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atac_dnase_chip_example

  • Analysis of ATAC-seq, DNase-seq and ChIP-seq data from K562 cells. All data comes from ENCODE. Only chromosome 1 is analysed in this example.
  • Code to reproduce.

atac_dnase_example

Session Information

utils::sessionInfo()
## R version 4.4.2 (2024-10-31)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 24.04.1 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.26.so;  LAPACK version 3.12.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=C              
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Etc/UTC
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats     graphics  grDevices utils     datasets  methods   base     
## 
## other attached packages:
## [1] EpiCompare_1.11.0 BiocStyle_2.35.0 
## 
## loaded via a namespace (and not attached):
##   [1] RColorBrewer_1.1-3                     
##   [2] sys_3.4.3                              
##   [3] jsonlite_1.8.9                         
##   [4] magrittr_2.0.3                         
##   [5] ggtangle_0.0.4                         
##   [6] GenomicFeatures_1.59.1                 
##   [7] farver_2.1.2                           
##   [8] rmarkdown_2.29                         
##   [9] fs_1.6.5                               
##  [10] BiocIO_1.17.1                          
##  [11] zlibbioc_1.52.0                        
##  [12] vctrs_0.6.5                            
##  [13] memoise_2.0.1                          
##  [14] Rsamtools_2.23.1                       
##  [15] b64_0.1.3                              
##  [16] RCurl_1.98-1.16                        
##  [17] ggtree_3.15.0                          
##  [18] htmltools_0.5.8.1                      
##  [19] S4Arrays_1.7.1                         
##  [20] TxDb.Hsapiens.UCSC.hg19.knownGene_3.2.2
##  [21] plotrix_3.8-4                          
##  [22] AnnotationHub_3.15.0                   
##  [23] curl_6.0.1                             
##  [24] SparseArray_1.7.2                      
##  [25] gridGraphics_0.5-1                     
##  [26] sass_0.4.9                             
##  [27] KernSmooth_2.23-24                     
##  [28] bslib_0.8.0                            
##  [29] htmlwidgets_1.6.4                      
##  [30] plyr_1.8.9                             
##  [31] lubridate_1.9.3                        
##  [32] plotly_4.10.4                          
##  [33] impute_1.81.0                          
##  [34] cachem_1.1.0                           
##  [35] buildtools_1.0.0                       
##  [36] GenomicAlignments_1.43.0               
##  [37] igraph_2.1.1                           
##  [38] mime_0.12                              
##  [39] downloadthis_0.4.1                     
##  [40] lifecycle_1.0.4                        
##  [41] pkgconfig_2.0.3                        
##  [42] Matrix_1.7-1                           
##  [43] R6_2.5.1                               
##  [44] fastmap_1.2.0                          
##  [45] GenomeInfoDbData_1.2.13                
##  [46] MatrixGenerics_1.19.0                  
##  [47] digest_0.6.37                          
##  [48] aplot_0.2.3                            
##  [49] enrichplot_1.27.1                      
##  [50] colorspace_2.1-1                       
##  [51] patchwork_1.3.0                        
##  [52] AnnotationDbi_1.69.0                   
##  [53] S4Vectors_0.45.2                       
##  [54] GenomicRanges_1.59.1                   
##  [55] RSQLite_2.3.8                          
##  [56] labeling_0.4.3                         
##  [57] bsplus_0.1.4                           
##  [58] filelock_1.0.3                         
##  [59] timechange_0.3.0                       
##  [60] fansi_1.0.6                            
##  [61] httr_1.4.7                             
##  [62] abind_1.4-8                            
##  [63] compiler_4.4.2                         
##  [64] withr_3.0.2                            
##  [65] bit64_4.5.2                            
##  [66] BiocParallel_1.41.0                    
##  [67] DBI_1.2.3                              
##  [68] gplots_3.2.0                           
##  [69] R.utils_2.12.3                         
##  [70] ChIPseeker_1.43.0                      
##  [71] rappdirs_0.3.3                         
##  [72] DelayedArray_0.33.2                    
##  [73] rjson_0.2.23                           
##  [74] caTools_1.18.3                         
##  [75] gtools_3.9.5                           
##  [76] tools_4.4.2                            
##  [77] ape_5.8                                
##  [78] R.oo_1.27.0                            
##  [79] glue_1.8.0                             
##  [80] restfulr_0.0.15                        
##  [81] nlme_3.1-166                           
##  [82] GOSemSim_2.33.0                        
##  [83] grid_4.4.2                             
##  [84] gridBase_0.4-7                         
##  [85] reshape2_1.4.4                         
##  [86] fgsea_1.33.0                           
##  [87] generics_0.1.3                         
##  [88] BSgenome_1.75.0                        
##  [89] gtable_0.3.6                           
##  [90] tzdb_0.4.0                             
##  [91] R.methodsS3_1.8.2                      
##  [92] seqPattern_1.39.0                      
##  [93] tidyr_1.3.1                            
##  [94] hms_1.1.3                              
##  [95] data.table_1.16.2                      
##  [96] utf8_1.2.4                             
##  [97] XVector_0.47.0                         
##  [98] BiocGenerics_0.53.3                    
##  [99] ggrepel_0.9.6                          
## [100] BiocVersion_3.21.1                     
## [101] pillar_1.9.0                           
## [102] stringr_1.5.1                          
## [103] yulab.utils_0.1.8                      
## [104] splines_4.4.2                          
## [105] dplyr_1.1.4                            
## [106] treeio_1.31.0                          
## [107] BiocFileCache_2.15.0                   
## [108] lattice_0.22-6                         
## [109] rtracklayer_1.67.0                     
## [110] bit_4.5.0                              
## [111] tidyselect_1.2.1                       
## [112] GO.db_3.20.0                           
## [113] maketools_1.3.1                        
## [114] Biostrings_2.75.1                      
## [115] knitr_1.49                             
## [116] IRanges_2.41.1                         
## [117] SummarizedExperiment_1.37.0            
## [118] stats4_4.4.2                           
## [119] xfun_0.49                              
## [120] Biobase_2.67.0                         
## [121] matrixStats_1.4.1                      
## [122] stringi_1.8.4                          
## [123] UCSC.utils_1.3.0                       
## [124] lazyeval_0.2.2                         
## [125] ggfun_0.1.7                            
## [126] yaml_2.3.10                            
## [127] boot_1.3-31                            
## [128] evaluate_1.0.1                         
## [129] codetools_0.2-20                       
## [130] tibble_3.2.1                           
## [131] qvalue_2.39.0                          
## [132] BiocManager_1.30.25                    
## [133] ggplotify_0.1.2                        
## [134] cli_3.6.3                              
## [135] munsell_0.5.1                          
## [136] jquerylib_0.1.4                        
## [137] Rcpp_1.0.13-1                          
## [138] GenomeInfoDb_1.43.2                    
## [139] dbplyr_2.5.0                           
## [140] png_0.1-8                              
## [141] XML_3.99-0.17                          
## [142] parallel_4.4.2                         
## [143] readr_2.1.5                            
## [144] ggplot2_3.5.1                          
## [145] blob_1.2.4                             
## [146] DOSE_4.1.0                             
## [147] bitops_1.0-9                           
## [148] viridisLite_0.4.2                      
## [149] tidytree_0.4.6                         
## [150] scales_1.3.0                           
## [151] genomation_1.39.0                      
## [152] purrr_1.0.2                            
## [153] crayon_1.5.3                           
## [154] rlang_1.1.4                            
## [155] cowplot_1.1.3                          
## [156] fastmatch_1.1-4                        
## [157] KEGGREST_1.47.0