Package: COTAN
Type: Package
Title: COexpression Tables ANalysis
Version: 2.13.1
Authors@R: c(
  person("Galfrè", "Silvia Giulia",email = "silvia.galfre@di.unipi.it", role=c("aut","cre"),comment = c(ORCID = "0000-0002-2770-0344")),
  person("Morandin","Francesco", email = "francesco.morandin@unipr.it", role = "aut",comment = c(ORCID = "0000-0002-2022-2300")),
  person("Fantozzi", "Marco", email = "marco.fantozzi@gmail.com", role = "aut", comment = c(ORCID = "0000-0002-0708-5495")),
  person("Pietrosanto","Marco", role = "aut",comment = c(ORCID = "0000-0001-5129-6065")),
  person("Puttini","Daniel", role = "aut", comment = c(ORCID = "0009-0006-8401-9949")),
  person("Priami","Corrado", role = "aut", comment = c(ORCID = "0000-0002-3261-6235")),
  person("Cremisi","Federico", role = "aut",comment = c(ORCID = "0000-0003-4925-2703")),
  person("Helmer-Citterich","Manuela", role = "aut",comment = c(ORCID = "0000-0001-9530-7504"))
  )
Description: Statistical and computational method to analyze the
        co-expression of gene pairs at single cell level. It provides
        the foundation for single-cell gene interactome analysis. The
        basic idea is studying the zero UMI counts' distribution
        instead of focusing on positive counts; this is done with a
        generalized contingency tables framework. COTAN can effectively
        assess the correlated or anti-correlated expression of gene
        pairs. It provides a numerical index related to the correlation
        and an approximate p-value for the associated independence
        test. COTAN can also evaluate whether single genes are
        differentially expressed, scoring them with a newly defined
        global differentiation index. Moreover, this approach provides
        ways to plot and cluster genes according to their co-expression
        pattern with other genes, effectively helping the study of gene
        interactions and becoming a new tool to identify cell-identity
        marker genes.
URL: https://github.com/seriph78/COTAN
BugReports: https://github.com/seriph78/COTAN/issues
Depends: R (>= 4.3)
License: GPL-3
Encoding: UTF-8
Roxygen: list(markdown = TRUE)
Imports: stats, methods, grDevices, Matrix, ggplot2, ggrepel, ggdist,
        ggthemes, graphics, parallel, parallelly, tibble, tidyr, dplyr,
        BiocSingular, parallelDist, ComplexHeatmap, BiocStyle,
        circlize, grid, scales, RColorBrewer, utils, rlang, Rfast,
        stringr, Seurat, dendextend, zeallot, conflicted, assertthat,
        R.utils, withr, SummarizedExperiment, SingleCellExperiment,
        proxy, RSpectra, GEOquery
Suggests: testthat (>= 3.2.0), proto, spelling, knitr, ragg, Cairo,
        data.table, gsubfn, tidyverse, rmarkdown, htmlwidgets, MASS,
        Rtsne, plotly, cowplot, qpdf, sf, torch, S4Vectors
Config/testthat/edition: 3
Language: en-US
biocViews: SystemsBiology, Transcriptomics, GeneExpression, SingleCell,
        DifferentialExpression, Clustering, GPU
VignetteBuilder: knitr
LazyData: false
Config/roxygen2/version: 8.0.0
Config/pak/sysreqs: cmake libglpk-dev make libicu-dev libpng-dev
        libuv1-dev libxml2-dev libssl-dev perl python3 libx11-dev
        zlib1g-dev
Repository: https://bioc.r-universe.dev
Date/Publication: 2026-05-20 13:05:30 UTC
RemoteUrl: https://github.com/bioc/COTAN
RemoteRef: HEAD
RemoteSha: c968e6997af0dbcd408041c4a7c9faf24702d680
NeedsCompilation: no
Packaged: 2026-06-19 07:11:28 UTC; root
Author: Galfrè Silvia Giulia [aut, cre] (ORCID:
    <https://orcid.org/0000-0002-2770-0344>),
  Morandin Francesco [aut] (ORCID:
    <https://orcid.org/0000-0002-2022-2300>),
  Fantozzi Marco [aut] (ORCID: <https://orcid.org/0000-0002-0708-5495>),
  Pietrosanto Marco [aut] (ORCID:
    <https://orcid.org/0000-0001-5129-6065>),
  Puttini Daniel [aut] (ORCID: <https://orcid.org/0009-0006-8401-9949>),
  Priami Corrado [aut] (ORCID: <https://orcid.org/0000-0002-3261-6235>),
  Cremisi Federico [aut] (ORCID: <https://orcid.org/0000-0003-4925-2703>),
  Helmer-Citterich Manuela [aut] (ORCID:
    <https://orcid.org/0000-0001-9530-7504>)
Maintainer: Galfrè Silvia Giulia <silvia.galfre@di.unipi.it>