAT"]} {"pathway":"GO_ANTERIOR_POSTERIOR_PATTERN_SPECIFICATION","pval":0.0716,"padj":0.62112,"ES":-0.61135,"NES":-1.22178,"nMoreExtreme":1176,"size":148,"leadingEdge":["SSBP3","PLXNA2","LRP5","XRCC2","CELSR1","SOX17","DLL1","WLS","PCSK6","KAT2A","CELSR2","SKI","BMP4"]} {"pathway":"GO_INTRACILIARY_RETROGRADE_TRANSPORT","pval":0.37636,"padj":0.89036,"ES":-0.92925,"NES":-1.22195,"nMoreExtreme":15926,"size":12,"leadingEdge":["IFT122","DYNC2H1"]} {"pathway":"GO_SYNAPTIC_TRANSMISSION_GABAERGIC","pval":0.25018,"padj":0.82469,"ES":-0.84376,"NES":-1.22198,"nMoreExtreme":8931,"size":27,"leadingEdge":["GABRA3","NISCH","GABRE"]} {"pathway":"GO_HAIR_FOLLICLE_MATURATION","pval":0.34932,"padj":0.88365,"ES":-0.92485,"NES":-1.22211,"nMoreExtreme":14174,"size":15,"leadingEdge":["MYO5A","WNT10B"]} {"pathway":"GO_REGULATION_OF_GLUCOSE_METABOLIC_PROCESS","pval":0.15028,"padj":0.75097,"ES":-0.70736,"NES":-1.22236,"nMoreExtreme":4134,"size":60,"leadingEdge":["PDK4","SLC45A3","INSR","KHK","PASK","IGFBP3","IRS2","PPP1R3G","PRKN"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION","pval":0.53477,"padj":0.92816,"ES":-0.91256,"NES":-1.22238,"nMoreExtreme":23592,"size":9,"leadingEdge":["TAL1","NCAPG2"]} {"pathway":"GO_SMAD_PROTEIN_SIGNAL_TRANSDUCTION","pval":0.17418,"padj":0.77529,"ES":-0.7413,"NES":-1.22239,"nMoreExtreme":5222,"size":48,"leadingEdge":["DAB2","ATOH8","GDF7","BMP6","SKI","BMP8A","BMP4","FOS","BMP2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_BONE_RESORPTION","pval":0.34545,"padj":0.88254,"ES":-0.92538,"NES":-1.22281,"nMoreExtreme":14017,"size":15,"leadingEdge":["TNFRSF11A","ADAM8","PRKCA","TNFSF11"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_NEUROTRANSMITTER_SECRETION","pval":0.36957,"padj":0.89036,"ES":-0.93003,"NES":-1.22299,"nMoreExtreme":15639,"size":12,"leadingEdge":["ASIC1","PRKN"]} {"pathway":"GO_CORONARY_VASCULATURE_MORPHOGENESIS","pval":0.34,"padj":0.87818,"ES":-0.92889,"NES":-1.2232,"nMoreExtreme":13987,"size":14,"leadingEdge":["NRP1","SGCD","TGFBR3"]} {"pathway":"GO_REGULATION_OF_POSTSYNAPTIC_SPECIALIZATION_ASSEMBLY","pval":0.46301,"padj":0.90517,"ES":-0.92262,"NES":-1.22322,"nMoreExtreme":20166,"size":10,"leadingEdge":["LRRTM1","LRRC4B","IL1RAP"]} {"pathway":"GO_ESTABLISHMENT_OR_MAINTENANCE_OF_MONOPOLAR_CELL_POLARITY","pval":0.35007,"padj":0.88493,"ES":-0.90961,"NES":-1.22334,"nMoreExtreme":13708,"size":18,"leadingEdge":["FSCN1","SLC9A3R1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION","pval":0.39357,"padj":0.89503,"ES":-0.92959,"NES":-1.22364,"nMoreExtreme":16884,"size":11,"leadingEdge":["E2F8","CDT1","E2F7","FGFR1","CDC7","CDK2"]} {"pathway":"GO_POLY_A_PLUS_MRNA_EXPORT_FROM_NUCLEUS","pval":0.33689,"padj":0.87637,"ES":-0.92924,"NES":-1.22366,"nMoreExtreme":13859,"size":14,"leadingEdge":["NXF3"]} {"pathway":"GO_ENDODERMAL_CELL_FATE_SPECIFICATION","pval":0.53846,"padj":0.92855,"ES":-0.8644,"NES":-1.22404,"nMoreExtreme":24947,"size":6,"leadingEdge":["SOX17"]} {"pathway":"GO_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_INVOLVED_IN_ENDOCARDIAL_CUSHION_FORMATION","pval":0.34321,"padj":0.88004,"ES":-0.93093,"NES":-1.22405,"nMoreExtreme":14332,"size":13,"leadingEdge":["SNAI1","ENG"]} {"pathway":"GO_AUTOCRINE_SIGNALING","pval":0.53844,"padj":0.92855,"ES":-0.86452,"NES":-1.22422,"nMoreExtreme":24946,"size":6,"leadingEdge":["CX3CR1"]} {"pathway":"GO_REGULATION_OF_I_KAPPAB_PHOSPHORYLATION","pval":0.53844,"padj":0.92855,"ES":-0.86452,"NES":-1.22422,"nMoreExtreme":24946,"size":6,"leadingEdge":["CX3CR1"]} {"pathway":"GO_PURINE_NUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS","pval":0.36094,"padj":0.89036,"ES":-0.9159,"NES":-1.22424,"nMoreExtreme":14282,"size":17,"leadingEdge":["AMPD2"]} {"pathway":"GO_HEART_VALVE_FORMATION","pval":0.36215,"padj":0.89036,"ES":-0.93099,"NES":-1.22425,"nMoreExtreme":15325,"size":12,"leadingEdge":["HEY1","GJA5"]} {"pathway":"GO_CELL_MIGRATION_IN_HINDBRAIN","pval":0.38933,"padj":0.89426,"ES":-0.9302,"NES":-1.22445,"nMoreExtreme":16702,"size":11,"leadingEdge":["PLXNA2","DAB1","SEMA4C"]} {"pathway":"GO_LYSINE_CATABOLIC_PROCESS","pval":0.388,"padj":0.89286,"ES":-0.93032,"NES":-1.22461,"nMoreExtreme":16645,"size":11,"leadingEdge":["ALDH7A1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION","pval":0.34707,"padj":0.88271,"ES":-0.92192,"NES":-1.22473,"nMoreExtreme":13916,"size":16,"leadingEdge":["DDIT4","SPRY2"]} {"pathway":"GO_PYRIMIDINE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORT","pval":0.54767,"padj":0.93115,"ES":-0.88579,"NES":-1.22481,"nMoreExtreme":24998,"size":7,"leadingEdge":["SLC28A3"]} {"pathway":"GO_NUCLEOBASE_TRANSPORT","pval":0.54767,"padj":0.93115,"ES":-0.88579,"NES":-1.22481,"nMoreExtreme":24998,"size":7,"leadingEdge":["SLC28A3"]} {"pathway":"GO_PURINE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORT","pval":0.54767,"padj":0.93115,"ES":-0.88579,"NES":-1.22481,"nMoreExtreme":24998,"size":7,"leadingEdge":["SLC28A3"]} {"pathway":"GO_MITRAL_VALVE_DEVELOPMENT","pval":0.38313,"padj":0.89036,"ES":-0.93094,"NES":-1.22542,"nMoreExtreme":16436,"size":11,"leadingEdge":["GJA5"]} {"pathway":"GO_REGULATION_OF_HELICASE_ACTIVITY","pval":0.32624,"padj":0.87041,"ES":-0.93059,"NES":-1.22544,"nMoreExtreme":13421,"size":14,"leadingEdge":["MCM2","MSH2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CALCINEURIN_MEDIATED_SIGNALING","pval":0.3262,"padj":0.87041,"ES":-0.93061,"NES":-1.22546,"nMoreExtreme":13419,"size":14,"leadingEdge":["MYOZ2","HOMER3"]} {"pathway":"GO_REGULATION_OF_SKELETAL_MUSCLE_ACETYLCHOLINE_GATED_CHANNEL_CLUSTERING","pval":0.51443,"padj":0.92459,"ES":-0.84095,"NES":-1.22554,"nMoreExtreme":24223,"size":5,"leadingEdge":["FZD9"]} {"pathway":"GO_CAMERA_TYPE_EYE_MORPHOGENESIS","pval":0.11913,"padj":0.70349,"ES":-0.67085,"NES":-1.2257,"nMoreExtreme":2861,"size":81,"leadingEdge":["IFT122","LRP5","DLL1","NECTIN1","RBP4","SKI","BMP4","THRB"]} {"pathway":"GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_III_ASSEMBLY","pval":0.52802,"padj":0.92669,"ES":-0.91504,"NES":-1.22571,"nMoreExtreme":23294,"size":9,"leadingEdge":["UQCC3"]} {"pathway":"GO_CIRCADIAN_SLEEP_WAKE_CYCLE","pval":0.44814,"padj":0.90517,"ES":-0.92456,"NES":-1.22578,"nMoreExtreme":19518,"size":10,"leadingEdge":["GHRL"]} {"pathway":"GO_CELL_MIGRATION_INVOLVED_IN_HEART_DEVELOPMENT","pval":0.32357,"padj":0.86974,"ES":-0.93098,"NES":-1.22595,"nMoreExtreme":13311,"size":14,"leadingEdge":["FLRT3","BMP4","ENG"]} {"pathway":"GO_POSITIVE_REGULATION_OF_RNA_POLYMERASE_II_TRANSCRIPTIONAL_PREINITIATION_COMPLEX_ASSEMBLY","pval":0.44609,"padj":0.90517,"ES":-0.92481,"NES":-1.22613,"nMoreExtreme":19429,"size":10,"leadingEdge":["WNT10B"]} {"pathway":"GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_DEVELOPMENT","pval":0.54305,"padj":0.93013,"ES":-0.90268,"NES":-1.22645,"nMoreExtreme":24383,"size":8,"leadingEdge":["CDK1","LMNA"]} {"pathway":"GO_RETINA_DEVELOPMENT_IN_CAMERA_TYPE_EYE","pval":0.09815,"padj":0.66591,"ES":-0.64551,"NES":-1.22668,"nMoreExtreme":2041,"size":104,"leadingEdge":["NRP1","LRP5","DLL1","MERTK","DLX1","RRM1","NECTIN1","RBP4","SKI"]} {"pathway":"GO_IMP_BIOSYNTHETIC_PROCESS","pval":0.52242,"padj":0.9256,"ES":-0.91594,"NES":-1.22691,"nMoreExtreme":23047,"size":9,"leadingEdge":["AMPD2"]} {"pathway":"GO_COENZYME_A_BIOSYNTHETIC_PROCESS","pval":0.44083,"padj":0.90126,"ES":-0.92549,"NES":-1.22702,"nMoreExtreme":19200,"size":10,"leadingEdge":["PANK1"]} {"pathway":"GO_NUCLEAR_PORE_COMPLEX_ASSEMBLY","pval":0.51677,"padj":0.92505,"ES":-0.91684,"NES":-1.22811,"nMoreExtreme":22798,"size":9,"leadingEdge":["NDC1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELL_CYCLE_CHECKPOINT","pval":0.51514,"padj":0.92459,"ES":-0.91713,"NES":-1.2285,"nMoreExtreme":22726,"size":9,"leadingEdge":["MAD2L1","NDC80","XRCC3"]} {"pathway":"GO_REGULATION_OF_POSTSYNAPTIC_MEMBRANE_NEUROTRANSMITTER_RECEPTOR_LEVELS","pval":0.15791,"padj":0.76265,"ES":-0.72688,"NES":-1.22888,"nMoreExtreme":4550,"size":54,"leadingEdge":["DNM1","LRRC7","DNM3"]} {"pathway":"GO_CARDIAC_MUSCLE_FIBER_DEVELOPMENT","pval":0.33096,"padj":0.87332,"ES":-0.93509,"NES":-1.22964,"nMoreExtreme":14005,"size":12,"leadingEdge":["CXADR","MYOM1","SGCD","BMP4","MYOM3"]} {"pathway":"GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_INVOLVED_IN_HEART_DEVELOPMENT","pval":0.31144,"padj":0.86489,"ES":-0.9352,"NES":-1.22967,"nMoreExtreme":13005,"size":13,"leadingEdge":["BMP4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_DIFFERENTIATION","pval":0.32876,"padj":0.87192,"ES":-0.93543,"NES":-1.23008,"nMoreExtreme":13912,"size":12,"leadingEdge":["CDH5","ATOH8","ETV2","BMP6","BMP4"]} {"pathway":"GO_RNA_STABILIZATION","pval":0.1821,"padj":0.7772,"ES":-0.76843,"NES":-1.23014,"nMoreExtreme":5722,"size":42,"leadingEdge":["SLC11A1","E2F1","DAZL"]} {"pathway":"GO_PURINE_NUCLEOSIDE_DIPHOSPHATE_BIOSYNTHETIC_PROCESS","pval":0.53697,"padj":0.92816,"ES":-0.86887,"NES":-1.23038,"nMoreExtreme":24878,"size":6,"leadingEdge":["AK1"]} {"pathway":"GO_ZINC_ION_TRANSPORT","pval":0.29925,"padj":0.85717,"ES":-0.89358,"NES":-1.2305,"nMoreExtreme":11300,"size":21,"leadingEdge":["SLC30A2","TMEM163"]} {"pathway":"GO_HISTONE_H4_K20_METHYLATION","pval":0.41815,"padj":0.89503,"ES":-0.9283,"NES":-1.23075,"nMoreExtreme":18212,"size":10,"leadingEdge":["BRCA1","KMT5C"]} {"pathway":"GO_EPHRIN_RECEPTOR_SIGNALING_PATHWAY","pval":0.11931,"padj":0.70349,"ES":-0.67844,"NES":-1.23119,"nMoreExtreme":2918,"size":78,"leadingEdge":["EPHB3","MMP9","SDC2","DNM1","ITSN1","AP2A2","TIAM1","CDK5R1","EFNB1","NGEF"]} {"pathway":"GO_CELL_FATE_SPECIFICATION","pval":0.1614,"padj":0.76656,"ES":-0.73777,"NES":-1.23215,"nMoreExtreme":4737,"size":51,"leadingEdge":["NRP1","SOX17","DLL1","OLIG2","FZD7","FGFR1","ETV2"]} {"pathway":"GO_SIGNAL_TRANSDUCTION_INVOLVED_IN_CELL_CYCLE_CHECKPOINT","pval":0.12735,"padj":0.72213,"ES":-0.69228,"NES":-1.23258,"nMoreExtreme":3277,"size":70,"leadingEdge":["E2F8","E2F1","CDK1","BRCA1","DTL","GTSE1","CDC25C","E2F7","CHEK1","PLK1"]} {"pathway":"GO_CELL_CELL_JUNCTION_MAINTENANCE","pval":0.48912,"padj":0.91689,"ES":-0.92066,"NES":-1.23323,"nMoreExtreme":21578,"size":9,"leadingEdge":["NLGN2"]} {"pathway":"GO_PRESYNAPTIC_MEMBRANE_ORGANIZATION","pval":0.48912,"padj":0.91689,"ES":-0.92066,"NES":-1.23323,"nMoreExtreme":21578,"size":9,"leadingEdge":["NLGN2"]} {"pathway":"GO_NEUTROPHIL_DIFFERENTIATION","pval":0.48499,"padj":0.91689,"ES":-0.92117,"NES":-1.23391,"nMoreExtreme":21396,"size":9,"leadingEdge":["CSF2"]} {"pathway":"GO_CARDIAC_CONDUCTION_SYSTEM_DEVELOPMENT","pval":0.39703,"padj":0.89503,"ES":-0.93094,"NES":-1.23425,"nMoreExtreme":17292,"size":10,"leadingEdge":["GJA5"]} {"pathway":"GO_REGULATION_OF_TRANSCRIPTION_INVOLVED_IN_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE","pval":0.23373,"padj":0.81652,"ES":-0.84518,"NES":-1.23482,"nMoreExtreme":8274,"size":28,"leadingEdge":["E2F1","RRM2","TYMS","CDC45","CDC6","CDT1","DHFR","ORC1","E2F7","POLA1","FBXO5","CCNE1","PCNA"]} {"pathway":"GO_PYRIMIDINE_NUCLEOTIDE_CATABOLIC_PROCESS","pval":0.27933,"padj":0.84181,"ES":-0.9397,"NES":-1.23558,"nMoreExtreme":11664,"size":13,"leadingEdge":["UNG","DUT"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC","pval":0.11075,"padj":0.69745,"ES":-0.67456,"NES":-1.23567,"nMoreExtreme":2647,"size":82,"leadingEdge":["CDC45","HELLS","ATAD2","JARID2"]} {"pathway":"GO_ESTABLISHMENT_OF_PIGMENT_GRANULE_LOCALIZATION","pval":0.27252,"padj":0.83739,"ES":-0.88328,"NES":-1.23626,"nMoreExtreme":10105,"size":23,"leadingEdge":["MYO7A","RAB17","MYO5A"]} {"pathway":"GO_REGULATION_OF_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE","pval":0.29285,"padj":0.85286,"ES":-0.94026,"NES":-1.23644,"nMoreExtreme":12392,"size":12,"leadingEdge":["SPAG5","NEK2","RACGAP1"]} {"pathway":"GO_NUCLEOSIDE_TRIPHOSPHATE_CATABOLIC_PROCESS","pval":0.31588,"padj":0.86619,"ES":-0.9397,"NES":-1.23696,"nMoreExtreme":13551,"size":11,"leadingEdge":["NUDT1","DUT"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_MICROTUBULE","pval":0.27998,"padj":0.84236,"ES":-0.93142,"NES":-1.23735,"nMoreExtreme":11226,"size":16,"leadingEdge":["KIF20B"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ANION_TRANSPORT","pval":0.31611,"padj":0.86619,"ES":-0.92016,"NES":-1.23752,"nMoreExtreme":12378,"size":18,"leadingEdge":["THBS1","GABRE","IRS2","RGS4"]} {"pathway":"GO_REGULATION_OF_STEROID_HORMONE_BIOSYNTHETIC_PROCESS","pval":0.46292,"padj":0.90517,"ES":-0.92414,"NES":-1.2379,"nMoreExtreme":20422,"size":9,"leadingEdge":["BMP6","BMP2"]} {"pathway":"GO_INNER_CELL_MASS_CELL_PROLIFERATION","pval":0.26546,"padj":0.83566,"ES":-0.94172,"NES":-1.23824,"nMoreExtreme":11085,"size":13,"leadingEdge":["NCAPG2","GINS1","GINS4"]} {"pathway":"GO_CIRCADIAN_SLEEP_WAKE_CYCLE_SLEEP","pval":0.45947,"padj":0.90517,"ES":-0.92456,"NES":-1.23845,"nMoreExtreme":20270,"size":9,"leadingEdge":["GHRL"]} {"pathway":"GO_POSITIVE_REGULATION_OF_RECEPTOR_INTERNALIZATION","pval":0.31095,"padj":0.86489,"ES":-0.9209,"NES":-1.23852,"nMoreExtreme":12176,"size":18,"leadingEdge":["NTF3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY","pval":0.30759,"padj":0.86308,"ES":-0.90819,"NES":-1.23976,"nMoreExtreme":11745,"size":20,"leadingEdge":["S1PR1","STMN1","ARHGAP6"]} {"pathway":"GO_MEMBRANOUS_SEPTUM_MORPHOGENESIS","pval":0.36319,"padj":0.89036,"ES":-0.93521,"NES":-1.23991,"nMoreExtreme":15818,"size":10,"leadingEdge":["BMP4"]} {"pathway":"GO_EMBRYONIC_BODY_MORPHOGENESIS","pval":0.29938,"padj":0.85717,"ES":-0.94195,"NES":-1.23992,"nMoreExtreme":12843,"size":11,"leadingEdge":["IFT122","GREM2"]} {"pathway":"GO_REGULATION_OF_CALCINEURIN_MEDIATED_SIGNALING","pval":0.20582,"padj":0.79637,"ES":-0.82367,"NES":-1.24047,"nMoreExtreme":7046,"size":32,"leadingEdge":["MYOZ2","AKAP6","HOMER3"]} {"pathway":"GO_CENTROSOME_DUPLICATION","pval":0.13155,"padj":0.72756,"ES":-0.71104,"NES":-1.2406,"nMoreExtreme":3546,"size":63,"leadingEdge":["BRCA1","CCNF","WDR62","PLK4","XRCC3","RTTN","KAT2A","CEP72","STIL","CDK2"]} {"pathway":"GO_MRNA_5_SPLICE_SITE_RECOGNITION","pval":0.44723,"padj":0.90517,"ES":-0.92617,"NES":-1.24061,"nMoreExtreme":19730,"size":9,"leadingEdge":["WEE2-AS1"]} {"pathway":"GO_PLATELET_MORPHOGENESIS","pval":0.28207,"padj":0.84486,"ES":-0.9282,"NES":-1.24067,"nMoreExtreme":11161,"size":17,"leadingEdge":["TAL1"]} {"pathway":"GO_NUCLEOLAR_LARGE_RRNA_TRANSCRIPTION_BY_RNA_POLYMERASE_I","pval":0.29111,"padj":0.85125,"ES":-0.94307,"NES":-1.2414,"nMoreExtreme":12488,"size":11,"leadingEdge":["DDX11"]} {"pathway":"GO_LABYRINTHINE_LAYER_BLOOD_VESSEL_DEVELOPMENT","pval":0.29672,"padj":0.85691,"ES":-0.9231,"NES":-1.24148,"nMoreExtreme":11619,"size":18,"leadingEdge":["PLCD3","HEY1"]} {"pathway":"GO_PYRIMIDINE_NUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS","pval":0.24192,"padj":0.82373,"ES":-0.93974,"NES":-1.24179,"nMoreExtreme":9816,"size":15,"leadingEdge":["TYMS","SHMT1","DUT"]} {"pathway":"GO_CONDITIONED_TASTE_AVERSION","pval":0.13446,"padj":0.72971,"ES":-0.93215,"NES":-1.24199,"nMoreExtreme":6717,"size":1,"leadingEdge":["FOS"]} {"pathway":"GO_ECTODERMAL_PLACODE_DEVELOPMENT","pval":0.28633,"padj":0.84868,"ES":-0.94379,"NES":-1.24233,"nMoreExtreme":12283,"size":11,"leadingEdge":["NRP1","EDA"]} {"pathway":"GO_KERATINOCYTE_DEVELOPMENT","pval":0.53545,"padj":0.92816,"ES":-0.91443,"NES":-1.24242,"nMoreExtreme":24042,"size":8,"leadingEdge":["BCL11B"]} {"pathway":"GO_TRACHEA_DEVELOPMENT","pval":0.2535,"padj":0.82744,"ES":-0.93524,"NES":-1.24243,"nMoreExtreme":10164,"size":16,"leadingEdge":["EDA","BMP4"]} {"pathway":"GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_RECEPTOR_BIOSYNTHETIC_PROCESS","pval":0.53501,"padj":0.92816,"ES":-0.91448,"NES":-1.24249,"nMoreExtreme":24022,"size":8,"leadingEdge":["ITGB3"]} {"pathway":"GO_MITOTIC_CHROMOSOME_CONDENSATION","pval":0.24953,"padj":0.82387,"ES":-0.93581,"NES":-1.24318,"nMoreExtreme":10005,"size":16,"leadingEdge":["NCAPG","CDCA5","NUSAP1","NCAPH","NCAPD3","SMC4","SMC2","NCAPD2","NCAPH2"]} {"pathway":"GO_CEREBELLAR_GRANULAR_LAYER_MORPHOGENESIS","pval":0.53404,"padj":0.92816,"ES":-0.87806,"NES":-1.24338,"nMoreExtreme":24742,"size":6,"leadingEdge":["KIF14"]} {"pathway":"GO_MITOCHONDRIAL_FUSION","pval":0.27769,"padj":0.84047,"ES":-0.89559,"NES":-1.24365,"nMoreExtreme":10393,"size":22,"leadingEdge":["PID1"]} {"pathway":"GO_FATTY_ACID_BETA_OXIDATION_USING_ACYL_COA_OXIDASE","pval":0.23081,"padj":0.81508,"ES":-0.94143,"NES":-1.24402,"nMoreExtreme":9365,"size":15,"leadingEdge":["ACOX2"]} {"pathway":"GO_PEPTIDYL_LYSINE_MONOMETHYLATION","pval":0.42627,"padj":0.89843,"ES":-0.92875,"NES":-1.24407,"nMoreExtreme":18805,"size":9,"leadingEdge":["SETD6"]} {"pathway":"GO_ATTACHMENT_OF_MITOTIC_SPINDLE_MICROTUBULES_TO_KINETOCHORE","pval":0.23177,"padj":0.81508,"ES":-0.94661,"NES":-1.24467,"nMoreExtreme":9678,"size":13,"leadingEdge":["CDT1","NUF2","NDC80","KIF2C","CENPE"]} {"pathway":"GO_NEUROBLAST_DIVISION","pval":0.24852,"padj":0.82387,"ES":-0.94656,"NES":-1.24472,"nMoreExtreme":10516,"size":12,"leadingEdge":["ASPM","FGFR1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CENTROSOME_CYCLE","pval":0.22425,"padj":0.8097,"ES":-0.94526,"NES":-1.24475,"nMoreExtreme":9225,"size":14,"leadingEdge":["BRCA1","CCNF","NEK2","KIF25","KAT2A"]} {"pathway":"GO_OOCYTE_MATURATION","pval":0.28794,"padj":0.84886,"ES":-0.90419,"NES":-1.24511,"nMoreExtreme":10873,"size":21,"leadingEdge":["DMC1","PDE3A","FBXO5","TRIP13"]} {"pathway":"GO_MANNOSE_METABOLIC_PROCESS","pval":0.52151,"padj":0.9256,"ES":-0.91673,"NES":-1.24555,"nMoreExtreme":23416,"size":8,"leadingEdge":["MPI"]} {"pathway":"GO_REGULATION_OF_HEXOKINASE_ACTIVITY","pval":0.41584,"padj":0.89503,"ES":-0.92999,"NES":-1.24573,"nMoreExtreme":18345,"size":9,"leadingEdge":["PRKN"]} {"pathway":"GO_UBIQUITIN_RECYCLING","pval":0.41552,"padj":0.89503,"ES":-0.93004,"NES":-1.2458,"nMoreExtreme":18331,"size":9,"leadingEdge":["UBE2C","PRKN"]} {"pathway":"GO_DEOXYRIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS","pval":0.32788,"padj":0.87134,"ES":-0.93982,"NES":-1.24602,"nMoreExtreme":14280,"size":10,"leadingEdge":["TYMS","TK1","SHMT1","DUT"]} {"pathway":"GO_REGULATION_OF_PROTON_TRANSPORT","pval":0.22036,"padj":0.80441,"ES":-0.943,"NES":-1.2461,"nMoreExtreme":8941,"size":15,"leadingEdge":["TESC","SLC9A3R1"]} {"pathway":"GO_LEFT_RIGHT_AXIS_SPECIFICATION","pval":0.2232,"padj":0.80675,"ES":-0.94796,"NES":-1.24645,"nMoreExtreme":9320,"size":13,"leadingEdge":["DLL1","MNS1","IFT172"]} {"pathway":"GO_POSITIVE_REGULATION_OF_HELICASE_ACTIVITY","pval":0.41115,"padj":0.89503,"ES":-0.93055,"NES":-1.24648,"nMoreExtreme":18138,"size":9,"leadingEdge":["MSH2"]} {"pathway":"GO_REGULATION_OF_CARDIAC_EPITHELIAL_TO_MESENCHYMAL_TRANSITION","pval":0.40877,"padj":0.89503,"ES":-0.93089,"NES":-1.24693,"nMoreExtreme":18033,"size":9,"leadingEdge":["ENG"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MITOCHONDRION","pval":0.14678,"padj":0.75023,"ES":-0.74082,"NES":-1.24702,"nMoreExtreme":4255,"size":53,"leadingEdge":["ABLIM3","E2F1","TP73","BCL2"]} {"pathway":"GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CENTROSOME","pval":0.3223,"padj":0.86953,"ES":-0.9406,"NES":-1.24706,"nMoreExtreme":14037,"size":10,"leadingEdge":["CEP72"]} {"pathway":"GO_ESTROGEN_BIOSYNTHETIC_PROCESS","pval":0.32143,"padj":0.86901,"ES":-0.94072,"NES":-1.24721,"nMoreExtreme":13999,"size":10,"leadingEdge":["CYP19A1","DHRS11"]} {"pathway":"GO_UV_PROTECTION","pval":0.21721,"padj":0.80167,"ES":-0.94886,"NES":-1.24763,"nMoreExtreme":9070,"size":13,"leadingEdge":["FEN1","CAT"]} {"pathway":"GO_REGULATION_OF_AMYLOID_BETA_CLEARANCE","pval":0.21604,"padj":0.80167,"ES":-0.94902,"NES":-1.24785,"nMoreExtreme":9021,"size":13,"leadingEdge":["TREM2","C5AR1"]} {"pathway":"GO_AV_NODE_CELL_TO_BUNDLE_OF_HIS_CELL_COMMUNICATION","pval":0.40092,"padj":0.89503,"ES":-0.93193,"NES":-1.24832,"nMoreExtreme":17687,"size":9,"leadingEdge":["SCN4B","CXADR","GJC1"]} {"pathway":"GO_MAST_CELL_DIFFERENTIATION","pval":0.46657,"padj":0.90732,"ES":-0.82973,"NES":-1.24834,"nMoreExtreme":22374,"size":4,"leadingEdge":["TAL1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_KERATINOCYTE_PROLIFERATION","pval":0.31367,"padj":0.86489,"ES":-0.94167,"NES":-1.24848,"nMoreExtreme":13661,"size":10,"leadingEdge":["CD109"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_PRODUCTION","pval":0.39592,"padj":0.89503,"ES":-0.93257,"NES":-1.24919,"nMoreExtreme":17466,"size":9,"leadingEdge":["CD24"]} {"pathway":"GO_REGULATION_OF_SPINDLE_CHECKPOINT","pval":0.209,"padj":0.79637,"ES":-0.95009,"NES":-1.24925,"nMoreExtreme":8727,"size":13,"leadingEdge":["CDT1","MAD2L1","NDC80","XRCC3"]} {"pathway":"GO_NEURON_RECOGNITION","pval":0.18202,"padj":0.7772,"ES":-0.80759,"NES":-1.24935,"nMoreExtreme":6008,"size":36,"leadingEdge":["PCDH12","EPHB3","NRP1","TNFRSF21","CDK5R1"]} {"pathway":"GO_CELL_ADHESION_MOLECULE_PRODUCTION","pval":0.50125,"padj":0.91978,"ES":-0.91976,"NES":-1.24966,"nMoreExtreme":22506,"size":8,"leadingEdge":["COLEC12"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_DNA_DAMAGE_STIMULUS","pval":0.00192,"padj":0.0971,"ES":-0.54683,"NES":-1.24996,"nMoreExtreme":1,"size":788,"leadingEdge":["E2F8","TOP2A","E2F1","MCM10","GINS2","ARMT1","CDC45","RAD54L","PCLAF","CLSPN","TICRR","RECQL4","MCM7","EXO1","EEPD1","ESCO2","DMC1","FEN1","CDCA5","CDK1","XRCC2","BRCA1","DTL","NEIL3","WDR76","CHAF1B","POLE2","UHRF1","GTSE1","UBE2T","UNG","EME1","FANCE","TONSL","POLQ","CDC25C","NUAK1","RFC3","TP73","MCM8","RFC5","AUNIP","RFC4","RAD51","DNA2","MAP2K6","FANCB","E2F7","MMS22L","FOXM1","WDHD1","FANCG","CHAF1A","FANCI","PARP2","POLA1","CHEK1","FBXO5","BCL2","HMGB2","POLE","TRIP13","DDIT4","BLM","PLK1","SLF1","SNAI1","CIDEB","CENPS","RAD51AP1","ACKR3","IER3","NUDT1","XRCC3","SPATA18","DDX11","GINS4","PCNA","USP51","RBM24","DONSON","DDIAS","ATAD5","CDC7","KIF22"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION","pval":0.23499,"padj":0.81912,"ES":-0.93524,"NES":-1.25009,"nMoreExtreme":9298,"size":17,"leadingEdge":["RFLNB","BMP4"]} {"pathway":"GO_TELOMERIC_LOOP_DISASSEMBLY","pval":0.24132,"padj":0.82358,"ES":-0.95004,"NES":-1.25057,"nMoreExtreme":10352,"size":11,"leadingEdge":["RECQL4","BLM","XRCC3"]} {"pathway":"GO_POSTSYNAPTIC_MEMBRANE_ASSEMBLY","pval":0.49405,"padj":0.91907,"ES":-0.92067,"NES":-1.25089,"nMoreExtreme":22183,"size":8,"leadingEdge":["NLGN2"]} {"pathway":"GO_REGULATION_OF_SYNAPTIC_VESICLE_CLUSTERING","pval":0.49405,"padj":0.91907,"ES":-0.92067,"NES":-1.25089,"nMoreExtreme":22183,"size":8,"leadingEdge":["NLGN2"]} {"pathway":"GO_KINETOCHORE_ASSEMBLY","pval":0.2112,"padj":0.79831,"ES":-0.94165,"NES":-1.25094,"nMoreExtreme":8468,"size":16,"leadingEdge":["CENPK","CENPF","CENPA","CENPH","CENPS","CENPE","CENPN"]} {"pathway":"GO_RESPONSE_TO_MORPHINE","pval":0.27465,"padj":0.83769,"ES":-0.92343,"NES":-1.25107,"nMoreExtreme":10596,"size":19,"leadingEdge":["RGS4"]} {"pathway":"GO_PHOSPHATIDYLETHANOLAMINE_BIOSYNTHETIC_PROCESS","pval":0.1993,"padj":0.79183,"ES":-0.95167,"NES":-1.25132,"nMoreExtreme":8322,"size":13,"leadingEdge":["ALOX15"]} {"pathway":"GO_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_ASSEMBLY","pval":0.23388,"padj":0.81652,"ES":-0.95128,"NES":-1.2522,"nMoreExtreme":10033,"size":11,"leadingEdge":["PRKACB"]} {"pathway":"GO_MYOSIN_FILAMENT_ORGANIZATION","pval":0.37724,"padj":0.89036,"ES":-0.93493,"NES":-1.25235,"nMoreExtreme":16642,"size":9,"leadingEdge":["MYOM1","MYOM3"]} {"pathway":"GO_REGULATION_OF_MESODERM_DEVELOPMENT","pval":0.29234,"padj":0.85228,"ES":-0.94465,"NES":-1.25242,"nMoreExtreme":12732,"size":10,"leadingEdge":["SOX17","FGFR1","ETV2"]} {"pathway":"GO_MESODERMAL_CELL_FATE_SPECIFICATION","pval":0.29234,"padj":0.85228,"ES":-0.94465,"NES":-1.25242,"nMoreExtreme":12732,"size":10,"leadingEdge":["SOX17","FGFR1","ETV2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_STIMULUS","pval":0.48423,"padj":0.91689,"ES":-0.92196,"NES":-1.25264,"nMoreExtreme":21742,"size":8,"leadingEdge":["ADGRA2","SPRY2"]} {"pathway":"GO_REGULATION_OF_PEROXISOME_PROLIFERATOR_ACTIVATED_RECEPTOR_SIGNALING_PATHWAY","pval":0.23139,"padj":0.81508,"ES":-0.95167,"NES":-1.25271,"nMoreExtreme":9926,"size":11,"leadingEdge":["ALOX15"]} {"pathway":"GO_EMBRYONIC_SKELETAL_JOINT_DEVELOPMENT","pval":0.37518,"padj":0.89036,"ES":-0.93521,"NES":-1.25273,"nMoreExtreme":16551,"size":9,"leadingEdge":["BMP4"]} {"pathway":"GO_SEROTONIN_RECEPTOR_SIGNALING_PATHWAY","pval":0.37518,"padj":0.89036,"ES":-0.93521,"NES":-1.25273,"nMoreExtreme":16551,"size":9,"leadingEdge":["HRH2","HTR2B","HRH1","CHRM3"]} {"pathway":"GO_EPITHELIAL_CELL_PROLIFERATION_INVOLVED_IN_LUNG_MORPHOGENESIS","pval":0.37518,"padj":0.89036,"ES":-0.93521,"NES":-1.25273,"nMoreExtreme":16551,"size":9,"leadingEdge":["BMP4"]} {"pathway":"GO_CARDIAC_NEURAL_CREST_CELL_DIFFERENTIATION_INVOLVED_IN_HEART_DEVELOPMENT","pval":0.37518,"padj":0.89036,"ES":-0.93521,"NES":-1.25273,"nMoreExtreme":16551,"size":9,"leadingEdge":["BMP4"]} {"pathway":"GO_MYELIN_MAINTENANCE","pval":0.20646,"padj":0.79637,"ES":-0.95302,"NES":-1.25322,"nMoreExtreme":8736,"size":12,"leadingEdge":["SH3TC2"]} {"pathway":"GO_PHOSPHORYLATED_CARBOHYDRATE_DEPHOSPHORYLATION","pval":0.18593,"padj":0.77996,"ES":-0.94868,"NES":-1.2536,"nMoreExtreme":7544,"size":15,"leadingEdge":["G6PC","INPP5A","IMPA2"]} {"pathway":"GO_EPITHELIAL_CELL_FATE_COMMITMENT","pval":0.22621,"padj":0.81244,"ES":-0.95247,"NES":-1.25377,"nMoreExtreme":9704,"size":11,"leadingEdge":["NRP1","DLL1"]} {"pathway":"GO_DNA_RECOMBINATION","pval":0.02624,"padj":0.40796,"ES":-0.59495,"NES":-1.25393,"nMoreExtreme":279,"size":238,"leadingEdge":["TOP2A","CD28","GINS2","CDC45","RAD