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# CITATION file created with {cffr} R package
# See also: https://docs.ropensci.org/cffr/
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cff-version: 1.2.0
message: 'To cite package "ClonalSim" in publications use:'
type: software
license: MIT
title: 'ClonalSim: Simulation of Tumor Clonal Evolution with Realistic Sequencing
  Noise'
version: 1.1.0
doi: 10.32614/CRAN.package.ClonalSim
abstract: ClonalSim generates realistic mutational profiles of tumor samples with
  hierarchical clonal structure. It simulates founder, shared, and private mutations
  with biologically realistic noise models including intra-tumor heterogeneity (Beta
  distribution) and technical sequencing noise (negative binomial depth variation,
  binomial read sampling, base errors). The package is designed for benchmarking variant
  callers, testing clonal deconvolution algorithms, and teaching tumor heterogeneity
  concepts.
authors:
- family-names: Bucci
  given-names: Gabriele
  email: bucci.g@gmail.com
  orcid: https://orcid.org/0000-0001-9838-7204
repository: https://bioc.r-universe.dev
repository-code: https://github.com/gbucci/ClonalSim
commit: 6048f4bf99d8d4830dcc714f9cf298ed72c22269
url: https://github.com/gbucci/ClonalSim
date-released: '2026-04-28'
contact:
- family-names: Bucci
  given-names: Gabriele
  email: bucci.g@gmail.com
  orcid: https://orcid.org/0000-0001-9838-7204