NEWS

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DRIMSeq 1.3.3

Additionally

• i) Removing max_features argument from dmFilter. ii) Keeping only the grid approach for estimating tagwise dispersion. iii) Allow to use only a subset of genes (disp_subset parameter) in common dispersion estimation to speed up the calculations; if disp_subset < 1, use set.seed() to make the analysis reproducible. iv) Always use tagwise dispersion for fitting full and null models. v) In one group fitting, return NA for tags having the last feature with zero counts in all samples. We always use the q-th feature as a denominator in logit calculation. In such a case all the logits are anyways Inf. vi) Use plotPValues instead of plotTest vii) Use 'prop' instead of 'pi' and 'disp' instead of 'gamma0'. viii) Use only 'constrOptim' (old 'constrOptimG') to estimate proportions and 'optim' to estimate coefficients in the regression model. ix) Use plotProportions instead of plotFit. x) No 'out_dir' parameter in plotting functions. All plotting functions return a ggplot object. xi) Use term "precision" instead of "dispersion" as in DRIMSeq we directly estimate the precision parameter. Dispersion can be calculated with formula: dispersion = 1 / (1 + precision).

DRIMSeq 1.3.2

DRIMSeq 1.3.1

DRIMSeq 1.1.4

DRIMSeq 1.1.3

• i) The level of moderation is calculated automatically. ii) Permutation approach to adjust p-values in sQTL analyses.

DRIMSeq 1.1.2

DRIMSeq 0.99.0