54L","RECQL4","EXO1","DMC1","FEN1","XRCC2","BRCA1","UNG","EME1","TONSL","POLQ","MND1","MCM8","AUNIP","RAD51","FANCB","MMS22L","CHEK1","PSMC3IP","HMGB2","TRIP13","BLM","HMGB3","CENPS","RAD51AP1","XRCC3","GINS4","USP51","ATAD5","CDC7"]} {"pathway":"GO_PURINE_NUCLEOBASE_TRANSPORT","pval":0.53158,"padj":0.92816,"ES":-0.8858,"NES":-1.25434,"nMoreExtreme":24628,"size":6,"leadingEdge":["SLC28A3"]} {"pathway":"GO_RESOLUTION_OF_MEIOTIC_RECOMBINATION_INTERMEDIATES","pval":0.18498,"padj":0.77988,"ES":-0.95397,"NES":-1.25435,"nMoreExtreme":7724,"size":13,"leadingEdge":["TOP2A","EME1","BLM","CENPS"]} {"pathway":"GO_HAIR_CELL_DIFFERENTIATION","pval":0.23182,"padj":0.81508,"ES":-0.87386,"NES":-1.25439,"nMoreExtreme":8349,"size":26,"leadingEdge":["DLL1","SLC4A7","MYO7A","FGFR1","SLC9A3R1"]} {"pathway":"GO_LATERAL_MESODERM_DEVELOPMENT","pval":0.27831,"padj":0.84118,"ES":-0.9465,"NES":-1.25488,"nMoreExtreme":12121,"size":10,"leadingEdge":["FGFR1"]} {"pathway":"GO_TELOMERE_MAINTENANCE_VIA_RECOMBINATION","pval":0.178,"padj":0.77529,"ES":-0.94997,"NES":-1.25531,"nMoreExtreme":7222,"size":15,"leadingEdge":["RAD51","XRCC3"]} {"pathway":"GO_REGULATION_OF_GLUCOCORTICOID_METABOLIC_PROCESS","pval":0.46869,"padj":0.90755,"ES":-0.92409,"NES":-1.25555,"nMoreExtreme":21044,"size":8,"leadingEdge":["BMP2"]} {"pathway":"GO_WNT_SIGNALING_PATHWAY_INVOLVED_IN_HEART_DEVELOPMENT","pval":0.46831,"padj":0.90738,"ES":-0.92415,"NES":-1.25562,"nMoreExtreme":21027,"size":8,"leadingEdge":["SOX17","BMP2"]} {"pathway":"GO_PRIMARY_ALCOHOL_BIOSYNTHETIC_PROCESS","pval":0.46831,"padj":0.90738,"ES":-0.92415,"NES":-1.25562,"nMoreExtreme":21027,"size":8,"leadingEdge":["BMP6","BMP2"]} {"pathway":"GO_SEMAPHORIN_PLEXIN_SIGNALING_PATHWAY_INVOLVED_IN_NEURON_PROJECTION_GUIDANCE","pval":0.17643,"padj":0.77529,"ES":-0.95551,"NES":-1.25637,"nMoreExtreme":7367,"size":13,"leadingEdge":["NRP1","PLXNA2"]} {"pathway":"GO_REPLICATION_FORK_PROTECTION","pval":0.35371,"padj":0.88803,"ES":-0.93797,"NES":-1.25641,"nMoreExtreme":15604,"size":9,"leadingEdge":["BLM","DONSON"]} {"pathway":"GO_BIOLOGICAL_PHASE","pval":0.46276,"padj":0.90517,"ES":-0.92482,"NES":-1.25654,"nMoreExtreme":20778,"size":8,"leadingEdge":["WNT10B"]} {"pathway":"GO_ACTIVATION_OF_PROTEIN_KINASE_A_ACTIVITY","pval":0.17031,"padj":0.77295,"ES":-0.95138,"NES":-1.25717,"nMoreExtreme":6910,"size":15,"leadingEdge":["ADCY1","ADCY4","PRKACB"]} {"pathway":"GO_PIGMENT_GRANULE_LOCALIZATION","pval":0.23649,"padj":0.8216,"ES":-0.88327,"NES":-1.25761,"nMoreExtreme":8583,"size":25,"leadingEdge":["MYO7A","RAB17","MYO5A"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TORC1_SIGNALING","pval":0.18015,"padj":0.77529,"ES":-0.94683,"NES":-1.25782,"nMoreExtreme":7223,"size":16,"leadingEdge":["CASTOR1","SESN3","SESN1","RNF152"]} {"pathway":"GO_MEIOTIC_CHROMOSOME_SEPARATION","pval":0.21396,"padj":0.7999,"ES":-0.93574,"NES":-1.25848,"nMoreExtreme":8378,"size":18,"leadingEdge":["TOP2A","NCAPH","EME1","TTK","ESPL1","BLM","CENPS","NCAPH2"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_KINETOCHORE","pval":0.19483,"padj":0.79001,"ES":-0.94173,"NES":-1.25877,"nMoreExtreme":7709,"size":17,"leadingEdge":["CDT1","CDK1","NDC80","AURKB","HASPIN","TTK","KNL1"]} {"pathway":"GO_MODIFICATION_OF_POSTSYNAPTIC_STRUCTURE","pval":0.16511,"padj":0.76992,"ES":-0.95746,"NES":-1.25893,"nMoreExtreme":6894,"size":13,"leadingEdge":["CTTNBP2","TIAM1"]} {"pathway":"GO_PHOSPHATIDYLINOSITOL_3_PHOSPHATE_BIOSYNTHETIC_PROCESS","pval":0.16427,"padj":0.76986,"ES":-0.95762,"NES":-1.25916,"nMoreExtreme":6859,"size":13,"leadingEdge":["INPP4B","PIK3C2B"]} {"pathway":"GO_HISTONE_H3_K9_TRIMETHYLATION","pval":0.16122,"padj":0.76656,"ES":-0.95301,"NES":-1.25932,"nMoreExtreme":6541,"size":15,"leadingEdge":["SUV39H2","LMNA"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NON_CANONICAL_WNT_SIGNALING_PATHWAY","pval":0.17789,"padj":0.77529,"ES":-0.95772,"NES":-1.25939,"nMoreExtreme":7527,"size":12,"leadingEdge":["DAB2"]} {"pathway":"GO_REGULATION_OF_DEOXYRIBONUCLEASE_ACTIVITY","pval":0.33506,"padj":0.87575,"ES":-0.9405,"NES":-1.2598,"nMoreExtreme":14781,"size":9,"leadingEdge":["DDX11","PCNA"]} {"pathway":"GO_POSITIVE_REGULATION_OF_I_KAPPAB_PHOSPHORYLATION","pval":0.50897,"padj":0.92347,"ES":-0.86452,"NES":-1.2599,"nMoreExtreme":23966,"size":5,"leadingEdge":["CX3CR1"]} {"pathway":"GO_SERINE_PHOSPHORYLATION_OF_STAT_PROTEIN","pval":0.19533,"padj":0.79001,"ES":-0.95724,"NES":-1.26004,"nMoreExtreme":8379,"size":11,"leadingEdge":["CDK5R1"]} {"pathway":"GO_LAYER_FORMATION_IN_CEREBRAL_CORTEX","pval":0.19496,"padj":0.79001,"ES":-0.95729,"NES":-1.26011,"nMoreExtreme":8363,"size":11,"leadingEdge":["ADGRG1","CDK5R1"]} {"pathway":"GO_INOSITOL_PHOSPHATE_CATABOLIC_PROCESS","pval":0.17023,"padj":0.77295,"ES":-0.94868,"NES":-1.26028,"nMoreExtreme":6825,"size":16,"leadingEdge":["INPP5A","NTSR1","IMPA2"]} {"pathway":"GO_SYNAPTIC_VESICLE_BUDDING","pval":0.44098,"padj":0.90126,"ES":-0.92768,"NES":-1.26041,"nMoreExtreme":19800,"size":8,"leadingEdge":["DNM1"]} {"pathway":"GO_REGULATION_OF_WNT_SIGNALING_PATHWAY_PLANAR_CELL_POLARITY_PATHWAY","pval":0.15175,"padj":0.75292,"ES":-0.95771,"NES":-1.26116,"nMoreExtreme":6242,"size":14,"leadingEdge":["DAB2"]} {"pathway":"GO_HEART_TRABECULA_FORMATION","pval":0.24336,"padj":0.82387,"ES":-0.95145,"NES":-1.26144,"nMoreExtreme":10599,"size":10,"leadingEdge":["TGFBR3","HEY1","RBP4"]} {"pathway":"GO_B_CELL_PROLIFERATION_INVOLVED_IN_IMMUNE_RESPONSE","pval":0.50865,"padj":0.9232,"ES":-0.86568,"NES":-1.26158,"nMoreExtreme":23951,"size":5,"leadingEdge":["GAPT","CD180"]} {"pathway":"GO_EXTRACELLULAR_REGULATION_OF_SIGNAL_TRANSDUCTION","pval":0.3242,"padj":0.86994,"ES":-0.9419,"NES":-1.26168,"nMoreExtreme":14302,"size":9,"leadingEdge":["GREM2"]} {"pathway":"GO_REGULATION_OF_LOW_DENSITY_LIPOPROTEIN_PARTICLE_CLEARANCE","pval":0.4327,"padj":0.90066,"ES":-0.9287,"NES":-1.26181,"nMoreExtreme":19428,"size":8,"leadingEdge":["IL19"]} {"pathway":"GO_SPERM_AXONEME_ASSEMBLY","pval":0.24086,"padj":0.82355,"ES":-0.95184,"NES":-1.26196,"nMoreExtreme":10490,"size":10,"leadingEdge":["CFAP44"]} {"pathway":"GO_LOCOMOTION_INVOLVED_IN_LOCOMOTORY_BEHAVIOR","pval":0.43089,"padj":0.89981,"ES":-0.92892,"NES":-1.26211,"nMoreExtreme":19347,"size":8,"leadingEdge":["MYO5A"]} {"pathway":"GO_ACTIN_FILAMENT_BASED_TRANSPORT","pval":0.43031,"padj":0.89981,"ES":-0.92898,"NES":-1.26219,"nMoreExtreme":19321,"size":8,"leadingEdge":["FNBP1L","MYO5A"]} {"pathway":"GO_CENTROSOME_SEPARATION","pval":0.15023,"padj":0.75097,"ES":-0.9552,"NES":-1.26222,"nMoreExtreme":6095,"size":15,"leadingEdge":["KIF11","CHEK1","NEK2","KIF25"]} {"pathway":"GO_MITOTIC_NUCLEAR_ENVELOPE_DISASSEMBLY","pval":0.16404,"padj":0.76986,"ES":-0.96,"NES":-1.26239,"nMoreExtreme":6941,"size":12,"leadingEdge":["CDK1","PRKCA","CCNB2","PLK1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION","pval":0.18318,"padj":0.77986,"ES":-0.9592,"NES":-1.26263,"nMoreExtreme":7858,"size":11,"leadingEdge":["LDLRAD4"]} {"pathway":"GO_SIGNAL_TRANSDUCTION_INVOLVED_IN_G2_DNA_DAMAGE_CHECKPOINT","pval":0.14765,"padj":0.7508,"ES":-0.96066,"NES":-1.26315,"nMoreExtreme":6165,"size":13,"leadingEdge":["BRCA1","DTL","CHEK1","PLK1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_OF_NUCLEOLAR_LARGE_RRNA_BY_RNA_POLYMERASE_I","pval":0.3154,"padj":0.86578,"ES":-0.94308,"NES":-1.26326,"nMoreExtreme":13914,"size":9,"leadingEdge":["DDX11"]} {"pathway":"GO_RESPONSE_TO_HYDROXYUREA","pval":0.31497,"padj":0.86511,"ES":-0.94314,"NES":-1.26334,"nMoreExtreme":13895,"size":9,"leadingEdge":["BLM","DDX11"]} {"pathway":"GO_CENTROMERIC_SISTER_CHROMATID_COHESION","pval":0.16021,"padj":0.76421,"ES":-0.96077,"NES":-1.26341,"nMoreExtreme":6779,"size":12,"leadingEdge":["MEIKIN","BUB1B","SGO1","BUB1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SISTER_CHROMATID_COHESION","pval":0.31472,"padj":0.86509,"ES":-0.94319,"NES":-1.26341,"nMoreExtreme":13884,"size":9,"leadingEdge":["FEN1","SLF1","DDX11"]} {"pathway":"GO_REGULATION_OF_HISTONE_H3_K9_TRIMETHYLATION","pval":0.23319,"padj":0.81557,"ES":-0.95297,"NES":-1.26345,"nMoreExtreme":10156,"size":10,"leadingEdge":["LMNA"]} {"pathway":"GO_MAINTENANCE_OF_SISTER_CHROMATID_COHESION","pval":0.17897,"padj":0.77529,"ES":-0.95988,"NES":-1.26351,"nMoreExtreme":7677,"size":11,"leadingEdge":["DSCC1","SLF1"]} {"pathway":"GO_ENDOSOME_TO_PLASMA_MEMBRANE_PROTEIN_TRANSPORT","pval":0.23037,"padj":0.81508,"ES":-0.95342,"NES":-1.26405,"nMoreExtreme":10033,"size":10,"leadingEdge":["LRRC7"]} {"pathway":"GO_PROTEIN_K6_LINKED_UBIQUITINATION","pval":0.41724,"padj":0.89503,"ES":-0.93061,"NES":-1.26441,"nMoreExtreme":18734,"size":8,"leadingEdge":["BRCA1","UBE2T"]} {"pathway":"GO_POSITIVE_REGULATION_OF_UBIQUITIN_PROTEIN_LIGASE_ACTIVITY","pval":0.17472,"padj":0.77529,"ES":-0.96061,"NES":-1.26448,"nMoreExtreme":7495,"size":11,"leadingEdge":["UBE2C","CDC20","PLK1"]} {"pathway":"GO_POLYSACCHARIDE_METABOLIC_PROCESS","pval":0.08535,"padj":0.65271,"ES":-0.68133,"NES":-1.26512,"nMoreExtreme":1959,"size":89,"leadingEdge":["PCDH12","G6PC","INSR","KHK","PASK","CHST7","IRS2","PPP1R3G"]} {"pathway":"GO_CELL_PROLIFERATION_IN_FOREBRAIN","pval":0.16769,"padj":0.77295,"ES":-0.9466,"NES":-1.26526,"nMoreExtreme":6635,"size":17,"leadingEdge":["KIF14","RRM1","FGFR1"]} {"pathway":"GO_ECTOPIC_GERM_CELL_PROGRAMMED_CELL_DEATH","pval":0.52914,"padj":0.92669,"ES":-0.89358,"NES":-1.26537,"nMoreExtreme":24515,"size":6,"leadingEdge":["KITLG"]} {"pathway":"GO_OVULATION_FROM_OVARIAN_FOLLICLE","pval":0.53032,"padj":0.92803,"ES":-0.91516,"NES":-1.26542,"nMoreExtreme":24206,"size":7,"leadingEdge":["FOXO3","AFP"]} {"pathway":"GO_INNER_CELL_MASS_CELL_DIFFERENTIATION","pval":0.52912,"padj":0.92669,"ES":-0.89381,"NES":-1.26569,"nMoreExtreme":24514,"size":6,"leadingEdge":["SOX17"]} {"pathway":"GO_REGULATION_OF_GASTRIC_ACID_SECRETION","pval":0.52892,"padj":0.92669,"ES":-0.91539,"NES":-1.26573,"nMoreExtreme":24142,"size":7,"leadingEdge":["PTGER3","OPRL1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CHROMATIN_SILENCING","pval":0.40914,"padj":0.89503,"ES":-0.9317,"NES":-1.26588,"nMoreExtreme":18370,"size":8,"leadingEdge":["ATAD2"]} {"pathway":"GO_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS_BY_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER","pval":0.30124,"padj":0.85813,"ES":-0.94505,"NES":-1.2659,"nMoreExtreme":13289,"size":9,"leadingEdge":["KAT2A"]} {"pathway":"GO_ADP_BIOSYNTHETIC_PROCESS","pval":0.50789,"padj":0.92265,"ES":-0.86887,"NES":-1.26624,"nMoreExtreme":23915,"size":5,"leadingEdge":["AK1"]} {"pathway":"GO_REGULATION_OF_INCLUSION_BODY_ASSEMBLY","pval":0.13413,"padj":0.72971,"ES":-0.95835,"NES":-1.26638,"nMoreExtreme":5442,"size":15,"leadingEdge":["SORL1"]} {"pathway":"GO_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS","pval":0.40419,"padj":0.89503,"ES":-0.93235,"NES":-1.26677,"nMoreExtreme":18148,"size":8,"leadingEdge":["HBEGF","PTX3"]} {"pathway":"GO_PHOSPHOLIPID_EFFLUX","pval":0.52292,"padj":0.92589,"ES":-0.91634,"NES":-1.26705,"nMoreExtreme":23868,"size":7,"leadingEdge":["APOC1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_LIPOPROTEIN_PARTICLE_CLEARANCE","pval":0.5225,"padj":0.9256,"ES":-0.9164,"NES":-1.26713,"nMoreExtreme":23849,"size":7,"leadingEdge":["IL19","APOC1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY","pval":0.22108,"padj":0.80586,"ES":-0.88274,"NES":-1.26714,"nMoreExtreme":7962,"size":26,"leadingEdge":["IFT122","GLIS2","PRKACB","RUNX2"]} {"pathway":"GO_REGULATION_OF_STEM_CELL_DIVISION","pval":0.29367,"padj":0.85379,"ES":-0.9461,"NES":-1.2673,"nMoreExtreme":12955,"size":9,"leadingEdge":["LBH","SOX17"]} {"pathway":"GO_CELL_PROLIFERATION_IN_MIDBRAIN","pval":0.52873,"padj":0.92669,"ES":-0.89508,"NES":-1.26749,"nMoreExtreme":24496,"size":6,"leadingEdge":["FZD3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_EXCITATORY_POSTSYNAPTIC_POTENTIAL","pval":0.24933,"padj":0.82387,"ES":-0.92078,"NES":-1.26796,"nMoreExtreme":9415,"size":21,"leadingEdge":["STX1A","CUX2","RGS4","NLGN2"]} {"pathway":"GO_HEPOXILIN_BIOSYNTHETIC_PROCESS","pval":0.09571,"padj":0.66591,"ES":-0.9517,"NES":-1.26803,"nMoreExtreme":4781,"size":1,"leadingEdge":["ALOX15"]} {"pathway":"GO_DENDRITIC_SPINE_MAINTENANCE","pval":0.1562,"padj":0.75836,"ES":-0.94873,"NES":-1.26812,"nMoreExtreme":6180,"size":17,"leadingEdge":["INSR","ITPKA"]} {"pathway":"GO_CORONARY_ARTERY_MORPHOGENESIS","pval":0.28664,"padj":0.84886,"ES":-0.94698,"NES":-1.26849,"nMoreExtreme":12645,"size":9,"leadingEdge":["NRP1"]} {"pathway":"GO_SPERMATID_NUCLEUS_DIFFERENTIATION","pval":0.13911,"padj":0.73468,"ES":-0.96471,"NES":-1.26859,"nMoreExtreme":5886,"size":12,"leadingEdge":["HMGB2"]} {"pathway":"GO_EMBRYONIC_FORELIMB_MORPHOGENESIS","pval":0.22693,"padj":0.81329,"ES":-0.89165,"NES":-1.26954,"nMoreExtreme":8236,"size":25,"leadingEdge":["IFT122","RUNX2"]} {"pathway":"GO_REGULATION_OF_SYNAPSE_MATURATION","pval":0.1523,"padj":0.75292,"ES":-0.96454,"NES":-1.26965,"nMoreExtreme":6533,"size":11,"leadingEdge":["CDC20"]} {"pathway":"GO_DNA_TOPOLOGICAL_CHANGE","pval":0.15083,"padj":0.75221,"ES":-0.96477,"NES":-1.26995,"nMoreExtreme":6470,"size":11,"leadingEdge":["TOP2A","HMGB2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TELOMERE_CAPPING","pval":0.13275,"padj":0.72971,"ES":-0.95598,"NES":-1.26997,"nMoreExtreme":5322,"size":16,"leadingEdge":["PKIB","AURKB","NEK2"]} {"pathway":"GO_CHONDROITIN_SULFATE_CATABOLIC_PROCESS","pval":0.14983,"padj":0.75097,"ES":-0.96499,"NES":-1.27024,"nMoreExtreme":6427,"size":11,"leadingEdge":["VCAN"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INCLUSION_BODY_ASSEMBLY","pval":0.19784,"padj":0.79183,"ES":-0.95836,"NES":-1.2706,"nMoreExtreme":8616,"size":10,"leadingEdge":["SORL1"]} {"pathway":"GO_REGULATION_OF_NON_CANONICAL_WNT_SIGNALING_PATHWAY","pval":0.21023,"padj":0.79831,"ES":-0.9308,"NES":-1.27063,"nMoreExtreme":8027,"size":20,"leadingEdge":["DAB2","TIAM1"]} {"pathway":"GO_TRACHEA_MORPHOGENESIS","pval":0.38214,"padj":0.89036,"ES":-0.93522,"NES":-1.27066,"nMoreExtreme":17158,"size":8,"leadingEdge":["BMP4"]} {"pathway":"GO_RESPONSE_TO_VITAMIN_E","pval":0.27297,"padj":0.83739,"ES":-0.94881,"NES":-1.27094,"nMoreExtreme":12042,"size":9,"leadingEdge":["CAT"]} {"pathway":"GO_PRIMARY_ALCOHOL_CATABOLIC_PROCESS","pval":0.38018,"padj":0.89036,"ES":-0.9355,"NES":-1.27104,"nMoreExtreme":17070,"size":8,"leadingEdge":["SULT1E1","ALDH2"]} {"pathway":"GO_PURINE_CONTAINING_COMPOUND_SALVAGE","pval":0.11327,"padj":0.69895,"ES":-0.96557,"NES":-1.2715,"nMoreExtreme":4659,"size":14,"leadingEdge":["PRTFDC1"]} {"pathway":"GO_VITAMIN_TRANSMEMBRANE_TRANSPORT","pval":0.12744,"padj":0.72213,"ES":-0.96701,"NES":-1.27162,"nMoreExtreme":5392,"size":12,"leadingEdge":["SLC46A1"]} {"pathway":"GO_PURINE_NUCLEOBASE_BIOSYNTHETIC_PROCESS","pval":0.1427,"padj":0.74188,"ES":-0.96628,"NES":-1.27195,"nMoreExtreme":6121,"size":11,"leadingEdge":["SHMT1"]} {"pathway":"GO_PEROXISOME_PROLIFERATOR_ACTIVATED_RECEPTOR_SIGNALING_PATHWAY","pval":0.14215,"padj":0.73965,"ES":-0.95166,"NES":-1.27203,"nMoreExtreme":5624,"size":17,"leadingEdge":["ALOX15"]} {"pathway":"GO_MEIOTIC_SPINDLE_ORGANIZATION","pval":0.14181,"padj":0.73885,"ES":-0.96645,"NES":-1.27217,"nMoreExtreme":6083,"size":11,"leadingEdge":["ESPL1","ASPM","FBXO5"]} {"pathway":"GO_DICHOTOMOUS_SUBDIVISION_OF_AN_EPITHELIAL_TERMINAL_UNIT","pval":0.18907,"padj":0.78592,"ES":-0.95977,"NES":-1.27246,"nMoreExtreme":8234,"size":10,"leadingEdge":["NRP1","CELSR1"]} {"pathway":"GO_ATRIOVENTRICULAR_VALVE_DEVELOPMENT","pval":0.23098,"padj":0.81508,"ES":-0.92415,"NES":-1.2726,"nMoreExtreme":8722,"size":21,"leadingEdge":["HEY1","GJA5","BMP2"]} {"pathway":"GO_PRESYNAPTIC_MEMBRANE_ASSEMBLY","pval":0.49365,"padj":0.91907,"ES":-0.92067,"NES":-1.27304,"nMoreExtreme":22532,"size":7,"leadingEdge":["NLGN2"]} {"pathway":"GO_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_INTERCONVERSION","pval":0.19799,"padj":0.79183,"ES":-0.86508,"NES":-1.27317,"nMoreExtreme":6950,"size":29,"leadingEdge":["AK1","RRM2","TYMS","RRM1","AK7","DUT"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NEUROTROPHIN_TRK_RECEPTOR_SIGNALING_PATHWAY","pval":0.49139,"padj":0.91835,"ES":-0.92095,"NES":-1.27342,"nMoreExtreme":22429,"size":7,"leadingEdge":["NTF3"]} {"pathway":"GO_DESMOSOME_ORGANIZATION","pval":0.18346,"padj":0.77986,"ES":-0.96067,"NES":-1.27366,"nMoreExtreme":7990,"size":10,"leadingEdge":["PRKCA","NECTIN1"]} {"pathway":"GO_CHEMICAL_HOMEOSTASIS_WITHIN_A_TISSUE","pval":0.36375,"padj":0.89036,"ES":-0.93758,"NES":-1.27387,"nMoreExtreme":16332,"size":8,"leadingEdge":["EPAS1","RCN3"]} {"pathway":"GO_ACTIVATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_ACTIVITY","pval":0.13447,"padj":0.72971,"ES":-0.96791,"NES":-1.27409,"nMoreExtreme":5768,"size":11,"leadingEdge":["PDGFC","PRLR"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CENTROSOME_CYCLE","pval":0.13431,"padj":0.72971,"ES":-0.96797,"NES":-1.27417,"nMoreExtreme":5761,"size":11,"leadingEdge":["PLK4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR_VIA_HOMOLOGOUS_RECOMBINATION","pval":0.18108,"padj":0.77555,"ES":-0.96106,"NES":-1.27418,"nMoreExtreme":7886,"size":10,"leadingEdge":["FANCB","BLM"]} {"pathway":"GO_ERROR_FREE_TRANSLESION_SYNTHESIS","pval":0.17069,"padj":0.77295,"ES":-0.94057,"NES":-1.2743,"nMoreExtreme":6585,"size":19,"leadingEdge":["RFC3","RFC5","RFC4","PCNA"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SYNAPSE_ASSEMBLY","pval":0.13726,"padj":0.73301,"ES":-0.77659,"NES":-1.27432,"nMoreExtreme":4145,"size":47,"leadingEdge":["EPHB3","GHRL","THBS2","SYNDIG1","SRPX2","FLRT3","LRRN1","CUX2","LRRTM1","LRRC4B","IL1RAP","NLGN2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CIRCADIAN_RHYTHM","pval":0.13333,"padj":0.72971,"ES":-0.96814,"NES":-1.27439,"nMoreExtreme":5719,"size":11,"leadingEdge":["GHRL","SUV39H2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_DENDRITIC_SPINE_MORPHOGENESIS","pval":0.14785,"padj":0.7508,"ES":-0.94777,"NES":-1.27466,"nMoreExtreme":5789,"size":18,"leadingEdge":["TIAM1","ITPKA","CUX2"]} {"pathway":"GO_ACROSOME_ASSEMBLY","pval":0.25328,"padj":0.82744,"ES":-0.95168,"NES":-1.27478,"nMoreExtreme":11173,"size":9,"leadingEdge":["KNL1","CCDC136"]} {"pathway":"GO_PEPTIDYL_LYSINE_DIMETHYLATION","pval":0.1024,"padj":0.67367,"ES":-0.96808,"NES":-1.2748,"nMoreExtreme":4212,"size":14,"leadingEdge":["SUV39H2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CYTOPLASMIC_TRANSLATION","pval":0.35638,"padj":0.88877,"ES":-0.93853,"NES":-1.27516,"nMoreExtreme":16001,"size":8,"leadingEdge":["RBM24"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MITOTIC_SISTER_CHROMATID_SEGREGATION","pval":0.11392,"padj":0.69895,"ES":-0.95998,"NES":-1.27529,"nMoreExtreme":4567,"size":16,"leadingEdge":["CDT1","ESPL1","DLGAP5","SLF1"]} {"pathway":"GO_MEMBRANE_DISASSEMBLY","pval":0.11392,"padj":0.69895,"ES":-0.95999,"NES":-1.2753,"nMoreExtreme":4567,"size":16,"leadingEdge":["CDK1","PRKCA","CCNB2","PLK1"]} {"pathway":"GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_RECEPTOR_CATABOLIC_PROCESS","pval":0.11078,"padj":0.69745,"ES":-0.97044,"NES":-1.27612,"nMoreExtreme":4687,"size":12,"leadingEdge":["AP2A2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION","pval":0.09745,"padj":0.66591,"ES":-0.9692,"NES":-1.27628,"nMoreExtreme":4008,"size":14,"leadingEdge":["TP73","OLIG2"]} {"pathway":"GO_PRESYNAPTIC_MODULATION_OF_CHEMICAL_SYNAPTIC_TRANSMISSION","pval":0.17164,"padj":0.77295,"ES":-0.96274,"NES":-1.27641,"nMoreExtreme":7475,"size":10,"leadingEdge":["SYT1","PLEKHG5","CACNA1D"]} {"pathway":"GO_EMBRYONIC_HINDLIMB_MORPHOGENESIS","pval":0.18509,"padj":0.77988,"ES":-0.93517,"NES":-1.2766,"nMoreExtreme":7067,"size":20,"leadingEdge":["BMP4"]} {"pathway":"GO_DEOXYRIBONUCLEOSIDE_TRIPHOSPHATE_CATABOLIC_PROCESS","pval":0.34751,"padj":0.88271,"ES":-0.93971,"NES":-1.27677,"nMoreExtreme":15603,"size":8,"leadingEdge":["NUDT1","DUT"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_AMINO_ACID_TRANSPORT","pval":0.47294,"padj":0.90882,"ES":-0.92348,"NES":-1.27692,"nMoreExtreme":21587,"size":7,"leadingEdge":["RGS4"]} {"pathway":"GO_GLYCINE_TRANSPORT","pval":0.47248,"padj":0.90882,"ES":-0.92354,"NES":-1.277,"nMoreExtreme":21566,"size":7,"leadingEdge":["SLC36A1","RGS4"]} {"pathway":"GO_CYTOSKELETAL_ANCHORING_AT_NUCLEAR_MEMBRANE","pval":0.4708,"padj":0.90807,"ES":-0.92376,"NES":-1.27731,"nMoreExtreme":21489,"size":7,"leadingEdge":["SYNE1","SYNE3"]} {"pathway":"GO_CELL_CYCLE_G1_S_PHASE_TRANSITION","pval":0.01818,"padj":0.35354,"ES":-0.60603,"NES":-1.27765,"nMoreExtreme":192,"size":239,"leadingEdge":["CCNE2","IQGAP3","E2F8","E2F1","MCM10","RRM2","CDKN2C","TYMS","CDC45","CDC25A","CDC6","MCM6","MCM7","MCM4","CDT1","MCM2","CDK1","DHFR","CCNA2","ORC1","POLE2","GTSE1","MCM5","WEE1","CDC25C","KANK2","MCM8","KIF14","ORC6","E2F7","JADE1","CTDSPL","POLA1","FBXO5","BCL2","POLE","CDKN2B","MCM3","FAM83D","CDKN3","CCNE1","PCNA","RCC1"]} {"pathway":"GO_RESPONSE_TO_L_GLUTAMATE","pval":0.34255,"padj":0.87929,"ES":-0.94044,"NES":-1.27776,"nMoreExtreme":15380,"size":8,"leadingEdge":["PCNA"]} {"pathway":"GO_MINERALOCORTICOID_BIOSYNTHETIC_PROCESS","pval":0.46823,"padj":0.90738,"ES":-0.92415,"NES":-1.27785,"nMoreExtreme":21372,"size":7,"leadingEdge":["BMP6","BMP2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NUCLEASE_ACTIVITY","pval":0.34159,"padj":0.87818,"ES":-0.94056,"NES":-1.27791,"nMoreExtreme":15337,"size":8,"leadingEdge":["HMGB2","DDX11","PCNA"]} {"pathway":"GO_TELENCEPHALON_REGIONALIZATION","pval":0.46775,"padj":0.90738,"ES":-0.92421,"NES":-1.27793,"nMoreExtreme":21350,"size":7,"leadingEdge":["ADGRG1","BMP4","BMP2"]} {"pathway":"GO_ASYMMETRIC_CELL_DIVISION","pval":0.09195,"padj":0.66374,"ES":-0.97049,"NES":-1.27799,"nMoreExtreme":3782,"size":14,"leadingEdge":["ASPM"]} {"pathway":"GO_TRIGLYCERIDE_CATABOLIC_PROCESS","pval":0.15548,"padj":0.75836,"ES":-0.94341,"NES":-1.27815,"nMoreExtreme":5998,"size":19,"leadingEdge":["LPL","PNPLA3"]} {"pathway":"GO_REGULATION_OF_CIRCADIAN_SLEEP_WAKE_CYCLE","pval":0.46482,"padj":0.90571,"ES":-0.92456,"NES":-1.27841,"nMoreExtreme":21216,"size":7,"leadingEdge":["GHRL"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_RNA_CATABOLIC_PROCESS","pval":0.12909,"padj":0.72213,"ES":-0.76842,"NES":-1.27853,"nMoreExtreme":3828,"size":50,"leadingEdge":["SLC11A1","E2F1","DAZL"]} {"pathway":"GO_DETECTION_OF_LIGHT_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION","pval":0.46313,"padj":0.90517,"ES":-0.92477,"NES":-1.27871,"nMoreExtreme":21139,"size":7,"leadingEdge":["CACNA2D4"]} {"pathway":"GO_LIPOPROTEIN_LOCALIZATION","pval":0.08894,"padj":0.6584,"ES":-0.97128,"NES":-1.27902,"nMoreExtreme":3658,"size":14,"leadingEdge":["UNC119B"]} {"pathway":"GO_REGULATION_OF_MITOTIC_CENTROSOME_SEPARATION","pval":0.22868,"padj":0.81508,"ES":-0.95522,"NES":-1.27952,"nMoreExtreme":10088,"size":9,"leadingEdge":["KIF11","CHEK1","NEK2","KIF25"]} {"pathway":"GO_MAMMARY_GLAND_ALVEOLUS_DEVELOPMENT","pval":0.09103,"padj":0.66096,"ES":-0.96833,"NES":-1.27957,"nMoreExtreme":3693,"size":15,"leadingEdge":["TNFRSF11A","TNFSF11"]} {"pathway":"GO_REGULATION_OF_GLYCOGEN_METABOLIC_PROCESS","pval":0.1993,"padj":0.79183,"ES":-0.87589,"NES":-1.2797,"nMoreExtreme":7055,"size":28,"leadingEdge":["INSR","KHK","PASK","IRS2","PPP1R3G"]} {"pathway":"GO_NEURAL_PLATE_PATTERN_SPECIFICATION","pval":0.33072,"padj":0.87332,"ES":-0.94202,"NES":-1.2799,"nMoreExtreme":14849,"size":8,"leadingEdge":["SSBP3","CELSR2"]} {"pathway":"GO_COMMISSURAL_NEURON_AXON_GUIDANCE","pval":0.09757,"padj":0.66591,"ES":-0.97347,"NES":-1.28012,"nMoreExtreme":4128,"size":12,"leadingEdge":["NRP1","FZD3"]} {"pathway":"GO_MAINTENANCE_OF_CELL_POLARITY","pval":0.09798,"padj":0.66591,"ES":-0.96386,"NES":-1.28044,"nMoreExtreme":3928,"size":16,"leadingEdge":["ANK1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_LIPOPOLYSACCHARIDE_MEDIATED_SIGNALING_PATHWAY","pval":0.32707,"padj":0.87108,"ES":-0.94252,"NES":-1.28058,"nMoreExtreme":14685,"size":8,"leadingEdge":["PRKCA","CD180","BMP6"]} {"pathway":"GO_MULTICELLULAR_ORGANISMAL_IRON_ION_HOMEOSTASIS","pval":0.32707,"padj":0.87108,"ES":-0.94252,"NES":-1.28058,"nMoreExtreme":14685,"size":8,"leadingEdge":["SLC11A1","SLC40A1","BMP6"]} {"pathway":"GO_MITOCHONDRIAL_DNA_REPLICATION","pval":0.09544,"padj":0.66591,"ES":-0.97398,"NES":-1.28078,"nMoreExtreme":4038,"size":12,"leadingEdge":["DNA2"]} {"pathway":"GO_OLIGOPEPTIDE_TRANSPORT","pval":0.32339,"padj":0.86974,"ES":-0.94297,"NES":-1.2812,"nMoreExtreme":14520,"size":8,"leadingEdge":["SLC9A3R1"]} {"pathway":"GO_ESTABLISHMENT_OF_GOLGI_LOCALIZATION","pval":0.32339,"padj":0.86974,"ES":-0.94297,"NES":-1.2812,"nMoreExtreme":14520,"size":8,"leadingEdge":["SLC9A3R1"]} {"pathway":"GO_DNA_ENDOREDUPLICATION","pval":0.14962,"padj":0.75097,"ES":-0.96645,"NES":-1.28133,"nMoreExtreme":6516,"size":10,"leadingEdge":["E2F8","E2F7","FBXO5"]} {"pathway":"GO_ESTABLISHMENT_OF_SISTER_CHROMATID_COHESION","pval":0.32208,"padj":0.86926,"ES":-0.94314,"NES":-1.28142,"nMoreExtreme":14461,"size":8,"leadingEdge":["CDCA5","DDX11"]} {"pathway":"GO_REGULATION_OF_MITOCHONDRIAL_FUSION","pval":0.21397,"padj":0.7999,"ES":-0.95741,"NES":-1.28246,"nMoreExtreme":9439,"size":9,"leadingEdge":["PID1"]} {"pathway":"GO_SOMATIC_STEM_CELL_DIVISION","pval":0.13998,"padj":0.73663,"ES":-0.94665,"NES":-1.28253,"nMoreExtreme":5400,"size":19,"leadingEdge":["LBH","ASPM","FZD7","FGFR1"]} {"pathway":"GO_MODIFICATION_OF_POSTSYNAPTIC_ACTIN_CYTOSKELETON","pval":0.21363,"padj":0.7999,"ES":-0.95746,"NES":-1.28253,"nMoreExtreme":9424,"size":9,"leadingEdge":["CTTNBP2","TIAM1"]} {"pathway":"GO_REGULATION_OF_MODIFICATION_OF_SYNAPTIC_STRUCTURE","pval":0.21363,"padj":0.7999,"ES":-0.95746,"NES":-1.28253,"nMoreExtreme":9424,"size":9,"leadingEdge":["CTTNBP2","TIAM1"]} {"pathway":"GO_DEOXYRIBOSE_PHOSPHATE_CATABOLIC_PROCESS","pval":0.16003,"padj":0.76421,"ES":-0.93973,"NES":-1.28282,"nMoreExtreme":6110,"size":20,"leadingEdge":["UNG","NUDT1","DUT"]} {"pathway":"GO_POSITIVE_REGULATION_OF_RYANODINE_SENSITIVE_CALCIUM_RELEASE_CHANNEL_ACTIVITY","pval":0.31399,"padj":0.86489,"ES":-0.94426,"NES":-1.28295,"nMoreExtreme":14098,"size":8,"leadingEdge":["TRDN","AKAP6","GSTM2"]} {"pathway":"GO_GLUCOSE_METABOLIC_PROCESS","pval":0.0714,"padj":0.62112,"ES":-0.68393,"NES":-1.28308,"nMoreExtreme":1576,"size":95,"leadingEdge":["PDK4","GHRL","SLC45A3","NISCH","INSR","KHK","PASK","IGFBP3","IRS2","PPP1R3G","PRKN"]} {"pathway":"GO_CEREBELLAR_PURKINJE_CELL_LAYER_MORPHOGENESIS","pval":0.09885,"padj":0.66699,"ES":-0.97505,"NES":-1.28349,"nMoreExtreme":4240,"size":11,"leadingEdge":["DLL1","KIF14"]} {"pathway":"GO_SEMINIFEROUS_TUBULE_DEVELOPMENT","pval":0.09813,"padj":0.66591,"ES":-0.97522,"NES":-1.28371,"nMoreExtreme":4209,"size":11,"leadingEdge":["ADGRG1"]} {"pathway":"GO_DNA_UNWINDING_INVOLVED_IN_DNA_REPLICATION","pval":0.09778,"padj":0.66591,"ES":-0.97527,"NES":-1.28378,"nMoreExtreme":4194,"size":11,"leadingEdge":["MCM6","MCM7","MCM4","MCM2","RAD51"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CHROMOSOME_SEPARATION","pval":0.13961,"padj":0.73582,"ES":-0.96831,"NES":-1.28379,"nMoreExtreme":6080,"size":10,"leadingEdge":["CDT1","ESPL1","DLGAP5"]} {"pathway":"GO_ERROR_PRONE_TRANSLESION_SYNTHESIS","pval":0.1561,"padj":0.75836,"ES":-0.94063,"NES":-1.28404,"nMoreExtreme":5960,"size":20,"leadingEdge":["POLE2","RFC3","RFC5","RFC4","PCNA"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CENTRIOLE_REPLICATION","pval":0.30803,"padj":0.86308,"ES":-0.94511,"NES":-1.2841,"nMoreExtreme":13830,"size":8,"leadingEdge":["BRCA1","KAT2A"]} {"pathway":"GO_REGULATION_OF_POSTSYNAPTIC_CYTOSOLIC_CALCIUM_ION_CONCENTRATION","pval":0.43097,"padj":0.89981,"ES":-0.92898,"NES":-1.28453,"nMoreExtreme":19671,"size":7,"leadingEdge":["FZD9","MYO5A"]} {"pathway":"GO_STABILIZATION_OF_MEMBRANE_POTENTIAL","pval":0.42696,"padj":0.8986,"ES":-0.92949,"NES":-1.28523,"nMoreExtreme":19488,"size":7,"leadingEdge":["KCNK5"]} {"pathway":"GO_G2_DNA_DAMAGE_CHECKPOINT","pval":0.17882,"padj":0.77529,"ES":-0.86008,"NES":-1.28528,"nMoreExtreme":6175,"size":31,"leadingEdge":["CLSPN","CDK1","BRCA1","DTL","CHEK1","BLM","PLK1","DONSON"]} {"pathway":"GO_INNER_EAR_RECEPTOR_CELL_DEVELOPMENT","pval":0.17871,"padj":0.77529,"ES":-0.86019,"NES":-1.28544,"nMoreExtreme":6171,"size":31,"leadingEdge":["SLC4A7","MYO7A","FGFR1","SLC9A3R1"]} {"pathway":"GO_HINDBRAIN_RADIAL_GLIA_GUIDED_CELL_MIGRATION","pval":0.29956,"padj":0.85717,"ES":-0.94627,"NES":-1.28567,"nMoreExtreme":13450,"size":8,"leadingEdge":["DAB1"]} {"pathway":"GO_CATECHOLAMINE_UPTAKE_INVOLVED_IN_SYNAPTIC_TRANSMISSION","pval":0.42308,"padj":0.89612,"ES":-0.93,"NES":-1.28593,"nMoreExtreme":19311,"size":7,"leadingEdge":["PRKN"]} {"pathway":"GO_SPONTANEOUS_SYNAPTIC_TRANSMISSION","pval":0.42308,"padj":0.89612,"ES":-0.93,"NES":-1.28593,"nMoreExtreme":19311,"size":7,"leadingEdge":["PRKN"]} {"pathway":"GO_MEMBRANE_HYPERPOLARIZATION","pval":0.42258,"padj":0.89612,"ES":-0.93005,"NES":-1.28601,"nMoreExtreme":19288,"size":7,"leadingEdge":["KCNQ3"]} {"pathway":"GO_G_PROTEIN_COUPLED_RECEPTOR_INTERNALIZATION","pval":0.09018,"padj":0.66071,"ES":-0.97702,"NES":-1.28608,"nMoreExtreme":3868,"size":11,"leadingEdge":["NECAB2","DNM1","HTR2B"]} {"pathway":"GO_TELOMERIC_D_LOOP_DISASSEMBLY","pval":0.19155,"padj":0.79001,"ES":-0.96106,"NES":-1.28735,"nMoreExtreme":8450,"size":9,"leadingEdge":["RECQL4","BLM"]} {"pathway":"GO_DNA_STRAND_RENATURATION","pval":0.1911,"padj":0.79001,"ES":-0.96112,"NES":-1.28742,"nMoreExtreme":8430,"size":9,"leadingEdge":["RAD54L","RECQL4","BLM"]} {"pathway":"GO_DNA_REPLICATION_CHECKPOINT","pval":0.0691,"padj":0.61412,"ES":-0.97431,"NES":-1.28747,"nMoreExtreme":2803,"size":15,"leadingEdge":["CDC45","CDC6","CLSPN","TICRR","CDT1","ORC1","DNA2"]} {"pathway":"GO_QUINONE_METABOLIC_PROCESS","pval":0.41467,"padj":0.89503,"ES":-0.93112,"NES":-1.28749,"nMoreExtreme":18927,"size":7,"leadingEdge":["AKR7A2"]} {"pathway":"GO_CLATHRIN_DEPENDENT_ENDOCYTOSIS","pval":0.14608,"padj":0.74879,"ES":-0.81811,"NES":-1.28781,"nMoreExtreme":4685,"size":39,"leadingEdge":["DAB2","DNM1","DLL1","AP2A2","HIP1","FNBP1L"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT","pval":0.16939,"padj":0.77295,"ES":-0.93523,"NES":-1.28785,"nMoreExtreme":6396,"size":21,"leadingEdge":["RFLNB","BMP4"]} {"pathway":"GO_REGULATION_OF_SKELETAL_MUSCLE_FIBER_DEVELOPMENT","pval":0.50422,"padj":0.91988,"ES":-0.88377,"NES":-1.28795,"nMoreExtreme":23742,"size":5,"leadingEdge":["BCL2"]} {"pathway":"GO_SEX_DETERMINATION","pval":0.06602,"padj":0.60375,"ES":-0.97516,"NES":-1.28859,"nMoreExtreme":2678,"size":15,"leadingEdge":["INSR"]} {"pathway":"GO_RESPONSE_TO_PLATELET_AGGREGATION_INHIBITOR","pval":0.11952,"padj":0.70363,"ES":-0.97213,"NES":-1.28886,"nMoreExtreme":5205,"size":10,"leadingEdge":["ADCY1"]} {"pathway":"GO_MITOTIC_G2_M_TRANSITION_CHECKPOINT","pval":0.1856,"padj":0.77993,"ES":-0.87583,"NES":-1.28899,"nMoreExtreme":6515,"size":29,"leadingEdge":["CDC6","CLSPN","TICRR","CDK1","BRCA1","ORC1","BLM"]} {"pathway":"GO_MODULATION_OF_MOLECULAR_FUNCTION_IN_OTHER_ORGANISM","pval":0.40613,"padj":0.89503,"ES":-0.9323,"NES":-1.28912,"nMoreExtreme":18537,"size":7,"leadingEdge":["PTX3"]} {"pathway":"GO_REGULATION_OF_CENTRIOLE_REPLICATION","pval":0.16399,"padj":0.76986,"ES":-0.93624,"NES":-1.28925,"nMoreExtreme":6192,"size":21,"leadingEdge":["BRCA1","PLK4","KAT2A","STIL"]} {"pathway":"GO_EPITHELIAL_CELL_CELL_ADHESION","pval":0.07778,"padj":0.63581,"ES":-0.97971,"NES":-1.28963,"nMoreExtreme":3336,"size":11,"leadingEdge":["ITGB5"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_HYDROPEROXIDE","pval":0.27237,"padj":0.83739,"ES":-0.94988,"NES":-1.29059,"nMoreExtreme":12229,"size":8,"leadingEdge":["TP53INP1"]} {"pathway":"GO_AUTOPHAGIC_CELL_DEATH","pval":0.27201,"padj":0.83739,"ES":-0.94994,"NES":-1.29066,"nMoreExtreme":12213,"size":8,"leadingEdge":["TREM2","TP53INP1"]} {"pathway":"GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_LIPID_ANTIGEN_VIA_MHC_CLASS_IB","pval":0.39727,"padj":0.89503,"ES":-0.93342,"NES":-1.29067,"nMoreExtreme":18133,"size":7,"leadingEdge":["CD1A","CD1C","CD1B","CD1E"]} {"pathway":"GO_MITOTIC_SPINDLE_ASSEMBLY","pval":0.11826,"padj":0.70259,"ES":-0.77012,"NES":-1.29076,"nMoreExtreme":3453,"size":52,"leadingEdge":["MYBL2","BIRC5","KIF11","AURKB","KIFC1","NEK2","TPX2","KIF4A","CDC20","PLK1","RACGAP1"]} {"pathway":"GO_ADAPTATION_OF_SIGNALING_PATHWAY","pval":0.05951,"padj":0.58367,"ES":-0.97701,"NES":-1.29104,"nMoreExtreme":2414,"size":15,"leadingEdge":["NECAB2","DNM1","HTR2B"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_NITROGEN_STARVATION","pval":0.07228,"padj":0.62163,"ES":-0.98084,"NES":-1.29111,"nMoreExtreme":3100,"size":11,"leadingEdge":["MAP1LC3C"]} {"pathway":"GO_MAINTENANCE_OF_APICAL_BASAL_CELL_POLARITY","pval":0.17437,"padj":0.77529,"ES":-0.96387,"NES":-1.29111,"nMoreExtreme":7692,"size":9,"leadingEdge":["ANK1"]} {"pathway":"GO_MITOCHONDRIAL_DNA_METABOLIC_PROCESS","pval":0.11046,"padj":0.69745,"ES":-0.97398,"NES":-1.29131,"nMoreExtreme":4810,"size":10,"leadingEdge":["DNA2"]} {"pathway":"GO_CALCINEURIN_MEDIATED_SIGNALING","pval":0.13669,"padj":0.73299,"ES":-0.80672,"NES":-1.29143,"nMoreExtreme":4295,"size":42,"leadingEdge":["MYOZ2","AKAP6","HOMER3"]} {"pathway":"GO_STRIATED_MUSCLE_MYOSIN_THICK_FILAMENT_ASSEMBLY","pval":0.38551,"padj":0.89163,"ES":-0.93494,"NES":-1.29277,"nMoreExtreme":17596,"size":7,"leadingEdge":["MYOM1","MYOM3"]} {"pathway":"GO_REGULATION_OF_GLYCOGEN_STARCH_SYNTHASE_ACTIVITY","pval":0.38551,"padj":0.89163,"ES":-0.93494,"NES":-1.29277,"nMoreExtreme":17596,"size":7,"leadingEdge":["PPP1R3G"]} {"pathway":"GO_DEFINITIVE_HEMOPOIESIS","pval":0.09096,"padj":0.66096,"ES":-0.96132,"NES":-1.29288,"nMoreExtreme":3561,"size":18,"leadingEdge":["TAL1","TGFBR3"]} {"pathway":"GO_REGULATION_OF_VASCULAR_SMOOTH_MUSCLE_CONTRACTION","pval":0.38435,"padj":0.89083,"ES":-0.93511,"NES":-1.293,"nMoreExtreme":17543,"size":7,"leadingEdge":["ADRA2B","CHRM3"]} {"pathway":"GO_PROSTANOID_METABOLIC_PROCESS","pval":0.10302,"padj":0.6741,"ES":-0.97533,"NES":-1.2931,"nMoreExtreme":4486,"size":10,"leadingEdge":["HPGD"]} {"pathway":"GO_EMBRYONIC_SKELETAL_JOINT_MORPHOGENESIS","pval":0.38352,"padj":0.89036,"ES":-0.93522,"NES":-1.29316,"nMoreExtreme":17505,"size":7,"leadingEdge":["BMP4"]} {"pathway":"GO_CARDIAC_NEURAL_CREST_CELL_DEVELOPMENT_INVOLVED_IN_OUTFLOW_TRACT_MORPHOGENESIS","pval":0.38352,"padj":0.89036,"ES":-0.93522,"NES":-1.29316,"nMoreExtreme":17505,"size":7,"leadingEdge":["BMP4"]} {"pathway":"GO_S_SHAPED_BODY_MORPHOGENESIS","pval":0.38352,"padj":0.89036,"ES":-0.93522,"NES":-1.29316,"nMoreExtreme":17505,"size":7,"leadingEdge":["BMP4"]} {"pathway":"GO_FEAR_RESPONSE","pval":0.19506,"padj":0.79001,"ES":-0.89294,"NES":-1.29321,"nMoreExtreme":6963,"size":27,"leadingEdge":["ASIC1","BCL2","ADRB1","GNG7"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ERAD_PATHWAY","pval":0.04995,"padj":0.55243,"ES":-0.98353,"NES":-1.29322,"nMoreExtreme":2085,"size":13,"leadingEdge":["DERL3"]} {"pathway":"GO_BRONCHUS_DEVELOPMENT","pval":0.38306,"padj":0.89036,"ES":-0.93528,"NES":-1.29323,"nMoreExtreme":17484,"size":7,"leadingEdge":["AGR2","BMP4"]} {"pathway":"GO_HISTONE_METHYLATION","pval":0.05399,"padj":0.56056,"ES":-0.6697,"NES":-1.29327,"nMoreExtreme":1059,"size":115,"leadingEdge":["BRCA1","SUV39H2","SMYD3","MYB","LMNA","JARID2","SETD6","KMT5C"]} {"pathway":"GO_LIPID_DROPLET_ORGANIZATION","pval":0.05242,"padj":0.55686,"ES":-0.97909,"NES":-1.29378,"nMoreExtreme":2126,"size":15,"leadingEdge":["PNPLA3","PTGFRN"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_CELL_CORTEX","pval":0.10058,"padj":0.67187,"ES":-0.9759,"NES":-1.29386,"nMoreExtreme":4380,"size":10,"leadingEdge":["ANLN"]} {"pathway":"GO_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION","pval":0.06325,"padj":0.59455,"ES":-0.68527,"NES":-1.29386,"nMoreExtreme":1362,"size":99,"leadingEdge":["KIF18B","STMN1","SKA3","SKA1","KIF2C","FBXO5","KIF24","CDK5R1"]} {"pathway":"GO_CELL_CYCLE","pval":0.025,"padj":0.40148,"ES":-0.55214,"NES":-1.2941,"nMoreExtreme":0,"size":1589,"leadingEdge":["CCNE2","IQGAP3","E2F2","E2F8","TOP2A","MEIKIN","E2F1","CD28","MYBL2","MCM10","SPC25","RRM2","CDKN2C","TYMS","CDC45","TAL1","CDC25A","CDC6","RAD54L","PCLAF","CLSPN","TICRR","MCM6","RECQL4","CDCA3","MCM7","EXO1","DSCC1","HELLS","MCM4","ESCO2","DMC1","KIF18B","CDT1","ERCC6L","LRP5","MCM2","KIF15","SPC24","FEN1","NCAPG","CDCA5","ZWINT","PKMYT1","OIP5","CDK1","BIRC5","XRCC2","ANLN","DHFR","BRCA1","DTL","PRC1","MKI67","CCNA2","WDR76","KIF11","MAD2L1","ORC1","CHAF1B","NCAPG2","TACC2","NUF2","POLE2","NUSAP1","UHRF1","GTSE1","NDC80","AURKB","MCM5","NCAPH","STMN1","CCNF","APPL2","BUB1B","CENPF","HJURP","WDR62","EME1","CHTF18","WEE1","GINS1","SKA3","MYBL1","KIFC1","HASPIN","PDE3A","MND1","CDC25C","KANK2","PRKCA","RFC3","TTK","TP73","MCM8","ESPL1","SPAG5","SKA1","CIT","RFC5","AUNIP","HPGD","RFC4","INSR","RAD51","KIF14","PIMREG","DNA2","ORC6","FZD3","MAP2K6","E2F7","CDK15","JADE1","FOXM1","WDHD1","KIF2C","CHAF1A","ASPM","FANCI","KNL1","UBE2C","CTDSPL","POLA1","CENPA","DLGAP5","SUV39H2","PLK4","SGO1","CCNB2","MAPK13","CHEK1","NEK2","PSMC3IP","TPX2","KIF4A","FBXO5","CDCA8","BCL2","BUB1","CDC20","NCAPD3","POLE","MNS1","PBK","RRM1","TRIP13","KIF20A","FZD9","FBXO43","BLM","CDCA2","PLK1","SLF1","NEK10","SMC4","MYB","CEP55","CDK5R1","GPR3","CDKN2B","DHCR24","KIF25","SMC2","CENPS","MCM3","LMNA","PRKACB","CABLES1","XRCC3","TP53INP1","FAM83D","TACC3","DSN1","RTTN","FGFR1","NCAPD2","CENPE","CDKN3","KAT2A","CCNE1","THBS1","NES","DDX11","SLC9A3R1","CAMK1","LIN9","HMMR","CEP72","PCNA","RCC1","RACGAP1","USP51","DONSON","CENPQ","USP2","ZNF503","DDIAS","TPD52L1","STIL","NCAPH2","BMP4","ATAD5","CDC7","KIF22","RBL1","ID3"]} {"pathway":"GO_RESPONSE_TO_GLUCAGON","pval":0.20885,"padj":0.79637,"ES":-0.90892,"NES":-1.29413,"nMoreExtreme":7580,"size":25,"leadingEdge":["CCNA2","ADCY1","ADCY4","PRKACB"]} {"pathway":"GO_ESTABLISHMENT_OF_PLANAR_POLARITY_INVOLVED_IN_NEURAL_TUBE_CLOSURE","pval":0.04589,"padj":0.53762,"ES":-0.98325,"NES":-1.29479,"nMoreExtreme":1887,"size":14,"leadingEdge":["CELSR1"]} {"pathway":"GO_BRAINSTEM_DEVELOPMENT","pval":0.52128,"padj":0.9256,"ES":-0.91438,"NES":-1.29482,"nMoreExtreme":24151,"size":6,"leadingEdge":["CNTFR","SCN5A"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY","pval":0.24765,"padj":0.82387,"ES":-0.95353,"NES":-1.29555,"nMoreExtreme":11119,"size":8,"leadingEdge":["FZD9","MPV17L"]} {"pathway":"GO_PROSTATE_GLAND_GROWTH","pval":0.24471,"padj":0.82387,"ES":-0.95393,"NES":-1.29608,"nMoreExtreme":10987,"size":8,"leadingEdge":["CYP19A1"]} {"pathway":"GO_HISTONE_H3_K9_MODIFICATION","pval":0.13548,"padj":0.73185,"ES":-0.81363,"NES":-1.29611,"nMoreExtreme":4288,"size":41,"leadingEdge":["BRCA1","SUV39H2","CHEK1","MYB","LMNA","JARID2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PROTEIN_ACETYLATION","pval":0.11548,"padj":0.70006,"ES":-0.94952,"NES":-1.29619,"nMoreExtreme":4409,"size":20,"leadingEdge":["BRCA1"]} {"pathway":"GO_ESTABLISHMENT_OF_EPITHELIAL_CELL_POLARITY","pval":0.19948,"padj":0.79183,"ES":-0.90329,"NES":-1.29664,"nMoreExtreme":7184,"size":26,"leadingEdge":["FRMD4A","SLC9A3R1"]} {"pathway":"GO_METHYLATION_DEPENDENT_CHROMATIN_SILENCING","pval":0.08125,"padj":0.64456,"ES":-0.96416,"NES":-1.2967,"nMoreExtreme":3181,"size":18,"leadingEdge":["HELLS"]} {"pathway":"GO_RETINA_VASCULATURE_MORPHOGENESIS_IN_CAMERA_TYPE_EYE","pval":0.08986,"padj":0.66033,"ES":-0.97814,"NES":-1.29683,"nMoreExtreme":3913,"size":10,"leadingEdge":["NRP1","LRP5"]} {"pathway":"GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_CORTEX","pval":0.51299,"padj":0.92459,"ES":-0.91584,"NES":-1.29689,"nMoreExtreme":23767,"size":6,"leadingEdge":["SAPCD2"]} {"pathway":"GO_HEART_TRABECULA_MORPHOGENESIS","pval":0.19931,"padj":0.79183,"ES":-0.90352,"NES":-1.29698,"nMoreExtreme":7178,"size":26,"leadingEdge":["S1PR1","TGFBR3","HEY1","RBP4","ENG"]} {"pathway":"GO_PURINE_NUCLEOTIDE_SALVAGE","pval":0.51245,"padj":0.92419,"ES":-0.91596,"NES":-1.29705,"nMoreExtreme":23742,"size":6,"leadingEdge":["AMPD2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MITOTIC_SISTER_CHROMATID_SEPARATION","pval":0.14837,"padj":0.7508,"ES":-0.96831,"NES":-1.29706,"nMoreExtreme":6545,"size":9,"leadingEdge":["CDT1","ESPL1","DLGAP5"]} {"pathway":"GO_KINETOCHORE_ORGANIZATION","pval":0.13669,"padj":0.73299,"ES":-0.94192,"NES":-1.29707,"nMoreExtreme":5161,"size":21,"leadingEdge":["CDT1","NUF2","NDC80","CENPK","CENPF","CENPA","CENPH","SMC4","SMC2","CENPS","CENPE","CENPN"]} {"pathway":"GO_NEURAL_TUBE_DEVELOPMENT","pval":0.04103,"padj":0.51837,"ES":-0.65446,"NES":-1.29718,"nMoreExtreme":706,"size":139,"leadingEdge":["SSBP3","PLXNA2","IFT122","CELSR1","SOX17","INKA1","FZD3","GDF7","PRKACB","IFT172","CC2D2A","SEMA4C","KAT2A","SKI","STIL","BMP4","KIF20B","SHROOM3"]} {"pathway":"GO_MODIFICATION_OF_SYNAPTIC_STRUCTURE","pval":0.09525,"padj":0.66591,"ES":-0.9575,"NES":-1.29723,"nMoreExtreme":3674,"size":19,"leadingEdge":["CTTNBP2","DLGAP3","TIAM1"]} {"pathway":"GO_VERY_LOW_DENSITY_LIPOPROTEIN_PARTICLE_CLEARANCE","pval":0.50978,"padj":0.92379,"ES":-0.91635,"NES":-1.2976,"nMoreExtreme":23618,"size":6,"leadingEdge":["APOC1"]} {"pathway":"GO_REGULATION_OF_PHOSPHOLIPID_CATABOLIC_PROCESS","pval":0.50978,"padj":0.92379,"ES":-0.91635,"NES":-1.2976,"nMoreExtreme":23618,"size":6,"leadingEdge":["APOC1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_I","pval":0.13081,"padj":0.72638,"ES":-0.94304,"NES":-1.29862,"nMoreExtreme":4939,"size":21,"leadingEdge":["DDX11"]} {"pathway":"GO_POSITIVE_REGULATION_OF_HISTONE_H3_K9_METHYLATION","pval":0.35175,"padj":0.88735,"ES":-0.93943,"NES":-1.29898,"nMoreExtreme":16055,"size":7,"leadingEdge":["BRCA1","MYB","LMNA","JARID2"]} {"pathway":"GO_REGULATION_OF_SISTER_CHROMATID_COHESION","pval":0.1297,"padj":0.72293,"ES":-0.94332,"NES":-1.299,"nMoreExtreme":4897,"size":21,"leadingEdge":["FEN1","CDCA5","ESPL1","BUB1","SLF1","DDX11"]} {"pathway":"GO_ESTABLISHMENT_OF_PLANAR_POLARITY_OF_EMBRYONIC_EPITHELIUM","pval":0.04044,"padj":0.51539,"ES":-0.98325,"NES":-1.29928,"nMoreExtreme":1640,"size":15,"leadingEdge":["CELSR1"]} {"pathway":"GO_DIET_INDUCED_THERMOGENESIS","pval":0.34548,"padj":0.88254,"ES":-0.94033,"NES":-1.30023,"nMoreExtreme":15769,"size":7,"leadingEdge":["APPL2","ADRB1","BMP8A"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_HISTONE_ACETYLATION","pval":0.03235,"padj":0.46027,"ES":-0.98752,"NES":-1.30041,"nMoreExtreme":1330,"size":14,"leadingEdge":["BRCA1"]} {"pathway":"GO_REGULATION_OF_UBIQUITIN_PROTEIN_LIGASE_ACTIVITY","pval":0.08641,"padj":0.65271,"ES":-0.95994,"NES":-1.30054,"nMoreExtreme":3333,"size":19,"leadingEdge":["MAD2L1","UBE2C","FBXO5","CDC20","PLK1"]} {"pathway":"GO_BASE_EXCISION_REPAIR_AP_SITE_FORMATION","pval":0.07436,"padj":0.62748,"ES":-0.98146,"NES":-1.30122,"nMoreExtreme":3238,"size":10,"leadingEdge":["UNG"]} {"pathway":"GO_POSITIVE_REGULATION_OF_WNT_SIGNALING_PATHWAY_PLANAR_CELL_POLARITY_PATHWAY","pval":0.22028,"padj":0.80441,"ES":-0.95772,"NES":-1.30123,"nMoreExtreme":9890,"size":8,"leadingEdge":["DAB2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS","pval":0.16517,"padj":0.76992,"ES":-0.93005,"NES":-1.30172,"nMoreExtreme":6124,"size":23,"leadingEdge":["BRCA1","BCL2","PRKN"]} {"pathway":"GO_RESPONSE_TO_FORSKOLIN","pval":0.128,"padj":0.72213,"ES":-0.97213,"NES":-1.30218,"nMoreExtreme":5646,"size":9,"leadingEdge":["ADCY1"]} {"pathway":"GO_MACROPINOCYTOSIS","pval":0.0711,"padj":0.62112,"ES":-0.98219,"NES":-1.30219,"nMoreExtreme":3096,"size":10,"leadingEdge":["APPL2"]} {"pathway":"GO_SEQUESTERING_OF_EXTRACELLULAR_LIGAND_FROM_RECEPTOR","pval":0.33407,"padj":0.87575,"ES":-0.94191,"NES":-1.3024,"nMoreExtreme":15248,"size":7,"leadingEdge":["GREM2"]} {"pathway":"GO_DETERMINATION_OF_DORSAL_VENTRAL_ASYMMETRY","pval":0.33407,"padj":0.87575,"ES":-0.94191,"NES":-1.3024,"nMoreExtreme":15248,"size":7,"leadingEdge":["GREM2"]} {"pathway":"GO_FORELIMB_MORPHOGENESIS","pval":0.18196,"padj":0.7772,"ES":-0.89164,"NES":-1.30271,"nMoreExtreme":6441,"size":28,"leadingEdge":["IFT122","RUNX2"]} {"pathway":"GO_POSTSYNAPTIC_DENSITY_PROTEIN_95_CLUSTERING","pval":0.48148,"padj":0.91676,"ES":-0.92067,"NES":-1.30373,"nMoreExtreme":22307,"size":6,"leadingEdge":["NLGN2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_INHIBITORY_POSTSYNAPTIC_POTENTIAL","pval":0.48111,"padj":0.91676,"ES":-0.92073,"NES":-1.30381,"nMoreExtreme":22290,"size":6,"leadingEdge":["NTSR1","NLGN2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PROTEIN_EXIT_FROM_ENDOPLASMIC_RETICULUM","pval":0.0653,"padj":0.60364,"ES":-0.98354,"NES":-1.30398,"nMoreExtreme":2843,"size":10,"leadingEdge":["DERL3"]} {"pathway":"GO_REGULATION_OF_ENDODEOXYRIBONUCLEASE_ACTIVITY","pval":0.3254,"padj":0.87041,"ES":-0.94309,"NES":-1.30403,"nMoreExtreme":14852,"size":7,"leadingEdge":["DDX11"]} {"pathway":"GO_CAMP_BIOSYNTHETIC_PROCESS","pval":0.20672,"padj":0.79637,"ES":-0.95983,"NES":-1.3041,"nMoreExtreme":9281,"size":8,"leadingEdge":["ADCY1","ADCY4"]} {"pathway":"GO_G_QUADRUPLEX_DNA_UNWINDING","pval":0.32458,"padj":0.86994,"ES":-0.9432,"NES":-1.30419,"nMoreExtreme":14815,"size":7,"leadingEdge":["DNA2","BLM","DDX11"]} {"pathway":"GO_PIRNA_BIOSYNTHETIC_PROCESS","pval":0.04183,"padj":0.51963,"ES":-0.97894,"NES":-1.30432,"nMoreExtreme":2089,"size":1,"leadingEdge":["MYBL1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_HISTONE_MODIFICATION","pval":0.14406,"padj":0.74343,"ES":-0.84322,"NES":-1.30447,"nMoreExtreme":4755,"size":36,"leadingEdge":["BRCA1","SKI","JARID2"]} {"pathway":"GO_REGULATION_OF_STEM_CELL_POPULATION_MAINTENANCE","pval":0.09215,"padj":0.66428,"ES":-0.95574,"NES":-1.30468,"nMoreExtreme":3518,"size":20,"leadingEdge":["LBH","TAL1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY","pval":0.02377,"padj":0.39128,"ES":-0.9923,"NES":-1.30487,"nMoreExtreme":1005,"size":12,"leadingEdge":["DAB2"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_NUCLEAR_ENVELOPE","pval":0.20249,"padj":0.79569,"ES":-0.9605,"NES":-1.30501,"nMoreExtreme":9091,"size":8,"leadingEdge":["PLK1"]} {"pathway":"GO_REGULATION_OF_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY","pval":0.02855,"padj":0.42091,"ES":-0.99163,"NES":-1.30531,"nMoreExtreme":1224,"size":11,"leadingEdge":["DHRS3"]} {"pathway":"GO_DOUBLE_STRAND_BREAK_REPAIR_VIA_SINGLE_STRAND_ANNEALING","pval":0.19961,"padj":0.79183,"ES":-0.96101,"NES":-1.3057,"nMoreExtreme":8962,"size":8,"leadingEdge":["BLM"]} {"pathway":"GO_WOUND_HEALING_SPREADING_OF_EPIDERMAL_CELLS","pval":0.02629,"padj":0.40796,"ES":-0.98814,"NES":-1.30574,"nMoreExtreme":1066,"size":15,"leadingEdge":["HBEGF"]} {"pathway":"GO_TRANS_SYNAPTIC_SIGNALING_BY_TRANS_SYNAPTIC_COMPLEX","pval":0.46812,"padj":0.90738,"ES":-0.92253,"NES":-1.30636,"nMoreExtreme":21688,"size":6,"leadingEdge":["IL1RAP"]} {"pathway":"GO_CHONDROITIN_SULFATE_METABOLIC_PROCESS","pval":0.46778,"padj":0.90738,"ES":-0.92258,"NES":-1.30643,"nMoreExtreme":21672,"size":6,"leadingEdge":["DSEL"]} {"pathway":"GO_SMOOTHENED_SIGNALING_PATHWAY","pval":0.04671,"padj":0.53858,"ES":-0.67504,"NES":-1.30727,"nMoreExtreme":905,"size":117,"leadingEdge":["IFT122","GLIS2","PRKACB","RUNX2","IFT172","DISP1","CC2D2A","EVC","STIL","BMP4","WNT10B","ULK3"]} {"pathway":"GO_LOW_DENSITY_LIPOPROTEIN_RECEPTOR_PARTICLE_METABOLIC_PROCESS","pval":0.07063,"padj":0.62017,"ES":-0.96494,"NES":-1.30731,"nMoreExtreme":2724,"size":19,"leadingEdge":["AP2A2"]} {"pathway":"GO_MEGAKARYOCYTE_DEVELOPMENT","pval":0.0148,"padj":0.31281,"ES":-0.99449,"NES":-1.30763,"nMoreExtreme":617,"size":13,"leadingEdge":["TAL1"]} {"pathway":"GO_NUCLEAR_ENVELOPE_ORGANIZATION","pval":0.11206,"padj":0.69864,"ES":-0.78613,"NES":-1.308,"nMoreExtreme":3323,"size":50,"leadingEdge":["CDK1","PRKCA","CCNB2","PLK1","LMNA"]} {"pathway":"GO_REGULATION_OF_GLUCOCORTICOID_BIOSYNTHETIC_PROCESS","pval":0.45711,"padj":0.90517,"ES":-0.9241,"NES":-1.30858,"nMoreExtreme":21178,"size":6,"leadingEdge":["BMP2"]} {"pathway":"GO_CORTISOL_BIOSYNTHETIC_PROCESS","pval":0.45711,"padj":0.90517,"ES":-0.9241,"NES":-1.30858,"nMoreExtreme":21178,"size":6,"leadingEdge":["BMP2"]} {"pathway":"GO_REGULATION_OF_ALDOSTERONE_METABOLIC_PROCESS","pval":0.45683,"padj":0.90517,"ES":-0.92416,"NES":-1.30866,"nMoreExtreme":21165,"size":6,"leadingEdge":["BMP6","BMP2"]} {"pathway":"GO_BONE_MINERALIZATION_INVOLVED_IN_BONE_MATURATION","pval":0.45683,"padj":0.90517,"ES":-0.92416,"NES":-1.30866,"nMoreExtreme":21165,"size":6,"leadingEdge":["RFLNB","BMP2"]} {"pathway":"GO_CHROMOSOME_MOVEMENT_TOWARDS_SPINDLE_POLE","pval":0.30119,"padj":0.85813,"ES":-0.94646,"NES":-1.30869,"nMoreExtreme":13747,"size":7,"leadingEdge":["DLGAP5","CENPE"]} {"pathway":"GO_ERYTHROCYTE_MATURATION","pval":0.01795,"padj":0.35229,"ES":-0.99449,"NES":-1.30908,"nMoreExtreme":769,"size":11,"leadingEdge":["TAL1"]} {"pathway":"GO_NUCLEOBASE_BIOSYNTHETIC_PROCESS","pval":0.06689,"padj":0.60476,"ES":-0.96627,"NES":-1.30911,"nMoreExtreme":2580,"size":19,"leadingEdge":["SHMT1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS","pval":0.09996,"padj":0.67014,"ES":-0.97758,"NES":-1.30948,"nMoreExtreme":4409,"size":9,"leadingEdge":["KANK2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY","pval":0.09937,"padj":0.66778,"ES":-0.97769,"NES":-1.30963,"nMoreExtreme":4383,"size":9,"leadingEdge":["LBH","BRCA1","KANK2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_GASTRULATION","pval":0.29251,"padj":0.85245,"ES":-0.94764,"NES":-1.31033,"nMoreExtreme":13351,"size":7,"leadingEdge":["SOX17","FZD7"]} {"pathway":"GO_SHORT_TERM_MEMORY","pval":0.29214,"padj":0.85228,"ES":-0.94769,"NES":-1.3104,"nMoreExtreme":13334,"size":7,"leadingEdge":["CUX2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SYNAPSE_MATURATION","pval":0.17701,"padj":0.77529,"ES":-0.96455,"NES":-1.31051,"nMoreExtreme":7947,"size":8,"leadingEdge":["CDC20"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_UBIQUITIN_PROTEIN_LIGASE_ACTIVITY","pval":0.17538,"padj":0.77529,"ES":-0.96488,"NES":-1.31097,"nMoreExtreme":7874,"size":8,"leadingEdge":["MAD2L1","FBXO5"]} {"pathway":"GO_BIOTIN_METABOLIC_PROCESS","pval":0.09302,"padj":0.66428,"ES":-0.97882,"NES":-1.31113,"nMoreExtreme":4103,"size":9,"leadingEdge":["PC"]} {"pathway":"GO_REGULATION_OF_CLATHRIN_DEPENDENT_ENDOCYTOSIS","pval":0.01649,"padj":0.33082,"ES":-0.9923,"NES":-1.31124,"nMoreExtreme":668,"size":15,"leadingEdge":["DAB2"]} {"pathway":"GO_CEREBELLAR_CORTEX_MORPHOGENESIS","pval":0.1556,"padj":0.75836,"ES":-0.92928,"NES":-1.31127,"nMoreExtreme":5705,"size":24,"leadingEdge":["DLL1","KIF14"]} {"pathway":"GO_INOSITOL_METABOLIC_PROCESS","pval":0.28498,"padj":0.84765,"ES":-0.9487,"NES":-1.3118,"nMoreExtreme":13007,"size":7,"leadingEdge":["ITPKA"]} {"pathway":"GO_RESPONSE_TO_LIGHT_INTENSITY","pval":0.28417,"padj":0.84677,"ES":-0.94882,"NES":-1.31196,"nMoreExtreme":12970,"size":7,"leadingEdge":["CAT"]} {"pathway":"GO_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY","pval":0.1701,"padj":0.77295,"ES":-0.96589,"NES":-1.31234,"nMoreExtreme":7637,"size":8,"leadingEdge":["PRKCA"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELL_MATURATION","pval":0.16979,"padj":0.77295,"ES":-0.9659,"NES":-1.31234,"nMoreExtreme":7623