NEWS

---

CatsCradle 1.3.3

• Example data ligandReceptorResults.rda saved in compressed format.

CatsCradle 1.3.2

• Function getLigandReceptorPairsInPanel rewritten for faster runtime.
• Analytical option to calculate pvalues added to computeNeighbourEnrichment. This has a faster runtime.
• Function performLigandReceptorAnalysis rewritten for faster runtime by making use of sparse matrices.
• Analytical option to calculate pvalues added to performLigandReceptorAnalysis. This has a faster runtime.
• Function plotLRDotplot added to visualise ligand-receptor interactions returned by performLigandReceptorAnalysis.

CatsCradle 1.3.1

• smallXenium@images$fov@misc = list() field added to smallXenium example data for compatability with Seurat updates.

CatsCradle 1.1.2

• Function getSubsetComponents added. This is designed to dectect the components of a gene subset in the case where median complement distance detects clustering.
• Function edgeLengthsAndCellTypePairs rewritten for faster runtime.

CatsCradle 1.1.1

• Default behaviour of nbhdsAsEdgesToNbhdsAsList changed to exclude self. This fixes a bug leading to inflated values of MoransI.

CatsCradle 0.99.10

• We have now broken out our code into files pertaining to different areas of functionality.
• We have improved functionality for handling SingleCellExperiment and SpatialExperiment objects.
• CatsCradle is currently under review at Bioconductor. Watch this space.