Package: DominoEffect Type: Package Title: Identification and Annotation of Protein Hotspot Residues Version: 1.33.0 Author: Marija Buljan and Peter Blattmann Maintainer: Marija Buljan , Peter Blattmann Description: The functions support identification and annotation of hotspot residues in proteins. These are individual amino acids that accumulate mutations at a much higher rate than their surrounding regions. License: GPL (>= 3) Encoding: UTF-8 LazyData: true Depends: R(>= 3.5) Imports: biomaRt, data.table, utils, stats, Biostrings, pwalign, SummarizedExperiment, VariantAnnotation, AnnotationDbi, Seqinfo, IRanges, GenomicRanges, methods Suggests: knitr, testthat, rmarkdown RoxygenNote: 6.0.1 VignetteBuilder: knitr biocViews: Software, SomaticMutation, Proteomics, SequenceMatching, Alignment NeedsCompilation: no Config/pak/sysreqs: make libbz2-dev libicu-dev liblzma-dev libpng-dev libxml2-dev libssl-dev xz-utils zlib1g-dev Repository: https://bioc.r-universe.dev Date/Publication: 2026-04-28 12:47:19 UTC RemoteUrl: https://github.com/bioc/DominoEffect RemoteRef: HEAD RemoteSha: cb54b0bac046a05e92795d293c1f1ffe3d9bb229 Packaged: 2026-07-04 13:51:31 UTC; root