,"size":8,"leadingEdge":["BCL2"]} {"pathway":"GO_ROOF_OF_MOUTH_DEVELOPMENT","pval":0.07613,"padj":0.63368,"ES":-0.73345,"NES":-1.31276,"nMoreExtreme":1931,"size":72,"leadingEdge":["EPHB3","DHRS3","SGPL1","BNC2","TGFBR3","SNAI1","FOXE1","IFT172","SKI"]} {"pathway":"GO_ENDOPLASMIC_RETICULUM_TUBULAR_NETWORK_ORGANIZATION","pval":0.02252,"padj":0.3799,"ES":-0.98859,"NES":-1.31329,"nMoreExtreme":902,"size":16,"leadingEdge":["REEP1"]} {"pathway":"GO_DNA_DAMAGE_INDUCED_PROTEIN_PHOSPHORYLATION","pval":0.16478,"padj":0.76986,"ES":-0.96674,"NES":-1.31349,"nMoreExtreme":7398,"size":8,"leadingEdge":["MAP2K6","CHEK1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SPINDLE_CHECKPOINT","pval":0.27501,"padj":0.83769,"ES":-0.95005,"NES":-1.31367,"nMoreExtreme":12552,"size":7,"leadingEdge":["MAD2L1","NDC80","XRCC3"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME_CENTROMERIC_REGION","pval":0.10639,"padj":0.68387,"ES":-0.94604,"NES":-1.31369,"nMoreExtreme":3981,"size":22,"leadingEdge":["CDT1","CDK1","NDC80","AURKB","BUB1B","HASPIN","TTK","KNL1","CENPA"]} {"pathway":"GO_REGULATION_OF_COENZYME_METABOLIC_PROCESS","pval":0.00286,"padj":0.1242,"ES":-0.9991,"NES":-1.31381,"nMoreExtreme":120,"size":12,"leadingEdge":["PDK4"]} {"pathway":"GO_AGGREPHAGY","pval":0.08291,"padj":0.64752,"ES":-0.98084,"NES":-1.31384,"nMoreExtreme":3657,"size":9,"leadingEdge":["MAP1LC3C"]} {"pathway":"GO_REGULATION_OF_SEQUESTERING_OF_TRIGLYCERIDE","pval":0.08237,"padj":0.64602,"ES":-0.98101,"NES":-1.31407,"nMoreExtreme":3633,"size":9,"leadingEdge":["LPL"]} {"pathway":"GO_HISTONE_H4_K20_TRIMETHYLATION","pval":0.42675,"padj":0.8986,"ES":-0.92826,"NES":-1.31447,"nMoreExtreme":19771,"size":6,"leadingEdge":["KMT5C"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CENTROSOME_DUPLICATION","pval":0.1577,"padj":0.76265,"ES":-0.96797,"NES":-1.31517,"nMoreExtreme":7080,"size":8,"leadingEdge":["PLK4"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_EPIDERMIS_DEVELOPMENT","pval":0.07716,"padj":0.63581,"ES":-0.98202,"NES":-1.31542,"nMoreExtreme":3403,"size":9,"leadingEdge":["DLL1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_DRUG","pval":0.42178,"padj":0.89612,"ES":-0.92899,"NES":-1.3155,"nMoreExtreme":19541,"size":6,"leadingEdge":["FOXO3"]} {"pathway":"GO_MITOTIC_METAPHASE_PLATE_CONGRESSION","pval":0.11912,"padj":0.70349,"ES":-0.81799,"NES":-1.31564,"nMoreExtreme":3709,"size":43,"leadingEdge":["CDT1","CDCA5","NUF2","NDC80","KIFC1","KIF14","KIF2C","CDCA8","CENPE","KIF22"]} {"pathway":"GO_EXOGENOUS_DRUG_CATABOLIC_PROCESS","pval":0.15204,"padj":0.75292,"ES":-0.96893,"NES":-1.31646,"nMoreExtreme":6826,"size":8,"leadingEdge":["CYP2S1"]} {"pathway":"GO_REGULATION_OF_CELL_ADHESION_MOLECULE_PRODUCTION","pval":0.41591,"padj":0.89503,"ES":-0.92981,"NES":-1.31666,"nMoreExtreme":19269,"size":6,"leadingEdge":["COLEC12"]} {"pathway":"GO_MAMMARY_GLAND_EPITHELIAL_CELL_DIFFERENTIATION","pval":0.00012,"padj":0.01512,"ES":-0.99994,"NES":-1.31677,"nMoreExtreme":4,"size":14,"leadingEdge":["LBH"]} {"pathway":"GO_HEMIDESMOSOME_ASSEMBLY","pval":0.02516,"padj":0.40148,"ES":-0.9932,"NES":-1.31679,"nMoreExtreme":1095,"size":10,"leadingEdge":["LAMB3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MITOCHONDRIAL_FUSION","pval":0.4144,"padj":0.89503,"ES":-0.93,"NES":-1.31694,"nMoreExtreme":19199,"size":6,"leadingEdge":["PRKN"]} {"pathway":"GO_FREE_UBIQUITIN_CHAIN_POLYMERIZATION","pval":0.41386,"padj":0.89503,"ES":-0.93006,"NES":-1.31702,"nMoreExtreme":19174,"size":6,"leadingEdge":["UBE2C","PRKN"]} {"pathway":"GO_ENDOTHELIAL_CELL_FATE_COMMITMENT","pval":0.25899,"padj":0.82758,"ES":-0.95248,"NES":-1.31702,"nMoreExtreme":11821,"size":7,"leadingEdge":["NRP1","DLL1"]} {"pathway":"GO_SCHWANN_CELL_DEVELOPMENT","pval":0.11514,"padj":0.70006,"ES":-0.94101,"NES":-1.31707,"nMoreExtreme":4269,"size":23,"leadingEdge":["SH3TC2","SKI"]} {"pathway":"GO_AMINO_ACID_BETAINE_BIOSYNTHETIC_PROCESS","pval":0.41118,"padj":0.89503,"ES":-0.93039,"NES":-1.31749,"nMoreExtreme":19050,"size":6,"leadingEdge":["SHMT1","ALDH7A1"]} {"pathway":"GO_FEMALE_MEIOTIC_NUCLEAR_DIVISION","pval":0.17766,"padj":0.77529,"ES":-0.91796,"NES":-1.3177,"nMoreExtreme":6398,"size":26,"leadingEdge":["TOP2A","MEIKIN","NCAPH","TTK","FBXO5","TRIP13","PLK1"]} {"pathway":"GO_MAINTENANCE_OF_DNA_REPEAT_ELEMENTS","pval":0.40972,"padj":0.89503,"ES":-0.93056,"NES":-1.31773,"nMoreExtreme":18982,"size":6,"leadingEdge":["MSH2"]} {"pathway":"GO_SPERMATID_DIFFERENTIATION","pval":0.0613,"padj":0.58982,"ES":-0.71413,"NES":-1.318,"nMoreExtreme":1428,"size":86,"leadingEdge":["TMEM119","DMC1","OCA2","FANCG","KNL1","HMGB2","TRIP13","CFAP44","CCDC136"]} {"pathway":"GO_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_INVOLVED_IN_ENDOCARDIAL_CUSHION_FORMATION","pval":0.40732,"padj":0.89503,"ES":-0.9309,"NES":-1.31821,"nMoreExtreme":18871,"size":6,"leadingEdge":["ENG"]} {"pathway":"GO_SEPTUM_PRIMUM_DEVELOPMENT","pval":0.407,"padj":0.89503,"ES":-0.93096,"NES":-1.31829,"nMoreExtreme":18856,"size":6,"leadingEdge":["GJA5"]} {"pathway":"GO_REGULATION_OF_DNA_DAMAGE_CHECKPOINT","pval":0.02436,"padj":0.39639,"ES":-0.98628,"NES":-1.31831,"nMoreExtreme":963,"size":17,"leadingEdge":["WDR76"]} {"pathway":"GO_DNA_REPLICATION_DEPENDENT_NUCLEOSOME_ORGANIZATION","pval":0.14169,"padj":0.73885,"ES":-0.97067,"NES":-1.31883,"nMoreExtreme":6361,"size":8,"leadingEdge":["CHAF1B","ASF1B","CHAF1A"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_ACIDIC_PH","pval":0.14166,"padj":0.73885,"ES":-0.97072,"NES":-1.3189,"nMoreExtreme":6360,"size":8,"leadingEdge":["PKD1L3"]} {"pathway":"GO_PERICARDIUM_MORPHOGENESIS","pval":0.24686,"padj":0.82387,"ES":-0.95415,"NES":-1.31934,"nMoreExtreme":11267,"size":7,"leadingEdge":["FLRT3"]} {"pathway":"GO_REGULATION_OF_PHOSPHATE_TRANSPORT","pval":0.40119,"padj":0.89503,"ES":-0.9318,"NES":-1.31948,"nMoreExtreme":18587,"size":6,"leadingEdge":["FGFR1","ROS1"]} {"pathway":"GO_HINDLIMB_MORPHOGENESIS","pval":0.1291,"padj":0.72213,"ES":-0.93516,"NES":-1.31957,"nMoreExtreme":4733,"size":24,"leadingEdge":["BMP4"]} {"pathway":"GO_REGULATION_OF_RESPONSE_TO_FOOD","pval":0.01564,"padj":0.3215,"ES":-0.99545,"NES":-1.31977,"nMoreExtreme":680,"size":10,"leadingEdge":["GHRL"]} {"pathway":"GO_REGULATION_OF_APPETITE","pval":0.01564,"padj":0.3215,"ES":-0.99545,"NES":-1.31977,"nMoreExtreme":680,"size":10,"leadingEdge":["GHRL"]} {"pathway":"GO_GROWTH_HORMONE_SECRETION","pval":0.01564,"padj":0.3215,"ES":-0.99545,"NES":-1.31977,"nMoreExtreme":680,"size":10,"leadingEdge":["GHRL"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PEPTIDYL_LYSINE_ACETYLATION","pval":0.02188,"padj":0.37476,"ES":-0.98752,"NES":-1.31997,"nMoreExtreme":865,"size":17,"leadingEdge":["BRCA1"]} {"pathway":"GO_RESPONSE_TO_POTASSIUM_ION","pval":0.06093,"padj":0.58982,"ES":-0.9855,"NES":-1.32009,"nMoreExtreme":2687,"size":9,"leadingEdge":["CRHBP"]} {"pathway":"GO_ACETYL_COA_BIOSYNTHETIC_PROCESS_FROM_PYRUVATE","pval":0.00202,"padj":0.0989,"ES":-0.9991,"NES":-1.32023,"nMoreExtreme":81,"size":15,"leadingEdge":["PDK4"]} {"pathway":"GO_MITOTIC_DNA_REPLICATION_CHECKPOINT","pval":0.06032,"padj":0.58568,"ES":-0.98562,"NES":-1.32024,"nMoreExtreme":2660,"size":9,"leadingEdge":["CDC6","CLSPN","TICRR","ORC1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT","pval":0.39567,"padj":0.89503,"ES":-0.93258,"NES":-1.3206,"nMoreExtreme":18331,"size":6,"leadingEdge":["CD24"]} {"pathway":"GO_MITOTIC_SISTER_CHROMATID_COHESION","pval":0.06903,"padj":0.61412,"ES":-0.96008,"NES":-1.32208,"nMoreExtreme":2606,"size":21,"leadingEdge":["DSCC1","CDCA5","HASPIN","SGO1","CDC20","SLF1"]} {"pathway":"GO_BLOOD_VESSEL_ENDOTHELIAL_CELL_DIFFERENTIATION","pval":0.23229,"padj":0.81508,"ES":-0.95646,"NES":-1.32252,"nMoreExtreme":10602,"size":7,"leadingEdge":["NRP1","DLL1","HEY1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_EXECUTION_PHASE_OF_APOPTOSIS","pval":0.12712,"padj":0.72213,"ES":-0.97342,"NES":-1.32257,"nMoreExtreme":5707,"size":8,"leadingEdge":["FZD3"]} {"pathway":"GO_REGULATION_OF_SEQUESTERING_OF_ZINC_ION","pval":0.45923,"padj":0.90517,"ES":-0.8791,"NES":-1.32261,"nMoreExtreme":22022,"size":4,"leadingEdge":["SLC30A2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NUCLEAR_CELL_CYCLE_DNA_REPLICATION","pval":0.38019,"padj":0.89036,"ES":-0.93466,"NES":-1.32354,"nMoreExtreme":17614,"size":6,"leadingEdge":["FGFR1","CDC7"]} {"pathway":"GO_POSITIVE_REGULATION_OF_BONE_DEVELOPMENT","pval":0.12316,"padj":0.7123,"ES":-0.97421,"NES":-1.32364,"nMoreExtreme":5529,"size":8,"leadingEdge":["TMEM119","GHRL","TNFSF11"]} {"pathway":"GO_REGULATION_OF_INTERLEUKIN_18_PRODUCTION","pval":0.49939,"padj":0.91927,"ES":-0.90832,"NES":-1.32373,"nMoreExtreme":23515,"size":5,"leadingEdge":["NLRP12"]} {"pathway":"GO_REGULATION_OF_DOPAMINERGIC_NEURON_DIFFERENTIATION","pval":0.22591,"padj":0.81244,"ES":-0.95741,"NES":-1.32384,"nMoreExtreme":10311,"size":7,"leadingEdge":["TIAM1"]} {"pathway":"GO_ALANINE_TRANSPORT","pval":0.37702,"padj":0.89036,"ES":-0.93517,"NES":-1.32425,"nMoreExtreme":17467,"size":6,"leadingEdge":["SLC36A1"]} {"pathway":"GO_COLLECTING_DUCT_DEVELOPMENT","pval":0.37663,"padj":0.89036,"ES":-0.93522,"NES":-1.32433,"nMoreExtreme":17449,"size":6,"leadingEdge":["BMP4"]} {"pathway":"GO_TRACHEA_FORMATION","pval":0.37663,"padj":0.89036,"ES":-0.93522,"NES":-1.32433,"nMoreExtreme":17449,"size":6,"leadingEdge":["BMP4"]} {"pathway":"GO_BMP_SIGNALING_PATHWAY_INVOLVED_IN_HEART_DEVELOPMENT","pval":0.37663,"padj":0.89036,"ES":-0.93522,"NES":-1.32433,"nMoreExtreme":17449,"size":6,"leadingEdge":["BMP4"]} {"pathway":"GO_PHARYNGEAL_ARCH_ARTERY_MORPHOGENESIS","pval":0.37663,"padj":0.89036,"ES":-0.93522,"NES":-1.32433,"nMoreExtreme":17449,"size":6,"leadingEdge":["BMP4"]} {"pathway":"GO_METANEPHRIC_S_SHAPED_BODY_MORPHOGENESIS","pval":0.37663,"padj":0.89036,"ES":-0.93522,"NES":-1.32433,"nMoreExtreme":17449,"size":6,"leadingEdge":["BMP4"]} {"pathway":"GO_PATTERN_SPECIFICATION_INVOLVED_IN_KIDNEY_DEVELOPMENT","pval":0.37622,"padj":0.89036,"ES":-0.93528,"NES":-1.32441,"nMoreExtreme":17430,"size":6,"leadingEdge":["IRX3","BMP4"]} {"pathway":"GO_REGULATION_OF_HEMATOPOIETIC_STEM_CELL_PROLIFERATION","pval":0.22239,"padj":0.80586,"ES":-0.95803,"NES":-1.3247,"nMoreExtreme":10150,"size":7,"leadingEdge":["KITLG","ACE"]} {"pathway":"GO_FEMALE_MEIOSIS_CHROMOSOME_SEGREGATION","pval":0.37382,"padj":0.89036,"ES":-0.93562,"NES":-1.32489,"nMoreExtreme":17319,"size":6,"leadingEdge":["MEIKIN","NCAPH","TTK","PLK1","NCAPH2"]} {"pathway":"GO_MALE_SEX_DETERMINATION","pval":0.11741,"padj":0.70191,"ES":-0.97517,"NES":-1.32494,"nMoreExtreme":5271,"size":8,"leadingEdge":["INSR"]} {"pathway":"GO_MEIOTIC_CHROMOSOME_CONDENSATION","pval":0.37346,"padj":0.89036,"ES":-0.93567,"NES":-1.32497,"nMoreExtreme":17302,"size":6,"leadingEdge":["NCAPH","NCAPD3","SMC4","SMC2","NCAPD2","NCAPH2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_NUCLEAR_DIVISION","pval":0.0967,"padj":0.66591,"ES":-0.78718,"NES":-1.32506,"nMoreExtreme":2803,"size":53,"leadingEdge":["CDT1","MAD2L1","NDC80","AURKB","BUB1B","CENPF","TTK","CHEK1","FBXO5","BUB1","CDC20","TRIP13","FBXO43","PLK1","KIF25","XRCC3"]} {"pathway":"GO_BASE_EXCISION_REPAIR","pval":0.11741,"padj":0.70191,"ES":-0.83182,"NES":-1.32508,"nMoreExtreme":3716,"size":41,"leadingEdge":["RECQL4","FEN1","NEIL3","UNG","POLQ","DNA2","PARP2","POLE"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_CHROMATIN","pval":0.13546,"padj":0.73185,"ES":-0.93071,"NES":-1.32516,"nMoreExtreme":4916,"size":25,"leadingEdge":["ESCO2","CDCA5","MCM8","PLK1","MSH2"]} {"pathway":"GO_RESPONSE_TO_GONADOTROPIN_RELEASING_HORMONE","pval":0.37173,"padj":0.89036,"ES":-0.9359,"NES":-1.32529,"nMoreExtreme":17222,"size":6,"leadingEdge":["CRHBP","MGARP"]} {"pathway":"GO_ROSTROCAUDAL_NEURAL_TUBE_PATTERNING","pval":0.21693,"padj":0.80167,"ES":-0.95884,"NES":-1.32582,"nMoreExtreme":9901,"size":7,"leadingEdge":["SSBP3","SOX17"]} {"pathway":"GO_GASTRIC_EMPTYING","pval":0.00949,"padj":0.25145,"ES":-0.99545,"NES":-1.32633,"nMoreExtreme":473,"size":1,"leadingEdge":["GHRL"]} {"pathway":"GO_REGULATION_OF_MAINTENANCE_OF_SISTER_CHROMATID_COHESION","pval":0.21115,"padj":0.79831,"ES":-0.95983,"NES":-1.32718,"nMoreExtreme":9637,"size":7,"leadingEdge":["SLF1"]} {"pathway":"GO_SURFACTANT_HOMEOSTASIS","pval":0.36012,"padj":0.89036,"ES":-0.93758,"NES":-1.32768,"nMoreExtreme":16684,"size":6,"leadingEdge":["EPAS1","RCN3"]} {"pathway":"GO_HETEROCHROMATIN_ASSEMBLY","pval":0.03463,"padj":0.47524,"ES":-0.99146,"NES":-1.32807,"nMoreExtreme":1527,"size":9,"leadingEdge":["HELLS"]} {"pathway":"GO_PEPTIDYL_LYSINE_METHYLATION","pval":0.04059,"padj":0.51641,"ES":-0.69408,"NES":-1.32866,"nMoreExtreme":820,"size":109,"leadingEdge":["BRCA1","SUV39H2","SMYD3","MYB","LMNA","JARID2","SETD6","KMT5C"]} {"pathway":"GO_REGULATION_OF_OOGENESIS","pval":0.10258,"padj":0.67367,"ES":-0.97798,"NES":-1.32875,"nMoreExtreme":4605,"size":8,"leadingEdge":["PDE3A"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_FATTY_ACID_TRANSPORT","pval":0.35358,"padj":0.888,"ES":-0.93843,"NES":-1.32887,"nMoreExtreme":16381,"size":6,"leadingEdge":["THBS1","IRS2"]} {"pathway":"GO_INTRASPECIES_INTERACTION_BETWEEN_ORGANISMS","pval":0.12859,"padj":0.72213,"ES":-0.85904,"NES":-1.32893,"nMoreExtreme":4244,"size":36,"leadingEdge":["CX3CR1","DNAJC9"]} {"pathway":"GO_VENTRICULAR_COMPACT_MYOCARDIUM_MORPHOGENESIS","pval":0.20225,"padj":0.79569,"ES":-0.96129,"NES":-1.3292,"nMoreExtreme":9231,"size":7,"leadingEdge":["TGFBR3"]} {"pathway":"GO_FORMATION_OF_TRANSLATION_PREINITIATION_COMPLEX","pval":0.02779,"padj":0.41718,"ES":-0.99303,"NES":-1.33018,"nMoreExtreme":1225,"size":9,"leadingEdge":["TICRR"]} {"pathway":"GO_PYRIMIDINE_DEOXYRIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS","pval":0.34456,"padj":0.88224,"ES":-0.93978,"NES":-1.33078,"nMoreExtreme":15963,"size":6,"leadingEdge":["TYMS","SHMT1","DUT"]} {"pathway":"GO_MULTI_ORGANISM_BEHAVIOR","pval":0.10303,"padj":0.6741,"ES":-0.81115,"NES":-1.33103,"nMoreExtreme":3111,"size":47,"leadingEdge":["CX3CR1","CRHBP","DNAJC9","CNTFR"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVITY","pval":0.19342,"padj":0.79001,"ES":-0.96264,"NES":-1.33107,"nMoreExtreme":8828,"size":7,"leadingEdge":["CACNA1D"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TOR_SIGNALING","pval":0.10497,"padj":0.68027,"ES":-0.81527,"NES":-1.33116,"nMoreExtreme":3190,"size":46,"leadingEdge":["DEPTOR","CASTOR1","SESN3","SESN1","DDIT4","RNF152"]} {"pathway":"GO_FEMALE_MEIOSIS_I","pval":0.19222,"padj":0.79001,"ES":-0.96286,"NES":-1.33138,"nMoreExtreme":8773,"size":7,"leadingEdge":["FBXO5","TRIP13"]} {"pathway":"GO_ACTOMYOSIN_CONTRACTILE_RING_ORGANIZATION","pval":0.3416,"padj":0.87818,"ES":-0.94022,"NES":-1.33141,"nMoreExtreme":15826,"size":6,"leadingEdge":["ANLN","RACGAP1"]} {"pathway":"GO_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION","pval":0.10028,"padj":0.67104,"ES":-0.80753,"NES":-1.33159,"nMoreExtreme":3006,"size":48,"leadingEdge":["DAB2","TTK","TGFBR3","LDLRAD4","GDF7","BMP6","BMP8A","BMP4","ENG","BMP2"]} {"pathway":"GO_MONOSACCHARIDE_METABOLIC_PROCESS","pval":0.0352,"padj":0.47945,"ES":-0.68268,"NES":-1.33161,"nMoreExtreme":660,"size":123,"leadingEdge":["PDK4","GHRL","SLC45A3","NISCH","INSR","KHK","PASK","IGFBP3","IRS2","PPP1R3G","PRKN"]} {"pathway":"GO_MEMBRANE_DEPOLARIZATION_DURING_AV_NODE_CELL_ACTION_POTENTIAL","pval":0.49629,"padj":0.91907,"ES":-0.91433,"NES":-1.33249,"nMoreExtreme":23369,"size":5,"leadingEdge":["SCN5A"]} {"pathway":"GO_RESPONSE_TO_CELL_CYCLE_CHECKPOINT_SIGNALING","pval":0.08801,"padj":0.65627,"ES":-0.98073,"NES":-1.3325,"nMoreExtreme":3951,"size":8,"leadingEdge":["EME1"]} {"pathway":"GO_REGULATION_OF_ATRIAL_CARDIAC_MUSCLE_CELL_MEMBRANE_DEPOLARIZATION","pval":0.49598,"padj":0.91907,"ES":-0.91439,"NES":-1.33257,"nMoreExtreme":23354,"size":5,"leadingEdge":["GJA5","SCN5A"]} {"pathway":"GO_REGULATION_OF_VENTRICULAR_CARDIAC_MUSCLE_CELL_MEMBRANE_DEPOLARIZATION","pval":0.49598,"padj":0.91907,"ES":-0.91439,"NES":-1.33257,"nMoreExtreme":23354,"size":5,"leadingEdge":["GJA5","SCN5A"]} {"pathway":"GO_BUNDLE_OF_HIS_CELL_TO_PURKINJE_MYOCYTE_SIGNALING","pval":0.49598,"padj":0.91907,"ES":-0.91439,"NES":-1.33257,"nMoreExtreme":23354,"size":5,"leadingEdge":["GJA5","SCN5A"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_RECEPTOR_BIOSYNTHETIC_PROCESS","pval":0.49523,"padj":0.91907,"ES":-0.9145,"NES":-1.33273,"nMoreExtreme":23319,"size":5,"leadingEdge":["ITGB3"]} {"pathway":"GO_APOLIPOPROTEIN_A_I_MEDIATED_SIGNALING_PATHWAY","pval":0.49523,"padj":0.91907,"ES":-0.9145,"NES":-1.33273,"nMoreExtreme":23319,"size":5,"leadingEdge":["ITGB3"]} {"pathway":"GO_CHROMOSOME_LOCALIZATION","pval":0.07183,"padj":0.62112,"ES":-0.75505,"NES":-1.33339,"nMoreExtreme":1884,"size":67,"leadingEdge":["CDT1","CDCA5","NUF2","NDC80","CENPF","KIFC1","SPAG5","KIF14","KIF2C","DLGAP5","CDCA8","FAM83D","CENPE","CENPQ","KIF22"]} {"pathway":"GO_DEPYRIMIDINATION","pval":0.08467,"padj":0.65213,"ES":-0.98146,"NES":-1.33349,"nMoreExtreme":3801,"size":8,"leadingEdge":["UNG"]} {"pathway":"GO_NEURAL_TUBE_PATTERNING","pval":0.14544,"padj":0.74662,"ES":-0.89251,"NES":-1.33374,"nMoreExtreme":5022,"size":31,"leadingEdge":["SSBP3","IFT122","SOX17","PRKACB","BMP4"]} {"pathway":"GO_NEURAL_PLATE_REGIONALIZATION","pval":0.32923,"padj":0.87227,"ES":-0.94202,"NES":-1.33396,"nMoreExtreme":15253,"size":6,"leadingEdge":["SSBP3","CELSR2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY","pval":0.49058,"padj":0.91801,"ES":-0.91534,"NES":-1.33396,"nMoreExtreme":23100,"size":5,"leadingEdge":["OPRL1"]} {"pathway":"GO_NEUTROPHIL_MEDIATED_CYTOTOXICITY","pval":0.49037,"padj":0.91801,"ES":-0.9154,"NES":-1.33404,"nMoreExtreme":23090,"size":5,"leadingEdge":["DNASE1"]} {"pathway":"GO_CARDIAC_CELL_FATE_COMMITMENT","pval":0.07962,"padj":0.63757,"ES":-0.98253,"NES":-1.33494,"nMoreExtreme":3574,"size":8,"leadingEdge":["SOX17"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_STEROL_TRANSPORT","pval":0.48478,"padj":0.91689,"ES":-0.91635,"NES":-1.33543,"nMoreExtreme":22827,"size":5,"leadingEdge":["APOC1"]} {"pathway":"GO_HISTONE_THREONINE_PHOSPHORYLATION","pval":0.1746,"padj":0.77529,"ES":-0.96589,"NES":-1.33556,"nMoreExtreme":7969,"size":7,"leadingEdge":["HASPIN","PRKCA","CHEK1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_DNA_ENDOREDUPLICATION","pval":0.17156,"padj":0.77295,"ES":-0.96635,"NES":-1.33619,"nMoreExtreme":7830,"size":7,"leadingEdge":["FBXO5"]} {"pathway":"GO_ESTABLISHMENT_OF_CENTROSOME_LOCALIZATION","pval":0.16518,"padj":0.76992,"ES":-0.96736,"NES":-1.33759,"nMoreExtreme":7539,"size":7,"leadingEdge":["FHOD1"]} {"pathway":"GO_REGULATION_OF_FIBRINOLYSIS","pval":0.31069,"padj":0.86489,"ES":-0.94466,"NES":-1.3377,"nMoreExtreme":14394,"size":6,"leadingEdge":["THBD","THBS1"]} {"pathway":"GO_HISTONE_H3_K9_METHYLATION","pval":0.13576,"padj":0.73227,"ES":-0.88251,"NES":-1.33775,"nMoreExtreme":4601,"size":33,"leadingEdge":["BRCA1","SUV39H2","MYB","LMNA","JARID2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_BEHAVIOR","pval":0.30918,"padj":0.86471,"ES":-0.94483,"NES":-1.33794,"nMoreExtreme":14324,"size":6,"leadingEdge":["GHRL","RETN"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ASTROCYTE_DIFFERENTIATION","pval":0.06761,"padj":0.60666,"ES":-0.98494,"NES":-1.33822,"nMoreExtreme":3035,"size":8,"leadingEdge":["DAB1"]} {"pathway":"GO_REGULATION_OF_GLUCONEOGENESIS_BY_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER","pval":0.30789,"padj":0.86308,"ES":-0.94506,"NES":-1.33826,"nMoreExtreme":14264,"size":6,"leadingEdge":["KAT2A"]} {"pathway":"GO_REGULATION_OF_ACYL_COA_BIOSYNTHETIC_PROCESS","pval":0.0034,"padj":0.13866,"ES":-0.9991,"NES":-1.3383,"nMoreExtreme":149,"size":9,"leadingEdge":["PDK4"]} {"pathway":"GO_REGULATION_OF_HEART_RATE_BY_CHEMICAL_SIGNAL","pval":0.46992,"padj":0.9079,"ES":-0.91877,"NES":-1.33895,"nMoreExtreme":22127,"size":5,"leadingEdge":["KCNH2"]} {"pathway":"GO_REGULATION_OF_CELL_DIVISION","pval":0.03013,"padj":0.43469,"ES":-0.67933,"NES":-1.33913,"nMoreExtreme":535,"size":133,"leadingEdge":["LBH","E2F8","TAL1","CDC6","KIF18B","PRC1","OSM","AURKB","SOX17","DLL1","HTR2B","PDGFC","CIT","KIF14","ORC6","E2F7","ASPM","PPBP","KIF20A","BLM","PLK1"]} {"pathway":"GO_TETRAPYRROLE_CATABOLIC_PROCESS","pval":0.30186,"padj":0.85858,"ES":-0.9459,"NES":-1.33945,"nMoreExtreme":13985,"size":6,"leadingEdge":["BLVRB"]} {"pathway":"GO_LAMELLIPODIUM_ASSEMBLY","pval":0.07737,"padj":0.63581,"ES":-0.77561,"NES":-1.34029,"nMoreExtreme":2128,"size":60,"leadingEdge":["S1PR1","ABLIM3","FSCN1","ABLIM2"]} {"pathway":"GO_FOREBRAIN_NEUROBLAST_DIVISION","pval":0.29727,"padj":0.85691,"ES":-0.94657,"NES":-1.3404,"nMoreExtreme":13772,"size":6,"leadingEdge":["ASPM","FGFR1"]} {"pathway":"GO_REGULATION_OF_MESODERMAL_CELL_FATE_SPECIFICATION","pval":0.29727,"padj":0.85691,"ES":-0.94657,"NES":-1.3404,"nMoreExtreme":13772,"size":6,"leadingEdge":["SOX17","FGFR1"]} {"pathway":"GO_REGULATION_OF_MESODERMAL_CELL_DIFFERENTIATION","pval":0.29727,"padj":0.85691,"ES":-0.94657,"NES":-1.3404,"nMoreExtreme":13772,"size":6,"leadingEdge":["SOX17","FGFR1"]} {"pathway":"GO_REGULATION_OF_MESODERM_FORMATION","pval":0.29727,"padj":0.85691,"ES":-0.94657,"NES":-1.3404,"nMoreExtreme":13772,"size":6,"leadingEdge":["SOX17","FGFR1"]} {"pathway":"GO_MITOTIC_RECOMBINATION","pval":0.07423,"padj":0.62748,"ES":-0.95006,"NES":-1.3406,"nMoreExtreme":2721,"size":24,"leadingEdge":["DMC1","RAD51","BLM","XRCC3"]} {"pathway":"GO_L_METHIONINE_SALVAGE_FROM_METHYLTHIOADENOSINE","pval":0.46289,"padj":0.90517,"ES":-0.91995,"NES":-1.34067,"nMoreExtreme":21796,"size":5,"leadingEdge":["ADI1"]} {"pathway":"GO_AMINO_ACID_SALVAGE","pval":0.46289,"padj":0.90517,"ES":-0.91995,"NES":-1.34067,"nMoreExtreme":21796,"size":5,"leadingEdge":["ADI1"]} {"pathway":"GO_GLUCAN_CATABOLIC_PROCESS","pval":0.04878,"padj":0.54786,"ES":-0.96549,"NES":-1.34071,"nMoreExtreme":1825,"size":22,"leadingEdge":["G6PC"]} {"pathway":"GO_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION","pval":0.09409,"padj":0.66478,"ES":-0.8099,"NES":-1.34142,"nMoreExtreme":2806,"size":49,"leadingEdge":["E2F8","TICRR","DSCC1","CDT1","CHTF18","RFC3","RFC5","RFC4","E2F7","FBXO5","BLM","FGFR1","DONSON","CDC7","CDK2"]} {"pathway":"GO_3_PHOSPHOADENOSINE_5_PHOSPHOSULFATE_BIOSYNTHETIC_PROCESS","pval":0.45881,"padj":0.90517,"ES":-0.92057,"NES":-1.34157,"nMoreExtreme":21604,"size":5,"leadingEdge":["PAPSS2"]} {"pathway":"GO_ECTODERMAL_CELL_DIFFERENTIATION","pval":0.29008,"padj":0.85125,"ES":-0.94758,"NES":-1.34184,"nMoreExtreme":13439,"size":6,"leadingEdge":["FZD7"]} {"pathway":"GO_HINDGUT_DEVELOPMENT","pval":0.28838,"padj":0.84916,"ES":-0.94787,"NES":-1.34223,"nMoreExtreme":13360,"size":6,"leadingEdge":["IFT172"]} {"pathway":"GO_NEUTRAL_LIPID_CATABOLIC_PROCESS","pval":0.08684,"padj":0.65449,"ES":-0.94341,"NES":-1.34324,"nMoreExtreme":3151,"size":25,"leadingEdge":["LPL","PNPLA3"]} {"pathway":"GO_TELOMERE_MAINTENANCE_VIA_SEMI_CONSERVATIVE_REPLICATION","pval":0.14411,"padj":0.74343,"ES":-0.91941,"NES":-1.34327,"nMoreExtreme":5101,"size":28,"leadingEdge":["FEN1","POLE2","RFC3","RFC5","RFC4","DNA2","POLA1","POLE","PCNA","POLD2"]} {"pathway":"GO_PROTEIN_DE_ADP_RIBOSYLATION","pval":0.44898,"padj":0.90517,"ES":-0.92203,"NES":-1.3437,"nMoreExtreme":21141,"size":5,"leadingEdge":["MACROD1"]} {"pathway":"GO_REGULATION_OF_CHROMATIN_SILENCING","pval":0.0542,"padj":0.56056,"ES":-0.9603,"NES":-1.34407,"nMoreExtreme":2009,"size":23,"leadingEdge":["CDC45","ATAD2"]} {"pathway":"GO_PANTOTHENATE_METABOLIC_PROCESS","pval":0.13703,"padj":0.73301,"ES":-0.97236,"NES":-1.34451,"nMoreExtreme":6254,"size":7,"leadingEdge":["VNN1"]} {"pathway":"GO_CHORION_DEVELOPMENT","pval":0.13449,"padj":0.72971,"ES":-0.97275,"NES":-1.34505,"nMoreExtreme":6138,"size":7,"leadingEdge":["E2F8","HTRA1","E2F7"]} {"pathway":"GO_EXTRAEMBRYONIC_MEMBRANE_DEVELOPMENT","pval":0.13449,"padj":0.72971,"ES":-0.97275,"NES":-1.34505,"nMoreExtreme":6138,"size":7,"leadingEdge":["E2F8","HTRA1","E2F7"]} {"pathway":"GO_PURINE_NUCLEOSIDE_TRIPHOSPHATE_CATABOLIC_PROCESS","pval":0.27342,"padj":0.83739,"ES":-0.95,"NES":-1.34526,"nMoreExtreme":12667,"size":6,"leadingEdge":["NUDT1"]} {"pathway":"GO_PURINE_DEOXYRIBONUCLEOTIDE_CATABOLIC_PROCESS","pval":0.27342,"padj":0.83739,"ES":-0.95,"NES":-1.34526,"nMoreExtreme":12667,"size":6,"leadingEdge":["NUDT1"]} {"pathway":"GO_DOUBLE_STRAND_BREAK_REPAIR_VIA_SYNTHESIS_DEPENDENT_STRAND_ANNEALING","pval":0.27281,"padj":0.83739,"ES":-0.95011,"NES":-1.34542,"nMoreExtreme":12639,"size":6,"leadingEdge":["DMC1","RAD51","BLM","XRCC3"]} {"pathway":"GO_BLOOD_VESSEL_MATURATION","pval":0.04278,"padj":0.52235,"ES":-0.99034,"NES":-1.34555,"nMoreExtreme":1920,"size":8,"leadingEdge":["S1PR1","CDH5"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_DENDRITIC_SPINE_MORPHOGENESIS","pval":0.44004,"padj":0.90126,"ES":-0.92343,"NES":-1.34575,"nMoreExtreme":20720,"size":5,"leadingEdge":["NGEF","DNM3"]} {"pathway":"GO_FRUCTOSE_METABOLIC_PROCESS","pval":0.12928,"padj":0.72224,"ES":-0.97376,"NES":-1.34645,"nMoreExtreme":5900,"size":7,"leadingEdge":["KHK"]} {"pathway":"GO_REGULATION_OF_WNT_SIGNALING_PATHWAY_INVOLVED_IN_HEART_DEVELOPMENT","pval":0.43535,"padj":0.90091,"ES":-0.92416,"NES":-1.34681,"nMoreExtreme":20499,"size":5,"leadingEdge":["SOX17","BMP2"]} {"pathway":"GO_OUTFLOW_TRACT_MORPHOGENESIS","pval":0.07118,"padj":0.62112,"ES":-0.7746,"NES":-1.34737,"nMoreExtreme":1933,"size":62,"leadingEdge":["NRP1","DHRS3","SOX17","TGFBR3","RYR1","BMP4","GJA5","ENG","PLXND1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_HAIR_FOLLICLE_MATURATION","