Package: CHRONOS Version: 1.41.0 Date: 2020-09-05 Title: CHRONOS: A time-varying method for microRNA-mediated sub-pathway enrichment analysis Author: Aristidis G. Vrahatis, Konstantina Dimitrakopoulou, Panos Balomenos Maintainer: Panos Balomenos Description: A package used for efficient unraveling of the inherent dynamic properties of pathways. MicroRNA-mediated subpathway topologies are extracted and evaluated by exploiting the temporal transition and the fold change activity of the linked genes/microRNAs. Depends: R (>= 3.5) SystemRequirements: Java version >= 1.7, Pandoc License: GPL-2 NeedsCompilation: no LazyLoad: yes Imports: XML, RCurl, RBGL, parallel, foreach, doParallel, openxlsx, igraph, circlize, graph, stats, utils, grDevices, graphics, methods, biomaRt, rJava Suggests: RUnit, BiocGenerics, knitr, rmarkdown VignetteBuilder: knitr biocViews: SystemsBiology, GraphAndNetwork, Pathways, KEGG Config/pak/sysreqs: libglpk-dev make default-jdk libicu-dev libpng-dev libxml2-dev libssl-dev zlib1g-dev Repository: https://bioc.r-universe.dev Date/Publication: 2026-04-28 12:43:29 UTC RemoteUrl: https://github.com/bioc/CHRONOS RemoteRef: HEAD RemoteSha: 4da19ef004d67c83f6a158327dbf29504de7c416 Packaged: 2026-07-05 00:13:14 UTC; root