Package: CytoGLMM
Type: Package
Title: Conditional Differential Analysis for Flow and Mass Cytometry
        Experiments
Version: 1.21.0
Authors@R: c(
    person("Christof", "Seiler", , "christof.seiler@maastrichtuniversity.nl", 
    role = c("aut", "cre"), 
    comment = c(ORCID = "0000-0001-8802-3642"))
    )
Description: The CytoGLMM R package implements two multiple regression
        strategies: A bootstrapped generalized linear model (GLM) and a
        generalized linear mixed model (GLMM). Most current data
        analysis tools compare expressions across many computationally
        discovered cell types. CytoGLMM focuses on just one cell type.
        Our narrower field of application allows us to define a more
        specific statistical model with easier to control statistical
        guarantees. As a result, CytoGLMM finds differential proteins
        in flow and mass cytometry data while reducing biases arising
        from marker correlations and safeguarding against false
        discoveries induced by patient heterogeneity.
License: LGPL-3
URL: https://christofseiler.github.io/CytoGLMM,
        https://github.com/ChristofSeiler/CytoGLMM
BugReports: https://github.com/ChristofSeiler/CytoGLMM/issues
Encoding: UTF-8
Imports: stats, methods, BiocParallel, RColorBrewer, cowplot,
        doParallel, dplyr, factoextra, flexmix, ggplot2, magrittr,
        mbest, pheatmap, stringr, strucchange, tibble, ggrepel, MASS,
        logging, Matrix, tidyr, caret, rlang, grDevices
Suggests: knitr, rmarkdown, testthat, BiocStyle
VignetteBuilder: knitr
RoxygenNote: 7.3.2
biocViews: FlowCytometry, Proteomics, SingleCell, CellBasedAssays,
        CellBiology, ImmunoOncology, Regression, StatisticalMethod,
        Software
Config/pak/sysreqs: cmake libfreetype6-dev make libicu-dev libjpeg-dev
        libpng-dev libuv1-dev libxml2-dev libssl-dev zlib1g-dev
Repository: https://bioc.r-universe.dev
Date/Publication: 2026-04-28 12:55:33 UTC
RemoteUrl: https://github.com/bioc/CytoGLMM
RemoteRef: HEAD
RemoteSha: b457ea4ed5f7b4c497c678aed40162042da82062
NeedsCompilation: no
Packaged: 2026-07-05 01:45:46 UTC; root
Author: Christof Seiler [aut, cre] (ORCID:
    <https://orcid.org/0000-0001-8802-3642>)
Maintainer: Christof Seiler <christof.seiler@maastrichtuniversity.nl>