pval":0.43029,"padj":0.89981,"ES":-0.92484,"NES":-1.3478,"nMoreExtreme":20261,"size":5,"leadingEdge":["WNT10B"]} {"pathway":"GO_METAPHASE_PLATE_CONGRESSION","pval":0.08028,"padj":0.63992,"ES":-0.79369,"NES":-1.34794,"nMoreExtreme":2296,"size":55,"leadingEdge":["CDT1","CDCA5","NUF2","NDC80","CENPF","KIFC1","SPAG5","KIF14","KIF2C","CDCA8","FAM83D","CENPE","CENPQ","KIF22"]} {"pathway":"GO_POSITIVE_REGULATION_OF_BMP_SIGNALING_PATHWAY","pval":0.11271,"padj":0.69864,"ES":-0.93087,"NES":-1.34815,"nMoreExtreme":4023,"size":27,"leadingEdge":["BMP4","ENG"]} {"pathway":"GO_CELL_CYCLE_PROCESS","pval":0.00481,"padj":0.17559,"ES":-0.58236,"NES":-1.3482,"nMoreExtreme":0,"size":1177,"leadingEdge":["CCNE2","IQGAP3","E2F8","TOP2A","MEIKIN","E2F1","CD28","MYBL2","MCM10","SPC25","RRM2","CDKN2C","TYMS","CDC45","CDC25A","CDC6","PCLAF","CLSPN","TICRR","MCM6","RECQL4","MCM7","DSCC1","MCM4","ESCO2","DMC1","KIF18B","CDT1","LRP5","MCM2","FEN1","NCAPG","CDCA5","ZWINT","PKMYT1","CDK1","BIRC5","XRCC2","ANLN","DHFR","BRCA1","DTL","PRC1","MKI67","CCNA2","KIF11","MAD2L1","ORC1","TACC2","NUF2","POLE2","NUSAP1","GTSE1","NDC80","AURKB","MCM5","NCAPH","STMN1","CCNF","BUB1B","CENPF","WDR62","EME1","WEE1","GINS1","MYBL1","KIFC1","HASPIN","PDE3A","MND1","CDC25C","KANK2","PRKCA","RFC3","TTK","TP73","MCM8","ESPL1","SPAG5","CIT","RFC5","AUNIP","RFC4","INSR","RAD51","KIF14","DNA2","ORC6","MAP2K6","E2F7","JADE1","FOXM1","KIF2C","ASPM","KNL1","UBE2C","CTDSPL","POLA1","CENPA","DLGAP5","PLK4","SGO1","CCNB2","CHEK1","NEK2","PSMC3IP","TPX2","KIF4A","FBXO5","CDCA8","BCL2","BUB1","CDC20","NCAPD3","POLE","TRIP13","KIF20A","FZD9","FBXO43","BLM","PLK1","SLF1","NEK10","SMC4","CEP55","CDK5R1","GPR3","CDKN2B","DHCR24","KIF25","SMC2","CENPS","MCM3","LMNA","XRCC3","TP53INP1","FAM83D","TACC3","DSN1","RTTN","FGFR1","NCAPD2","CENPE","CDKN3","KAT2A","CCNE1","THBS1","NES","DDX11","HMMR","CEP72","PCNA","RCC1","RACGAP1","USP51","DONSON","CENPQ","ZNF503","DDIAS","TPD52L1","STIL","NCAPH2","BMP4","ATAD5","CDC7","KIF22","RBL1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_EARLY_ENDOSOME_TO_LATE_ENDOSOME_TRANSPORT","pval":0.03298,"padj":0.46522,"ES":-0.9923,"NES":-1.34822,"nMoreExtreme":1480,"size":8,"leadingEdge":["DAB2"]} {"pathway":"GO_NEURON_PROJECTION_MAINTENANCE","pval":0.12102,"padj":0.7062,"ES":-0.97517,"NES":-1.34839,"nMoreExtreme":5523,"size":7,"leadingEdge":["INSR"]} {"pathway":"GO_LAGGING_STRAND_ELONGATION","pval":0.42299,"padj":0.89612,"ES":-0.9259,"NES":-1.34935,"nMoreExtreme":19917,"size":5,"leadingEdge":["DNA2","POLA1","LIG1"]} {"pathway":"GO_PERIPHERAL_NERVOUS_SYSTEM_MYELIN_MAINTENANCE","pval":0.25335,"padj":0.82744,"ES":-0.95303,"NES":-1.34955,"nMoreExtreme":11737,"size":6,"leadingEdge":["SH3TC2"]} {"pathway":"GO_REGULATION_OF_METAPHASE_PLATE_CONGRESSION","pval":0.11418,"padj":0.69968,"ES":-0.9764,"NES":-1.3501,"nMoreExtreme":5211,"size":7,"leadingEdge":["SPAG5"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CAMP_DEPENDENT_PROTEIN_KINASE_ACTIVITY","pval":0.02561,"padj":0.4026,"ES":-0.99393,"NES":-1.35043,"nMoreExtreme":1149,"size":8,"leadingEdge":["PKIB"]} {"pathway":"GO_REGULATION_OF_RETINAL_GANGLION_CELL_AXON_GUIDANCE","pval":0.45625,"padj":0.90517,"ES":-0.89774,"NES":-1.35066,"nMoreExtreme":21879,"size":4,"leadingEdge":["NRP1"]} {"pathway":"GO_TELOMERE_ORGANIZATION","pval":0.02335,"padj":0.38612,"ES":-0.68012,"NES":-1.35135,"nMoreExtreme":397,"size":141,"leadingEdge":["CCNE2","PKIB","RECQL4","EXO1","FEN1","POLE2","AURKB","RFC3","RFC5","RFC4","RAD51","DNA2","POLA1","NEK2","POLE","BLM","XRCC3","CCNE1","PCNA"]} {"pathway":"GO_GLYCOGEN_BIOSYNTHETIC_PROCESS","pval":0.10522,"padj":0.68115,"ES":-0.85332,"NES":-1.35138,"nMoreExtreme":3349,"size":40,"leadingEdge":["INSR","PASK","IRS2","PPP1R3G"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CHOLESTEROL_STORAGE","pval":0.2443,"padj":0.82387,"ES":-0.95441,"NES":-1.3515,"nMoreExtreme":11318,"size":6,"leadingEdge":["LPL"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_COLLATERAL_SPROUTING","pval":0.02093,"padj":0.36542,"ES":-0.99489,"NES":-1.35173,"nMoreExtreme":939,"size":8,"leadingEdge":["FSTL4"]} {"pathway":"GO_SYNAPTIC_VESICLE_BUDDING_FROM_PRESYNAPTIC_ENDOCYTIC_ZONE_MEMBRANE","pval":0.41073,"padj":0.89503,"ES":-0.92768,"NES":-1.35194,"nMoreExtreme":19340,"size":5,"leadingEdge":["DNM1"]} {"pathway":"GO_HYPOTHALAMUS_CELL_DIFFERENTIATION","pval":0.24007,"padj":0.82313,"ES":-0.95508,"NES":-1.35245,"nMoreExtreme":11122,"size":6,"leadingEdge":["NRP1"]} {"pathway":"GO_REGULATION_OF_ARACHIDONIC_ACID_SECRETION","pval":0.23843,"padj":0.82177,"ES":-0.95528,"NES":-1.35274,"nMoreExtreme":11046,"size":6,"leadingEdge":["NTSR1"]} {"pathway":"GO_SELENIUM_COMPOUND_METABOLIC_PROCESS","pval":0.40685,"padj":0.89503,"ES":-0.92834,"NES":-1.3529,"nMoreExtreme":19157,"size":5,"leadingEdge":["SELENOP"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SECONDARY_METABOLITE_BIOSYNTHETIC_PROCESS","pval":0.23563,"padj":0.81978,"ES":-0.95573,"NES":-1.35337,"nMoreExtreme":10916,"size":6,"leadingEdge":["TYRP1"]} {"pathway":"GO_DNA_METABOLIC_PROCESS","pval":0.00079,"padj":0.0539,"ES":-0.593,"NES":-1.35372,"nMoreExtreme":0,"size":743,"leadingEdge":["CCNE2","TOP2A","CD28","MCM10","GINS2","CDC45","CDC6","PKIB","RAD54L","PCLAF","CLSPN","TICRR","MCM6","RECQL4","MCM7","TK1","EXO1","EEPD1","HELLS","MCM4","ESCO2","DMC1","CDT1","MCM2","FEN1","CDCA5","CDK1","XRCC2","BRCA1","DTL","NEIL3","ORC1","CHAF1B","POLE2","UHRF1","AURKB","MCM5","UBE2T","UNG","EME1","FANCE","TONSL","GINS1","POLQ","MND1","RFC3","TP73","MCM8","RFC5","AUNIP","RFC4","RAD51","DNA2","ORC6","FANCB","MMS22L","FOXM1","WDHD1","FANCG","CHAF1A","FANCI","PARP2","POLA1","CHEK1","NEK2","PSMC3IP","HMGB2","POLE","TRIP13","APOBEC3B","BLM","HMGB3","SLF1","CENPS","MCM3","GINS3","RAD51AP1","NUDT1","XRCC3"]} {"pathway":"GO_ENDOPLASMIC_RETICULUM_LOCALIZATION","pval":0.40283,"padj":0.89503,"ES":-0.92894,"NES":-1.35377,"nMoreExtreme":18968,"size":5,"leadingEdge":["MYO5A"]} {"pathway":"GO_VESICLE_TRANSPORT_ALONG_ACTIN_FILAMENT","pval":0.40247,"padj":0.89503,"ES":-0.92899,"NES":-1.35385,"nMoreExtreme":18951,"size":5,"leadingEdge":["FNBP1L","MYO5A"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CHROMOSOME_SEGREGATION","pval":0.0789,"padj":0.63581,"ES":-0.94336,"NES":-1.35417,"nMoreExtreme":2841,"size":26,"leadingEdge":["CDC6","CDT1","FEN1","ESPL1","DLGAP5","SLF1","DDX11"]} {"pathway":"GO_MITOCHONDRION_MORPHOGENESIS","pval":0.00067,"padj":0.0485,"ES":-0.99955,"NES":-1.3542,"nMoreExtreme":25,"size":19,"leadingEdge":["PID1"]} {"pathway":"GO_ATRIOVENTRICULAR_VALVE_FORMATION","pval":0.23206,"padj":0.81508,"ES":-0.95635,"NES":-1.35425,"nMoreExtreme":10751,"size":6,"leadingEdge":["HEY1"]} {"pathway":"GO_TYPE_I_PNEUMOCYTE_DIFFERENTIATION","pval":0.40009,"padj":0.89503,"ES":-0.92939,"NES":-1.35443,"nMoreExtreme":18839,"size":5,"leadingEdge":["THRB"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SYNAPTIC_PLASTICITY","pval":0.39895,"padj":0.89503,"ES":-0.92955,"NES":-1.35467,"nMoreExtreme":18785,"size":5,"leadingEdge":["RIN1"]} {"pathway":"GO_RESPONSE_TO_HISTAMINE","pval":0.22878,"padj":0.81508,"ES":-0.95685,"NES":-1.35496,"nMoreExtreme":10599,"size":6,"leadingEdge":["HRH1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_VESICLE_FUSION","pval":0.0102,"padj":0.25928,"ES":-0.99736,"NES":-1.35509,"nMoreExtreme":457,"size":8,"leadingEdge":["SYT1"]} {"pathway":"GO_REGULATION_OF_NK_T_CELL_PROLIFERATION","pval":0.39697,"padj":0.89503,"ES":-0.92989,"NES":-1.35516,"nMoreExtreme":18692,"size":5,"leadingEdge":["IL23A","IL18"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NEUROTRANSMITTER_UPTAKE","pval":0.39621,"padj":0.89503,"ES":-0.93,"NES":-1.35533,"nMoreExtreme":18656,"size":5,"leadingEdge":["PRKN"]} {"pathway":"GO_REGULATION_OF_SPONTANEOUS_SYNAPTIC_TRANSMISSION","pval":0.39621,"padj":0.89503,"ES":-0.93,"NES":-1.35533,"nMoreExtreme":18656,"size":5,"leadingEdge":["PRKN"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_NEURON_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY","pval":0.39621,"padj":0.89503,"ES":-0.93,"NES":-1.35533,"nMoreExtreme":18656,"size":5,"leadingEdge":["PRKN"]} {"pathway":"GO_PROTEIN_K29_LINKED_UBIQUITINATION","pval":0.3958,"padj":0.89503,"ES":-0.93006,"NES":-1.35541,"nMoreExtreme":18637,"size":5,"leadingEdge":["UBE2T","PRKN"]} {"pathway":"GO_NOREPINEPHRINE_METABOLIC_PROCESS","pval":0.3958,"padj":0.89503,"ES":-0.93006,"NES":-1.35541,"nMoreExtreme":18637,"size":5,"leadingEdge":["EPAS1","PRKN"]} {"pathway":"GO_PROTEIN_K27_LINKED_UBIQUITINATION","pval":0.3958,"padj":0.89503,"ES":-0.93006,"NES":-1.35541,"nMoreExtreme":18637,"size":5,"leadingEdge":["UBE2T","PRKN"]} {"pathway":"GO_CHROMOSOME_CONDENSATION","pval":0.09434,"padj":0.66478,"ES":-0.93594,"NES":-1.35548,"nMoreExtreme":3367,"size":27,"leadingEdge":["TOP2A","NCAPG","CDCA5","CDK1","NCAPG2","NUSAP1","NCAPH","NCAPD3","SMC4","SMC2","NCAPD2","NCAPH2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_METAPHASE_ANAPHASE_TRANSITION_OF_CELL_CYCLE","pval":0.11682,"padj":0.70159,"ES":-0.88235,"NES":-1.35571,"nMoreExtreme":3895,"size":35,"leadingEdge":["CDT1","MAD2L1","NDC80","AURKB","BUB1B","CENPF","TTK","FBXO5","BUB1","CDC20","TRIP13","PLK1","XRCC3"]} {"pathway":"GO_MRNA_3_END_PROCESSING_BY_STEM_LOOP_BINDING_AND_CLEAVAGE","pval":0.39247,"padj":0.89503,"ES":-0.93051,"NES":-1.35606,"nMoreExtreme":18480,"size":5,"leadingEdge":["LSM11"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MAMMARY_GLAND_EPITHELIAL_CELL_PROLIFERATION","pval":0.00717,"padj":0.22119,"ES":-0.99815,"NES":-1.35616,"nMoreExtreme":321,"size":8,"leadingEdge":["IQGAP3"]} {"pathway":"GO_FOREBRAIN_MORPHOGENESIS","pval":0.22248,"padj":0.80586,"ES":-0.95787,"NES":-1.35639,"nMoreExtreme":10307,"size":6,"leadingEdge":["GDF7"]} {"pathway":"GO_POSTSYNAPTIC_CYTOSKELETON_ORGANIZATION","pval":0.00586,"padj":0.19815,"ES":-0.99848,"NES":-1.35662,"nMoreExtreme":262,"size":8,"leadingEdge":["INA"]} {"pathway":"GO_POSITIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_INVOLVED_IN_ENDOCARDIAL_CUSHION_FORMATION","pval":0.38994,"padj":0.8943,"ES":-0.9309,"NES":-1.35664,"nMoreExtreme":18361,"size":5,"leadingEdge":["ENG"]} {"pathway":"GO_REGULATION_OF_MEMBRANE_DEPOLARIZATION_DURING_ACTION_POTENTIAL","pval":0.3896,"padj":0.8943,"ES":-0.93096,"NES":-1.35672,"nMoreExtreme":18345,"size":5,"leadingEdge":["GJA5"]} {"pathway":"GO_GLYCOSIDE_METABOLIC_PROCESS","pval":0.38848,"padj":0.89286,"ES":-0.93113,"NES":-1.35697,"nMoreExtreme":18292,"size":5,"leadingEdge":["AKR7A2"]} {"pathway":"GO_POLYKETIDE_METABOLIC_PROCESS","pval":0.38848,"padj":0.89286,"ES":-0.93113,"NES":-1.35697,"nMoreExtreme":18292,"size":5,"leadingEdge":["AKR7A2"]} {"pathway":"GO_TERTIARY_ALCOHOL_METABOLIC_PROCESS","pval":0.38848,"padj":0.89286,"ES":-0.93113,"NES":-1.35697,"nMoreExtreme":18292,"size":5,"leadingEdge":["AKR7A2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_METALLOPEPTIDASE_ACTIVITY","pval":0.21927,"padj":0.80281,"ES":-0.95837,"NES":-1.35711,"nMoreExtreme":10158,"size":6,"leadingEdge":["SORL1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELL_SIZE","pval":0.00425,"padj":0.1618,"ES":-0.99893,"NES":-1.35723,"nMoreExtreme":190,"size":8,"leadingEdge":["DEPTOR"]} {"pathway":"GO_LOOP_OF_HENLE_DEVELOPMENT","pval":0.21685,"padj":0.80167,"ES":-0.95876,"NES":-1.35767,"nMoreExtreme":10046,"size":6,"leadingEdge":["DLL1","IRX3"]} {"pathway":"GO_GLUCOSE_6_PHOSPHATE_METABOLIC_PROCESS","pval":0.00243,"padj":0.11208,"ES":-0.99949,"NES":-1.35799,"nMoreExtreme":108,"size":8,"leadingEdge":["G6PC"]} {"pathway":"GO_L_SERINE_BIOSYNTHETIC_PROCESS","pval":0.08318,"padj":0.64772,"ES":-0.9823,"NES":-1.35826,"nMoreExtreme":3796,"size":7,"leadingEdge":["SERINC5"]} {"pathway":"GO_REGULATION_OF_SMAD_PROTEIN_COMPLEX_ASSEMBLY","pval":0.21447,"padj":0.7999,"ES":-0.95921,"NES":-1.3583,"nMoreExtreme":9936,"size":6,"leadingEdge":["LDLRAD4"]} {"pathway":"GO_MODULATION_BY_HOST_OF_SYMBIONT_MOLECULAR_FUNCTION","pval":0.38098,"padj":0.89036,"ES":-0.93231,"NES":-1.35868,"nMoreExtreme":17939,"size":5,"leadingEdge":["PTX3"]} {"pathway":"GO_PROTEIN_TRANSPORT_INTO_MEMBRANE_RAFT","pval":0.3793,"padj":0.89036,"ES":-0.93259,"NES":-1.35909,"nMoreExtreme":17860,"size":5,"leadingEdge":["CD24"]} {"pathway":"GO_ENDOCARDIUM_MORPHOGENESIS","pval":0.45542,"padj":0.90517,"ES":-0.90394,"NES":-1.35998,"nMoreExtreme":21839,"size":4,"leadingEdge":["SOX17"]} {"pathway":"GO_CLEAVAGE_FURROW_FORMATION","pval":0.07641,"padj":0.63457,"ES":-0.98359,"NES":-1.36004,"nMoreExtreme":3487,"size":7,"leadingEdge":["AURKB"]} {"pathway":"GO_POSITIVE_REGULATION_OF_STEM_CELL_POPULATION_MAINTENANCE","pval":0.20634,"padj":0.79637,"ES":-0.96053,"NES":-1.36017,"nMoreExtreme":9559,"size":6,"leadingEdge":["LBH"]} {"pathway":"GO_ANTIGEN_PROCESSING_AND_PRESENTATION_ENDOGENOUS_LIPID_ANTIGEN_VIA_MHC_CLASS_IB","pval":0.37357,"padj":0.89036,"ES":-0.93343,"NES":-1.36032,"nMoreExtreme":17590,"size":5,"leadingEdge":["CD1A","CD1C","CD1B","CD1E"]} {"pathway":"GO_REGULATION_OF_MITOTIC_RECOMBINATION","pval":0.20381,"padj":0.79626,"ES":-0.96101,"NES":-1.36085,"nMoreExtreme":9442,"size":6,"leadingEdge":["BLM"]} {"pathway":"GO_RETINAL_BLOOD_VESSEL_MORPHOGENESIS","pval":0.20301,"padj":0.79569,"ES":-0.96115,"NES":-1.36104,"nMoreExtreme":9405,"size":6,"leadingEdge":["LRP5"]} {"pathway":"GO_REGULATION_OF_OXIDATIVE_PHOSPHORYLATION","pval":0.01168,"padj":0.27743,"ES":-0.98864,"NES":-1.36141,"nMoreExtreme":440,"size":21,"leadingEdge":["CDK1"]} {"pathway":"GO_DOUBLE_STRAND_BREAK_REPAIR_VIA_BREAK_INDUCED_REPLICATION","pval":0.36433,"padj":0.89036,"ES":-0.93478,"NES":-1.36229,"nMoreExtreme":17155,"size":5,"leadingEdge":["GINS2","CDC45","GINS4","CDC7"]} {"pathway":"GO_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY","pval":0.06409,"padj":0.59632,"ES":-0.78091,"NES":-1.36252,"nMoreExtreme":1727,"size":63,"leadingEdge":["LBH","DAB2","BRCA1","KANK2","DNAAF4"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_POTASSIUM_ION","pval":0.06647,"padj":0.60375,"ES":-0.9855,"NES":-1.36269,"nMoreExtreme":3033,"size":7,"leadingEdge":["CRHBP"]} {"pathway":"GO_PROLINE_TRANSPORT","pval":0.362,"padj":0.89036,"ES":-0.93517,"NES":-1.36286,"nMoreExtreme":17045,"size":5,"leadingEdge":["SLC36A1"]} {"pathway":"GO_CARDIAC_NEURAL_CREST_CELL_MIGRATION_INVOLVED_IN_OUTFLOW_TRACT_MORPHOGENESIS","pval":0.36166,"padj":0.89036,"ES":-0.93523,"NES":-1.36294,"nMoreExtreme":17029,"size":5,"leadingEdge":["BMP4"]} {"pathway":"GO_REGULATION_OF_BRANCHING_INVOLVED_IN_PROSTATE_GLAND_MORPHOGENESIS","pval":0.36166,"padj":0.89036,"ES":-0.93523,"NES":-1.36294,"nMoreExtreme":17029,"size":5,"leadingEdge":["BMP4"]} {"pathway":"GO_PULMONARY_ARTERY_MORPHOGENESIS","pval":0.36166,"padj":0.89036,"ES":-0.93523,"NES":-1.36294,"nMoreExtreme":17029,"size":5,"leadingEdge":["BMP4"]} {"pathway":"GO_COMMA_SHAPED_BODY_MORPHOGENESIS","pval":0.36166,"padj":0.89036,"ES":-0.93523,"NES":-1.36294,"nMoreExtreme":17029,"size":5,"leadingEdge":["BMP4"]} {"pathway":"GO_METANEPHRIC_COLLECTING_DUCT_DEVELOPMENT","pval":0.36166,"padj":0.89036,"ES":-0.93523,"NES":-1.36294,"nMoreExtreme":17029,"size":5,"leadingEdge":["BMP4"]} {"pathway":"GO_RESPONSE_TO_COCAINE","pval":0.09558,"padj":0.66591,"ES":-0.93296,"NES":-1.36307,"nMoreExtreme":3383,"size":28,"leadingEdge":["CCNA2","CRHBP","TIAM1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION","pval":0.12246,"padj":0.71068,"ES":-0.91935,"NES":-1.36372,"nMoreExtreme":4262,"size":30,"leadingEdge":["CDC25A","RECQL4","CDK1","DTL","CDC25C","FBXO5","ATAD5","CDC7","WNT10B"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELL_CYCLE","pval":0.00091,"padj":0.05834,"ES":-0.6283,"NES":-1.36493,"nMoreExtreme":5,"size":339,"leadingEdge":["CCNE2","E2F8","E2F1","CD28","CDC45","TAL1","CDC25A","CDC6","RECQL4","CDT1","LRP5","FEN1","CDCA5","CDK1","BRCA1","DTL","CCNA2","MAD2L1","NUSAP1","GTSE1","NDC80","AURKB","CCNF","CDC25C","PRKCA","TP73","ESPL1","SPAG5","CIT","INSR","KIF14","E2F7","UBE2C","DLGAP5","PLK4","CCNB2","CHEK1","FBXO5","FZD9","SLF1","CDK5R1","XRCC3","FAM83D","FGFR1","CCNE1","DDX11","PCNA","RACGAP1","USP2","ATAD5","CDC7","KIF20B","LSM11","TFAP4","CDK2"]} {"pathway":"GO_BRANCHIOMOTOR_NEURON_AXON_GUIDANCE","pval":0.18439,"padj":0.77988,"ES":-0.96421,"NES":-1.36539,"nMoreExtreme":8542,"size":6,"leadingEdge":["NRP1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS_IN_THE_VACUOLE","pval":0.34896,"padj":0.88316,"ES":-0.93714,"NES":-1.36573,"nMoreExtreme":16431,"size":5,"leadingEdge":["RNF128"]} {"pathway":"GO_RRNA_TRANSCRIPTION","pval":0.07145,"padj":0.62112,"ES":-0.94302,"NES":-1.36575,"nMoreExtreme":2550,"size":27,"leadingEdge":["DDX11"]} {"pathway":"GO_MITOTIC_DNA_INTEGRITY_CHECKPOINT","pval":0.03284,"padj":0.46522,"ES":-0.72087,"NES":-1.36663,"nMoreExtreme":691,"size":102,"leadingEdge":["E2F8","TOP2A","E2F1","CDC6","CLSPN","TICRR","CDK1","ORC1","GTSE1","EME1","CDC25C","E2F7","BLM"]} {"pathway":"GO_CELLULAR_COMPONENT_DISASSEMBLY_INVOLVED_IN_EXECUTION_PHASE_OF_APOPTOSIS","pval":0.08753,"padj":0.65613,"ES":-0.93542,"NES":-1.36668,"nMoreExtreme":3098,"size":28,"leadingEdge":["TOP2A","HMGB2"]} {"pathway":"GO_CRISTAE_FORMATION","pval":0.12375,"padj":0.71286,"ES":-0.91494,"NES":-1.36726,"nMoreExtreme":4273,"size":31,"leadingEdge":["UQCC3"]} {"pathway":"GO_LONG_CHAIN_FATTY_ACID_IMPORT_ACROSS_PLASMA_MEMBRANE","pval":0.34012,"padj":0.87818,"ES":-0.93843,"NES":-1.36761,"nMoreExtreme":16015,"size":5,"leadingEdge":["THBS1","IRS2"]} {"pathway":"GO_REGULATION_OF_LONG_CHAIN_FATTY_ACID_IMPORT_INTO_CELL","pval":0.34012,"padj":0.87818,"ES":-0.93843,"NES":-1.36761,"nMoreExtreme":16015,"size":5,"leadingEdge":["THBS1","IRS2"]} {"pathway":"GO_GLYCINE_METABOLIC_PROCESS","pval":0.1726,"padj":0.77332,"ES":-0.96629,"NES":-1.36833,"nMoreExtreme":7996,"size":6,"leadingEdge":["SHMT1"]} {"pathway":"GO_RETROGRADE_TRANSPORT_ENDOSOME_TO_PLASMA_MEMBRANE","pval":0.05242,"padj":0.55686,"ES":-0.95337,"NES":-1.36854,"nMoreExtreme":1887,"size":26,"leadingEdge":["LRRC7"]} {"pathway":"GO_AROMATIC_AMINO_ACID_TRANSPORT","pval":0.04592,"padj":0.53762,"ES":-0.98983,"NES":-1.36867,"nMoreExtreme":2095,"size":7,"leadingEdge":["SLC16A10","OCA2"]} {"pathway":"GO_FOLIC_ACID_TRANSPORT","pval":0.16833,"padj":0.77295,"ES":-0.96702,"NES":-1.36936,"nMoreExtreme":7798,"size":6,"leadingEdge":["SLC46A1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE","pval":0.16684,"padj":0.77278,"ES":-0.96725,"NES":-1.36968,"nMoreExtreme":7729,"size":6,"leadingEdge":["ACE"]} {"pathway":"GO_POSITIVE_REGULATION_OF_DEOXYRIBONUCLEASE_ACTIVITY","pval":0.32719,"padj":0.87108,"ES":-0.94051,"NES":-1.37064,"nMoreExtreme":15406,"size":5,"leadingEdge":["DDX11","PCNA"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CENTRIOLE_REPLICATION","pval":0.16295,"padj":0.76827,"ES":-0.96798,"NES":-1.37071,"nMoreExtreme":7549,"size":6,"leadingEdge":["PLK4"]} {"pathway":"GO_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_III","pval":0.01143,"padj":0.27533,"ES":-0.98752,"NES":-1.37129,"nMoreExtreme":427,"size":22,"leadingEdge":["BRCA1"]} {"pathway":"GO_SOMITE_SPECIFICATION","pval":0.29876,"padj":0.85717,"ES":-0.89113,"NES":-1.37166,"nMoreExtreme":14864,"size":2,"leadingEdge":["DLL1"]} {"pathway":"GO_NEURAL_PLATE_ANTERIOR_POSTERIOR_REGIONALIZATION","pval":0.31708,"padj":0.86626,"ES":-0.94203,"NES":-1.37285,"nMoreExtreme":14930,"size":5,"leadingEdge":["SSBP3","CELSR2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_GLYCOGEN_METABOLIC_PROCESS","pval":0.15363,"padj":0.75388,"ES":-0.96955,"NES":-1.37294,"nMoreExtreme":7117,"size":6,"leadingEdge":["PASK"]} {"pathway":"GO_VACUOLAR_ACIDIFICATION","pval":0.0022,"padj":0.10342,"ES":-0.99719,"NES":-1.37318,"nMoreExtreme":82,"size":21,"leadingEdge":["SLC11A1","ATP6V0D2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CORTICOSTEROID_HORMONE_SECRETION","pval":0.31398,"padj":0.86489,"ES":-0.94248,"NES":-1.3735,"nMoreExtreme":14784,"size":5,"leadingEdge":["GHRL","BMP6"]} {"pathway":"GO_MRNA_SPLICE_SITE_SELECTION","pval":0.1012,"padj":0.67298,"ES":-0.92608,"NES":-1.3737,"nMoreExtreme":3522,"size":30,"leadingEdge":["WEE2-AS1"]} {"pathway":"GO_REGULATION_OF_SYNAPSE_STRUCTURAL_PLASTICITY","pval":0.31179,"padj":0.86489,"ES":-0.94276,"NES":-1.37391,"nMoreExtreme":14681,"size":5,"leadingEdge":["CAMK1"]} {"pathway":"GO_RENAL_SODIUM_ION_TRANSPORT","pval":0.31016,"padj":0.86489,"ES":-0.94298,"NES":-1.37424,"nMoreExtreme":14604,"size":5,"leadingEdge":["SLC9A3R1"]} {"pathway":"GO_MAINTENANCE_OF_CENTROSOME_LOCATION","pval":0.14804,"padj":0.7508,"ES":-0.97051,"NES":-1.37429,"nMoreExtreme":6858,"size":6,"leadingEdge":["ASPM"]} {"pathway":"GO_ADENYLATE_CYCLASE_ACTIVATING_DOPAMINE_RECEPTOR_SIGNALING_PATHWAY","pval":0.30973,"padj":0.86489,"ES":-0.94304,"NES":-1.37432,"nMoreExtreme":14584,"size":5,"leadingEdge":["GNG2","SLC9A3R1"]} {"pathway":"GO_REGULATION_OF_SODIUM_PROTON_ANTIPORTER_ACTIVITY","pval":0.30973,"padj":0.86489,"ES":-0.94304,"NES":-1.37432,"nMoreExtreme":14584,"size":5,"leadingEdge":["TESC","SLC9A3R1"]} {"pathway":"GO_MICROTUBULE_CYTOSKELETON_ORGANIZATION","pval":0.00052,"padj":0.04002,"ES":-0.61851,"NES":-1.37458,"nMoreExtreme":1,"size":470,"leadingEdge":["TRDN","MYBL2","SPC25","PCLAF","KIF18B","CDK1","BIRC5","XRCC2","BRCA1","PRC1","KIF11","TACC2","NUF2","NUSAP1","NDC80","AURKB","STMN1","CCNF","WDR62","WEE1","SKA3","KIFC1","TTK","ESPL1","SPAG5","SKA1","AUNIP","GAS2L3","KIF2C","ASPM","CENPA","PLK4","SGO1","CHEK1","NEK2","TPX2","KIF4A","FBXO5","CDC20","KIF24","KIF20A","PLK1","CDK5R1","KIF25","DNAAF4","LMNA","CFAP44","XRCC3","TACC3","IFT172","RTTN","CENPE","CC2D2A","KAT2A","CEP72","RCC1","RACGAP1"]} {"pathway":"GO_POLYSACCHARIDE_CATABOLIC_PROCESS","pval":0.03345,"padj":0.46677,"ES":-0.96549,"NES":-1.37468,"nMoreExtreme":1213,"size":25,"leadingEdge":["G6PC"]} {"pathway":"GO_PRIMITIVE_HEMOPOIESIS","pval":0.02388,"padj":0.39206,"ES":-0.99449,"NES":-1.37512,"nMoreExtreme":1089,"size":7,"leadingEdge":["TAL1"]} {"pathway":"GO_HISTONE_H3_S10_PHOSPHORYLATION","pval":0.45289,"padj":0.90517,"ES":-0.91411,"NES":-1.37529,"nMoreExtreme":21718,"size":4,"leadingEdge":["VRK1"]} {"pathway":"GO_CHROMATIN_SILENCING_AT_TELOMERE","pval":0.02305,"padj":0.38452,"ES":-0.99472,"NES":-1.37543,"nMoreExtreme":1051,"size":7,"leadingEdge":["CDC45"]} {"pathway":"GO_RESPONSE_TO_WATER_DEPRIVATION","pval":0.14312,"padj":0.74198,"ES":-0.9714,"NES":-1.37557,"nMoreExtreme":6630,"size":6,"leadingEdge":["CD9"]} {"pathway":"GO_PURKINJE_MYOCYTE_TO_VENTRICULAR_CARDIAC_MUSCLE_CELL_SIGNALING","pval":0.45171,"padj":0.90517,"ES":-0.91439,"NES":-1.37571,"nMoreExtreme":21661,"size":4,"leadingEdge":["GJA5","SCN5A"]} {"pathway":"GO_DETOXIFICATION_OF_NITROGEN_COMPOUND","pval":0.30285,"padj":0.85939,"ES":-0.94416,"NES":-1.37596,"nMoreExtreme":14260,"size":5,"leadingEdge":["GSTM2"]} {"pathway":"GO_REGULATION_OF_GROWTH_HORMONE_SECRETION","pval":0.01932,"padj":0.35444,"ES":-0.99545,"NES":-1.37644,"nMoreExtreme":881,"size":7,"leadingEdge":["GHRL"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_FIBRINOLYSIS","pval":0.29982,"padj":0.85717,"ES":-0.94467,"NES":-1.3767,"nMoreExtreme":14117,"size":5,"leadingEdge":["THBD","THBS1"]} {"pathway":"GO_NEUTROPHIL_CLEARANCE","pval":0.29731,"padj":0.85691,"ES":-0.94506,"NES":-1.37727,"nMoreExtreme":13999,"size":5,"leadingEdge":["MERTK","CCR2"]} {"pathway":"GO_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_I","pval":0.06474,"padj":0.60006,"ES":-0.94302,"NES":-1.37777,"nMoreExtreme":2291,"size":28,"leadingEdge":["DDX11"]} {"pathway":"GO_REGULATION_OF_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY","pval":0.00665,"padj":0.21408,"ES":-0.9923,"NES":-1.37793,"nMoreExtreme":248,"size":22,"leadingEdge":["DAB2"]} {"pathway":"GO_LUNG_ASSOCIATED_MESENCHYME_DEVELOPMENT","pval":0.28797,"padj":0.84886,"ES":-0.94652,"NES":-1.3794,"nMoreExtreme":13559,"size":5,"leadingEdge":["FGFR1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY","pval":0.04296,"padj":0.52235,"ES":-0.75503,"NES":-1.3795,"nMoreExtreme":1031,"size":81,"leadingEdge":["DAB2","TTK","TGFBR3","GDF7","CDKN2B","THBS1","BMP6","BMP8A","BMP4","ENG","BMP2"]} {"pathway":"GO_CARBOHYDRATE_MEDIATED_SIGNALING","pval":0.00892,"padj":0.24715,"ES":-0.99787,"NES":-1.37978,"nMoreExtreme":406,"size":7,"leadingEdge":["COLEC12"]} {"pathway":"GO_POSTSYNAPTIC_ACTIN_CYTOSKELETON_ORGANIZATION","pval":0.00642,"padj":0.20961,"ES":-0.99848,"NES":-1.38063,"nMoreExtreme":292,"size":7,"leadingEdge":["INA"]} {"pathway":"GO_NON_CANONICAL_WNT_SIGNALING_PATHWAY_VIA_MAPK_CASCADE","pval":0.28072,"padj":0.84299,"ES":-0.94759,"NES":-1.38095,"nMoreExtreme":13218,"size":5,"leadingEdge":["FZD7"]} {"pathway":"GO_KETONE_BIOSYNTHETIC_PROCESS","pval":0.09856,"padj":0.66685,"ES":-0.92411,"NES":-1.38096,"nMoreExtreme":3403,"size":31,"leadingEdge":["CYP19A1","BMP6","BMP2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELL_FATE_SPECIFICATION","pval":0.28038,"padj":0.84253,"ES":-0.94764,"NES":-1.38103,"nMoreExtreme":13202,"size":5,"leadingEdge":["SOX17","FZD7"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR_VIA_NONHOMOLOGOUS_END_JOINING","pval":0.12095,"padj":0.7062,"ES":-0.97539,"NES":-1.38122,"nMoreExtreme":5603,"size":6,"leadingEdge":["AUNIP"]} {"pathway":"GO_REGULATION_OF_DNA_DIRECTED_DNA_POLYMERASE_ACTIVITY","pval":0.12052,"padj":0.7062,"ES":-0.97551,"NES":-1.38137,"nMoreExtreme":5583,"size":6,"leadingEdge":["DSCC1","CHTF18","RFC3","RFC5","RFC4"]} {"pathway":"GO_LEUKOTRIENE_BIOSYNTHETIC_PROCESS","pval":0.00379,"padj":0.14958,"ES":-0.99916,"NES":-1.38156,"nMoreExtreme":172,"size":7,"leadingEdge":["LTC4S"]} {"pathway":"GO_XENOBIOTIC_TRANSPORT","pval":0.00366,"padj":0.14676,"ES":