Changes in version 0.99.0 New features - Initial Bioconductor submission. - Implements prior-informed latent variable decomposition for gene expression. - Supports file-backed matrices (bigstatsr::FBM) for large datasets. - Added CPM, z-score, and filtering functions for preprocessing. - Projection of new datasets into pre-trained models. - Vignettes with example workflows and detailed documentation. Improvements - Optimized in-place operations for large matrices. - Added cross-validation utilities and adaptive sparsity support. - Roxygen2 documentation for all exported functions. Bug fixes - Fixed edge case in CPM normalization for zero-count columns. - Corrected NA handling in preprocessing.