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atac_dnase_chip_example

  • Analysis of ATAC-seq, DNase-seq and ChIP-seq data from K562 cells. All data comes from ENCODE. Only chromosome 1 is analysed in this example.
  • Code to reproduce.

atac_dnase_example

Session Information

utils::sessionInfo()
## R version 4.6.1 (2026-06-24)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 26.04.1 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.32.so;  LAPACK version 3.12.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Etc/UTC
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats     graphics  grDevices utils     datasets  methods   base     
## 
## other attached packages:
## [1] EpiCompare_1.17.0 BiocStyle_2.41.0 
## 
## loaded via a namespace (and not attached):
##   [1] RColorBrewer_1.1-3                      
##   [2] sys_3.4.3                               
##   [3] jsonlite_2.0.0                          
##   [4] tidydr_0.0.7                            
##   [5] magrittr_2.0.5                          
##   [6] ggtangle_0.1.3                          
##   [7] GenomicFeatures_1.65.0                  
##   [8] farver_2.1.2                            
##   [9] rmarkdown_2.32                          
##  [10] fs_2.1.0                                
##  [11] BiocIO_1.23.3                           
##  [12] vctrs_0.7.3                             
##  [13] memoise_2.0.1                           
##  [14] Rsamtools_2.29.0                        
##  [15] RCurl_1.98-1.20                         
##  [16] base64enc_0.1-6                         
##  [17] ggtree_4.3.0                            
##  [18] htmltools_0.5.9                         
##  [19] TxDb.Hsapiens.UCSC.hg19.knownGene_3.22.1
##  [20] BiocBaseUtils_1.15.1                    
##  [21] plotrix_3.8-14                          
##  [22] AnnotationHub_4.3.2                     
##  [23] curl_8.0.0                              
##  [24] gridGraphics_0.5-1                      
##  [25] sass_0.4.10                             
##  [26] KernSmooth_2.23-27                      
##  [27] bslib_0.12.0                            
##  [28] htmlwidgets_1.6.4                       
##  [29] plyr_1.8.9                              
##  [30] httr2_1.3.0                             
##  [31] lubridate_1.9.5                         
##  [32] plotly_4.12.1                           
##  [33] impute_1.87.0                           
##  [34] cachem_1.1.0                            
##  [35] buildtools_1.0.0                        
##  [36] GenomicAlignments_1.49.2                
##  [37] igraph_2.3.4                            
##  [38] mime_0.13                               
##  [39] downloadthis_0.5.0                      
##  [40] lifecycle_1.0.5                         
##  [41] pkgconfig_2.0.3                         
##  [42] Matrix_1.7-6                            
##  [43] R6_2.6.1                                
##  [44] fastmap_1.2.0                           
##  [45] digest_0.6.39                           
##  [46] aplot_0.3.2                             
##  [47] enrichplot_1.99.8                       
##  [48] ggnewscale_0.5.2                        
##  [49] patchwork_1.3.2                         
##  [50] AnnotationDbi_1.75.2                    
##  [51] S4Vectors_0.51.10                       
##  [52] GenomicRanges_1.65.4                    
##  [53] RSQLite_3.53.3                          
##  [54] labeling_0.4.3                          
##  [55] bsplus_0.1.5                            
##  [56] filelock_1.0.3                          
##  [57] timechange_0.4.0                        
##  [58] httr_1.4.9                              
##  [59] polyclip_1.10-7                         
##  [60] compiler_4.6.1                          
##  [61] withr_3.0.3                             
##  [62] bit64_4.8.6                             
##  [63] fontquiver_0.2.1                        
##  [64] S7_0.2.2                                
##  [65] BiocParallel_1.47.0                     
##  [66] DBI_1.3.0                               
##  [67] gplots_3.3.0                            
##  [68] ggforce_0.5.0                           
##  [69] MASS_7.3-66                             
##  [70] ChIPseeker_1.49.3                       
##  [71] rappdirs_0.3.4                          
##  [72] rjson_0.2.23                            
##  [73] caTools_1.18.4                          
##  [74] gtools_3.9.5                            
##  [75] tools_4.6.1                             
##  [76] otel_0.2.0                              
##  [77] ape_5.8-1                               
##  [78] scatterpie_0.2.6                        
##  [79] glue_1.8.1                              
##  [80] restfulr_0.0.17                         
##  [81] nlme_3.1-171                            
##  [82] GOSemSim_2.39.4                         
##  [83] grid_4.6.1                              
##  [84] gridBase_0.4-7                          
##  [85] cluster_2.1.8.3                         
##  [86] reshape2_1.4.5                          
##  [87] generics_0.1.4                          
##  [88] BSgenome_1.81.1                         
##  [89] gtable_0.3.6                            
##  [90] tzdb_0.5.0                              
##  [91] seqPattern_1.45.0                       
##  [92] tidyr_1.3.2                             
##  [93] hms_1.1.4                               
##  [94] data.table_1.18.6.1                     
##  [95] XVector_0.53.0                          
##  [96] BiocGenerics_0.59.12                    
##  [97] ggrepel_0.9.8                           
##  [98] BiocVersion_3.24.0                      
##  [99] pillar_1.11.1                           
## [100] stringr_1.6.0                           
## [101] yulab.utils_0.2.5                       
## [102] dplyr_1.2.1                             
## [103] tweenr_2.0.3                            
## [104] BiocFileCache_3.3.0                     
## [105] treeio_1.37.1                           
## [106] lattice_0.23-1                          
## [107] rtracklayer_1.73.0                      
## [108] bit_4.6.0                               
## [109] tidyselect_1.2.1                        
## [110] fontLiberation_0.1.0                    
## [111] GO.db_3.23.1                            
## [112] maketools_1.3.2                         
## [113] Biostrings_2.81.9                       
## [114] knitr_1.52                              
## [115] fontBitstreamVera_0.1.1                 
## [116] IRanges_2.47.5                          
## [117] Seqinfo_1.3.2                           
## [118] stats4_4.6.1                            
## [119] xfun_0.61                               
## [120] Biobase_2.73.2                          
## [121] matrixStats_1.5.0                       
## [122] stringi_1.8.9                           
## [123] UCSC.utils_1.9.0                        
## [124] lazyeval_0.2.3                          
## [125] ggfun_0.2.2                             
## [126] yaml_2.3.12                             
## [127] boot_1.3-32                             
## [128] evaluate_1.0.5                          
## [129] codetools_0.2-20                        
## [130] cigarillo_1.3.1                         
## [131] gdtools_0.5.1                           
## [132] tibble_3.3.1                            
## [133] BiocManager_1.30.27                     
## [134] ggplotify_0.1.3                         
## [135] cli_3.6.6                               
## [136] systemfonts_1.3.2                       
## [137] jquerylib_0.1.4                         
## [138] Rcpp_1.1.2                              
## [139] GenomeInfoDb_1.49.1                     
## [140] dbplyr_2.6.0                            
## [141] png_0.1-9                               
## [142] XML_3.99-0.25                           
## [143] parallel_4.6.1                          
## [144] readr_2.2.0                             
## [145] ggplot2_4.0.3                           
## [146] blob_1.3.0                              
## [147] DOSE_4.7.3                              
## [148] bitops_1.1-0                            
## [149] viridisLite_0.4.3                       
## [150] tidytree_0.4.8                          
## [151] ggiraph_0.9.6                           
## [152] enrichit_0.2.6                          
## [153] scales_1.4.0                            
## [154] genomation_1.45.0                       
## [155] purrr_1.2.2                             
## [156] crayon_1.5.3                            
## [157] rlang_1.3.0                             
## [158] KEGGREST_1.53.6