-0.99921,"NES":-1.38164,"nMoreExtreme":166,"size":7,"leadingEdge":["ABCG2"]} {"pathway":"GO_MICROTUBULE_ORGANIZING_CENTER_ORGANIZATION","pval":0.02044,"padj":0.36159,"ES":-0.70533,"NES":-1.3817,"nMoreExtreme":375,"size":127,"leadingEdge":["PCLAF","CDK1","XRCC2","BRCA1","KIF11","CCNF","WDR62","PLK4","SGO1","CHEK1","NEK2","PLK1","KIF25","XRCC3","RTTN","KAT2A","CEP72","STIL"]} {"pathway":"GO_MITOCHONDRIAL_PROTEIN_CATABOLIC_PROCESS","pval":0.27713,"padj":0.84047,"ES":-0.94815,"NES":-1.38177,"nMoreExtreme":13049,"size":5,"leadingEdge":["SPATA18"]} {"pathway":"GO_EXOCRINE_PANCREAS_DEVELOPMENT","pval":0.27635,"padj":0.83968,"ES":-0.94832,"NES":-1.38202,"nMoreExtreme":13012,"size":5,"leadingEdge":["INSR","WLS"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION","pval":0.0368,"padj":0.49381,"ES":-0.74758,"NES":-1.38204,"nMoreExtreme":851,"size":87,"leadingEdge":["CDC45","CDC25A","CDC6","RECQL4","CDT1","CDCA5","CDK1","DTL","CDC25C","ESPL1","UBE2C","DLGAP5","FBXO5","FAM83D","CCNE1","ATAD5","CDC7","LSM11"]} {"pathway":"GO_CRANIAL_GANGLION_DEVELOPMENT","pval":0.11759,"padj":0.70191,"ES":-0.97605,"NES":-1.38215,"nMoreExtreme":5447,"size":6,"leadingEdge":["NRP1"]} {"pathway":"GO_SPHINGOSINE_1_PHOSPHATE_RECEPTOR_SIGNALING_PATHWAY","pval":0.00074,"padj":0.05258,"ES":-0.99983,"NES":-1.3825,"nMoreExtreme":33,"size":7,"leadingEdge":["S1PR1"]} {"pathway":"GO_SISTER_CHROMATID_COHESION","pval":0.06749,"padj":0.60666,"ES":-0.82226,"NES":-1.38411,"nMoreExtreme":1956,"size":53,"leadingEdge":["MEIKIN","DSCC1","ESCO2","FEN1","CDCA5","BUB1B","HASPIN","ESPL1","SGO1","BUB1","CDC20","PLK1","SLF1","DDX11","KIF22"]} {"pathway":"GO_PURINE_DEOXYRIBONUCLEOSIDE_TRIPHOSPHATE_CATABOLIC_PROCESS","pval":0.26543,"padj":0.83566,"ES":-0.95,"NES":-1.38447,"nMoreExtreme":12498,"size":5,"leadingEdge":["NUDT1"]} {"pathway":"GO_DNA_PROTECTION","pval":0.26543,"padj":0.83566,"ES":-0.95,"NES":-1.38447,"nMoreExtreme":12498,"size":5,"leadingEdge":["NUDT1"]} {"pathway":"GO_TERMINAL_BUTTON_ORGANIZATION","pval":0.41707,"padj":0.89503,"ES":-0.92068,"NES":-1.38517,"nMoreExtreme":20000,"size":4,"leadingEdge":["NLGN2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SYNAPTIC_VESICLE_CLUSTERING","pval":0.41707,"padj":0.89503,"ES":-0.92068,"NES":-1.38517,"nMoreExtreme":20000,"size":4,"leadingEdge":["NLGN2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_UBIQUITIN_PROTEIN_TRANSFERASE_ACTIVITY","pval":0.07535,"padj":0.63068,"ES":-0.9344,"NES":-1.38604,"nMoreExtreme":2622,"size":30,"leadingEdge":["UBE2C","CDC20","PLK1"]} {"pathway":"GO_CELL_FATE_SPECIFICATION_INVOLVED_IN_PATTERN_SPECIFICATION","pval":0.41077,"padj":0.89503,"ES":-0.92169,"NES":-1.3867,"nMoreExtreme":19698,"size":4,"leadingEdge":["NKX6-2"]} {"pathway":"GO_LIPOXIN_BIOSYNTHETIC_PROCESS","pval":0.25439,"padj":0.82744,"ES":-0.9518,"NES":-1.38709,"nMoreExtreme":11978,"size":5,"leadingEdge":["LTC4S","HPGD","ALOX15"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER","pval":0.40915,"padj":0.89503,"ES":-0.92198,"NES":-1.38712,"nMoreExtreme":19620,"size":4,"leadingEdge":["CTNNBIP1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION","pval":0.40915,"padj":0.89503,"ES":-0.92198,"NES":-1.38712,"nMoreExtreme":19620,"size":4,"leadingEdge":["CTNNBIP1"]} {"pathway":"GO_EYE_PIGMENTATION","pval":0.09771,"padj":0.66591,"ES":-0.97991,"NES":-1.38761,"nMoreExtreme":4526,"size":6,"leadingEdge":["OCA2"]} {"pathway":"GO_DOUBLE_STRAND_BREAK_REPAIR","pval":0.00608,"padj":0.20304,"ES":-0.66664,"NES":-1.38827,"nMoreExtreme":72,"size":213,"leadingEdge":["GINS2","CDC45","RAD54L","RECQL4","ESCO2","DMC1","FEN1","CDCA5","XRCC2","BRCA1","EME1","TONSL","POLQ","MCM8","AUNIP","RAD51","DNA2","FANCB","MMS22L","FOXM1","PARP2","POLA1","CHEK1","TRIP13","BLM","SLF1","RAD51AP1","XRCC3","DDX11","GINS4","USP51"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CHROMATIN_ORGANIZATION","pval":0.07756,"padj":0.63581,"ES":-0.85992,"NES":-1.38955,"nMoreExtreme":2389,"size":44,"leadingEdge":["BRCA1","ATAD2","SKI","JARID2"]} {"pathway":"GO_ANDROGEN_CATABOLIC_PROCESS","pval":0.24025,"padj":0.82313,"ES":-0.95394,"NES":-1.3902,"nMoreExtreme":11312,"size":5,"leadingEdge":["CYP19A1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_GLUCOCORTICOID_METABOLIC_PROCESS","pval":0.39659,"padj":0.89503,"ES":-0.92411,"NES":-1.39033,"nMoreExtreme":19018,"size":4,"leadingEdge":["BMP2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION","pval":0.08623,"padj":0.65271,"ES":-0.98202,"NES":-1.3906,"nMoreExtreme":3994,"size":6,"leadingEdge":["DLL1"]} {"pathway":"GO_REGULATION_OF_SOMITOGENESIS","pval":0.08623,"padj":0.65271,"ES":-0.98202,"NES":-1.3906,"nMoreExtreme":3994,"size":6,"leadingEdge":["DLL1"]} {"pathway":"GO_CORNIFICATION","pval":0.07852,"padj":0.63581,"ES":-0.93069,"NES":-1.3908,"nMoreExtreme":2711,"size":31,"leadingEdge":["KRT80","PCSK6","KRT10","KRT7"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PINOCYTOSIS","pval":0.08547,"padj":0.65271,"ES":-0.98219,"NES":-1.39084,"nMoreExtreme":3959,"size":6,"leadingEdge":["APPL2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ASTROCYTE_ACTIVATION","pval":0.23744,"padj":0.82177,"ES":-0.95438,"NES":-1.39086,"nMoreExtreme":11180,"size":5,"leadingEdge":["TREM2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_AMYLOID_BETA_CLEARANCE","pval":0.23744,"padj":0.82177,"ES":-0.95438,"NES":-1.39086,"nMoreExtreme":11180,"size":5,"leadingEdge":["TREM2"]} {"pathway":"GO_NUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS","pval":0.08791,"padj":0.65627,"ES":-0.88898,"NES":-1.39131,"nMoreExtreme":2846,"size":38,"leadingEdge":["TYMS","TK1","SHMT1","DUT"]} {"pathway":"GO_ENDOCARDIAL_CELL_DIFFERENTIATION","pval":0.08372,"padj":0.64968,"ES":-0.98253,"NES":-1.39132,"nMoreExtreme":3878,"size":6,"leadingEdge":["SOX17"]} {"pathway":"GO_ANAGEN","pval":0.39207,"padj":0.89503,"ES":-0.92484,"NES":-1.39143,"nMoreExtreme":18801,"size":4,"leadingEdge":["WNT10B"]} {"pathway":"GO_MECHANORECEPTOR_DIFFERENTIATION","pval":0.07964,"padj":0.63757,"ES":-0.86939,"NES":-1.39176,"nMoreExtreme":2502,"size":42,"leadingEdge":["DLL1","SLC4A7","MYO7A","FGFR1","SLC9A3R1","BMP4"]} {"pathway":"GO_CELL_RECOGNITION","pval":0.02899,"padj":0.42649,"ES":-0.7406,"NES":-1.39193,"nMoreExtreme":636,"size":96,"leadingEdge":["PCDH12","COLEC12","EPHB3","NRP1","TNFRSF21","VCAN","FCN1","CD9","CDK5R1"]} {"pathway":"GO_NEURAL_TUBE_FORMATION","pval":0.02975,"padj":0.43243,"ES":-0.74235,"NES":-1.39268,"nMoreExtreme":656,"size":95,"leadingEdge":["IFT122","CELSR1","FZD3","GDF7","PRKACB","IFT172","CC2D2A","SEMA4C","KAT2A","SKI","STIL","BMP4","KIF20B","SHROOM3"]} {"pathway":"GO_MAINTENANCE_OF_DNA_METHYLATION","pval":0.07584,"padj":0.63269,"ES":-0.98399,"NES":-1.39339,"nMoreExtreme":3513,"size":6,"leadingEdge":["HELLS","UHRF1"]} {"pathway":"GO_MITOTIC_CELL_CYCLE","pval":0.00149,"padj":0.08339,"ES":-0.60608,"NES":-1.39409,"nMoreExtreme":0,"size":910,"leadingEdge":["CCNE2","IQGAP3","E2F8","TOP2A","E2F1","CD28","MYBL2","MCM10","SPC25","RRM2","CDKN2C","TYMS","CDC45","TAL1","CDC25A","CDC6","CLSPN","TICRR","MCM6","RECQL4","MCM7","DSCC1","MCM4","KIF18B","CDT1","LRP5","MCM2","KIF15","NCAPG","CDCA5","ZWINT","PKMYT1","CDK1","BIRC5","XRCC2","ANLN","DHFR","BRCA1","DTL","PRC1","MKI67","CCNA2","KIF11","MAD2L1","ORC1","TACC2","NUF2","POLE2","NUSAP1","GTSE1","NDC80","AURKB","MCM5","NCAPH","STMN1","CCNF","BUB1B","CENPF","WDR62","EME1","WEE1","GINS1","SKA3","MYBL1","KIFC1","HASPIN","CDC25C","KANK2","PRKCA","TTK","TP73","MCM8","ESPL1","SPAG5","SKA1","CIT","INSR","RAD51","KIF14","DNA2","ORC6","FZD3","E2F7","JADE1","FOXM1","WDHD1","KIF2C","UBE2C","CTDSPL","POLA1","CENPA","DLGAP5","PLK4","SGO1","CCNB2","CHEK1","NEK2","TPX2","KIF4A","FBXO5","CDCA8","BCL2","BUB1","CDC20","NCAPD3","POLE","PBK","RRM1","TRIP13","KIF20A","BLM","PLK1","SLF1","SMC4","MYB","CEP55","CDKN2B","KIF25","SMC2","MCM3","LMNA","XRCC3","TACC3","DSN1","FGFR1","NCAPD2","CENPE","CDKN3","CCNE1","NES","SLC9A3R1","HMMR","CEP72","PCNA","RCC1","RACGAP1","DONSON","USP2","TPD52L1","STIL","NCAPH2","BMP4","ATAD5","CDC7","KIF22","RBL1"]} {"pathway":"GO_REGULATION_OF_INOSITOL_TRISPHOSPHATE_BIOSYNTHETIC_PROCESS","pval":0.22251,"padj":0.80586,"ES":-0.95686,"NES":-1.39446,"nMoreExtreme":10477,"size":5,"leadingEdge":["HRH1"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_HISTAMINE","pval":0.22251,"padj":0.80586,"ES":-0.95686,"NES":-1.39446,"nMoreExtreme":10477,"size":5,"leadingEdge":["HRH1"]} {"pathway":"GO_REGULATION_OF_CELL_CYCLE_CHECKPOINT","pval":0.07134,"padj":0.62112,"ES":-0.93328,"NES":-1.39467,"nMoreExtreme":2463,"size":31,"leadingEdge":["CDT1","WDR76","MAD2L1","NDC80","XRCC3"]} {"pathway":"GO_MRNA_CIS_SPLICING_VIA_SPLICEOSOME","pval":0.08409,"padj":0.65144,"ES":-0.92607,"NES":-1.39469,"nMoreExtreme":2878,"size":32,"leadingEdge":["WEE2-AS1"]} {"pathway":"GO_REGULATION_OF_MODIFICATION_OF_POSTSYNAPTIC_STRUCTURE","pval":0.21859,"padj":0.80167,"ES":-0.95747,"NES":-1.39536,"nMoreExtreme":10292,"size":5,"leadingEdge":["CTTNBP2","TIAM1"]} {"pathway":"GO_BEHAVIORAL_RESPONSE_TO_ETHANOL","pval":0.06831,"padj":0.61155,"ES":-0.98551,"NES":-1.39554,"nMoreExtreme":3164,"size":6,"leadingEdge":["CRHBP"]} {"pathway":"GO_CARDIAC_MUSCLE_CELL_CARDIAC_MUSCLE_CELL_ADHESION","pval":0.06648,"padj":0.60375,"ES":-0.98584,"NES":-1.39601,"nMoreExtreme":3079,"size":6,"leadingEdge":["CXADR"]} {"pathway":"GO_MIDBRAIN_HINDBRAIN_BOUNDARY_DEVELOPMENT","pval":0.21553,"padj":0.80152,"ES":-0.95814,"NES":-1.39633,"nMoreExtreme":10148,"size":5,"leadingEdge":["SSBP3"]} {"pathway":"GO_PROTEIN_RETENTION_IN_GOLGI_APPARATUS","pval":0.21379,"padj":0.7999,"ES":-0.95837,"NES":-1.39667,"nMoreExtreme":10066,"size":5,"leadingEdge":["SORL1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_LOW_DENSITY_LIPOPROTEIN_PARTICLE_CLEARANCE","pval":0.36894,"padj":0.89036,"ES":-0.92872,"NES":-1.39726,"nMoreExtreme":17692,"size":4,"leadingEdge":["IL19"]} {"pathway":"GO_CORONARY_VASCULATURE_DEVELOPMENT","pval":0.07869,"padj":0.63581,"ES":-0.87721,"NES":-1.39738,"nMoreExtreme":2490,"size":41,"leadingEdge":["NRP1","SGCD","TGFBR3","BMP4","PLXND1"]} {"pathway":"GO_GOLGI_DISASSEMBLY","pval":0.06104,"padj":0.58982,"ES":-0.98693,"NES":-1.39756,"nMoreExtreme":2827,"size":6,"leadingEdge":["CDK1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_HYDROGEN_PEROXIDE_MEDIATED_PROGRAMMED_CELL_DEATH","pval":0.36713,"padj":0.89036,"ES":-0.929,"NES":-1.39768,"nMoreExtreme":17605,"size":4,"leadingEdge":["FOXO3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SMAD_PROTEIN_COMPLEX_ASSEMBLY","pval":0.20926,"padj":0.79637,"ES":-0.95922,"NES":-1.3979,"nMoreExtreme":9853,"size":5,"leadingEdge":["LDLRAD4"]} {"pathway":"GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_NOREPINEPHRINE_EPINEPHRINE","pval":0.20863,"padj":0.79637,"ES":-0.95933,"NES":-1.39806,"nMoreExtreme":9823,"size":5,"leadingEdge":["ADRB1"]} {"pathway":"GO_LACTATE_TRANSPORT","pval":0.36308,"padj":0.89036,"ES":-0.92973,"NES":-1.39878,"nMoreExtreme":17411,"size":4,"leadingEdge":["SLC16A7"]} {"pathway":"GO_TRNA_TRANSPORT","pval":0.09243,"padj":0.66428,"ES":-0.91672,"NES":-1.39891,"nMoreExtreme":3106,"size":34,"leadingEdge":["NDC1"]} {"pathway":"GO_REGULATION_OF_T_HELPER_1_CELL_CYTOKINE_PRODUCTION","pval":0.3626,"padj":0.89036,"ES":-0.92984,"NES":-1.39895,"nMoreExtreme":17388,"size":4,"leadingEdge":["IL18"]} {"pathway":"GO_MEIOTIC_SISTER_CHROMATID_COHESION_CENTROMERIC","pval":0.20525,"padj":0.79637,"ES":-0.95998,"NES":-1.39901,"nMoreExtreme":9664,"size":5,"leadingEdge":["MEIKIN","BUB1B","BUB1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_HEXOKINASE_ACTIVITY","pval":0.36158,"padj":0.89036,"ES":-0.93001,"NES":-1.3992,"nMoreExtreme":17339,"size":4,"leadingEdge":["PRKN"]} {"pathway":"GO_MEIOSIS_I_CELL_CYCLE_PROCESS","pval":0.03771,"padj":0.49791,"ES":-0.76927,"NES":-1.39923,"nMoreExtreme":915,"size":79,"leadingEdge":["CCNE2","TOP2A","MEIKIN","CDC25A","DMC1","EME1","MYBL1","MND1","CDC25C","ESPL1","RAD51","PSMC3IP","FBXO5","TRIP13","BLM","PLK1","CENPS","CCNE1"]} {"pathway":"GO_ELASTIN_METABOLIC_PROCESS","pval":0.05486,"padj":0.56331,"ES":-0.98815,"NES":-1.39927,"nMoreExtreme":2541,"size":6,"leadingEdge":["HBEGF"]} {"pathway":"GO_DNA_REPLICATION_INITIATION","pval":0.09187,"padj":0.66374,"ES":-0.91077,"NES":-1.39938,"nMoreExtreme":3063,"size":35,"leadingEdge":["CCNE2","MCM10","CDC45","CDC6","TICRR","MCM6","MCM7","MCM4","CDT1","MCM2","ORC1","POLE2","MCM5","ORC6","POLA1","POLE","MCM3","CCNE1"]} {"pathway":"GO_DICHOTOMOUS_SUBDIVISION_OF_TERMINAL_UNITS_INVOLVED_IN_SALIVARY_GLAND_BRANCHING","pval":0.20287,"padj":0.79569,"ES":-0.96036,"NES":-1.39957,"nMoreExtreme":9552,"size":5,"leadingEdge":["NRP1"]} {"pathway":"GO_CHOLINE_CATABOLIC_PROCESS","pval":0.3595,"padj":0.89036,"ES":-0.93034,"NES":-1.39971,"nMoreExtreme":17239,"size":4,"leadingEdge":["ALDH7A1"]} {"pathway":"GO_AXONOGENESIS_INVOLVED_IN_INNERVATION","pval":0.20149,"padj":0.79396,"ES":-0.9606,"NES":-1.39992,"nMoreExtreme":9487,"size":5,"leadingEdge":["NRP1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_OXIDATIVE_PHOSPHORYLATION","pval":0.05217,"padj":0.55686,"ES":-0.98865,"NES":-1.39999,"nMoreExtreme":2416,"size":6,"leadingEdge":["CDK1"]} {"pathway":"GO_REGULATION_OF_MITOCHONDRIAL_ATP_SYNTHESIS_COUPLED_ELECTRON_TRANSPORT","pval":0.05217,"padj":0.55686,"ES":-0.98865,"NES":-1.39999,"nMoreExtreme":2416,"size":6,"leadingEdge":["CDK1"]} {"pathway":"GO_STEM_CELL_DIVISION","pval":0.09121,"padj":0.66096,"ES":-0.91747,"NES":-1.40005,"nMoreExtreme":3065,"size":34,"leadingEdge":["LBH","SOX17","ASPM","FZD7","FGFR1"]} {"pathway":"GO_ENERGY_DERIVATION_BY_OXIDATION_OF_ORGANIC_COMPOUNDS","pval":0.00402,"padj":0.15358,"ES":-0.66464,"NES":-1.40034,"nMoreExtreme":42,"size":237,"leadingEdge":["PCDH12","PID1","G6PC","CDK1","KL","INSR","KHK","PASK","CAT","IRS2","PPP1R3G"]} {"pathway":"GO_RESPONSE_TO_CAMPTOTHECIN","pval":0.19865,"padj":0.79183,"ES":-0.96107,"NES":-1.4006,"nMoreExtreme":9353,"size":5,"leadingEdge":["RAD51","BLM"]} {"pathway":"GO_COHESIN_LOADING","pval":0.04999,"padj":0.55243,"ES":-0.9891,"NES":-1.40063,"nMoreExtreme":2315,"size":6,"leadingEdge":["CDCA5"]} {"pathway":"GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CHROMATIN","pval":0.04999,"padj":0.55243,"ES":-0.9891,"NES":-1.40063,"nMoreExtreme":2315,"size":6,"leadingEdge":["CDCA5"]} {"pathway":"GO_MITOTIC_CYTOKINESIS","pval":0.04808,"padj":0.5476,"ES":-0.79739,"NES":-1.40106,"nMoreExtreme":1279,"size":65,"leadingEdge":["CDT1","ANLN","NUSAP1","STMN1","ESPL1","CIT","CENPA","KIF4A","KIF20A","PLK1","CEP55","RACGAP1","KIF20B","EFHC1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS","pval":0.04858,"padj":0.5476,"ES":-0.98942,"NES":-1.40108,"nMoreExtreme":2250,"size":6,"leadingEdge":["GHRL"]} {"pathway":"GO_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY","pval":0.02842,"padj":0.42056,"ES":-0.74862,"NES":-1.40129,"nMoreExtreme":629,"size":94,"leadingEdge":["CCNE2","CDKN2C","CDC25A","CDC6","PKMYT1","CCNA2","CCNF","CDC25C","CCNB2","BLM","PLK1","CDK5R1","CDKN2B","CDKN3","CCNE1"]} {"pathway":"GO_REGULATION_OF_MITOTIC_CYTOKINESIS","pval":0.35295,"padj":0.888,"ES":-0.93147,"NES":-1.4014,"nMoreExtreme":16925,"size":4,"leadingEdge":["KIF20B"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY","pval":0.04448,"padj":0.5276,"ES":-0.99039,"NES":-1.40246,"nMoreExtreme":2060,"size":6,"leadingEdge":["MMP9"]} {"pathway":"GO_PRESYNAPTIC_DENSE_CORE_VESICLE_EXOCYTOSIS","pval":0.04412,"padj":0.5266,"ES":-0.99051,"NES":-1.40262,"nMoreExtreme":2043,"size":6,"leadingEdge":["SYT6"]} {"pathway":"GO_HINDBRAIN_MORPHOGENESIS","pval":0.07874,"padj":0.63581,"ES":-0.92542,"NES":-1.40279,"nMoreExtreme":2668,"size":33,"leadingEdge":["DAB1","DLL1","KIF14"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_CHECKPOINT","pval":0.04159,"padj":0.51963,"ES":-0.99101,"NES":-1.40333,"nMoreExtreme":1926,"size":6,"leadingEdge":["CDT1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE_MEDIATED_BY_CIRCULATING_IMMUNOGLOBULIN","pval":0.34569,"padj":0.88254,"ES":-0.93282,"NES":-1.40343,"nMoreExtreme":16577,"size":4,"leadingEdge":["CR1"]} {"pathway":"GO_MISMATCH_REPAIR","pval":0.07738,"padj":0.63581,"ES":-0.92596,"NES":-1.4036,"nMoreExtreme":2622,"size":33,"leadingEdge":["EXO1","TP73","PCNA","MSH2","POLD2","LIG1"]} {"pathway":"GO_TRIGEMINAL_NERVE_MORPHOGENESIS","pval":0.18083,"padj":0.77555,"ES":-0.96421,"NES":-1.40518,"nMoreExtreme":8514,"size":5,"leadingEdge":["NRP1"]} {"pathway":"GO_NEURAL_CREST_CELL_MIGRATION_INVOLVED_IN_AUTONOMIC_NERVOUS_SYSTEM_DEVELOPMENT","pval":0.18083,"padj":0.77555,"ES":-0.96421,"NES":-1.40518,"nMoreExtreme":8514,"size":5,"leadingEdge":["NRP1"]} {"pathway":"GO_SMOOTHENED_SIGNALING_PATHWAY_INVOLVED_IN_VENTRAL_SPINAL_CORD_PATTERNING","pval":0.03445,"padj":0.47454,"ES":-0.99247,"NES":-1.4054,"nMoreExtreme":1595,"size":6,"leadingEdge":["IFT122"]} {"pathway":"GO_POSITIVE_REGULATION_OF_GLYCOGEN_STARCH_SYNTHASE_ACTIVITY","pval":0.33291,"padj":0.87469,"ES":-0.93495,"NES":-1.40664,"nMoreExtreme":15964,"size":4,"leadingEdge":["PPP1R3G"]} {"pathway":"GO_L_ALANINE_TRANSPORT","pval":0.33164,"padj":0.87332,"ES":-0.93518,"NES":-1.40698,"nMoreExtreme":15903,"size":4,"leadingEdge":["SLC36A1"]} {"pathway":"GO_IMMATURE_T_CELL_PROLIFERATION_IN_THYMUS","pval":0.33143,"padj":0.87332,"ES":-0.93523,"NES":-1.40706,"nMoreExtreme":15893,"size":4,"leadingEdge":["BMP4"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_IMMATURE_T_CELL_PROLIFERATION","pval":0.33143,"padj":0.87332,"ES":-0.93523,"NES":-1.40706,"nMoreExtreme":15893,"size":4,"leadingEdge":["BMP4"]} {"pathway":"GO_EPITHELIAL_MESENCHYMAL_CELL_SIGNALING","pval":0.33143,"padj":0.87332,"ES":-0.93523,"NES":-1.40706,"nMoreExtreme":15893,"size":4,"leadingEdge":["BMP4"]} {"pathway":"GO_REGULATION_OF_PROSTATIC_BUD_FORMATION","pval":0.33143,"padj":0.87332,"ES":-0.93523,"NES":-1.40706,"nMoreExtreme":15893,"size":4,"leadingEdge":["BMP4"]} {"pathway":"GO_POSITIVE_REGULATION_OF_NEURON_MATURATION","pval":0.17097,"padj":0.77295,"ES":-0.9659,"NES":-1.40764,"nMoreExtreme":8050,"size":5,"leadingEdge":["BCL2"]} {"pathway":"GO_MEIOTIC_CHROMOSOME_SEGREGATION","pval":0.04935,"padj":0.55061,"ES":-0.81465,"NES":-1.40776,"nMoreExtreme":1357,"size":60,"leadingEdge":["CCNE2","TOP2A","MEIKIN","DMC1","NUF2","NCAPH","BUB1B","EME1","TTK","ESPL1","SGO1","BUB1","TRIP13","BLM","PLK1","SMC4","SMC2","CENPS","CCNE1"]} {"pathway":"GO_L_SERINE_METABOLIC_PROCESS","pval":0.16887,"padj":0.77295,"ES":-0.96629,"NES":-1.40821,"nMoreExtreme":7951,"size":5,"leadingEdge":["SHMT1"]} {"pathway":"GO_SPINDLE_ASSEMBLY_INVOLVED_IN_MEIOSIS","pval":0.16823,"padj":0.77295,"ES":-0.96641,"NES":-1.40838,"nMoreExtreme":7921,"size":5,"leadingEdge":["ASPM","FBXO5"]} {"pathway":"GO_PYRIMIDINE_NUCLEOTIDE_METABOLIC_PROCESS","pval":0.02329,"padj":0.38612,"ES":-0.99478,"NES":-1.40866,"nMoreExtreme":1078,"size":6,"leadingEdge":["TYMS"]} {"pathway":"GO_RESPONSE_TO_SORBITOL","pval":0.16486,"padj":0.76986,"ES":-0.96697,"NES":-1.4092,"nMoreExtreme":7762,"size":5,"leadingEdge":["CDT1","MAP2K6","MAPK13"]} {"pathway":"GO_FOLATE_TRANSMEMBRANE_TRANSPORT","pval":0.16462,"padj":0.76986,"ES":-0.96702,"NES":-1.40928,"nMoreExtreme":7751,"size":5,"leadingEdge":["SLC46A1"]} {"pathway":"GO_REGULATION_OF_PEPTIDYL_TYROSINE_AUTOPHOSPHORYLATION","pval":0.16305,"padj":0.76827,"ES":-0.96725,"NES":-1.40961,"nMoreExtreme":7677,"size":5,"leadingEdge":["ACE"]} {"pathway":"GO_GLUCOCORTICOID_SECRETION","pval":0.02003,"padj":0.36056,"ES":-0.99545,"NES":-1.40962,"nMoreExtreme":927,"size":6,"leadingEdge":["GHRL"]} {"pathway":"GO_ANTERIOR_HEAD_DEVELOPMENT","pval":0.0193,"padj":0.35444,"ES":-0.99562,"NES":-1.40985,"nMoreExtreme":893,"size":6,"leadingEdge":["SSBP3"]} {"pathway":"GO_MULTI_CILIATED_EPITHELIAL_CELL_DIFFERENTIATION","pval":0.15917,"padj":0.76421,"ES":-0.96798,"NES":-1.41067,"nMoreExtreme":7494,"size":5,"leadingEdge":["PLK4"]} {"pathway":"GO_HISTONE_H3_K9_DIMETHYLATION","pval":0.15825,"padj":0.76311,"ES":-0.96809,"NES":-1.41083,"nMoreExtreme":7451,"size":5,"leadingEdge":["SUV39H2"]} {"pathway":"GO_OXALATE_TRANSPORT","pval":0.15537,"padj":0.75836,"ES":-0.96865,"NES":-1.41165,"nMoreExtreme":7315,"size":5,"leadingEdge":["SLC26A9"]} {"pathway":"GO_MANGANESE_ION_TRANSPORT","pval":0.01211,"padj":0.28135,"ES":-0.99725,"NES":-1.41216,"nMoreExtreme":560,"size":6,"leadingEdge":["SLC11A1"]} {"pathway":"GO_RESPONSE_TO_SELENIUM_ION","pval":0.01187,"padj":0.27955,"ES":-0.9973,"NES":-1.41224,"nMoreExtreme":549,"size":6,"leadingEdge":["SELENOP"]} {"pathway":"GO_REGULATION_OF_SYNAPTIC_VESICLE_FUSION_TO_PRESYNAPTIC_ACTIVE_ZONE_MEMBRANE","pval":0.01161,"padj":0.27743,"ES":-0.99736,"NES":-1.41232,"nMoreExtreme":537,"size":6,"leadingEdge":["SYT1"]} {"pathway":"GO_EMBRYONIC_CLEAVAGE","pval":0.01081,"padj":0.26818,"ES":-0.99753,"NES":-1.41256,"nMoreExtreme":500,"size":6,"leadingEdge":["TOP2A"]} {"pathway":"GO_REGULATION_OF_NEUTROPHIL_MEDIATED_CYTOTOXICITY","pval":0.38305,"padj":0.89036,"ES":-0.91541,"NES":-1.41275,"nMoreExtreme":18723,"size":3,"leadingEdge":["DNASE1"]} {"pathway":"GO_CHROMATIN_REMODELING_AT_CENTROMERE","pval":0.0524,"padj":0.55686,"ES":-0.93822,"NES":-1.41299,"nMoreExtreme":1793,"size":32,"leadingEdge":["HELLS","CENPM","OIP5","CENPU","CENPK","HJURP","CENPI","KNL1","CENPA","CENPP","CENPH","CENPS","CENPN","CENPQ"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CHROMOSOME_SEGREGATION","pval":0.07054,"padj":0.62014,"ES":-0.8871,"NES":-1.41314,"nMoreExtreme":2232,"size":41,"leadingEdge":["CDT1","MAD2L1","NDC80","AURKB","BUB1B","CENPF","TTK","ESPL1","FBXO5","BUB1","CDC20","TRIP13","PLK1","XRCC3"]} {"pathway":"GO_HISTONE_H3_K4_DEMETHYLATION_TRIMETHYL_H3_K4_SPECIFIC","pval":0.30757,"padj":0.86308,"ES":-0.93928,"NES":-1.41315,"nMoreExtreme":14749,"size":4,"leadingEdge":["JARID2"]} {"pathway":"GO_MICROTUBULE_ORGANIZING_CENTER_LOCALIZATION","pval":0.02031,"padj":0.36159,"ES":-0.96743,"NES":-1.41344,"nMoreExtreme":718,"size":28,"leadingEdge":["PLXNA2","ASPM","FHOD1"]} {"pathway":"GO_POINTED_END_ACTIN_FILAMENT_CAPPING","pval":0.3062,"padj":0.86288,"ES":-0.9395,"NES":-1.41349,"nMoreExtreme":14683,"size":4,"leadingEdge":["LMOD1"]} {"pathway":"GO_DUMP_BIOSYNTHETIC_PROCESS","pval":0.30505,"padj":0.86182,"ES":-0.93967,"NES":-1.41374,"nMoreExtreme":14628,"size":4,"leadingEdge":["DUT"]} {"pathway":"GO_NEUROFILAMENT_CYTOSKELETON_ORGANIZATION","pval":0.00686,"padj":0.21717,"ES":-0.99848,"NES":-1.41391,"nMoreExtreme":317,"size":6,"leadingEdge":["INA"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MONOCYTE_CHEMOTACTIC_PROTEIN_1_PRODUCTION","pval":0.30392,"padj":0.86102,"ES":-0.93989,"NES":-1.41408,"nMoreExtreme":14574,"size":4,"leadingEdge":["C1QTNF3"]} {"pathway":"GO_REGULATION_OF_VERY_LOW_DENSITY_LIPOPROTEIN_PARTICLE_CLEARANCE","pval":0.37859,"padj":0.89036,"ES":-0.91636,"NES":-1.41423,"nMoreExtreme":18505,"size":3,"leadingEdge":["APOC1"]} {"pathway":"GO_CENTRAL_NERVOUS_SYSTEM_MATURATION","pval":0.30159,"padj":0.85813,"ES":-0.94038,"NES":-1.41481,"nMoreExtreme":14462,"size":4,"leadingEdge":["CX3CR1","CDK5R1"]} {"pathway":"GO_URATE_METABOLIC_PROCESS","pval":0.00356,"padj":0.14364,"ES":-0.99927,"NES":-1.41503,"nMoreExtreme":164,"size":6,"leadingEdge":["G6PC","ABCG2"]} {"pathway":"GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_MEMBRANE_POTENTIAL","pval":0.00171,"padj":0.0907,"ES":-0.99966,"NES":-1.41558,"nMoreExtreme":78,"size":6,"leadingEdge":["TRDN"]} {"pathway":"GO_PLASMA_MEMBRANE_FUSION","pval":0.14044,"padj":0.73744,"ES":-0.97141,"NES":-1.41566,"nMoreExtreme":6612,"size":5,"leadingEdge":["CD9"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY","pval":0.0119,"padj":0.27955,"ES":-0.97773,"NES":-1.41601,"nMoreExtreme":424,"size":27,"leadingEdge":["LBH","DAB2","BRCA1","KANK2"]} {"pathway":"GO_REPLICATION_FORK_PROCESSING","pval":0.04696,"padj":0.53858,"ES":-0.94081,"NES":-1.41689,"nMoreExtreme":1607,"size":32,"leadingEdge":["EME1","TONSL","RAD51","DNA2","MMS22L","BLM","CENPS","DDX11","PCNA"]} {"pathway":"GO_INOSITOL_PHOSPHATE_METABOLIC_PROCESS","pval":0.06624,"padj":0.60375,"ES":-0.88132,"NES":-1.4175,"nMoreExtreme":2062,"size":43,"leadingEdge":["PLCD3","INPP4B","INPP5A","PLCD4","ITPKA","IMPA2"]} {"pathway":"GO_CHORIONIC_TROPHOBLAST_CELL_DIFFERENTIATION","pval":0.13283,"padj":0.72971,"ES":-0.97275,"NES":-1.41763,"nMoreExtreme":6254,"size":5,"leadingEdge":["E2F8","HTRA1","E2F7"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_5_PRODUCTION","pval":0.36699,"padj":0.89036,"ES":-0.91894,"NES":-1.4182,"nMoreExtreme":17938,"size":3,"leadingEdge":["TNFRSF21"]} {"pathway":"GO_DOPAMINERGIC_NEURON_AXON_GUIDANCE","pval":0.12916,"padj":0.72213,"ES":-0.97343,"NES":-1.41861,"nMoreExtreme":6081,"size":5,"leadingEdge":["FZD3"]} {"pathway":"GO_DIVALENT_INORGANIC_ANION_HOMEOSTASIS","pval":0.28624,"padj":0.84868,"ES":-0.94298,"NES":-1.41873,"nMoreExtreme":13726,"size":4,"leadingEdge":["SLC9A3R1"]} {"pathway":"GO_PHOSPHOLIPASE_C_ACTIVATING_DOPAMINE_RECEPTOR_SIGNALING_PATHWAY","pval":0.28624,"padj":0.84868,"ES":-0.94298,"NES":-1.41873,"nMoreExtreme":13726,"size":4,"leadingEdge":["SLC9A3R1"]} {"pathway":"GO_CELLULAR_DIVALENT_INORGANIC_ANION_HOMEOSTASIS","pval":0.28624,"padj":0.84868,"ES":-0.94298,"NES":-1.41873,"nMoreExtreme":13726,"size":4,"leadingEdge":["SLC9A3R1"]} {"pathway":"GO_MITOCHONDRIAL_DNA_REPAIR","pval":0.12657,"padj":0.72082,"ES":-0.97399,"NES":-1.41943,"nMoreExtreme":5959,"size":5,"leadingEdge":["DNA2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_OSTEOCLAST_DEVELOPMENT","pval":0.12589,"padj":0.71867,"ES":-0.9741,"NES":-1.41959,"nMoreExtreme":5927,"size":5,"leadingEdge":["TNFSF11"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