Version: 0.99 Category: NEW FEATURES Text: Initial release. Version: 0.99-1 Text: Fixed a bug in newSeqCountSet in dealing with the input experimental designs. Version: 0.99-1 Text: Fixed a bug in computing local FDR. Version: 0.99-1 Text: Add options to model the relationship between dispersion and mean expression. Version: 1.2.0-1 Text: Fixed a bug in computing local FDR. Version: 1.2.0-1 Text: Change the way to deal with genes with all 0 counts. Now the FDRs for these genes are assigned as 0. Version: 1.6.0 Text: Implemented methods for detecting differentially methylated loci (DML). Version: 1.7.0 Text: Added functionalities for multiple factor experimental design. Currently edgeR functions are used for glm fitting and hypothesis testing. DSS only provide functions for dispersion estimation. Version: 2.0.0 Text: Implemented methods for detecting differentially methylated regions (DMR). Version: 2.0.0 Text: Modified the algorithm for computing variances with smoothing. Version: 2.0.0 Text: Add function to detect DML for general experimental design. Version: 2.0.0 Text: Add function to detect DML for general experimental design. Version: 2.5.0 Text: Modify the parallel computing part in DML testing. We now use the 'mcapply' function in 'parallel' package to implement parallelization. Note that older version of DSS (<2.4x) used the 'bplapply' function in 'BiocParallel' package. However, that function somehow has significantly reduced performance in the new release (>1.25), so we switched to mcapply. A drawback is that the progress bar cannot be displayed under the paralelle computing setting.