Package: BOBaFIT Type: Package Title: Refitting diploid region profiles using a clustering procedure Version: 1.17.0 Authors@R: c(person("Andrea", "Poletti", email="andrea.poletti5@gmail.com", role=c("aut")), person("Gaia", "Mazzocchetti", email="bioinformatic.seragnoli@gmail.com", role=c("aut", "cre")), person("Vincenza", "Solli", email="vincenza.solli2@unibo.it", role=c("aut"))) Description: This package provides a method to refit and correct the diploid region in copy number profiles. It uses a clustering algorithm to identify pathology-specific normal (diploid) chromosomes and then use their copy number signal to refit the whole profile. The package is composed by three functions: DRrefit (the main function), ComputeNormalChromosome and PlotCluster. License: GPL (>= 3) Encoding: UTF-8 LazyData: true RoxygenNote: 7.1.2 URL: https://github.com/andrea-poletti-unibo/BOBaFIT BugReports: https://github.com/andrea-poletti-unibo/BOBaFIT/issues Imports: dplyr, NbClust, ggplot2, ggbio, grDevices, stats, tidyr, GenomicRanges, ggforce, stringr, plyranges, methods, utils, magrittr Suggests: rmarkdown, markdown, BiocStyle, knitr, testthat (>= 3.0.0), utils, testthat Config/testthat/edition: 3 biocViews: CopyNumberVariation, Clustering, Visualization, Normalization, Software Depends: R (>= 2.10) VignetteBuilder: knitr Config/pak/sysreqs: cmake libfontconfig1-dev libfreetype6-dev make libbz2-dev libicu-dev liblzma-dev libpng-dev libuv1-dev libxml2-dev libssl-dev xz-utils zlib1g-dev Repository: https://bioc.r-universe.dev Date/Publication: 2026-04-28 12:57:38 UTC RemoteUrl: https://github.com/bioc/BOBaFIT RemoteRef: HEAD RemoteSha: 267dba81353de238dccd3457a21db41f6224af95 NeedsCompilation: no Packaged: 2026-07-03 20:13:06 UTC; root Author: Andrea Poletti [aut], Gaia Mazzocchetti [aut, cre], Vincenza Solli [aut] Maintainer: Gaia Mazzocchetti