_GASTRIC_ACID_SECRETION","pval":0.26791,"padj":0.83635,"ES":-0.92238,"NES":-1.41976,"nMoreExtreme":13329,"size":2,"leadingEdge":["PTGER3"]} {"pathway":"GO_TERMINATION_OF_RNA_POLYMERASE_II_TRANSCRIPTION","pval":0.05985,"padj":0.58367,"ES":-0.9304,"NES":-1.41977,"nMoreExtreme":2011,"size":34,"leadingEdge":["LSM11"]} {"pathway":"GO_REGULATION_OF_SKELETAL_MUSCLE_CONTRACTION_BY_CALCIUM_ION_SIGNALING","pval":0.27963,"padj":0.84199,"ES":-0.94416,"NES":-1.4205,"nMoreExtreme":13409,"size":4,"leadingEdge":["GSTM2"]} {"pathway":"GO_STRAND_INVASION","pval":0.11986,"padj":0.70447,"ES":-0.97517,"NES":-1.42115,"nMoreExtreme":5643,"size":5,"leadingEdge":["DMC1","XRCC2","RAD51"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CGMP_MEDIATED_SIGNALING","pval":0.27686,"padj":0.84047,"ES":-0.94467,"NES":-1.42126,"nMoreExtreme":13276,"size":4,"leadingEdge":["PDE2A","THBS1"]} {"pathway":"GO_NUCLEAR_DNA_REPLICATION","pval":0.05283,"padj":0.55951,"ES":-0.84457,"NES":-1.42166,"nMoreExtreme":1531,"size":53,"leadingEdge":["CDC45","CDT1","FEN1","POLE2","GINS1","RFC3","RFC5","RFC4","RAD51","DNA2","POLA1","POLE","FGFR1","PCNA","DONSON","ATAD5","CDC7","POLD2","LIG1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_GLUCONEOGENESIS_BY_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER","pval":0.27465,"padj":0.83769,"ES":-0.94506,"NES":-1.42185,"nMoreExtreme":13170,"size":4,"leadingEdge":["KAT2A"]} {"pathway":"GO_TRIGEMINAL_GANGLION_DEVELOPMENT","pval":0.11544,"padj":0.70006,"ES":-0.97605,"NES":-1.42243,"nMoreExtreme":5435,"size":5,"leadingEdge":["NRP1"]} {"pathway":"GO_INDUCTION_OF_BACTERIAL_AGGLUTINATION","pval":0.26154,"padj":0.83152,"ES":-0.92423,"NES":-1.42262,"nMoreExtreme":13012,"size":2,"leadingEdge":["RNASE3"]} {"pathway":"GO_REGULATION_OF_INNER_EAR_AUDITORY_RECEPTOR_CELL_DIFFERENTIATION","pval":0.27175,"padj":0.83739,"ES":-0.94558,"NES":-1.42263,"nMoreExtreme":13031,"size":4,"leadingEdge":["DLL1"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_CILIARY_TRANSITION_ZONE","pval":0.2706,"padj":0.83739,"ES":-0.94574,"NES":-1.42287,"nMoreExtreme":12976,"size":4,"leadingEdge":["CC2D2A"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_SISTER_CHROMATID_COHESION","pval":0.11257,"padj":0.69864,"ES":-0.97663,"NES":-1.42328,"nMoreExtreme":5300,"size":5,"leadingEdge":["ESPL1"]} {"pathway":"GO_RADIAL_GLIA_GUIDED_MIGRATION_OF_PURKINJE_CELL","pval":0.26804,"padj":0.83635,"ES":-0.94627,"NES":-1.42367,"nMoreExtreme":12853,"size":4,"leadingEdge":["DAB1"]} {"pathway":"GO_FOREBRAIN_VENTRICULAR_ZONE_PROGENITOR_CELL_DIVISION","pval":0.26639,"padj":0.83635,"ES":-0.94652,"NES":-1.42405,"nMoreExtreme":12774,"size":4,"leadingEdge":["FGFR1"]} {"pathway":"GO_REGULATION_OF_CELL_CHEMOTAXIS_TO_FIBROBLAST_GROWTH_FACTOR","pval":0.26639,"padj":0.83635,"ES":-0.94652,"NES":-1.42405,"nMoreExtreme":12774,"size":4,"leadingEdge":["FGFR1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_PROTEASOMAL_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS","pval":0.02942,"padj":0.43049,"ES":-0.95376,"NES":-1.42527,"nMoreExtreme":1015,"size":31,"leadingEdge":["PBK"]} {"pathway":"GO_SMOOTH_MUSCLE_CELL_MATRIX_ADHESION","pval":0.25878,"padj":0.82758,"ES":-0.94781,"NES":-1.42599,"nMoreExtreme":12409,"size":4,"leadingEdge":["PLAU"]} {"pathway":"GO_REGULATION_OF_PHOSPHOLIPASE_C_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY","pval":0.25252,"padj":0.82744,"ES":-0.92653,"NES":-1.42616,"nMoreExtreme":12563,"size":2,"leadingEdge":["GPR27"]} {"pathway":"GO_INNATE_IMMUNE_RESPONSE_IN_MUCOSA","pval":0.34122,"padj":0.87818,"ES":-0.92423,"NES":-1.42636,"nMoreExtreme":16678,"size":3,"leadingEdge":["RNASE3"]} {"pathway":"GO_MODULATION_BY_HOST_OF_VIRAL_RELEASE_FROM_HOST_CELL","pval":0.1013,"padj":0.67298,"ES":-0.97882,"NES":-1.42647,"nMoreExtreme":4769,"size":5,"leadingEdge":["PC"]} {"pathway":"GO_DNA_INTEGRITY_CHECKPOINT","pval":0.00949,"padj":0.25145,"ES":-0.71158,"NES":-1.42667,"nMoreExtreme":152,"size":152,"leadingEdge":["E2F8","TOP2A","E2F1","CDC45","CDC6","CLSPN","TICRR","CDT1","CDK1","BRCA1","DTL","WDR76","ORC1","GTSE1","EME1","CDC25C","DNA2","E2F7","CHEK1","BLM","PLK1"]} {"pathway":"GO_MICROTUBULE_BASED_PROCESS","pval":0.00053,"padj":0.04085,"ES":-0.62958,"NES":-1.42686,"nMoreExtreme":0,"size":645,"leadingEdge":["TRDN","MYBL2","SPC25","PCLAF","IFT122","KIF18B","KIF15","CDK1","BIRC5","XRCC2","BRCA1","PRC1","KIF11","TACC2","NUF2","NUSAP1","GTSE1","NDC80","AURKB","STMN1","CCNF","KIF26A","WDR62","WEE1","SKA3","KIFC1","WDR34","TTK","ESPL1","SPAG5","SKA1","AUNIP","KIF14","GAS2L3","KIF2C","ASPM","CENPA","DLGAP5","PLK4","SGO1","CHEK1","NEK2","TPX2","KIF4A","FBXO5","CDC20","KIF24","KIF20A","PLK1","KIF9","CDK5R1","KIF25","DNAAF4","LMNA","CFAP44","XRCC3","TACC3","IFT172","RTTN","CENPE","CC2D2A","KAT2A","DNAH17","CEP72","RCC1","RACGAP1","APBA1","STIL","MGARP","KIF21B","KIF22"]} {"pathway":"GO_MEIOTIC_CELL_CYCLE_PROCESS","pval":0.01097,"padj":0.27122,"ES":-0.72244,"NES":-1.427,"nMoreExtreme":192,"size":135,"leadingEdge":["CCNE2","TOP2A","MEIKIN","CDC25A","DMC1","NUF2","NCAPH","BUB1B","EME1","MYBL1","PDE3A","MND1","CDC25C","TTK","ESPL1","RAD51","ASPM","SGO1","PSMC3IP","FBXO5","BUB1","CDC20","NCAPD3","TRIP13","FBXO43","BLM","PLK1","SMC4","GPR3","SMC2","CENPS","NCAPD2","CCNE1"]} {"pathway":"GO_RESPONSE_TO_L_ASCORBIC_ACID","pval":0.25309,"padj":0.82744,"ES":-0.94883,"NES":-1.42752,"nMoreExtreme":12136,"size":4,"leadingEdge":["CAT"]} {"pathway":"GO_MYOFIBROBLAST_DIFFERENTIATION","pval":0.2471,"padj":0.82387,"ES":-0.94989,"NES":-1.42912,"nMoreExtreme":11849,"size":4,"leadingEdge":["TP53INP1"]} {"pathway":"GO_REGULATION_OF_MYOFIBROBLAST_DIFFERENTIATION","pval":0.2471,"padj":0.82387,"ES":-0.94989,"NES":-1.42912,"nMoreExtreme":11849,"size":4,"leadingEdge":["TP53INP1"]} {"pathway":"GO_TRIGLYCERIDE_RICH_LIPOPROTEIN_PARTICLE_REMODELING","pval":0.09057,"padj":0.66096,"ES":-0.98101,"NES":-1.42966,"nMoreExtreme":4264,"size":5,"leadingEdge":["LPL"]} {"pathway":"GO_VERY_LOW_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING","pval":0.09057,"padj":0.66096,"ES":-0.98101,"NES":-1.42966,"nMoreExtreme":4264,"size":5,"leadingEdge":["LPL"]} {"pathway":"GO_PURINE_RIBONUCLEOSIDE_SALVAGE","pval":0.08938,"padj":0.65946,"ES":-0.98124,"NES":-1.42999,"nMoreExtreme":4208,"size":5,"leadingEdge":["PRTFDC1"]} {"pathway":"GO_TOLL_SIGNALING_PATHWAY","pval":0.08603,"padj":0.65271,"ES":-0.98185,"NES":-1.43089,"nMoreExtreme":4050,"size":5,"leadingEdge":["NLRP12"]} {"pathway":"GO_RECOGNITION_OF_APOPTOTIC_CELL","pval":0.08567,"padj":0.65271,"ES":-0.98197,"NES":-1.43106,"nMoreExtreme":4033,"size":5,"leadingEdge":["FCN1"]} {"pathway":"GO_COMPARTMENT_PATTERN_SPECIFICATION","pval":0.08543,"padj":0.65271,"ES":-0.98202,"NES":-1.43114,"nMoreExtreme":4022,"size":5,"leadingEdge":["DLL1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MESODERM_DEVELOPMENT","pval":0.0832,"padj":0.64772,"ES":-0.98253,"NES":-1.43187,"nMoreExtreme":3917,"size":5,"leadingEdge":["SOX17"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CHROMOSOME_ORGANIZATION","pval":0.01219,"padj":0.28185,"ES":-0.73558,"NES":-1.43289,"nMoreExtreme":229,"size":122,"leadingEdge":["TOP2A","CDT1","MCM2","BRCA1","MAD2L1","NDC80","AURKB","BUB1B","CENPF","TTK","ESPL1","ATAD2","FBXO5","BUB1","CDC20","TRIP13","PLK1","XRCC3","SKI","JARID2"]} {"pathway":"GO_NCRNA_EXPORT_FROM_NUCLEUS","pval":0.06571,"padj":0.60375,"ES":-0.9167,"NES":-1.4347,"nMoreExtreme":2127,"size":38,"leadingEdge":["NDC1"]} {"pathway":"GO_PYRUVATE_TRANSMEMBRANE_TRANSPORT","pval":0.31341,"padj":0.86489,"ES":-0.92973,"NES":-1.43486,"nMoreExtreme":15319,"size":3,"leadingEdge":["SLC16A7"]} {"pathway":"GO_MOTOR_NEURON_MIGRATION","pval":0.07106,"padj":0.62112,"ES":-0.985,"NES":-1.43548,"nMoreExtreme":3345,"size":5,"leadingEdge":["NRP1","DAB1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ARACHIDONIC_ACID_SECRETION","pval":0.21666,"padj":0.80167,"ES":-0.95529,"NES":-1.43724,"nMoreExtreme":10389,"size":4,"leadingEdge":["NTSR1"]} {"pathway":"GO_CALCITONIN_FAMILY_RECEPTOR_SIGNALING_PATHWAY","pval":0.21538,"padj":0.80139,"ES":-0.95551,"NES":-1.43757,"nMoreExtreme":10328,"size":4,"leadingEdge":["CALCRL"]} {"pathway":"GO_CENTRIOLE_ASSEMBLY","pval":0.05062,"padj":0.55466,"ES":-0.9296,"NES":-1.43809,"nMoreExtreme":1670,"size":36,"leadingEdge":["BRCA1","WDR62","PLK4","RTTN","KAT2A","CEP72","STIL","CDK2"]} {"pathway":"GO_LONG_CHAIN_FATTY_ACID_CATABOLIC_PROCESS","pval":0.21234,"padj":0.79938,"ES":-0.95607,"NES":-1.43842,"nMoreExtreme":10182,"size":4,"leadingEdge":["ADTRP"]} {"pathway":"GO_ARTERIAL_ENDOTHELIAL_CELL_DIFFERENTIATION","pval":0.21082,"padj":0.79831,"ES":-0.95641,"NES":-1.43893,"nMoreExtreme":10109,"size":4,"leadingEdge":["DLL1","HEY1"]} {"pathway":"GO_RESPONSE_TO_INDOLE_3_METHANOL","pval":0.05812,"padj":0.57817,"ES":-0.98753,"NES":-1.43916,"nMoreExtreme":2736,"size":5,"leadingEdge":["BRCA1"]} {"pathway":"GO_ADENYLATE_CYCLASE_INHIBITING_G_PROTEIN_COUPLED_ACETYLCHOLINE_RECEPTOR_SIGNALING_PATHWAY","pval":0.22187,"padj":0.80586,"ES":-0.93507,"NES":-1.4393,"nMoreExtreme":11038,"size":2,"leadingEdge":["CHRM3"]} {"pathway":"GO_KERATINIZATION","pval":0.04834,"padj":0.5476,"ES":-0.93067,"NES":-1.43975,"nMoreExtreme":1595,"size":36,"leadingEdge":["KRT80","PCSK6","KRT10","KRT7"]} {"pathway":"GO_SCHWANN_CELL_MIGRATION","pval":0.2051,"padj":0.79637,"ES":-0.95742,"NES":-1.44045,"nMoreExtreme":9835,"size":4,"leadingEdge":["TIAM1"]} {"pathway":"GO_REGULATION_OF_COHESIN_LOADING","pval":0.05012,"padj":0.55243,"ES":-0.9891,"NES":-1.44145,"nMoreExtreme":2359,"size":5,"leadingEdge":["CDCA5"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_METALLOENDOPEPTIDASE_ACTIVITY","pval":0.20041,"padj":0.79183,"ES":-0.95838,"NES":-1.44188,"nMoreExtreme":9610,"size":4,"leadingEdge":["SORL1"]} {"pathway":"GO_PROLINE_TRANSMEMBRANE_TRANSPORT","pval":0.28786,"padj":0.84886,"ES":-0.93518,"NES":-1.44327,"nMoreExtreme":14070,"size":3,"leadingEdge":["SLC36A1"]} {"pathway":"GO_REGULATION_OF_THE_FORCE_OF_HEART_CONTRACTION_BY_CHEMICAL_SIGNAL","pval":0.19553,"padj":0.79001,"ES":-0.95933,"NES":-1.44332,"nMoreExtreme":9376,"size":4,"leadingEdge":["ADRB1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_BLOOD_PRESSURE_BY_EPINEPHRINE_NOREPINEPHRINE","pval":0.19553,"padj":0.79001,"ES":-0.95933,"NES":-1.44332,"nMoreExtreme":9376,"size":4,"leadingEdge":["ADRB1"]} {"pathway":"GO_REGULATION_OF_DNA_REPLICATION","pval":0.01786,"padj":0.35159,"ES":-0.7645,"NES":-1.44345,"nMoreExtreme":384,"size":99,"leadingEdge":["E2F8","CDC6","TICRR","RECQL4","DSCC1","ESCO2","CDT1","CDK1","CCNA2","CHTF18","RFC3","RFC5","RFC4","DNA2","E2F7","FBXO5","BLM","FGFR1","PCNA","DONSON","ATAD5","CDC7","ID3","CDK2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_HELICASE_ACTIVITY","pval":0.04292,"padj":0.52235,"ES":-0.99079,"NES":-1.44391,"nMoreExtreme":2020,"size":5,"leadingEdge":["MCM2"]} {"pathway":"GO_REGULATION_OF_DNA_DUPLEX_UNWINDING","pval":0.04262,"padj":0.52235,"ES":-0.99084,"NES":-1.44399,"nMoreExtreme":2006,"size":5,"leadingEdge":["TOP2A","MCM2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MAINTENANCE_OF_SISTER_CHROMATID_COHESION","pval":0.19297,"padj":0.79001,"ES":-0.95984,"NES":-1.44408,"nMoreExtreme":9253,"size":4,"leadingEdge":["SLF1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY","pval":0.03861,"padj":0.50613,"ES":-0.99163,"NES":-1.44514,"nMoreExtreme":1817,"size":5,"leadingEdge":["DHRS3"]} {"pathway":"GO_DORSAL_ROOT_GANGLION_DEVELOPMENT","pval":0.18753,"padj":0.78227,"ES":-0.96081,"NES":-1.44555,"nMoreExtreme":8992,"size":4,"leadingEdge":["NRP1"]} {"pathway":"GO_CELL_CYCLE_CHECKPOINT","pval":0.00316,"padj":0.13236,"ES":-0.69613,"NES":-1.44567,"nMoreExtreme":38,"size":207,"leadingEdge":["E2F8","TOP2A","E2F1","CDC45","CDC6","CLSPN","TICRR","CDT1","ZWINT","CDK1","BRCA1","DTL","WDR76","MAD2L1","ORC1","GTSE1","NDC80","AURKB","BUB1B","CENPF","EME1","WEE1","CDC25C","TTK","DNA2","E2F7","CHEK1","BUB1","CDC20","TRIP13","BLM","PLK1","CDKN2B","XRCC3"]} {"pathway":"GO_RECEPTOR_TRANSACTIVATION","pval":0.18571,"padj":0.77993,"ES":-0.96118,"NES":-1.44611,"nMoreExtreme":8905,"size":4,"leadingEdge":["ADRA2B"]} {"pathway":"GO_POSITIVE_REGULATION_OF_UTERINE_SMOOTH_MUSCLE_CONTRACTION","pval":0.18571,"padj":0.77993,"ES":-0.96118,"NES":-1.44611,"nMoreExtreme":8905,"size":4,"leadingEdge":["ADRA2B"]} {"pathway":"GO_MUSCULAR_SEPTUM_MORPHOGENESIS","pval":0.18517,"padj":0.77988,"ES":-0.9613,"NES":-1.44628,"nMoreExtreme":8879,"size":4,"leadingEdge":["TGFBR3"]} {"pathway":"GO_DEFINITIVE_ERYTHROCYTE_DIFFERENTIATION","pval":0.18517,"padj":0.77988,"ES":-0.9613,"NES":-1.44628,"nMoreExtreme":8879,"size":4,"leadingEdge":["TGFBR3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MITOTIC_CELL_CYCLE","pval":0.00774,"padj":0.2311,"ES":-0.7289,"NES":-1.44827,"nMoreExtreme":131,"size":141,"leadingEdge":["CD28","CDC45","TAL1","CDC25A","CDC6","RECQL4","CDT1","LRP5","CDCA5","CDK1","DTL","MAD2L1","NUSAP1","NDC80","CDC25C","PRKCA","ESPL1","INSR","UBE2C","DLGAP5","FBXO5","SLF1","XRCC3","FGFR1","CCNE1","USP2","CDC7","KIF20B","LSM11"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_HISTONE_DEACETYLATION","pval":0.20012,"padj":0.79183,"ES":-0.94102,"NES":-1.44847,"nMoreExtreme":9956,"size":2,"leadingEdge":["SKI"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_MYELINATION","pval":0.02727,"padj":0.41718,"ES":-0.9941,"NES":-1.44874,"nMoreExtreme":1283,"size":5,"leadingEdge":["TNFRSF21"]} {"pathway":"GO_INTRACILIARY_TRANSPORT_INVOLVED_IN_CILIUM_ASSEMBLY","pval":0.05384,"padj":0.56056,"ES":-0.92049,"NES":-1.44896,"nMoreExtreme":1726,"size":39,"leadingEdge":["IFT122","WDR34","IFT172","DYNC2H1"]} {"pathway":"GO_ANTIFUNGAL_HUMORAL_RESPONSE","pval":0.19572,"padj":0.79001,"ES":-0.94226,"NES":-1.45037,"nMoreExtreme":9737,"size":2,"leadingEdge":["IL36RN"]} {"pathway":"GO_REGULATION_OF_RETINA_DEVELOPMENT_IN_CAMERA_TYPE_EYE","pval":0.16586,"padj":0.7716,"ES":-0.96506,"NES":-1.45194,"nMoreExtreme":7953,"size":4,"leadingEdge":["DLX1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_FAT_CELL_PROLIFERATION","pval":0.01576,"padj":0.32311,"ES":-0.99646,"NES":-1.45218,"nMoreExtreme":741,"size":5,"leadingEdge":["E2F1"]} {"pathway":"GO_PROTEIN_METHYLATION","pval":0.00642,"padj":0.20961,"ES":-0.72497,"NES":-1.45223,"nMoreExtreme":103,"size":151,"leadingEdge":["ARMT1","BRCA1","SUV39H2","SMYD3","MYB","LMNA","JARID2","SETD6","KMT5C"]} {"pathway":"GO_REGULATION_OF_CDC42_PROTEIN_SIGNAL_TRANSDUCTION","pval":0.01427,"padj":0.30995,"ES":-0.99674,"NES":-1.45259,"nMoreExtreme":671,"size":5,"leadingEdge":["NRP1"]} {"pathway":"GO_DENDRITE_ARBORIZATION","pval":0.01427,"padj":0.30995,"ES":-0.99674,"NES":-1.45259,"nMoreExtreme":671,"size":5,"leadingEdge":["NRP1"]} {"pathway":"GO_CARNITINE_BIOSYNTHETIC_PROCESS","pval":0.15948,"padj":0.76421,"ES":-0.9663,"NES":-1.4538,"nMoreExtreme":7647,"size":4,"leadingEdge":["SHMT1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MESODERM_DEVELOPMENT","pval":0.18756,"padj":0.78227,"ES":-0.94456,"NES":-1.45391,"nMoreExtreme":9331,"size":2,"leadingEdge":["ETV2"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_CHEMOTAXIS","pval":0.18734,"padj":0.78227,"ES":-0.94462,"NES":-1.454,"nMoreExtreme":9320,"size":2,"leadingEdge":["THBS1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_FEEDING_BEHAVIOR","pval":0.18682,"padj":0.78157,"ES":-0.94479,"NES":-1.45426,"nMoreExtreme":9294,"size":2,"leadingEdge":["RETN"]} {"pathway":"GO_POSITIVE_REGULATION_OF_THYMOCYTE_APOPTOTIC_PROCESS","pval":0.00866,"padj":0.24715,"ES":-0.99809,"NES":-1.45455,"nMoreExtreme":407,"size":5,"leadingEdge":["ADAM8"]} {"pathway":"GO_FOLATE_IMPORT_ACROSS_PLASMA_MEMBRANE","pval":0.15564,"padj":0.75836,"ES":-0.96703,"NES":-1.4549,"nMoreExtreme":7463,"size":4,"leadingEdge":["SLC46A1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_DENDRITE_MORPHOGENESIS","pval":0.02423,"padj":0.39524,"ES":-0.94772,"NES":-1.45617,"nMoreExtreme":807,"size":35,"leadingEdge":["TIAM1","ITPKA","CUX2"]} {"pathway":"GO_DE_NOVO_CENTRIOLE_ASSEMBLY","pval":0.15058,"padj":0.75144,"ES":-0.96798,"NES":-1.45634,"nMoreExtreme":7220,"size":4,"leadingEdge":["PLK4"]} {"pathway":"GO_REGULATION_OF_SKELETAL_MUSCLE_CONTRACTION_BY_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION","pval":0.24439,"padj":0.82387,"ES":-0.94417,"NES":-1.45714,"nMoreExtreme":11945,"size":3,"leadingEdge":["GSTM2"]} {"pathway":"GO_CYTOSKELETON_DEPENDENT_CYTOKINESIS","pval":0.02301,"padj":0.38452,"ES":-0.80311,"NES":-1.45743,"nMoreExtreme":562,"size":78,"leadingEdge":["CDT1","ANLN","NUSAP1","AURKB","STMN1","ESPL1","CIT","CENPA","KIF4A","KIF20A","PLK1","CEP55","RACGAP1","KIF20B","EFHC1"]} {"pathway":"GO_CHROMOSOME_ORGANIZATION","pval":0.002,"padj":0.09873,"ES":-0.63157,"NES":-1.4582,"nMoreExtreme":0,"size":985,"leadingEdge":["CCNE2","TOP2A","MEIKIN","GINS2","CDC45","TAL1","CDC6","PKIB","RAD54L","MCM6","RECQL4","MCM7","EXO1","DSCC1","HELLS","MCM4","ESCO2","DMC1","KIF18B","CDT1","MCM2","FEN1","CENPM","NCAPG","CDCA5","ZWINT","OIP5","CDK1","BRCA1","PRC1","CENPU","MKI67","CCNA2","MAD2L1","CHAF1B","NCAPG2","NUF2","POLE2","NUSAP1","UHRF1","NDC80","AURKB","CENPK","NCAPH","BUB1B","CENPF","HJURP","GINS1","KIFC1","HASPIN","PRKCA","RFC3","TTK","ESPL1","SPAG5","ATAD2","RFC5","CENPI","RFC4","RAD51","KIF14","DNA2","ASF1B","JADE1","KIF2C","CHAF1A","KNL1","POLA1","CENPA","DLGAP5","SUV39H2","SGO1","CHEK1","NEK2","KIF4A","FBXO5","CDCA8","CENPP","BUB1","HMGB2","CDC20","NCAPD3","POLE","TRIP13","SMYD3","BLM","CENPH","PLK1","HMGB3","SLF1","SMC4","MYB","PHF10","SNAI1","HIRIP3","KIF25","SMC2","CENPS","CBX7","LMNA","XRCC3","TACC3","DSN1","NCAPD2","CENPE","KAT2A","CCNE1","CBX2","DDX11","GINS4","CENPN","SKI","PCNA","RACGAP1","RCCD1","JARID2","USP51"]} {"pathway":"GO_MEIOTIC_CELL_CYCLE","pval":0.00348,"padj":0.14108,"ES":-0.71362,"NES":-1.45824,"nMoreExtreme":48,"size":179,"leadingEdge":["CCNE2","TOP2A","MEIKIN","CDC25A","RAD54L","EXO1","DMC1","PKMYT1","XRCC2","NUF2","NCAPH","BUB1B","EME1","MYBL1","PDE3A","MND1","CDC25C","TTK","ESPL1","INSR","RAD51","ASPM","SGO1","NEK2","PSMC3IP","FBXO5","BUB1","CDC20","NCAPD3","MNS1","TRIP13","FBXO43","BLM","PLK1","SMC4","GPR3","SMC2","CENPS","PRKACB","NCAPD2","CCNE1"]} {"pathway":"GO_REGULATION_OF_CHROMOSOME_SEGREGATION","pval":0.01635,"padj":0.32976,"ES":-0.78137,"NES":-1.46041,"nMoreExtreme":364,"size":93,"leadingEdge":["CDC6","CDT1","FEN1","CDCA5","MKI67","MAD2L1","NDC80","AURKB","BUB1B","CENPF","TTK","ESPL1","SPAG5","KIF2C","DLGAP5","NEK2","FBXO5","BUB1","CDC20","TRIP13","PLK1","SLF1","XRCC3","TACC3","CENPE","DDX11","RACGAP1"]} {"pathway":"GO_HEMOGLOBIN_METABOLIC_PROCESS","pval":0.17144,"padj":0.77295,"ES":-0.94883,"NES":-1.46048,"nMoreExtreme":8529,"size":2,"leadingEdge":["CAT"]} {"pathway":"GO_RESPONSE_TO_PHENYLPROPANOID","pval":0.17144,"padj":0.77295,"ES":-0.94883,"NES":-1.46048,"nMoreExtreme":8529,"size":2,"leadingEdge":["CAT"]} {"pathway":"GO_CGMP_CATABOLIC_PROCESS","pval":0.13535,"padj":0.73185,"ES":-0.9709,"NES":-1.46073,"nMoreExtreme":6490,"size":4,"leadingEdge":["PDE2A"]} {"pathway":"GO_MICROTUBULE_CYTOSKELETON_ORGANIZATION_INVOLVED_IN_MITOSIS","pval":0.00952,"padj":0.25145,"ES":-0.75043,"NES":-1.46074,"nMoreExtreme":180,"size":121,"leadingEdge":["MYBL2","SPC25","BIRC5","PRC1","KIF11","TACC2","NUF2","NUSAP1","NDC80","AURKB","STMN1","WDR62","KIFC1","TTK","ESPL1","CENPA","NEK2","TPX2","KIF4A","CDC20","PLK1","TACC3","CENPE","RCC1","RACGAP1","STIL"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MAPKKK_CASCADE_BY_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY","pval":0.23254,"padj":0.81508,"ES":-0.94658,"NES":-1.46086,"nMoreExtreme":11366,"size":3,"leadingEdge":["KL","FGFR1"]} {"pathway":"GO_PEPTIDYL_LYSINE_TRIMETHYLATION","pval":0.04006,"padj":0.51243,"ES":-0.92824,"NES":-1.46115,"nMoreExtreme":1284,"size":39,"leadingEdge":["SUV39H2","LMNA","KMT5C"]} {"pathway":"GO_SENSORY_PERCEPTION_OF_SOUR_TASTE","pval":0.13362,"padj":0.72971,"ES":-0.97132,"NES":-1.46136,"nMoreExtreme":6407,"size":4,"leadingEdge":["PKD1L3","ASIC1"]} {"pathway":"GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_INCISION","pval":0.03931,"padj":0.50894,"ES":-0.92863,"NES":-1.46177,"nMoreExtreme":1260,"size":39,"leadingEdge":["RFC3","RFC5","RFC4","PCNA","POLD2"]} {"pathway":"GO_DNA_DAMAGE_RESPONSE_DETECTION_OF_DNA_DAMAGE","pval":0.03918,"padj":0.50871,"ES":-0.92869,"NES":-1.46186,"nMoreExtreme":1256,"size":39,"leadingEdge":["DTL","RFC3","RFC5","RFC4","PCNA","POLD2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CIRCADIAN_SLEEP_WAKE_CYCLE_SLEEP","pval":0.16262,"padj":0.7677,"ES":-0.95145,"NES":-1.46451,"nMoreExtreme":8090,"size":2,"leadingEdge":["GHRL"]} {"pathway":"GO_FRUCTOSE_CATABOLIC_PROCESS","pval":0.12142,"padj":0.70744,"ES":-0.97377,"NES":-1.46504,"nMoreExtreme":5822,"size":4,"leadingEdge":["KHK"]} {"pathway":"GO_REGULATION_OF_SISTER_CHROMATID_SEGREGATION","pval":0.02393,"padj":0.39206,"ES":-0.8149,"NES":-1.46505,"nMoreExtreme":598,"size":74,"leadingEdge":["CDC6","CDT1","FEN1","CDCA5","MAD2L1","NDC80","AURKB","BUB1B","CENPF","TTK","ESPL1","DLGAP5","FBXO5","BUB1","CDC20","TRIP13","PLK1","SLF1","XRCC3","TACC3","CENPE","DDX11"]} {"pathway":"GO_MICROTUBULE_BASED_MOVEMENT","pval":0.00127,"padj":0.07505,"ES":-0.69745,"NES":-1.46507,"nMoreExtreme":13,"size":230,"leadingEdge":["IFT122","KIF18B","KIF15","KIF11","KIF26A","KIFC1","WDR34","KIF14","KIF2C","DLGAP5","KIF4A","KIF24","KIF20A","KIF9","KIF25","DNAAF4","IFT172","CENPE","DNAH17","RACGAP1","APBA1","MGARP","KIF21B","KIF22","KIF20B","DYNC2H1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ADIPOSE_TISSUE_DEVELOPMENT","pval":0.12063,"padj":0.7062,"ES":-0.97394,"NES":-1.46529,"nMoreExtreme":5784,"size":4,"leadingEdge":["GHRL"]} {"pathway":"GO_CHROMATIN_ASSEMBLY_OR_DISASSEMBLY","pval":0.01233,"padj":0.28197,"ES":-0.77046,"NES":-1.46604,"nMoreExtreme":254,"size":105,"leadingEdge":["TAL1","HELLS","MCM2","CENPM","OIP5","CENPU","CHAF1B","CENPK","HJURP","CENPI","ASF1B","CHAF1A","KNL1","CENPA","SUV39H2","CENPP","HMGB2","SMYD3","CENPH","HIRIP3","CENPS","CENPN","CENPQ"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CELL_CELL_ADHESION_MEDIATED_BY_CADHERIN","pval":0.1155,"padj":0.70006,"ES":-0.97495,"NES":-1.46681,"nMoreExtreme":5538,"size":4,"leadingEdge":["NEXMIF"]} {"pathway":"GO_PEPTIDYL_ASPARAGINE_MODIFICATION","pval":0.01392,"padj":0.30691,"ES":-0.96129,"NES":-1.46692,"nMoreExtreme":467,"size":34,"leadingEdge":["DERL3"]} {"pathway":"GO_DNA_REPAIR_COMPLEX_ASSEMBLY","pval":0.11446,"padj":0.70006,"ES":-0.97512,"NES":-1.46707,"nMoreExtreme":5488,"size":4,"leadingEdge":["DMC1","RAD51"]} {"pathway":"GO_CEREBRAL_CORTEX_REGIONALIZATION","pval":0.11392,"padj":0.69895,"ES":-0.97523,"NES":-1.46724,"nMoreExtreme":5462,"size":4,"leadingEdge":["ADGRG1"]} {"pathway":"GO_DUCTUS_ARTERIOSUS_CLOSURE","pval":0.11344,"padj":0.69895,"ES":-0.97534,"NES":-1.46741,"nMoreExtreme":5439,"size":4,"leadingEdge":["HPGD"]} {"pathway":"GO_HISTONE_EXCHANGE","pval":0.02798,"padj":0.41828,"ES":-0.93815,"NES":-1.46826,"nMoreExtreme":905,"size":38,"leadingEdge":["CENPM","OIP5","CENPU","CENPK","HJURP","CENPI","KNL1","CENPA","CENPP","CENPH","CENPS","CENPN","CENPQ"]} {"pathway":"GO_TESTOSTERONE_BIOSYNTHETIC_PROCESS","pval":0.15395,"padj":0.75438,"ES":-0.95394,"NES":-1.46835,"nMoreExtreme":7659,"size":2,"leadingEdge":["CYP19A1"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SPINDLE_ASSEMBLY","pval":0.1087,"padj":0.69331,"ES":-0.97641,"NES":-1.46901,"nMoreExtreme":5212,"size":4,"leadingEdge":["SPAG5"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_TEMPERATURE_STIMULUS","pval":0.10616,"padj":0.68361,"ES":-0.97691,"NES":-1.46977,"nMoreExtreme":5090,"size":4,"leadingEdge":["HTR2B"]} {"pathway":"GO_ESTABLISHMENT_OR_MAINTENANCE_OF_BIPOLAR_CELL_POLARITY","pval":0.03993,"padj":0.51243,"ES":-0.92333,"NES":-1.47086,"nMoreExtreme":1263,"size":41,"leadingEdge":["FSCN1","ANK1","LRRC7","SLC9A3R1"]} {"pathway":"GO_DNA_REPAIR","pval":0.00029,"padj":0.02766,"ES":-0.65926,"NES":-1.47167,"nMoreExtreme":0,"size":501,"leadingEdge":["GINS2","CDC45","RAD54L","PCLAF","CLSPN","TICRR","RECQL4","EXO1","EEPD1","ESCO2","DMC1","FEN1","CDCA5","CDK1","XRCC2","BRCA1","DTL","NEIL3","CHAF1B","POLE2","UHRF1","UBE2T","UNG","EME1","FANCE","TONSL","POLQ","RFC3","TP73","MCM8","RFC5","AUNIP","RFC4","RAD51","DNA2","FANCB","MMS22L","FOXM1","WDHD1","FANCG","CHAF1A","FANCI","PARP2","POLA1","CHEK1","HMGB2","POLE","TRIP13","BLM","SLF1","CENPS","RAD51AP1","NUDT1","XRCC3","DDX11","GINS4","PCNA","USP51"]} {"pathway":"GO_INTESTINE_SMOOTH_MUSCLE_CONTRACTION","pval":0.19848,"padj":0.79183,"ES":-0.95381,"NES":-1.47203,"nMoreExtreme":9701,"size":3,"leadingEdge":["GHRL","HTR2B"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CELL_CYCLE_PROCESS","pval":0.00078,"padj":0.05368,"ES":-0.69691,"NES":-1.47251,"nMoreExtreme":7,"size":245,"leadingEdge":["E2F8","E2F1","CD28","CDC45","CDC25A","CDC6","RECQL4","CDT1","LRP5","FEN1","CDCA5","CDK1","BRCA1","DTL","MAD2L1","NUSAP1","GTSE1","NDC80","AURKB","CDC25C","TP73","ESPL1","SPAG5","CIT","INSR","KIF14","E2F7","UBE2C","DLGAP5","PLK4","FBXO5","SLF1","CDK5R1","XRCC3","FAM83D","FGFR1","CCNE1","DDX11","PCNA","RACGAP1","ATAD5","CDC7","KIF20B","LSM11","CDK2"]} {"pathway":"GO_CYTOPLASMIC_TRANSLATIONAL_INITIATION","pval":0.00192,"padj":0.0971,"ES":-0.99302,"NES":-1.473,"nMoreExtreme":66,"size":30,"leadingEdge":["TICRR"]} {"pathway":"GO_RESPONSE_TO_DISACCHARIDE","pval":0.18958,"padj":0.78762,"ES":-0.95557,"NES":-1.47473,"nMoreExtreme":9266,"size":3,"leadingEdge":["KHK","CALCRL"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SEQUESTERING_OF_TRIGLYCERIDE","pval":0.08714,"padj":0.65493,"ES":-0.98101,"NES":-1.47594,"nMoreExtreme":4178,"size":4,"leadingEdge":["LPL"]} {"pathway":"GO_CHYLOMICRON_REMODELING","pval":0.08714,"padj":0.65493,"ES":-0.98101,"NES":-1.47594,"nMoreExtreme":4178,"size":4,"leadingEdge":["LPL"]} {"pathway":"GO_DNA_REPLICATION_INDEPENDENT_NUCLEOSOME_ORGANIZATION","pval":0.02519,"padj":0.40148,"ES":-0.9382,"NES":-1.47684,"nMoreExtreme":807,"size":39,"leadingEdge":["CENPM","OIP5","CENPU","CENPK","HJURP","CENPI","ASF1B","KNL1","CENPA","CENPP","CENPH","CENPS","CENPN","CENPQ"]} {"pathway":"GO_SKELETAL_MUSCLE_TISSUE_GROWTH","pval":0.08235,"padj":0.64602,"ES":-0.98202,"NES":-1.47746,"nMoreExtreme":3948,"size":4,"leadingEdge":["DLL1"]} {"pathway":"GO_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_GROWTH","pval":0.08235,"padj":0.64602,"ES":-0.98202,"NES":-1.47746,"nMoreExtreme":3948,"size":4,"leadingEdge":["DLL1"]} {"pathway":"GO_PROXIMAL_TUBULE_DEVELOPMENT","pval":0.08235,"padj":0.64602,"ES":-0.98202,"NES":-1.47746,"nMoreExtreme":3948,"size":4,"leadingEdge":["DLL1"]} {"pathway":"GO_CYTOPLASMIC_TRANSLATION","pval":0.01489,"padj":0.31301,"ES":-0.79609,"NES":-1.47822,"nMoreExtreme":341,"size":89,"leadingEdge":["TICRR","RBM24"]} {"pathway":"GO_INNER_MITOCHONDRIAL_MEMBRANE_ORGANIZATION","pval":0.04154,"padj":0.51963,"ES":-0.91487,"NES":-1.47835,"nMoreExtreme":1279,"size":44,"leadingEdge":["UQCC3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING","pval":0.01427,"padj":0.30995,"ES":-0.95594,"NES":-1.47884,"nMoreExtreme":470,"size":36,"leadingEdge":["PKIB","AURKB","NEK2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_PROTEIN_TARGETING_TO_MITOCHONDRION","pval":0.00055,"padj":0.04131,"ES":-0.99707,"NES":-1.47901,"nMoreExtreme":18,"size":30,"leadingEdge":["ABLIM3"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_EPINEPHRINE_SECRETION","pval":0.12867,"padj":0.72213,"ES":-0.96119,"NES":-1.4795,"nMoreExtreme":6401,"size":2,"leadingEdge":["ADRA2B"]} {"pathway":"GO_PROXIMAL_DISTAL_PATTERN_FORMATION_INVOLVED_IN_NEPHRON_DEVELOPMENT","pval":0.1759,"padj":0.77529,"ES":-0.95871,"NES":-1.47959,"nMoreExtreme":8597,"size":3,"leadingEdge":["IRX3"]} {"pathway":"GO_HAIR_FOLLICLE_PLACODE_FORMATION","pval":0.06965,"padj":0.61674,"ES":-0.98466,"NES":-1.48144,"nMoreExtreme":3339,"size":4,"leadingEdge":["EDA"]} {"pathway":"GO_MEIOTIC_DNA_DOUBLE_STRAND_BREAK_PROCESSING","pval":0.16561,"padj":0.7709,"ES":-0.96102,"NES":-1.48314,"nMoreExtreme":8094,"size":3,"leadingEdge":["BLM"]} {"pathway":"GO_VASCULOGENESIS_INVOLVED_IN_CORONARY_VASCULAR_MORPHOGENESIS","pval":0.16446,"padj":0.76986,"ES":-0.9613,"NES":-1.48358,"nMoreExtreme":8038,"size":3,"leadingEdge":["TGFBR3"]} {"pathway":"GO_LYMPHOCYTE_ANERGY","pval":0.15986,"padj":0.76421,"ES":-0.96237,"NES":-1.48522,"nMoreExtreme":7813,"size":3,"leadingEdge":["PHLPP1"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_HISTONE_H3_K4_METHYLATION","pval":0.05584,"padj":0.56779,"ES":-0.98753,"NES":-1.48575,"nMoreExtreme":2677,"size":4,"leadingEdge":["BRCA1"]} {"pathway":"GO_CENTROMERE_COMPLEX_ASSEMBLY","pval":0.02262,"padj":0.3799,"ES":-0.93831,"NES":-1.48598,"nMoreExtreme":719,"size":40,"leadingEdge":["HELLS","CENPM","OIP5","CENPU","CENPK","CENPF","HJURP","CENPI","KNL1","CENPA","CENPP","CENPH","CENPS","CENPE","CENPN","CENPQ"]} {"pathway":"GO_REGULATION_OF_CELLULAR_PH_REDUCTION","pval":0.11225,"padj":0.69864,"ES":-0.96591,"NES":-1.48677,"nMoreExtreme":5584,"size":2,"leadingEdge":["BCL2"]} {"pathway":"GO_POSITIVE_REGULATION_OF_SKELETAL_MUSCLE_FIBER_DEVELOPMENT","pval":0.11225,"padj":0.69864,"ES":-0.96591,"NES":-1.48677,"nMoreExtreme":5584,"size":2,"leadingEdge":["BCL2"]} {"pathway":"GO_CYTOKINESIS","pval":0.00534,"padj":0.18862,"ES":-0.75445,"NES":-1.49023,"nMoreExtreme":93,"size":135,"leadingEdge":["E2F8","CDC6","CDT1","ANLN","PRC1","NUSAP1","AURKB","STMN1","ESPL1","CIT","KIF14","E2F7","CENPA","KIF4A","KIF20A","PLK1","CEP55"]} {"pathway":"GO_PH_ELEVATION","pval":0.14411,"padj":0.74343,"ES":-0.9659,"NES":-1.49068,"nMoreExtreme":7043,"size":3,"leadingEdge":["BCL2"]} {"pathway":"GO_CHROMATIN_REMODELING","pval":0.00441,"padj":0.1652,"ES":-0.75261,"NES":-1.49173,"nMoreExtreme":75,"size":139,"leadingEdge":["HELLS","CENPM","OIP5","CENPU","CENPK","HJURP","CENPI","KNL1","CENPA","SUV39H2","CENPP","HMGB2","CENPH","HMGB3","MYB","CENPS","KAT2A","CENPN","JARID2","CENPQ"]} {"pathway":"GO_METAPHASE_ANAPHASE_TRANSITION_OF_CELL_CYCLE","pval":0.02956,"padj":0.43049,"ES":-0.88701,"NES":-1.4931,"nMoreExtreme":856,"size":53,"leadingEdge":["CDC6","CDT1","MAD2L1","NDC80","AURKB","BUB1B","CENPF","TTK","ESPL1","DLGAP5","FBXO5","BUB1","CDC20","TRIP13","PLK1","XRCC3","TACC3","CENPE"]} {"pathway":"GO_MYOBLAST_FATE_COMMITMENT","pval":0.02529,"padj":0.40191,"ES":-0.99433,"NES":-1.49597,"nMoreExtreme":1212,"size":4,"leadingEdge":["EPAS1"]} {"pathway":"GO_CIRCADIAN_SLEEP_WAKE_CYCLE_NON_REM_SLEEP","pval":0.02004,"padj":0.36056,"ES":-0.99545,"NES":-1.49766,"nMoreExtreme":960,"size":4,"leadingEdge":["GHRL"]} {"pathway":"GO_REGULATION_OF_CORTISOL_SECRETION","pval":0.02004,"padj":0.36056,"ES":-0.99545,"NES":-1.49766,"nMoreExtreme":960,"size":4,"leadingEdge":["GHRL"]} {"pathway":"GO_POSITIVE_REGULATION_OF_GROWTH_HORMONE_SECRETION","pval":0.02004,"padj":0.36056,"ES":-0.99545,"NES":-1.49766,"nMoreExtreme":960,"size":4,"leadingEdge":["GHRL"]} {"pathway":"GO_EQUILIBRIOCEPTION","pval":0.08777,"padj":0.65613,"ES":-0.97321,"NES":-1.49801,"nMoreExtreme":4366,"size":2,"leadingEdge":["MYO7A"]} {"pathway":"GO_POSITIVE_REGULATION_OF_HEMATOPOIETIC_STEM_CELL_PROLIFERATION","pval":0.01712,"padj":0.33967,"ES":-0.99612,"NES":-1.49868,"nMoreExtreme":820,"size":4,"leadingEdge":["KITLG"]} {"pathway":"GO_FUSION_OF_SPERM_TO_EGG_PLASMA_MEMBRANE_INVOLVED_IN_SINGLE_FERTILIZATION","pval":0.11927,"padj":0.70349,"ES":-0.97141,"NES":-1.49918,"nMoreExtreme":5829,"size":3,"leadingEdge":["CD9"]} {"pathway":"GO_MANGANESE_ION_TRANSMEMBRANE_TRANSPORT","pval":0.01224,"padj":0.28185,"ES":-0.99725,"NES":-1.50037,"nMoreExtreme":586,"size":4,"leadingEdge":["SLC11A1"]} {"pathway":"GO_RESPONSE_TO_ANESTHETIC","pval":0.02206,"padj":0.376,"ES":-0.93292,"NES":-1.5005,"nMoreExtreme":686,"size":43,"leadingEdge":["CCNA2","CRHBP","TIAM1"]} {"pathway":"GO_APOPTOTIC_CHROMOSOME_CONDENSATION","pval":0.01109,"padj":0.27328,"ES":-0.99753,"NES":-1.50079,"nMoreExtreme":531,"size":4,"leadingEdge":["TOP2A"]} {"pathway":"GO_CELL_CYCLE_DNA_REPLICATION","pval":0.02222,"padj":0.37664,"ES":-0.86039,"NES":-1.5012,"nMoreExtreme":598,"size":63,"leadingEdge":["E2F8","CDC45","CDT1","FEN1","POLE2","GINS1","RFC3","RFC5","RFC4","RAD51","DNA2","E2F7","POLA1","FBXO5","POLE","FGFR1","PCNA","DONSON","ATAD5","CDC7","POLD2","LIG1"]} {"pathway":"GO_DNA_DEPENDENT_DNA_REPLICATION_MAINTENANCE_OF_FIDELITY","pval":0.01845,"padj":0.35375,"ES":-0.93836,"NES":-1.50217,"nMoreExtreme":579,"size":42,"leadingEdge":["EME1","TONSL","RAD51","DNA2","MMS22L","POLE","BLM","CENPS","DDX11","PCNA","DONSON"]} {"pathway":"GO_CILIARY_BASAL_BODY_PLASMA_MEMBRANE_DOCKING","pval":0.01014,"padj":0.25928,"ES":-0.80142,"NES":-1.50348,"nMoreExtreme":223,"size":95,"leadingEdge":["CDK1","PLK4","NEK2","KIF24","PLK1","CC2D2A","CEP72","PCNT"]} {"pathway":"GO_SPINDLE_ASSEMBLY","pval":0.00957,"padj":0.25147,"ES":-0.80025,"NES":-1.50617,"nMoreExtreme":208,"size":97,"leadingEdge":["MYBL2","BIRC5","KIF11","AURKB","KIFC1","SPAG5","ASPM","NEK2","TPX2","KIF4A","FBXO5","CDC20","PLK1","RCC1","RACGAP1"]} {"pathway":"GO_REGULATION_OF_BONE_MINERALIZATION_INVOLVED_IN_BONE_MATURATION","pval":0.09781,"padj":0.66591,"ES":-0.97652,"NES":-1.50707,"nMoreExtreme":4780,"size":3,"leadingEdge":["RFLNB"]} {"pathway":"GO_MITOTIC_CELL_CYCLE_CHECKPOINT","pval":0.00276,"padj":0.12122,"ES":-0.74939,"NES":-1.50755,"nMoreExtreme":42,"size":157,"leadingEdge":["E2F8","TOP2A","E2F1","CDC6","CLSPN","TICRR","CDT1","ZWINT","CDK1","BRCA1","MAD2L1","ORC1","GTSE1","NDC80","AURKB","BUB1B","CENPF","EME1","WEE1","CDC25C","TTK","E2F7","BUB1","CDC20","TRIP13","BLM","PLK1","CDKN2B","XRCC3"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY","pval":0.09374,"padj":0.66439,"ES":-0.97748,"NES":-1.50854,"nMoreExtreme":4581,"size":3,"leadingEdge":["PRKCA"]} {"pathway":"GO_POSITIVE_REGULATION_OF_MEIOTIC_CELL_CYCLE_PHASE_TRANSITION","pval":0.09261,"padj":0.66428,"ES":-0.97776,"NES":-1.50898,"nMoreExtreme":4526,"size":3,"leadingEdge":["CDC25A","CDC25C"]} {"pathway":"GO_NON_MOTILE_CILIUM_ASSEMBLY","pval":0.02738,"padj":0.41718,"ES":-0.90774,"NES":-1.51033,"nMoreExtreme":811,"size":50,"leadingEdge":["IFT122","IFT172","CC2D2A"]} {"pathway":"GO_HOMOLOGOUS_RECOMBINATION","pval":0.00933,"padj":0.24994,"ES":-0.95418,"NES":-1.51111,"nMoreExtreme":296,"size":40,"leadingEdge":["TOP2A","DMC1","EME1","MND1","RAD51","PSMC3IP","TRIP13","BLM","CENPS"]} {"pathway":"GO_RE_ENTRY_INTO_MITOTIC_CELL_CYCLE","pval":0.05738,"padj":0.57368,"ES":-0.98259,"NES":-1.51244,"nMoreExtreme":2854,"size":2,"leadingEdge":["CCNF"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_6_BIOSYNTHETIC_PROCESS","pval":0.07541,"padj":0.63068,"ES":-0.98191,"NES":-1.51539,"nMoreExtreme":3685,"size":3,"leadingEdge":["GHRL","NLRP12"]} {"pathway":"GO_CELLULAR_RESPONSE_TO_FRUCTOSE_STIMULUS","pval":0.07404,"padj":0.62748,"ES":-0.98225,"NES":-1.51591,"nMoreExtreme":3618,"size":3,"leadingEdge":["SLC2A5"]} {"pathway":"GO_INTESTINAL_HEXOSE_ABSORPTION","pval":0.07404,"padj":0.62748,"ES":-0.98225,"NES":-1.51591,"nMoreExtreme":3618,"size":3,"leadingEdge":["SLC2A5"]} {"pathway":"GO_MITOTIC_SPINDLE_ORGANIZATION","pval":0.00759,"padj":0.22825,"ES":-0.80116,"NES":-1.5168,"nMoreExtreme":160,"size":101,"leadingEdge":["MYBL2","SPC25","BIRC5","PRC1","KIF11","TACC2","NUF2","NDC80","AURKB","STMN1","WDR62","KIFC1","TTK","NEK2","TPX2","KIF4A","CDC20","PLK1","TACC3","CENPE","RCC1","RACGAP1","STIL"]} {"pathway":"GO_REGULATION_OF_CHROMOSOME_SEPARATION","pval":0.02148,"padj":0.37019,"ES":-0.88699,"NES":-1.51778,"nMoreExtreme":606,"size":57,"leadingEdge":["CDC6","CDT1","MAD2L1","NDC80","AURKB","BUB1B","CENPF","TTK","ESPL1","DLGAP5","FBXO5","BUB1","CDC20","TRIP13","PLK1","XRCC3","TACC3","CENPE"]} {"pathway":"GO_REGULATION_OF_SOMATIC_STEM_CELL_POPULATION_MAINTENANCE","pval":0.05982,"padj":0.58367,"ES":-0.98543,"NES":-1.52082,"nMoreExtreme":2923,"size":3,"leadingEdge":["LBH"]} {"pathway":"GO_AGGRESSIVE_BEHAVIOR","pval":0.05949,"padj":0.58367,"ES":-0.98551,"NES":-1.52094,"nMoreExtreme":2907,"size":3,"leadingEdge":["CRHBP"]} {"pathway":"GO_CORTICOTROPIN_SECRETION","pval":0.05925,"padj":0.58367,"ES":-0.98556,"NES":-1.52102,"nMoreExtreme":2895,"size":3,"leadingEdge":["GHRL","CRHBP"]} {"pathway":"GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_DEVELOPMENT","pval":0.03957,"padj":0.51046,"ES":-0.99028,"NES":-1.52831,"nMoreExtreme":1933,"size":3,"leadingEdge":["CDH5"]} {"pathway":"GO_ACROSOMAL_VESICLE_EXOCYTOSIS","pval":0.03875,"padj":0.50613,"ES":-0.99051,"NES":-1.52865,"nMoreExtreme":1893,"size":3,"leadingEdge":["SYT6"]} {"pathway":"GO_CIRCADIAN_SLEEP_WAKE_CYCLE_REM_SLEEP","pval":0.01473,"padj":0.31281,"ES":-0.99545,"NES":-1.53224,"nMoreExtreme":732,"size":2,"leadingEdge":["GHRL"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CORTICOTROPIN_SECRETION","pval":0.01473,"padj":0.31281,"ES":-0.99545,"NES":-1.53224,"nMoreExtreme":732,"size":2,"leadingEdge":["GHRL"]} {"pathway":"GO_REGULATION_OF_NUCLEAR_DIVISION","pval":0.00138,"padj":0.07928,"ES":-0.74744,"NES":-1.53368,"nMoreExtreme":18,"size":184,"leadingEdge":["CCNE2","CD28","CDC6","CDT1","LRP5","CDCA5","PKMYT1","ANLN","MKI67","CCNA2","KIF11","MAD2L1","NUSAP1","NDC80","AURKB","CCNF","BUB1B","CENPF","PDE3A","CDC25C","TTK","ESPL1","INSR","UBE2C","DLGAP5","CCNB2","CHEK1","NEK2","FBXO5","BUB1","CDC20","TRIP13","FBXO43","PLK1","SLF1","GPR3","KIF25","XRCC3","TACC3","CENPE","CCNE1","RCC1"]} {"pathway":"GO_LOBAR_BRONCHUS_EPITHELIUM_DEVELOPMENT","pval":0.01126,"padj":0.27533,"ES":-0.99657,"NES":-1.53397,"nMoreExtreme":559,"size":2,"leadingEdge":["AGR2"]} {"pathway":"GO_LOBAR_BRONCHUS_DEVELOPMENT","pval":0.01126,"padj":0.27533,"ES":-0.99657,"NES":-1.53397,"nMoreExtreme":559,"size":2,"leadingEdge":["AGR2"]} {"pathway":"GO_ADULT_FEEDING_BEHAVIOR","pval":0.01884,"padj":0.35375,"ES":-0.99545,"NES":-1.53628,"nMoreExtreme":920,"size":3,"leadingEdge":["GHRL"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_CIRCADIAN_SLEEP_WAKE_CYCLE_SLEEP","pval":0.01884,"padj":0.35375,"ES":-0.99545,"NES":-1.53628,"nMoreExtreme":920,"size":3,"leadingEdge":["GHRL"]} {"pathway":"GO_POSITIVE_REGULATION_OF_CORTISOL_SECRETION","pval":0.01884,"padj":0.35375,"ES":-0.99545,"NES":-1.53628,"nMoreExtreme":920,"size":3,"leadingEdge":["GHRL"]} {"pathway":"GO_REGULATION_OF_EATING_BEHAVIOR","pval":0.01884,"padj":0.35375,"ES":-0.99545,"NES":-1.53628,"nMoreExtreme":920,"size":3,"leadingEdge":["GHRL"]} {"pathway":"GO_POSITIVE_REGULATION_OF_GLUCOCORTICOID_SECRETION","pval":0.01884,"padj":0.35375,"ES":-0.99545,"NES":-1.53628,"nMoreExtreme":920,"size":3,"leadingEdge":["GHRL"]} {"pathway":"GO_INTRACILIARY_TRANSPORT","pval":0.01904,"padj":0.35444,"ES":-0.92044,"NES":-1.53722,"nMoreExtreme":558,"size":51,"leadingEdge":["IFT122","WDR34","IFT172","DYNC2H1"]} {"pathway":"GO_RECOMBINATIONAL_REPAIR","pval":0.00318,"padj":0.13259,"ES":-0.79427,"NES":-1.54184,"nMoreExtreme":60,"size":119,"leadingEdge":["GINS2","CDC45","RAD54L","RECQL4","DMC1","FEN1","XRCC2","BRCA1","TONSL","POLQ","MCM8","AUNIP","RAD51","FANCB","MMS22L","CHEK1","BLM","RAD51AP1","XRCC3","GINS4","USP51","CDC7"]} {"pathway":"GO_NEGATIVE_REGULATION_OF_NUCLEOTIDE_BIOSYNTHETIC_PROCESS","pval":0.00229,"padj":0.10714,"ES":-0.99955,"NES":-1.54261,"nMoreExtreme":111,"size":3,"leadingEdge":["PID1"]} {"pathway":"GO_GROWTH_INVOLVED_IN_HEART_MORPHOGENESIS","pval":0.00082,"padj":0.05464,"ES":-0.99983,"NES":-1.54304,"nMoreExtreme":39,"size":3,"leadingEdge":["S1PR1"]} {"pathway":"GO_CHROMATIN_ASSEMBLY","pval":0.00845,"padj":0.24226,"ES":-0.85362,"NES":-1.56368,"nMoreExtreme":201,"size":82,"leadingEdge":["HELLS","MCM2","CENPM","OIP5","CENPU","CHAF1B","CENPK","HJURP","CENPI","ASF1B","CHAF1A","KNL1","CENPA","CENPP","HMGB2","SMYD3","CENPH","CENPS","CENPN","CENPQ"]} {"pathway":"GO_GLUCAN_METABOLIC_PROCESS","pval":0.01131,"padj":0.27533,"ES":-0.9039,"NES":-1.56753,"nMoreExtreme":308,"size":61,"leadingEdge":["PCDH12","G6PC","INSR","KHK","PASK","IRS2","PPP1R3G"]} {"pathway":"GO_SPLICEOSOMAL_COMPLEX_ASSEMBLY","pval":0.0093,"padj":0.24994,"ES":-0.92598,"NES":-1.5726,"nMoreExtreme":265,"size":55,"leadingEdge":["WEE2-AS1"]} {"pathway":"GO_TRANSCRIPTION_BY_RNA_POLYMERASE_III","pval":0.00555,"padj":0.1941,"ES":-0.93878,"NES":-1.58026,"nMoreExtreme":160,"size":53,"leadingEdge":["BRCA1"]} {"pathway":"GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME","pval":0.00674,"padj":0.21525,"ES":-0.87232,"NES":-1.58303,"nMoreExtreme":164,"size":78,"leadingEdge":["ESCO2","CDT1","CDCA5","CDK1","NDC80","AURKB","BUB1B","HASPIN","TTK","MCM8","KNL1","CENPA","PLK1","SLF1"]} {"pathway":"GO_INTERSTRAND_CROSS_LINK_REPAIR","pval":0.00252,"padj":0.11479,"ES":-0.95037,"NES":-1.59977,"nMoreExtreme":72,"size":53,"leadingEdge":["UBE2T","EME1","FANCE","MCM8","RAD51","FANCB","FANCG","FANCI","CENPS","RAD51AP1","XRCC3"]} {"pathway":"GO_ORGANELLE_FISSION","pval":0.00019,"padj":0.02092,"ES":-0.72955,"NES":-1.60271,"nMoreExtreme":0,"size":391,"leadingEdge":["CCNE2","TOP2A","MEIKIN","CD28","MYBL2","CDC6","DSCC1","DMC1","KIF18B","CDT1","LRP5","NCAPG","CDCA5","ZWINT","PKMYT1","BIRC5","ANLN","PRC1","MKI67","CCNA2","KIF11","MAD2L1","NUF2","NUSAP1","NDC80","AURKB","NCAPH","CCNF","BUB1B","CENPF","EME1","MYBL1","KIFC1","HASPIN","PDE3A","MND1","CDC25C","TTK","ESPL1","SPAG5","INSR","RAD51","KIF14","KIF2C","ASPM","UBE2C","DLGAP5","SGO1","CCNB2","CHEK1","NEK2","PSMC3IP","TPX2","KIF4A","FBXO5","CDCA8","BUB1","CDC20","NCAPD3","TRIP13","FBXO43","BLM","PLK1","SLF1","SMC4","GPR3","KIF25","SMC2","CENPS","XRCC3","TACC3","DSN1","NCAPD2","CENPE","CCNE1","RCC1","RACGAP1","NCAPH2","BMP4","KIF22"]} {"pathway":"GO_ATP_DEPENDENT_CHROMATIN_REMODELING","pval":0.00384,"padj":0.15084,"ES":-0.93043,"NES":-1.61353,"nMoreExtreme":104,"size":61,"leadingEdge":["CENPM","OIP5","CENPU","CENPK","HJURP","CENPI","KNL1","CENPA","CENPP","CENPH","CENPS","CENPN","CENPQ"]} {"pathway":"GO_NUCLEOTIDE_EXCISION_REPAIR","pval":0.0016,"padj":0.08793,"ES":-0.84753,"NES":-1.61513,"nMoreExtreme":32,"size":106,"leadingEdge":["NEIL3","RFC3","RFC5","RFC4","POLE","PCNA","POLD2","LIG1"]} {"pathway":"GO_PROTEIN_TRANSPORT_ALONG_MICROTUBULE","pval":0.00477,"padj":0.17511,"ES":-0.92039,"NES":-1.61716,"nMoreExtreme":126,"size":65,"leadingEdge":["IFT122","WDR34","IFT172","DYNC2H1"]} {"pathway":"GO_ENERGY_RESERVE_METABOLIC_PROCESS","pval":0.00469,"padj":0.17379,"ES":-0.91605,"NES":-1.61771,"nMoreExtreme":122,"size":67,"leadingEdge":["PCDH12","PID1","G6PC","KL","INSR","KHK","PASK"]} {"pathway":"GO_SPINDLE_ORGANIZATION","pval":0.00051,"padj":0.04002,"ES":-0.8064,"NES":-1.62225,"nMoreExtreme":7,"size":157,"leadingEdge":["MYBL2","SPC25","BIRC5","PRC1","KIF11","TACC2","NUF2","NDC80","AURKB","STMN1","WDR62","KIFC1","TTK","ESPL1","SPAG5","AUNIP","ASPM","NEK2","TPX2","KIF4A","FBXO5","CDC20","PLK1","TACC3","CENPE","CEP72","RCC1","RACGAP1","STIL"]} {"pathway":"GO_CHROMOSOME_SEPARATION","pval":0.00323,"padj":0.13339,"ES":-0.89552,"NES":-1.63209,"nMoreExtreme":77,"size":80,"leadingEdge":["TOP2A","CDC6","CDT1","MAD2L1","NDC80","AURKB","NCAPH","BUB1B","CENPF","EME1","TTK","ESPL1","DLGAP5","FBXO5","BUB1","CDC20","NCAPD3","TRIP13","BLM","PLK1","CENPS","XRCC3","TACC3","NCAPD2","CENPE"]} {"pathway":"GO_SISTER_CHROMATID_SEGREGATION","pval":0.0002,"padj":0.02173,"ES":-0.80831,"NES":-1.641,"nMoreExtreme":2,"size":170,"leadingEdge":["TOP2A","MEIKIN","CDC6","DSCC1","ESCO2","KIF18B","CDT1","FEN1","NCAPG","CDCA5","ZWINT","PRC1","MAD2L1","NUF2","NUSAP1","NDC80","AURKB","NCAPH","BUB1B","CENPF","KIFC1","HASPIN","TTK","ESPL1","SPAG5","KIF14","KIF2C","DLGAP5","SGO1","NEK2","KIF4A","FBXO5","CDCA8","BUB1","CDC20","NCAPD3","TRIP13","PLK1","SLF1","SMC4","KIF25","SMC2","XRCC3","TACC3","DSN1","NCAPD2","CENPE","DDX11","RACGAP1","NCAPH2","KIF22"]} {"pathway":"GO_DNA_GEOMETRIC_CHANGE","pval":0.0013,"padj":0.07629,"ES":-0.88545,"NES":-1.65493,"nMoreExtreme":28,"size":93,"leadingEdge":["TOP2A","GINS2","CDC45","RAD54L","MCM6","RECQL4","MCM7","MCM4","MCM2","GINS1","RAD51","DNA2","HMGB2","BLM","HMGB3","DDX11","GINS4"]} {"pathway":"GO_TRANSCRIPTION_COUPLED_NUCLEOTIDE_EXCISION_REPAIR","pval":0.00143,"padj":0.08065,"ES":-0.92579,"NES":-1.66076,"nMoreExtreme":35,"size":73,"leadingEdge":["RFC3","RFC5","RFC4","PCNA","POLD2","LIG1"]} {"pathway":"GO_DNA_DEPENDENT_DNA_REPLICATION","pval":0.00018,"padj":0.01996,"ES":-0.83652,"NES":-1.66393,"nMoreExtreme":2,"size":142,"leadingEdge":["CCNE2","E2F8","MCM10","GINS2","CDC45","CDC6","TICRR","MCM6","MCM7","DSCC1","MCM4","CDT1","MCM2","FEN1","ORC1","POLE2","MCM5","EME1","CHTF18","TONSL","GINS1","POLQ","RFC3","RFC5","RFC4","RAD51","DNA2","ORC6","E2F7","MMS22L","WDHD1","POLA1","FBXO5","POLE","BLM","CENPS","MCM3","GINS3","FGFR1","CCNE1","DDX11","GINS4","PCNA","DONSON","ATAD5","CDC7"]} {"pathway":"GO_NUCLEAR_CHROMOSOME_SEGREGATION","pval":0.00017,"padj":0.01996,"ES":-0.80223,"NES":-1.67568,"nMoreExtreme":1,"size":219,"leadingEdge":["CCNE2","TOP2A","MEIKIN","CDC6","DSCC1","ESCO2","DMC1","KIF18B","CDT1","FEN1","NCAPG","CDCA5","ZWINT","PRC1","MAD2L1","NUF2","NUSAP1","NDC80","AURKB","NCAPH","BUB1B","CENPF","EME1","KIFC1","HASPIN","TTK","ESPL1","SPAG5","KIF14","KIF2C","KNL1","DLGAP5","SGO1","NEK2","KIF4A","FBXO5","CDCA8","BUB1","CDC20","NCAPD3","TRIP13","BLM","PLK1","SLF1","SMC4","KIF25","SMC2","CENPS","XRCC3","FAM83D","TACC3","DSN1","NCAPD2","CENPE","CCNE1","DDX11","RACGAP1","CENPQ","NCAPH2","KIF22"]} {"pathway":"GO_PROTEIN_N_LINKED_GLYCOSYLATION","pval":0.00084,"padj":0.05498,"ES":-0.93208,"NES":-1.67572,"nMoreExtreme":20,"size":74,"leadingEdge":["DERL3","MAN1C1","MGAT4A"]} {"pathway":"GO_DNA_PACKAGING","pval":0.00036,"padj":0.03034,"ES":-0.8841,"NES":-1.70472,"nMoreExtreme":6,"size":114,"leadingEdge":["TOP2A","HELLS","MCM2","CENPM","NCAPG","CDCA5","OIP5","CDK1","CENPU","CHAF1B","NCAPG2","NUSAP1","CENPK","NCAPH","HJURP","CENPI","ASF1B","CHAF1A","KNL1","CENPA","CENPP","HMGB2","NCAPD3","SMYD3","CENPH","SMC4","SMC2","CENPS","NCAPD2","CENPN","CENPQ","NCAPH2"]} {"pathway":"GO_DNA_REPLICATION","pval":0.0001,"padj":0.014,"ES":-0.80409,"NES":-1.71,"nMoreExtreme":0,"size":260,"leadingEdge":["CCNE2","E2F8","MCM10","GINS2","RRM2","CDC45","CDC6","PCLAF","CLSPN","TICRR","MCM6","RECQL4","MCM7","EXO1","DSCC1","MCM4","ESCO2","CDT1","MCM2","FEN1","CDK1","BRCA1","DTL","CCNA2","ORC1","CHAF1B","POLE2","MCM5","EME1","CHTF18","TONSL","GINS1","POLQ","RFC3","MCM8","RFC5","RFC4","RAD51","DNA2","ORC6","E2F7","MMS22L","WDHD1","CHAF1A","NFIA","POLA1","CHEK1","FBXO5","POLE","RRM1","BLM","CENPS","MCM3","GINS3","FGFR1","CCNE1","DDX11","GINS4","PCNA","DUT","DONSON","ATAD5","CDC7","ID3"]} {"pathway":"GO_MITOTIC_SISTER_CHROMATID_SEGREGATION","pval":0.00012,"padj":0.01492,"ES":-0.86228,"NES":-1.71517,"nMoreExtreme":1,"size":142,"leadingEdge":["CDC6","DSCC1","KIF18B","CDT1","NCAPG","CDCA5","ZWINT","PRC1","MAD2L1","NUF2","NUSAP1","NDC80","AURKB","NCAPH","BUB1B","CENPF","KIFC1","HASPIN","TTK","ESPL1","SPAG5","KIF14","KIF2C","DLGAP5","SGO1","NEK2","KIF4A","FBXO5","CDCA8","BUB1","CDC20","NCAPD3","TRIP13","PLK1","SLF1","SMC4","KIF25","SMC2","XRCC3","TACC3","DSN1","NCAPD2","CENPE","RACGAP1","NCAPH2","KIF22"]} {"pathway":"GO_MITOTIC_NUCLEAR_DIVISION","pval":0.00011,"padj":0.014,"ES":-0.81444,"NES":-1.73284,"nMoreExtreme":0,"size":262,"leadingEdge":["CCNE2","CD28","MYBL2","CDC6","DSCC1","KIF18B","CDT1","LRP5","NCAPG","CDCA5","ZWINT","PKMYT1","BIRC5","ANLN","PRC1","MKI67","CCNA2","KIF11","MAD2L1","NUF2","NUSAP1","NDC80","AURKB","NCAPH","CCNF","BUB1B","CENPF","KIFC1","HASPIN","CDC25C","TTK","ESPL1","SPAG5","INSR","KIF14","KIF2C","UBE2C","DLGAP5","SGO1","CCNB2","CHEK1","NEK2","TPX2","KIF4A","FBXO5","CDCA8","BUB1","CDC20","NCAPD3","TRIP13","PLK1","SLF1","SMC4","KIF25","SMC2","XRCC3","TACC3","DSN1","NCAPD2","CENPE","CCNE1","RCC1","RACGAP1","NCAPH2","BMP4","KIF22"]} {"pathway":"GO_NUCLEOSOME_ORGANIZATION","pval":0.00018,"padj":0.01996,"ES":-0.93085,"NES":-1.73441,"nMoreExtreme":3,"size":91,"leadingEdge":["MCM2","CENPM","OIP5","CENPU","CHAF1B","CENPK","HJURP","CENPI","ASF1B","CHAF1A","KNL1","CENPA","CENPP","HMGB2","SMYD3","CENPH","CENPS","CENPN","CENPQ"]} {"pathway":"GO_CHROMOSOME_SEGREGATION","pval":0.00011,"padj":0.0141,"ES":-0.81589,"NES":-1.74059,"nMoreExtreme":0,"size":271,"leadingEdge":["CCNE2","TOP2A","MEIKIN","SPC25","CDC6","DSCC1","ESCO2","DMC1","KIF18B","CDT1","FEN1","NCAPG","CDCA5","ZWINT","OIP5","BIRC5","BRCA1","PRC1","MKI67","MAD2L1","NUF2","NUSAP1","NDC80","AURKB","NCAPH","BUB1B","CENPF","HJURP","EME1","SKA3","KIFC1","HASPIN","TTK","ESPL1","SPAG5","SKA1","KIF14","KIF2C","KNL1","DLGAP5","SGO1","NEK2","KIF4A","FBXO5","CDCA8","BUB1","CDC20","NCAPD3","TRIP13","BLM","PLK1","SLF1","SMC4","KIF25","SMC2","CENPS","XRCC3","FAM83D","TACC3","DSN1","NCAPD2","CENPE","CCNE1","DDX11","CENPN","RCC1","RACGAP1","CENPQ","NCAPH2","KIF22"]} {"pathway":"GO_MRNA_EXPORT_FROM_NUCLEUS","pval":0.00015,"padj":0.01728,"ES":-0.91644,"NES":-1.74646,"nMoreExtreme":2,"size":106,"leadingEdge":["NXF3","NDC1"]} {"pathway":"GO_MRNA_3_END_PROCESSING","pval":0.00014,"padj":0.0167,"ES":-0.93015,"NES":-1.74819,"nMoreExtreme":2,"size":96,"leadingEdge":["LSM11"]} {"pathway":"GO_ATP_SYNTHESIS_COUPLED_ELECTRON_TRANSPORT","pval":0.00004,"padj":0.00761,"ES":-0.98218,"NES":-1.79004,"nMoreExtreme":0,"size":80,"leadingEdge":["CDK1"]} {"pathway":"GO_OXIDATIVE_PHOSPHORYLATION","pval":0.0001,"padj":0.014,"ES":-0.92435,"NES":-1.79007,"nMoreExtreme":1,"size":117,"leadingEdge":["CDK1","MSH2"]} {"pathway":"GO_CELL_DIVISION","pval":0.00031,"padj":0.02801,"ES":-0.80457,"NES":-1.8002,"nMoreExtreme":0,"size":519,"leadingEdge":["LBH","CCNE2","E2F8","TOP2A","SPC25","TAL1","CDC25A","CDC6","CDCA3","HELLS","KIF18B","CDT1","ERCC6L","SPC24","NCAPG","CDCA5","ZWINT","OIP5","CDK1","BIRC5","ANLN","PRC1","CCNA2","KIF11","MAD2L1","NCAPG2","OSM","NUF2","NUSAP1","NDC80","AURKB","NCAPH","STMN1","CCNF","SOX17","BUB1B","DLL1","CENPF","WEE1","SKA3","KIFC1","CDC25C","HTR2B","ESPL1","SPAG5","PDGFC","SKA1","CIT","KIF14","PIMREG","ORC6","E2F7","KIF2C","ASPM","KNL1","UBE2C","CENPA","SGO1","CCNB2","NEK2","TPX2","KIF4A","FBXO5","CDCA8","BUB1","CDC20","NCAPD3","PPBP","KIF20A","BLM","CDCA2","PLK1","SMC4","CEP55","SMC2","CENPS","CABLES1","FAM83D","TACC3","DSN1","CAT","FZD7","FGFR1","NCAPD2","CENPE","CCNE1","RCC1","RACGAP1"]} {"pathway":"GO_RNA_EXPORT_FROM_NUCLEUS","pval":0.00006,"padj":0.00977,"ES":-0.91632,"NES":-1.80436,"nMoreExtreme":0,"size":132,"leadingEdge":["NXF3","NDC1"]} {"pathway":"GO_DNA_CONFORMATION_CHANGE","pval":0.00008,"padj":0.01171,"ES":-0.87814,"NES":-1.82509,"nMoreExtreme":0,"size":208,"leadingEdge":["TOP2A","GINS2","CDC45","RAD54L","MCM6","RECQL4","MCM7","HELLS","MCM4","MCM2","CENPM","NCAPG","CDCA5","OIP5","CDK1","CENPU","CHAF1B","NCAPG2","NUSAP1","CENPK","NCAPH","HJURP","GINS1","CENPI","RAD51","DNA2","ASF1B","CHAF1A","KNL1","CENPA","CENPP","HMGB2","NCAPD3","SMYD3","BLM","CENPH","HMGB3","SMC4","SMC2","CENPS","NCAPD2","DDX11","GINS4","CENPN","CENPQ","NCAPH2"]} {"pathway":"GO_PROTEIN_DNA_COMPLEX_SUBUNIT_ORGANIZATION","pval":0.00007,"padj":0.01098,"ES":-0.92167,"NES":-1.89303,"nMoreExtreme":0,"size":186,"leadingEdge":["CDC45","HELLS","DMC1","CDT1","MCM2","CENPM","OIP5","CENPU","CHAF1B","CENPK","CENPF","HJURP","CENPI","RAD51","ASF1B","CHAF1A","KNL1","CENPA","CENPP","HMGB2","SMYD3","CENPH","CENPS","CENPE","CENPN","CENPQ"]}